1,601,678 results match your criteria Anti-Infective Agents in Medicinal Chemistry[Journal]


Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates.

Commun Biol 2018 7;1:221. Epub 2018 Dec 7.

1Synthetic Biology Group, MIT Synthetic Biology Center; The Center for Microbiome Informatics and Therapeutics; Research Laboratory of Electronics, Department of Biological Engineering, and Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

Antimicrobial peptides (AMPs) constitute promising alternatives to classical antibiotics for the treatment of drug-resistant infections, which are a rapidly emerging global health challenge. However, our understanding of the structure-function relationships of AMPs is limited, and we are just beginning to rationally engineer peptides in order to develop them as therapeutics. Here, we leverage a physicochemical-guided peptide design strategy to identify specific functional hotspots in the wasp-derived AMP polybia-CP and turn this toxic peptide into a viable antimicrobial. Read More

View Article
December 2018

biofilms: effects of physicochemical factors, virulence, antibiotic resistance determinants, gene regulation, and future antimicrobial treatments.

Infect Drug Resist 2018 15;11:2277-2299. Epub 2018 Nov 15.

Virology and Microbiology Research Group, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa,

is a leading cause of nosocomial infections due to its increased antibiotic resistance and virulence. The ability of to form biofilms contributes to its survival in adverse environmental conditions including hospital environments and medical devices. has undoubtedly propelled the interest of biomedical researchers due to its broad range of associated infections especially in hospital intensive care units. Read More

View Article
November 2018

Thesaurus for off-label indications for systemic antifungal agents.

Med Mal Infect 2018 Dec 4. Epub 2018 Dec 4.

Service pharmacie, groupement hospitalier Nord, hospices civils de Lyon, Lyon, France; Comité des anti-infectieux, hospices civils de Lyon, Lyon, France.

Objectives: Following the removal of temporary treatment protocol procedures, we developed a thesaurus for off-label indications for systemic antifungals at our facility to update clinical practices and to control off-label prescriptions.

Materials And Methods: Clinical practice guidelines and literature data were analyzed. This work was part of an antifungal stewardship program. Read More

View Article
December 2018

A Photon-Responsive Antibacterial Nanoplatform for Synergistic Photothermal-/Pharmaco- Therapy of Skin Infection.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Abuse of antibiotics and their residues in the environment result in the emergence and prevalence of drug-resistant bacteria and lead to serious health problems. Herein, a photon-controlled antibacterial platform that can efficiently kill drug-resistant bacteria and avoid the generation of new bacterial resistance was designed by encapsulating black phosphorus quantum dots (BPQDs) and pharmaceutical inside a thermal-sensitive liposome. The antibacterial platform can release pharmaceutical in a spatial-, temporal- and dosage-controlled fashion since the BPQDs can delicately generate heat under near-infrared (NIR) light stimulation to disrupt the liposome. Read More

View Article
December 2018
2 Reads

Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents.

Pharm Res 2018 Dec 5;36(1):22. Epub 2018 Dec 5.

Department Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), 66123, Saarbrücken, Germany.

Purpose: The objective of this work was to evaluate the potential of polymeric spherical and aspherical invasive nanocarriers, loaded with antibiotic, to access and treat intracellular bacterial infections.

Methods: Aspherical nanocarriers were prepared by stretching of spherical precursors, and both aspherical and spherical nanocarriers were surface-functionalized with the invasive protein InvA497. The relative uptake of nanocarriers into HEp-2 epithelial cells was then assessed. Read More

View Article
December 2018
1 Read

Non-standard treatment for uncomplicated urogenital infections: a systematic review.

BMJ Open 2018 Dec 4;8(12):e023808. Epub 2018 Dec 4.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To review the literature for non-standard treatment options for uncomplicated (CT) infections in adolescents and adults.

Design: Systematic review.

Data Sources: Ovid MEDLINE/PubMed, Ovid EMBASE, Cochrane Trials & Systematic Review Databases, CINAHL Plus with Full Text, Web of Science Core Collection, Scopus, ProQuest Dissertations & Theses Global, ClinicalTrials. Read More

View Article
December 2018

Evaluation of anti-infectives prescriptions in a pediatric hemato-oncological center: A retrospective study.

J Oncol Pharm Pract 2018 Dec 5:1078155218816779. Epub 2018 Dec 5.

1 Analytical chemistry laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Introduction: A few years after the discovery and development of anti-infectives, this therapeutic feat gave way to bacterial resistance because of the overconsumption of antibiotics, most often with unjustified prescriptions. The objective was to evaluate the compliance of the prescription of antibiotherapy in the pediatric onco-hematology unit of Rabat Children's Hospital and to determine the drug interactions.

Material And Methods: This is a retrospective study of anti-infectives prescriptions in pediatric onco-hematology. Read More

View Article
December 2018

A Nationwide Study in Denmark of the Association Between Treated Infections and the Subsequent Risk of Treated Mental Disorders in Children and Adolescents.

JAMA Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.

Importance: Infections have been associated with increased risks for mental disorders, such as schizophrenia and depression. However, the association between all infections requiring treatment and the wide range of mental disorders is unknown to date.

Objective: To investigate the association between all treated infections since birth and the subsequent risk of development of any treated mental disorder during childhood and adolescence. Read More

View Article
December 2018

Syphilitic uveitis misdiagnosed as viral retinitis-a misleading history.

J Ophthalmic Inflamm Infect 2018 Dec 4;8(1):22. Epub 2018 Dec 4.

Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, Baba Kharak Singh Marg, New Delhi, 110001, India.

Background: Syphilitic uveitis is an infective uveitis and a great mimicker. Misdiagnosis can lead to delay in the specific treatment resulting in deterioration of uveitis and loss of vision.

Findings: A 38-year-old unmarried female presented with pain, redness, and blurring of vision in the left eye for the last 5 days. Read More

View Article
December 2018
4 Reads

Patient preferences for treatment of acute bacterial skin and skin structure infections in the emergency department.

BMC Health Serv Res 2018 Dec 4;18(1):932. Epub 2018 Dec 4.

Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA.

Background: Limited research has assessed patient preferences for treatment disposition and antibiotic therapy of acute bacterial skin and skin structure infection (ABSSSI) in the emergency department (ED). Understanding patient preference for the treatment of ABSSSI may influence treatment selection and improve satisfaction.

Methods: A survey was conducted across 6 US hospital EDs. Read More

View Article
December 2018
1 Read

Impact of tetracationic calix[4]arene conformation - from conic structure to expanded bolaform- on their antibacterial and antimycobacterial activities.

Chembiochem 2018 Dec 4. Epub 2018 Dec 4.

FRANCE.

The four possible conformers of a new tetra-guanidino calix[4]arene thought to interact deleteriously with bacterial membrane were synthesized, characterized and evaluated for their in vitro antibacterial activity against various reference Gram negative and Gram positive bacteria: E. coli, P. aeruginosa, S. Read More

View Article
December 2018
1 Read
3.090 Impact Factor

[S2k guidelines of the PEG on calculated parenteral initial treatment of bacterial diseases in adults : Focussed summary and supplementary information on antibiotic treatment of critically ill patients].

Anaesthesist 2018 Dec;67(12):936-949

Stabsstelle Klinische Mikrobiologie und Krankenhaushygiene, Klinikum der Universität München, Campus Großhadern, München, Deutschland.

In January 2018 the recent revision of the S2k guidelines on calculated parenteral initial treatment of bacterial diseases in adults-update 2018 (Editor: Paul Ehrlich Society for Chemotherapy, PEG) was realized. It is a helpful tool for the complex infectious disease setting in an intensive care unit. The present summary of the guidelines focuses on the topics of anti-infective agents, including new substances, pharmacokinetics and pharmacodynamics as well as on microbiology, resistance development and recommendations for calculated drug therapy in septic patients. Read More

View Article
December 2018
2 Reads

Mutations in and Correlate With Daptomycin Resistance in .

Antimicrob Agents Chemother 2018 Dec 3. Epub 2018 Dec 3.

Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, TX

We investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (/ sub-group) from daptomycin (DAP)-naïve patients to develop DAP resistance All strains rapidly developed high-level and stable DAP-resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified: CdsA (phosphatidate cytidylyltransferase) and/or PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3-phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. Read More

View Article
December 2018
1 Read

Is One Sample Enough? β-lactam Target Attainment and Penetration into Epithelial Lining Fluid based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model.

Antimicrob Agents Chemother 2018 Dec 3. Epub 2018 Dec 3.

Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA

Describing the disposition of antimicrobials agents at the site of infection is crucial to guide optimal dosing for investigational agents. For antibiotics in development for nosocomial pneumonia, concentrations are frequently determined in the epithelial lining fluid (ELF) of the lung from a bronchoscopy at a single time point. The influence of profiles constructed from a single ELF concentration point for each subject has never been reported. Read More

View Article
December 2018

Exploring the biology and structural architecture of sortase roleon Biofilm formation in gram positive pathogens.

Curr Top Med Chem 2018 Nov 30. Epub 2018 Nov 30.

Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Lab, Alagappa University, Science Block, Karaikudi-630003, Tamilnadu. India.

Gram-positive bacteria signify a surface organelle that decorates the cell surfaces using Sortase enzymes. The mechanism of SrtC lings to the formation of amide or peptide bonds between cell surface proteins that sorting signal to strategically positioned amino groups. Sorting signals linked to peptidoglycan function as the principal architects of cell wall and facilitate each microbe to effectively interact with its host environment. Read More

View Article
November 2018
1 Read

Enterocutaneous fistula in severely active Crohn's disease: preoperative anti-TNF alpha treatment to limit bowel resection-report of a case.

Int J Colorectal Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery and Transplantation, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany.

Purpose: Strategies for limiting the extent of bowel resection in cases of enterocutaneous or interenteric fistulas in severely active Crohn's disease are urgently necessary. Anti-inflammatory therapy with tumor necrosis factor alpha (anti-TNF alpha) inhibitors has positive impact on fistulizing Crohn's disease. We describe a case of a 32-year-old male suffering from enterocutaneous fistula in severely active Crohn's disease. Read More

View Article
November 2018
4 Reads

Musculoskeletal manifestations in pediatric patients infected with human immunodeficiency virus: Developing country perspective.

Eur J Rheumatol 2018 Oct 12. Epub 2018 Oct 12.

Department of Pediatric Medicine, Kolkata Medical College, Kolkata, India.

Objective: Musculoskeletal manifestations in children infected with human immunodeficiency virus (HIV) are responsible for increased morbidity and decreased quality of life. Even in this era of highly active anti-retroviral therapy (HAART), there are limited studies on different rheumatological manifestations in pediatric patients with HIV, and the spectrum of musculoskeletal manifestation in pediatric HIV is yet to be established.

Methods: A single-center, prospective, observational study was carried out from October 2014 to September 2016 in a tertiary care hospital of Eastern India with 517 children infected with HIV aged between 3 and 19 years. Read More

View Article
October 2018

Exogenous 3-Deoxyglucosone-Induced Carbonyl and Oxidative Stress Causes β-Cells Dysfunction by Impairing Gut Permeability in Rats.

Biochemistry (Mosc) 2018 Nov;83(11):1358-1368

Suzhou Academy of Wumen Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu, China.

3-Deoxyglucosone (3DG) is a highly reactive dicarbonyl species, and its accumulation evokes carbonyl and oxidative stress. Our recent data reveal the role of 3DG as an independent factor for the development of prediabetes and suggest that intestine could be its novel target tissue. The present study investigated whether exogenous 3DG increases intestinal permeability by triggering carbonyl and oxidative stress, thus contributing to β-cell dysfunction. Read More

View Article
November 2018

A transcriptome analysis of the ameliorate effect of Cyclocarya paliurus triterpenoids on ethanol stress in Saccharomyces cerevisiae.

World J Microbiol Biotechnol 2018 Nov 26;34(12):182. Epub 2018 Nov 26.

Department of Agriculture and Biotechnology, Wenzhou Vocational College of Science and Technology, Wenzhou, 325006, People's Republic of China.

Saccharomyces cerevisiae (S. cerevisiae) plays a critical role in ethanol fermentation. However, during the fermentation, yeast cells are exposed to the accumulation of ethanol, which significantly affect the cell growth and the target product yield. Read More

View Article
November 2018

Diagnosis and Management of Pediatric Influenza in the Era of Rapid Diagnostics.

J Pediatric Infect Dis Soc 2018 Nov 22. Epub 2018 Nov 22.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, Pennsylvania.

Influenza is a significant cause of childhood morbidity and death; it contributes to up to 16% of hospitalizations for respiratory illnesses worldwide. Novel rapid viral diagnostic tests, including molecular diagnostic tests, have the potential to significantly affect both time to diagnosis and selection of optimal anti-infective therapy. However, little is known about current treatment algorithms used in US hospitals. Read More

View Article
November 2018

Thermodynamic Study of Interactions of Distamycin A with Chromatin in Rat Liver Nuclei in the Presence of Polyamines.

Biochemistry (Mosc) 2018 Oct;83(10):1231-1244

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.

We studied the thermodynamics of melting of isolated rat liver nuclei with different degrees of chromatin condensation determined by the concentration of polyamines (PA) and the solution ionic strength, as well as the effect of the antibiotic distamycin A (DM) on melting. Differential scanning calorimetry (DSC) profiles of nuclear preparations contained three peaks that reflected melting of three main chromatin domains. The number of peaks did not depend on the degree of condensation; however, nuclei with more condensed chromatin had a higher total enthalpy. Read More

View Article
October 2018

Hydrophobic Derivatives of Glycopeptide Antibiotics as Inhibitors of Protein Kinases.

Biochemistry (Mosc) 2018 Oct;83(10):1222-1230

Gause Institute of New Antibiotics, Moscow, 119021, Russia.

As key regulators of cell signaling, protein kinases (PKs) are attractive targets for therapeutic intervention in a variety of diseases. Herein, we report for the first time the inhibitory activity of polycyclic peptides, particularly, derivatives of glycopeptide antibiotics teicoplanin and eremomycin, against a panel of 12 recombinant human protein kinases and two protein kinases (CK1 and CK2) isolated from rat liver. Several of the investigated compounds inhibited various PKs with IC values below 10 μM and caused >90% suppression of the enzyme activity at 10 µM concentration. Read More

View Article
October 2018
2 Reads

Recovery of Impaired Memory: Expression of c-Fos and Egr-1 Transcription Factors during Restoration of Damaged Engram in the Chick Brain.

Biochemistry (Mosc) 2018 Sep;83(9):1117-1123

P. K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russia.

Impairment of protein synthesis in the brain during learning prevents memory consolidation and results in amnesia, which until recently has been regarded irreversible. However, in some cases impaired memory could be restored by various "reminder" stimuli. The present study is based on the hypothesis that even in behaviorally profound amnesia, some disintegrated fragments of the engram are preserved in the brain and could be re-integrated into the whole system by specific types of stimuli. Read More

View Article
September 2018

Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by gram-negative bacilli: a systematic review.

Int J Antimicrob Agents 2018 Nov 22. Epub 2018 Nov 22.

Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4006, Australia.

Background: . Knowledge of antibiotic concentrations achievable in the epithelial lining fluid (ELF) will help guide antibiotic dosing for treating patients with gram-negative bacillary ventilator-associated pneumonia (VAP).

Objective: . Read More

View Article
November 2018
4 Reads

Inhibition of alpha-hemolysin expression by resveratrol attenuates Staphylococcus aureus virulence.

Microb Pathog 2018 Nov 20;127:85-90. Epub 2018 Nov 20.

College of Animal Husband and Veterinary, Jinzhou Medical University, Key Laboratory of Quality and Safety Engineering of Animal Products of Liaoning Province, Jinzhou 121000, PR China. Electronic address:

Staphylococcus aureus is an important zoonotic pathogen that causes a variety of life-threatening diseases. The increasing emergence of drug resistance further complicates the treatment of S. aureus infections. Read More

View Article
November 2018
3 Reads
2.000 Impact Factor

The 9-Fluoren Vinyl Ether Derivative SAM461 Inhibits Bacterial Luciferase Activity and Protects From Luminescent Vibriosis.

Front Cell Infect Microbiol 2018 8;8:368. Epub 2018 Nov 8.

Instituto Universitario de Bio-Orgánica "Antonio González", Centro de Investigaciones Biomédicas de Canarias, Universidad de La Laguna, Tenerife, Spain.

is a major pathogen in aquaculture. It is a causative agent of the so-called "luminescent vibriosis," a life-threatening condition caused by bioluminescent spp. that often involves mass mortality of farmed shrimps. Read More

View Article
November 2018
2 Reads

Injection of Urethral Bulking Agents.

Urol Clin North Am 2019 Feb;46(1):1-15

Urinary Tract and Pelvic Reconstruction, Department of Urology, MD Anderson Cancer Center, Unit 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

Urethral injection is a safe and minimally invasive method of treating female stress urinary incontinence with multiple bulking agents currently commercially available. Although there are numerous studies that demonstrate efficacy, long-term success is not yet proven. This article aims to describe the mechanism of action and properties of various agents, patient selection factors, available techniques for injection, outcomes of urethral injections, and complications associated with the procedure. Read More

View Article
February 2019
1 Read

The Revolution in Treatment of Hepatitis C.

Med Clin North Am 2019 Jan;103(1):43-55

Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. Electronic address:

Treatment of hepatitis C with interferon therapy produced some cures early on, but was associated with significant side effects. Because of further advances in the molecular understanding of hepatitis C, by 2014 effective treatments became available that far surpassed all prior interferon-based regimens in efficacy, tolerability, and safety. This led to rapid transformation of a hard-to-treat disease to simple, safe, and effective treatment offered to anyone. Read More

View Article
January 2019
8 Reads

Efficacy of Direct-Acting Antivirals in Patients with Hepatitis C Virus/Human Immunodeficiency Virus Coinfection: A Gap between Clinical Trial and Real Practice.

Authors:
Do Young Kim

Gut Liver 2018 11;12(6):609-610

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

View Article
November 2018
3 Reads

Evaluation of the sub-optimal induction strategies for heterologous proteins production by Pichia pastoris Mut/Mut strains and related transcriptional and metabolic analysis.

World J Microbiol Biotechnol 2018 Nov 21;34(12):180. Epub 2018 Nov 21.

The Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Ave, Wuxi, 214122, China.

Heterologous proteins induction by methylotrophic recombinant Pichia pastoris is generally implemented at high cells density condition. Methanol concentration (MeOH) and dissolved oxygen concentration (DO) are two crucial operating parameters controlling proteins production. It is difficult to control MeOH/DO at their desired levels simultaneously due to the extremely high oxygen consumption features. Read More

View Article
November 2018
2 Reads

Transcripts of antibacterial peptides in chicken erythrocytes infected with Marek's disease virus.

BMC Vet Res 2018 Nov 21;14(1):363. Epub 2018 Nov 21.

College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, China.

Background: Chicken erythrocytes are involved in immunity through binding of toll-like receptors (TLRs) with their ligands to activate downstream signaling and lead to cytokine production in erythrocytes. Some avian β-defensins (AvBDs) are constitutively expressed in tissues and some others can be induced by various bacteria and viruses. However, the expression of AvBDs in erythrocytes has not yet been studied extensively. Read More

View Article
November 2018
5 Reads

Gastric Mammalian Target of Rapamycin Signaling Contributes to Inhibition of Ghrelin Expression Induced by Roux-En-Y Gastric Bypass.

Cell Physiol Biochem 2018 21;51(2):664-680. Epub 2018 Nov 21.

Department of Physiology, School of Medicine, Jinan University, Guangzhou,

Background/aims: Roux-en-Y Gastric Bypass, RYGB, is the most effective strategy to control body weight in morbid obesity. RYGB leads to rapid improvement of glycemic status and weight loss, which are largely attributed to the alteration of gastrointestinal hormones including ghrelin. The current study examined potential mechanisms of altered ghrelin synthesis after RYGB. Read More

View Article
December 2018
5 Reads

The Designer Antimicrobial Peptide A-hBD-2 Facilitates Skin Wound Healing by Stimulating Keratinocyte Migration and Proliferation.

Cell Physiol Biochem 2018 21;51(2):647-663. Epub 2018 Nov 21.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,

Background/aims: Antimicrobial peptides are effective promoters of wound healing but are susceptible to degradation. In this study, we replaced the GIGDP unit on the N-terminal of the endogenous human antimicrobial peptide hBD-2 with APKAM to produce A-hBD-2 and analyzed the effect on wound healing both in vitro and in vivo.

Methods: The effects of A-hBD-2 and hBD-2 on cytotoxicity and proliferation in keratinocytes were assessed by Cell Counting Kit-8 assay. Read More

View Article
December 2018
2 Reads

Coccidioidomycosis: first cases reported in Pernambuco, Brazil.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e75. Epub 2018 Nov 14.

Universidade Federal de Pernambuco, Departamento de Micologia, Recife, Pernambuco, Brazil.

Coccidioidomycosis is a fungal infection caused by Coccidioides immitis or Coccidioides posadasii. These fungi are known to thrive in desert climate. Fungi produce infectious arthroconidia in soil, they are aerosolized in the air and when inhaled by humans, usually cause infections such as pneumonia. Read More

View Article
November 2018
4 Reads

Quality of life of Brazilian chronic hepatitis C patients treated with interferon-free therapies.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e72. Epub 2018 Nov 14.

Universidade Federal do Paraná, Programa de Pós-Graduação em Assistência Farmacêutica, Curitiba, Paraná, Brazil.

Due to the severity of chronic hepatitis C, there are multiple factors that can negatively affect the quality of life of infected patients. The aim of this study was to evaluate changes in the health-related quality of life (HRQoL) in patients under second-generation direct-acting antiviral (DAA) (interferon-free) therapies and to assess treatment effectiveness. This was an observational study conducted in Curitiba (Brazil) using two instruments (a generic and a specific) for measuring the quality of life in patients with chronic hepatitis C, the Short Form-36 (SF-36) and the Chronic Liver Disease Questionnaire (CLDQ) for liver disease evaluation. Read More

View Article
November 2018
1 Read

Effectiveness of antiretroviral therapy in the single-tablet regimen era.

Rev Saude Publica 2018 Nov 14;52:87. Epub 2018 Nov 14.

Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduação em Saúde Pública. Belo Horizonte, MG, Brasil.

Objective: To evaluate the effectiveness of antiretroviral therapy and the associated factors according to the type of regimen used: Single Tablet Regimen or Multiple Tablet Regimen.

Methods: Prospective cohort of 440 patients (male, 74.3%, median age, 36 years old) who initiated antiretroviral therapy between Jan/14 and Dec/15 at a referral service in Belo Horizonte. Read More

View Article
November 2018
5 Reads

Light curing resin cements containing iodonium salts promote suitable apical bonding of posts to radicular dentin.

Braz Oral Res 2018 Nov 14;32:e116. Epub 2018 Nov 14.

Universidade Estadual de Campinas - Unicamp, Piracicaba Dental School, Department of Restorative Dentistry, Piracicaba, SP, Brazil.

The aim of this study was to analyze the efficiency of experimental light-curing resin cements (ERCs) with a ternary photo-initiator system containing diphenyliodonium hexafluorphosphate (DPI) and different amines on retention of glass-fiber posts to dentin (GFP). ERCs formulations: a 1:1 mass ratio of 2,2-bis[4-(2-hydroxy-3-methacryloxypropoxy)phenylpropane and triethyleneglycol dimethacrylate. Camphorquinone was used as initiator. Read More

View Article
November 2018
4 Reads

Impact of a change in duration of prophylactic antibiotics on infectious complications after radical cystectomy with a neobladder.

Medicine (Baltimore) 2018 Nov;97(47):e13196

Departments of Internal medicine.

A profound number of prophylactic antibiotics are used after radical cystectomy with an ileal orthotopic neobladder (RCIONB) despite a negative effect of infection control. We investigated the impact of short-term prophylactic antibiotic use on infectious complications after RCIONB.We retrospectively reviewed data from 287 patients who underwent RCIONB for bladder cancer between 2012 and 2016 at a tertiary hospital. Read More

View Article
November 2018

Cerebrospinal fluid rhinorrhea in a bilateral frontal decompressive craniectomy patient caused by strenuous activity: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13189

Department of Neurosurgery.

Rationale: Iatrogenic cerebrospinal fluid (CSF) rhinorrhea in a bilateral frontal decompressive craniectomy patient triggered by strenuous sport is rare. To the best of our knowledge, no similar case has yet been reported.

Patient Concerns: Herein, we report a case of CSF rhinorrhea in a 37-year-old man. Read More

View Article
November 2018
1 Read

Shutting Down Shigella Secretion: Characterizing Small Molecule Type Three Secretion System ATPase Inhibitors.

Biochemistry 2018 Nov 21. Epub 2018 Nov 21.

Many important human pathogens rely on one or more type three secretion systems (T3SS) to inject bacterial effector proteins directly into the host cell cytoplasm. Protein secretion through the needle-like type three secretion apparatus (T3SA) is essential for pathogen virulence and relies on a highly-conserved ATPase at the base of the apparatus, making it an attractive target for anti-infective therapeutics. Here, we leveraged the ability to purify an active oligomeric Shigella T3SS ATPase to provide kinetic analyses of three T3SS ATPase inhibitors of Spa47. Read More

View Article
November 2018
1 Read

Rheumatoid Arthritis-Associated Autoimmunity Due to and Its Resolution With Antibiotic Therapy.

Front Immunol 2018 16;9:2352. Epub 2018 Oct 16.

Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

() is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, has been recently linked to rheumatoid arthritis (RA) pathogenesis. Although mechanistic and clinical association studies implicate infection in the initiation of autoimmunity in RA, direct evidence in humans is lacking. Read More

View Article
October 2018
4 Reads

First trimester medication use in pregnancy in Cameroon: a multi-hospital survey.

BMC Pregnancy Childbirth 2018 Nov 20;18(1):450. Epub 2018 Nov 20.

Department of Nursing, School of Health Sciences, Biaka University Institute of Buea-Cameroon, PO BOX 77, Buea, Cameroon.

Background: There is a paucity of epidemiological data on medication use in pregnancy in Cameroon.

Methods: Between March and August 2015, 795 pregnant women attending 8 urban and 12 rural hospitals in Cameroon for antenatal (ANC) or other care were interviewed on first trimester medication use using structured questionnaires. Multivariate logistic regression was used to analyse the association of 18 sociodemographic factors with medication use. Read More

View Article
November 2018
1 Read

Preventing neonatal sepsis in rural Uganda: a cross-over study comparing the tolerance and acceptability of three alcohol-based hand rub formulations.

BMC Public Health 2018 Nov 20;18(1):1279. Epub 2018 Nov 20.

Sanyu Africa Research Institute (SAfRI), Mbale Regional Referral Hospital, Pallisa-Kumi Road Junction, P.o Box 2190, Mbale, Uganda.

Background: Neonatal sepsis causes 0.5 million deaths annually, mostly in low resource settings. Babies born in African rural homes without running water or toilet facilities are especially vulnerable. Read More

View Article
November 2018
2 Reads

Sulforaphane-N-Acetyl-Cysteine Induces Autophagy Through Activation of ERK1/2 in U87MG and U373MG Cells.

Cell Physiol Biochem 2018 20;51(2):528-542. Epub 2018 Nov 20.

Department of Human Anatomy, Hebei Medical University, Shijiazhuang,

Background/aims: Sulforaphane-N-acetyl-cysteine (SFN-NAC) is a sulforaphane (SFN) metabolite with a longer half-life and better blood-brain barrier permeability than those of SFN. Previous studies have found that SFN-NAC can act via ERK to destroy microtubules and inhibit cell growth in lung cancer cells. However, the underlying mechanisms are unclear, and it is unknown whether SFN-NAC can inhibit the growth of glioma. Read More

View Article
December 2018
3 Reads

Molecular analysis of Shiga toxin-producing Escherichia coli O157:H7 and non-O157 strains isolated from calves.

Onderstepoort J Vet Res 2018 Oct 17;85(1):e1-e7. Epub 2018 Oct 17.

Department of Medical Biotechnology, Fasa University of Medical Science, Iran; and, Department of Biology, Payame Noor University (PNU).

Shiga toxin-producing Escherichia coli (STEC) O157 and non-O157 are food-borne pathogens and contaminants of foods of animal origin. This study was conducted to investigate the presence of virulence and integrase genes in STEC isolates from diarrhoeic calves in Fars Province, Iran. Five hundred and forty diarrheic neonatal calves were randomly selected for sampling. Read More

View Article
October 2018
4 Reads

The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis.

APMIS 2018 Dec;126(12):885-891

Cystic Fibrosis Center Copenhagen, Rigshospitalet, Copenhagen, Denmark.

Mycobacterium abscessus complex can cause severe lung infections and has proven to be a serious threat to patients with cystic fibrosis and a challenge for clinicians due to difficulties in timely diagnosis and complex multidrug treatment regimes. Mycobacterial culture is the gold standard for diagnosis, but in most cystic fibrosis centers it is performed less frequently than culture for other pathogens. Consensus today recommends just one annual mycobacterial culture for asymptomatic patients with cystic fibrosis, a strategy likely to lead to diagnostic delays. Read More

View Article
December 2018
3 Reads

ATMT transformation efficiencies with native promoters in Botryosphaeria kuwatsukai causing ring rot disease in pear.

World J Microbiol Biotechnol 2018 Nov 19;34(12):179. Epub 2018 Nov 19.

Departmental of Health Sciences, Faculty of Science, University of Mauritius, Reduit, 80837, Mauritius.

Botryosphaeria kuwatsukai is an important fungal pathogen affecting pear fruits. However, infection processes of this fungus are still unclear. This study seeks to develop the fungal transformation of B. Read More

View Article
November 2018
3 Reads

Comparative activity of ciprofloxacin and levofloxacin against isolated uropathogens in Ghana: a pilot study.

Pan Afr Med J 2018 5;30:194. Epub 2018 Jul 5.

Ghana Police Hospital, Pharmacy Department, Accra, Ghana.

Introduction: Studies on urinary tract infections (UTIs) in West Africa from 1990 to 2012 have showed moderate to high antimicrobial resistance to commonly prescribed antibiotics. Fluoroquinolones have been the main stay in the management of UTIs, but recent reports show emergence of resistance. Levofloxacin and ciprofloxacin still remain the commonest fluoroquinolones prescribed for UTIs in many settings. Read More

View Article
December 2018
3 Reads

[Evaluation of surgical antibiotic prophylaxis in a Tunisian University Hospital].

Pan Afr Med J 2018 2;30:191. Epub 2018 Jul 2.

Direction Régionale de la Santé, Kairouan, Tunisie.

Antibiotic prophylaxis (ATBP) is one of the specific measures for the prevention of surgical site infections, whose impact has been quantified in clean or clean-contaminated surgery. Our study aims to evaluate the conformity of ATBP practices and the adherence to the prescribing protocols adopted in our Hospital. We conducted a clinical audit retrospective observational study, evaluating antibiotic prophylaxis practices in our Hospital in the month of March 2015. Read More

View Article
December 2018
5 Reads
  • Page 1 of 32034