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Pathogens 2022 Jun 12;11(6). Epub 2022 Jun 12.

Department of Microbiology and Immunology, Institute of Medical Science, Collegium Medicum, Jan Kochanowski University, IX Wieków Kielc 19A, 25-317 Kielce, Poland.

() is one of the most frequent opportunistic microorganisms causing infections in oncological patients, especially those with neutropenia. Through its ability to adapt to difficult environmental conditions and high intrinsic resistance to antibiotics, it successfully adapts and survives in the hospital environment, causing sporadic infections and outbreaks. It produces a variety of virulence factors that damage host cells, evade host immune responses, and permit colonization and infections of hospitalized patients, who usually develop blood stream, respiratory, urinary tract and skin infections. Read More

Antibiotics (Basel) 2022 Jun 16;11(6). Epub 2022 Jun 16.

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.

It has been suggested that the COVID-19 pandemic led to an increase in self-medication practices across the world. Yet, there is no up-to-date synthesized evidence on the prevalence of self-medication that is attributable to the pandemic. This study aimed to conduct a systematic literature review on the prevalence and correlates of self-medication for the prevention and treatment of COVID-19 globally. Read More

Antibiotics (Basel) 2022 Jun 10;11(6). Epub 2022 Jun 10.

Center for Global Health, Zhejiang University School of Medicine, Hangzhou 310000, China.

Educational interventions are considered an important component of antibiotic stewardship, but their effect has not been systematically evaluated in outpatient settings in China. This research aims to evaluate the effectiveness of educational interventions for health workers on antibiotic prescribing rates in Chinese outpatient settings. Eight databases were searched for relevant randomized clinical trials, non-randomized trials, controlled before-after studies and interrupted time-series studies from January 2001 to July 2021. Read More

Antibiotics (Basel) 2022 May 31;11(6). Epub 2022 May 31.

Mandai Wildlife Group, Conservation, Research, and Veterinary Department, Singapore 259569, Singapore.

In avian medicine, the use of antibiotic dosing regimens based on species-specific pharmacological studies is ideal. However, due to a lack of such studies, dose extrapolation, which may cause inefficacy and toxicity, is common practice. Multiple searches were performed using the PubMed and Web of Science databases to extract relevant pharmacological studies performed in exotic avian species. Read More

Biosensors (Basel) 2022 May 27;12(6). Epub 2022 May 27.

Key Laboratory of Fermentation Engineering (Ministry of Education), College of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, China.

Due to their advantages of good flexibility, low cost, simple operations, and small equipment size, electrochemical sensors have been commonly employed in food safety. However, when they are applied to detect various food or drug samples, their stability and specificity can be greatly influenced by the complex matrix. By combining electrochemical sensors with molecular imprinting techniques (MIT), they will be endowed with new functions of specific recognition and separation, which make them powerful tools in analytical fields. Read More

Bioengineering (Basel) 2022 Jun 10;9(6). Epub 2022 Jun 10.

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Nisin, a typical lantibiotic, has robust antimicrobial activity combined with limited cytotoxicity, and the development of resistance to it is slow. These properties make nisin a promising antimicrobial agent to control pathogenic microorganisms in dairy foods. However, its low solubility, poor stability and short half-life at neutral pH limit its application within the dairy industry. Read More

Pediatr Emerg Care 2022 Jun 22. Epub 2022 Jun 22.

Division of Hematology/Oncology, Department of Pediatrics, East Carolina University, Greenville, NC.

Objective: We assessed whether prior communication between pediatric hematologists and emergency department (ED) providers reduced time to administration of parenteral antibiotics for children with sickle cell disease presenting with fever.

Methods: Patients 2 months to 21 years of age were retrospectively identified if they were followed up at our center's pediatric hematology clinic and presented to the pediatric ED with fever. Emergency department-hematology communication before patient arrival was ascertained by chart review. Read More

Clin Microbiol Rev 2022 Jun 21:e0021121. Epub 2022 Jun 21.

International Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh.

Cholera, caused by Vibrio cholerae, persists in developing countries due to inadequate access to safe water, sanitation, and hygiene. There are approximately 4 million cases and 143,000 deaths each year due to cholera. The disease is transmitted fecally-orally via contaminated food or water. Read More

Int J Infect Dis 2022 Jun 17. Epub 2022 Jun 17.

Program in Translational Medicine, National Chung Hsing University, Taichung City, Taiwan; Rong Hsing Research Center For Translational Medicine, National Chung Hsing University, Taichung City, Taiwan; Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan. Electronic address:

Introduction: Inadequate treatment of scrub typhus results in severe complications such as septic shock and is also associated with a high median mortality rate of 6%. However, there has been no conclusive evidence about the superiority of different antibiotics in managing scrub typhus in terms of efficacy and tolerability.

Methods: The current network meta-analysis (NMA) was conducted using the frequentist method. Read More

Drugs Context 2022 31;11. Epub 2022 May 31.

SKiN Centre for Dermatology, Peterborough, ON, Canada.

Acne vulgaris is a prevalent dermatological condition worldwide but is especially challenging to treat in individuals with skin of colour (SOC). Corresponding to Fitzpatrick skin phototypes III-VI, people of African, Asian, Middle Eastern and Hispanic ethnicity are considered to have SOC. With the additional risk of postinflammatory hyperpigmentation (PIH) as a consequence of inflammatory acne or its respective treatment, managing acne in this population holds significant importance. Read More

Am J Emerg Med 2022 Jun 11;58:235-244. Epub 2022 Jun 11.

SAUSHEC, Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA. Electronic address:

Introduction: Acute chest syndrome (ACS) in sickle cell disease (SCD) is a serious condition that carries with it a high rate of morbidity and mortality.

Objective: This review highlights the pearls and pitfalls of ACS in SCD, including diagnosis and management in the emergency department (ED) based on current evidence.

Discussion: ACS is defined by respiratory symptoms and/or fever and a new radiodensity on chest imaging in a patient with SCD. Read More

Front Cell Infect Microbiol 2022 30;12:883107. Epub 2022 May 30.

National Engineering Laboratory of Biological Feed Safety and Pollution Prevention and Control, Zhejiang University, Hangzhou, China.

Early weaning of piglets is an important strategy for improving the production efficiency of sows in modern intensive farming systems. However, due to multiple stressors such as physiological, environmental and social challenges, postweaning syndrome in piglets often occurs during early weaning period, and postweaning diarrhea (PWD) is a serious threat to piglet health, resulting in high mortality. Early weaning disrupts the intestinal barrier function of piglets, disturbs the homeostasis of gut microbiota, and destroys the intestinal chemical, mechanical and immunological barriers, which is one of the main causes of PWD in piglets. Read More

Microb Pathog 2022 Jun 13;169:105637. Epub 2022 Jun 13.

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia. Electronic address:

Melioidosis is endemic in Southeast Asia and northern Australia. The causative agent of melioidosis is a Gram-negative bacterium, Burkholderia pseudomallei. Its invasion can be fatal if melioidosis is not treated promptly. Read More

Adv Skin Wound Care 2022 Jun;35(6):306-313

General Purpose: To provide comprehensive information about breast ulcers to facilitate accurate diagnosis and treatment of these lesions.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant will:1. Read More

Age Ageing 2022 Jun;51(6)

Department of Medicine for Older People, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.

Background: a suspected urinary tract infection (UTI) is the most common reason to prescribe antibiotics in a frail older patient. Frequently, antibiotics are prescribed unnecessarily. To increase appropriate antibiotic use for UTIs through antibiotic stewardship interventions, we need to thoroughly understand the factors that contribute to these prescribing decisions. Read More

J Food Drug Anal 2020 Dec 15;28(4):539-557. Epub 2020 Dec 15.

Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, 20224, Taiwan.

Carbon quantum dots (CQDs) are novel nanomaterials with interesting physical and chemical properties, which are intensely studied only in the last decade. Unique properties, such as its inherent fluorescent property, high resistance to photobleaching, high surface area, ease of synthesis, flexible choice of precursor, and surface tunability enable CQDs for promising application in biosensing. Therefore, it is highly useful in clinical, forensic, medical, food and drug analyses, disease diagnosis, and various other fields of biosensing. Read More

Sci Total Environ 2022 Sep 6;838(Pt 4):156544. Epub 2022 Jun 6.

Key Laboratory of Pollution Processes and Environmental Criteria of the Ministry of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:

This study aims to discuss the following: (1) occurrence and proliferation of antibiotic resistance in wastewater treatment plants (WWTPs); (2) factors influencing antibiotic resistance bacteria and genes in WWTPs; (3) tools to assess antibiotic resistance in WWTPs; (4) environmental contamination of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) from WWTPs; (5) effects of ARB and ARGs from WWTPs on human health; and (6) treatment strategies. In general, resistant and multi-resistant bacteria, including Enterobacteriaceae, Pseudomonas aeruginosa, and Escherichia coli, exist in various processes of WWTPs. The existence of ARB and ARGs results from the high concentration of antibiotics in wastewater, which promote selective pressures on the local bacteria present in WWTPs. Read More

BMJ Case Rep 2022 Jun 6;15(6). Epub 2022 Jun 6.

Internal Medicine, Kasturba Medical College Manipal, Manipal, Karnataka, India.

Melioidosis is an emerging infectious disease with highest predominance in Southeast Asia, but it has a significantly lower incidence across other parts of the globe. The most common systemic involvement seen in melioidosis is pulmonary, followed by multiple visceral and cutaneous abscesses. Infrequently, melioidosis manifests with atypical presentations such as spontaneous bacterial peritonitis (SBP), acute pyogenic meningitis or septic arthritis. Read More

J Surg Case Rep 2022 May 27;2022(5):rjac225. Epub 2022 May 27.

Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.

Infected cephalhaematomas are rare and can lead to complications such as sepsis, meningitis and osteomyelitis. We present an infected cephalhaematoma in a neonate with resultant underlying osteomyelitis and a review of the literature. Our patient presented 6 days following birth with a fever and a swelling consistent with cephalhaematoma. Read More

Microbiol Res 2022 Aug 27;261:127079. Epub 2022 May 27.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad hydrolytic activity, pathogens expressing NDM-1 often harbor other antibiotic-resistant genes, further promoting the pervasion of multi-resistant clinical isolates and making clinically available drugs scantier. Despite the urgent need for NDM-1 inhibitors, there is no approved drug in clinic. Read More

J Environ Sci Health A Tox Hazard Subst Environ Eng 2022 Jun 3:1-21. Epub 2022 Jun 3.

Application and Research Center for Advanced Studies, T. C. Istanbul Aydin University, Istanbul, Turkey.

Pollution by plastics and antibiotics are emerging issues in the areas of the environment and human health. In recent years, several studies have documented the widespread occurrence of plastic particles in various environmental, as well as human, systems, and much research has focused on possible interactions of contaminants with microplastics. Thus, the co-occurrence of plastics and antibiotics has caused another global problem for the environment and human health. Read More

J Hazard Mater 2022 08 4;435:129067. Epub 2022 May 4.

College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China.

Antibiotic resistance genes (ARGs) pollution has been considered as one of the most significant emerging environmental and health challenges in the 21st century, many efforts have been paid to control the proliferation and dissemination of ARGs in the environment. Among them, the biochar performs a positive effect in reducing the abundance of ARGs during different environmental governance processes and has shown great application prospects in controlling the ARGs. Although there are increasing studies on employing biochar to control ARGs, there is still a lack of review paper on this hotspot. Read More

Appl Microbiol Biotechnol 2022 Jun 1;106(11):3957-3972. Epub 2022 Jun 1.

Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.

Prior to the nineteenth century, infectious disease was one of the leading causes of death. Human life expectancy has roughly doubled over the past century as a result of the development of antibiotics and vaccines. However, the emergence of antibiotic-resistant superbugs brings new challenges. Read More

Microb Pathog 2022 Jul 26;168:105606. Epub 2022 May 26.

Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA Deemed University, Thanjavur, India; School of Arts, Science, Humanities and Education, SASTRA Deemed University, Thanjavur, India. Electronic address:

Vaginosis is a condition experienced by most women at least once in their lifetime. This condition arises due to the imbalance in the microbiome of the vaginal ecosystem. Most of the pathogens of this disease are organisms which are commonly found in a normal healthy vagina. Read More

Infect Agent Cancer 2022 May 30;17(1):23. Epub 2022 May 30.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, 2052, Australia.

Background: The aim of this review is to consider whether multiple pathogens have roles in prostate cancer.

Methods: We have reviewed case control studies in which infectious pathogens in prostate cancer were compared to normal and benign prostate tissues. We also reviewed additional evidence from relevant published articles. Read More

Life (Basel) 2022 May 12;12(5). Epub 2022 May 12.

Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 041 81 Košice, Slovakia.

Alterations in the composition of the intestinal microbiome, also known as dysbiosis, are the result of many factors such as diet, antibiotics, stress, diseases, etc. There are currently several ways to modulate intestinal microbiome such as dietary modulation, the use of antimicrobials, prebiotics, probiotics, postbiotics, and synbiotics. Faecal microbiota transplantation (FMT) represents one new method of gut microbiota modulation in humans with the aim of reconstructing the intestinal microbiome of the recipient. Read More

Int J Mol Sci 2022 May 18;23(10). Epub 2022 May 18.

Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, Soseaua Panduri, 030018 Bucharest, Romania.

In the context of the new life-threatening COVID-19 pandemic caused by the SARS-CoV-2 virus, finding new antiviral and antimicrobial compounds is a priority in current research. Pyridine is a privileged nucleus among heterocycles; its compounds have been noted for their therapeutic properties, such as antimicrobial, antiviral, antitumor, analgesic, anticonvulsant, anti-inflammatory, antioxidant, anti-Alzheimer's, anti-ulcer or antidiabetic. It is known that a pyridine compound, which also contains a heterocycle, has improved therapeutic properties. Read More

Antibiotics (Basel) 2022 May 11;11(5). Epub 2022 May 11.

Department of Medicine, Division of Infectious Diseases, Banner University Medical Center-Tucson and South, University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA.

Globally, antimicrobial resistance has emerged as a significant threat. A comprehensive plan is required to combat antimicrobial resistance. There have been national and international efforts to address this global health problem, but much work remains. Read More

Antibiotics (Basel) 2022 Apr 24;11(5). Epub 2022 Apr 24.

Department of Pharmaceutics, Dr. Rajendra Gode College of pharmacy, Malkapur 443101, India.

A major global health risk has been witnessed with the development of drug-resistant bacteria and multidrug-resistant pathogens linked to significant mortality. Coumarins are heterocyclic compounds belonging to the benzophenone class enriched in different plants. Coumarins and their derivatives have a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumour, and enzyme inhibitory effects. Read More

Animals (Basel) 2022 May 10;12(10). Epub 2022 May 10.

Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-719 Olsztyn, Poland.

To meet the nutritional requirements of our growing population, animal production must double by 2050, and due to the exhaustion of environmental capacity, any growth will have to come from aquaculture. Aquaculture is currently undergoing a dynamic development, but the intensification of production increases the risk of bacterial diseases. In recent years, there has been a drastic development in the resistance of pathogenic bacteria to antibiotics and chemotherapeutic agents approved for use, which has also taken place in aquaculture. Read More