2,032 results match your criteria Anticancer Agents Med Chem[Journal]


Exploring the Role of Phytochemicals as Potent Natural Photosensitizers in Photodynamic Therapy.

Anticancer Agents Med Chem 2020 Jul 3. Epub 2020 Jul 3.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein. South Africa.

Background: Cancer is still viewed as a deadly disease worldwide due to difficulties in diagnosis, painful treatment procedures, costly therapies, side effects and cancer relapse. Cancer treatments using conventional methods like chemotherapy and radiotherapy were not convincing due to its post-treatment toxicity in the host. In Photodynamic Therapy (PDT) three individual non-toxic components including a photosensitizer, light source and oxygen causes damage to the cells and tissues when they are combined. Read More

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http://dx.doi.org/10.2174/1871520620666200703192127DOI Listing

Therapeutic Monoclonal Antibodies in Clinical Practice against Cancer.

Anticancer Agents Med Chem 2020 Jul 3. Epub 2020 Jul 3.

Chitkara College of Pharmacy, Chitkara University, Punjab. India.

The importance of monoclonal antibodies in oncology has increased drastically following the discovery of Milstein and Kohler. Since the first approval of the monoclonal antibody i.e. Read More

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http://dx.doi.org/10.2174/1871520620666200703191653DOI Listing

Serum Carboxypeptidase N 1 Serves as a Potential Biomarker Complementing CA15-3 for Breast Cancer.

Anticancer Agents Med Chem 2020 Jul 3. Epub 2020 Jul 3.

Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Key laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin. China.

Background: The incidence and mortality of breast cancer are increasing annually. Breast cancer seriously threatens women's health and quality of life. We aimed to measure the clinical value of CPN1, a new serum marker of breast cancer and to evaluate the efficacy of CPN1 in combination with CA15-3. Read More

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http://dx.doi.org/10.2174/1871520620666200703191135DOI Listing

Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells.

Anticancer Agents Med Chem 2020 Jun 27. Epub 2020 Jun 27.

School of Life Sciences, Southwest University, Chongqing, 400715. China.

Background: Gastric cancer, a common malignant tumour worldwide, has a relatively poor prognosis and is a serious threat to human health. Histone Deacetylase inhibitors (HDACi) are anticancer agents that are known to affect the cell growth of different cancer types. Trichostatin A (TSA) selectively inhibits the class I and II mammalian Histone Deacetylase (HDAC) family enzymes and regulates many cell processes, but the underlying mechanisms of HDACs are not fully understood in gastric cancer. Read More

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http://dx.doi.org/10.2174/1871520620666200627204857DOI Listing

Evaluation of Cytotoxic and Tyrosinase Inhibitory Activities of 2-phenoxy(thiomethyl)pyridotriazolopyrimidines: In Vitro and Molecular Docking Studies.

Anticancer Agents Med Chem 2020 Jun 27. Epub 2020 Jun 27.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451. Saudi Arabia.

Background: Aiming of tyrosinase has confirmed to be the best means of recognizing safe, effective, and potent tyrosinase inhibitors for whitening skin. Twenty-four 2-phenoxy(thiomethyl)pyridotriazolopyrimidines were synthesized and characterized in our previous studies.

Objective: The present work aimed to evaluate their cytotoxicity against HepG2 (hepatocellular carcinoma), A549 (pulmonary adenocarcinoma), MCF-7 (breast adenocarcinoma) and WRL 68 (embryonic liver) cell lines. Read More

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http://dx.doi.org/10.2174/1871520620666200627212128DOI Listing

Bestowal of Quinazoline Scaffold in Anticancer Drug Discovery.

Anticancer Agents Med Chem 2020 Jun 27. Epub 2020 Jun 27.

MM College of Pharmacy, MM (Deemed to be University), Mullana, Ambala, HR, 133207. India.

Background: Cancer is one of the major causes of worldwide human mortality. A number of existing antineoplastic medications and treatment regimens are already working in the field and several new compounds are in different phases of clinical trials. An extensive series of anticancer drugs exists in the market, and studies suggest that these molecules are associated with different types of adverse side effects. Read More

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http://dx.doi.org/10.2174/1871520620666200627205321DOI Listing

Aromatase Inhibitors for the Treatment of Breast Cancer: A Journey from the Scratch.

Anticancer Agents Med Chem 2020 Jun 27. Epub 2020 Jun 27.

School of Pharmaceutical Sciences, Guru Ghasdidas Central University, Bilaspur-495 009 (C.G.). India.

Background: Estrogens are essential for the growth of breast cancer in case of premenopausal as well as in postmenopausal women. However, most of the breast cancer incidences are reported in postmenopausal women and the concurrent risk surges with increase in age. Since the enzyme aromatase, catalyses essential steps in estrogen biosynthesis, Aromatase Inhibitors (AIs) are effective targeted therapy in patients with Estrogen Receptor positive (ER+ ) breast cancer. Read More

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http://dx.doi.org/10.2174/1871520620666200627204105DOI Listing

Oxidovanadium(IV) Complex Disrupts Mitochondrial Membrane Potential and Induces Apoptosis in Pancreatic Cancer Cells.

Anticancer Agents Med Chem 2020 Jun 24. Epub 2020 Jun 24.

Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Gdansk. Poland.

Background: At the present time, there is a growing interest in metal-based anticancer agents. Metal complexes exhibit many valuable clinical properties, however, due to toxicity only a few clinically useful complexes have been discovered. It have been demonstrated that synthetic vanadium complexes exhibit many biological activities including anti-cancer properties, however, cellular and molecular mechanisms still are not fully understood. Read More

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http://dx.doi.org/10.2174/1871520620666200624145217DOI Listing

Encapsulation of Imatinib in Targeted KIT-5 Nanoparticles for Reducing its Cardiotoxicity and Hepatotoxicity.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan. Iran.

Background: Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objectives of this study are to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the drug.

Methods: KIT-5 nanoparticles were functionalized with 3-aminopropyltriethoxysilane and conjugated to rituximab as the targeting agent for the CD20 positive receptors of the B-cells. Read More

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http://dx.doi.org/10.2174/1871520620666200619174323DOI Listing

Herbal Based Polymeric Nanoparticles as a Therapeutic Remedy for Breast Cancer.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi-110062. India.

Background: The currently available anti breast cancer agents as well as conventional drug delivery methods have some limitations.

Objective: In view of these limitations, researchers used phytochemicals/herbal extracts as anti-breast cancer agents together with the polymeric nanoparticles to provide an effective way of targeted drug delivery with lesser /no side effects.

Methods: The literature for this review was searched during the year 2014 to 2018 by using the keywords, ' 'breast cancer', 'breast cancer and its current treatments', 'plants against the breast cancer', 'polymeric nanoparticles', 'herbal based polymeric nanoparticles'. Read More

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http://dx.doi.org/10.2174/1871520620666200619171616DOI Listing
June 2020
2.469 Impact Factor

Antigene and Antiproliferative Effects of Triplex-Forming Oligonucleotide (TFO) Targeted on hmgb1 Gene in Human Hepatoma Cells.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi. India.

Background: The high mobility group box 1 (hmgb1) is one of the frequently over-expressed genes whose aberrant expression is reported in a number of human cancers. Various strategies are underway to inhibit hmgb1 expression in cancer cells having considerable therapeutic value.

Objective: The present work involves selective transcriptional inhibition of the hmgb1 gene using selective DNA triplex structure- based gene technology. Read More

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http://dx.doi.org/10.2174/1871520620666200619170438DOI Listing

Biogenic Silver and Zero-Valent Iron Nanoparticles by Feijoa: Biosynthesis, Characterization, Cytotoxic, Antibacterial and Antioxidant Activities.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari. Iran.

Background: and Purpose: Green nanotechnology is an interesting method for the synthesis of functional nanoparticles. Because of their wide application, they have set up great attention in recent years.

Objective: The present research examines the green synthesis of Ag and zero-valent iron nanoparticles (AgNPs, ZVINPs) by Feijoa sellowiana fruit extract. Read More

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http://dx.doi.org/10.2174/1871520620666200619165910DOI Listing
June 2020
2.469 Impact Factor

Anticancer Perspectives of the Fungal-Derived Polyphenolic Hispolon.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Department of Chemistry, The University of Jordan, Amman 11942. Jordan.

Background: Cancer is a dreadful disease causing thousands of deaths per year worldwide, which requires precision diagnostics and therapy. Although the selection of therapeutic regimens depends on the cancer type, chemotherapy remains sustainable treatment strategy despite some of its known side-effects. To date, a number of natural products and their derivatives or analogues have been investigated as potent anticancer drugs. Read More

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http://dx.doi.org/10.2174/1871520620666200619164947DOI Listing
June 2020
2.469 Impact Factor

Smart Nanocarriers for Targeted Cancer Therapy.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa. Italy.

Cancer is considered one of the most threatening diseases worldwide. Although many therapeutic approaches have been developed and optimized for ameliorating patient's conditions and life expectancy, however it frequently remains an incurable pathology. Notably, conventional treatments may reveal inefficient in presence of metastasis development, multidrug resistance and inability to achieve targeted drug delivery. Read More

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http://dx.doi.org/10.2174/1871520620666200619181425DOI Listing

Updates on Receptors Targeted by Heterocyclic Scaffolds: New Horizon in Anticancer Drug Development.

Authors:
Rajeev Kharb

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Centre for Pharmaceutical Chemistry & Pharmaceutical Analysis, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida-201313, Uttar Pradesh. India.

Anticancer is the high priority research area for the scientists as cancer is one the leading causes of deaths globally. It is pertinent to mention here that the conventional anticancer drugs such as methotrexate, vincristine, cyclophosphamide, etoposide, doxorubicin, cisplatin etc. are not much efficient for treatment of different types of cancer; also suffer from serious side effects leading to therapy failure. Read More

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http://dx.doi.org/10.2174/1871520620666200619181102DOI Listing

New Insight into Triple-Negative Breast Cancer Therapy: The Potential Roles of Endoplasmic Reticulum Stress and Autophagy Mechanisms.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: Breast cancer is accounted as the fifth leading cause of mortality among the other cancers. Notwithstanding, Triple Negative Breast Cancer (TNBC) is responsible for the 15-20% of breast cancer mortality. Despite the many investigations, it remains incurable in part due to insufficient understanding of its exact mechanisms. Read More

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http://dx.doi.org/10.2174/1871520620666200619180716DOI Listing

Quinoline-3-carboxylate Derivatives: A New Hope as an Antiproliferative Agent.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Department of Pharmacy, HIMT, Gautam Budh Nagar, Greater Noida, Uttar Pradesh, 201308. India.

Background: The quinoline scaffold has been an attraction due to its pharmacological activities such as antiHIV, anti-neoplastic, anti-asthmatic, anti-tuberculotic, anti-fungal, and anti-bacterial.

Objective: The designed quinoline-3-carboxylate derivatives were synthesized through a two-step reaction and evaluated for antiproliferative activity against MCF-7 and K562 cell lines.

Methods: Synthesized compounds were characterized by modern analytical techniques like NMR, 2DNMR, mass, and IR. Read More

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http://dx.doi.org/10.2174/1871520620666200619175906DOI Listing

Evaluation of a New 99mTc-labeled GnRH Analogue as a Possible Imaging Agent for Prostate Cancer Detection.

Anticancer Agents Med Chem 2020 Jun 19. Epub 2020 Jun 19.

Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran. Iran.

Introduction: Prostate cancer is a serious threat to men's health so it is necessary to develop technics for early detection of this malignancy. The purpose of this research was the evaluation of a new 99mTc-labeled GnRH analogue as an imaging probe for tumor targeting of prostate cancer.

Methods: 99mTc-labeled-DLys6 -GnRH analogue was prepared based on HYNIC as a chelating agent and tricine/ EDDA as coligands for labeling with 99mTc. Read More

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http://dx.doi.org/10.2174/1871520620666200619175352DOI Listing

Paris Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a Mitochondrial Membrane Signaling Pathway.

Anticancer Agents Med Chem 2020 Jun 15. Epub 2020 Jun 15.

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou Province-550014. China.

Background And Purpose: Leukemia considered a top-listed ailment, according to WHO, which contributes to the death of a major population of the world every year. Paris Saponin VII (PS), a saponin which was isolated from the roots of Trillium kamtschaticum, from our group, was reported to provide hemostatic, cytotoxic and antimicrobial activities. However, its molecular mechanism underlying the anti-proliferative effects remains unclear. Read More

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http://dx.doi.org/10.2174/1871520620666200615134039DOI Listing

MicroRNAs as Therapeutic Targets for Anticancer Drugs in Lung Cancer Therapy.

Anticancer Agents Med Chem 2020 Jun 15. Epub 2020 Jun 15.

Key Laboratory of Tumor Molecular Biology in Binzhou Medical University. Department of Biochemistry and Molecular Biology, Binzhou Medical University, YanTai, ShanDong, 264003. China.

MicroRNAs (miRNAs) are short, non-coding RNA molecules that regulate gene expression by translational repression or deregulating of messenger RNAs. Accumulating evidence suggests miRNAs play various roles in the development and progression of lung cancers. Although their precise roles in targeted cancer therapy are currently unclear, miRNAs have been shown to affect the sensitivity of tumors to anticancer drugs. Read More

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http://dx.doi.org/10.2174/1871520620666200615133011DOI Listing

Elevated O-GlcNAcylation Promotes Malignant Phenotypes of Hypopharyngeal Squamous Cell Carcinoma by Stabilizing Nrf2 through Regulation of the PI3K/Akt Pathway.

Anticancer Agents Med Chem 2020 Jun 15. Epub 2020 Jun 15.

Department of Head and Neck Surgery, Nantong Tumor Hospital, Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu. China.

Background And Purpose: O-GlcNAcylation is a significant protein posttranslational modification with O-linked β-N-acetylglucosamine (GlcNAc) for intracellular signaling. Elevated O-GlcNAcylation contributes to cell proliferation, cell migration, cell apoptosis and signal transduction in various cancers. However, the expression level and functional role of O-GlcNAcylation in Hypopharyngeal Squamous Cell Carcinoma (HSCC) is not clearly elucidated. Read More

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http://dx.doi.org/10.2174/1871520620666200615132435DOI Listing

Promising Chemoprevention of Colonic Aberrant Crypt Foci by Portunus segnis Muscle and Shell Extracts in Azoxymethane-Induced Colorectal Cancer in Rats.

Anticancer Agents Med Chem 2020 Jun 12. Epub 2020 Jun 12.

National Cell Bank Department, Pasteur Institute of Iran, Tehran. Iran.

Background And Purpose: This study subjected a rat model to the extracts of muscle and shell tissues from Protonus segnis to assess their therapeutic effects on the HT-29 colon cancer cells as well as on colonic Aberrant Crypt Foci (ACF) induced by Azoxymethane (AOM).

Methods: The cell line was exposed to the extracts to compare cytotoxicity of hexane, butanol, ethyl acetate, and water extract of muscle and ethanolic extract of shell. Male rats (n=40) were assigned into control, positive, negative, and treatment groups. Read More

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http://dx.doi.org/10.2174/1871520620666200612144912DOI Listing

The Radio-Sensitizing Effect of Pharmacological Concentration of Ascorbic Acid on Human Pancreatic Cancer Cells.

Anticancer Agents Med Chem 2020 Jun 12. Epub 2020 Jun 12.

Department of Medical Laboratory Sciences, Para-Medical Faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz. Iran.

Background: Previous studies reported the inevitable destructive effects of radiotherapy on normal adjacent cells. Ascorbic Acid (AA) has been proposed as an effective anti-cancer agent with no obvious effect on normal cells.

Objective: We studied the effects of Ascorbic acid in combination with radiotherapy on human pancreatic carcinoma cell line. Read More

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http://dx.doi.org/10.2174/1871520620666200612144124DOI Listing

Prunus Armeniaca L. Seed Extract and Its Amygdalin Containing Fraction Induced Mitochondrial-Mediated Apoptosis and Autophagy in Liver Carcinogenesis.

Anticancer Agents Med Chem 2020 Jun 8. Epub 2020 Jun 8.

Biochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura. Egypt.

Background: Despite significant advances in therapeutic interventions, liver cancer is the leading cause of cancer mortality in the world. Potential phytochemicals have shown to be promising agents against many life-threatening diseases because of their low toxicity and potential effectiveness.

Objective: The current study aims to an in vitro investigation of the anticancer activity of Apricot Extract (AE) and Amygdalin Containing Fraction (ACF), additionally studying their therapeutic effects in DMBA-induced liver carcinogenesis mice model to highlight their related biochemical and molecular mechanisms. Read More

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http://dx.doi.org/10.2174/1871520620666200608124003DOI Listing

Design, Synthesis and Biological Evaluation of Novel 1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1 (IDO1) Inhibitors.

Anticancer Agents Med Chem 2020 Jun 4. Epub 2020 Jun 4.

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203. China.

Background And Objective: Indoleamine-2,3-dioxygenase 1 (IDO1) which catalyzes degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadostat developed by Incyte Corp is the most advanced IDO1 inhibitor in clinical trials.

Methods: In this study, various amidine derivatives were individually installed as the polar capping group onto the amino ethylene side chain to replace the sulfamoylamino moiety of Epacadostat to develop novel IDO1 inhibitors. Read More

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http://dx.doi.org/10.2174/1871520620666200604121225DOI Listing

Radioactive Gold Nanoparticle in Two Forms ((_79^198)Au GNPs and 99mTc-GNPs) for Lung Cancer Antiproliferative Induction and Intralesional Imaging: A Proof of Concept.

Anticancer Agents Med Chem 2020 May 29. Epub 2020 May 29.

Department of Medical Ultrasonic, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630. China.

Background: Lung cancer is among the most common cancers worldwide, responsible for 13% of all new cancer cases. Also, is the leading cause of cancer death among both men and women. In this scenario, an effective and efficient treatment is required. Read More

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http://dx.doi.org/10.2174/1871520620666200529113818DOI Listing

New Spirocyclic Hydroxamic Acids as Effective Antiproliferative Agents.

Anticancer Agents Med Chem 2020 May 27. Epub 2020 May 27.

Institute of Physiologically Active Compounds of Russian Academy of Sciences, Severny pr. 1, Chernogolovka, Moscow Region, 142432. Russian Federation.

Aims: The main goal of this work where is to synthesize new original spirocyclic hydroxamic acids, investigate their cytotoxicity against to the panel of tumor cell lines and possible mechanism of action of these active compounds.

Background: Hydroxamic acids are one of the promising classes of chemical compounds with proven has anticancer potential properties. This is manifested in the presence of metal chelating and antioxidant activities, the ability to inhibit histone deacetylase enzymes and a chemosensitizing effect against well known cytostatics. Read More

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http://dx.doi.org/10.2174/1871520620666200527132420DOI Listing

Synthesis and Anti-Proliferative Evaluations of New Heterocyclic Derivatives using 5,6,8,9-tetrahydropyrazolo[5,1-b]quinazolin-7(3H)-one Derivatives Derived from Cyclohexa-1,4-dione.

Anticancer Agents Med Chem 2020 May 23. Epub 2020 May 23.

Department of Chemistry, Faculty of Science, Cairo University, Giza. Egypt.

Background: Recentlty pyrazoloquinazoline derivatives acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Through the market it was found that many pharmacological drugs containing the quinazoline nucleus were known.

Objective: We are aiming in this work to synthesize target molecules not only possess anti-tumor activities but also kinase inhibitors. Read More

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http://dx.doi.org/10.2174/1871520620666200523162549DOI Listing

A Systematic Review and Meta-Analysis about the Effect of Bisphosphonates on the Risk of Skeletal-Related Event in Men with Prostate Cancer.

Anticancer Agents Med Chem 2020 May 21. Epub 2020 May 21.

Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province. China.

Background: Although the adjuvant therapy of bisphosphonates in prostate cancer is effective in improving bone mineral density, it's still uncertain whether bisphosphonates could decrease the risk of Skeletal-Related Event (SRE) in patients with prostate cancer. We reviewed and analyzed the effect of different types of bisphosphonates on the risk of SRE, defifined as pathological fracture, spinal cord compression, radiation therapy to bone, surgery to bone, hypercalcemia, bone pain, or death as a result of prostate cancer.

Methods: A systemic literature search was conducted in PubMed and related bibliographies. Read More

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http://dx.doi.org/10.2174/1871520620666200521114815DOI Listing

Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.

Anticancer Agents Med Chem 2020 May 21. Epub 2020 May 21.

División de Inmunología, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco. Mexico.

Background: Dysregulations of the WNT pathway are implicated in the malignant transformation of different types of neoplasia's. WNT7A is expressed in normal peripheral lymphocytes but in the tumoral counterpart is decreased. Furthermore, treatment of leukemic cells with recombinant WNT7A decreases proliferation suggesting its possible use as a therapeutic biomolecule. Read More

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http://dx.doi.org/10.2174/1871520620666200521114100DOI Listing

RecQ Family Helicases in Replication Fork Remodeling and Repair: Opening New Avenues Towards Identification of Potential Targets for Cancer Chemotherapy.

Anticancer Agents Med Chem 2020 May 17. Epub 2020 May 17.

Departmentof Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal. India.

Replication fork reversal and restart has gained immense interest as a central response mechanism to replication stress following DNA damage. Although the exact mechanism of fork reversal has not been elucidated precisely, involvement of diverse pathways and different factors has been demonstrated that are central to this phenomenon. RecQ helicases known for their vital role in DNA repair and maintaining genome stability has recently been implicated in restart of regressed replication forks. Read More

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http://dx.doi.org/10.2174/1871520620666200518082433DOI Listing

Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid.

Anticancer Agents Med Chem 2020 May 16. Epub 2020 May 16.

Department of Organic Chemistry, Gdansk University of Technology, G. Narutowicza 11/12, 80-233 Gdansk. Poland.

Background: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as immunosuppressant, it possesses also anticancer activity. MPA acts as Inosine-5'-Monophosphate Dehydrogenase (IMPDH) inhibitor, where carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. Read More

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http://dx.doi.org/10.2174/1871520620666200516151456DOI Listing

The Potential of Flavonoids and Tannins from Medicinal Plants as Anticancer Agents.

Anticancer Agents Med Chem 2020 May 16. Epub 2020 May 16.

Faculty of Applied Chemistry and Materials Science, University Politehnica Bucharest. Romania.

The tendency of using herbs extracts or natural compounds extracted from herbs for preventing or treating different illness, including cancer, continues to be an alternative to drug use. Many studies of plants compounds are aimed to find substances with selective cytotoxicity on abnormal cells. Phenolic compounds, as important secondary metabolites from plants are between them. Read More

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http://dx.doi.org/10.2174/1871520620666200516150829DOI Listing

Recent Progress in the Development of Quinoline Derivatives for the Exploitation of Anti-cancer Agents.

Anticancer Agents Med Chem 2020 May 16. Epub 2020 May 16.

Institute of Chemistry and BioMedical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023. China.

Background: Along with the progress in medicine and therapies, the exploitation of anti-cancer agents focused more on the vital signaling pathways and key biological macromolecules. With rational design and advanced synthesis, quinoline derivatives have been utilized frequently in medicinal chemistry, especially in developing anti-cancer drugs or candidates.

Methods: Using DOI searching, articles published before 2020 all over the world have been reviewed as comprehensively as possible. Read More

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http://dx.doi.org/10.2174/1871520620666200516150345DOI Listing

MiR-372-3p Predicts Response of TACE Patients Treated with Doxorubicin and Enhances Chemosensitivity in Hepatocellular Carcinoma.

Anticancer Agents Med Chem 2020 May 16. Epub 2020 May 16.

Department of Cancer Biology, National Cancer Institute, Cairo University, Giza. Egypt.

Background: Identification of factors to detect and improve chemotherapy-response in cancer is a main concern. microRNA-372-3p (miR-372-3p) has been demonstrated to play a crucial role in cellular proliferation, apoptosis and metastasis of various cancers including Hepatocellular Carcinoma (HCC). However, its contribution towards Doxorubicin (Dox) chemosensitivity in HCC has never been studied. Read More

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http://dx.doi.org/10.2174/1871520620666200516145830DOI Listing

Molecular Docking, Antioxidant, Anticancer and Antileishmanial Effects of Newly Synthesized Quinoline Derivatives.

Anticancer Agents Med Chem 2020 May 16. Epub 2020 May 16.

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad. Pakistan.

Background: Due to the need and adverse effects associated with the available anticancer agents, an attempt was made to develop the new anticancer agents with better activity and lesser adverse effects.

Objective: Synthetic approaches based on chemical modification of quinoline derivatives have been undertaken with the aim of improving anticancer agents' safety profile.

Methods: In presentstudy quinoline derivatives 6-hydroxy-2-(4-methoxyphenyl) quinoline-4-carboxylic acid (M1) and 2-(4- chlorophenyl)-6-hydroxyquinoline-4-carboxylic acid (M3) were synthesized by reaction of aldehyde and pyruvic acid. Read More

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http://dx.doi.org/10.2174/1871520620666200516145117DOI Listing

Benzophenone Sulfonamide Derivatives as Interacting Partners and Inhibitors of Human P-glycoprotein.

Anticancer Agents Med Chem 2020 May 16. Epub 2020 May 16.

Department of Biochemistry, Abdul Wali Khan, University Mardan, Khyber Pakhtunkhwa. Pakistan.

Background: Human P-glycoprotein (P-gp) is a transmembrane protein that belongs to the ATP-Binding Cassette (ABC) transporters family. Physiologically, it exports toxins out of the cell, however, its over-expression leads to the phenomena of MultidrugResistance (MDR) by exporting a diverse range of compounds, which are structurally and chemically different from each other, thus creating a hurdle in the treatment of various diseases including cancer. The current study was designed to screen benzophenone sulfonamide derivatives as a class of inhibitors and potential anticancer agents for P-gp. Read More

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http://dx.doi.org/10.2174/1871520620666200516144403DOI Listing

Assessment of Ploy Dopamine Coated Fe3O4 Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection.

Anticancer Agents Med Chem 2020 May 12. Epub 2020 May 12.

Department of Radiology, Askarieh Hospital, Isfahan. Iran.

Objective: Poly dopamine coated iron oxide nanoparticles (FeO@PDA NPs) were synthesized, characterized, and their MR imaging contrast agents and photothermal potency were evaluated on melanoma (B16-F10 and A-375) cells and normal skin cell. To this end, MTT assay, Fe concentration, and MR imaging of both coated and uncoated NPs were assessed in C57BL/6 mice.

Methods: Fe3O4 nanoparticles were synthesized using co-precipitation, and coated with poly dopamine. Read More

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http://dx.doi.org/10.2174/1871520620666200513084616DOI Listing
May 2020
2.469 Impact Factor

The Anti-Tumor Activity of Afatinib in Pancreatic Ductal Adenocarcinoma Cells.

Anticancer Agents Med Chem 2020 May 7. Epub 2020 May 7.

Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004. China.

Background: Pancreatic Ductal Adenocarcinoma (PDAC) is the most common form of pancreatic cancer and leading causes of pancreatic cancer death because of most PDAC patients with advanced unresectable disease at that time, which is remarkably resistant to all forms of chemotherapy and radiotherapy.

Objective: PDAC increases the social and patients family burden. However, the PDAC pathogenesis is not identified. Read More

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http://dx.doi.org/10.2174/1871520620666200508090515DOI Listing
May 2020
2.469 Impact Factor

Repurposing of Alexidine Dihydrochloride as an Apoptosis-Initiator and Cell Cycle Inhibitor in Human Pancreatic Cancer.

Anticancer Agents Med Chem 2020 May 7. Epub 2020 May 7.

Department of Medical Genetics, Yeditepe University Medical School and Yeditepe University Hospital, Istanbul. Turkey.

Background: Highly aggressive and resistant to chemotherapy, pancreatic cancers are the fourth leading cause of cancer-related deaths in the western world. The absence of effective chemotherapeutics is leading researchers to develop novel drugs or repurpose existing chemicals. Alexidine Dihydrochloride (AD), an orally bioavailable bisbiguanide compound, is an apoptosis stimulating reagent. Read More

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http://dx.doi.org/10.2174/1871520620666200508085439DOI Listing
May 2020
2.469 Impact Factor

Schiff Bases and Complexes: A Review on Anti-Cancer Activity.

Authors:
Garima Matela

Anticancer Agents Med Chem 2020 May 6. Epub 2020 May 6.

Department of Chemistry, Kumaun University, GDC Jainti-263626 Almora, Uttarakhand. India.

Development in the field of bio-inorganic chemistry increased the interest in Schiff base and it's complexes due to its biological importance in many fields, including anticancer activity. Discovery of the antitumor activity of Schiff base and it's complexes against various tumor cell lines, fascinates the researchers to develop new anticancer drugs without any side effects. Thus, the present review is focusing on the anticancer activity of Schiff bases and its metal complexes. Read More

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http://dx.doi.org/10.2174/1871520620666200507091207DOI Listing

Anticancer Properties of Asian Water Monitor Lizard (Varanus salvator), Python (Malayopython reticulatus) and Tortoise (Cuora kamaroma amboinensis).

Anticancer Agents Med Chem 2020 May 3. Epub 2020 May 3.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, University City, Sharjah. United Arab Emirates.

Background: Cancer contributes to significant morbidity and mortality despite advances in treatment and supportive care. There is a need for identification of effective anticancer agents. Reptiles such as tortoise, python, and water monitor lizards are exposed to heavy metals, tolerate high levels of radiation, feed on rotten/germ-infested feed, thrive in unsanitary habitat and yet have prolonged lifespans. Read More

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http://dx.doi.org/10.2174/1871520620666200504103056DOI Listing

Paclitaxel Nanoparticles Induce Apoptosis and Regulate TXR1, CYP3A4 and CYP2C8 in Breast Cancer and Hepatoma Cells.

Anticancer Agents Med Chem 2020 May 3. Epub 2020 May 3.

Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta. Egypt.

Background And Objective: Although the anticancer potentials of water insoluble drugs are improved by nanoformulation, other intervening factors may contribute in the drug efficacy. This work was designated to explore the effect of paclitaxel-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles on the viability of cancer cells, the expression of Taxol resistance gene I (TXR1) and paclitaxel metabolizing genes.

Methods: Paclitaxel loaded PLGA nanoparticles (PTX-NPs) were prepared, physically characterized and used in treatment of breast adenocarcinoma cells (MCF-7) and hepatoma cells (HepG2). Read More

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http://dx.doi.org/10.2174/1871520620666200504071530DOI Listing

The Apoptosis Mechanism of Epirubicin Combined with BCG on Human Bladder Cancer Cells.

Anticancer Agents Med Chem 2020 May 1. Epub 2020 May 1.

School of Bioscience and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006. China.

Aims: The purpose of our study is to explore the combination effect of epirubicin and Bacillus Calmette Guerin (BCG) and its mechanism.

Background: Bladder cancer is a threat to human health worldwide. Commonly used chemotherapy drugs and biotherapy have significant therapeutic effects on bladder cancer, but the mechanism and combined effects are still unclear. Read More

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http://dx.doi.org/10.2174/1871520620666200502004002DOI Listing

Preparation and Preliminary Evaluation of 68Ga-Acridine: An Attempt to Study the Potential of Radiolabeled DNA Intercalator as a PET Radiotracer for Tumor Imaging.

Anticancer Agents Med Chem 2020 May 1. Epub 2020 May 1.

Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai - 400085. India.

Introduction: Acridine is a well-known DNA intercalator and thereby gets easily inserted within DNA. As uncontrolled rapid cell division is one of the primary characteristics of the tumors, it is expected that acridine or its suitable derivatives will have preferential accumulation in the tumorous lesions. Therefore, an attempt was made to radiolabel an acridine derivative with 68Ga and study the potential of the 68Ga-acridine complex as a PET agent for tumor imaging. Read More

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http://dx.doi.org/10.2174/1871520620666200502002609DOI Listing
May 2020
2.469 Impact Factor

Synthesis of Some Benzimidazole-derived Molecules and Their Effects on PARP-1 Activity and MDA-MB-231, MDA-MB-436, MDA-MB-468 Breast Cancer Cell Viability.

Anticancer Agents Med Chem 2020 May 1. Epub 2020 May 1.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06560 Tandogan, Ankara. Turkey.

Background: Poly (ADP-ribosyl) polymerase-1 (PARP-1) inhibitors are compounds that are used to treat cancers, which are defective in DNA-repair and DNA Damage-Response (DDR) pathways.

Objective: In this study, a series of potential PARP-1 inhibitor substituted (piperazine-1-carbonyl)phenyl)-1H- benzo[d]imidazole4-carboxamide compounds were synthesised and tested for their PARP-1 inhibitory and anti-cancer activities.

Methods: Compounds were tested by cell free colorimetric PARP-1 activity and MTT assay in MDA-MB-231, MDA-MB-436, MDA-MB-468 breast cancer and L929 fibroblast cell lines. Read More

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http://dx.doi.org/10.2174/1871520620666200502001953DOI Listing

MiR-520c-3p Modulates Doxorubicin-chemosensitivity in HepG2 cells.

Anticancer Agents Med Chem 2020 May 1. Epub 2020 May 1.

Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo. Egypt.

Background: Doxorubicin (DOX) is the most common drugs used in cancer therapy, including Hepatocellular Carcinoma (HCC). Drug resistance, is one of chemotherapy's significant problems. Emerging studies have shown that microRNAs (miRNAs) could participate in regulating this mechanism. Read More

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http://dx.doi.org/10.2174/1871520620666200502004817DOI Listing

Zidovudine Glycosylation by Filamentous Fungi Leads to Better Redox Stability and Improved Cytotoxicity on B16F10 Murine Melanoma Cells.

Anticancer Agents Med Chem 2020 Apr 24. Epub 2020 Apr 24.

Laboratório de Bioconversão, Faculdade de Farmácia, Universidade Federal de Goiás, P.O. Box 131, Goiânia, GO. Brazil.

Background: The strategic development of therapeutic agents capable of being targeted at their active sites has been a major goal in the treatment of cancer. The delivery of drugs for tumors has as its main challenge the development of safe and effective drugs, since the goal of chemotherapy is to eliminate the tumor completely without reaching healthy cells. The aim of the present study was to investigate the antioxidant, anticancer activitie of zidovudine and its α-O-glycosylated derivative obtained by biosynthesis using the filamentous fungi Cunninghamela echinulata. Read More

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http://dx.doi.org/10.2174/1871520620666200424112504DOI Listing

Isolation, Characterization and Preliminary Cytotoxic and Antifungal Evaluations of Novel Lancifoliate Isolated from Methanol Extract of Conocarpus lancifolius.

Anticancer Agents Med Chem 2020 Apr 24. Epub 2020 Apr 24.

Faculty of Pharmacy, Bahaudin Zakariya University, Multan. Pakistan.

Background: Combretaceae is a large family comprising of 500 species and 20 genera distributed in subtropical and tropical regions of world. Conocarpus genus is an ornamental tree native to coastal and riverine areas of East Africa and is planted as an ornamental plant in different areas of Pakistan. This genus has proved medicinal value as a cytotoxic, antibacterial, antiprotozoal, anti-leishmanial, antifungal and antidiabetic agent. Read More

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http://dx.doi.org/10.2174/1871520620666200424110923DOI Listing
April 2020
2.469 Impact Factor

Synthesis, In Vitro Anticancer, Anti-Inflammatory and DNA Binding Activity of Thiazolidinedione Derivatives.

Anticancer Agents Med Chem 2020 Apr 23. Epub 2020 Apr 23.

Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka. India.

Background: Cancer is the second leading cause of mortality worldwide. Despite of several advances made in the treatment strategies, cure for cancer remains still a challenge. Currently used treatment modalities pose several side effects and remain ineffective in the later stages. Read More

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http://dx.doi.org/10.2174/1871520620666200424102615DOI Listing