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    1512 results match your criteria Anti-Cancer Agents in Medicinal Chemistry[Journal]

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    Design, synthesis and biological evaluation of novel urea and thiourea bearing thieno[3,2-d]-pyrimidines as PI3 kinase inhibitors.
    Anticancer Agents Med Chem 2018 Feb 9. Epub 2018 Feb 9.
    University of Hyderabad - Department of Animal Biology Hyderabad, Telangana. India.
    Phosphatidylinositol-3-kinase α (PI3Kα) is a ubiquitous intracellular enzyme, mainly involved in intracellular signaling pathways, promotes cellular growth, proliferation, and differentiation. Therefore, inhibition of PI3K can be a hotspot in molecular targeted therapy for the treatment of cancer. The present research work involves molecular docking studies performed to screen derivatives of urea and thiourea bearing thieno [3,2-d]-pyrimidines against the active site of PI3K enzyme using MOE. Read More

    Reserpine induces apoptosis and cell cycle arrest in hormone independent prostate cancer cells through mitochondrial membrane potential failure.
    Anticancer Agents Med Chem 2018 Feb 9. Epub 2018 Feb 9.
    Madurai Kamaraj University - Biotechnology Madurai, Tamilnadu. India.
    Reserpine, an indole alkaloid commonly used for hypertension, is found in the roots of Rauwolfia serpentina. Although the root extract has been used for the treatment of cancer, the molecular mechanism of its anti-cancer activity on hormonal independent prostate cancer remains elusive. Therefore, we evaluated the cytotoxicity of reserpine and other indole alkaloids, yohimbine and ajmaline on prostate cancer cells (PC3) using MTT assay. Read More

    Caffeine inhibits angiogenesis in human glioblastoma cells via HIFs modulation.
    Anticancer Agents Med Chem 2018 Feb 9. Epub 2018 Feb 9.
    Biomedical and Biotechnological Science Catania. Italy.
    Caffeine represents the most used psychoactive drug in the world acting as a non-selective adenosine receptor antagonist. It exerts an anti-cancer role in glioblastoma multiforme (GBM). This neoplasia is characterized by extensive hypoxic foci triggering hypoxia-inducible factors (HIFs) expression. Read More

    Investigating the therapeutic effects of alginate nanogel co-loaded with gold nanoparticles and cisplatin on U87-MG human glioblastoma cells.
    Anticancer Agents Med Chem 2018 Jan 30. Epub 2018 Jan 30.
    Iran Univ. of Med. Sci. Iran.
    Background And Purpose: It has been well-known both gold nanoparticles (AuNPs) and cisplatin are potential radiosensitizers for radiotherapy of cancer. In this in vitro study, we investigated the chemo-radiotherapeutic effects of alginate nanogel co-loaded with AuNPs and cisplatin (ACA) on U87-MG human glioblastoma cells.

    Methods: Based on the accomplished pilot studies, U87-MG cells were incubated with ACA and cisplatin at 10% inhibitory concentration (IC10) for 4 h. Read More

    Potential Pharmacological Inhibitors Of Pim Kinase Under Clinical Trials.
    Anticancer Agents Med Chem 2018 Jan 30. Epub 2018 Jan 30.
    JSS College of Pharmacy - Director, TIFAC core Ootacamund, Tamilnadu. India.
    Pim kinases, also known as Serine/Threonine kinases, are intensively studied protein drug targets in cancer research. They play crucial role in the regulation of signal transduction cascades that promote cell survival, proliferation and drug resistance. Pim kinases are overexpressed in several hematopoietic and solid tumors and support in vitro/in vivo malignant cell growth and survival, through cell cycle regulation and inhibition of apoptosis. Read More

    Melatonin differentially modulates NF-КB expression in breast and liver cancer cells.
    Anticancer Agents Med Chem 2018 Jan 30. Epub 2018 Jan 30.
    Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP Laboratorio de Investigacao Molecular do Cancer - LIMC. Brazil.
    Background NF-kB (nuclear factor kappa B) is a transcription factor composed of two subunits, p50 and p65, which plays a key role in the inflammatory process. Melatonin has oncostatic, antiangiogenic and antimetastatic properties, and some recent studies have indicated an inhibitory effect of melatonin on NF-kB in some types of cancer. This work aims to investigate the effects of melatonin treatment on the expression of NF-kB in breast and liver cancer models. Read More

    Anticancer activity study of Chromone and Coumarin hybrids using electrical impedance spectroscopy.
    Anticancer Agents Med Chem 2018 Jan 29. Epub 2018 Jan 29.
    Ecole Nationale Polytechnique. Algeria.
    Oncology treatments aim at selective toxicity for tumor (compared to normal) cells, and chromone-coumarin hybrids have shown such activity. In this study, we test a novel series of synthetic chromone and coumarin derivatives (1-9) for cytotoxic activity against a panel of tumor cell lines (MCF-7, A549, HepG2, HTC-116, B16) opposed to non-tumor cells (Caco-2 and HEK-293t). Electrical impedance spectroscopy was used to monitor cell viability in real time. Read More

    HPLC analysis of phenolic acids, antioxidant activity and in vitro effectiveness of green and roasted Caffea arabica bean extracts: a comparative study.
    Anticancer Agents Med Chem 2018 Jan 24. Epub 2018 Jan 24.
    Faculty of Science, Menoufia University, Menoufia. Egypt.
    Coffee is a popular drink; it is one of the most commercialized food products and a rich source of biologically active compounds that are important for human health. This study aimed to prove the anticancer activity of green coffee (GC) and roasted coffee (RC) bean aqueous extracts (Coffea arabica) on breast cancer adenocarcinoma cell line (MCF-7) and the safety of both extracts on normal human peripheral blood lymphocytes culture (HPBL). Total phenolic content for GC and RC extracts was measured and result of both extracts were (0. Read More

    Synthesis of Novel Thieno[2,3-d]pyrimidine Derivatives and Evaluation of Their Cytotoxicity and EGFR Inhibitory Activity.
    Anticancer Agents Med Chem 2018 01 24. Epub 2018 Jan 24.
    Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
    Novel 4-substitutedaminothieno[2,3-d]pyrimidine derivatives 4a-i and 5a-c were synthesized via reacting corresponding 4-chlorothieno[2,3-d]pyrimidine derivatives 3a-c with N-methylpiperazine, morpholine, N-phenylpiperazine or 1,3-propanediamine. All of the newly synthesized compounds were submitted to the National Cancer Institute (USA) for anticancer evaluation. Six compounds (2a, 4d, 4e, 5a-c) were selected and evaluated using 60 different human tumor cell lines using a single dose (10-5 Molar). Read More

    Design, Synthesis, and Biological Evaluation of New Azole Derivatives as Potent Aromatase Inhibitors with Potential Effects against Breast Cancer.
    Anticancer Agents Med Chem 2018 Jan 15. Epub 2018 Jan 15.
    Mashhad university of medical sciences - school of pharmacy Mashhad. Iran.
    Purpose: Some aromatase inhibitors are FDA-approved agents as first-line therapy in the treatment of endocrine-responsive breast cancer. In this study, we aimed to develop new azole derivatives with higher specificity and potency.

    Methods: New aromatase inhibitors were designed by Molecular Operating Environment (MOE) software and synthesized in a one-step SN2 reaction. Read More

    Nanoemulsion strategy for ursolic and oleanic acids isolates from Plumeria obtusa improves antioxidant and cytotoxic activity in melanoma cells.
    Anticancer Agents Med Chem 2018 Jan 11. Epub 2018 Jan 11.
    University of Barcelona - Nanoscience and Nanotechnology Institute (IN2UB) Barcelona, Morelos. Spain.
    Background: Triterpenoids are an important class of natural bioactive products present in many medicinal plants.

    Objective: The aim of present study is to investigate the antioxidant and anticarcinogenic potential of oleanolic acid (OA) and ursolic acid (UA) on B16 murine melanoma cell line isolated from Plumeria obtusa, free and loaded in a nanoemulsion (NEm) system.

    Method: The nanoemulsion was characterized by dynamic light scattering, transmission electron microscopy. Read More

    Inhibition of migration and invasion of hepatocarcinoma HepG2 cells by dietary saponins via targeting HIF-1α.
    Anticancer Agents Med Chem 2018 01 10. Epub 2018 Jan 10.
    Zheiang Ocean University - Faculty of Food and Pharmacy, Zhoushan. China
    Different saponins from herbs have been used as tonic or functional foods, and for treatment of various diseases including cancers. Although clinical data has supported the function of these saponins, their underlying molecular mechanisms have not been well defined. With the simulated hypoxia created by 8 hours of Cu++ exposure and following 24 hour incubation with different concentration of saponins in HepG2 cells, ZC-4 had the highest rate of inhibition of cell proliferation by MTT assay, and the highest inhibition of migration rate by in vitro scratch assay, while ZC-3 had the highest inhibition of invasion ratio by transwell assay. Read More

    Algerian Propolis Potentiates Doxorubicin Mediated Anticancer Effect against Human Pancreatic PANC-1 Cancer Cell Line through Cell Cycle Arrest, Apoptosis Induction and P-Glycoprotein Inhibition.
    Anticancer Agents Med Chem 2018 Jan 10. Epub 2018 Jan 10.
    Laboratory of pharmacology, Faculty of medicine, University of Jordan, Amman. Jordan.
    Background: Pancreatic cancer is one of the most aggressive and lethal cancer, with poor prognosis and high resistant to current chemotherapeutic agents. Therefore, new therapeutic strategies and targets are underscored. Propolis has been reported to exhibit a broad spectrum of biological activities including anticancer activity. Read More

    Amygdalin, from Apricot Kernels, Induces Apoptosis and Causes Cell Cycle Arrest in Cancer Cells: An Updated Review.
    Anticancer Agents Med Chem 2018 Jan 5. Epub 2018 Jan 5.
    Government College University Faisalabad. Pakistan.
    Amygdalin is a cyanogenic glycoside which is described as a naturally occurring anti-cancer agent. In 1830s, French chemists Robiquet and Boutron-Charlard isolated amygdalin from bitter almonds. Apoptosis is an important mechanism in cancer treatment by amygdalin. Read More

    The clinical and experimental research on the treatment of endometriosis with thiostrepton.
    Anticancer Agents Med Chem 2018 Jan 7. Epub 2018 Jan 7.
    Laboratory for Reproductive Health, Shenzhen Institute of Advanced Technology - Chinese Academy of Sciences shenzhen. China.
    Background/objective: Forkhead Box M1 (FOXM1) is frequently activated in tumors. We studied the expression and the possible mechanism of FOXM1 and evaluated the effects of thiostrepton in an endometriotic rat model.

    Study Design: This was a randomized study in a rat model of endometriosis. Read More

    Polyphyllin I Induces Cell Cycle Arrest and Cell Apoptosis in Human Retinoblastoma Y-79 Cells through Targeting p53.
    Anticancer Agents Med Chem 2018 Jan 7. Epub 2018 Jan 7.
    University of Sydney - Save Sight Institute Sydney. Australia.
    Retinoblastoma is the most common intraocular malignant tumor in childhood. Although external beam radiation and enucleation are effective to control retinoblastoma, eye salvage and vision preservation are still significant challenges. Polyphyllin I (PPI), a natural compound extracted from Paris polyphylla rhizomes, has a wide range of activities against many types of cancers. Read More

    Synthesis and Evaluation of Heterocycles Based Chalcone Derivatives as Antiproliferative Agents.
    Anticancer Agents Med Chem 2018 Jan 5. Epub 2018 Jan 5.
    Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470 Eskisehir. Turkey.
    A series of novel chalcone derivatives bearing diverse heterocycles have been synthesized and evaluated for their antiproliferative activity against A549 (human lung adenocarcinoma) and C6 (rat brain glioma) cells. Structures of the title compounds (3-18) were verified by FT-IR, 1H NMR, 13C NMR, HRMS spectral data and elemental analyses. Antiproliferative activities of the compounds were evaluated using MTT assay, BrdU method, and flow cytometric analysis. Read More

    Edelfosine: an antitumor drug prototype.
    Anticancer Agents Med Chem 2018 Jan 5. Epub 2018 Jan 5.
    Institute of Biomedical Sciences of University of Sao Paulo, Sao Paulo - Department of Immunology Sao Paulo, Sao Paulo. Brazil.
    Lung cancer is the most prevalent cancer and a high fatality disease. Despite all therapeutic approaches available, drug resistance and excessively toxic effects of chemotherapy agents for patients remain as obstacles. Therefore, we proposed the design of new drugs integrating immunotherapeutic and conventional cytotoxic effects as a powerful strategy in the treatment of cancer. Read More

    Latest Evidence On The Role Of Multiparametric Magnetic Resonance Imaging In Active Surveillance For Insignificant Prostate Cancer: A Systematic Review.
    Anticancer Agents Med Chem 2018 Jan 4. Epub 2018 Jan 4.
    Department of Urology, University Magna Graecia of Catanzaro, Catanzaro. Italy.
    Objective: Multiparametric Magnetic Resonance Imaging (mpMRI) has become a very useful tool in the management of low risk Prostate Cancer (PCa) patients eligible for Active Surveillance (AS). The aim of this systematic review was to critically review the latest literature concerning the role of mpMRI in this clinical setting, underlying current strengths and weakness.

    Evidence Acquisition: A comprehensive literature research for English-language original and review articles was carried out using the National Center for Biotechnology Information PubMed database with the aim of identify studies on mpMRI for AS in low risk PCa patients. Read More

    Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review.
    Anticancer Agents Med Chem 2017 Dec 29. Epub 2017 Dec 29.
    Central University of Punjab - Centre for Pharmaceutical Sciences and Natural Products Bathinda, Punjab. India.
    In worldwide lung cancer shares 14% among the newly diagnosed cancer cases. Currently, the numbers of drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect. Read More

    Pre-Clinical Validation of Mito-Targeted Nano-Engineered Flavonoids Isolated From Selaginella bryopteris (Sanjeevani) As A Novel Cancer Prevention Strategy.
    Anticancer Agents Med Chem 2017 Dec 29. Epub 2017 Dec 29.
    Background: Novel bioactive plant secondary metabolites, including flavonoids, offer a spectrum of chemo-protective responses against a range of human tumor models. However, the clinical translation of these promising anti-cancer agents has been hindered largely by their poor solubility, rapid metabolism, or a combination of both, ultimately resulting in poor bioavailability upon oral administration.

    Objective: To circumvent the challenges associated with herbal drug development and for effective integration into clinical setting, nano-engineering is one of the emerging pragmatic strategy which has promise to deliver therapeutic concentrations of bio-actives upon oral administration. Read More

    Fisetin Attenuates AKT Associated Growth Promoting Events in AflatoxinB1 Induced Hepatocellular Carcinoma.
    Anticancer Agents Med Chem 2017 Dec 29. Epub 2017 Dec 29.
    Biochemistry Section, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi-221005. India.
    Recently we have reported that Fisetin, a natural flavonol, is able to regress Aflatoxin-B1 (AFB1) induced hepatocellular carcinoma (HCC) by suppressing reactive oxygen species (ROS) led pro-inflammatory factors in rats. In the current study, we aimed to delineate whether Fisetin does so by modulating the cell growth promoting signaling cascade in HCC. The reciprocal interplay of 3-phosphoinositol kinase (PI3K) vs phosphatase and tensin homologue deleted on chromosome 10 (PTEN) displays Akt, a protein kinase B, to get phosphorylated at Thr308 by a 3-phosphoinositol dependent kinase 1 (PDK1). Read More

    Determination of the apoptotic effect and molecular docking of benzamide derivative XT5 in K562 cells.
    Anticancer Agents Med Chem 2017 Dec 29. Epub 2017 Dec 29.
    School of Medicine, Ankara University - Department of Medical Biology Ankara. Turkey.
    Background: The tyrosine kinase inhibitor imatinib used as a first line treatment in chronic myeloid leukemia (CML) patients, may lead to resistance and failure to therapy. Novel combinations of imatinib with other drugs is a strategy to improve treatment efficiency.

    Objective: In this study, the antileukemic and apoptotic effects of a benzamide derivative XT5 and benzoxazole derivative XT2B and their combination with imatinib were investigated in imatinib-sensitive (K562S) and imatinib-resistant (K562R) CML cells. Read More

    Synthesis and biological evaluation of novel triazoles linked 7-hydroxycoumarin as potent cytotoxic agents.
    Anticancer Agents Med Chem 2017 12 29. Epub 2017 Dec 29.
    Bioorganic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal road Jammu -180001, J&K, India
    Cancer is regarded as second leading cause of death worldwide. Therefore, there is a high demand for the discovery, development and improvement of novel anti-cancer agents which could efficiently prevent proliferative pathways and clonal expansion of cells. In view of this, a new series of bioactive scaffolds viz triazoles linked 7-hydroxycoumarin (1) were synthesized using click chemistry approach. Read More

    Astragalin attenuates UVB radiation-induced Actinic Keratosis formation.
    Anticancer Agents Med Chem 2017 Dec 29. Epub 2017 Dec 29.
    Affiliated Hospital of Yan'an University Yan'an. China.
    Actinic keratosis (AK), is the most common precancerous skin lesion induced by the excessive ultraviolet B (UVB) and is a significant threat to the public health. UVB exposure causes oxidative DNA damage and is considered to be a significant contributor to AK and subsequent development of skin cancer. Besides, activation of p38 MAPK also plays a significant role in the development of AK. Read More

    Translational Research in Cutaneous Melanoma: New Therapeutic Perspectives.
    Anticancer Agents Med Chem 2017 Dec 18. Epub 2017 Dec 18.
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114. United States.
    Melanoma is an aggressive form of skin cancer characterized by poor prognosis and high mortality. The development of targeted agents based on the discovery of driver mutations as well as the implementation of checkpoint inhibitor-based immunotherapy represent a major breakthrough in the treatment of metastatic melanoma. However, in both cases the development of drug resistance and immune escape mechanisms as well as the lack of predictive biomarkers limit their extraordinary clinical efficacy. Read More

    Synthesis, spectral characterization, antibacterial and anticancer activity of some titanium complexes.
    Anticancer Agents Med Chem 2017 Dec 19. Epub 2017 Dec 19.
    Guru Nanak Dev University, Amritsar, Punjab - Department of Botanical and Environmental Sciences Amritsar, punjab. India.
    Titanium complexes with and without labile groups have been synthesized by the reaction of titanium tetrachloride (TiCl4) with N- containing ligands (1,2-diaminocyclohexane (dach), 1,10-Phenanthroline (phen) and adamantylamine (ada), 2,2'-bipyridine (bipy), 4,4'-dimethyl-2,2'-bipyridine (bpme)) in 1:2 and 1:2:2 molar ratio respectively. The synthesized complexes have been characterized by different spectroscopic techniques i.e. Read More

    Emodin enhances the chemosensitivity of endometrial cancer by inhibiting ROS-mediated Cisplatin-resistance.
    Anticancer Agents Med Chem 2017 Dec 18. Epub 2017 Dec 18.
    QiLu Hospital of Shandong University - Department of Obstetrics and Gynecology Jinan. China.
    Background Endometrial cancer is a common cause of death in gynecological malignancies. Cisplatin is a clinically chemotherapeutic agent. However, drug-resistance is the primary cause of treatment failure. Read More

    A Cell cycle arrest and Apoptosis induction of Phloroacetophenone Glycosides and Caffeoylquinic Acid Derivatives in Gastric Adenocarcinoma (AGS) Cells.
    Anticancer Agents Med Chem 2017 12 19. Epub 2017 Dec 19.
    Faculty of Pharmacy, Tehran University of Medical Sciences. Iran.
    In the present study, we analyzed anti-proliferative and apoptosis induction activity of five phenolic compounds: echisoside, pleoside, chlorogenic acid, 4,5-Di-O-caffeoylquinic acid, and cynarin on AGS (adenocarcinoma gastric) cell line. These phenolic compounds were isolated from methanol extract of Dorema glabrum root. An MTT assay was conducted to evaluate the inhibitory effect on cancer cells. Read More

    Anticancer Activity of Resorcinarene-PAMAM-Dendrimer Conjugates of Flutamide.
    Anticancer Agents Med Chem 2017 Dec 18. Epub 2017 Dec 18.
    Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Circuito Exterior, Coyoacan, C.P. 04510, Mexico City. Mexico.
    The synthesis of conjugates of flutamide with resorcinarene-PAMAM-dendrimers as well as alkyl and ethyl phenyl chains in the lower part of the macrocycle as a nucleus and diethylenetriamines in the dendritic branches gives the opportunity to obtain conjugates in one step of synthesis with 16 and 64 flutamide moieties in the structure. The in vitro anticancer studies showed that the conjugates of flutamide are more active than the free flutamide and the flutamide derivatives, thus diminishing the amount of flutamide used. The resorcinarene-dendrimer-flutamide conjugates with a high drug payload improve the activity of the drug. Read More

    ROS-scavenging and anti-tyrosinase properties of crocetin on B16F10 murine melanoma cells.
    Anticancer Agents Med Chem 2017 Dec 13. Epub 2017 Dec 13.
    Mashhad University of Medical Sciences. Iran.
    Background: Crocus sativus (Iridaceae) has been traditionally used in the Iranian folk medicine and as a culinary additive. Major components of the plant that are responsible for biological properties are saffranal, crocin, picrocrocin and crocetin. Although the level of crocetin is not high, some of the important activities of saffron such as antioxidant activity have been attributed to crocetin. Read More

    The effect of flubendazole on adhesion and migration in SW480 and SW620 colon cancer cells.
    Anticancer Agents Med Chem 2017 Dec 13. Epub 2017 Dec 13.
    Department of Biochemical SciencesCharles University in Prague, Faculty of PharmacyHeyrovskeho 1203Hradec Kralove, CZ-500 05. Czech Republic.
    Colon cancer is the most common type of gastrointestinal cancer. Despite advances during the last two decades, the efficacy of colorectal cancer treatment is still insufficient and new anticancer agents are necessary. In our study, colon cancer cells derived from a primary tumor (SW480) and lymph node metastasis (SW620) from the same patient were used and compared. Read More

    Inhibition of intercellular communication between prostate cancer cells by a specific anti-STEAP-1 single chain antibody.
    Anticancer Agents Med Chem 2017 Dec 7. Epub 2017 Dec 7.
    Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.
    Background: Six-Transmembrane epithelial antigen of the prostate-1 (STEAP-1) is present at the intercellular junctions of the secretory epithelium of prostate and is overexpressed in all steps of prostate cancer. STEAP-1 acts as a transporter protein or a putative channel between cancer cells while it has limited expression in normal human tissues. This protein has been suggested as an attractive target for prostate cancer immunotherapy. Read More

    A Newly Synthetized Ferrocenyl Derivative Selectively Induces Apoptosis in ALL Lymphocytes through Mitochondrial Estrogen Receptors.
    Anticancer Agents Med Chem 2017 Dec 5. Epub 2017 Dec 5.
    ShahidBeheshti University of Medical Sciences, Tehran. Iran.
    Background: Estrogens, as the main female steroid hormones have multiple proven effects on reproductive and non- reproductive systems. Expression of ERα and ERβ, two dominant estrogen receptors, in peripheral blood mononuclear cells in certain B-cell malignancies and the existence of estrogens receptors on mitochondria is open to question that estrogen likely has an impact on the cancerous lymphocytes life span. Acute lymphoblastic leukemia (ALL) is the frequent pediatric malignity which is recurrent and hardly curable in many cases. Read More

    Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents.
    Anticancer Agents Med Chem 2017 Dec 5. Epub 2017 Dec 5.
    Anadolu University Faculty of Pharmacy - Department of Pharmaceutical Chemistry Eskisehir. Turkey.
    Background: Arylidene indanones have attracted a great deal of interest due to their outstanding therapeutic applications. In particular, considerable research has pointed out the importance of arylidene indanones in the field of cancer research.

    Objective: The aim of the current work was to design and synthesize arylidene indanone-based anticancer agents. Read More

    Design, Synthesis and Cytotoxicity Evaluation of New 3, 5-Disubstituted-2-Thioxoimidazolidinones.
    Anticancer Agents Med Chem 2017 Nov 29. Epub 2017 Nov 29.
    Kafrelsheikh University, Kafrelsheikh. Egypt.
    Background Some 2-thioxoimidazolidinones have been reported as anti-prostate and anti-breast cancer agents through their inhibitory activity on topoisomerase I that is considered as a potential chemotherapeutic target. Objective A new series of 3,5-disubstituted-2-thioxoimidazolidinone derivatives 10a-f and their S-methyl analogs 11a-f were designed, synthesized and evaluated for cytotoxicity against human prostate cancer cell line (PC-3), human breast cancer cell line (MCF-7) and non-cancerous human lung fibroblast cell line (WI-38). Results and Method While compounds 10a-f showed a broad range of activities against PC-3 and MCF-7 cell lines (IC50 = 34. Read More

    Good fashion is evolution, not revolution" - methods to enhance existing anticancer medicines, primarily with use of transition metal.
    Anticancer Agents Med Chem 2017 11 29. Epub 2017 Nov 29.
    Bialystok University of Technology - Division of Chemistry, Faculty of Civil Engineering and Environmental Engineering Bialystok. Poland.
    The constant search for a successful cancer therapies lasts for decades. Apart from the huge scientific effort and enormous sum of spent money, only a small amount of newly developed medicines move into clinical use (only 94 registered anticancer drugs in the last 12 years [1]). Anticancer regimes are still overcome by drugs invented over 50 years ago such as cisplatin and doxorubicin. Read More

    Design, Synthesis and Anti-breast Cancer activity of Some Novel substituted Isoxazoles as Anti-breast Cancer Agent.
    Anticancer Agents Med Chem 2017 Nov 29. Epub 2017 Nov 29.
    Y.B. Chavan College of Pharmacy - Pharm Chemistry Aurangabad, maharashtra. India.
    A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has ability to inhibit the growth of the human breast cancer cell line at low concentrations. In-vivo anticancer activity was performed on virgin female sprague dawley rats. Read More

    Computational study of the binding modes of diverse DPN analogues on estrogen receptors (ER) and the biological evaluation of a new potential antiestrogenic ligand.
    Anticancer Agents Med Chem 2017 11 29. Epub 2017 Nov 29.
    Laboratorio de Modelado Molecular, Bioinformática y diseño de fármacos. Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional. Plan de San Luis y Díaz Mirón S/N, Col. Casco de Santo Tomas, Mexico City, 11340 MX
    Estrogen (17β-estradiol) is essential for normal growth and differentiation in the mammary gland. In the last three decades previous investigations have revealed that estrogen receptor alpha (ERα) plays a critical role in breast cancer. More recently, observations regarding the widespread expression of ERβ-like proteins in normal and neoplastic mammary tissues have suggested that ERβ is also involved in the mentioned pathology. Read More

    Trichinella spiralis and tumors: cause, coincidence or treatment?
    Anticancer Agents Med Chem 2017 Nov 20. Epub 2017 Nov 20.
    Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun. China.
    Conventional therapeutic strategies for tumors have had limited success, and innovative and more effective approaches to treatment are urgently required. The ancient idea that various biological, bacterial, yeast, viral, and parasitic agents can be used as cancer therapeutics has gradually attracted considerable interest. Certain parasites have been widely discussed in association with human and animal tumors. Read More

    Comparison of Physicochemical Properties of Generic Doxorubicin HCl Liposome Injection with the Reference Listed Drug.
    Anticancer Agents Med Chem 2017 Nov 21. Epub 2017 Nov 21.
    Sun Pharmaceutical Industries Ltd. Mumbai. India.
    Background: Liposomal doxorubicin is widely used for treating ovarian cancer and Kaposi's sarcoma. Encapsulation of doxorubicin in highly complex polyethylene glycol-coated (stealth) liposomes prolongs residence time and avoids the systemic toxicity associated with administration of the free drug. Small variations in physicochemical properties introduced during manufacture of liposomes can influence the payload of encapsulated drug, stability of liposomes under physiological conditions, and release of drug at the target tissue. Read More

    A Review on Melatonin’s Effects in Cancer: Potential Mechanisms
    Anticancer Agents Med Chem 2017 11 21. Epub 2017 Nov 21.
    Acibadem University School of Medicine, Istanbul. Turkey.
    This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved molecule; it is also an antioxidant and an impressive protector of mitochondrial bioenergetic activity. MLT is characterized by an ample range of activities, modulating the physiology and molecular biology of the cell. Read More

    Natural Compounds in the Chemoprevention of Malignant Melanoma.
    Anticancer Agents Med Chem 2017 Nov 21. Epub 2017 Nov 21.
    "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara. Romania.
    Malignant melanoma is a very aggressive form of skin cancer, with increasing rates every year, with an etiology that derives from the transformation and uncontrolled growth of melanocytes. There are several treatment options which can be used as unique treatment or combined, depending upon the stage of melanoma including surgical excision, chemotherapy, immunotherapy, targeted therapy. Plant Kingdom displays an unequalled potential for the synthesis of highly diversified chemical structures. Read More

    A comparison of fucoidan conjugated to paclitaxel and curcumin for the dual delivery of cancer therapeutic agents.
    Anticancer Agents Med Chem 2017 Nov 21. Epub 2017 Nov 21.
    Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University - Ho Chi Minh City. Viet Nam.
    The aim of this study was to develop and compare polymeric micelles of fucoidan, a sulfated polysaccharide, and hydrophobic drugs such as paclitaxel and curcumin. Paclitaxel and curcumin are both known for their medicinal properties, including anticancer efficacy. However, their very low water solubility, absorption and rapid metabolism leads to reduced bioavailability. Read More

    Radio-Modulatory Potential ofCaffeic Acid Phenethyl Ester: A Therapeutic Perspective.
    Anticancer Agents Med Chem 2017 Nov 13. Epub 2017 Nov 13.
    Radiation and Cancer Therapeutics Lab, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067. India.
    Use of natural agents is an upcoming area of research in cancer biology. Caffeic acid phenethyl ester has received great attention because of its therapeutic potential in various conditions including cancer. It is an active/abundant component of propolis. Read More

    A review on the management of small renal masses: active surveillance versus surgery.
    Anticancer Agents Med Chem 2017 Nov 13. Epub 2017 Nov 13.
    Department of Urology, San Giovanni Battista Hospital, Citta della Salute e della Scienza, University of Turin, Turin. Italy.
    Despite the rise of small renal tumour (SRMs) diagnosis and related surgeries, death rate of kidney cancer is increasing, suggesting a non-optimal management of SRMs. Active Surveillance (AS) for kidney cancer was introduced to face this paradox. However, incertitude remains on whether and when AS can replace surgery in selected patients. Read More

    Ganoderma lucidum Polysaccharides as An Anti-cancer Agent.
    Anticancer Agents Med Chem 2017 Nov 13. Epub 2017 Nov 13.
    Louisiana State University Health Sciences Center, Shreveport, LA. United States.
    The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity. Clinical studies have shown beneficial effects of G. Read More

    A review of electroporation-based antitumor skin therapies and investigation of betulinic acid-loaded ointment.
    Anticancer Agents Med Chem 2017 Nov 13. Epub 2017 Nov 13.
    Department of Pharmaceutical Technology - University of Szeged, Szeged, H-6720. Hungary.
    Background: Electrochemotherapy is a novel treatment for cutaneous and subcutaneous tumors utilizing the combination of electroporation and chemotherapeutic agents. Since tumors have an increasing incidence nowadays as a result of environmental and genetic factors, electrochemotherapy could be a promising treatment for cancer patients.

    Objective: The aim of this article is to summarize the novel knowledge about the use of electroporation for antitumor treatments and to present a new application of electrochemotherapy with a well-known plant derived antitumor drug betulinic acid. Read More

    Steroidal anticancer agents: an overview of estradiol-related compounds.
    Anticancer Agents Med Chem 2017 Nov 13. Epub 2017 Nov 13.
    Faculty of Pharmacy, University of Szeged, Szeged, Hungary - Department of Pharmacodynamics and Biopharmacy Szeged. Hungary.
    Research of steroidal compounds as anticancer agents started almost 50 years ago. During the past decades several innovative new steroids, like cyproterone, finasteride, estramustin, exemestane and fulvestrant have successfully become part of routine clinical practice. Meanwhile, a vast amount of new information have accumulated about the functions of the endogenous steroid system (including the characterization of enzymes, receptors, transcription pathways, etc. Read More

    Growth kinetics and oncologic outcomes for small renal masses managed with active surveillance: a review of the literature.
    Anticancer Agents Med Chem 2017 Nov 13. Epub 2017 Nov 13.
    Division of Urology, Department of Surgery, MD Anderson Cancer Center at Cooper, Cooper Medical School of Rowan University, Camden, NJ. United States.
    An increasing number of enhancing renal masses are being discovered incidentally on cross-sectional imaging. Many can be characterized as small renal masses (SRMs), the natural history of which is heterogeneous and poorly understood. Active surveillance has been proposed as an initial management strategy for these tumors, particularly in the old and infirmed patient population. Read More

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