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Retin Cases Brief Rep 2022 Mar 23. Epub 2022 Mar 23.

Philadelphia Retina Associates, 2701 Holme Avenue, Suite 303, Philadelphia, PA 19152.

Purpose: Describe a case of severe occlusive vasculitis that led to a diagnosis of acquired immunodeficiency syndrome (AIDS) in a previously healthy middle-aged man.

Methods: Multimodal imaging including widefield fundus photography, spectral domain optical coherence tomography (OCT), and widefield fluorescein angiography (FA).

Results: A healthy 46-year-old man presented with sudden onset vision loss in his left eye with an afferent pupillary defect. Read More

Front Med (Lausanne) 2022 9;9:796667. Epub 2022 Feb 9.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Qingdao, China.

Purpose: To observe and analyze the clinical and multi-mode imaging features of eyes with PHOMS, and to introduce two cases of PHOMS which underwent multi-mode imaging.

Methods: Retrospective clinical observational study. A total of 26 patients (37 eyes) with hyperreflective structures surrounded by hyporeflective edges around the optic discs who were examined and diagnosed at Shandong Eye Hospital between January 2019 and June 2021 were included in the study. Read More

Beyoglu Eye J 2021 18;6(1):74-78. Epub 2021 Feb 18.

Department of Ophthalmology, Istanbul Health Sciences University, Bagcilar Training and Research Hospital, Istanbul, Turkey.

Presently described is a case of fungal septicemia diagnosed based on a fundus examination and successfully treated with voriconazole. A 48-year-old woman who had undergone sleeve gastrectomy 20 days prior due to obesity was referred to the ophthalmology clinic for blurred vision in the right eye. The initial examination indicated visual acuity of only light perception in the right eye and 0. Read More

Dis Markers 2021 26;2021:6575195. Epub 2021 Dec 26.

Department of Ophthalmology, The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: The vitreous body is an important part of the ocular body fluid. A foldable capsular vitreous body (FCVB) is designed to treat chronic adverse complications in severe ocular trauma and silicone oil-dependent eyes. This study is aimed at investigating a method for implanting an FCVB, its postoperative efficacy, and clinical value. Read More

BMC Ophthalmol 2021 Oct 5;21(1):353. Epub 2021 Oct 5.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100 Haining Rd., Shanghai, 200080, China.

Background: The aim of this study is to identify the genetic defect in a Chinese family with congenital aniridia combined with cataract and nystagmus.

Methods: Complete ophthalmic examinations, including slit-lamp biomicroscopy, dilated indirect ophthalmoscopy, anterior segment photography, and anterior segment optical coherence tomography (OCT) were performed. Blood samples were collected from all family members and genomic DNA was extracted. Read More

Asia Pac J Ophthalmol (Phila) 2021 Sep-Oct 01;10(5):461-472

Columbia University Medical Center, New York, NY, US.

Purpose: To examine the benefits and feasibility of a mobile, real-time, community-based, teleophthalmology program for detecting eye diseases in the New York metro area.

Design: Single site, nonrandomized, cross-sectional, teleophthalmologic study.

Methods: Participants underwent a comprehensive evaluation in a Wi-Fi-equipped teleophthalmology mobile unit. Read More

Biomed Opt Express 2021 Jul 23;12(7):4380-4400. Epub 2021 Jun 23.

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

Subretinal fibrosis is one of the most prevalent causes of blindness in the elderly population, but a true gold standard to objectively diagnose fibrosis is still lacking. Since fibrotic tissue is birefringent, it can be detected by polarization-sensitive optical coherence tomography (PS-OCT). We present a new algorithm to automatically detect, segment, and quantify fibrotic lesions within 3D data sets recorded by PS-OCT. Read More

Transl Vis Sci Technol 2021 08;10(9):20

PriMed Non-human Primate Research Center of Sichuan PriMed Shines Bio-tech Co., Ltd., Ya'an, Sichuan Province, China.

Purpose: To describe the ocular phenotype of spontaneous glaucoma in a non-human primate colony.

Methods: In total, 722 Rhesus macaque monkeys aged 10 to 25 years underwent optical coherence tomography (OCT), fundus photography (FP), and intraocular pressure (IOP) measurements. Monkeys with baseline cup-to-disc ratio (CDR) <0. Read More

J Ophthalmic Vis Res 2021 Jul-Sep;16(3):357-366. Epub 2021 Jul 29.

Department of Ophthalmology, Government Medical College and Hospital, Sector-32, Chandigarh, India.

Purpose: Ophthalmology has seen numerous novel uses for smartphones over the years including fundus photography, telemedicine, and operative videography. However, anterior segment photography for assessing and documenting trabeculectomy bleb morphology using a smartphone has not been explored in detail. With the current study, we aim to characterize ideal illumination for the anterior segment smartphone photography in trabeculectomy patients. Read More

Invest Ophthalmol Vis Sci 2021 06;62(7):27

Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.

Purpose: The purpose of this study was to characterize the phenotypic spectrum of ophthalmic findings in patients with Alagille syndrome.

Methods: We conducted a retrospective, observational, multicenter, study on 46 eyes of 23 subjects with Alagille syndrome. We reviewed systemic and ophthalmologic data extracted from medical records, color fundus photography, fundus autofluorescence, optical coherence tomography, visual fields, electrophysiological assessments, and molecular genetic findings. Read More

Transl Vis Sci Technol 2021 05;10(6)

Department of Ophthalmology & Vision Science, School of Medicine, University of California-Davis, Sacramento, CA, USA.

Purpose: To determine the range of normal ocular biometry and perform advanced retinal imaging and functional assessment of the rhesus macaque eye.

Methods: We performed ocular phenotyping on rhesus macaques at the California National Primate Research Center. This process consisted of anterior and posterior segment eye examination by ophthalmologists, advanced retinal imaging, and functional retinal electrophysiology. Read More

Ophthalmologica 2021 1;244(5):465-479. Epub 2021 Jun 1.

Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.

Most uveitis entities are rare diseases but, taken together, are responsible for 5-10% of worldwide visual impairment which largely affects persons of working age. As with many rare diseases, there is a lack of high-level evidence regarding its clinical management, partly due to a dearth of reliable and objective quantitative endpoints for clinical trials. This review provides an overview of available structural outcome measures for uveitis disease activity and damage in an anatomical order from the anterior to the posterior segment of the eye. Read More

Adv Ther 2021 06 21;38(6):3362-3372. Epub 2021 May 21.

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.

Introduction: The present study aimed to analyze the clinical features of ocular pathology in patients with acquired immunodeficiency syndrome (AIDS) combined with syphilis.

Methods: A total of 129 patients with AIDS and syphilis who first visited the Department of Ophthalmology in Beijing YouAn Hospital between 2012 and 2019 were included in the study. All patients underwent ophthalmologic examinations, such as best-corrected visual acuity (BCVA), slit lamp, intraocular pressure, dilated fundus examination, and color fundus photography as well as systemic examinations related to AIDS and syphilis. Read More

Retin Cases Brief Rep 2021 May 17. Epub 2021 May 17.

Department of Ophthalmology, Klinikum Chemnitz gGmbH, Flemmingstrasse 2, 09116 Chemnitz, Germany. Phone: +49 371 333 33230. Fax: +49 371 333 33223. Email: Department of Endocrinology and Diabetology, Klinikum Chemnitz gGmbH, Flemmingstrasse 2, 09116 Chemnitz, Germany. Phone: +49 371 333 33232 Fax: +49 371 333 33224. Email:

Purpose: To report ocular manifestations of aceruloplasminemia (aCP) in two adult Caucasian siblings.Methods: The ocular findings were investigated using multimodal imaging approach including color fundus photography, fluorescein angiography, autofluorescence imaging, spectral-domain optical coherence tomography.

Results: A 43-year-old woman and a 39-year-old man were diagnosed with aCP based on clinical symptoms, laboratory tests, liver biopsy and genetic examination of the ceruloplasmin gene confirming the homozygotic mutation G708S. Read More

Am J Ophthalmol Case Rep 2021 Jun 16;22:101090. Epub 2021 Apr 16.

Icahn School of Medicine at Mount Sinai and New York Eye and Ear Infirmary of Mount Sinai, Department of Ophthalmology, New York, NY, USA.

Purpose: Fundus albipunctatus is an inherited cause of congenital stationary night blindness. The objective of this report is to describe structural changes occurring in a macular phenotype of a novel RDH5 mutation producing fundus albipunctatus using high-resolution imaging. A 62-year-old male with longstanding night blindness underwent imaging and genetic evaluation. Read More

Indian J Ophthalmol 2021 May;69(5):1271-1274

Department of Vitreo-Retina, Regional Institute of Ophthalmology, Minto Ophthalmic Hospital, BMCRI, Bengaluru, Karnataka, India.

Purpose: The aim of this work was to study and document retinal changes in coronavirus disease-2019 (COVID-19) positive patients with nonsevere disease using a nonmydriatic handheld fundus camera.

Methods: A cross-sectional observational study was conducted on patients affected by COVID-19 who were admitted at our center. Our study included patients with no, mild, and moderate symptoms (nonsevere cases). Read More

Int Ophthalmol 2021 Aug 8;41(8):2711-2722. Epub 2021 Apr 8.

Medical Research Foundation, Shri Bhagwan Mahavir Vitreo-Retinal Services, Sankara Nethralaya, 18 College Road, Chennai, 600006, Tamilnadu, India.

Purpose: To characterize the imaging features in eyes with vitreoretinal lymphoma (VRL) using ultra-widefield fundus photography (UWF-FP), swept-source optical coherence tomography (SSOCT) and fundus autofluorescence (FAF) that are correlated to ongoing treatment with intravitreal Rituximab(IVR).

Methods: Retrospective observational imaging-based study of 15 treatment-naive eyes with VRL treated with IVR. All patients with primary VRL underwent vitreous biopsy using 23/25G microincision vitrectomy system for confirmation of diagnosis. Read More

Indian J Ophthalmol 2021 04;69(4):812-823

Srimati Kanuri Santhamma Center for Vitreo-Retina Diseases, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Recent decade has seen a shift in the causes of childhood blinding diseases from anterior segment to retinal disease in both developed and developing countries. The common retinal disorders are retinopathy of prematurity and vitreoretinal infections in neonates, congenital anomalies in infants, and vascular retinopathies including type 1 diabetes, tumors, and inherited retinal diseases in children (up to 12 years). Retinal imaging helps in diagnosis, management, follow up and prognostication in all these disorders. Read More

Semin Ophthalmol 2021 May 23;36(4):185-190. Epub 2021 Feb 23.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

: Ultra-widefield (UWF) imaging of the myopic eye. : Myopes, and particularly high and pathologic myopes, present a unique challenge in fundoscopic imaging. Critical pathology is often located in the anteriormost portion of the retina, variations in posterior segment contour are difficult to capture in two-dimensional images, and extremes in axial length make simply focusing imaging devices difficult. Read More

Cornea 2021 Dec;40(12):1519-1524

Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom.

Purpose: To investigate whether transvascular indocyanine green (ICG) dye leakage is associated with conjunctival malignancy.

Methods: This is a prospective interventional study. Patients presenting with circumscribed conjunctival melanocytic disorders (CMDs) were included and examined using color photography, anterior segment optical coherence tomography to measure lesion size, and fluorescein and ICG angiography to measure vascular pattern and leakage. Read More

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Feb;38(2):170-173

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan 640041, China. cn.

Objective: To explore the genetic basis for a child with ocular anomaly, microcephaly, growth retardation and intrauterine growth restriction.

Methods: The patient underwent ophthalmologic examinations including anterior segment photography, fundus color photography, and fundus fluorescein angiography. The patient and her parents were subjected to whole exome sequencing. Read More

Open Med (Wars) 2021 19;16(1):156-160. Epub 2021 Jan 19.

Department of Pediatric Ophthalmology, Children's Memorial Health Institute, Warsaw, Poland.

Background: Cohen syndrome (Q87.8;ORPHA:193; OMIM#216550) is an autosomal recessive inherited genetic disorder caused by mutation in the gene. It is characterized by variable clinical symptoms such as deformity of the head, face, hands and feet, eye abnormalities, abdominal obesity, neutropenia and nonprogressive intellectual disability. Read More

Eur J Ophthalmol 2021 Nov 14;31(6):3463-3470. Epub 2020 Dec 14.

Department of Ophthalmology, Acibadem Hospital, Kayseri, Turkey.

Background: Optic nerve cells can be irreversibly damaged by common various causes. Unfortunately optic nerve and retinal ganglion cells have no regenerative capacity and undergo apoptosis in case of damage. In this study, our aim is to investigate the safety and efficacy of suprachoroidal umbilical cord-derived MSCs (UC-MSCs) implantation in patients with optic atrophy. Read More

Int J Stem Cells 2021 Feb;14(1):47-57

Ophthalmology Department, Kayseri Acibadem Hospital, Kayseri, Turkey.

Background And Objectives: This study shows the clinical data of 1-year follow-up of 8 patients with degenerative macular diseases who received suprachoroidal adipose tissue derived mesenchymal stem cell (ADMSC) implantation.

Methods And Results: This prospective, single-center, phase 1/2 study enrolled 8 eyes of 8 patients with degenerative macular diseases of various reasons who underwent suprachoroidal implantation of ADMSCs. All patients had severe visual field defects and severe visual loss. Read More

Am J Ophthalmol Case Rep 2020 Dec 18;20:100916. Epub 2020 Sep 18.

Doheny Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Purpose: This prospective case series investigates the visual and anatomical outcomes including detailed volumetrics of eyes with vascularized pigment epithelial detachments (PED) treated with aflibercept in eyes with neovascular age-related macular degeneration (nAMD) through meticulous analysis in a reading center setting.

Methods: We conducted a single-arm multicenter, prospective, open-labeled, interventional case series, comparing visual and anatomic outcomes at 12 months with baseline for intense aflibercept therapy. Eyes with submacular vascularized PED due to AMD received 2. Read More

Int J Ophthalmol 2020 18;13(9):1423-1429. Epub 2020 Sep 18.

Department of Ophthalmology, Kayseri Acibadem Hospital, Kayseri 38030, Turkey.

Aim: To investigate the efficacy and the safety of umbilical cord derived mesenchymal stem cell (UC-MSC) implantation in patients with retinitis pigmentosa (RP).

Methods: This prospective, single-center, phase 3 clinical study enrolled 124 eyes of 82 RP patients. The patients received 5 million UC-MSCs to the suprachoroidal area with a surgical procedure. Read More

Ophthalmic Genet 2021 02 17;42(1):71-74. Epub 2020 Sep 17.

Medical Genetics Division, Hospital de Clínicas de Porto Alegre (HCPA) , Porto Alegre, Brazil.

Background: Classic homocystinuria (HCU), or cystathionine beta-synthase (CBS) deficiency, is a rare inborn error of methionine metabolism. Main clinical features may include skeletal and vascular manifestations, developmental delay, intellectual disability and eye disorders.

Material And Methods: This is an observational and retrospective study aiming at describing eye abnormalities presented by a cohort of late-diagnosed HCU patients. Read More

Acta Diabetol 2020 Dec 4;57(12):1493-1499. Epub 2020 Aug 4.

Programa de Graduaçao em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, Sao Paulo, 01504-001, Brazil.

Aims: To evaluate diabetic retinopathy (DR) screening with a portable handheld smartphone-based retinal camera and telemedicine in an urban primary healthcare setting and to evaluate the learning curve for image acquisition, performed by healthcare personnel without previous experience in retinal imaging.

Methods: This was a prospective study that enrolled patients with type 2 diabetes mellitus (T2DM) followed at a primary healthcare unit in São Paulo, Brazil. After a brief training in image acquisition, there was further continuous feedback given by a retina specialist during the remote image reading process. Read More

Transl Vis Sci Technol 2020 02 27;9(3):30. Epub 2020 Feb 27.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California -Davis, Davis, CA, USA.

Purpose: To evaluate the safety and tolerability of a microsphere thermo-responsive hydrogel drug delivery system (DDS) loaded with aflibercept in a nonhuman primate model.

Methods: A sterile 50 µL of aflibercept-loaded microsphere thermo-responsive hydrogel-DDS (aflibercept-DDS) was injected intravitreally into the right eye of 10 healthy rhesus macaques. A complete ophthalmic examination, intraocular pressure (IOP) measurement, fundus photography, spectral-domain optical coherence tomography (SD-OCT), and electroretinogram were performed monthly for 6 months. Read More

Asia Pac J Ophthalmol (Phila) 2020 Jul-Aug;9(4):315-325

New York University (NYU Robert Grossman) School of Medicine, NYU Langone Health, New York, NY.

Purpose: The aim of this study was to assess the benefit and feasibility of the teleophthalmology GlobeChek kiosk in a community-based program.

Design: Single-site, nonrandomized, cross-sectional, teleophthalmologic study.

Methods: Participants underwent comprehensive evaluation that consists of a questionnaire form, brief systemic evaluation, screening visual field (VF), and GlobeChek kiosk screening, which included but not limited to intraocular pressure, pachymetry, anterior segment optical coherence tomography, posterior segment optical coherence tomography, and nonmydriatic fundus photography. Read More