677,067 results match your criteria Anti-inflammatory & anti-allergy agents in medicinal chemistry[Journal]


Dexamethasone suppresses radicular pain through targeting L-PGDS/PI3K/Akt pathway in rats with lumbar disc herniation.

Pain Pract 2020 Jul 8. Epub 2020 Jul 8.

Department of Orthopaedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.

The Purpose: Lumbar disc herniation (LDH) is a frequently occurring disease with unknown etiology, which makes treatment a challenge. The aim of this study was to analyze the effects of dexamethasone on LDH and elucidate the underlying mechanisms.

General Methods: LDH rat model was established by nucleus pulposus (NP) implantation. Read More

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http://dx.doi.org/10.1111/papr.12934DOI Listing

Crocin: A fighter against inflammation and pain.

Food Chem Toxicol 2020 Jul 5:111521. Epub 2020 Jul 5.

Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Crocin, a water-soluble carotenoid, is known as a pharmacologically active compound, particularly for its potent anti-oxidant activity. The present work provides a comprehensive review of the available literature concerning the anti-inflammatory properties of crocin in various organs/systems as well as its anti-nociceptive effects. PubMed, Scopus, and Web of Science electronic databases were systematically searched up to 28 March 2020 to detect all relevant preclinical and human studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111521DOI Listing

Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways.

Food Chem Toxicol 2020 Jul 5:111570. Epub 2020 Jul 5.

Department of Medical Biology, Faculty of Medicine, Nigde Omer Halisdemir University, Nidge Campus, 51240 Turkey.

Nerium oleander, a member of family Apocynaceae, is commonly known as Kaner in various countries of Asia and Mediterranean region. This plant has been renowned to possess significant therapeutic potential due to its various bioactive compounds which have been isolated from this plant e.g. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111570DOI Listing

Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss.

Food Chem Toxicol 2020 Jul 5:111555. Epub 2020 Jul 5.

Fondazione Policlinico Universitario A, Gemelli IRCCS, Roma, Italia; Department of Head and Neck Surgery, Università Cattolica del Sacro Cuore, Roma, Italia. Electronic address:

Scope: The imbalance of cellular redox status, in conjunction with the activation of inflammatory processes, have been considered common predominant mechanisms of noise-induced hearing loss. The identification of novel natural products as potential therapeutics, targeting oxidative stress and inflammatory pathways, is an emerging field. Here, we focused on the polyphenol caffeic acid (CA), the major representative of hydroxycinnamic acids and phenolic acid, in order to investigate its protective capacity in a model of sensorineural hearing loss induced by noise. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111555DOI Listing

Cyclooxygenases and the cardiovascular system.

Pharmacol Ther 2020 Jul 5:107624. Epub 2020 Jul 5.

Blizard Institute, Barts and The London School of Medicine and Dentistry, The Blizard Building, 4 Newark Street, London E1 2AT, United Kingdom.

Cyclooxygenase (COX)-1 and COX-2 are centrally important enzymes within the cardiovascular system with a range of diverse, sometimes opposing, functions. Through the production of thromboxane, COX in platelets is a pro-thrombotic enzyme. By contrast, through the production of prostacyclin, COX in endothelial cells is antithrombotic and in the kidney regulates renal function and blood pressure. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2020.107624DOI Listing

Baseline Frequency of Inflammatory Cxcl9-Expressing Tumor-Associated Macrophages Predicts Response to Avelumab Treatment.

Cell Rep 2020 Jul;32(1):107873

Cancer Immunology Discovery, Pfizer, Inc., 10777 Science Center Drive, San Diego, CA 92021, USA. Electronic address:

The tumor microenvironment is rich with immune-suppressive macrophages that are associated with cancer progression and resistance to immune checkpoint therapy. Using pre-treatment tumor biopsies complemented with single-cell RNA sequencing (RNA-seq), we characterize intratumoral immune heterogeneity to unveil potential mechanisms of resistance to avelumab (anti-PD-L1). We identify a proinflammatory F480MHCIILy6C macrophage population that is associated with response rather than resistance to avelumab. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107873DOI Listing

GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.

Cell Rep 2020 Jul;32(1):107857

Molecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK; Wellcome Sanger Institute, Hinxton, UK; NIHR Cambridge Biomedical Research Centre, Cambridge, UK. Electronic address:

Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis. We find that GM-CSF drives the maturation and polarization of inflammatory intestinal macrophages, promoting anti-microbial functions while suppressing wound-healing transcriptional programs. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107857DOI Listing

The Possible Protective Effect of Colchicine against Liver Damage Induced by Renal Ischemia-Reperfusion Injury: Role of Nrf2 and NLRP3 inflammasome.

Can J Physiol Pharmacol 2020 Jul 8. Epub 2020 Jul 8.

Al-Azhar University, 68820, pharmacology and toxicology , nasr city-cairo , Cairo, Egypt ;

Background: Ischemia/reperfusion injury (IRI) induces an inflammatory response and production of ROS, which affects the organs remote to the sites of RIR. However, remote effects of RIR injury on the liver need further investigations. Renal injury associated with liver disease is a common clinical problem. Read More

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http://dx.doi.org/10.1139/cjpp-2020-0230DOI Listing

Autoimmune Conditions: Ankylosing Spondylitis.

FP Essent 2020 07;494:30-35

St. Luke's Family Medicine Residency, 2830 Easton Ave, Bethlehem, PA 18017.

Ankylosing spondylitis (AS) is a rare yet significant cause of back pain in young adults that often is overlooked. AS should be suspected if symptoms of inflammatory back pain are present or if the patient has a personal or family history of related conditions. X-rays are the initial imaging modality of choice. Read More

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Syringic acid modulates molecular marker-involved cell proliferation, survival, apoptosis, inflammation, and angiogenesis in DMBA-induced oral squamous cell carcinoma in Syrian hamsters.

J Biochem Mol Toxicol 2020 Jul 8:e22574. Epub 2020 Jul 8.

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, India.

Despite, different medicinal phyto compounds giving an inexhaustible variety of anticancer drugs, potent signalling mechanism of leads  the key successes of anticancer agent, anti-inflammatory, induction of apoptosis, and antiangiogenic. The current study was conducted to estimate the effect of syringic acid (SA) on tumor necrosis factor-α (TNF-α)-mediated nuclear factor-κB (NF-κB) signaling pathways, inducing apoptosis and angiogenic signaling pathways in a hamster model by preneoplastic stages, histological, immunohistochemistry and immunoblots analysis. Hamsters were given oral cancer by painting 0. Read More

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http://dx.doi.org/10.1002/jbt.22574DOI Listing

Vedolizumab Trough Levels in Children with Anti-TNF Refractory Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

Objectives: Inflammatory bowel disease (IBD) can be successfully treated with vedolizumab. Studies in adult IBD patients have shown that differences in response to vedolizumab may be related to variability in vedolizumab trough levels, but in children with pediatric-onset IBD data regarding vedolizumab trough levels are not available. Thus far, the role of trough levels in pediatric-onset IBD treatment remains unclear. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002833DOI Listing

DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway.

Clin Sci (Lond) 2020 Jul 8. Epub 2020 Jul 8.

Anhui medical university, Hefei, China.

The regulation of macrophages during inflammatory responses is a crucial process in alcoholic liver disease (ALD) and aberrant macrophage DNA methylation is associated with inflammation. Our preliminary screening results of macrophage methylation in this study demonstrated the zinc finger SWI2/SNF2 and MuDR (SWIM) - domain containing 3 (ZSWIM3) were hypermethylated in the 5ꞌ untranslated region (5ꞌ-UTR) region. ZSWIM3, a novel zinc finger-chelate domain of SWIM, is predicted to function in DNA-binding and protein-binding interactions. Read More

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http://dx.doi.org/10.1042/CS20200031DOI Listing
July 2020
5.598 Impact Factor

Involvement of redox status and the nuclear-related factor 2 in protecting against cadmium-induced renal injury with Sana Makki (Cassia senna L.) pre-treatment in male rats.

An Acad Bras Cienc 2020 6;92(2):e20191237. Epub 2020 Jul 6.

Department of Botany and Microbiology, King Saud University, Saudi Arabia.

This study was designed to investigate the potential defensive strategy of Sana Makki extract (SME) against Cd-induced in vivo nephrotoxicity and its underlying mechanisms. Male albino rats were used in a thirty days study comparing control, SME-treated, CdCl2-treated, and combined SME and Cd treatment. Pre-treatment with SME significantly reduced serum kidney biomarkers (urea and creatinine), the concentration of renal KIM-1, and kidney index values. Read More

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http://dx.doi.org/10.1590/0001-3765202020191237DOI Listing

Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride.

Acta Cir Bras 2020 Jul 3;35(5):e202000507. Epub 2020 Jul 3.

PhD, Associate Professor, Department of Pharmaceutical Science, UEPG, Ponta Grossa-PR, Brazil. Design of the study, technical procedures, interpretation of data, manuscript writing, critical revision, final approval.

Purpose: To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions.

Methods: The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Read More

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http://dx.doi.org/10.1590/s0102-865020200050000007DOI Listing

The exogenous natural phospholipids, EPA-PC and EPA-PE, contribute to ameliorate inflammation and promote macrophage polarization.

Food Funct 2020 Jul 8. Epub 2020 Jul 8.

College of Food Science and Engineering, Ocean University of China, Qingdao, China.

Dietary intake of sea cucumber phospholipids, a rich source of eicosapentaenoic acid in the form of phospholipids (EPA-PLs), has been shown to improve obesity and related disorders. However, whether dietary eicosapentaenoic acid in the form of phosphatidylcholine and phosphatidylethanolamine (EPA-PC and EPA-PE, respectively) shows anti-inflammatory efficacy and its underlying mechanism has scarcely been investigated to date. Thus, the purpose of this study was to determine if EPA-PC and EPA-PE improve chronic inflammation and alter the interaction between macrophages and adipocytes. Read More

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http://dx.doi.org/10.1039/d0fo00804dDOI Listing

The effect of willow fodder feeding on immune cell populations in the blood and milk of late-lactating dairy goats.

Animal 2020 Jun 23:1-12. Epub 2020 Jun 23.

Department of Natural Resources, Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, 68 Hamakabim Rd, Rishon Le Ziyyon, 7505101, Israel.

In a previous study, we showed that access to willow fodder decreased somatic cell counts (SCC) in the milk of local Mamber goats grazing in brushland at the end of lactation. To test whether the consumption of willow affects the cells of the immune system, Alpine crossbred dairy goats grazing in the same environment were either offered free access to freshly cut willow fodder (W, n = 24) or not (C, n = 24) for 2 weeks. The willow fodder contained 7. Read More

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http://dx.doi.org/10.1017/S1751731120001494DOI Listing

Hyperbaric Oxygen Therapy and Vascular Complications in Diabetes Mellitus.

Angiology 2020 Jul 8:3319720936925. Epub 2020 Jul 8.

Department of Radiobiology and Molecular Genetics, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Vascular complications in patients with diabetes mellitus (DM) are common. Since impaired oxygen balance in plasma plays an important role in the pathogenesis of chronic DM-associated complications, the administration of hyperbaric oxygen therapy (HBOT) has been recommended to influence development of vascular complications. Hyperbaric oxygen therapy involves inhalation of 100% oxygen under elevated pressure from 1. Read More

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http://dx.doi.org/10.1177/0003319720936925DOI Listing

The role of the non-neuronal cholinergic system in inflammation and degradation processes in osteoarthritis.

Arthritis Rheumatol 2020 Jul 8. Epub 2020 Jul 8.

Sorbonne Université, Paris, France.

Objectives: The non-neuronal cholinergic system represents non-neuronal cells that have the biochemical machinery to synthetize de novo and/or respond to acetylcholine (ACh). We investigated this biochemical machinery in chondrocytes and its involvement in osteoarthritis (OA).

Methods: Expression of the biochemical machinery for ACh metabolism and nicotinic ACh receptors (nAChR), particularly α7nAChR, in human OA and murine chondrocytes was determined by PCR and ligand-binding. Read More

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http://dx.doi.org/10.1002/art.41429DOI Listing

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview.

Obes Rev 2020 Jul 7. Epub 2020 Jul 7.

Faculty of Health Sciences, Department of Experimental Immunology, Medical University of Lodz, Lodz, Poland.

Adipokines are predominantly known to play a vital role in the control of food intake, energy homeostasis and regulation of glucose and lipid metabolism. However, evidence supporting the concept of their extensive involvement in immune system defence mechanisms and inflammatory processes continues to grow. Some of the adipokines, that is, leptin and resistin, have been recognized to exhibit mainly pro-inflammatory properties, whereas others such as visfatin, chemerin, apelin and vaspin have been found to exert regulatory effects. Read More

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http://dx.doi.org/10.1111/obr.13055DOI Listing

The molecular mechanisms of probiotic strains in improving aging bone and muscle of D-galactose-induced aging rats.

J Appl Microbiol 2020 Jul 7. Epub 2020 Jul 7.

School of Industrial Technology, Universiti Sains Malaysia, 11800, Penang, Malaysia.

Aim: The aim of this study was to evaluate the molecular mechanisms of Lactobacillus strains in improving aging of the musculoskeletal system.

Methods And Results: The anti-aging mechanism of three probiotics strains Lactobacillus fermentum DR9, L. paracasei OFS 0291 and L. Read More

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http://dx.doi.org/10.1111/jam.14776DOI Listing

Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double-blind placebo-controlled trial.

Phytother Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Migraine is the most common type of primary headaches. Increased levels of interleukin-6 (IL-6), calcitonin-gene-related peptide (CGRP) and nitric oxide (NO) lead to inflammation and neurogenic pain. Cinnamon has anti-inflammatory and neuroprotective properties. Read More

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http://dx.doi.org/10.1002/ptr.6721DOI Listing

Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment.

Aging Clin Exp Res 2020 Jul 7. Epub 2020 Jul 7.

Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90100, Palermo, Italy.

Osteoarthritis (OA) is the most prevalent musculoskeletal disease and a major cause of negative relevant outcomes, associated with an ever-increasing societal burden. Pharmaceutical-grade chondroitin sulfate (CS) was repeatedly reported to reduce pain and improve function in patients with OA. This article aims to review the evidence for the role of highly purified (hp) CS (Condrosulf, IBSA) in the treatment of OA. Read More

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http://dx.doi.org/10.1007/s40520-020-01643-8DOI Listing

IL-34, IL-36 and IL-38 in colorectal cancer-key immunoregulators of carcinogenesis.

Biophys Rev 2020 Jul 7. Epub 2020 Jul 7.

Discipline of Pathology, School of Medical Sciences and Bosch Institute, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.

Colorectal cancer (CRC) is still a big killer nowadays, but the precise underlying mechanism remains to be explored. It is believed that imbalance of host immunity in the local microenvironment plays a critical role in the tumorigenesis of CRC. IL-34 is inversely correlated with overall survival in CRC patients, perhaps via regulating terminal differentiation of a subset of macrophages (M2). Read More

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http://dx.doi.org/10.1007/s12551-020-00726-0DOI Listing

Anti-inflammatory canthin-6-one alkaloids from the roots of Thailand Eurycoma longifolia Jack.

J Nat Med 2020 Jul 8. Epub 2020 Jul 8.

Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China.

Two new canthin-6-one alkaloids, 4,9-dimethoxy-5-hydroxycanthin-6-one (1) and 9-methoxy-(R/S)-5-(1-hydroxyethyl)-canthin-6-one (2), together with fifteen known ones were isolated from the roots of Thailand Eurycoma longifolia Jack. Among the known canthin-6-one alkaloids, compounds 9 and 16 were isolated from the Eurycoma genus for the first time. Meanwhile, the nitric oxide (NO) inhibitory activities of all isolates were examined in lipopolysaccharide (LPS)-stimulated RAW264. Read More

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http://dx.doi.org/10.1007/s11418-020-01433-6DOI Listing

Neuroprotective Activities of Long-Acting Granulocyte-Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice.

Neurotherapeutics 2020 Jul 7. Epub 2020 Jul 7.

Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Loss of dopaminergic neurons along the nigrostriatal axis, neuroinflammation, and peripheral immune dysfunction are the pathobiological hallmarks of Parkinson's disease (PD). Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been successfully tested for PD treatment. GM-CSF is a known immune modulator that induces regulatory T cells (Tregs) and serves as a neuronal protectant in a broad range of neurodegenerative diseases. Read More

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http://dx.doi.org/10.1007/s13311-020-00877-8DOI Listing

Evaluating antitumor activity of antiglypican-3 therapy in experimentally induced skin cancer in mice.

Arch Dermatol Res 2020 Jul 7. Epub 2020 Jul 7.

Dept. of Internal Medicine (Dermatology), Faculty of Medicine, University of Tabuk, Tabuk, 71471, Saudi Arabia.

Glypican-3 (GPC3) is considered as a cell surface heparan sulfate proteoglycan. It is overexpressed in skin cancer and promotes tumor progression and pathogenicity. Therefore, we aimed to find out the therapeutic effects of immuno-suppressing GPC3 in skin cancer experimentally induced in mice as well as to underline molecular mechanisms especially inflammatory and apoptotic pathways. Read More

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http://dx.doi.org/10.1007/s00403-020-02102-0DOI Listing

The impact of the duration of HAART on cytokine profiles in pregnancy.

Inflamm Res 2020 Jul 7. Epub 2020 Jul 7.

Women's Health and HIV Research Unit, Discipline of Obstetrics and Gynaecology, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Objective: To determine the cytokine profile of HIV infected women treated with highly active anti-retroviral therapy (HAART) of variable duration in pregnancy.

Methods: HIV infected women were enrolled at a large tertiary hospital in Durban, South Africa in their antenatal period and stratified into those that initiated HAART before pregnancy (pre-pregnancy HAART or PPH group) and those who initiated HAART during pregnancy (in-pregnancy HAART or IPH group). These were compared with HIV negative women (HN group), matched for gestational age at the time of enrolment. Read More

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http://dx.doi.org/10.1007/s00011-020-01375-5DOI Listing

Health benefits of xylitol.

Appl Microbiol Biotechnol 2020 Jul 7. Epub 2020 Jul 7.

Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.

Many diseases, including caries, chronic inflammatory diseases, diabetes, and obesity, are associated with uncontrolled sugar consumption. Artificial sweeteners are commonly used in food and pharmaceutical industries as sugar substitutes for the prevention of several dental and body diseases; they also have a favorable impact on body weight as they may help to restrict simple sugar consumption. Xylitol is a sugar alcohol that is commonly used as a sweetener. Read More

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http://dx.doi.org/10.1007/s00253-020-10708-7DOI Listing

Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells.

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 8. Epub 2020 Jul 8.

Department of Respiratory and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.

Isoliquiritigenin (ISL), a natural flavonoid derived from the root of liquorice, has been reported to possess anti-inflammatory and antioxidant activities. Previous studies have found that ISL plays a crucial role in anti-fibrosis of adipose tissue and renal tissue; however, its effect on pulmonary fibrogenesis has not been demonstrated. In this study, we aimed to explore the roles and the underlying mechanisms of ISL in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells. Read More

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http://dx.doi.org/10.1093/abbs/gmaa067DOI Listing

Mixed Connective Tissue Disease With Retroperitoneal Fibrosis: A Rare Occurrence.

Arch Rheumatol 2020 Mar 6;35(1):137-141. Epub 2019 Nov 6.

Department of Rheumatology, Kalinga Institute of Medical Sciences, Bhubaneswar, India.

Mixed connective tissue disease (MCTD) is an autoimmune condition characterized by mixed clinical features of connective tissue diseases like systemic lupus erythematosus, polymyositis or systemic sclerosis with high titers of anti-U1 small nuclear ribonucleoprotein. Interstitial lung disease is a frequent manifestation of MCTD. Retroperitoneal fibrosis (RPF) is a rare fibro-inflammatory process involving the retroperitoneum. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322295PMC

Coexistence of Juvenile Systemic Lupus Erythematosus and Juvenile Spondyloarthropathy: A Case Report and Review of the Literature.

Arch Rheumatol 2020 Mar 8;35(1):132-136. Epub 2020 Jan 8.

Department of Pediatric Rheumatology, University of Health Science, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.

Sacroiliitis has been scarcely reported in patients with systemic lupus erythematosus (SLE). In this article, we presented a pediatric case with coexis- tence of juvenile SLE and juvenile spondyloarthropathy (SpA) and discussed the clinical and laboratory findings by the literature review. A 16-year- old female patient with a diagnosis of SLE was referred to our outpatient clinic with inflammatory low-back pain for two months. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322298PMC

Blau Syndrome and Early-Onset Sarcoidosis: A Six Case Series and Review of the Literature.

Arch Rheumatol 2020 Mar 6;35(1):117-127. Epub 2019 Nov 6.

Division of Pediatric Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Objectives: This study aims to discuss the clinical, laboratory and genetic findings, and treatment options for six patients who were diagnosed with Blau syndrome (BS)/early-onset sarcoidosis (EOS).

Patients And Methods: The study included four patients (2 males,2 females; mean age 7 years; range 4 to 10 years) with EOS and two siblings (1 male, 1 female; mean age 10 years; range, 9 to 11 years) with BS. Age, age of initial symptoms, age of diagnosis; articular involvement, presence of uveitis, dermatitis, or fever, other organ involvement, laboratory findings, results of metabolic tests for mucopolysaccharidosis and mucolipidosis, results of genetic, pathologic, and immunologic tests, radiologic findings to evaluate skeletal dysplasia, and treatment options were collected. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322314PMC

Screening for Latent Tuberculosis in Children With Immune-mediated Inflammatory Diseases Treated With Anti-tumor Necrosis Factor Therapy: Comparison of Tuberculin Skin and T-SPOT Tuberculosis Tests.

Arch Rheumatol 2020 Mar 25;35(1):20-28. Epub 2019 Jun 25.

Department of Pediatric Pulmonology, Istanbul University Cerrahpaşa Medical School, Istanbul, Turkey.

Objectives: This study aims to analyze the coherence between T-SPOT tuberculosis test (T-SPOT.TB) and tuberculin skin test (TST) with different cut-off values in screening latent tuberculosis infection (LTBI) both prior to and at the sixth month of anti-tumor necrosis factor (anti-TNF) treatment.

Patients And Methods: This prospective multicentric study included 57 children (34 girls, 23 boys, mean age 12. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322294PMC

Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects.

Turk J Surg 2020 Mar 18;36(1):96-104. Epub 2020 Mar 18.

Department of Medical Pharmacology, Ankara Yildirim Beyazit University School of Medicine, Ankara, Turkey.

Objectives: The aim of the present study was to investigate the effect of thymoquinone on ischemia/reperfusion (I/R) injury at 150 min or/and 24 h of reperfusion in male Wistar Rats.

Material And Methods: The therapeutic value of thymoquinone on cellular damage caused by reactive oxygene species or inflammatory processes during intestinal ischemia/reperfusion was investigated using pharmacological function studies on smooth muscle contractile responses of acetylcholine (Ach) and KCl, along with myeloperoxidase activity, malondialdehyhde, glutathione and cytokine levels such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β in serum and ileum tissue of rats. Thymoquinone was administered at a dose of 50 mg/kg orally for three times: 30 min, 24 h and 48 h prior to the surgical procedure. Read More

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http://dx.doi.org/10.5578/turkjsurg.4583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315442PMC

Protective effect of melatonin against methotrexate-induced testicular damage in the rat model: An experimental study.

Int J Reprod Biomed (Yazd) 2020 May 31;18(5):327-338. Epub 2020 May 31.

Research Institute for Human High Performance and Health Promotion (HHP & HP), Khon Kaen, Thailand.

Background: Methotrexate (MTX) has been shown to affect the testes adversely, especially the seminiferous epithelium. As melatonin, an endocrine hormone, has been shown to normalize testicular function, its ability to prevent MTX-induced testicular damage should be considered.

Objective: Based on the antioxidant, anti-inflammatory, and antiapoptotic activities of melatonin, this study aimed to investigate its protective effect against testicular damage induced by MTX. Read More

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http://dx.doi.org/10.18502/ijrm.v13i5.7153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306061PMC

Avenanthramides as lipoxygenase inhibitors.

Heliyon 2020 Jun 29;6(6):e04304. Epub 2020 Jun 29.

Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Avenanthramides (AVAs) present in oats are amides of anthranilic and cinnamic acids. AVAs are potent antioxidants and have anti-inflammatory properties. There are various potential mechanisms for their anti-inflammatory effects, including inhibition of lipoxygenases (LOX), which catalyse oxygenation of polyunsaturated fatty acids into potent signal molecules involved in inflammatory processes. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330496PMC

Antioxidant and anti-inflammatory properties of alkaloid leaf extract.

Heliyon 2020 Jun 28;6(6):e04141. Epub 2020 Jun 28.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Cyberjaya, 63000, Cyberjaya, Malaysia.

(. ) which belongs to Erythroxylaceae family is a tropical flowering plant from the genus of Erythroxylum. It is used in Malaysia and Thailand's traditional medicines, yet there is limited scientific reports on its medicinal value. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330067PMC

Sulfasalazine in dermatology: A lesser explored drug with broad therapeutic potential.

Int J Womens Dermatol 2020 Jun 13;6(3):191-198. Epub 2020 Feb 13.

Department of Dermatology, Venereology & Leprology, Maulana Azad Medical College, New Delhi, India.

Sulfasalazine is an aminosalicylate primarily used in the treatment of rheumatoid arthritis and ulcerative colitis. Its immunomodulatory, anti-inflammatory, and antiproliferative properties make it a potential therapeutic option for various dermatological disorders. Owing to its wide range of effects, it is often used off-label in dermatological diseases, such as alopecia areata, psoriasis and psoriatic arthritis, lichen planus, and pemphigus. Read More

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http://dx.doi.org/10.1016/j.ijwd.2020.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330441PMC

Impact of systemic steroid treatment on talc pleurodesis: a report of six cases.

J Pharm Health Care Sci 2020 3;6:15. Epub 2020 Jul 3.

Department of Pharmaceutical Services, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima-shi, Hiroshima, 734-8551 Japan.

Background: Instillation of sterile graded talc in the pleural space is performed to prevent reaccumulation of malignant pleural effusion after drainage. Talc is thought to encourage pleural adhesions as part of the repair process by provoking inflammation, suggesting that adhesions are less likely to form in patients taking corticosteroids or other drugs with anti-inflammatory effects. However, the relationship between steroid therapy and pleurodesis efficacy remains unclear. Read More

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http://dx.doi.org/10.1186/s40780-020-00171-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333338PMC

Whole-genome, transcriptome, and methylome analyses provide insights into the evolution of platycoside biosynthesis in , a medicinal plant.

Hortic Res 2020 1;7:112. Epub 2020 Jul 1.

Genomics Division, National Institute of Agricultural Sciences (NAS), Jeonju, 54874 Korea.

Triterpenoid saponins (TSs) are common plant defense phytochemicals with potential pharmaceutical properties. (Campanulaceae) has been traditionally used to treat bronchitis and asthma in East Asia. The oleanane-type TSs, platycosides, are a major component of the root extract. Read More

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http://dx.doi.org/10.1038/s41438-020-0329-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327020PMC

Machine learning approach to predict medication overuse in migraine patients.

Comput Struct Biotechnol J 2020 12;18:1487-1496. Epub 2020 Jun 12.

BioBIM (InterInstitutional Multidisciplinary Biobank), IRCCS San Raffaele Pisana, Via di Val Cannuta 247, 00166 Rome, Italy.

Machine learning (ML) is largely used to develop automatic predictors in migraine classification but automatic predictors for medication overuse (MO) in migraine are still in their infancy. Thus, to understand the benefits of ML in MO prediction, we explored an automated predictor to estimate MO risk in migraine. To achieve this objective, a study was designed to analyze the performance of a customized ML-based decision support system that combines support vector machines and Random Optimization (RO-MO). Read More

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http://dx.doi.org/10.1016/j.csbj.2020.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327028PMC

Anti-Inflammatory Activity and Mechanism of Hydrostatin-SN1 From in Interleukin-10 Knockout Mice.

Front Pharmacol 2020 19;11:930. Epub 2020 Jun 19.

School of Medicine, Shanghai University, Shanghai, China.

Biopeptides derived from marine species have garnered significant research interest owing to their anti-inflammatory, antibacterial, and anticancer activities. In our previous study, Hydrostatin-SN1, a bioactive peptide extracted from the venom gland T7 phage display library, demonstrated anti-inflammatory activity in a dextran sulfate sodium-induced murine colitis model. In this study, we investigated the anti-inflammatory activity and the underlying mechanism of Hydrostatin-SN1 in lipopolysaccharide (LPS)-induced bone marrow-derived macrophage (BMDM) cells and interleukin (IL)-10 knockout mice. Read More

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http://dx.doi.org/10.3389/fphar.2020.00930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318914PMC

Proteomics profiling asthma induced-lysine acetylation.

EXCLI J 2020 4;19:734-744. Epub 2020 Jun 4.

Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.

Asthma is a chronic inflammatory disease that has been extensively studied for many years. However, finding a complete cure remains a significant challenge. Protein acetylation, especially histone acetylation, plays a significant role in the anti-asthma process. Read More

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http://dx.doi.org/10.17179/excli2019-1508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332788PMC

Anti-inflammatory and Analgesic Effects of (Benth.).

Turk J Pharm Sci 2020 Jun 22;17(3):329-336. Epub 2020 Jun 22.

GITAM Institute of Pharmacy, Department of Pharmacognosy and Phytochemistry, Andhra Pradesh, India.

Objectives: The analgesic and anti-inflammatory effects of methanolic extract of (MELR) were assessed at 200 and 400 mg/kg.

Materials And Methods: In carrageenan-mediated paw edema, the anti-inflammatory effect of MELR was investigated and analgesic activity was assessed by central and peripheral models.

Results: MELR had strong analgesic and anti-inflammatory effects at different dosages (200 and 400 mg/kg). Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.60566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336040PMC

The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin.

Sci Rep 2020 Jul 7;10(1):11180. Epub 2020 Jul 7.

Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Von Willebrand factor (VWF) plays a major role in arterial thrombosis. Antiplatelet drugs induce only a moderate relative risk reduction after atherothrombosis, and their inhibitory effects are compromised under high shear rates when VWF levels are increased. Therefore, we investigated the ex vivo effects of a third-generation anti-VWF aptamer (BT200) before/after stimulated VWF release. Read More

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http://dx.doi.org/10.1038/s41598-020-68125-9DOI Listing

A nanotrap improves survival in severe sepsis by attenuating hyperinflammation.

Nat Commun 2020 Jul 7;11(1):3384. Epub 2020 Jul 7.

Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.

Targeting single mediators has failed to reduce the mortality of sepsis. We developed a telodendrimer (TD) nanotrap (NT) to capture various biomolecules via multivalent, hybrid and synergistic interactions. Here, we report that the immobilization of TD-NTs in size-exclusive hydrogel resins simultaneously adsorbs septic molecules, e. Read More

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http://dx.doi.org/10.1038/s41467-020-17153-0DOI Listing

Factors associated with early opioid dispensing compared with NSAID and muscle relaxant dispensing after a work-related low back injury.

Occup Environ Med 2020 Jul 7. Epub 2020 Jul 7.

Institute for Work and Health, Toronto, Ontario, Canada.

Objectives: The objective of this historical cohort study was to determine the claimant and prescriber factors associated with receiving opioids at first postinjury dispense compared with non-steroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants (SMRs) in a sample of workers' compensation claimants with low back pain (LBP) claims between 1998 and 2009 in British Columbia, Canada.

Methods: Administrative workers' compensation, prescription and healthcare data were linked. The association between claimant factors (sociodemographics, occupation, diagnosis, comorbidities, pre-injury prescriptions and healthcare) and prescriber factors (sex, birth year, specialty) with drug class(es) at first dispense (opioids vs NSAIDs/SMRs) was examined with multilevel multinomial logistic regression. Read More

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http://dx.doi.org/10.1136/oemed-2019-106380DOI Listing

Repeat Doses of Dexamethasone up to 48 Hours Further Reduce Pain and Inflammation After Total Hip Arthroplasty: A Randomized Controlled Trial.

J Arthroplasty 2020 Jun 17. Epub 2020 Jun 17.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Background: The optimal dose regimen of dexamethasone in total hip arthroplasty (THA) is unclear. This study was conducted to compare the effects among 1-dose, 2-dose, and 3-dose dexamethasone in THA.

Methods: One hundred fifty patients were randomized to receive a single preoperative dose of 10-mg dexamethasone (group A, 50 patients), or another dose of 10-mg dexamethasone 24 hours later (group B, 50 patients), or another 2 doses of 10-mg dexamethasone 24 and 48 hours later (group C, 50 patients). Read More

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http://dx.doi.org/10.1016/j.arth.2020.06.023DOI Listing

Matrine ameliorates cognitive deficits via inhibition of microglia mediated neuroinflammation in an Alzheimer's disease mouse model.

Pharmazie 2020 Jul;75(7):344-347

School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China;, Email:

Amyloid β (Aβ) induced microglial activation and attendant neuroinflammation play pivotal roles in Alzheimer's disease (AD) pathogenesis. Matrine is a natural anti-inflammation compound from the Chinese herbal medicine Ait. (Kushen). Read More

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http://dx.doi.org/10.1691/ph.2020.0395DOI Listing

5-methoxytryptophan: an arsenal against vascular injury and inflammation.

J Biomed Sci 2020 Jul 7;27(1):79. Epub 2020 Jul 7.

Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 35053, Taiwan.

5-methoxytryptophan (5-MTP) is an endothelial factor with anti-inflammatory properties. It is synthesized from L-tryptophan via two enzymatic steps: tryptophan hydroxylase-1 (TPH-1) and hydroxyindole O-methyltransferase. Lipopolysaccharide (LPS) and pro-inflammatory cytokines suppress endothelial 5-MTP production by inhibiting TPH-1 expression. Read More

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http://dx.doi.org/10.1186/s12929-020-00671-wDOI Listing
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