641,154 results match your criteria Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry [Journal]


A Phase 3, Randomized, Placebo-Controlled Evaluation of the Safety of Intravenous Meloxicam Following Major Surgery.

Clin Pharmacol Drug Dev 2019 Feb 20. Epub 2019 Feb 20.

Tampa General Hospital, Tampa, FL, USA.

An intravenous (IV) formulation of meloxicam is being studied for moderate to severe pain management. This phase 3, randomized, multicenter, double-blind, placebo-controlled trial evaluated the safety of once-daily meloxicam IV 30 mg in subjects following major elective surgery. Eligible subjects were randomized (3:1) to receive meloxicam IV 30 mg or placebo administered once daily. Read More

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http://dx.doi.org/10.1002/cpdd.666DOI Listing
February 2019

Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques.

PLoS One 2019 20;14(2):e0212649. Epub 2019 Feb 20.

PlantVax Corporation, Rockville, Maryland United States of America.

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in the crystallizable fragment (Fc) domains eg YTE (M252Y/S254T/T256E) and LS (M428L/N434S), as a consequence of increased half-lives and prolonged duration of protection. However, the functional properties of any biologic may be compromised by unanticipated immunogenicity in humans, rendering them ineffective. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212649PLOS
February 2019

Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.

PLoS One 2019 20;14(2):e0211436. Epub 2019 Feb 20.

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Gliadin, a component of wheat gluten known to be an important factor in the etiology of celiac disease, is related to several other diseases through its enhancing effect on intestinal paracellular permeability. We investigated the significance of gliadin in non-steroidal anti-inflammatory drug (NSAID)-induced small-intestinal damage in mice. 7-week-old C57BL/6 male mice were divided into the following groups: standard diet group, in which mice were fed with wheat-containing standard rodent diet (CE-2); gluten-free diet group, in which mice were fed with gluten-free diet (AIN-76A); and gliadin-administered group, in which mice fed with gluten-free diet were administered with gliadin (~250 mg/kg BW). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211436PLOS
February 2019

[Novel hepatokine in rheumatoid arthritis laboratory diagnostics.]

Klin Lab Diagn 2018 ;63(12):756-760

Federal State Budgetary Institution Institute of Clinical and Experimental Rheumatology named after A.B. Zborovsky, Volgograd.

Fetuin-A (α2-Heremans-Schmid glycoprotein, AHSG) is a glycoprotein mainly secreted by hepar in adults. It was shown, that AHSG is a positive as well as a negative acute-phase protein with pro- and anti-inflammatory effects. We studied serum levels of an AHSG in patients with rheumatoid arthritis (RA) and healthy controls in order to determine its role in the diagnostics of this disease. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-12-756-760DOI Listing
January 2018

[Renal risks of NSAIDs in endurance sports].

Rev Med Suisse 2019 Feb;15(639):444-447

Faculté de médecine, Université de Genève, 1205 Genève 4.

Endurance athletes, either professional or amateur, are consuming non steroidal anti-inflammatory drugs (NSAIDs) during their training and races. The goal is to decrease pain or to prevent a potential pain. These athletes, especially, the amateurs, do not do not know the side effects and have no medical supervision. Read More

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February 2019

Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications.

Braz J Med Biol Res 2019 Feb 14;52(2):e8209. Epub 2019 Feb 14.

Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha, Vila Velha, ES, Brasil.

Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264. Read More

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http://dx.doi.org/10.1590/1414-431X20188209DOI Listing
February 2019

Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).

Am J Physiol Lung Cell Mol Physiol 2019 Feb 20. Epub 2019 Feb 20.

Universidad Nacional Autonoma de Mexico.

MMP13 deficiency in pulmonary fibrosis have described contradictory phenotypes on inflammatory and fibrotic responses after lung injury and its role during lung fibrosis resolution is still undefined. MMP13 has been considered the main collagenase in rodents, and the remodeling of fibrillar collagen is widely attributed to the action of this enzyme. In this study we aimed to explore the role of MMP13 during lung fibrosis progression and resolution. Read More

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http://dx.doi.org/10.1152/ajplung.00455.2017DOI Listing
February 2019

Large-scale secretome analyses unveil the superior immunosuppressive phenotype of umbilical cord stromal cells as compared to other adult mesenchymal stromal cells.

Eur Cell Mater 2019 Feb 20;37:153-174. Epub 2019 Feb 20.

Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø,

Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about the divergence of these signalling molecules in different MSC populations. Read More

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http://dx.doi.org/10.22203/eCM.v037a10DOI Listing
February 2019

Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/mTOR/TGFβ1 signaling.

Int Immunopharmacol 2019 Feb 20;70:47-55. Epub 2019 Feb 20.

Dep. of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Electronic address:

Silicosis is a well acknowledged occupational lung disorder with considerable negative impact on the patients' quality of life. Various signaling pathways have been reported to interplay in the pathogenesis of pulmonary fibro-proliferative disorders; of which, P-AKT/mTOR signaling pathway. The current study highlights the potential pulmonary protective effect of carvedilol; a non-selective α/β blocker against experimental silicosis-induced in rats by the intranasal installation of silica (50 mg/rat, 1 ml 0. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.011DOI Listing
February 2019

Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation.

Int Immunopharmacol 2019 Feb 19;70:37-46. Epub 2019 Feb 19.

Neurophysiology Research Center, Department of Physiology, Shahed University, Tehran, Iran. Electronic address:

Diabetes mellitus (DM) is a prevalent metabolic disorder that is associated with development of some complications in male reproductive system including testicular damage, sexual dysfunction, abnormal spermatogenesis, and infertility. Diosgenin is a natural steroidal saponin with anti-diabetic, anti-oxidative, and anti-inflammatory effects. This research study was undertaken to explore the protective effect of diosgenin against diabetes-induced testicular damage in the rat. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.047DOI Listing
February 2019

Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway.

Int Immunopharmacol 2019 Feb 18;70:28-36. Epub 2019 Feb 18.

Department of Rehabilitation Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Electronic address:

Polydatin is a glucoside of resveratrol with lots of functional properties in the central nervous system, such as anti-edema, anti-oxidation and anti-inflammation. The purpose of this study was to evaluate the effects of polydatin on traumatic spinal cord injury (SCI) and explore the relative mechanisms. SCI models were established using the weight-drop method in rats, additionally, single polydatin administration (20, 40 mg/kg body weight) remarkably improved motor function of SCI rat, along with decreased nitric oxide (NO) generation and inflammatory factor (IL-1β, IL-6 and TNF-α) production in spinal cord tissues. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.006DOI Listing
February 2019

Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators.

Int Immunopharmacol 2019 Feb 18;70:16-27. Epub 2019 Feb 18.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Electronic address:

Anti-epileptic medications are included in the international guidelines for managing neuropathic pain. Valproate sodium (VPS) was recently described as "the forgotten analgesic" and has been reported to relief pain in various models of neuropathic pain. Some studies reported anti-inflammatory and histone deacetylase 1 (HDA1) inhibitory properties for sodium valproate. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.050DOI Listing
February 2019

Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo.

Int Immunopharmacol 2019 Feb 18;69:398-407. Epub 2019 Feb 18.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, West Xueyuan Road 109#, Wenzhou 325027, Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China. Electronic address:

Intervertebral disc degeneration is a multifactorial and complicated degenerative disease that imposes a huge economic burden on society. However, there is no effective treatment that can delay and reverse the progression of disc degeneration. The inflammatory response causes the death of nucleus pulposus cells and the degradation of extracellular matrix are main factors of intervertebral disc degeneration. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.004DOI Listing
February 2019

High activity of endogenous opioid system protects against gastric damage development in mouse models of gastric mucosal injury.

Pharmacol Rep 2018 Oct 25;71(2):218-224. Epub 2018 Oct 25.

Department of Biochemistry, Medical University of Lodz, Łódź, Poland. Electronic address:

Background: Gastric mucosal injury appears when acid and pepsin production, simultaneously with inadequate mucosal response, overwhelms protective mechanism in stomach. Here we aimed to explore the linkage between gastric lesion formation and endogenous opioid system activity.

Methods: Two mouse lines bidirectionally selected for high (HA) and low (LA) swim stress-induced analgesia associated with high and low endogenous opioid system activity were used. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.011DOI Listing
October 2018

Caffeic amide derivatives inhibit allergen-induced bone marrow-derived dendritic cell maturation.

Pharmacol Rep 2018 Nov 3;71(2):194-200. Epub 2018 Nov 3.

Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung, Taiwan; Department of Microbiology and Immunology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Background: Caffeic amides are derivatives of caffeic acid, which have antioxidant and anti-inflammatory properties, and high in vivo stability. The therapeutic effect of caffeic amides on allergic diseases, and especially on the maturation of bone marrow-derived dendritic cells (BM-DCs), remains unclear. In this study, we investigated the therapeutic potential of caffeic amides on allergic diseases by evaluating the maturation of DCs and evaluated their potential in inducing the differentiation of T2 cells. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.014DOI Listing
November 2018

Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats.

Colloids Surf B Biointerfaces 2019 Feb 14;177:389-398. Epub 2019 Feb 14.

Department of Medical Biochemistry, National Research Centre, Giza, Egypt.

This report focused on loading curcumin (CUR) drug into biodegradable Polylactide-poly(ethylene glycol) (PLA-PEG) copolymer nanoparticles as an effective anti-inflammatory agent in vivo to overcome the limitations resulted from the free CUR. By a simple nano-emulsification technique, hydrophobic CUR was loaded into hydrophobic polymer's segments and stabilized by cationic surfactant. They were then characterized by DLS, TEM, and SEM techniques providing monodispersed and spherical nanoparticles with an average diameter of 117 nm and high surface charge of +35 mV. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.024DOI Listing
February 2019

Huangkui capsule alleviates renal tubular epithelial-mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling.

Phytomedicine 2018 Dec 17;57:203-214. Epub 2018 Dec 17.

Institute of Huangkui, Suzhong Pharmaceutical Group Co., Ltd., 1 Suzhong Road, Taizhou, Jiangsu 225500, China. Electronic address:

Background: Huangkui capsule (HKC), an anti-inflammatory Chinese modern patent medicine, has been now widely applied to the clinical therapy of diabetic nephropathy (DN). However, the overall therapeutic mechanisms in vivo are still unclear. Renal tubular epithelial-to-mesenchymal transition (EMT) is one of the major pathogenesis of renal interstitial fibrosis in DN. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.021DOI Listing
December 2018

miR-16 inhibits NLRP3 inflammasome activation by directly targeting TLR4 in acute lung injury.

Biomed Pharmacother 2019 Feb 19;112:108664. Epub 2019 Feb 19.

Neonatal Medical Center, Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China. Electronic address:

Acute lung injury (ALI) is the leading cause of human death, and it is widely accepted that the runaway inflammation is an important risk for the development of ALI. In the present study, we aimed to investigate the effect of miR-16 on lipopolysaccharide-induced acute lung injury in mice, especially focusing on Toll-like receptor 4 (TLR4) and NF-kB signaling pathway as well as NOD-like receptor protein 3 (NLRP3) inflammasome activation. We established in vivo and in vitro model of ALI using LPS and demonstrated that miR-16 expression was down-regulated in lung tissue as well as A549 cells after 8 h of LPS treatment. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108664DOI Listing
February 2019

Bacterial cellulose membrane associated with red propolis as phytomodulator: Improved healing effects in experimental models of diabetes mellitus.

Biomed Pharmacother 2019 Feb 19;112:108640. Epub 2019 Feb 19.

Laboratory of Biotechnology of Natural and Synthetics Products, University of Caxias do Sul, Brazil. Electronic address:

Since early times, propolis has been used in folk medicine. The red propolis, collected in the northeast region of Brazil has been highlighted due to its popular use as an antimicrobial, with anti-inflammatory and healing properties, which are associated with its chemical composition. Here, we combine a bacterial membrane with red propolis to treat wounds of diabetic mice. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108640DOI Listing
February 2019

Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats.

Biomed Pharmacother 2019 Feb 20;112:108638. Epub 2019 Feb 20.

Department of Biomedical Sciences, Phytomedicine and Phytochemistry Research Group, Oxidative Stress Research Centre, Faculty of Health & Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville, 7535, South Africa. Electronic address:

Vindoline, an indole alkaloid present in the leaves of Catharanthus roseus plant, has been recently reported to have insulotropic effects. This present study evaluated the possible hepatoprotective effects of vindoline in a type 2 diabetes mellitus rat model. Diabetes mellitus was induced by exposing rats to 10% fructose water for two weeks followed by a single intraperitoneal injection of 40 mg/kg body weight of streptozotocin (STZ). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108638DOI Listing
February 2019

Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action.

Biomed Pharmacother 2019 Feb 19;112:108643. Epub 2019 Feb 19.

Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.

Biologically active compounds from species of the phylum Basidiomycota have been shown a wide range of pharmacological activities and provide a vast reservoir of potential innovational drugs. The aim of this review is to discuss some mechanisms of action involved in antioxidant, anti-inflammatory and cytotoxic/antitumoral activities attributed to the bioactive compounds from species of the phylum Basidiomycota. We show that isolated compounds from extracts, secondary metabolites and polysaccharides that presented antioxidant properties have mechanisms of action involved in the elimination/capture of free radicals and reduction of lipid peroxidation. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108643DOI Listing
February 2019

The effect of Xinkeshu tablets on depression and anxiety symptoms in patients with coronary artery disease: Results from a double-blind, randomized, placebo-controlled study.

Biomed Pharmacother 2019 Feb 19;112:108639. Epub 2019 Feb 19.

The Department of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China. Electronic address:

A large proportion of patients with coronary artery disease (CAD) suffer from depression or anxiety symptoms and this is associated with increased mortality [1]. This double-blinded, randomized, placebo-controlled, clinical trial (ChiCTR-IPR-17010940) aimed to explore whether Xinkeshu tablets can reduce anxiety or depressive symptoms in CAD patients and how this is related to the concentration of plasma cytokines. Sixty patients with CAD anda Hospital Anxiety and Depression Scale (HADS-a/HADS-d) score of ≥8 were treated with Xinkeshu tablets or placebo for 12 weeks following percutaneous revascularization. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108639DOI Listing
February 2019

Opuntioside, opuntiol and its metallic nanoparticles attenuate adjuvant-induced arthritis: Novel suppressors of Toll-like receptors -2 and -4.

Biomed Pharmacother 2019 Feb 20;112:108624. Epub 2019 Feb 20.

HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74270, Pakistan. Electronic address:

Rheumatoid arthritis (RA) is a chronic autoimmune disease of synovial inflammation and joint destruction. This study reports anti-arthritic potential of opuntioside-I opuntiol, and its gold and silver nanoparticles (NPs) against Complete Freund's Adjuvant (CFA)-induced arthritic rats. The mechanistic studies were performed targeting TLRs (TLR-2 and TLR-4) and cytokines (IL-1β and TNF-α) expressions to validate their anti-inflammatory and immuno-modulatory response. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108624DOI Listing
February 2019
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BW18, a C-21 steroidal glycoside, exerts an excellent anti-leukemia activity through inducing S phase cell cycle arrest and apoptosis via MAPK pathway in K562 cells.

Biomed Pharmacother 2019 Feb 19;112:108603. Epub 2019 Feb 19.

The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang 550014, China. Electronic address:

C-21 steroids displayed the activities of immunosuppressive, anti-inflammatory and anti-virus effects by the reports. However, its antitumor effects and molecular mechanism remain unclear. We previously isolated and identified a C-21 steroidal glycoside (BW18) from the root of Cynanchum atratum Bunge. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108603DOI Listing
February 2019

Lactobacillus rhamnosus GG strain mitigated the development of obstructive sleep apnea-induced hypertension in a high salt diet via regulating TMAO level and CD4 T cell induced-type I inflammation.

Biomed Pharmacother 2019 Feb 18;112:108580. Epub 2019 Feb 18.

Department of Respiratory, Affiliated Wuxi Fifth People's Hospital of Jiangnan University, Wuxi, 214016, China. Electronic address:

Obstructive sleep apnea (OSA) and high salt content in modern diet has been particularly implicated in systemic hypertension, leading to increased morbidity and mortality. Gut dysbiosis, associated with increased risk of systemic immunological imbalance, plays a causal role in the development of cardiovascular diseases. Here, we investigated the effect of Lactobacillus rhamnosus GG strain (LGG) on the development of hypertension induced by OSA and high salt diet. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.041DOI Listing
February 2019

Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and inflammation in high fat diet/streptozotocin treated rats.

Biomed Pharmacother 2019 Feb 19;112:108678. Epub 2019 Feb 19.

Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China. Electronic address:

The objective of this study was to evaluate the effect of the butanol fraction from Allium tuberosum (BFAT) in high fat diet/streptozotocin (HFD/STZ) induced diabetic nephropathy. Wistar rats were fed with HFD for 4 weeks and thereafter administered with 35 mg/kg STZ intraperitoneally. Diabetic rats were treated with BFAT (100 or 400 mg/kg) and metformin (150 mg/kg) for 40 days. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108678DOI Listing
February 2019

Tailoring the immune response to wheat gliadin by enzymatic transamidation.

Cytokine 2019 Feb 18;117:23-29. Epub 2019 Feb 18.

Institute of Food Sciences, CNR, 83100 Avellino, Italy. Electronic address:

Enzymatic transamidation of wheat gliadin by microbial transglutaminase inhibits IFN-γ secretion by intestinal T cell lines from celiac disease (CD) patients. Here, we analysed its effects on intestinal biopsies from CD patients and studied the underlying mechanisms in HLA-DQ8 transgenic (tg) mice, a model of T-cell mediated gluten sensitivity. In vitro challenge with a soluble form of transamidated gliadin (spf) upregulated IL-10 transcript levels in human biopsy samples. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.004DOI Listing
February 2019

New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo.

Eur J Med Chem 2019 Feb 13;167:377-387. Epub 2019 Feb 13.

Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China. Electronic address:

The great interest in epithelial-to-mesenchymal transition (EMT) programme lies in its association with process of metastasis and invasion, which is a crucial cause of cancer-related death. Herein, we designed and reported three new NSAID-Pt(IV) prodrugs, taking Non-Steroid Anti-Inflammatory Drugs (NSAIDs) to disrupt EMT programme and assist genotoxic platinum-based drugs as a cytotoxicity booster, to offer a class of potential anticarcinogens with a multi-functional action mechanism. The NSAID-Pt(IV) prodrugs, especially Eto-Pt(IV), highly enhanced cellular uptake with amount up to 42-fold at 3 h compared with CDDP, and greatly increased DNA damage and cell apoptosis, showing much higher cytotoxicity than cisplatin in the tested cancer cells even in A549/cis cells. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.041DOI Listing
February 2019

Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis.

J Neuroimmunol 2019 Feb 13;330:38-43. Epub 2019 Feb 13.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

Hypertrophic pachymeningitis (HP) is a rare neurologic disease causing inflammatory fibrous thickening of the brain and spinal dura mater. We investigated the cerebrospinal fluid cytokine profile of HP by measuring 28 cytokines/chemokines/growth factors with a multiplexed fluorescent immunoassay in 8 patients with HP (6 idiopathic, 1 IgG4-related, 1 anti-neutrophil cytoplasmic antibody-related), and 11 with other non-inflammatory neurologic diseases (OND). Interleukin (IL)-4, IL-5, IL-9, IL-10, TNF-α, and CXCL8/IL-8 levels were significantly higher in idiopathic HP (IHP) than OND. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.010DOI Listing
February 2019

Phenylethanoid glycosides of Phlomis younghusbandii Mukerjee ameliorate acute hypobaric hypoxia-induced brain impairment in rats.

Mol Immunol 2019 Feb 20;108:81-88. Epub 2019 Feb 20.

Department of Pharmacy, Shaanxi Provincial Hospital of Tuberculosis Prevention and Treatment, Xi'an 710100, PR China. Electronic address:

High altitude cerebral edema (HACE), whose development process is associated with oxidative stress and inflammatory response, is a life-threatening condition caused by rapid ascent speed to high altitudes. Phenylethanoid glycosides (PhGCs) are primary active constituents isolated from Phlomis younghusbandii Mukerjee that reportedly exhibit potent anti-oxidant and anti-inflammatory activities. The present study aims to investigate the protective effect of phenylethanoid glycosides (PhGCs) from P. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.02.002DOI Listing
February 2019

Fungal Translocation is Associated with Immune Activation and Systemic Inflammation in Treated HIV.

AIDS Res Hum Retroviruses 2019 Feb 20. Epub 2019 Feb 20.

Case Western Reserve University , 11100 Euclid AVe , Cleveland, Ohio, United States , 44106 ;

Background: The mechanisms causing HIV-associated immune activation remain incompletely understood. Alteration of intestinal integrity with subsequent translocation of bacterial products appears to play an important role; however, little is known about the impact of fungal translocation. We assessed the effect of fungal translocation and its association with immune activation in people living with HIV (PLWH) compared to uninfected controls. Read More

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http://dx.doi.org/10.1089/AID.2018.0252DOI Listing
February 2019

Dendrobeaniamine A, a new alkaloid from the Arctic marine bryozoan Dendrobeania murrayana.

Nat Prod Res 2019 Feb 20:1-6. Epub 2019 Feb 20.

a Marbio UiT-The Arctic University of Norway , Breivika , Tromsø , Norway.

The new guanidine alkaloid Dendrobeaniamine A (1) was isolated from the organic extract of the Arctic marine bryozoan Dendrobeania murrayana. The chemical structure of 1 was elucidated by spectroscopic experiments, including 1D and 2D NMR and HRESIMS analysis. Compound 1 is a lipoamino acid, consisting of a C fatty acid anchored to the amino acid arginine. Read More

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http://dx.doi.org/10.1080/14786419.2019.1574788DOI Listing
February 2019

Multimodal prevention of first psychotic episode through N-acetyl-l-cysteine and integrated preventive psychological intervention in individuals clinically at high risk for psychosis: Protocol of a randomized, placebo-controlled, parallel-group trial.

Early Interv Psychiatry 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.

Aim: Meta-analyses indicate positive effects of both antipsychotic and cognitive-behavioural interventions in subjects clinically at high risk (CHR) for psychosis in terms of a delay or prevention of psychotic disorders. However, these effects have been limited regarding social functioning and the relative efficacy of both types of interventions remains unclear. Furthermore, neuroprotective substances seem to be a promising alternative agent in psychosis-prevention as they are associated with few and weak side-effects. Read More

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http://dx.doi.org/10.1111/eip.12781DOI Listing
February 2019

Sirtuin 6 mitigated LPS-induced human umbilical vein endothelial cells inflammatory responses through modulating nuclear factor erythroid 2-related factor 2.

J Cell Biochem 2019 Feb 19. Epub 2019 Feb 19.

ICU, Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Background: Nuclear factor erythroid 2-related factor 2 (Nrf2) protects the lung from sepsis-induced injury through activating Nrf2-regulated multiple phase 2 detoxification genes, including NAD(P)H: quinine oxidoreductase-1 (NQO1) and heme oxygenase-1 (HO1). Based on the positive effect of Sirtuin 6 on Nrf2, we aim to explore the potential role of SIRT6 in the mechanism of sepsis-induced acute lung injury (ALI).

Methods: Mouse models of sepsis were constructed by instilling intratracheal of lipopolysaccharide (LPS; 4 ml/kg). Read More

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http://dx.doi.org/10.1002/jcb.28407DOI Listing
February 2019

The role of omega-3 in the prevention and treatment of sarcopenia.

Aging Clin Exp Res 2019 Feb 19. Epub 2019 Feb 19.

Division of Gerontology and Geriatrics, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.

Sarcopenia is a geriatric syndrome with increasing importance due to the aging of the population. It is known to impose a major burden in terms of morbidity, mortality and socio-economic costs. Therefore, adequate preventive and treatment strategies are required. Read More

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http://link.springer.com/10.1007/s40520-019-01146-1
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http://dx.doi.org/10.1007/s40520-019-01146-1DOI Listing
February 2019
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Propolis and Its Combination with Boric Acid Protect Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Inhibiting Oxidative Stress, Inflammation, DNA Damage, and Apoptosis in Rats.

Biol Trace Elem Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Chemistry, Faculty of Science, Dokuz Eylül University, Izmir, Turkey.

Ischemia reperfusion (I/R) injury which causes kidney dysfunction is one of the most studied diseases directly linked to oxidative stress. In this regard, it is important to protect cells against damage by inducing antioxidant response. Herein, we aimed to evaluate the therapeutic roles and possible mechanisms of propolis and boric acid in kidney I/R injury based on relevant basic research and clinical studies. Read More

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http://dx.doi.org/10.1007/s12011-019-1649-2DOI Listing
February 2019

Pterodontic acid isolated from Laggera pterodonta suppressed RIG-I/NF-KB/STAT1/Type I interferon and programmed death-ligand 1/2 activation induced by influenza A virus in vitro.

Inflammopharmacology 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, People's Republic of China.

Influenza viruses can bring about acute respiratory diseases and are a potential hazard to human health. Antiviral drugs are the main ways to control the influenza virus infection except the vaccine. In this study, the immune regulation activity of pterodontic acid isolated from Laggera pterodonta induced by influenza A virus in vitro was evaluated. Read More

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http://dx.doi.org/10.1007/s10787-019-00571-yDOI Listing
February 2019

The Controlled Release and Anti-Inflammatory Activity of a Tetramethylpyrazine-Loaded Thermosensitive Poloxamer Hydrogel.

Pharm Res 2019 Feb 19;36(4):52. Epub 2019 Feb 19.

Zhaoke (Hefei) Pharmaceutical Co. Ltd., Hefei, 230088, People's Republic of China.

Purpose: Tetramethylpyrazine-loaded poloxamer hydrogel materials were studied to achieve the controlled release of tetramethylpyrazine.

Methods: First, hydrogels having different concentrations of poloxamer 407 and poloxamer 188 were prepared. The gelling temperature and viscosity were measured. Read More

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http://dx.doi.org/10.1007/s11095-019-2580-0DOI Listing
February 2019

Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy.

AAPS J 2019 Feb 19;21(2):31. Epub 2019 Feb 19.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 228, 160 Frelinghuysen Road, Piscataway, New Jersey, 08854, USA.

Moringa isothiocyanate (MIC-1) is the main active isothiocyanate found in Moringa oleifera, a plant consumed as diet and traditional herbal medicine. Compared to sulforaphane (SFN), MICs are less studied and most work have focused on its anti-inflammatory activity. The purpose of this study is to better understand the Nrf2-ARE antioxidant activity of MIC-1 and its potential in diabetic nephropathy. Read More

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http://dx.doi.org/10.1208/s12248-019-0301-6DOI Listing
February 2019

Activators of SIRT1 in wound repair: an animal model study.

Arch Dermatol Res 2019 Feb 19. Epub 2019 Feb 19.

Graduate Program in Biomedical Sciences, Centro Universitário da Fundação Hermínio Ometto, FHO, Av. Maximiliano Barutto 500, Jardim Universitário, Araras, SP, 13607-339, Brazil.

Caloric restriction (CR) and resveratrol activate SIRT1 and induce anti-inflammatory and antioxidant properties. We perform excisional lesion on the dorsum of four groups anesthetized animals: ad libitum-AL diet, AL diet with topical application of 2% resveratrol-Rv, 30% calorie restricted, and finally 30% calorie restricted with 2% resveratrol and we examine CR and Rv effects in wound repair. Restricted animals remained with CR for 31 days. Read More

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http://dx.doi.org/10.1007/s00403-019-01901-4DOI Listing
February 2019

Oxygen in the tumor microenvironment: effects on dendritic cell function.

Oncotarget 2019 Jan 25;10(8):883-896. Epub 2019 Jan 25.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Solid tumors grow at a high speed leading to insufficient blood supply to tumor cells. This makes the tumor hypoxic, resulting in the Warburg effect and an increased generation of reactive oxygen species (ROS). Hypoxia and ROS affect immune cells in the tumor micro-environment, thereby affecting their immune function. Read More

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http://dx.doi.org/10.18632/oncotarget.26608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368231PMC
January 2019

Protective effect of Xin-Ji-Er-Kang on cardiovascular remodeling in high salt-induced hypertensive mice.

Exp Ther Med 2019 Mar 17;17(3):1551-1562. Epub 2018 Dec 17.

Department of Pharmacology, Basic Medical College, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

The aim of the present study was to investigate the effects of Xin-Ji-Er-Kang (XJEK) on high salt-induced hypertensive mice. Mice with high-salt diet-induced hypertension were divided into four groups: Control (standard diet alone for 8 weeks), model (diet containing 8% NaCl for 8 weeks and intragastric administration of distilled water for the last 4 weeks), XJEK + high-salt-treated (diet containing 8% NaCl for 8 weeks and intragastric administration of XJEK for the last 4 weeks) and irbesartan + high-salt-treated (diet containing 8% NaCl for 8 weeks with intragastric administration of irbesartan for the last 4 weeks). The hemodynamic index and cardiac pathological changes in the hypertensive mice were then examined. Read More

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http://dx.doi.org/10.3892/etm.2018.7105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364186PMC

study on anti-oxidant and anti-inflammatory properties of (aqueous extract): A polyherbal formulation.

Ayu 2018 Apr-Jun;39(2):81-86

Department of Studies in Biotechnology, Manasagangotri, University of Mysore, Mysuru, Karnataka, India.

Background: Plants used in (VMD) formulation were investigated individually by many scientists. Most of them have exhibited antioxidant, anti-inflammatory and antimicrobial activities when they have been extracted with the different solvents. Here, an attempt has been made to analyze these activities in aqueous extract of the whole formulation. Read More

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http://dx.doi.org/10.4103/ayu.AYU_225_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369607PMC
February 2019

Analgesic and anti-inflammatory activities of Wight. pseudobulb: A folklore plant.

Ayu 2018 Apr-Jun;39(2):76-80

Head, Pharmacology Laboratory, IIPGT and RA, GAU, Jamnagar, Gujarat, India.

Background: Wight. is an epiphytic orchid used extensively by the tribes of Karnataka in various diseases such as heart disease, leukoderma, skin allergy and rheumatism. It is used both internally and as an external application. Read More

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http://dx.doi.org/10.4103/ayu.AYU_134_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369610PMC
February 2019

A clinical evaluation of and in the management of with special reference to benign prostatic hyperplasia.

Ayu 2018 Apr-Jun;39(2):65-71

Department of Shalya Tantra, IPGT and RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.

Background: a disease of (urinary system) described in Ayurveda, closely resembles with benign prostatic hyperplasia (BPH) of the modern medicine. It affects man above the age of 40 years. Conservative management with hormonal therapy, open prostatectomy and TURP are the options available in modern medicine. Read More

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http://dx.doi.org/10.4103/ayu.AYU_117_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369605PMC
February 2019
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Sulfated polysaccharides of seagrass suppresses tumor necrosis factor-α-induced chemokine interleukin-8 secretion in HT-29 cell line.

Indian J Pharmacol 2018 Nov-Dec;50(6):336-343

Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry, India.

Objectives: The present study aims to investigate the anti-oxidant and anti-inflammatory properties of seagrass sulfated polysaccharide on HT-29 cell line.

Subjects And Methods: Monosaccharides composition was identified using liquid chromatography-mass spectrometry (LC-MS) and the functional groups were analyzed using Fourier transform-infrared (FT-IR) spectroscopy. The antioxidant and anti-inflammatory potential of crude extract and purified fractions was investigated . Read More

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http://dx.doi.org/10.4103/ijp.IJP_202_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364340PMC
February 2019

Codonopsis lanceolata attenuates allergic lung inflammation by inhibiting Th2 cell activation and augmenting mitochondrial ROS dismutase (SOD2) expression.

Sci Rep 2019 Feb 19;9(1):2312. Epub 2019 Feb 19.

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.

Allergic asthma is a chronic inflammatory disease induced by the inhalation of allergens, which trigger the activation of T helper type 2 (Th2) cells that release Th2 cytokines. Recently, herbal medicines are being considered a major source of novel agents to treat various diseases. In the present study, we evaluated the anti-asthmatic effects of a Codonopsis lanceolata extract (CLE) and the mechanisms involved in its anti-inflammatory effects. Read More

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http://dx.doi.org/10.1038/s41598-019-38782-6DOI Listing
February 2019

Interleukin 17A promotes diabetic kidney injury.

Sci Rep 2019 Feb 19;9(1):2264. Epub 2019 Feb 19.

Kidney Node Laboratory, The Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, Australia.

The role of the pro-inflammatory cytokine IL-17 in the pathogenesis of numerous inflammatory disorders is well-documented, but conflicting results are reported for its role in diabetic nephropathy. Here we examined the role of IL-17 signalling in a model of streptozotocin-induced diabetic nephropathy through IL-17 knockout mice, administration of neutralising monoclonal anti-IL-17 antibody and in vitro examination of gene expression of renal tubular cells and podocytes under high glucose conditions with or without recombinant IL-17. IL-17 deficient mice were protected against progression of diabetic nephropathy, exhibiting reduced albuminuria, glomerular damage, macrophage accumulation and renal fibrosis at 12 weeks and 24 weeks. Read More

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http://dx.doi.org/10.1038/s41598-019-38811-4DOI Listing
February 2019

Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi.

Sci Rep 2019 Feb 19;9(1):2304. Epub 2019 Feb 19.

Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.

Intestinal pathology in children with complicated severe acute malnutrition (SAM) persists despite standard management. Given the similarity with intestinal pathology in non-IgE mediated gastrointestinal food allergy and Crohn's disease, we tested whether therapeutic feeds effective in treating these conditions may benefit children with complicated SAM. After initial clinical stabilisation, 95 children aged 6-23 months admitted at Queen Elizabeth Central Hospital, Blantyre, Malawi between January 1 and December 31, 2016 were allocated randomly to either standard feeds, an elemental feed or a polymeric feed for 14 days. Read More

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http://www.nature.com/articles/s41598-019-38690-9
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http://dx.doi.org/10.1038/s41598-019-38690-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381085PMC
February 2019
2 Reads

A potential peptide derived from cytokine receptors can bind proinflammatory cytokines as a therapeutic strategy for anti-inflammation.

Sci Rep 2019 Feb 19;9(1):2317. Epub 2019 Feb 19.

Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien, 97004, Taiwan.

Chronic inflammation is a pivotal event in the pathogenesis of cardiovascular diseases, including atherosclerosis, restenosis, and coronary artery disease. The efficacy of current treatment or preventive strategies for such inflammation is still inadequate. Thus, new anti-inflammatory strategies are needed. Read More

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http://dx.doi.org/10.1038/s41598-018-36492-zDOI Listing
February 2019
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