646,144 results match your criteria Anti-inflammatory & anti-allergy agents in medicinal chemistry[Journal]


Discovery of coumarin Mannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease.

Eur J Med Chem 2019 Apr 12;173:203-212. Epub 2019 Apr 12.

Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. Electronic address:

Due to the complexity of the pathogenesis of Parkinson's disease (PD), multimodal treatment may achieve better results. In this study, a series of coumarin Mannich base derivatives were designed and synthesized as multifunctional agents for PD treatment. Among the derivatives, 3-(3-(dimethylamino)propanoyl)-7-hydroxy-5-methyl- 2H-chromen-2-one hydrochloride (24) exhibited the most potent and selective hMAO-B inhibitory activity, and anti-inflammatory and neuroprotective effects in the in vitro studies. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.016DOI Listing

Oxytocin in the tumor microenvironment is associated with lower inflammation and longer survival in advanced epithelial ovarian cancer patients.

Psychoneuroendocrinology 2019 Apr 6;106:244-251. Epub 2019 Apr 6.

Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, United States.

Background: Prior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also has anti-inflammatory properties that have not been examined in cancer. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.04.007DOI Listing
April 2019
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Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ.

Int Immunopharmacol 2019 Apr 17;72:301-307. Epub 2019 Apr 17.

First Clinical Hospital of Harbin Medical University, Harbin 150001, China. Electronic address:

Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridonin. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.006DOI Listing

Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects.

Int Immunopharmacol 2019 Apr 17;72:292-300. Epub 2019 Apr 17.

Department of Immunology, Medical College of Nanchang University, Nanchang 330000, China. Electronic address:

Curcumin is a natural herbal product that has been popularly used to treat autoimmune diseases in China; however, its effects on rheumatoid arthritis and its mechanism are not clear. The main purposes of this study are to explore the therapeutic effects of curcumin on collagen-induced arthritis (CIA) rats and the pharmacological mechanism. In the present study, CIA rats were established by injecting bovine type II collagen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193079
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http://dx.doi.org/10.1016/j.intimp.2019.04.027DOI Listing
April 2019
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Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization.

Int Immunopharmacol 2019 Apr 17;72:264-274. Epub 2019 Apr 17.

Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei, China. Electronic address:

Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To investigate the effects and possible mechanism of EVs in UC treatment, we established an in vitro model using lipopolysaccharide (LPS)-treated macrophages and an in vivo dextran sulfate sodium (DSS)-induced mouse model to mimic UC. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.020DOI Listing

Unraveling the solubilization and cytotoxicity study of poorly water-soluble anti-inflammatory drug in aqueous Gemini surfactants solution with physicochemical characterization and simulation study.

Colloids Surf B Biointerfaces 2019 Mar 28;179:437-444. Epub 2019 Mar 28.

Applied Chemistry Department, Sardar Vallabhbhai National Institute of Technology (SVNIT), Ichchhanath, Surat, 395 007, Gujarat, India. Electronic address:

This work investigates the use of quaternary ammonium based Gemini surfactants (GS) to examine the solubilization and stabilization of a poorly water soluble anti-inflammatory drug Diclofenac (Df). Here we demonstrate the effect of pH on the suspension profile of Df release where it exhibits maximum solubility and absorbance at pH = 10. Interaction process of such cationic GS with Df have been systematically characterized using tensiometry and UV-vis spectroscopy techniques from pre-micellar to post-micellar regions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193020
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http://dx.doi.org/10.1016/j.colsurfb.2019.03.059DOI Listing
March 2019
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Preliminary studies on the anti-osteoporosis activity of Baohuoside I.

Biomed Pharmacother 2019 Apr 17;115:108850. Epub 2019 Apr 17.

Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

The aim of the present study was to investigate the anti-osteoporotic activity of Baohuoside I, an active component of Herba Epimedii. Effects of Baohuoside I on the differentiation of BMSCs and the formation of adipocytes were evaluated using alkaline phosphatase staining and methylene blue staining method, respectively. Osteoporosis model was established in ovariectomized rats prior to the measurement of the serum SOD and MDA levels as well as the expression of inflammatory cytokines protein in the rats' tissues after treatment with Baohuoside I using ELISA assay kits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183753
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http://dx.doi.org/10.1016/j.biopha.2019.108850DOI Listing
April 2019
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Nanoemulsion strategy of pioglitazone for the treatment of skin inflammatory diseases.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.017DOI Listing
April 2019
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Cytokine production in allergic and Trichuris trichiura-infected children from an urban region of the Brazilian northeast.

Parasitol Int 2019 Apr 17. Epub 2019 Apr 17.

Immunology Section, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, Brazil. Electronic address:

The relationship between the cellular immune response during Trichuris trichiura infection and asthma has not yet been established. In this study, the cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17A were evaluated in asthmatic children harboring T. trichiura. Read More

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http://dx.doi.org/10.1016/j.parint.2019.04.015DOI Listing

Varieties of immunity activities and gut contents in tilapia with seasonal changes.

Fish Shellfish Immunol 2019 Apr 17. Epub 2019 Apr 17.

Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, No. 9 Shanshui East Rd., Wuxi, Jiangsu, 214081, China. Electronic address:

We performed 16S rDNA sequencing of tilapia fecal samples to analyze changes in tilapia gut contents after cultivation of the fish in the presence of sandwich-like floating beds of Chinese medicinal herbs (5 and 10% planting-areas; 5% Polygonum cuspidatum). The interactive effects between water quality and blood and hepatic pro- and anti-inflammatory concentrations were also assessed. Our results showed that the water quality (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193028
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http://dx.doi.org/10.1016/j.fsi.2019.04.042DOI Listing
April 2019
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MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 17. Epub 2019 Apr 17.

Scuola Superiore Sant'Anna, Institute of Life Sciences, 56124 Pisa, Italy. Electronic address:

The capacity of inducing angiogenesis is a recognized hallmark of cancer cells. The cancer microenvironment, characterized by hypoxia and inflammatory signals, promotes proliferation, migration and activation of quiescent endothelial cells (EC) from surrounding vascular network. Current anti-angiogenic drugs present side effects, temporary efficacy, and issues of primary resistance, thereby calling for the identification of new therapeutic targets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193011
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http://dx.doi.org/10.1016/j.bbadis.2019.04.008DOI Listing
April 2019
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Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines.

Toxicology 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Toxicology Department, Utrecht University, Yalelaan 104, 3584 CM, Utrecht, the Netherlands.

Resveratrol is a plant-derived polyphenol that is known for its anti-inflammatory and anti-tumorigenic properties in in vitro and in vivo models. Recent studies show that some resveratrol analogues might be more potent anti-tumor agents, which may partly be attributed to their ability to activate the aryl hydrocarbon receptor (AHR). Here, the anti-tumorigenic properties of resveratrol and structural analogues oxyresveratrol, pinostilbene, pterostilbene and tetramethoxystilbene (TMS) were studied in vitro, using in the malignant human MCF-7 breast cancer cell line and non-tumorigenic breast epithelial cell line MCF-10 A. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.009DOI Listing

Monosaccharide composition influence and immunomodulatory effects of probiotic exopolysaccharides.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Department of Food Science and Nutrition, Meiho University, Taiwan. Electronic address:

Exopolysaccharides (EPSs) are metabolites of probiotics that have gained wide interest recently. A strain of Lactobacillus reuteri Mh-001 with high exopolysaccharide (EPS) production ability was isolated, identified, and were used to investigate the anti-inflammatory effects of the EPSs. Among the three unpurified EPSs, RAW246. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.109DOI Listing

The flavonoid chrysin protects against zearalenone induced reproductive toxicity in male mice.

Toxicon 2019 Apr 17. Epub 2019 Apr 17.

Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas (Laftambio Pampa), Universidade Federal Do Pampa, Campus Itaqui, 97650-000, Itaqui, RS, Brazil.

The mycotoxin zearalenone (ZEA) has strong estrogenic effects and elicits reproductive toxicity. Chrysin is a natural flavonoid found in many plant and has a broad range of pharmacological activities, including anticancer, antioxidant and anti-inflammatory. The present study aimed to investigate the potential protective effects of chrysin against ZEA toxicity. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.04.004DOI Listing

Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, China. Electronic address:

Rheumatoid arthritis fibroblast-like synoviocytes play an essential role in the occurrence and progression of rheumatoid arthritis. As the main pharmacologically active components of Aralia taibaiensis, total saponins, particularly triterpenoid saponins, have been shown to possess multiple pharmacological activities including relieving rheumatism. However, the effect of araloside A, a triterpenoid saponin extracted from the root bark of Aralia taibaiensis, on rheumatoid arthritis remains unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.025DOI Listing

Effect of Combination NSAID and NBUVB treatment in Non-Photoadapters - A Pilot Study.

Photodermatol Photoimmunol Photomed 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, Henry Ford Hospital, Detroit, MI.

Background: Vitiligo is a disorder of dyspigmentation that can impact quality of life. While narrow band ultraviolet B (NBUVB) is an effective treatment for vitiligo, a sub-set of patients are unable to respond to phototherapy as they cannot photoadapt. However, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to increase the minimal erythema dose. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/phpp.12476
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http://dx.doi.org/10.1111/phpp.12476DOI Listing
April 2019
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Successful management of 3 dogs with colonic pythiosis using itraconzaole, terbinafine, and prednisone.

J Vet Intern Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.

Gastrointestinal (GI) pythiosis is a severe and often fatal disease in dogs that traditionally has been poorly responsive to medical treatment. Although aggressive surgical resection with wide margins is the most consistently effective treatment, lesion location and extent often preclude complete resection. Recently, it has been suggested that the addition of anti-inflammatory doses of corticosteroids may improve outcome in dogs with nonresectable GI pythiosis. Read More

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http://dx.doi.org/10.1111/jvim.15506DOI Listing
April 2019
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New potentials for 3-hydroxy-3-methyl-glutaryl-coenzymeA reductase inhibitors: Possible applications in retarding diabetic complications.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.

The prevalence of diabetes mellitus is increasing all over the world and it is apparent that treatment of diabetic complications has the same importance as primary diabetes treatment and glycemic control. Diabetic complications occur as a result of prolonged hyperglycemia and its consequences, such as advanced glycation end products and reactive oxygen species. Impairment of lipid profile is also contributed to worsening diabetic complications. Read More

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http://dx.doi.org/10.1002/jcp.28682DOI Listing

Extracorporeal Shockwave Therapy Combined with Drug Therapy in Chronic Pelvic Pain Syndrome - A Randomized Clinical Trial.

Urol J 2019 Apr 20. Epub 2019 Apr 20.

Department of Urology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS) is a nonspecific pelvic pain in the absence of signs of infection or other obvious local pathology for at least 3 of the last 6 months. The evidence for treatment is limited so the aim of this study is to investigate the effect of extracorporeal shock wave therapy (ESWT) combined with pharmacotherapy in the treatment of CP/CPPS.

Materials And Methods: In this randomized clinical  trial, 31 patients with CP/CPPS were investigated in two groups: the intervention group (n=16) was treated with a combination of an alfa-blocker, an anti-inflammatory agent, a muscle relaxant and a short course of antibiotic in combination with 4 sessions of focused ESWT (a protocol of 3000 impulses, 0. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4673DOI Listing
April 2019
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Pro- and anti-inflammatory eicosanoids in psoriatic arthritis.

Metabolomics 2019 Apr 19;15(4):65. Epub 2019 Apr 19.

Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.

Introduction: Eicosanoids are biological lipids that serve as both activators and suppressors of inflammation. Eicosanoid pathways are implicated in synovitis and joint destruction in inflammatory arthritis, yet they might also have a protective function, underscoring the need for a comprehensive understanding of how eicosanoid pathways might be imbalanced. Until recently, sensitive and scalable methods for detecting and quantifying a high number of eicosanoids have not been available. Read More

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http://dx.doi.org/10.1007/s11306-019-1527-0DOI Listing

A constitutional activating MET mutation makes the genetic link between malignancies and chronic inflammatory diseases.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Inserm U1165, University Paris 7.

Purpose: The genesis of all cancers results from an accumulation of mutations, constitutional and/or acquired when induced by external mutagenic factors. High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic changes.

Experimental Design: Here, we proposed an innovative individual approach by studying tissue samples from a young woman with an unusual association of breast cancer, polycythemia vera and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3261DOI Listing

Quantitative analysis of medicinal plants used to treat musculoskeletal ailments by non-institutionally trained siddha practitioners of Virudhunagar district, Tamil Nadu, India.

J Ayurveda Integr Med 2019 Apr 16. Epub 2019 Apr 16.

Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Nungambakkam, Chennai, Tamil Nadu, 600 034, India. Electronic address:

Background: Siddha is one of the traditional medical systems of India; previous ethnobotanical survey in Virudhunagar district indicated a high consensus for treating musculoskeletal ailments.

Objectives: This study was aimed to quantitatively document the medicinal plants used to treat musculoskeletal ailments by non-institutionally trained siddha practitioners of Virudhunagar district, Tamil Nadu, India.

Materials And Methods: This work was the outcome of free-list interviews conducted among 45 informants between April 2016 and January 2017. Read More

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http://dx.doi.org/10.1016/j.jaim.2018.11.005DOI Listing

Effects of epigallocatechin-3-gallate on the HMGB1/RAGE pathway in PM-exposed asthmatic rats.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, Children's Hospital Affiliated of Zhengzhou University, No.33 Long hu Wai huan East Road, Zhengzhou, 450018, Henan, China. Electronic address:

Current studies have shown that long-term exposure to fine particulate matter (PM) can aggravate lung injury in asthmatic children. The HMGB1/RAGE pathway may play an important role, but few studies on the HMGB1/RAGE signaling pathway in PM-induced asthma have been performed. Epigallocatechin-3-gallate (EGCG), which has antioxidant, anti-inflammatory and immunomodulatory effects, has not been examined in studies at home and abroad. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.165DOI Listing

The use of aloe vera in cancer radiation: An updated comprehensive review.

Complement Ther Clin Pract 2019 May 31;35:126-130. Epub 2019 Jan 31.

St. John Fisher College Wegmans School of Pharmacy, 3690 East Avenue, Rochester, NY, 14618, USA.

Introduction: Many cancer patients require radiation therapy and often experience adverse effects including erythema, itching, and pain. Aloe vera has been studied for its potential use in the prevention and treatment of radiation related adverse effects as it possesses a variety of properties and is considered an antioxidant and anti-inflammatory agent. Multiple controlled trials have been performed in order to evaluate the efficacy of aloe vera for the prevention and treatment of radiation side effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17443881183051
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http://dx.doi.org/10.1016/j.ctcp.2019.01.013DOI Listing
May 2019
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An In Vitro Study of the Influence of Extracts on the Microbiota Modulation Process, In Patients with Hypertension.

Pharmaceutics 2019 Apr 18;11(4). Epub 2019 Apr 18.

Department of Genetics, ICUB-Research Institute of the University of Bucharest, 36-46 Bd. M. Kogalniceanu, 5th District, 050107 Bucharest, Romania.

The multiple causes of cardiovascular diseases signify a major incidence and developmental risk of this pathology. One of the processes accountable for this pathologic development is the instauration of dysbiosis and its connection with an inflammatory process. Low antioxidant colonic protection encourages the progression of inflammation, with cardiovascular dysfunctions being a secondary consequence of the dysbiosis. Read More

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https://www.mdpi.com/1999-4923/11/4/191
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http://dx.doi.org/10.3390/pharmaceutics11040191DOI Listing
April 2019
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Beyond PD-L1 Markers for Lung Cancer Immunotherapy.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-090 Lublin, Poland.

Immunotherapy using immune checkpoints inhibitors has become the standard treatment for first and second line therapy in patients with non-small cell lung cancer (NSCLC). However, proper predictive factors allowing precise qualification of NSCLC patients for immunotherapy have not been developed so far. Expression of PD-L1 on tumor cells and tumor mutation burden are used in qualification of patients to first line therapy with pembrolizumab and atezolizumab in combination with ipilimumab in prospective clinical trials. Read More

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https://www.mdpi.com/1422-0067/20/8/1915
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http://dx.doi.org/10.3390/ijms20081915DOI Listing
April 2019
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Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation.

Nutrients 2019 Apr 18;11(4). Epub 2019 Apr 18.

Centre for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.

Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common among the elderly. Read More

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http://dx.doi.org/10.3390/nu11040872DOI Listing

Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Pediatrics, Division of Neonatology, University of Oklahoma Health Sciences Center, 1200 North Everett Drive, ETNP7504, Oklahoma City, OK 73104, USA.

Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of these related diseases is currently incomplete, each of these conditions is thought to involve a dysfunctional, or overstated, host immunological response to both bacteria and dietary antigens, resulting in unchecked intestinal inflammation and, often, alterations in the intestinal microbiome. This inflammation can result in an impaired intestinal barrier allowing for bacterial translocation, potentially resulting in systemic inflammation and, in severe cases, sepsis. Read More

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https://www.mdpi.com/1422-0067/20/8/1912
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http://dx.doi.org/10.3390/ijms20081912DOI Listing
April 2019
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Regulatory Mechanism of The Induction of Regulatory T Cells through Growth Factors Released by Human Mesenchymal Stem Cells.

Crit Rev Immunol 2018 ;38(6):471-478

The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyusyu, Japan.

Mesenchymal stem cells (MSCs) undergo self-renewal and differentiation into multiple lineages. They exert anti-inflammatory and immunomodulatory effects via either cell-cell contact or via the production of soluble factors. Various anti-inflammatory and immunomodulatory mechanisms have been identified using experimental murine MSCs. Read More

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http://dx.doi.org/10.1615/CritRevImmunol.2018027821DOI Listing
January 2018

Evidence for antinociceptive effects of combined administration of vitamin E and celecoxib in tail-flick and formalin test in male rats.

Pharmacol Rep 2019 Feb 12;71(3):457-464. Epub 2019 Feb 12.

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.

Background: The aim of this study was to evaluate the effect of vitamin E co-administration with celecoxib in thermal and inflammatory pain in two model of pain assessment including thermal tail flick test of acute pain and formalin induced inflammatory model in adult male rats.

Methods: Seventy two male Wistar rats were divided into a vehicle received intraperitoneally olive oil, indomethacin (20 mg/kg), vitamin E (100, 200 and 400 mg/kg), celecoxib (3, 10, 30 and 60 mg/kg) groups, and combination groups received the combination of vitamin E (100 and 200 mg/kg) and celecoxib (3, 10 and 30 mg/kg). All drugs were dissolved in olive oil. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.02.005DOI Listing
February 2019

Hippocampal BDNF signaling is required for the antidepressant effects of perillaldehyde.

Pharmacol Rep 2019 Jan 16;71(3):430-437. Epub 2019 Jan 16.

Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi Province, PR China. Electronic address:

Background: Perillaldehyde is one of the main components in perilla. Previous studies have shown that perillaldehyde exerted an antidepressant effect in mice, some of which is mediated through regulation of the anti-inflammatory system and the monoamine system. The primary objective of this study was to investigate the possible effects of perillaldehyde on the neurotrophic system and to elucidate whether its antidepressant effect requires brain-derived neurotrophic factor (BDNF) signaling. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.009DOI Listing
January 2019

6-Methoxyflavonols from the aerial parts of Tetragonia tetragonoides (Pall.) Kuntze and their anti-inflammatory activity.

Bioorg Chem 2019 Apr 11;88:102922. Epub 2019 Apr 11.

Graduate School of Biotechnology and Department of Oriental Medicinal Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea. Electronic address:

Dried aerial parts of Tetragonia tetragonoides were extracted with 70% EtOH, and the evaporated residue was successively separated into EtOAc, n-BuOH, and HO fractions. As a result of repeated SiO, ODS, and Sephadex LH-20 column chromatography, four new 6-methoxyflavonol glycosides (2-4, 8) along with four known ones (1, 5-7) were isolated. Several spectroscopic data led to determination of chemical structures for four new 6-methoxyflavonol glycosides (2-4, 8) and four known ones, 6-methoxykaempferol 3-O-β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosyl-7-O-(6‴'-(E)-caffeoyl)-β-d-glucopyranoside (1), 6-methoxyquercetin (5), 6-methoxykaempferol (6), and 6-methoxykaempferol 7-O-β-d-glucopyranoside (7). Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102922DOI Listing

Doxycycline alleviates paraquat-induced acute lung injury by inhibiting neutrophil-derived matrix metalloproteinase 9.

Int Immunopharmacol 2019 Apr 16;72:243-251. Epub 2019 Apr 16.

Department of Emergency, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Paraquat (PQ), a highly toxic herbicide, selectively accumulates in the lungs and causes pulmonary damage through oxidative and inflammatory processes after intentional or accidental poisoning. The resulting acute lung injury (ALI) is characterized by neutrophil infiltration and extensive inflammation with rapid respiratory failure. However, effective therapies are lacking. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.015DOI Listing
April 2019
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Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages.

Eur J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India. Electronic address:

A series of aryl 7-chloroquinolinyl hydrazone derivatives (3a-u) have been synthesized in 55-76% yield using simple reaction condition. The synthesized compounds were evaluated for their anti-inflammatory activities based on their ability to inhibit pro-inflammatory cytokine secretion from the macrophages after stimulation with lipopolysaccharide (LPS). Three compounds appeared as promising anti-inflammatory agents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09280987193015
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http://dx.doi.org/10.1016/j.ejps.2019.04.016DOI Listing
April 2019
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Baicalin tetrazole acts as anti-pneumocystis carinii pneumonia candidate in immunosuppressed rat model.

Microb Pathog 2019 Apr 16. Epub 2019 Apr 16.

Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. Electronic address:

The present study was aimed to synthesize and evaluate tetrazoles of baicalin against Pneumocystis carinii pneumonia in the rat model. Among the seven synthesized baicalin tetrazoles, one with trifloromethyl group in the aromatic ring was found to be most potent during the initial study. The mechanism of preventive effect of most potent compound 4c against Pneumocystis carinii pneumonia was investigated in detail. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.027DOI Listing

Effect of symbiotic supplemented diet on innate-adaptive immune response, cytokine gene regulation and antioxidant property in Labeo rohita against Aeromonas hydrophila.

Fish Shellfish Immunol 2019 Apr 16. Epub 2019 Apr 16.

Department of Herbal and Environmental Science, Tamil University, Thanjavur, 613 005, Tamil Nadu, India.

Administration of probiotic, prebiotic or symbiotic supplemented diets boosts the antioxidant property, pro and/or anti-inflammatory cytokine gene transcription, innate-adaptive immunity, growth rate and feed digestibility with very low or no mortality in healthy and infected (both groups) in Labeo rohita against Aeromonas hydrophila is reported. The probiotic diet increased the white blood cell (WBC) count and globulin (GB) level significantly on or after 6th week whereas with the symbiotic diet the increase was noted two weeks earlier in both groups; the total protein (TP) level also increased significantly when fed with probiotic diet on weeks 6 and 8, whereas with symbiotic diet the significant increase manifested earlier at 4th week itself. The serum phagocytic activity (PA), respiratory burst activity (RBA), complement C3 (CC3) level, alternative complement pathway (ACP), lysozyme activity (LA), and immunoglobulin M (IgM) levels in head kidney (HK) leucocytes increased significantly (P < 0. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.036DOI Listing

Anti-inflammatory effects of vanadium-binding protein from Halocynthia roretzi in LPS-stimulated RAW264.7 macrophages through NF-κB and MAPK pathways.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Department of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea; Skin Biotechnology Center, Kyung Hee University, Suwon 16229, Republic of Korea. Electronic address:

Vanadium-binding protein (VBP) was separated from the blood of the fresh sea urchin Halocynthia roretzi through (NH)SO precipitation, Diethylaminoethyl Sepharose fast-flow ion-exchange chromatography, and Sephacryl S-200 high-resolution size-exclusion chromatography. The protein size and purification yield of VBP were 27 kDa and 5.5%, respectively. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.106DOI Listing

Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 16. Epub 2019 Apr 16.

Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China. Electronic address:

Exaggerated endothelial pro-inflammatory response is a hallmark in the early stage of sepsis and contributes to the subsequent tissue injury and organ failure. The anti-inflammatory effects of AMP-activated protein kinase (AMPK) activator metformin in sepsis has been revealed. However, the underlying mechanisms remain not fully understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193012
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http://dx.doi.org/10.1016/j.bbadis.2019.04.009DOI Listing
April 2019
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Long-term administration of Aspalathus linearis infusion affects spatial memory of adult Sprague-Dawley male rats as well as increases their striatal dopamine content.

J Ethnopharmacol 2019 Apr 16:111881. Epub 2019 Apr 16.

Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Centre for Preclinical Research and Technology CePT, Banacha 1b, 02-097, Warsaw, Poland. Electronic address:

Ethnopharmacological Relevance: Everyday use of the herbal tea rooibos, produced from Aspalathus linearis (Brum.f) Dahlg. (Fabaceae) is customary in South Africa, a continuation of its historical use by indigenous people. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111881DOI Listing

Morin post-treatment confers neuroprotection in a novel rat model of mild repetitive traumatic brain injury by targeting dementia markers, APOE, autophagy and Wnt/β-catenin signaling pathway.

Brain Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology & Toxicology, Cairo University, Cairo, Egypt. Electronic address:

Exposure to repetitive brain trauma has gained attention for its similarity to sport-related trauma. The traumatic brain injury (TBI) is strongly associated with neurodegenerative pathology that affects cognition, memory and behavior. The current study developed a novel mild repetitive traumatic brain injury (mRTBI) model to highlight some of the possible molecular pathological mechanisms compared to those of single trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193018
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http://dx.doi.org/10.1016/j.brainres.2019.04.003DOI Listing
April 2019
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Does insurance coverage affect use of tests and treatments for working age individuals with carpal tunnel syndrome in the United States? Analysis of the National Ambulatory Medical Care Survey (2005-2014).

Arch Phys Med Rehabil 2019 Apr 16. Epub 2019 Apr 16.

University of Pittsburgh, School of Health and Rehabilitation Science, Department of Physical Therapy.

Objective: Carpal tunnel syndrome (CTS) is frequently seen as a work-related disorder. Few studies have examined the treatment of CTS by insurance coverage, and none have used a large, population-based data set. This study examined the extent to which the use of CTS tests/treatments varied for those on worker's compensation (WCI) versus private insurance and Medicaid, controlling for patient and provider characteristics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039993193024
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http://dx.doi.org/10.1016/j.apmr.2019.03.014DOI Listing
April 2019
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Ginsenoside Rg1 attenuates hepatic insulin resistance induced by high-fat and high-sugar by inhibiting inflammation.

Eur J Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Biology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan, 650500, PR China; Yunnan Province Key Laboratory for Nutrition and Food Safety in Universities, PR China. Electronic address:

Ginsenoside Rg1 is the active ingredient of Chinese herbal medicine ginseng and sanqi, which has remarkable effects on anti-inflammation and anti-diabetes. In this study, we explored the molecular mechanism of ginsenoside Rg1 against diabetes in rat subjected to insulin resistance induced by high-fat and high-sugar (HFHS). Biochemical analysis revealed that ginsenoside Rg1 significantly decreased the serum levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, total cholesterol, triglyceride, low-density lipoprotein and increased the serum levels of high-density lipoprotein, which indicated ginsenoside Rg1 improved the extent of hepatic steatosis. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.027DOI Listing

Intermittent hypoxia impairs uterine artery function in pregnant mice.

J Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Key Points: Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease. Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1113/JP277775
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http://dx.doi.org/10.1113/JP277775DOI Listing
April 2019
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Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease.

PLoS One 2019 19;14(4):e0215033. Epub 2019 Apr 19.

Computational Biology, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.

Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH). EETs have pleiotropic effects, including anti-inflammatory activity. Using a Connectivity Map (CMAP) approach, we identified an inverse-correlation between an exemplar EPHX2 inhibitor (EPHX2i) compound response and an inflammatory bowel disease patient-derived signature. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215033PLOS
April 2019
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Oral shea nut oil triterpene concentrate supplement ameliorates pain and histological assessment of articular cartilage deterioration in an ACLT injured rat knee osteoarthritis model.

PLoS One 2019 19;14(4):e0215812. Epub 2019 Apr 19.

Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan.

Osteoarthritis (OA) is a multifactorial joint disease and a common disabling condition in the elderly population. The associated pain and pathohistological changes in cartilage are common features of OA in both humans and animal models. Shea nut oil extract (SheaFlex75) contains a high triterpenoid concentration and has demonstrated anti-inflammatory and antiarthritic effects in both human and animal studies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215812PLOS
April 2019
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In vitro chondroprotective potential of Senna alata and Senna tora in porcine cartilage explants and their species differentiation by DNA barcoding-high resolution melting (Bar-HRM) analysis.

PLoS One 2019 19;14(4):e0215664. Epub 2019 Apr 19.

Excellent Center in Veterinary Bioscience, Chiang Mai University, Chiang Mai, Thailand.

Senna species and anthraquinone derivatives generated by these organisms, rhein and aloe-emodin, exert anti-inflammatory effects. These species present a similar morphology but produce different ingredients when they are used as medicinal products. In this study, a DNA barcoding- (Bar-) high-resolution melting (HRM) technique was developed using internal transcribed sequence 2 (ITS2) to differentiate between Senna alata and Senna tora as a result of significant differences in their melting profiles. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215664PLOS
April 2019
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Assessing the Bioavailability of Zinc and Indole Compounds from Mycelial Cultures of the Bay Mushroom Imleria badia (Agaricomycetes) Using In Vitro Models.

Int J Med Mushrooms 2019 ;21(4):343-352

Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland.

Zinc and indole compounds demonstrate anti-inflammatory, antidepressant, and antioxidant activity. Edible mushrooms are good sources of these substances. Therefore, in this study, we aimed to study the accumulation, release, and absorption of zinc and indole compounds from mycelial cultures of Imleria badia species using in vitro models. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030328DOI Listing
January 2019
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GdX/UBL4A-knockout mice resist collagen-induced arthritis by balancing the population of T1/T17 and regulatory T cells.

FASEB J 2019 Apr 19:fj201802217RR. Epub 2019 Apr 19.

State Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing, China.

Rheumatoid arthritis (RA) is an autoimmune disease associated with synovial hyperplasia and bone and cartilage destruction. T cells, notably T helper (T)-1 and T17 cells, play a critical role in the pathologic process of RA. However, it remains unclear how T1 and T17 cells are regulated during RA. Read More

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http://dx.doi.org/10.1096/fj.201802217RRDOI Listing

Newly defined ABCB5 dermal mesenchymal stem cells promote healing of chronic iron overload wounds via secretion of interleukin-1 receptor antagonist.

Stem Cells 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

Here we report the beneficial effects of a newly identified dermal cell subpopulation expressing the ATP-binding cassette subfamily B member 5 (ABCB5) for the therapy of non-healing wounds. Local administration of dermal ABCB5 -derived MSCs attenuated macrophage-dominated inflammation and thereby accelerated healing of full-thickness excisional wounds in the iron overload mouse model mimicking the non-healing state of human venous leg ulcers. The observed beneficial effects were due to interleukin-1 receptor antagonist (IL-1RA) secreted by ABCB5 -derived MSCs, which dampened inflammation and shifted the prevalence of unrestrained pro-inflammatory M1 macrophages toward repair promoting anti-inflammatory M2 macrophages at the wound site. Read More

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http://dx.doi.org/10.1002/stem.3022DOI Listing
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