7,985 results match your criteria Anthrax

Spectroscopic and microscopic characterization of dipicolinic acid and its salt photoproducts - A UVc effect study on DPA in solution and in bacterial spores.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 17;280:121502. Epub 2022 Jun 17.

UMR Procédés Alimentaires et Microbiologiques, L'Institut Agro Dijon, Université de Bourgogne Franche-Comté, 1, Esplanade Erasme, 21000 Dijon, France; Dimacell Imaging Facility, L'Institut Agro Dijon, Université de Bourgogne Franche-Comté, 1 Esplanade Erasme, 21000 Dijon, France. Electronic address:

Bacterial spores can cause significant problems such as food poisoning (like neurotoxin or emetic toxin) or serious illnesses (like anthrax or botulism). This dormant form of bacteria, made of several layers of barriers which provide extreme resistance to many abiotic stresses (radiation, temperature, pressure, etc.), are difficult to investigate in situ. Read More

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What Is Anthrax?

Pathogens 2022 Jun 16;11(6). Epub 2022 Jun 16.

Bacterial Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

Anthrax has been feared for its high mortality in animals and humans for centuries. The etiologic agent is considered a potentially devastating bioweapon, and since 1876-when Robert Koch demonstrated that Bacillus anthracis caused anthrax-it has been considered the sole cause of the disease. Anthrax is, however, a toxin-mediated disease. Read More

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An Outbreak of Human Systemic Anthrax, including One Case of Anthrax Meningitis, Occurred in Calabria Region (Italy): A Description of a Successful One Health Approach.

Life (Basel) 2022 Jun 17;12(6). Epub 2022 Jun 17.

Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, 71121 Foggia, Italy.

In this report, three cases of human cutaneous anthrax are described, one complicated by meningitis, and all were linked to a single infected bullock. A 41-year-old male truck driver, along with two male slaughterhouse workers, 45 and 42, were hospitalized for necrotic lesions of the arm associated with edema of the limb and high fever. All three patients were involved in transporting a bullock to the slaughterhouse. Read More

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Some Peculiarities of Anthrax Epidemiology in Herbivorous and Carnivorous Animals.

Life (Basel) 2022 Jun 10;12(6). Epub 2022 Jun 10.

State Research Center for Applied Microbiology and Biotechnology (SRCAMB), 142279 Obolensk, Russia.

Anthrax is an especially dangerous zooanthroponosis caused by the Gram-positive spore-forming bacterium . A notable feature of this disease is the difference in susceptibility to it among different groups of animals. Anthrax primarily affects herbivorous ungulate mammals; they are easily infected, and their disease often leads to rapid, even sudden, death. Read More

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Participatory mapping identifies risk areas and environmental predictors of endemic anthrax in rural Africa.

Sci Rep 2022 Jun 22;12(1):10514. Epub 2022 Jun 22.

Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK.

Disease mapping reveals geographical variability in incidence, which can help to prioritise control efforts. However, in areas where this is most needed, resources to generate the required data are often lacking. Participatory mapping, which makes use of indigenous knowledge, is a potential approach to identify risk areas for endemic diseases in low- and middle-income countries. Read More

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Receptor-enhanced immunogenicity of anthrax protective antigen is primarily mediated by capillary morphogenesis Protein-2.

Vaccine 2022 Jun 13. Epub 2022 Jun 13.

Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Anthrax protective antigen (PA), the receptor-binding component of anthrax toxin, elicits toxin-neutralizing antibodies which provide protection against anthrax disease. PA binds to two mammalian receptors, capillary morphogenesis protein-2 (CMG2) and tumor endothelial marker-8 (TEM8). We previously observed that binding of PA to its receptors plays a role in eliciting a strong toxin-neutralizing antibody response. Read More

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Identification of the molecular characteristics of (1982-2020) isolates in East Indonesia using multilocus variable-number tandem repeat analysis.

Vet World 2022 Apr 16;15(4):953-961. Epub 2022 Apr 16.

Disease Investigation Centre Maros, Directorate General of Livestock Services and Animal Health, Ministry of Agriculture, The Republic of Indonesia, Indonesia.

Background And Aim: Anthrax is one of the endemic strategic diseases in East Indonesia, particularly in the provinces of South Sulawesi, West Sulawesi, Gorontalo, East Nusa Tenggara, and West Nusa Tenggara. Anthrax is an important disease due to its zoonotic and economic impact on the livestock industry. This study aimed to identify the molecular characteristics of in East Indonesia using multilocus variable-number tandem repeat (VNTR) analysis (MLVA). Read More

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Role of site-directed mutagenesis and adjuvants in the stability and potency of anthrax protective antigen.

Saudi Pharm J 2022 May 25;30(5):595-604. Epub 2022 Feb 25.

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Anthrax is a zoonotic infection caused by the gram-positive, aerobic, spore-forming bacterium Depending on the origin of the infection, serious health problems or mortality is possible. The virulence of is reliant on three pathogenic factors, which are secreted upon infection: protective antigen (PA), lethal factor (LF), and edema factor (EF). Systemic illness results from LF and EF entering cells through the formation of a complex with the heptameric form of PA, bound to the membrane of infected cells through its receptor. Read More

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Zoonotic pathogens and diseases detected in Vietnam, 2020-2021.

One Health 2022 Jun 13;14:100398. Epub 2022 May 13.

Food and Agriculture Organization of the United Nations (FAO), Country Office for Vietnam, Hanoi, Vietnam.

Vietnam has been identified as a country at high-risk for emergence and re-emergence of zoonotic diseases. The government of Vietnam recognized five priority zoonoses, including highly pathogenic avian influenza, rabies, leptospirosis, anthrax, and , and established a framework for One Health investigation and response to these diseases. From July 2020 to February 2021, quantitative data of zoonoses were collected from an online survey in 61 of 63 provinces based on either clinical diagnosis or laboratory confirmation. Read More

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AnthraxKP: a knowledge graph-based, Anthrax Knowledge Portal mined from biomedical literature.

Database (Oxford) 2022 Jun;2022

College of Computer and Information Engineering, Inner Mongolia Agricultural University, Erdos East Street No. 29, Hohhot 010011, China.

Anthrax is a zoonotic infectious disease caused by Bacillus anthracis (anthrax bacterium) that affects not only domestic and wild animals worldwide but also human health. As the study develops in-depth, a large quantity of related biomedical publications emerge. Acquiring knowledge from the literature is essential for gaining insight into anthrax etiology, diagnosis, treatment and research. Read More

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Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived sp. CMB-PB041.

J Nat Prod 2022 Jun 31;85(6):1641-1657. Epub 2022 May 31.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Chemical investigation of Australian pasture plant-derived sp. CMB-PB041, supported by miniaturized cultivation profiling and molecular network analysis, led to the isolation and characterization of 13 new macrocyclic spirotetronates, glenthmycins A-M (-), with structures assigned by detailed spectroscopic analysis, chemical degradation and derivatization, and mechanistic and biosynthetic considerations. Hydrolysis of glenthmycin B () yielded the aglycone , whose structure and absolute configuration were secured by X-ray analysis, along with the unexpected amino sugar residues glenthose lactams A () and B (), with Mosher analysis of facilitating assignment of absolute configurations of the amino sugar. Read More

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Conservation and Evolution of the Sporulation Gene Set in Diverse Members of the .

J Bacteriol 2022 Jun 31;204(6):e0007922. Epub 2022 May 31.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Healthgrid.94365.3d, Bethesda, Maryland, USA.

The current classification of the phylum (new name, ) features eight distinct classes, six of which include known spore-forming bacteria. In Bacillus subtilis, sporulation involves up to 500 genes, many of which do not have orthologs in other bacilli and/or clostridia. Previous studies identified about 60 sporulation genes of B. Read More

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Target-enrichment sequencing yields valuable genomic data for challenging-to-culture bacteria of public health importance.

Microb Genom 2022 05;8(5)

Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Genomic data contribute invaluable information to the epidemiological investigation of pathogens of public health importance. However, whole-genome sequencing (WGS) of bacteria typically relies on culture, which represents a major hurdle for generating such data for a wide range of species for which culture is challenging. In this study, we assessed the use of culture-free target-enrichment sequencing as a method for generating genomic data for two bacterial species: (1) which causes anthrax in both people and animals and whose culture requires high-level containment facilities; and (2) , a fastidious emerging human respiratory pathogen. Read More

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Development of Methods for Specific Capture of Biological Targets on Aluminum Substrates: Application to Spore Detection as a Model for Anthrax.

Sensors (Basel) 2022 Apr 30;22(9). Epub 2022 Apr 30.

Department of Dermatology, University of Rochester, Rochester, NY 14642, USA.

Many (if not most) biosensors rely on functional silane coatings as a first step toward covalent immobilization of specific capture molecules. While methods for silanization of silica (SiO) surfaces are very well developed, less has been done to develop and characterize silanization methods for alternative substrates, such as alumina (AlO). In particular, the behavior of AlO coatings grown on aluminum under ambient conditions has not been studied. Read More

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Modelling the ecological niche of naturally occurring anthrax at global and circumpolar extents using an ensemble modelling framework.

Transbound Emerg Dis 2022 May 19. Epub 2022 May 19.

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Bacillus anthracis, the causative agent of anthrax, is a spore-forming bacterium that primarily affects herbivorous livestock, wildlife and humans exposed to direct contact with infected animal carcasses or products. To date, there are a limited number of studies that have delineated the potential global distribution of anthrax, despite the importance of the disease from both an economic and public health standpoint. This study compiled occurrence data (n = 874) of confirmed human and animal cases from 1954 to 2021 in 94 countries. Read More

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Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality, China, August 2021.

China CDC Wkly 2022 Jan;4(1):4-7

Beijing Center for Disease Control and Prevention, Beijing, China.

What Is Already Known About This Topic?: Inhalational anthrax, also known as pulmonary anthrax, is an infectious disease caused by The patients are usually infected by inhaling aerosolized spores from dead animals or animal products. Compared to cutaneous anthrax, inhalational anthrax is rare and deadly and few cases in China were reported.

What Is Added By This Report?: This report covers all information of clinical features, laboratory testing, and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021. Read More

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January 2022

Central serous chorioretinopathy following the BNT162b2 mRNA vaccine.

J Fr Ophtalmol 2022 Jun 13;45(6):597-602. Epub 2022 May 13.

Department of Ophthalmology Shaare-Zedek Medical Center Affiliated with the Hebrew University, Hadassah School of Medicine, Jerusalem, Israel.

Background And Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has accelerated vaccine development. The BNT162b2 messenger RNA (mRNA) vaccine is being administered worldwide. The purpose of this case series is to report a possible association between the BNT162b2 mRNA vaccine and Central serous chorioretinopathy (CSC). Read More

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Rapid Identification of Bacillus anthracis and On-Site Using Novel Single-Nucleotide Polymorphisms.

Microbiol Spectr 2022 May 16:e0228521. Epub 2022 May 16.

State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Biotechnology, Beijing, China.

Bacillus anthracis is a spore-forming bacterium that causes life-threatening infections in animals and humans and has been used as a bioterror agent. Rapid and reliable detection and identification of B. anthracis are of primary interest for both medical and biological threat-surveillance purposes. Read More

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Automatic microscopic diagnosis of diseases using an improved UNet++ architecture.

Tissue Cell 2022 Jun 7;76:101816. Epub 2022 May 7.

Esfarayen Faculty of Medical Sciences, Esfarayen, Iran. Electronic address:

Anthrax is a severe infectious disease caused by the Bacillus anthracis bacterium. This paper aims to design and implement a fast and reliable system based on microscopic image processing of patient tissue samples for the automatic diagnosis of anthrax and other tissues diseases, metastasis detection, patient prognosis, etc. An improved UNet++ architecture is proposed to segment microscopic images of patient tissue samples. Read More

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Seasonality and Ecological Suitability Modelling for Anthrax () in Western Africa.

Animals (Basel) 2022 Apr 29;12(9). Epub 2022 Apr 29.

Food and Agriculture Organization of the United Nations, Sub-Regional Office for Eastern Africa (SFE), CMC Road, Bole Sub City, Kebele 12/13, Addis Ababa P.O. Box 5536, Ethiopia.

Anthrax is hyper-endemic in West Africa affecting wildlife, livestock and humans. Prediction is difficult due to the lack of accurate outbreak data. However, predicting the risk of infection is important for public health, wildlife conservation and livestock economies. Read More

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Rapid Capsular Antigen Immunoassay for Diagnosis of Inhalational Anthrax: Preclinical Studies and Evaluation in a Nonhuman Primate Model.

mBio 2022 May 12:e0093122. Epub 2022 May 12.

Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.

Inhalational anthrax is a fatal infectious disease. Rapid and effective treatment is critically dependent on early and accurate diagnosis. Blood culture followed by identification and confirmation may take days to provide clinically relevant information. Read More

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Highly-fluorescent carbon dots grown onto dendritic silica nanospheres for anthrax protective antigen detection.

Anal Methods 2022 May 19;14(19):1836-1840. Epub 2022 May 19.

Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.

Direct synthesis of carbon dots on uniform mesoporous nanospheres is an ideal way to impart fluorescence properties to the nanomaterials and retain its original uniformity. Carbon dot-based nanospheres with high quantum yield (aqueous solution, 89.3%) were synthesized by the one-step hydrothermal treatment of sodium citrate and dendritic silica spheres grafted with -β-(aminoethyl)-γ-aminopropyltrimethoxysilane. Read More

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[Characterization and temporal evolution of mortality due to zoonoses under mandatory declaration, between the years 1997 and 2018].

Rev Chilena Infectol 2021 10;38(5):667-677

Instituto de Salud Poblacional, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Background: Zoonoses are diseases transmitted from an animal host to humans or vice versa. In Chile, the zoonoses of mandatory notification are brucellosis, anthrax, trichinosis, hydatidosis, leptospirosis, dengue, Chagas disease, hantavirosis and rabies.

Aim: To assess the trend and characterize the mortality from zoonoses of mandatory notification in Chile between 1997-2018. Read More

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October 2021

Aerosol Test Chambers: Current State and Practice During the COVID-19 Pandemic.

Front Bioeng Biotechnol 2022 12;10:863954. Epub 2022 Apr 12.

JRAD, Stafford, VA, United States.

Respiratory infectious disease outbreaks such as those caused by coronaviruses and influenza, necessitate the use of specialized aerosol test chambers to study aspects of these causative agents including detection, efficacy of countermeasures, and aerosol survivability. The anthrax attacks from 2001 and earlier biowarfare and biodefense also influenced the study of biological aerosols to learn about how certain pathogens transmit either naturally or through artificial means. Some high containment biological laboratories, which work with Risk Group 3 and 4 agents in biosafety level -3, biosafety level-4 containment, are equipped with aerosol test chambers to enable the study of high-risk organisms in aerosolized form. Read More

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[Analysis of epidemic characteristics of anthrax in China from 2017 to 2019 and molecular typing of ].

Zhonghua Yu Fang Yi Xue Za Zhi 2022 Apr;56(4):422-426

National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory of Infectious Disease Prevention and Control, Beijing 102206, China.

To analyze the epidemiological characteristics of anthrax in China from 2017 to 2019 and molecular typing of isolated from some provinces (autonomous regions). Surveillance data of anthrax cases reported from 2017 to 2019 in the Infectious Disease Surveillance information System of China Disease Prevention and Control and the Public Health Emergency Reporting and Management Information System were collected, and descriptive epidemiological methods were used to analyze the epidemic characteristics, including the temporal, geographic and demographic distribution of this disease. A total of 47 strains of isolated from 2017 to 2019 were analyzed by canSNP and MLVA15. Read More

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Designing Stable Antigens with a View to Recombinant Anthrax Vaccine Development.

Pharmaceutics 2022 Apr 6;14(4). Epub 2022 Apr 6.

Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.

Anthrax is a disease caused by that affects mammals, including humans. Recombinant protective antigen (rPA) is the most common basis for modern anthrax vaccine candidates. However, this protein is characterised by low stability due to proteolysis and deamidation. Read More

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Ecological Niche Model of Group Isolates Containing a Homologue of the pXO1 Anthrax Toxin Genes Infecting Metalworkers in the United States.

Pathogens 2022 Apr 14;11(4). Epub 2022 Apr 14.

Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

While typically causes opportunistic infections in humans, within the last three decades, severe and fatal infections caused by isolates of the group harboring anthrax toxin genes have been reported in the United States. From 1994 to 2020, seven cases of anthrax-like illness resulting from these isolates have been identified. With one exception, the cases have occurred in the Gulf States region of the United States among metalworkers. Read More

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Welder's Anthrax: A Review of an Occupational Disease.

Pathogens 2022 Mar 26;11(4). Epub 2022 Mar 26.

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA.

Since 1997, nine cases of severe pneumonia, caused by species within the group and with a presentation similar to that of inhalation anthrax, were reported in seemingly immunocompetent metalworkers, with most being welders. In seven of the cases, isolates were found to harbor a plasmid similar to the pXO1 that encodes anthrax toxins. In this paper, we review the literature on the group spp. Read More

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Louis Pasteur: Between Myth and Reality.

Biomolecules 2022 04 18;12(4). Epub 2022 Apr 18.

Centre de Ressources en Information Scientifique, Institut Pasteur, 75015 Paris, France.

Louis Pasteur is the most internationally known French scientist. He discovered molecular chirality, and he contributed to the understanding of the process of fermentation, helping brewers and winemakers to improve their beverages. He proposed a process, known as pasteurization, for the sterilization of wines. Read More

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