842,038 results match your criteria Antibiotics Basel Switzerland[Journal]


The impact of antibiotic allergy testing in transplant patients.

Transpl Infect Dis 2020 Jul 11:e13411. Epub 2020 Jul 11.

Department of Infectious Diseases and Centre for Antibiotic Allergy and Research, Austin Health,, VIC, Australia.

Patient reported antibiotic allergies, so-called antibiotic allergy labels (AAL) are highly prevalent amongst hospitalized patients globally . The highest prevalence of AALs has been found to be in immunocompromised patients, in particular transplant patients, with a large U.S. Read More

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http://dx.doi.org/10.1111/tid.13411DOI Listing

Synthesis of antiviral perfluoroalkyl derivatives of teicoplanin and vancomycin.

ChemMedChem 2020 Jul 11. Epub 2020 Jul 11.

Debreceni Egyetem, Pharmaceutical Chemistry, HUNGARY.

The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Here, we describe a new strategy for the synthesis of dual hydrophobic and lipophobic derivatives of glycopeptides, to produce selective antiviral agents without membrane-disrupting activity. Read More

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http://dx.doi.org/10.1002/cmdc.202000260DOI Listing

Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.

FASEB J 2020 Jul 11. Epub 2020 Jul 11.

Institute of Pharmacy, Center for Public Health, Paracelsus Medical University, Salzburg, Austria.

Sorafenib represents the current standard of care for patients with advanced-stage hepatocellular carcinoma (HCC). However, acquired drug resistance occurs frequently during therapy and is accompanied by rapid tumor regrowth after sorafenib therapy termination. To identify the mechanism of this therapy-limiting growth resumption, we established robust sorafenib resistance HCC cell models that exhibited mitochondrial dysfunction and chemotherapeutic crossresistance. Read More

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http://dx.doi.org/10.1096/fj.202001128RDOI Listing

Pasteurella Multiocida infection resulting in a descending thoracic aorta mycotic pseudoaneurysm.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Division of Vascular Surgery, College of Medicine, University of Florida, Gainesville, Florida.

Objective: Highlight our management of a Pasteurella Multiocida-infected descending thoracic aorta mycotic pseudoaneurysm.

Methods: Report a case of a canine bite resulting in a P. Multiocida descending thoracic aorta mycotic pseudoaneurysm. Read More

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http://dx.doi.org/10.1111/jocs.14776DOI Listing

Absorbable antibiotic beads as an adjuvant therapy in treating ventricular assist devices driveline infection: A case report.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiothoracic Surgery, Mayo Clinic, Jacksonville, Florida.

Background: Ventricular assist devices driveline infections are common, recalcitrant, and carry high morbidity and mortality. Herein, we reported a patient with driveline infection that was successfully treated with a combination of systemic antibiotics, surgical debridement, and instillation of absorbable antibiotic beads to the wound bed.

Methods And Results: A 39-year-old man with nonischemic cardiomyopathy underwent insertion of a continuous flow left ventricular assist device. Read More

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http://dx.doi.org/10.1111/jocs.14778DOI Listing

Molecular mechanisms of enterococcal-bacteriophage interactions and implications for human health.

Curr Opin Microbiol 2020 Jul 8;56:38-44. Epub 2020 Jul 8.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, United States. Electronic address:

Once overlooked as passive bystanders of the human intestinal microbiota, new evidence is shedding light on the importance of enterococci and their bacteriophages (phages) in shaping human health. Natural predators of enterococci, phages represent a narrow spectrum, precision targeting modality for the eradication of problematic enterococci within the microbiota or infected tissue. The identification of enterococcal phage receptors, absorption factors, and transcriptional responses following phage infection reveals a complex predator-prey relationship that modulates enterococcal cell surface architecture, susceptibility to antibiotics, and adaptation to host associated environments. Read More

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http://dx.doi.org/10.1016/j.mib.2020.06.003DOI Listing

Biochar affects the dissipation of antibiotics and abundance of antibiotic resistance genes in pig manure.

Bioresour Technol 2020 Jul 6;315:123782. Epub 2020 Jul 6.

Soil Science, University of Trier, Trier, Germany. Electronic address:

Manure from medicated livestock contains pharmaceutical antibiotics and antibiotic resistance genes (ARGs). Bioavailable antibiotics trigger further ARGs amplification during manure storage. It was tested whether biochar lowers the bioavailability of the antibiotics sulfamethazine (SMZ), ciprofloxacin (CIP), oxytetracycline (OTC) and florfenicol (FF) in manure and the amplification of sul1 and tet(W) ARGs. Read More

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http://dx.doi.org/10.1016/j.biortech.2020.123782DOI Listing

Mesenteric venous thrombosis complicating acute appendicitis: A case series.

Int J Surg Case Rep 2020 Jun 27;73:100-104. Epub 2020 Jun 27.

Department of Neurosurgery, Mayo Clinic Health System, Eau Claire, WI, USA. Electronic address:

Introduction: Acute appendicitis is one of the most common surgical conditions. In the current era it rarely presents in association with mesenteric venous thrombosis. We present 4 cases of mesenteric venous thrombosis occurring in the setting of acute appendicitis. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.099DOI Listing

Scope and limitations on aerosol drug delivery for the treatment of infectious respiratory diseases.

J Control Release 2020 Jul 8. Epub 2020 Jul 8.

Aix Marseille Univ, INSERM, SSA, MCT, 13385 Marseille, France. Electronic address:

The rise of antimicrobial resistance has created an urgent need for the development of new methods for antibiotics delivery to patients with pulmonary infections in order to mainly increase the effectiveness of the drugs administration, to minimize the risk of emergence of resistant strains, and to prevent patients reinfection. Since bacterial resistance is often related to antibiotic concentration, their pulmonary administration could eradicate strains resistant to the same drug at the concentration achieved through the systemic circulation. Pulmonary administration offers several advantages; it directly targets the site of the infection which allows the inhaled dose of the drug to be reduced compared to that administered orally or parenterally while keeping the same local effect. Read More

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http://dx.doi.org/10.1016/j.jconrel.2020.07.002DOI Listing

Ureidothiophene inhibits interaction of bacterial RNA polymerase with -10 promotor element.

Nucleic Acids Res 2020 Jul 11. Epub 2020 Jul 11.

Centre for Bacterial Cell Biology, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle Upon Tyne NE2 4AX, UK.

Bacterial RNA polymerase is a potent target for antibiotics, which utilize a plethora of different modes of action, some of which are still not fully understood. Ureidothiophene (Urd) was found in a screen of a library of chemical compounds for ability to inhibit bacterial transcription. The mechanism of Urd action is not known. Read More

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http://dx.doi.org/10.1093/nar/gkaa591DOI Listing

Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications.

Eur J Nutr 2020 Jul 10. Epub 2020 Jul 10.

Research Department, Sidra Medicine, Doha, Qatar.

Purpose: Although genetic predisposition and exposure to dietary gluten are considered necessary triggers for the development of coeliac disease, alterations in the gut microbial composition may also contribute towards the pathogenesis of coeliac disease. This review aims to provide an overview of the available data on the potential mechanisms through which the gut microbiota plays a role in the causation of coeliac disease and to discuss the potential therapeutic strategies that could diminish the consequences of microbial dysbiosis.

Method: A search of the literature was performed using the PubMed, Embase, and JSTOR databases; relevant articles were included. Read More

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http://dx.doi.org/10.1007/s00394-020-02324-yDOI Listing

Persistent aseptic meningitis in a child-think patch.

Wien Med Wochenschr 2020 Jul 10. Epub 2020 Jul 10.

Hospital for General Paediatrics and Neonatology, Saarland University Medical Center, Homburg/Saar, Germany.

Background: In patients with neurosurgical interventions requiring dura reconstruction, the use of bovine graft material may be required.

Patients And Methods: Case report.

Results: We present a 12-year-old girl with a profound graft reaction with severe neurologic symptoms mimicking post-neurosurgical bacterial meningitis after resection of an infra-tentorial brain tumour. Read More

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http://dx.doi.org/10.1007/s10354-020-00765-yDOI Listing

Safe use of paracetamol and high-dose NSAID analgesia in dentistry during the COVID-19 pandemic.

Br Dent J 2020 Jul;229(1):15-18

Department of Oral Medicine, NHS Greater Glasgow and Clyde, Glasgow Dental Hospital and School, 378 Sauchiehall Street, Glasgow, UK.

With dental services currently altered, dentists are being asked to provide advice, analgesia and antibiotics in situations where they would normally be offering operative care. Dentists are familiar with using analgesia for short courses for their patients, but using higher-dose regimes and for periods of over two weeks brings special challenges. This paper reviews the areas where special precautions are needed when using analgesia in the current situation. Read More

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http://dx.doi.org/10.1038/s41415-020-1784-3DOI Listing

Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome.

Sci Rep 2020 Jul 10;10(1):11409. Epub 2020 Jul 10.

Chair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer-Institute, Faculty of Medicine, LMU Munich, Munich, Germany.

Helicobacter pylori is a gram-negative, spiral-shaped bacterial pathogen and the causative agent for gastritis, peptic ulcer disease and classified as a WHO class I carcinogen. While the prevalence of H. pylori infections in Africa is among the highest in the world, the incidence of gastric cancer is comparably low. Read More

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http://dx.doi.org/10.1038/s41598-020-66128-0DOI Listing

Genetic testing in the acute setting: a round table discussion.

J Med Ethics 2020 Jul 10. Epub 2020 Jul 10.

Manchester Centre for Genomic, Manchester University NHS Foundation Trust, Manchester, UK

Genetic testing has historically been performed in the context of chronic disease and cancer diagnostics. The timelines for these tests are typically measured in days or weeks, rather than in minutes. As such, the concept that genetic information might be generated and then used to alter management in the acute setting has, thus far, not been feasible. Read More

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http://dx.doi.org/10.1136/medethics-2019-106043DOI Listing

Effect of chitosan microparticles on the uterine microbiome of dairy cows with metritis.

Appl Environ Microbiol 2020 Jul 10. Epub 2020 Jul 10.

Department of Biomedical Veterinary Sciences, College of Veterinary Medicine, Long Island University, Brookville, NY 11548.

The objective was to evaluate the effect of chitosan microparticles on the uterine microbiome of cows with metritis. Dairy cows with metritis (n = 89) were assigned to 1 of 3 treatments: chitosan microparticles (n = 21) = intrauterine infusion of chitosan microparticles at metritis diagnosis (D0), D2 and D4; ceftiofur (n = 25) = subcutaneous injection of ceftiofur on D0 and D3; Untreated (n = 23) = no treatment. Non-metritic (n = 20) = healthy cows matched by days postpartum at metritis diagnosis. Read More

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http://dx.doi.org/10.1128/AEM.01066-20DOI Listing

Oral and topical exposure to glyphosate in herbicide formulation impact the gut microbiota and survival rates of honey bees.

Appl Environ Microbiol 2020 Jul 10. Epub 2020 Jul 10.

Department of Integrative Biology, University of Texas at Austin, Texas, USA

Honey bees are important agricultural pollinators that rely on a specific gut microbiota for regulation of immune system and defense against pathogens. Environmental stressors that affect the bee gut microbial community, such as antibiotics and glyphosate, can indirectly compromise bee health. Most of the experiments demonstrating these effects have been done under laboratory conditions with pure chemicals. Read More

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http://dx.doi.org/10.1128/AEM.01150-20DOI Listing

Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections.

EBioMedicine 2020 Jun 27:102867. Epub 2020 Jun 27.

Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, W591, Columbus, OH 43205 USA; The Ohio State University College of Medicine, 700 Children's Drive, Columbus, OH 43210 USA. Electronic address:

Background: Chronic and recurrent bacterial diseases are recalcitrant to treatment due to the ability of the causative agents to establish biofilms, thus development of means to prevent or resolve these structures are greatly needed. Our approach targets the DNABII family of bacterial DNA-binding proteins, which serve as critical structural components within the extracellular DNA scaffold of biofilms formed by all bacterial species tested to date. DNABII-directed antibodies rapidly disrupt biofilms and release the resident bacteria which promote their subsequent clearance by either host immune effectors or antibiotics that are now effective at a notably reduced concentration. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102867DOI Listing

Meta-analysis in periprosthetic joint infection: a global bibliometric analysis.

J Orthop Surg Res 2020 Jul 10;15(1):251. Epub 2020 Jul 10.

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Musculoskeletal Surgery (CMSC), Charitéplatz 1, D-10117, Berlin, Germany.

Background: Periprosthetic joint infection (PJI) is the most serious complication of joint replacement surgery. Further comorbidities include bedsore, deep vein thrombosis, reinfection, or even death. An increasing number of researchers are focusing on this challenging complication. Read More

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http://dx.doi.org/10.1186/s13018-020-01757-9DOI Listing

Testing the regulatory framework in South Africa - a single-blind randomized pilot trial of commercial probiotic supplementation to standard therapy in women with bacterial vaginosis.

BMC Infect Dis 2020 Jul 10;20(1):491. Epub 2020 Jul 10.

Division of Medical Virology, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa.

Background: Bacterial vaginosis (BV) increases HIV risk and adverse reproductive outcomes. Standard-of-care (SOC) for BV are antibiotics; however, cure rates are low. Probiotics for vaginal health may be useful in improving cure and recurrence although the regulatory framework governing probiotics and the conduct of randomized clinical trials to evaluate these has not been established in South Africa. Read More

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http://dx.doi.org/10.1186/s12879-020-05210-4DOI Listing

The Addition of a Synthetic LPS-Targeting Domain Improves Serum Stability While Maintaining Antimicrobial, Antibiofilm, and Cell Stimulating Properties of an Antimicrobial Peptide.

Biomolecules 2020 Jul 8;10(7). Epub 2020 Jul 8.

Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

Multi-drug resistant (MDR) bacteria and their biofilms are a concern in veterinary and human medicine. Protegrin-1 (PG-1), a potent antimicrobial peptide (AMP) with antimicrobial and immunomodulatory properties, is considered a potential alternative for conventional antibiotics. AMPs are less stable and lose activity in the presence of physiological fluids, such as serum. Read More

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http://dx.doi.org/10.3390/biom10071014DOI Listing

In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors.

Molecules 2020 Jul 8;25(14). Epub 2020 Jul 8.

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.

Two sets of diphenyl ether derivatives incorporating five-membered 1,3,4-oxadiazoles, and their open-chain aryl hydrazone analogs were synthesized in good yields. Most of the synthesized compounds showed promising in vitro antimycobacterial activity against H37Rv. Three diphenyl ether derivatives, namely hydrazide , oxadiazole and naphthylarylidene exhibited pronounced activity with minimum inhibitory concentrations (MICs) of 0. Read More

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http://dx.doi.org/10.3390/molecules25143125DOI Listing

Antimicrobial Spectrum of Titroleane™: A New Potent Anti-Infective Agent.

Antibiotics (Basel) 2020 Jul 8;9(7). Epub 2020 Jul 8.

SETUBIO SA, Bioparc Vichy, F-03270 Hauterive, France.

Tea Tree oil (TTO) is well known for its numerous good properties but might be also irritating or toxic when used topically or ingested, thus limiting the number of possible applications in Humans. The aim of the study was to characterize the antimicrobial spectrum as well as the toxicity of Titroleane™, a new anti-infective agent obtained from TTO but cleared of its toxic monoterpenes part. The susceptibility to Titroleane™ of various pathogens (bacteria and fungi) encountered in animal and human health was studied in comparison with that of TTO. Read More

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http://dx.doi.org/10.3390/antibiotics9070391DOI Listing

Antimicrobial and Efflux Pump Inhibitory Activity of Carvotacetones from Against Mycobacteria.

Antibiotics (Basel) 2020 Jul 8;9(7). Epub 2020 Jul 8.

Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4, 8010 Graz, Austria.

Carvotacetones () isolated from were screened for their antimycobacterial and efflux pump (EP) inhibitory potential against the mycobacterial model strains mc 155, ATCC 23366, and BCG ATCC 35734. The minimum inhibitory concentrations (MICs) of the carvotacetones were detected through high-throughput spot culture growth inhibition (HT-SPOTi) and microbroth dilution assays. In order to assess the potential of the compounds and to accumulate ethidium bromide (EtBr) in and , a microtiter plate-based fluorometric assay was used to determine efflux activity. Read More

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http://dx.doi.org/10.3390/antibiotics9070390DOI Listing

Housing and Management of Turkey Flocks in Canada.

Animals (Basel) 2020 Jul 8;10(7). Epub 2020 Jul 8.

Department of Animal Biosciences, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.

An increased understanding of the turkey sector and how farmers manage flocks can help maintain and improve the health and welfare of turkeys. We conducted a cross-sectional survey among turkey farmers in Canada to gain information regarding general farm characteristics, housing aspects (incl. lighting, ventilation), litter management, feed and water management, flock characteristics, and flock health management. Read More

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http://dx.doi.org/10.3390/ani10071159DOI Listing

Patterns of Antibiotic Prescription in Colombia: Are There Differences between Capital Cities and Municipalities?

Antibiotics (Basel) 2020 Jul 8;9(7). Epub 2020 Jul 8.

Departament de Farmacologia, Terapèutica i Toxicología, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.

The use of antibiotics is the most important modifiable risk factor for the development of microorganism resistance. A cross-sectional study of outpatients receiving antibiotic prescriptions registered in a population database in Colombia was conducted. The characteristics of the consumption in capital cities and small municipalities was studied and the AWaRe classification was used. Read More

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http://dx.doi.org/10.3390/antibiotics9070389DOI Listing

Methicillin-Resistant Diabetic Foot Crossed Infection: A Case Report.

Pathogens 2020 Jul 8;9(7). Epub 2020 Jul 8.

Department of Podiatry, University of Seville, 41009 Seville, Spain.

This work presents a protocol to prevent the transmission of multidrug-resistant infections. We focus on the Diabetic Foot Unit Podiatry Clinic Area attached to the University of Seville in particular. The most common complication for patients with diabetes is leg ulcers. Read More

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http://dx.doi.org/10.3390/pathogens9070549DOI Listing

Isolation and Characterization of Bacteriophages That Infect , a Model Pathogen for Intestinal Diseases.

Viruses 2020 Jul 8;12(7). Epub 2020 Jul 8.

Department of Biology, San Diego State University, San Diego, CA 92182, USA.

Enteropathogenic (EPEC) is a major pathogen for diarrheal diseases among children. Antibiotics, when used appropriately, are effective; however, their overuse and misuse have led to the rise of antibiotic resistance worldwide. Thus, there are renewed efforts into the development of phage therapy as an alternative antibacterial therapy. Read More

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http://dx.doi.org/10.3390/v12070737DOI Listing

Conspiracy Beliefs Are Associated with Lower Knowledge and Higher Anxiety Levels Regarding COVID-19 among Students at the University of Jordan.

Int J Environ Res Public Health 2020 Jul 8;17(14). Epub 2020 Jul 8.

Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, the University of Jordan, Amman 11942, Jordan.

The world has been afflicted heavily by the burden of coronavirus disease 2019 (COVID-19) that overwhelmed health care systems and caused severe economic and educational deficits, in addition to anxiety among the public. The main aim of this study was to evaluate the mutual effects of belief that the pandemic was the result of a conspiracy on knowledge and anxiety levels among students at the University of Jordan (UJ). An electronic-based survey was conducted between 29 March, 2020 and 31 March, 2020. Read More

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http://dx.doi.org/10.3390/ijerph17144915DOI Listing

Strong Shear Flow Persister Bacteria Resist Mechanical Washings on the Surfaces of Various Polymer Materials.

Adv Biosyst 2017 Dec 21;1(12):e1700161. Epub 2017 Nov 21.

Hefei National Laboratory for Physical Sciences at the Microscale, Department of Polymer Science and Engineering, CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. China.

Environmental bacteria persistently exist in hospitals and thereby often contaminate biomedical devices, which usually causes device-associated infections that have become a major cause of patient illness and death in the hospital. In this study, for the first time, the identification of strong shear flow persister (SSP) cells in Pseudomonas aeruginosa is reported. Unlike common persister cells that are highly tolerant to antibiotics, it is reported that the SSP cells can resist mechanical washings on the surfaces of various polymer materials and can form distinctive biofilms that are tolerant to high doses of aminoglycoside antibiotics. Read More

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http://dx.doi.org/10.1002/adbi.201700161DOI Listing
December 2017

Antirheumatic drugs for COVID-19 treatment based on the phases of the disease: Current concept.

J Popul Ther Clin Pharmacol 2020 Jun 27;27(S Pt 1):e14-e25. Epub 2020 Jun 27.

Orthopaedic Unit, San Pier Damiano Hospital, Faenza (RA), Italy;

COVID-19 disease is the most recent pandemic, since it has affected more than four and a half million people and caused more than 300,000 deaths. It is a very complex systemic disease in terms of pathogenesis, treatment, and prognosis. Pharmacological treatment may include antiviral and antimalarial drugs, antibiotics, monoclonal antibodies, corticosteroids as well as low-molecular-weight heparins to prevent the evolution of the disease from reaching the severe inflammatory phase that can lead to respiratory complications, multiple organ failure, disseminated intravascular coagulation (DIC), and finally death. Read More

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http://dx.doi.org/10.15586/jptcp.v27iSP1.689DOI Listing

Enhanced ozonation of ciprofloxacin in the presence of bromide: Kinetics, products, pathways, and toxicity.

Water Res 2020 Jun 28;183:116105. Epub 2020 Jun 28.

Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA.

Although the ozonation of common antibiotics, such as ciprofloxacin (CIP), in water has been well studied, the influence of bromide that is present at high levels in seawater, is essentially unknown. In this study, we investigated the effect of bromide on the reaction kinetics, formation of transformation products (TPs), reaction pathways, and toxicity in the ozonation of CIP. Bromide significantly accelerated the transformation of CIP by ozone, likely due to the formation of reactive bromine species. Read More

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http://dx.doi.org/10.1016/j.watres.2020.116105DOI Listing

Field trial on the post-insemination intrauterine treatment of dairy cows with mild endometritis with cephapirin.

Theriogenology 2020 Jun 29;156:20-26. Epub 2020 Jun 29.

Clinical Unit for Herd Health Management in Ruminants, University Clinic for Ruminants, Department of Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria.

Cows in estrus but with signs of clinical endometritis (CE) are often not inseminated or undergo an intrauterine treatment after artificial insemination (AI). Decades ago, the so-called Aström method was described as intrauterine infusion of iodine-potassium solution 2-4 days after AI. Nowadays, it is common to use antibiotics instead of iodine solution and the treatment is performed only a few hours after AI. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.06.024DOI Listing

Investigation on the adsorption and desorption behaviors of antibiotics by degradable MPs with or without UV ageing process.

J Hazard Mater 2020 Jul 2;401:123363. Epub 2020 Jul 2.

Key Laboratory of Industrial Pollution Control and Resource Reuse of Jiangsu Province, College of Environmental Engineering, Xuzhou University of Technology, Xuzhou, 221018, China.

To assess the potential vector effects of degradable MPs (microplastics) on the coexisting pollutant, the adsorption-desorption behaviors of tetracycline (TC) and ciprofloxacin (CIP) by the original and aged polylactic acid (PLA) was investigated. Compared with PVC, the physicochemical properties of PLA changed more observably during the UV ageing. The original smooth surface of PLA appeared holes and cracks, and the S of PLA increased a 2. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123363DOI Listing

Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin.

Eur J Pharm Sci 2020 Jul 7:105453. Epub 2020 Jul 7.

School of Pharmacy, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. Electronic address:

With the increment of drug-resistant bacteria and the slow development of novel antibiotics, antimicrobial peptides have gained increasing attention as a potential antibiotic alternative. They not only displayed a broad-spectrum antimicrobial activity but also were difficult to induce resistance development because of their unique membrane-lytic activity. Herein, to improve the limitations of Anoplin, the N-methyl amino acids were first used to replace the amino acids of Anoplin at sensitive enzymatic cleave sites (Leu, Ile, Lys and Arg). Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105453DOI Listing

Targeted and untargeted analysis of secondary metabolites to monitor growth and quorum sensing inhibition for methicillin-resistant Staphylococcus aureus (MRSA).

J Microbiol Methods 2020 Jul 7:106000. Epub 2020 Jul 7.

Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA. Electronic address:

Drug resistant infections are an increasing problem world-wide, responsible for an estimated 700,000 annual mortalities. The use of antibiotics to treat such infections has resulted in the development of resistant bacterial pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). One potential alternative strategy for treating drug resistant bacterial infections is to inhibit the production of toxins, thereby making the bacteria less harmful to the host, a so called "anti-virulence" approach. Read More

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http://dx.doi.org/10.1016/j.mimet.2020.106000DOI Listing

Oxytetracycline and ciprofloxacin exposure altered the composition of protistan consumers in an agricultural soil.

Environ Sci Technol 2020 Jul 10. Epub 2020 Jul 10.

Protists, an integral component of soil microbiome, are one of the main predators of bacteria. Bacteria can produce toxic secondary metabolites e.g. Read More

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http://dx.doi.org/10.1021/acs.est.0c02531DOI Listing

COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium.

Am J Transplant 2020 Jul 10. Epub 2020 Jul 10.

Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Kidney transplant recipients may be at high risk of developing critical COVID-19 illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney transplant recipients at 12 transplant centers in the US, Italy and Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression and treatment strategies were reviewed and predictors of poor clinical outcomes were determined through multivariable analyses. Read More

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http://dx.doi.org/10.1111/ajt.16185DOI Listing

Interrupted Time-Series Analysis to Evaluate the Impact of a National Antimicrobial Stewardship Campaign on Antibiotic Prescribing: A Typical Practice in China's Primary Care.

Clin Infect Dis 2020 Jul 10. Epub 2020 Jul 10.

Department of Social Medicine and Health Management, School of Public Health, Huazhong University of Science and Technology, Wuhan, P. R. China.

Background: After implementing the 2011 national antimicrobial stewardship campaign, few studies focused on evaluating its effect in China's primary care facilities.

Methods: We randomly selected 11 community health centers in Shenzhen, China, and collected all outpatient prescriptions of these centers from 2010-2015. To evaluate the impact of local interventions on antibiotic prescribing, we used a segmented regression model of interrupted time series to analyze seven outcomes, i. Read More

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http://dx.doi.org/10.1093/cid/ciaa962DOI Listing

Quality of medicines for life-threatening pregnancy complications in low- and middle-income countries: A systematic review.

PLoS One 2020 10;15(7):e0236060. Epub 2020 Jul 10.

UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

Background: There are concerns about the quality of medicines available in low- and middle-income countries (LMIC) to manage hemorrhage, pre-eclampsia/eclampsia and sepsis. We aimed to identify, critically appraise, and synthesize the findings of studies on the quality of these three types of medicines available in LMIC.

Methods: This systematic review searched Medline, EMBASE and LILACS (from inception to 25 May 2020) for studies on the quality of selected medicines available in LMIC that provided at least the amount of active pharmaceutical ingredient. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236060PLOS

A molecular and epidemiological study of Vibrio cholerae isolates from cholera outbreaks in southern Ghana.

PLoS One 2020 10;15(7):e0236016. Epub 2020 Jul 10.

Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.

Cholera remains a major global public health threat and continuous emergence of new Vibrio cholerae strains is of major concern. We conducted a molecular epidemiological study to detect virulence markers and antimicrobial resistance patterns of V. cholerae isolates obtained from the 2012-2015 cholera outbreaks in Ghana. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236016PLOS

Antibiotic prescription patterns for treating dental infections in children among general and pediatric dentists in teaching institutions of Karachi, Pakistan.

PLoS One 2020 10;15(7):e0235671. Epub 2020 Jul 10.

Department of Community Medicine, Baqai Medical University, Karachi, Pakistan.

Background: Antibiotics are regularly prescribed by dental professionals in their practice, for the purpose of dental treatment as well as for the prevention of infection. The inappropriate use of antibiotics is a significant factor in the rise of antibiotic resistance. There is an immediate need for the advancement of prescribing guidelines and instructive polices to encourage the rational and appropriate utilization of medications especially antibiotics in dentistry. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235671PLOS

Response to the Comment on "Are Postoperative Intravenous Antibiotics Indicated After Laparoscopic Appendicectomy for Simple Appendicitis? A Prospective Double-blinded Randomized Controlled Trial".

Ann Surg 2020 Jul 7. Epub 2020 Jul 7.

Department of Paediatric Surgery and Surgical Simulation, Monash Children's Hospital, Melbourne, Australia Department of Paediatrics, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia Department of Surgery, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1097/SLA.0000000000003864DOI Listing

Post-ERCP cholecystitis: Incidence and risk factors.

J Chin Med Assoc 2020 Jun 22. Epub 2020 Jun 22.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: For decades, endoscopic retrograde cholangiopancreatography (ERCP) has been widely performed as a diagnostic and therapeutic procedure for biliary and pancreatic diseases. Complications of ERCP include pancreatitis, hemorrhage, perforation, cholangitis, and cholecystitis. There are few studies that focus on the incidence of post-ERCP cholecystitis and its potential risk factors. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000383DOI Listing

Acute Hematogenous Osteomyelitis of the Scapula: A Case Report.

JBJS Case Connect 2020 Jul-Sep;10(3):e2000016

1University of Chicago Medical Center-Department of Orthopaedic Surgery, Comer Children's Hospital, Chicago, Illinois 2University of Indiana Medical Center-Department of Orthopaedic Surgery, Riley Hospital for Children, Indianapolis, Indiana.

Case: We present the case of a previously healthy 4-year-old boy with aggressive acute hematogenous osteomyelitis (AHO) of the scapula. Despite only 3 days of symptoms, he had a large abscess, prolonged bacteremia, and significant bony destruction. He required multiple debridements and intravenous antibiotics to control the infection but ultimately had full restoration of bony anatomy and normal function. Read More

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http://dx.doi.org/10.2106/JBJS.CC.20.00016DOI Listing

Antibiotic-Impregnated Intramedullary Cement Nail-Induced Acute Generalized Exanthematous Pustulosis and Septic Shock: A Case Report.

JBJS Case Connect 2020 Apr-Jun;10(2):e0441

1Department of Orthopedic Surgery, University of California-San Diego, San Diego, California.

Case: A 28-year-old woman with an infected proximal femur nonunion was treated with an antibiotic-coated intramedullary nail. Shortly after discharge, the patient presented to the emergency department and was readmitted with a morbilliform rash sparing the left lower extremity. She became hemodynamically unstable, despite cessation of intravenous antibiotics, requiring transfer to the intensive care unit and urgent removal of her antibiotic nail. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00441DOI Listing

Open Obturator Hip Dislocation: A Case Report and Review of the Literature.

JBJS Case Connect 2020 Apr-Jun;10(2):e0149

1Department of Orthopaedic Surgery, Wake Forest Baptist Medical Center, Winston Salem, North Carolina.

Case: An open obturator dislocation with associated pelvic ring injury and perineal wound underwent fixation and aggressive debridement. Despite this, the patient proceeded to infection requiring additional debridements and prolonged intravenous antibiotics. At 18 months postinjury, the patient developed avascular necrosis and significant heterotopic ossification; however, she was able to ambulate. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00149DOI Listing

The "ART" of Facial Filler Injections: Avoid, Recognize and Treat Hyaluronic Acid-induced Complications.

J Cosmet Dermatol 2020 Jul 10. Epub 2020 Jul 10.

Universitair Ziekenhuis Brussel (UZ Brussel), Department of Plastic and Reconstructive Surgery, Laarbeeklaan 101, 1090, Brussels, Belgium.

Hyaluronic acid (HA) fillers are frequently used for cosmetic purposes as volumizers or as wrinkle fillers. One of the major advantages of hyaluronic acid use is the possibility to neutralize it by using hyaluronidase should complications occur. A case of a 21-year old female patient is presented, in whom a hyaluronic acid injection-induced vascular occlusion was seen four days after the initial injection, with increasing pain and severe signs of ischemia. Read More

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http://dx.doi.org/10.1111/jocd.13611DOI Listing

FtsZ-Independent Mechanism of Division Inhibition by the Small Molecule PC190723 in Escherichia coli.

Adv Biosyst 2019 Nov 21;3(11):e1900021. Epub 2019 Jun 21.

Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.

While cell division is a critical process in cellular proliferation, very few antibiotics have been identified that target the bacterial cell-division machinery. Recent studies have shown that the small molecule PC190723 inhibits cell division in several Gram-positive bacteria, with a hypothesized mechanism of action involving direct targeting of the tubulin homolog FtsZ, which is essential for division in virtually all bacterial species. Here, it is shown that PC190723 also inhibits cell division in the Gram-negative bacterium Escherichia coli if the outer membrane permeability barrier is compromised genetically or chemically. Read More

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http://dx.doi.org/10.1002/adbi.201900021DOI Listing
November 2019

Synergistic and antagonistic interactions of triclosan with various antibiotics in bacteria.

J Environ Sci Health C Toxicol Carcinog 2020 Jul 10:1-17. Epub 2020 Jul 10.

Biological Sciences Department, University of Memphis, Memphis, Tennessee, USA.

Triclosan (TCS), a well-studied antimicrobial compound and an environmental pollutant, is present in many household products. A systematic survey of TCS-antibiotic-bacteria interactions is lacking. We wish to understand the origin of such interactions by testing 16 phylogenetically well-characterized bacteria for their sensitivities to 6 different classes of antibiotics with or without the presence of TCS. Read More

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http://dx.doi.org/10.1080/26896583.2020.1781494DOI Listing
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