Antiinfect Agents Med Chem 2009 Apr;8(2):87-101
Mayo Clinic College of Medicine, Division of Infectious Diseases, Rochester, MN, 55905, USA.
TNF-related apoptosis inducing ligand (TRAIL) is a key mediator of the innate immune response to infection. While TRAIL-mediated apoptosis plays an essential role in the clearance of virus-infected cells, its physiologic role also includes immunosurveilance for cancer cells. Therapeutics that induce TRAIL-mediated apoptosis in cancer cells remain a focus of ongoing investigation in clinical trials, and much has been learned from these studies regarding the efficacy and toxicity of these interventions. Read More