674,167 results match your criteria Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry [Journal]


Anti-cytokines as a Strategy in Alpha-1 Antitrypsin Deficiency.

Chronic Obstr Pulm Dis 2020 Jun 5;7(3). Epub 2020 Jun 5.

Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.

For many years, the lung disease associated with alpha-1 antitrypsin (AAT) deficiency (AATD) was perceived as being secondary to an imbalance between this serine protease inhibitor and the target protease, neutrophil elastase (NE). More recently, a greater understanding of the pathways leading to lung inflammation has shed light on new potential attributes and presented AATD as an inflammatory condition in which proteases and neutrophils still play a major role, but in which pro-inflammatory cytokines, either induced by the actions of NE or by other pro-inflammatory processes normally modulated by AAT, are involved. In this review, we will look at the various cytokines centrally involved in AATD lung disease, and how a greater understanding of their contribution may help development of targeted therapies. Read More

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http://dx.doi.org/10.15326/jcopdf.7.3.2019.0171DOI Listing

Co-effects of C/Ag dual ion implantation on enhancing antibacterial ability and biocompatibility of silicone rubber.

Biomed Mater 2020 Jun 5. Epub 2020 Jun 5.

Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Xinqiao Road, Sha Ping Ba District, Chongqing, 400037, People's Republic of China., Chongqing, 400038, CHINA.

Although silicone implants are the most popular choice around the world for breast augmentation, reconstruction, and revision, due to the poor antibacterial properties and limited biocompatibility of silicone rubber (SR), one of the major complications, capsule contracture, is a lingering problem. To overcome the two main shortcomings, dual ion implantation technique was applied to modify the surface of SR with the basic skeleton element of organic matters, carbon (C) and the broad-spectrum bactericide, silver (Ag). We present surface characterization, toxicological effects, and evaluation of the mechanical, antibacterial and biocompatible properties of C and Ag co-implanted SR (C/Ag-SRs). Read More

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http://dx.doi.org/10.1088/1748-605X/ab99d3DOI Listing

Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats.

J Pharm Biomed Anal 2020 May 25;188:113376. Epub 2020 May 25.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:

Alpha-viniferin is a trimer of resveratrol and has various pharmacological activities including anti-Alzheimer's disease, anti-tuberculosis, anti-tumor, anti-inflammatory and anti-diabetic. To investigate the pharmacokinetic characteristics and absolute bioavailability of α-viniferin in rats, using naringenin as an internal standard (IS), a rapid HPLC-MS/MS method of 5 min complete run time was developed. The chromatographic separation of α-viniferin and naringenin were accomplished with Waters XBridge™ C column (2. Read More

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http://dx.doi.org/10.1016/j.jpba.2020.113376DOI Listing

IL-38 alleviates the inflammatory response and the degeneration of nucleus pulposus cells via inhibition of the NF-κB signaling pathway in vitro.

Int Immunopharmacol 2020 May 12;85:106592. Epub 2020 May 12.

Department of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, People's Republic of China. Electronic address:

Previous studies have suggested that the inflammatory response contributes to the onset of intervertebral disc degeneration (IVDD). Interleukin (IL)-38, a newly discovered cytokine of the IL-1 family, has been demonstrated to play an anti-inflammatory role in autoimmune diseases, such as Crohn's disease, rheumatoid arthritis and psoriasis. However, whether IL-38 participates in the pathogenesis of IVDD remains unknown. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106592DOI Listing

Evaluation of different dosages of doxycycline during the adulticide treatment of heartworm (Dirofilaria immitis) in dogs.

Vet Parasitol 2020 Jun 2;283:109141. Epub 2020 Jun 2.

Internal Medicine, Faculty of Veterinary Medicine, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Spain.

The endosymbiont bacteria Wolbachia plays an important role in the pathogenesis and inflammatory immune response to heartworm (Dirofilaria immitis) infection in dogs. Doxycycline is used to reduce Wolbachia from all life stages of heartworm to avoid large releases of the bacteria during the death of the worms. However, the dose and duration currently recommended have been extrapolated from the treatment of other rickettsial infections. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109141DOI Listing

Combined exposure to hypoxia and ammonia aggravated biological effects on glucose metabolism, oxidative stress, inflammation and apoptosis in largemouth bass (Micropterus salmoides).

Aquat Toxicol 2020 May 16;224:105514. Epub 2020 May 16.

College of Animal Science and Technology, Sichuan Agricultural University (SICAU), Chengdu, Sichuan 611130, China. Electronic address:

Hypoxia and ammonia are unavoidable environmental factors in aquaculture, and have been shown cause various adverse effects in fish. In the present study, a two-factor crossover experiment was carried out to evaluate the combined effect of hypoxia and ammonia on oxidative stress and glucose metabolism endpoints in largemouth bass. The fish were divided into four experimental groups: hypoxia and ammonia group, hypoxia group, ammonia group, and control group. Read More

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http://dx.doi.org/10.1016/j.aquatox.2020.105514DOI Listing

Isorhamnetin: A review of pharmacological effects.

Biomed Pharmacother 2020 Jun 2;128:110301. Epub 2020 Jun 2.

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, PR China. Electronic address:

Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110301DOI Listing

The impact of blue light in monolayers representing tumorigenic and nontumorigenic cell membranes containing epigallocatechin-3-gallate.

Colloids Surf B Biointerfaces 2020 May 21;193:111129. Epub 2020 May 21.

CEFITEC, Departamento de Física, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal. Electronic address:

Natural products such as epigallocatechin-3-gallate (EGCG) have been suggested for complementary treatments of cancer, since they lower toxic side effects of anticancer drugs, and possess anti-inflammatory and antioxidant properties that inhibit carcinogenesis. Their effects on cancer cells depend on interactions with the membrane, which is the motivation to investigate Langmuir monolayers as simplified membrane models. In this study, EGCG was incorporated in zwitterionic dipalmitoyl phosphatidyl choline (DPPC) and anionic dipalmitoyl phosphatidyl serine (DPPS) Langmuir monolayers to simulate healthy and cancer cells membranes, respectively. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2020.111129DOI Listing

Timosaponin AIII attenuates inflammatory injury in AGEs-induced osteoblast and alloxan-induced diabetic osteoporosis zebrafish by modulating the RAGE/MAPK signaling pathways.

Phytomedicine 2020 May 24;75:153247. Epub 2020 May 24.

Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, 310007, China.. Electronic address:

Background: Advanced glycation end products (AGEs) deposition causes inflammatory injury in osteoblasts and contributes to diabetic osteoporosis. The receptor for advanced glycation end product/mitogen-activated protein kinase pathway (RAGE/MAPK) signaling pathway is closely linked to the pathogenesis of diabetic osteoporosis. Timosaponin AIII, a steroidal saponin isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), shows anti-inflammatory and anti-osteoporosis effects. Read More

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http://dx.doi.org/10.1016/j.phymed.2020.153247DOI Listing

Efficacy and safety of canakinumab treatment in schnitzler syndrome: A systematic literature review.

Semin Arthritis Rheum 2020 May 25;50(4):636-642. Epub 2020 May 25.

Department of general internal medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of clinical infectious and inflammatory disease, department of Microbiology, Immunology and Transplantation, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.

Background: Schnitzler syndrome is a rare autoinflammatory disorder characterized by chronic urticarial rash and a monoclonal gammopathy, accompanied by intermittent fever, bone pain, and arthralgia or arthritis. Canakinumab is a fully human monoclonal anti-interleukin-1β (IL-1β) antibody proven to be effective in IL-1 driven autoinflammatory disorders.

Methods: We systematically searched PubMed and Embase to include all types of studies on canakinumab treatment in Schnitzler syndrome published until March 16, 2020. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.05.002DOI Listing

Potential role of statins in COVID-19.

Int J Infect Dis 2020 Jun 2. Epub 2020 Jun 2.

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.

Patients with COVID-19 infection have an increased risk of cardiovascular complications and thrombotic events. Statins are known for their pleiotropic anti-inflammatory, antithrombotic and immunomodulatory effects. They may have a potential role as adjunctive therapy to mitigate the effects of endothelial dysfunction and dysregulated inflammation in patients with COVID-19 infection. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.115DOI Listing

IL-34 regulates the inflammatory response and anti-bacterial immune defense of Japanese flounder Paralichthys olivaceus.

Fish Shellfish Immunol 2020 Jun 2. Epub 2020 Jun 2.

CAS Key Laboratory of Experimental Marine Biology, CAS Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China. Electronic address:

Interleukin (IL)-34 is a relatively recently discovered cytokine with pleiotropic effects on various cellular activities, including immune response. In fish, the knowledge on the function of IL-34 is limited. In the present work, we investigated the function of Japanese flounder Paralichthys olivaceus IL-34 (PoIL-34) in association with inflammation and immune defense. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.05.073DOI Listing

Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury.

Brain Res Bull 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, China. Electronic address:

Cognitive decline is one of the most obvious symptoms of traumatic brain injury (TBI). Previous studies have demonstrated that cognitive decline is related to substantially increased neuroinflammation and decreased neurogenesis in the hippocampus in a rat model of TBI. Using this model, we explored the role of curcumin (Cur) in ameliorating TBI-impaired spatial memory because Cur has been shown to exhibit anti-chronic-neuroinflammatory, neurogenesis-promoting, and memory-improving properties. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2020.05.009DOI Listing

C16 peptide and angiopoietin-1 protect against LPS-induced BV-2 microglial cell inflammation.

Life Sci 2020 Jun 2:117894. Epub 2020 Jun 2.

Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, China. Electronic address:

Aims: Pathological alterations in the brain can cause microglial activation (MA). Thus, inhibiting MA could provide a new approach for treating neurodegenerative disorders.

Main Methods: To investigate the effect of C16 peptide and angiopoietin-1 (Ang1) on inflammation following MA, we stimulated microglial BV-2 cells with lipopolysaccharide (LPS) and used dexmedetomidine (DEX) as a positive control. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117894DOI Listing

Tocilizumab administration in a refractory case of COVID-19.

Int J Antimicrob Agents 2020 Jun 2:106043. Epub 2020 Jun 2.

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Novel coronavirus (COVID-19) pneumonia as a pandemic disease leads to acute respiratory distress syndrome (ARDS), acute cardiac injury, multi organ failure, and shock. In the absence of specific treatment for COVID-19, there is an urgent need to find the alternative treatments to manage this pandemic. Pathophysiological studies have demonstrated the role of inflammatory mediators in COVID-19 pneumonia. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106043DOI Listing

The pivotal role of SUMO-1-JNK-Tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin.

Biochem Pharmacol 2020 Jun 2:114066. Epub 2020 Jun 2.

Laboratory of Neuropharmacology, EBRI Rita Levi-Montalcini Foundation, Rome, Italy; Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran; Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Milan, Italy. Electronic address:

Oxidative stress is a toxic cellular condition, strictly related to inflammation and known to be a common feature of many neurodegenerative diseases. The imbalanced redox state modifies several molecular processes including protein SUMOylation, JNK and Tau protein activation, important actors in Alzheimer's disease. In this study, we showed a strong interaction among SUMO-1-JNK-Tau proteins and their molecular targets in an in vitro model (SHSY5Y cell line) of oxidative stress in which a significant reduction of cell viability and an augmented cell death was induced by increased doses of H2O2. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114066DOI Listing

Toxoplasma gondii infection impairs radial glia differentiation and its potential to modulate brain microvascular endothelial cell function in the cerebral cortex.

Microvasc Res 2020 Jun 2:104024. Epub 2020 Jun 2.

Laboratório de Neurobiologia Celular, ICB, UFRJ, Brazil. Electronic address:

Congenital toxoplasmosis is a parasitic disease that occurs due vertical transmission of the protozoan Toxoplasma gondii (T. gondii) during pregnancy. The parasite crosses the placental barrier and reaches the developing brain, infecting progenitor, glial, neuronal and vascular cell types. Read More

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http://dx.doi.org/10.1016/j.mvr.2020.104024DOI Listing

Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group.

Lancet Oncol 2020 Jun;21(6):e330-e336

Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

Optimising the conduct of clinical trials for diffuse intrinsic pontine glioma involves use of consistent, objective disease assessments and standardised response criteria. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. A working group was formed specifically to address response assessment in children and young adults with diffuse intrinsic pontine glioma and to develop a consensus on recommendations for response assessment. Read More

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http://dx.doi.org/10.1016/S1470-2045(20)30166-2DOI Listing

Nanomedicine for the treatment of rheumatoid arthritis.

Mol Pharm 2020 Jun 5. Epub 2020 Jun 5.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in severe inflammatory microenvironments in the joint tissues. In clinics, disease-modifying anti-rheumatic drugs (DMARDs) are generally prescribed to patients with RA, but their long-term use often shows toxicity in some organs such as gastro-intestine, skin, and kidney, and immunosuppression-mediated infection. Nanomedicine has emerged as a new therapeutic strategy to efficiently localize the drugs in inflamed joints for the treatment of RA. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00295DOI Listing

Prescription Patterns of Opioids and Non-Steroidal Anti-Inflammatory Drugs in the First Year After Living Kidney Donation: An Analysis of U.S. Registry and Pharmacy Fill Records.

Clin Transplant 2020 Jun 5:e14000. Epub 2020 Jun 5.

Center for Abdominal Transplantation, Saint Louis University, St. Louis, MO, USA.

We examined a novel database linking national donor registry identifiers to records from a U.S. pharmaceutical claims warehouse (2007-2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0-14 days, 15-182 days, and 183-365 days. Read More

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http://dx.doi.org/10.1111/ctr.14000DOI Listing

Uric acid and uric acid to creatinine ratio in the assessment of chronic obstructive pulmonary disease: Potential biomarkers in multicomponent models comprising IL-1beta.

PLoS One 2020 5;15(6):e0234363. Epub 2020 Jun 5.

Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.

Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease, with oxidative stress and inflammation implicated in its development. Uric acid (UA) could exert anti-oxidative, pro-oxidative or pro-inflammatory effects, depending on the specific context. It was recently shown that soluble UA, and not just its crystals, could activate the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to interleukin (IL)-1β secretion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234363PLOS

Ex-Vivo Lung Perfusion Improves the Inflammatory Signalling Profile of the Porcine Donor Lung Following Transplantation.

Transplantation 2020 Jun 2. Epub 2020 Jun 2.

Background: Primary graft dysfunction and allograft rejection represent major caveats to successful lung transplantation. Reducing inflammation in donor lungs prior to transplantation may improve outcomes. Evidence exists that ex-vivo lung perfusion (EVLP) can alter the donor lung environment, although the mechanisms remain unclear. Read More

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http://dx.doi.org/10.1097/TP.0000000000003338DOI Listing

Effects of Granulocyte Macrophage Colony-Stimulating Factor Inhibition on the Skin/Nerve Cell Model In Vitro.

J Craniofac Surg 2020 Jun 4. Epub 2020 Jun 4.

Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea.

The present study is based on the concept of neuro-aging and how it may affect surrounding skin cells. It has been shown that many factors play a significant role in skin homeostasis by interfering with various cytokines, either through activation or inhibition. Granulocyte macrophage colony-stimulating factor (GM-CSF) is generally recognized as an inflammatory cytokine, and our previous study has shown its effects on neuronal senescence after ultraviolet (UV) irradiation of skin cells. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006411DOI Listing

Comparison and evaluation of non-invasive models in predicting liver inflammation and fibrosis of chronic hepatitis B virus-infected patients with high hepatitis B virus DNA and normal or mildly elevated alanine transaminase levels.

Medicine (Baltimore) 2020 Jun;99(23):e20548

Department of Clinical Laboratory, The Second Hospital of Anhui Medical University.

Few studies have paid attention to the performances of non-invasive models in diagnosing stages of liver fibrosis and inflammation, which are critical for early and accurate assessment of prognostication and decisions on antiviral treatment in chronic hepatitis B infection patients with high hepatitis B virus DNA and normal or mildly elevated alanine transaminase levels (≤2 times upper limit of normal (ULN)). This study aimed to investigate the value of routine serum markers in evaluation of liver inflammation and fibrosis in these patients.A total of 370 consecutive chronic hepatitis B virus-infected patients who underwent liver biopsy were retrospectively analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000020548DOI Listing

Novel Orally Administered Recombinant Anti-TNF Alpha Fusion Protein for the Treatment of Ulcerative Colitis: Results From a Phase 2a Clinical Trial.

J Clin Gastroenterol 2020 Jun 3. Epub 2020 Jun 3.

Hadassah Medical Center, Jerusalem, Israel.

Background And Objective: OPRX-106 is an orally administered BY2 plant cell-expressing recombinant TNF fusion protein (TNFR). Oral administration of OPRX-106 was shown to be safe and effective in inducing favorable anti-inflammatory immune modulation in humans. The current study was aimed at determining the safety and efficacy of OPRX-106 in patients with ulcerative colitis (UC). Read More

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http://dx.doi.org/10.1097/MCG.0000000000001314DOI Listing

Estimation of equipotent doses for anti-inflammatory effects of prednisolone and AZD9567, an oral selective non-steroidal glucocorticoid receptor modulator.

CPT Pharmacometrics Syst Pharmacol 2020 Jun 5. Epub 2020 Jun 5.

Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

AZD9567 is a potent and selective non-steroidal oral glucocorticoid receptor modulator. It is developed as an anti-inflammatory drug with improved safety profile compared to steroids like prednisolone. Throughout the clinical development of AZD9567, dose selection and data interpretation require a method for determining doses with the same anti-inflammatory effect as prednisolone. Read More

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http://dx.doi.org/10.1002/psp4.12536DOI Listing

Phytochemical and biological characterization of methanolic extracts from Rumex algeriensis and Rumex tunetanus.

Chem Biodivers 2020 Jun 5. Epub 2020 Jun 5.

Universita degli Studi di Messina, ChiBioFarAm, Viale Annunziata, Messina, ITALY.

The present study is aimed at the evaluation of the phytochemical profile and the biochemical properties of methanolic extracts obtained from different parts of Rumex algeriensis and Rumex tunetanus , two relict species limited to the North Africa. Phytochemical analyses of these extracts were performed using standard colorimetric procedures, HPLC-DAD, and HPLC-DAD-ESI/MS, and their antioxidant/free radical scavenging capability was estimated through several in vitro cell-free assays. Moreover, the anti-inflammatory potential of these extracts was demonstrated in an in vitro model of acute intestinal inflammation using differentiated Caco-2 cells. Read More

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http://dx.doi.org/10.1002/cbdv.202000345DOI Listing

Can network pharmacology identify the anti-virus and anti- inflammatory activities of Shuanghuanglian oral liquid used in Chinese medicine for respiratory tract infection?

Eur J Integr Med 2020 Aug 26;37:101139. Epub 2020 May 26.

The First Affiliated Hospital of Guangdong University of Chinese Medicine, No.12, Airport Road, Baiyun District, Guangzhou 510405, China.

Introduction: Shuanghuanglian (SHL) oral liquid is a well-known traditional Chinese medicine preparation administered for respiratory tract infections in China. However, the underlying pharmacological mechanisms remain unclear. The present study aims to determine the potential pharmacological mechanisms of SHL oral liquid based on network pharmacology. Read More

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http://dx.doi.org/10.1016/j.eujim.2020.101139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255237PMC

Effects of pH on salicylic acid toxicity in terms of biomarkers determined in the marine gastropod Gibbula umbilicalis.

Mar Environ Res 2020 Jun 21;158:104995. Epub 2020 Apr 21.

Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos S/N, 4450-208, Matosinhos, Portugal; Faculdade de Ciências da Saúde da Universidade Fernando Pessoa (FCS/UFP), Rua Carlos da Maia 296, 4200-150, Porto, Portugal.

Alterations of the physical-chemical properties of the oceans due to anthropogenic activities are, at present, one of the most concerning environmental issues studied by researchers. One of these issues is ocean acidification, mainly caused by overproduction and release of carbon dioxide (CO) from anthropogenic sources. Another component of environmental degradation is related to the production and release of potential toxic compounds, namely active pharmaceutical ingredients, into the aquatic environment that, combined with oceanic acidification, can cause unpredictable and never before considered deleterious effects on non-target marine organisms. Read More

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http://dx.doi.org/10.1016/j.marenvres.2020.104995DOI Listing

Methane Alleviates Inflammation and Apoptosis of Dextran Sulfate Sodium-Induced Inflammatory Bowel Diseases by Inhibiting Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Factor 88 (MyD88)/Nuclear Translocation of Nuclear Factor-κB (NF-κB) and Endoplasmic Reticulum Stress Pathways in Mice.

Med Sci Monit 2020 Jun 5;26:e922248. Epub 2020 Jun 5.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China (mainland).

BACKGROUND Inflammatory bowel diseases (IBDs) are chronic idiopathic diseases with increased occurrence and recurrence rates. The aim of this study was to explore whether methane-rich saline (MRS) would be beneficial to IBD. MATERIAL AND METHODS Dextran sulfate sodium (DSS) was utilized to establish an IBD model. Read More

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http://dx.doi.org/10.12659/MSM.922248DOI Listing

Naringin inhibits titanium particles-induced up-regulation of TNF-α and IL-6 via the p38 MAPK pathway in fibroblasts from hip periprosthetic membrane.

Connect Tissue Res 2020 Jun 5. Epub 2020 Jun 5.

Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai, 200233, China.

Aims: Inflammatory responses to wear debris cause osteolysis that leads to aseptic loosening and hip arthroplasty failure. Wear debris stimulate macrophages and fibroblasts to secret proinflammatory cytokines, including TNF-α and IL-6, which have been specifically implicated in periprosthetic osteolysis and osteoclast differentiation. Naringin has anti-inflammatory effect in macrophages. Read More

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http://dx.doi.org/10.1080/03008207.2020.1778680DOI Listing

Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?

Scand Cardiovasc J 2020 Jun 5:1-6. Epub 2020 Jun 5.

Coronary Care Unit, Division of Internal Medicine, Nordland Hospital, Bodø, Norway.

. Inflammatory responses are closely knit with low-density lipoprotein (LDL)-cholesterol in driving atherosclerosis. Even if LDL-cholesterol is causative to atherosclerotic diseases and LDL-cholesterol lowering reduces hard clinical endpoints, there is a residual risk for clinical events, possibly driven by inflammatory processes, in accordance with its role in autoimmune diseases. Read More

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http://dx.doi.org/10.1080/14017431.2020.1775878DOI Listing

Human Decidua Basalis mesenchymal stem/stromal cells reverse the damaging effects of high level of glucose on endothelial cells in vitro.

J Cell Mol Med 2020 Jun 5. Epub 2020 Jun 5.

Stem Cells and Regenerative Medicine Department, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Recently, we reported the therapeutic potential of mesenchymal stem/stromal cells (MSCs) from the maternal decidua basalis tissue of human term placenta (DBMSCs) to treat inflammatory diseases, such as atherosclerosis and cancer. DMSCs protect endothelial cell functions from the negative effects of oxidative stress mediators including hydrogen peroxide (H O ) and monocytes. In addition, DBMSCs induce the generation of anti-cancer immune cells known as M1 macrophages. Read More

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http://dx.doi.org/10.1111/jcmm.15248DOI Listing

Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement.

Allergy 2020 Jun 5. Epub 2020 Jun 5.

Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.

The outbreak of the SARS-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Read More

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http://dx.doi.org/10.1111/all.14407DOI Listing

The Antidiabetic Metformin as an Adjunct to Antidepressants in Patients with Major Depressive Disorder: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial.

Neurotherapeutics 2020 Jun 4. Epub 2020 Jun 4.

Department of Clinical Pharmacy, Faculty of Pharmacy, Delta University for Science and Technology, Gamasaa, Egypt.

Metformin (MET) has been reported to have antidepressant effects in animal models and in diabetic patients with depression, owing to its anti-inflammatory, antioxidant, and neuroprotective activity. Accordingly, we proposed that MET would show antidepressant effects in patients with major depressive disorder (MDD) without other comorbidities. In this double-blind placebo-controlled study, 80 adult outpatients with MDD (DSM-IV criteria) and a Hamilton Depression Rating Scale (HAM-D) score >18 were randomized to receive fluoxetine 20 mg once daily plus placebo (n = 40) or fluoxetine 20 mg once daily plus MET 1000 mg once daily for 12 weeks. Read More

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http://dx.doi.org/10.1007/s13311-020-00878-7DOI Listing

Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial-mesenchymal transition.

Biotechnol Lett 2020 Jun 4. Epub 2020 Jun 4.

Department of Gastroenterology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, China.

Cancer metastasis is the primary cause of death in patients diagnosed with colorectal cancer. Piperine, an active nontoxic ingredient in pepper, has potent anti-inflammatory and anti-cancer properties. However, little is known about the anti-migratory and anti-invasive effects of piperine on colorectal cancer. Read More

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http://dx.doi.org/10.1007/s10529-020-02923-zDOI Listing

Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice.

Neurochem Res 2020 Jun 5. Epub 2020 Jun 5.

Programa de Pós-Graduação Em Bioquímica E Bioprospecção - Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas E de Alimentos, Universidade Federal de Pelotas, Campus Universitário s/n, Pelotas, RS, CEP: 96010-900, Brazil.

Depression is an emotional disorder that causes mental and physical changes, and has limited pharmacotherapy. Tannic acid (TA) is a polyphenol with previously described antioxidant and neuroprotective properties. The aim of this study was to evaluate the effects of TA on lipopolysaccharide (LPS)-induced depressive-like behavior, as well as oxidative stress parameters and TNF-α levels in the brains of mice. Read More

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http://dx.doi.org/10.1007/s11064-020-03064-5DOI Listing

COVID-19 and heme oxygenase: novel insight into the disease and potential therapies.

Authors:
Philip L Hooper

Cell Stress Chaperones 2020 Jun 4. Epub 2020 Jun 4.

Division of Endocrinology and Metabolism, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

The COVID-19 pandemic needs therapies that are presently available and safe. We propose that subjects with metabolic syndrome, old age, and male gender have the greatest morbidity and mortality and have low stress proteins, in particular, low intracellular heme oxygenase (HO-1), making them particularly vulnerable to the disease. Additionally, COVID-19's heme reduction may contribute to even lower HO-1. Read More

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http://dx.doi.org/10.1007/s12192-020-01126-9DOI Listing

Rescue of HSP70 in Spinal Neurons Alleviates Opioids-Induced Hyperalgesia via the Suppression of Endoplasmic Reticulum Stress in Rodents.

Front Cell Dev Biol 2020 12;8:269. Epub 2020 May 12.

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, China.

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opioids. Endoplasmic reticulum (ER) stress has been shown to contribute to neuropathic or inflammatory pain, but its roles in opioids-induced hyperalgesia (OIH) are elusive. Here, we provide the first direct evidence that ER stress is a significant driver of OIH. Read More

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http://dx.doi.org/10.3389/fcell.2020.00269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243285PMC

Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects.

Front Bioeng Biotechnol 2020 15;8:467. Epub 2020 May 15.

Food Security and Safety Niche, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, South Africa.

Endophytes are abundant in plants and studies are continuously emanating on their ability to protect plants from pathogens that cause diseases especially in the field of agriculture. The advantage that endophytes have over other biocontrol agents is the ability to colonize plant's internal tissues. Despite this attributes, a deep understanding of the mechanism employed by endophytes in protecting the plant from diseases is still required for both effectiveness and commercialization. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242734PMC

Airway Epithelial Cell Immunity Is Delayed During Rhinovirus Infection in Asthma and COPD.

Front Immunol 2020 15;11:974. Epub 2020 May 15.

Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW, Australia.

Respiratory viral infections, particularly those caused by rhinovirus, exacerbate chronic respiratory inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Airway epithelial cells are the primary site of rhinovirus replication and responsible of initiating the host immune response to infection. Numerous studies have reported that the anti-viral innate immune response (including type I and type III interferon) in asthma is less effective or deficient leading to the conclusion that epithelial innate immunity is a key determinant of disease severity during a rhinovirus induced exacerbation. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243842PMC

Regulation of T Cell Activities in Rheumatoid Arthritis by the Novel Fusion Protein IgD-Fc-Ig.

Front Immunol 2020 15;11:755. Epub 2020 May 15.

Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and T cell hyper-activation. Emerging evidence has shown that the stimulation of immunoglobulin D (IgD) induces T cell activation and may contribute to disease pathogenesis. In this study, the sIgD concentrations were positively associated with disease activity score in 28 joints (DAS28) and anti-cyclic citrullinated peptide (anti-CCP) in RA. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243948PMC

A Review of the Effects of Natural Compounds, Medicinal Plants, and Mushrooms on the Gut Microbiota in Colitis and Cancer.

Front Pharmacol 2020 15;11:744. Epub 2020 May 15.

Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

The human gastrointestinal tract harbors a diverse array of microorganisms that play fundamental roles in health and disease. Imbalance in the gut microbiota, namely dysbiosis, can lead to various diseases, including cancer and gastrointestinal tract disorders. Approaches to improve gut dysbiosis, such as dietary intervention, intake of probiotics, and fecal microbiota transplantation are emerging strategies to treat these diseases. Read More

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http://dx.doi.org/10.3389/fphar.2020.00744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243258PMC

Bakuchiol Attenuates Oxidative Stress and Neuron Damage by Regulating Trx1/TXNIP and the Phosphorylation of AMPK After Subarachnoid Hemorrhage in Mice.

Front Pharmacol 2020 15;11:712. Epub 2020 May 15.

Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.

Subarachnoid hemorrhage (SAH) is a fatal cerebrovascular condition with complex pathophysiology that reduces brain perfusion and causes cerebral functional impairments. An increasing number of studies indicate that early brain injury (EBI), which occurs within the first 72 h of SAH, plays a crucial role in the poor prognosis of SAH. Bakuchiol (Bak) has been demonstrated to have multiorgan protective effects owing to its antioxidative and anti-inflammatory properties. Read More

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http://dx.doi.org/10.3389/fphar.2020.00712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243250PMC

Neuroimmunomodulatory and Neuroprotective Effects of the Flavonoid Apigenin in Models of Neuroinflammation Associated With Alzheimer's Disease.

Front Aging Neurosci 2020 15;12:119. Epub 2020 May 15.

Laboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Av. Reitor Miguel Calmon S/N, Federal University of Bahia (UFBA), Salvador, Brazil.

Neurodegenerative disorders (ND) are characterized by the progressive and irreversible loss of neurons. Alzheimer's Disease (AD) is the most incident age-related ND, in which the presence of a chronic inflammatory compound seems to be related to its pathogenesis. Different stimuli in the central nervous system (CNS) can induce activation, proliferation, and changes in phenotype and glial function, which can be modulated by anti-inflammatory agents. Read More

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http://dx.doi.org/10.3389/fnagi.2020.00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243840PMC

miR-379 links glucocorticoid treatment with mitochondrial response in Duchenne muscular dystrophy.

Sci Rep 2020 Jun 4;10(1):9139. Epub 2020 Jun 4.

Généthon INSERM, UMR_S951, INTEGRARE research unit, Evry, 91000, France.

Duchenne Muscular Dystrophy (DMD) is a lethal muscle disorder, caused by mutations in the DMD gene and affects approximately 1:5000-6000 male births. In this report, we identified dysregulation of members of the Dlk1-Dio3 miRNA cluster in muscle biopsies of the GRMD dog model. Of these, we selected miR-379 for a detailed investigation because its expression is high in the muscle, and is known to be responsive to glucocorticoid, a class of anti-inflammatory drugs commonly used in DMD patients. Read More

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http://dx.doi.org/10.1038/s41598-020-66016-7DOI Listing

A novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas aeruginosa.

Sci Rep 2020 Jun 4;10(1):9117. Epub 2020 Jun 4.

Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand.

Antimicrobial peptides (AMPs) are promising alternatives to classical antibiotics for the treatment of drug-resistant infections. Due to their versatility and unlimited sequence space, AMPs can be rationally designed by modulating physicochemical determinants to favor desired biological parameters and turned into novel therapeutics. In this study, we utilized key structural and physicochemical parameters, in combination with rational engineering, to design novel short α-helical hybrid peptides inspired by the well-known natural peptides, cathelicidin and aurein. Read More

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http://dx.doi.org/10.1038/s41598-020-65688-5DOI Listing

Evaluation of prescription pattern of analgesic use among ambulatory elderly in South-Western Nigeria.

Ann Afr Med 2020 Apr-Jun;19(2):131-136

Chief Tony Anenih Geriatric Centre, University College Hospital, Ibadan, Nigeria.

Background: Inappropriate prescribing of analgesics has a global impact on the health of elderly patients and the society. Empirical evidence on the prescription of analgesics among elderly Nigerians is scarce.

Objectives: The objective of the study was to evaluate the prescription pattern of analgesics and describe the co-prescribing of gastroprotective agents with non-steroidal anti-inflammatory drugs (NSAIDs) among elderly patients at the geriatric center, University College Hospital, Ibadan. Read More

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http://dx.doi.org/10.4103/aam.aam_57_19DOI Listing

NSAIDs for analgesia in the era of COVID-19.

Reg Anesth Pain Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Globally, non-steroidal anti-inflammatory drugs (NSAIDs) are highly used to treat pain. With the rise of the COVID-19 pandemic, the safety of NSAIDs use has been called into question. These concerns are worthy of review. Read More

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http://dx.doi.org/10.1136/rapm-2020-101584DOI Listing

Effects of soybean isoflavones on the growth performance, intestinal morphology and antioxidative properties in pigs.

Animal 2020 Jun 5:1-9. Epub 2020 Jun 5.

Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing100081, China.

Soybean meal is rich in soybean isoflavones, which exhibit antioxidant, anti-inflammatory, antiviral and anticancer functions in humans and animals. This study was conducted to investigate the effects of soybean isoflavones on the growth performance, intestinal morphology and antioxidative properties in pigs. A total of 72 weaned piglets (7. Read More

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http://dx.doi.org/10.1017/S1751731120001123DOI Listing
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