7,333 results match your criteria Anthrax


Anthrax Epizootic in Wildlife, Bwabwata National Park, Namibia, 2017.

Emerg Infect Dis 2019 May;25(5):947-950

In late September 2017, Bwabwata National Park in Namibia experienced a sudden die-off of hippopotamuses and Cape buffalo. A multiorganizational response was initiated, involving several ministries within Namibia and the US Centers for Disease Control and Prevention. Rapid interventions resulted in zero human or livestock cases associated with this epizootic. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-0867_article.htm
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http://dx.doi.org/10.3201/eid2505.180867DOI Listing
May 2019
4 Reads

Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in .

PeerJ 2019 12;7:e6718. Epub 2019 Apr 12.

Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.

The anthrax toxin is a virulence factor produced by the bacterium . Transcription of anthrax toxin genes is controlled by the transcription factor AtxA. Thus, AtxA is thought to be a key factor for the pathogenicity of . Read More

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https://peerj.com/articles/6718
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http://dx.doi.org/10.7717/peerj.6718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463858PMC
April 2019
2 Reads

Emergency Response for a Laboratory Biosafety Incident.

Biomed Environ Sci 2019 Mar;32(3):231-233

Chinese Center for Disease Control and Prevention, Beijing 102206, China.

On December 14, 2017, a faculty member of a university in Hunan Province reported that an anthrax vaccine strain might have recovered virulence during an undergraduate experiment and potential exposure could not be ruled out for the students involved. Upon receiving the case report, the CDC, health bureaus, and local governments at the county, prefectural, and provincial levels promptly organized experts in different fields (including epidemiologists, biosafety experts, and laboratory testing experts) for case investigation, evaluation, and response. As the investigation results showed, no virulence recovery was identified in the involved anthrax vaccine strain; and no contamination of Bacillus anthracis was detected at the involved areas. Read More

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http://dx.doi.org/10.3967/bes2019.032DOI Listing

Tumor imaging using radiolabelled matrix metalloproteinase-activated anthrax proteins.

J Nucl Med 2019 Apr 6. Epub 2019 Apr 6.

Department of Oncology, University of Oxford, United Kingdom.

Increased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form a pore in cell membranes only when cleaved by MMPs (PA-L1). Anthrax lethal factor (LF) is then able to translocate through these pores. Read More

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http://dx.doi.org/10.2967/jnumed.119.226423DOI Listing
April 2019
1 Read

The Ser/Thr protein kinase PrkC imprints phenotypic memory in spores by phosphorylating the glycolytic enzyme enolase.

J Biol Chem 2019 Apr 5. Epub 2019 Apr 5.

Department of Zoology, University of Delhi, India.

is the causative agent of anthrax in humans, bovine, and other animals. pathogenesis requires differentiation of dormant spores into vegetative cells. The spores inherit cellular components as phenotypic memory from the parent cell, and this memory plays a critical role in facilitating the spores' revival. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.005424
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http://dx.doi.org/10.1074/jbc.RA118.005424DOI Listing
April 2019
1 Read

Multiporous Terbium Phosphonate Coordination Polymer Microspheres as Fluorescent Probes for Trace Anthrax Biomarker Detection.

ACS Appl Mater Interfaces 2019 Apr 17. Epub 2019 Apr 17.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai 200237 , China.

Lanthanide coordination polymers have been recently regarded as attractive sensing materials because of their selectivity, high sensitivity, and rapid response ability. In this research, the multiporous terbium phosphonate coordination polymer microspheres (TbP-CPs) were prepared as a novel fluorescent probe, which showed a fluorescence turn-on response capability for the detection of the trace anthrax biomarker dipicolinate acid (DPA). The morphology and chemical composition of as-prepared TbP-CPs were characterized in detail. Read More

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http://dx.doi.org/10.1021/acsami.9b01123DOI Listing
April 2019
6.723 Impact Factor

The putative polysaccharide deacetylase Ba0331: cloning, expression, crystallization and structure determination.

Acta Crystallogr F Struct Biol Commun 2019 Apr 3;75(Pt 4):312-320. Epub 2019 Apr 3.

Department of Biotechnology, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.

Ba0331 is a putative polysaccharide deacetylase from Bacillus anthracis, the etiological agent of the disease anthrax, that contributes to adaptation of the bacterium under extreme conditions and to maintenance of the cell shape. In the present study, the crystal structure of Ba0331 was determined at 2.6 Å resolution. Read More

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http://dx.doi.org/10.1107/S2053230X19001766DOI Listing
April 2019
1 Read

Bismaleimide cross-linked anthrax toxin forms functional octamers with high specificity in tumor targeting.

Protein Sci 2019 Apr 3. Epub 2019 Apr 3.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.

In recent years, anthrax toxin has been reengineered to act as a highly specific antiangiogenic cancer therapeutic, shown to kill tumors in animal models. This has been achieved by modifying protective antigen (PA) so that its activation and toxicity require the presence of two proteases, matrix metalloproteinase (MMP) and urokinase plasminogen activator (uPA), which are upregulated in tumor microenvironments. These therapeutics consist of intercomplementing PA variants, which are individually nontoxic, but form functional toxins upon complementary oligomerization. Read More

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http://dx.doi.org/10.1002/pro.3613DOI Listing

A Bivalent Protein r-PAbxpB Comprising PA Domain IV and Exosporium Protein BxpB Confers Protection Against Spores and Toxin.

Front Immunol 2019 19;10:498. Epub 2019 Mar 19.

School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.

Anthrax vaccines primarily relying only on protective antigen (PA), the cell binding component in anthrax toxins provide incomplete protection when challenged with spores of virulent encapsulated strains. Alternatively, formaldehyde inactivated spores (FIS) or recombinant spore components generate anti-spore immune responses that inhibit the early stages of infection and augment the PA protective efficacy. In the present study domain IV of PA was spliced with exosporium antigen BxpB via a flexible G4S linker to generate a single functional antigen r-PAbxpB that was further assessed for its protective efficacy against anthrax toxins and spore infection. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433990PMC
March 2019
1 Read

Comparative genomics and phylogenetic analysis of Bacillus anthracis strains isolated from domestic animals in Japan.

Infect Genet Evol 2019 Mar 27;71:128-139. Epub 2019 Mar 27.

Department of Veterinary Science, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Electronic address:

Anthrax, caused by Bacillus anthracis, is a severe zoonosis with a great impact on both human and animal health. In the present study, we identified the phylogenetic relationships among 16 Japanese strains of B. anthracis, including eight bovine strains, two equine strains, five swine strains, and one former vaccine strain, using in silico canonical single nucleotide polymorphism (canSNP) and core genome SNP analyses. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.03.022DOI Listing
March 2019
1 Read

Duclaux, Chamberland, Roux, Grancher, and Metchnikoff: the five musketeers of Louis Pasteur.

Genes Immun 2019 Mar 29. Epub 2019 Mar 29.

Centre de ressources en information scientifique, Institut Pasteur, Paris, France.

The Institut Pasteur was created, thanks to worldwide generosity with the aim to welcome and treat rabies patients, to provide a place for scientific research and to offer new teaching programs in microbiology. Louis Pasteur invited his main collaborators, who had accompanied him during his previous investigations at École Normale Supérieure, to join him in his new institute. They contributed to the principle discoveries of Pasteur, such as the fight against spontaneous generation, the identification of the ferments of putrefaction, the fight against the silk worm disease, the research on wine and beer, and the set-up of the first vaccines against avian cholera, anthrax, swine erysipelas, and rabies. Read More

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http://dx.doi.org/10.1038/s41435-019-0064-1DOI Listing
March 2019
1 Read

Risk mapping and eco-anthropogenic assessment of anthrax in the upper Zambezi basin.

Vet Med Sci 2019 Mar 28. Epub 2019 Mar 28.

Department of Disease Control, School of Veterinary Medicine, The University of Zambia, Lusaka, Zambia.

In Zambia, anthrax has emerged as a serious disease decimating humans, livestock and wildlife with devastating effects on eco-tourism resulting in the destabilization of major pristine wildlife sanctuaries. Consequently, the thrust of this study was to establish the spatial distribution of anthrax and determine ecological drivers of its recurrence, maintenance and epidemiological linkage to anthropogenic activities. Environmental and biological samples were collected within the livestock production and conservation areas (n = 80). Read More

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http://dx.doi.org/10.1002/vms3.168DOI Listing
March 2019
1 Read

Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax.

Anal Bioanal Chem 2019 May 26;411(12):2493-2509. Epub 2019 Mar 26.

Centers for Disease Control and Prevention, 4770 Buford Highway Mailstop F-50, Atlanta, GA, 30341, USA.

Inhalation of Bacillus anthracis spores can cause a rapidly progressing fatal infection. B. anthracis secretes three protein toxins: lethal factor (LF), edema factor (EF), and protective antigen (PA). Read More

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http://dx.doi.org/10.1007/s00216-019-01730-4DOI Listing
May 2019
1 Read

A detailed review of the mosquitoes (Diptera: Culicidae) of Iran and their medical and veterinary importance.

Acta Trop 2019 Mar 18;194:106-122. Epub 2019 Mar 18.

Department of Life Sciences, Natural History Museum, London, UK.

Mosquitoes (Diptera: Culicidae) are the most significant arthropods of medical importance because of the burden of diseases, such as malaria, encephalitis and filariasis, which are caused by pathogens and parasites they transmit to humans. In 2007, the most recently published checklist of Iranian mosquitoes included 64 species representing seven genera. Public databases were searched to the end of August 2018 for publications concerning the diseases in Iran caused by mosquito-borne pathogens. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.03.019DOI Listing
March 2019
1 Read

Development and Performance of a Checklist for Initial Triage After an Anthrax Mass Exposure Event.

Ann Intern Med 2019 Mar 19. Epub 2019 Mar 19.

Centers for Disease Control and Prevention, Atlanta, Georgia (M.P., R.M.T., W.A.B., K.H.).

Background: Population exposure to Bacillus anthracis spores could cause mass casualties requiring complex medical care. Rapid identification of patients needing anthrax-specific therapies will improve patient outcomes and resource use.

Objective: To develop a checklist that rapidly distinguishes most anthrax from nonanthrax illnesses on the basis of clinical presentation and identifies patients requiring diagnostic testing after a population exposure. Read More

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http://dx.doi.org/10.7326/M18-1817DOI Listing
March 2019
2 Reads

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes.

Science 2019 04 14;364(6435). Epub 2019 Mar 14.

Division of Immunology and Pathogenesis, Department of Molecular & Cell Biology, and Cancer Research Laboratory, University of California, Berkeley, CA, USA.

Inflammasomes are multiprotein platforms that initiate innate immunity by recruitment and activation of caspase-1. The NLRP1B inflammasome is activated upon direct cleavage by the anthrax lethal toxin protease. However, the mechanism by which cleavage results in NLRP1B activation is unknown. Read More

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http://dx.doi.org/10.1126/science.aau1330DOI Listing

N-terminal degradation activates the NLRP1B inflammasome.

Science 2019 04 14;364(6435):82-85. Epub 2019 Mar 14.

Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Intracellular pathogens and danger signals trigger the formation of inflammasomes, which activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors both activate the NLRP1B inflammasome, but the molecular mechanism of NLRP1B activation is unknown. In this study, we used genome-wide CRISPR-Cas9 knockout screens to identify genes required for NLRP1B-mediated pyroptosis. Read More

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http://dx.doi.org/10.1126/science.aau1208DOI Listing
April 2019
4 Reads

Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling.

Int J Mol Sci 2019 Mar 7;20(5). Epub 2019 Mar 7.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

The Edema Toxin (ET), composed of a Protective Antigen (PA) and the Edema Factor (EF), is a cellular adenylate cyclase that alters host responses by elevating cyclic adenosine monophosphate (cAMP) to supraphysiologic levels. However, the role of ET in systemic anthrax is unclear. Efferocytosis is a cAMP-sensitive, anti-inflammatory process of apoptotic cell engulfment, the inhibition of which may promote sepsis in systemic anthrax. Read More

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http://dx.doi.org/10.3390/ijms20051167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429438PMC
March 2019
4 Reads

The elephant-livestock interface modulates anthrax suitability in India.

Proc Biol Sci 2019 Mar;286(1898):20190179

5 Prasanna School of Public Health, Manipal Academy of Higher Education , Manipal, Karnataka , India.

Anthrax is a potentially life-threatening bacterial disease that can spread between wild and livestock animals and humans. Transmission typically occurs indirectly via environmental exposure, with devastating consequences for human and animal health, as well as pastoralist economies. India has a high annual occurrence of anthrax in some regions, but a country-wide delineation of risk has not yet been undertaken. Read More

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http://www.royalsocietypublishing.org/doi/10.1098/rspb.2019.
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http://dx.doi.org/10.1098/rspb.2019.0179DOI Listing
March 2019
7 Reads

Investigation of anthrax in an endemic region in Kenya: a mixed methods approach.

Pan Afr Med J 2018 18;30(Suppl 1):12. Epub 2018 May 18.

Kenya Field Epidemiology and Laboratory Training Program, Kenya.

In Kenya, human anthrax cases most often occur linked to animal anthrax. In most cases, human behaviors, especially slaughter and consumption of meat from animal anthrax cases, has been implicated. This case study is based on an anthrax outbreak investigation conducted in an endemic region in Kenya in May 2016. Read More

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http://dx.doi.org/10.11604/pamj.supp.2018.30.1.15279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379556PMC
March 2019
1 Read

spp. in bovine milk: An emerging pathogen with potential zoonotic risk.

Ital J Food Saf 2018 Dec 8;7(4):7685. Epub 2019 Feb 8.

Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Foggia.

The aim of the present study was to assess the prevalence and genetic characteristics of spp. in bovine bulk tank milk produced in Apulia Region (Italy). Samples collected from 396 dairy farms, after enrichment in a selective broth, were subjected to an genus - specific Real Time PCR. Read More

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http://dx.doi.org/10.4081/ijfs.2018.7685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379690PMC
December 2018

The PlyB Endolysin of Bacteriophage vB_BanS_Bcp1 Exhibits Broad-Spectrum Bactericidal Activity against Isolates.

Appl Environ Microbiol 2019 May 18;85(9). Epub 2019 Apr 18.

Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA

Lytic bacteriophages (or phages) drive bacterial mortality by elaborating exquisite abilities to bind, breach, and destroy bacterial cell membranes and subjugate critical bacterial cell functions. These antimicrobial activities make phages ideal candidates to serve as, or provide sources of, biological control measures for bacterial pathogens. In this study, we isolated the phage vB_BanS_Bcp1 (here referred to as Bcp1) from landfill soil, using a host. Read More

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http://dx.doi.org/10.1128/AEM.00003-19DOI Listing

Risk factors for human cutaneous anthrax outbreaks in the hotspot districts of Northern Tanzania: an unmatched case-control study.

R Soc Open Sci 2018 Sep 5;5(9):180479. Epub 2018 Sep 5.

Faculty of Veterinary Medicine, Norwegian University of Life Sciences, PO Box 8146 Dep., 0033 Oslo, Norway.

is an aerobic, Gram-positive and spore-forming bacterium, which causes anthrax in herbivores. Humans get infected after coming into contact with infected animals' products. An unmatched case-control study was conducted to identify the importance of demographic, biological and/or behavioural factors associated with human cutaneous anthrax outbreaks in the hotspot areas of Northern Tanzania. Read More

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http://dx.doi.org/10.1098/rsos.180479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170534PMC
September 2018
3 Reads

Distinct Contribution of the HtrA Protease and PDZ Domains to Its Function in Stress Resilience and Virulence of .

Front Microbiol 2019 18;10:255. Epub 2019 Feb 18.

Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel.

Anthrax is a lethal disease caused by the Gram-positive spore-producing bacterium . We previously demonstrated that disruption of gene, encoding the chaperone/protease HtrA (High Temperature Requirement A of ) results in significant virulence attenuation, despite unaffected ability of Δ strains (in which the gene was deleted) to synthesize the key anthrax virulence factors: the exotoxins and capsule. Δ strains exhibited increased sensitivity to stress regimens as well as silencing of the secreted starvation-associated Neutral Protease A (NprA) and down-modulation of the bacterial S-layer. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387919PMC
February 2019
2 Reads

Fatal community-acquired Bacillus cereus pneumonia in an immunocompetent adult man: a case report.

BMC Infect Dis 2019 Feb 27;19(1):197. Epub 2019 Feb 27.

Department of Emergency and Critical Care Medicine, Shimane Prefectural Central Hospital, 4-1-1 Himebara, Izumo, Shimane, 693-8555, Japan.

Background: Bacillus cereus is a gram-positive rod bacterium that is responsible for food poisoning. It is naturally widely distributed, and thus often contaminates cultures. Although it is rarely considered responsible, it can cause serious infections under certain conditions. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3836-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391836PMC
February 2019
4 Reads

Accurate and selective quantification of anthrax protective antigen in plasma by immunocapture and isotope dilution mass spectrometry.

Analyst 2019 Mar;144(7):2264-2274

Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA.

Anthrax protective antigen (83 kDa, PA83) is an essential component of two major binary toxins produced by Bacillus anthracis, lethal toxin (LTx) and edema toxin (ETx). During infection, LTx and ETx contribute to immune collapse, endothelial dysfunction, hemorrhage and high mortality. Following protease cleavage on cell receptors or in circulation, the 20 kDa (PA20) N-terminus is released, activating the 63 kDa (PA63) form which binds lethal factor (LF) and edema factor (EF), facilitating their entry into their cellular targets. Read More

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http://dx.doi.org/10.1039/c8an02479kDOI Listing

Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma.

Front Med (Lausanne) 2019 12;6:22. Epub 2019 Feb 12.

Centre for Advanced Imaging (CAI), The University of Queensland, Brisbane, QLD, Australia.

Squamous cell carcinoma (SCC) accounts for the majority of non-melanoma skin cancer related deaths, particularly in immunosuppressed persons. Identification of biomarkers that could be used to identify or treat SCC would be of significant benefit. The anthrax toxin receptors, Tumor Endothelial Marker 8 (TEM8) and Capillary Morphogenesis Gene 2 (CMG2), are endothelial receptors involved in extracellular matrix homeostasis and angiogenesis that are selectively upregulated on numerous tumors. Read More

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http://dx.doi.org/10.3389/fmed.2019.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379334PMC
February 2019
1 Read

Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression.

Theranostics 2019 21;9(3):620-632. Epub 2019 Jan 21.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Endometriosis is a highly prevalent gynecological disease in women of reproductive age that markedly reduces life quality and fertility. Unfortunately, there is no cure for this disease, which highlights that more efforts are needed to investigate the underlying mechanism for designing novel therapeutic regimens. This study aims to investigate druggable membrane receptors distinctively expressed in endometriotic cells. Read More

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http://dx.doi.org/10.7150/thno.30655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376465PMC
January 2019
2 Reads

Detection of Bacillus anthracis in animal tissues using InBios active anthrax detect rapid test lateral flow immunoassay.

Lett Appl Microbiol 2019 Feb 18. Epub 2019 Feb 18.

Centers for Disease Control and Prevention, Atlanta, GA, USA.

The Active Anthrax Detect (AAD) Rapid Test lateral flow immunoassay is a point-of-care assay that was under investigational use for detecting Bacillus anthracis capsular polypeptide (polyglutamic acid) in human blood, serum and plasma. Small sample volumes, rapid results and no refrigeration required allow for easy use in either the field or laboratory. Although the test was developed for use in suspect cases of human inhalation anthrax, its features also make it a potentially powerful tool for testing suspect animal cases. Read More

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http://doi.wiley.com/10.1111/lam.13134
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http://dx.doi.org/10.1111/lam.13134DOI Listing
February 2019
12 Reads

Single dose of DPX-rPA, an enhanced-delivery anthrax vaccine formulation, protects against a lethal spore inhalation challenge.

NPJ Vaccines 2019 8;4. Epub 2019 Feb 8.

IMV Inc., 130 Eileen Stubbs Avenue, Suite 19, Dartmouth, NS B3B 2C4 Canada.

Anthrax is a serious biological threat caused by pulmonary exposure to aerosolized spores of . Biothrax (anthrax vaccine adsorbed (AVA)) is the only Food and Drug Administration-licensed vaccine and requires five administrations over 12 months with annual boosting to maintain pre-exposure prophylaxis. Here we report the evaluation of a single intramuscular injection of recombinant -protective antigen (rPA) formulated in the DPX delivery platform. Read More

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http://dx.doi.org/10.1038/s41541-019-0102-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368554PMC
February 2019
2 Reads

B. anthracis Lethal Toxin but not Edema Toxin, Increases Pulmonary Artery Pressure and Permeability in Isolated Perfused Rat Lungs.

Am J Physiol Heart Circ Physiol 2019 Feb 15. Epub 2019 Feb 15.

Critical Care Medicine Department, National Institutes of Health, United States.

Introduction: Although lethal (LT) and edema toxin (ET) contribute to lethality during Bacillus anthracis infection, whether they increase vascular permeability and the extravascular fluid accumulation characterizing this infection is unclear. We employed an isolated perfused Sprague-Dawley rat lung model to investigate LT and ETs effects on pulmonary vascular permeability.

Methods And Results: Lungs (n≥6 per experimental group) were isolated, ventilated, suspended from a force transducer and perfused. Read More

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http://dx.doi.org/10.1152/ajpheart.00685.2018DOI Listing
February 2019
3.838 Impact Factor

[Update of knowledge on Neglected Diseases in Haiti: Mansonelliasis, Tungiasis, Leprosy, and Anthrax].

Bull Soc Pathol Exot 2018 ;111(1):17-23

Direction d'épidémiologie, de laboratoire et de recherches, 52 angle Delmas 33 et rue Charbonnières, Port-au-Prince, Haïti.

Haiti, like most limited-resources countries in the world, faces numerous neglected infectious diseases. They represent a real public health issue with lethal consequences especially in children. We are reviewing here the available literature on four neglected infectious diseases, mansonelliasis, tungiasis, leprosy and anthrax. Read More

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http://dx.doi.org/10.3166/bspe-2018-0005DOI Listing
January 2018
1 Read

Cutaneous Anthrax Outbreak in the Trakya Region of Turkey

Balkan Med J 2019 01 31. Epub 2019 Jan 31.

Department of Infectious Diseases, Trakya University School of Medicine, Edirne, Turkey

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http://dx.doi.org/10.4274/balkanmedj.galenos.2019.2018.12.19DOI Listing
January 2019

Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication.

FASEB J 2019 Apr 30;33(4):5755-5771. Epub 2019 Jan 30.

Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany.

The antibiotic bacitracin (Bac) inhibits cell wall synthesis of gram-positive bacteria. Here, we discovered a totally different activity of Bac: the neutralization of bacterial exotoxins. Bac prevented intoxication of mammalian cells with the binary enterotoxins Clostridium botulinum C2, C. Read More

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http://dx.doi.org/10.1096/fj.201802453RDOI Listing
April 2019
3 Reads

Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives.

Mol Divers 2019 Jan 29. Epub 2019 Jan 29.

Jiangsu Key Laboratory of Pesticide, College of Sciences, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.

We synthesized a series of novel pyrrole- and pyrazole-substituted coumarin derivatives and evaluated their antifungal activity against six phytopathogenic fungi in vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds 5g, 6a, 6b, 6c, 6d and 6h exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Read More

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http://dx.doi.org/10.1007/s11030-019-09920-zDOI Listing
January 2019
1 Read
1.896 Impact Factor

Role of ANTXR1 in the regulation of RANKL-induced osteoclast differentiation and function.

Biochem Biophys Res Commun 2019 Mar 25;510(2):296-302. Epub 2019 Jan 25.

Division of Rheumatology, Department of Internal Medicine, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk, 570-749, Republic of Korea. Electronic address:

Anthrax toxin receptor 1 (ANTXR1) is a transmembrane protein with an extracellular domain which is deeply associated with the process of bone formation and plays an important role in angiogenesis. However, there have been no reports investigating the effects of ANTXR1 on bone metabolism mediated by the two types of bone cells, osteoclasts, and osteoblasts. The aim of this study is to reveal the role of ANTXR1 in the differentiation and function of osteoclasts and osteoblasts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X193011
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http://dx.doi.org/10.1016/j.bbrc.2019.01.094DOI Listing
March 2019
10 Reads

A participatory epidemiological study of major cattle diseases amongst Maasai pastoralists living in wildlife-livestock interfaces in Maasai Mara, Kenya.

Trop Anim Health Prod 2019 Jan 25. Epub 2019 Jan 25.

International Livestock Research Institute, (ILRI), P. O BOX 30709, Nairobi, 00100, Kenya.

Livestock-wildlife interactions promote the transmission of a wide range of infectious diseases that constraint livestock production. We used a participatory appraisal approach to find out and rank infectious diseases of concern to pastoralists in a zone of intense wildlife-livestock interaction and another zone with limited interactions. Four villages were selected purposively in areas with intensive cattle-wildlife interactions (zone 1), and another two in areas with low to moderate cattle-wildlife interactions (zone 2). Read More

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http://dx.doi.org/10.1007/s11250-018-01790-1DOI Listing
January 2019
2 Reads

Development of a novel multiepitope chimeric vaccine against anthrax.

Med Microbiol Immunol 2019 Apr 22;208(2):185-195. Epub 2019 Jan 22.

Laboratory of Molecular Biology and Genetic Engineering, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.

Bacillus anthracis (BA), the etiological agent of anthrax, secretes protective antigen (PA), lethal factor (LF), and edema factor (EF) as major virulence mediators. Amongst these, PA-based vaccines are most effective for providing immunity against BA, but their low shelf life limits their usage. Previous studies showed that B-cell epitopes, ID II and ID III present in PA domain IV possess higher toxin neutralization activity and elicit higher antibody titer than ID I. Read More

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http://dx.doi.org/10.1007/s00430-019-00577-xDOI Listing
April 2019
1 Read

Genome sequence of Bacillus anthracis typing phage AP631.

Arch Virol 2019 Mar 21;164(3):917-921. Epub 2019 Jan 21.

State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing, 100071, China.

AP631, a virulent bacteriophage of Bacillus anthracis, is widely used in China to identify anthrax bacteria. In this study, we report the complete AP631 phage genome sequence as well as comparative genomic analysis with other bacteriophages of B. cereus and related species. Read More

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http://dx.doi.org/10.1007/s00705-018-04135-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394722PMC
March 2019
3 Reads

Systematic mutational analysis of human neutrophil α-defensin HNP4.

Biochim Biophys Acta Biomembr 2019 Apr 15;1861(4):835-844. Epub 2019 Jan 15.

Institute of Human Virology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, USA.

Defensins are a family of cationic antimicrobial peptides of innate immunity with immunomodulatory properties. The prototypic human α-defensins, also known as human neutrophil peptides 1-3 or HNP1-3, are extensively studied for their structure, function and mechanisms of action, yet little is known about HNP4 - the much less abundant "distant cousin" of HNP1-3. Here we report a systematic mutational analysis of HNP4 with respect to its antibacterial activity against E. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.01.007DOI Listing
April 2019
15 Reads
3.836 Impact Factor

Genome Sequences of Penicillin-Resistant Bacillus anthracis Strains.

Microbiol Resour Announc 2019 Jan 10;8(2). Epub 2019 Jan 10.

Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Bacillus anthracis, the etiologic agent of anthrax, is characteristically susceptible to penicillin despite containing two chromosomal β-lactamase genes. Few naturally occurring penicillin-resistant B. anthracis isolates have been reported. Read More

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http://genomea.asm.org/lookup/doi/10.1128/MRA.01122-18
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http://dx.doi.org/10.1128/MRA.01122-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328647PMC
January 2019
11 Reads

Tale of 2 Orifices.

Circ Cardiovasc Imaging 2019 Dec;12(1):e008372

Leon H Charney Division of Cardiology (A.F.V., M.S.), New York University Langone Medical Center.

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008372DOI Listing
December 2019
7 Reads

An ELISA using a recombinant chimera of protective antigen and lethal factor for serodiagnosis of cutaneous anthrax in India.

Biologicals 2019 Jan 8;57:55-60. Epub 2019 Jan 8.

Defence Research & Development Establishment, Jhansi Road, Gwalior, 474 002, India. Electronic address:

In this study, an ELISA was developed for simultaneous detection of antibodies against both the important toxins of B. anthracis i.e. Read More

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http://dx.doi.org/10.1016/j.biologicals.2019.01.001DOI Listing
January 2019
2 Reads
1.209 Impact Factor

A new triple chimeric protein as a high immunogenic antigen against anthrax toxins: theoretical and experimental analyses.

Immunopharmacol Immunotoxicol 2019 Jan 9:1-7. Epub 2019 Jan 9.

b Faculty of Biological Sciences , Tarbiat Modares University , Tehran , Iran.

Background: Anthrax is a zoonotic disease caused by Bacillus anthracis and it can be deadly in 6 days. Considerable efforts have been conducted toward developing more effective veterinary and human anthrax vaccines because these common vaccines have several limitations. B. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1510419DOI Listing
January 2019
13 Reads
1.109 Impact Factor

Europium functionalized silicon quantum dots nanomaterials for ratiometric fluorescence detection of Bacillus anthrax biomarker.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 21;212:88-93. Epub 2018 Dec 21.

College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, PR China. Electronic address:

Bacillus anthracis spore causes anthrax to seriously threaten human health and even cause death. 2,6-Pyridinedicarboxylic acid (DPA) is a unique biomarker because it is a major component of Bacillus anthracis spore. Herein, we design europium functionalized silicon quantum dots as a ratiometric fluorescent nanoprobe to detect DPA with high sensitivity and selectivity. Read More

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http://dx.doi.org/10.1016/j.saa.2018.12.036DOI Listing
April 2019
1 Read

Bacillus species at the Canberra Airport: A comparison of real-time polymerase chain reaction and massively parallel sequencing for identification.

Forensic Sci Int 2019 Feb 21;295:169-178. Epub 2018 Dec 21.

National Centre for Forensic Studies, University of Canberra, Bruce, ACT, 2617, Australia; Centre for Forensic Science, School of Mathematical & Physical Sciences (MaPS), Faculty of Science, University of Technology Sydney, Broadway, NSW, 2007, Australia. Electronic address:

Anthrax, caused by the Gram-positive, spore forming bacterium Bacillus anthracis, is a disease with naturally occurring outbreaks in many parts of the world, primarily in domestic and wild herbivores. Due to the movement of people and stock, B. anthracis could, however, be at transportation hubs including airports. Read More

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http://dx.doi.org/10.1016/j.forsciint.2018.12.011DOI Listing
February 2019
2 Reads

Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes.

Proc Natl Acad Sci U S A 2019 01 4;116(4):1279-1288. Epub 2019 Jan 4.

Global Health Institute, Faculty of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

The protein acyl transferase ZDHHC5 was recently proposed to regulate trafficking in the endocytic pathway. Therefore, we explored the function of this enzyme in controlling the action of bacterial toxins. We found that ZDHHC5 activity is required for two very different toxins: the anthrax lethal toxin and the pore-forming toxin aerolysin. Read More

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http://dx.doi.org/10.1073/pnas.1812588116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347675PMC
January 2019
7 Reads

Evolutionary Features in the Structure and Function of Bacterial Toxins.

Toxins (Basel) 2019 Jan 3;11(1). Epub 2019 Jan 3.

Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA 02747, USA.

Toxins can function both as a harmful and therapeutic molecule, depending on their concentrations. The diversity in their function allows us to ask some very pertinent questions related to their origin and roles: (a) What makes them such effective molecules? (b) Are there evolutionary features encoded within the structures of the toxins for their function? (c) Is structural hierarchy in the toxins important for maintaining their structure and function? (d) Do protein dynamics play a role in the function of toxins? and (e) Do the evolutionary connections to these unique features and functions provide the fundamental points in driving evolution? In light of the growing evidence in structural biology, it would be appropriate to suggest that protein dynamics and flexibility play a much bigger role in the function of the toxin than the structure itself. Discovery of IDPs (intrinsically disorder proteins), multifunctionality, and the concept of native aggregation are shaking the paradigm of the requirement of a fixed three-dimensional structure for the protein's function. Read More

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http://www.mdpi.com/2072-6651/11/1/15
Publisher Site
http://dx.doi.org/10.3390/toxins11010015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356308PMC
January 2019
22 Reads
2.480 Impact Factor

A therapeutic human antibody against the domain 4 of the Bacillus anthracis protective antigen shows protective efficacy in a mouse model.

Biochem Biophys Res Commun 2019 Feb 31;509(2):611-616. Epub 2018 Dec 31.

Division of High-risk Pathogens, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, 28159, South Korea. Electronic address:

Since Bacillus anthracis is a high-risk pathogen and a potential tool for bioterrorism, numerous therapeutic methods including passive immunization have been actively developed. Using a human monoclonal antibody phage display library, we screened new therapeutic antibodies for anthrax infection against protective antigen (PA) of B. anthracis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183281
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http://dx.doi.org/10.1016/j.bbrc.2018.12.146DOI Listing
February 2019
14 Reads

Mapping the epidemiological distribution and incidence of major zoonotic diseases in South Tigray, North Wollo and Ab'ala (Afar), Ethiopia.

PLoS One 2018 31;13(12):e0209974. Epub 2018 Dec 31.

College of Veterinary Medicine, Mekelle University, Mekelle, Ethiopia.

Zoonotic diseases continue to affect the health and livelihood of resource limited communities. In Ethiopia, despite the presence of a national master plan for prevention, control and elimination of some common zoonotic diseases, well-organized epidemiological data regarding incidence and distribution are lacking. A retrospective cross-sectional study based on a patient medical data recorded from 2012-2016 in selected districts of Southern Tigray, North Wollo zone of Amhara region and Ab'Ala district of Afar region was conducted to map the distribution and Incidence proportion of major zoonotic diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209974PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312287PMC
December 2018
3 Reads