7,304 results match your criteria Anthrax


Detection of Bacillus anthracis in Animal Tissues using InBios Active Anthrax Detect Rapid Test Lateral Flow Immunoassay.

Lett Appl Microbiol 2019 Feb 18. Epub 2019 Feb 18.

Centers for Disease Control and Prevention, Atlanta, Georgia, 30333.

The Active Anthrax Detect (AAD) Rapid Test lateral flow immunoassay is a point-of-care assay that was under investigational use for detecting Bacillus anthracis capsular polypeptide (polyglutamic acid) in human blood, serum, and plasma. Small sample volumes, rapid results, and no refrigeration required allow for easy use in either the field or laboratory. Although the test was developed for use in suspect cases of human inhalation anthrax, its features also make it a potentially powerful tool for testing suspect animal cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/lam.13134DOI Listing
February 2019

Single dose of DPX-rPA, an enhanced-delivery anthrax vaccine formulation, protects against a lethal spore inhalation challenge.

NPJ Vaccines 2019 8;4. Epub 2019 Feb 8.

IMV Inc., 130 Eileen Stubbs Avenue, Suite 19, Dartmouth, NS B3B 2C4 Canada.

Anthrax is a serious biological threat caused by pulmonary exposure to aerosolized spores of . Biothrax (anthrax vaccine adsorbed (AVA)) is the only Food and Drug Administration-licensed vaccine and requires five administrations over 12 months with annual boosting to maintain pre-exposure prophylaxis. Here we report the evaluation of a single intramuscular injection of recombinant -protective antigen (rPA) formulated in the DPX delivery platform. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41541-019-0102-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368554PMC
February 2019

B. anthracis Lethal Toxin but not Edema Toxin, Increases Pulmonary Artery Pressure and Permeability in Isolated Perfused Rat Lungs.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

Critical Care Medicine Department, National Institutes of Health, United States.

Introduction: Although lethal (LT) and edema toxin (ET) contribute to lethality during Bacillus anthracis infection, whether they increase vascular permeability and the extravascular fluid accumulation characterizing this infection is unclear. We employed an isolated perfused Sprague-Dawley rat lung model to investigate LT and ETs effects on pulmonary vascular permeability.

Methods And Results: Lungs (n≥6 per experimental group) were isolated, ventilated, suspended from a force transducer and perfused. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00685.2018DOI Listing
February 2019

[Update of knowledge on Neglected Diseases in Haiti: Mansonelliasis, Tungiasis, Leprosy, and Anthrax].

Bull Soc Pathol Exot 2018 ;111(1):17-23

Direction d'épidémiologie, de laboratoire et de recherches, 52 angle Delmas 33 et rue Charbonnières, Port-au-Prince, Haïti.

Haiti, like most limited-resources countries in the world, faces numerous neglected infectious diseases. They represent a real public health issue with lethal consequences especially in children. We are reviewing here the available literature on four neglected infectious diseases, mansonelliasis, tungiasis, leprosy and anthrax. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3166/bspe-2018-0005DOI Listing
January 2018

Cutaneous Anthrax Outbreak in the Trakya Region of Turkey

Balkan Med J 2019 01 31. Epub 2019 Jan 31.

Department of Infectious Diseases, Trakya University School of Medicine, Edirne, Turkey

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/balkanmedj.galenos.2019.2018.12.19DOI Listing
January 2019

Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication.

FASEB J 2019 Jan 30:fj201802453R. Epub 2019 Jan 30.

Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.

The antibiotic bacitracin (Bac) inhibits cell wall synthesis of gram-positive bacteria. Here, we discovered a totally different activity of Bac: the neutralization of bacterial exotoxins. Bac prevented intoxication of mammalian cells with the binary enterotoxins Clostridium botulinum C2, C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201802453RDOI Listing
January 2019
1 Read

Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives.

Mol Divers 2019 Jan 29. Epub 2019 Jan 29.

Jiangsu Key Laboratory of Pesticide, College of Sciences, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.

We synthesized a series of novel pyrrole- and pyrazole-substituted coumarin derivatives and evaluated their antifungal activity against six phytopathogenic fungi in vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds 5g, 6a, 6b, 6c, 6d and 6h exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11030-019-09920-zDOI Listing
January 2019
1 Read
1.896 Impact Factor

Role of ANTXR1 in the regulation of RANKL-induced osteoclast differentiation and function.

Biochem Biophys Res Commun 2019 Mar 25;510(2):296-302. Epub 2019 Jan 25.

Division of Rheumatology, Department of Internal Medicine, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk, 570-749, Republic of Korea. Electronic address:

Anthrax toxin receptor 1 (ANTXR1) is a transmembrane protein with an extracellular domain which is deeply associated with the process of bone formation and plays an important role in angiogenesis. However, there have been no reports investigating the effects of ANTXR1 on bone metabolism mediated by the two types of bone cells, osteoclasts, and osteoblasts. The aim of this study is to reveal the role of ANTXR1 in the differentiation and function of osteoclasts and osteoblasts. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X193011
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2019.01.094DOI Listing
March 2019
4 Reads

A participatory epidemiological study of major cattle diseases amongst Maasai pastoralists living in wildlife-livestock interfaces in Maasai Mara, Kenya.

Trop Anim Health Prod 2019 Jan 25. Epub 2019 Jan 25.

International Livestock Research Institute, (ILRI), P. O BOX 30709, Nairobi, 00100, Kenya.

Livestock-wildlife interactions promote the transmission of a wide range of infectious diseases that constraint livestock production. We used a participatory appraisal approach to find out and rank infectious diseases of concern to pastoralists in a zone of intense wildlife-livestock interaction and another zone with limited interactions. Four villages were selected purposively in areas with intensive cattle-wildlife interactions (zone 1), and another two in areas with low to moderate cattle-wildlife interactions (zone 2). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11250-018-01790-1DOI Listing
January 2019
1 Read

Development of a novel multiepitope chimeric vaccine against anthrax.

Med Microbiol Immunol 2019 Jan 22. Epub 2019 Jan 22.

Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.

Bacillus anthracis (BA), the etiological agent of anthrax, secretes protective antigen (PA), lethal factor (LF), and edema factor (EF) as major virulence mediators. Amongst these, PA-based vaccines are most effective for providing immunity against BA, but their low shelf life limits their usage. Previous studies showed that B-cell epitopes, ID II and ID III present in PA domain IV possess higher toxin neutralization activity and elicit higher antibody titer than ID I. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00430-019-00577-xDOI Listing
January 2019

Genome sequence of Bacillus anthracis typing phage AP631.

Arch Virol 2019 Jan 21. Epub 2019 Jan 21.

State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing, 100071, China.

AP631, a virulent bacteriophage of Bacillus anthracis, is widely used in China to identify anthrax bacteria. In this study, we report the complete AP631 phage genome sequence as well as comparative genomic analysis with other bacteriophages of B. cereus and related species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00705-018-04135-3DOI Listing
January 2019

Systematic mutational analysis of human neutrophil α-defensin HNP4.

Biochim Biophys Acta Biomembr 2019 Jan 15;1861(4):835-844. Epub 2019 Jan 15.

Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, USA.

Defensins are a family of cationic antimicrobial peptides of innate immunity with immunomodulatory properties. The prototypic human α-defensins, also known as human neutrophil peptides 1-3 or HNP1-3, are extensively studied for their structure, function and mechanisms of action, yet little is known about HNP4 - the much less abundant "distant cousin" of HNP1-3. Here we report a systematic mutational analysis of HNP4 with respect to its antibacterial activity against E. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamem.2019.01.007DOI Listing
January 2019
7 Reads
3.836 Impact Factor

Genome Sequences of Penicillin-Resistant Bacillus anthracis Strains.

Microbiol Resour Announc 2019 Jan 10;8(2). Epub 2019 Jan 10.

Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Bacillus anthracis, the etiologic agent of anthrax, is characteristically susceptible to penicillin despite containing two chromosomal β-lactamase genes. Few naturally occurring penicillin-resistant B. anthracis isolates have been reported. Read More

View Article

Download full-text PDF

Source
http://genomea.asm.org/lookup/doi/10.1128/MRA.01122-18
Publisher Site
http://dx.doi.org/10.1128/MRA.01122-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328647PMC
January 2019
6 Reads

Tale of 2 Orifices.

Circ Cardiovasc Imaging 2019 Dec;12(1):e008372

Leon H Charney Division of Cardiology (A.F.V., M.S.), New York University Langone Medical Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCIMAGING.118.008372DOI Listing
December 2019
7 Reads

An ELISA using a recombinant chimera of protective antigen and lethal factor for serodiagnosis of cutaneous anthrax in India.

Biologicals 2019 Jan 8;57:55-60. Epub 2019 Jan 8.

Defence Research & Development Establishment, Jhansi Road, Gwalior, 474 002, India. Electronic address:

In this study, an ELISA was developed for simultaneous detection of antibodies against both the important toxins of B. anthracis i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biologicals.2019.01.001DOI Listing
January 2019
2 Reads
1.209 Impact Factor

A new triple chimeric protein as a high immunogenic antigen against anthrax toxins: theoretical and experimental analyses.

Immunopharmacol Immunotoxicol 2019 Jan 9:1-7. Epub 2019 Jan 9.

b Faculty of Biological Sciences , Tarbiat Modares University , Tehran , Iran.

Background: Anthrax is a zoonotic disease caused by Bacillus anthracis and it can be deadly in 6 days. Considerable efforts have been conducted toward developing more effective veterinary and human anthrax vaccines because these common vaccines have several limitations. B. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
Publisher Site
http://dx.doi.org/10.1080/08923973.2018.1510419DOI Listing
January 2019
5 Reads
1.109 Impact Factor

Europium functionalized silicon quantum dots nanomaterials for ratiometric fluorescence detection of Bacillus anthrax biomarker.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 21;212:88-93. Epub 2018 Dec 21.

College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, PR China. Electronic address:

Bacillus anthracis spore causes anthrax to seriously threaten human health and even cause death. 2,6-Pyridinedicarboxylic acid (DPA) is a unique biomarker because it is a major component of Bacillus anthracis spore. Herein, we design europium functionalized silicon quantum dots as a ratiometric fluorescent nanoprobe to detect DPA with high sensitivity and selectivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2018.12.036DOI Listing
April 2019
1 Read

Bacillus species at the Canberra Airport: A comparison of real-time polymerase chain reaction and massively parallel sequencing for identification.

Forensic Sci Int 2019 Feb 21;295:169-178. Epub 2018 Dec 21.

National Centre for Forensic Studies, University of Canberra, Bruce, ACT, 2617, Australia; Centre for Forensic Science, School of Mathematical & Physical Sciences (MaPS), Faculty of Science, University of Technology Sydney, Broadway, NSW, 2007, Australia. Electronic address:

Anthrax, caused by the Gram-positive, spore forming bacterium Bacillus anthracis, is a disease with naturally occurring outbreaks in many parts of the world, primarily in domestic and wild herbivores. Due to the movement of people and stock, B. anthracis could, however, be at transportation hubs including airports. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.forsciint.2018.12.011DOI Listing
February 2019
1 Read

Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes.

Proc Natl Acad Sci U S A 2019 Jan 4;116(4):1279-1288. Epub 2019 Jan 4.

Global Health Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

The protein acyl transferase ZDHHC5 was recently proposed to regulate trafficking in the endocytic pathway. Therefore, we explored the function of this enzyme in controlling the action of bacterial toxins. We found that ZDHHC5 activity is required for two very different toxins: the anthrax lethal toxin and the pore-forming toxin aerolysin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1812588116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347675PMC
January 2019
4 Reads

Evolutionary Features in the Structure and Function of Bacterial Toxins.

Toxins (Basel) 2019 Jan 3;11(1). Epub 2019 Jan 3.

Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA 02747, USA.

Toxins can function both as a harmful and therapeutic molecule, depending on their concentrations. The diversity in their function allows us to ask some very pertinent questions related to their origin and roles: (a) What makes them such effective molecules? (b) Are there evolutionary features encoded within the structures of the toxins for their function? (c) Is structural hierarchy in the toxins important for maintaining their structure and function? (d) Do protein dynamics play a role in the function of toxins? and (e) Do the evolutionary connections to these unique features and functions provide the fundamental points in driving evolution? In light of the growing evidence in structural biology, it would be appropriate to suggest that protein dynamics and flexibility play a much bigger role in the function of the toxin than the structure itself. Discovery of IDPs (intrinsically disorder proteins), multifunctionality, and the concept of native aggregation are shaking the paradigm of the requirement of a fixed three-dimensional structure for the protein's function. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2072-6651/11/1/15
Publisher Site
http://dx.doi.org/10.3390/toxins11010015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356308PMC
January 2019
13 Reads
2.480 Impact Factor

A therapeutic human antibody against the domain 4 of the Bacillus anthracis protective antigen shows protective efficacy in a mouse model.

Biochem Biophys Res Commun 2019 Feb 31;509(2):611-616. Epub 2018 Dec 31.

Division of High-risk Pathogens, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, 28159, South Korea. Electronic address:

Since Bacillus anthracis is a high-risk pathogen and a potential tool for bioterrorism, numerous therapeutic methods including passive immunization have been actively developed. Using a human monoclonal antibody phage display library, we screened new therapeutic antibodies for anthrax infection against protective antigen (PA) of B. anthracis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0006291X183281
Publisher Site
http://dx.doi.org/10.1016/j.bbrc.2018.12.146DOI Listing
February 2019
7 Reads

Mapping the epidemiological distribution and incidence of major zoonotic diseases in South Tigray, North Wollo and Ab'ala (Afar), Ethiopia.

PLoS One 2018 31;13(12):e0209974. Epub 2018 Dec 31.

College of Veterinary Medicine, Mekelle University, Mekelle, Ethiopia.

Zoonotic diseases continue to affect the health and livelihood of resource limited communities. In Ethiopia, despite the presence of a national master plan for prevention, control and elimination of some common zoonotic diseases, well-organized epidemiological data regarding incidence and distribution are lacking. A retrospective cross-sectional study based on a patient medical data recorded from 2012-2016 in selected districts of Southern Tigray, North Wollo zone of Amhara region and Ab'Ala district of Afar region was conducted to map the distribution and Incidence proportion of major zoonotic diseases. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209974PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312287PMC
December 2018
2 Reads

Adult Immunization - Need of the Hour.

J Int Soc Prev Community Dent 2018 Nov-Dec;8(6):475-481. Epub 2018 Nov 29.

Department of Public Health Dentistry, College of Applied Health Sciences in Ar Rass, Qassim University, Buraydah, Saudi Arabia.

Immunization is the process of making individuals immune. Childhood immunization is a common process for various aliments, but adult immunization in the Indian scenario is obscure. Officially, India has been declared polio-free, which is an achievement despite cultural, political, economic, geographic, and so many other factors. Read More

View Article

Download full-text PDF

Source
http://www.jispcd.org/text.asp?2018/8/6/475/246408
Publisher Site
http://dx.doi.org/10.4103/jispcd.JISPCD_347_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280562PMC
November 2018
5 Reads

Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.

FASEB J 2018 Dec 28:fj201801440R. Epub 2018 Dec 28.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany; and.

Clostridium difficile is associated with antibiotic-associated diarrhea and pseudomembranous colitis in humans. Its 2 major toxins, toxins A and B, enter host cells and inactivate GTPases of the Ras homologue/rat sarcoma family by glucosylation. Pore formation of the toxins in the endosomal membrane enables the translocation of their glucosyltransferase domain into the cytosol, and membrane cholesterol is crucial for this process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201801440RDOI Listing
December 2018
1 Read

The threat of bioterrorism.

Lancet Infect Dis 2019 Jan;19(1):18-19

Infectious Diseases Department, Hôpital d'Instruction des Armées Laveran, Marseille, France.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14733099183070
Publisher Site
http://dx.doi.org/10.1016/S1473-3099(18)30709-6DOI Listing
January 2019
2 Reads

Identification of Therapeutically Active Molecules against Anthrax through Structure and Ligand based Drug Design.

Curr Top Med Chem 2018 ;18(27):2294-2312

Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow-226031, India.

Background: People suffer from fatal diseases which are responsible for mortality. Potent devices and medicines are being developed to fight diseases caused by the microorganism for saving the lives of individuals. Highly pathogenic viruses and bacteria are being incorporated into biological warfare, which has become a major threat to mankind and causes the destruction of lives in a short span of time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1568026619666181221162051DOI Listing
January 2018
2 Reads

Hydrogen peroxide-assisted ultrasonic synthesis of BCNO QDs for the anthrax biomarker detection.

ACS Appl Mater Interfaces 2018 Dec 21. Epub 2018 Dec 21.

A facile 3% hydrogen peroxide-assisted ultrasonic synthetic strategy is demonstrated to successfully synthesize fluorescent boron carbon oxynitride quantum dots (BCNO QDs). The obtained BCNO QDs exhibit intense blue fluorescence, favorable biocompatibility and water-solubility. The quantum yield of the BCNO QDs is 19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.8b21786DOI Listing
December 2018

Analysis of Whole-Genome Sequences for the Prediction of Penicillin Resistance and β-Lactamase Activity in .

mSystems 2018 Nov-Dec;3(6). Epub 2018 Dec 11.

Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Penicillin (PEN) is a low-cost option for anthrax treatment, but naturally occurring resistance has been reported. β-Lactamase expression (, ) in Bacillus anthracis is regulated by a sigma factor (SigP) and its cognate anti-sigma factor (RsiP). Mutations leading to truncation of RsiP were previously described as a basis for PEN resistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mSystems.00154-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290263PMC
December 2018

Laboratory strains of Bacillus anthracis exhibit pervasive alteration in expression of proteins related to sporulation under laboratory conditions relative to genetically related wild strains.

PLoS One 2018 17;13(12):e0209120. Epub 2018 Dec 17.

Chemical and Biological Signature Science, Pacific Northwest National Laboratory, Richland, Washington, United States of America.

The spore forming pathogen Bacillus anthracis is the etiologic agent of anthrax in humans and animals. It cycles through infected hosts as vegetative cells and is eventually introduced into the environment where it generates an endospore resistant to many harsh conditions. The endospores are subsequently taken up by another host to begin the next cycle. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209120PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296524PMC
December 2018

Evaluation of antimicrobial susceptibility of strains isolated during anthrax outbreaks in Italy from 1984 to 2017.

J Vet Sci 2019 Jan;20(1):58-62

Anthrax Reference Institute of Italy, Experimental Zooprophylactic Institute of Puglia and Basilicata Regions, Foggia 71121, Italy.

Anthrax, caused by , is a non-contagious infectious disease that affects a wide range of animal species (primarily ruminants) including humans. Due to the often-fatal outcome in humans, quick administration of definitely effective antimicrobials is crucial either as prophylaxis or as a clinical case therapy. In this study, 110 strains, temporally, geographically, and genetically different, isolated during anthrax outbreaks in Italy from 1984 to 2017, were screened using a broth microdilution method to determine their susceptibility to 16 clinically relevant antimicrobial agents. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4142/jvs.2019.20.1.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351761PMC
January 2019
5 Reads

Decoupling environmental effects and host population dynamics for anthrax, a classic reservoir-driven disease.

PLoS One 2018 12;13(12):e0208621. Epub 2018 Dec 12.

Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.

Quantitative models describing environmentally-mediated disease transmission rarely focus on the independent contribution of recruitment and the environment on the force of infection driving outbreaks. In this study we attempt to investigate the interaction between external factors and host's population dynamics in determining the outbreaks of some indirectly transmitted diseases. We first built deterministic and stochastic compartmental models based on anthrax which were parameterized using information from literature and complemented with field observations. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208621PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291251PMC
December 2018
9 Reads

Closed Genome Sequence Obtained Using Hybrid Nanopore/Illumina Assembly of a Bacillus anthracis Isolate from an Animal-Skin-Drum-Associated Anthrax Case in the United Kingdom.

Microbiol Resour Announc 2018 Oct 4;7(13). Epub 2018 Oct 4.

Public Health England, National Infection Service, Salisbury, Wiltshire, United Kingdom.

Hybrid assembly of Illumina/Nanopore reads produced a complete closed genome sequence of the chromosome and two virulence plasmids of a Bacillus anthracis isolate from a fatal anthrax case in the United Kingdom linked to imported animal skins/drums; this provides a high-quality representative sequence for this lineage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MRA.00802-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256555PMC
October 2018
1 Read

A niosome formulation modulates the Th1/Th2 bias immune response in mice and also provides protection against anthrax spore challenge.

Int J Nanomedicine 2018 14;13:7427-7440. Epub 2018 Nov 14.

Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India,

Introduction: In this study, we have investigated the immunogenicity and protective efficacy of a niosomal formulation encapsulating protective antigen (PA) and PA domain 4 (D4) of .

Methods: Nonionic surfactant-based vesicles (NISV) + PA and NISV + D4 were prepared from span-60 and cholesterol by reverse-phase evaporation method and were evaluated for in vitro characteristics and immunological studies.

Results: Particle characterization using transmission electron microscopy and atomic force microscopy analysis showed that the niosomal formulation was spherical in shape. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S153150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241689PMC
January 2019
1 Read

Human monoclonal anti-protective antigen antibody for the low-dose post-exposure prophylaxis and treatment of Anthrax.

BMC Infect Dis 2018 Dec 10;18(1):640. Epub 2018 Dec 10.

Key Laboratory of Antibody Technique of National Health and Family Planning Commission, Nanjing Medical University, Nanjing, 210029, China.

Background: Disease caused by Bacillus anthracis is often accompanied by high mortality primarily due to toxin-mediated injury. In the early disease course, anthrax toxins are secreted; thus, antibiotic use is limited to the early stage. In this regard, antibodies against the toxin component, protective antigen (PA), play an important role in protecting against anthrax. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-018-3542-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288905PMC
December 2018
1 Read

Ecological niche modeling as a tool for prediction of the potential geographic distribution of Bacillus anthracis spores in Tanzania.

Int J Infect Dis 2019 Feb 3;79:142-151. Epub 2018 Dec 3.

Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway. Electronic address:

Introduction: Anthrax is caused by the spore-forming, Gram-positive bacterium Bacillus anthracis. The aim of this study was to predict the potential distribution of B. anthracis in Tanzania and produce epidemiological evidence for the management of anthrax outbreaks in the country. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2018.11.367DOI Listing
February 2019
3 Reads
2.330 Impact Factor

Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1.

Proc Natl Acad Sci U S A 2018 12 4;115(51):13087-13092. Epub 2018 Dec 4.

Drug Discovery Center for Infectious Disease, College of Pharmacy, Nankai University, 300071 Tianjin, China.

Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. SVV mediates cell entry by attachment to the receptor anthrax toxin receptor 1 (ANTXR1). Here we determine atomic structures of mature SVV particles alone and in complex with ANTXR1 in both neutral and acidic conditions, as well as empty "spent" particles in complex with ANTXR1 in acidic conditions by cryoelectron microscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1814309115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304951PMC
December 2018
13 Reads
9.809 Impact Factor

Infection with a Nonencapsulated Strain in Rabbits-The Role of Bacterial Adhesion and the Potential for a Safe Live Attenuated Vaccine.

Toxins (Basel) 2018 Dec 1;10(12). Epub 2018 Dec 1.

Department of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 74100, Israel.

Nonencapsulated (∆pXO2) strains are commonly used as vaccines and for anthrax research, mainly in the mouse model. Previously, we demonstrated that the infection of rabbits, intranasally or subcutaneously, with the spores of a fully virulent strain results in the systemic dissemination of the bacteria, meningitis, and death, whereas ∆pXO2 strains are fully attenuated in this animal model. We used the intravenous inoculation of rabbits to study the pathogenicity of the ∆pXO2 strain infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/toxins10120506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316610PMC
December 2018
2 Reads

Spatio-temporal epidemiology of anthrax in Hippopotamus amphibious in Queen Elizabeth Protected Area, Uganda.

PLoS One 2018 28;13(11):e0206922. Epub 2018 Nov 28.

Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minneapolis, United States of America.

Background: Anthrax is a zoonotic disease primarily of herbivores, caused by Bacillus anthracis, a bacterium with diverse geographical and global distribution. Globally, livestock outbreaks have declined but in Africa significant outbreaks continue to occur with most countries still categorized as enzootic, hyper endemic or sporadic. Uganda experiences sporadic human and livestock cases. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206922PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261556PMC
November 2018

Seneca Valley Virus Exploits TEM8, a Collagen Receptor Implicated in Tumor Growth.

Front Oncol 2018 6;8:506. Epub 2018 Nov 6.

Department of Chemistry, Wichita State University, Wichita, KS, United States.

Recent studies reveal that Seneca Valley Virus (SVV) exploits tumor endothelial marker 8 (TEM8) for cellular entry, the same surface receptor pirated by bacterial-derived anthrax toxin. This observation is particularly significant as SVV is a known oncolytic virus which selectively infects and kills tumor cells, particularly those of neuroendocrine origin. TEM8 is a transmembrane glycoprotein that is preferentially upregulated in some tumor cell and tumor-associated stromal cell populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2018.00506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232524PMC
November 2018
8 Reads

Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes.

Nat Commun 2018 11 19;9(1):4857. Epub 2018 Nov 19.

Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Ed. C8, Campo Grande, 1749-016, Lisboa, Portugal.

Anthrax is an infectious disease caused by Bacillus anthracis, a bioterrorism agent that develops resistance to clinically used antibiotics. Therefore, alternative mechanisms of action remain a challenge. Herein, we disclose deoxy glycosides responsible for specific carbohydrate-phospholipid interactions, causing phosphatidylethanolamine lamellar-to-inverted hexagonal phase transition and acting over B. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-018-06488-4
Publisher Site
http://dx.doi.org/10.1038/s41467-018-06488-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242839PMC
November 2018
26 Reads

Immunogenicity of anthrax recombinant peptides and killed spores in goats and protective efficacy of immune sera in A/J mouse model.

Sci Rep 2018 Nov 16;8(1):16937. Epub 2018 Nov 16.

Department of Veterinary Tropical Diseases, University of Pretoria, Onderstepoort, South Africa.

Anthrax is primarily recognized as an affliction of herbivores with incubation period ranging from three to five days post-infection. Currently, the Sterne live-spore vaccine is the only vaccine approved for control of the disease in susceptible animals. While largely effective, the Sterne vaccine has several problems including adverse reactions in sensitive species, ineffectiveness in active outbreaks and incompatibility with antibiotics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-35382-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240085PMC
November 2018
2 Reads

Phenotypic variations in transferred progeny due to genotype of surrogate mother.

Mol Hum Reprod 2019 Feb;25(2):88-99

Department of Experimental Animal Genetic Resources, Laboratory of the Genetics of Experimental Animals, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia.

Study Question: Does the genotype of the surrogate mother modulate the body composition and immunity of her offspring?

Summary Answer: C57BL/6J (B6) progenies carried by immunodeficient NOD SCID (NS) mothers had increased adaptive but decreased innate, immune responsiveness in comparison with the same genotype offspring carried by immunocompetent mothers, B6 and BALB/c (C); the B6 progenies carried by the same genotype mothers also showed higher body fat than the others.

What Is Known Already: Differences in the major histocompatibility complex (MHC) genes between mother and foetus is considered as an important factor in prenatal embryo development, whereas the impact of such dissimilarity on the phenotype of the mature progeny is unclear.

Study Design, Size, Duration: Transplantation of two-cell mouse embryos into recipient females of the different MHC (H2) genotypes was used as an approach to simulate three variants of the immunogenic mother-foetus interaction: (i) bidirectional immunogenic dialogue between B6 (H2b haplotype) embryos and C (H2d haplotype) surrogate mother; (ii) one-way immunogenic interaction between B6 embryos and immunodeficient NS (H2g7 haplotype) surrogate mother and (iii) reduced immunogenetic dialogue between embryos and surrogate mother of the same H2b haplotype resulting in only a maternal response to HY antigens of male foetuses. Read More

View Article

Download full-text PDF

Source
http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
Publisher Site
http://dx.doi.org/10.1093/molehr/gay052DOI Listing
February 2019
13 Reads

Vaccination and risk of lone atrial fibrillation in the active component United States military.

Hum Vaccin Immunother 2018 Nov 16. Epub 2018 Nov 16.

a Immunization Safety Office, Division of Healthcare Quality Promotion , National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention.

Purpose: To evaluate the hypothesis that receipt of anthrax vaccine adsorbed (AVA) increases the risk of atrial fibrillation in the absence of identifiable underlying risk factors or structural heart disease (lone atrial fibrillation).

Methods: We conducted a retrospective population-based cohort study among U.S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21645515.2018.1549453DOI Listing
November 2018
13 Reads

Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells.

Cell Microbiol 2019 Mar 2;21(3):e12978. Epub 2018 Dec 2.

Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Photorhabdus luminescens Tc toxins consist of the cell-binding component TcA, the linker component TcB, and the enzyme component TcC. TccC3, a specific isoform of TcC, ADP-ribosylates actin and causes redistribution of the actin cytoskeleton. TccC5, another isoform of TcC, ADP-ribosylates and activates Rho proteins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cmi.12978DOI Listing
March 2019
1 Read

Genetic characteristics of Bacillus anthracis isolated from northwestern China from 1990 to 2016.

PLoS Negl Trop Dis 2018 11 12;12(11):e0006908. Epub 2018 Nov 12.

National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Anthrax is a global re-emerging zoonotic disease and is an endemic disease in China, especially in rural regions. In this study, the general characteristics of human anthrax outbreaks that occurred in areas of northwestern China over the past decade have been described. Meanwhile, the genetic characteristics of Bacillus anthracis isolated from these areas from 1990 to 2016 were analyzed by means of canonical single-nucleotide polymorphism (canSNP) analysis and multilocus variable-number tandem repeat analysis (MLVA) with 15 markers. Read More

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pntd.0006908
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0006908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258423PMC
November 2018
11 Reads

Anthrax Exposure, Belief in Exposure, and Postanthrax Symptoms Among Survivors of a Bioterrorist Attack on Capitol Hill.

Disaster Med Public Health Prep 2018 Nov 12:1-6. Epub 2018 Nov 12.

5The Altshuler Center for Education & Research at Metrocare Services and the Department of Psychiatry,The University of Texas Southwestern Medical Center,Dallas,Texas.

Background: Following chemical, biological, radiological, and nuclear disasters, medically unexplained symptoms have been observed among unexposed persons.

Objectives: This study examined belief in exposure in relation to postdisaster symptoms in a volunteer sample of 137 congressional workers after the 2001 anthrax attacks on Capitol Hill.

Methods: Postdisaster symptoms, belief in exposure, and actual exposure status were obtained through structured diagnostic interviews and self-reported presence in offices officially designated as exposed through environmental sampling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/dmp.2018.115DOI Listing
November 2018
4 Reads

Medical Spending for the 2001 Anthrax Letter Attacks.

Disaster Med Public Health Prep 2018 Nov 12:1-8. Epub 2018 Nov 12.

2Concordia University, Montreal,Quebec.

ABSTRACTIntroductionThis paper assesses the total medical costs associated with the US anthrax letter attacks of 2001. This information can be used to inform policies, which may help mitigate the potential economic impacts of similar bioterrorist attacks.

Methods: Journal publications and news reports were reviewed to establish the number of people who were exposed, were potentially exposed, received prophylactics, and became ill. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/dmp.2018.113DOI Listing
November 2018
1 Read