Design, synthesis and biological evaluation of novel urea and thiourea bearing thieno[3,2-d]-pyrimidines as PI3 kinase inhibitors.
- Naresh Varma Seelam,
- Srinu Bodige,
- Parameshwar Ravula,
- Kali Charan Gulipalli,
- Srinivas Endoori,
- J N Narendra Sharath Chandra,
- Purna Koteswara Rao Cherukumalli,
- G R Vanaja
Anticancer Agents Med Chem 2018 Feb 9. Epub 2018 Feb 9.
University of Hyderabad - Department of Animal Biology Hyderabad, Telangana. India.
Phosphatidylinositol-3-kinase α (PI3Kα) is a ubiquitous intracellular enzyme, mainly involved in intracellular signaling pathways, promotes cellular growth, proliferation, and differentiation. Therefore, inhibition of PI3K can be a hotspot in molecular targeted therapy for the treatment of cancer. The present research work involves molecular docking studies performed to screen derivatives of urea and thiourea bearing thieno [3,2-d]-pyrimidines against the active site of PI3K enzyme using MOE. Read More