Search Our Scientific Publications & Authors

Transl Vis Sci Technol 2021 May;10(6)

Department of Ophthalmology & Vision Science, School of Medicine, University of California-Davis, Sacramento, CA, USA.

Purpose: To determine the range of normal ocular biometry and perform advanced retinal imaging and functional assessment of the rhesus macaque eye.

Methods: We performed ocular phenotyping on rhesus macaques at the California National Primate Research Center. This process consisted of anterior and posterior segment eye examination by ophthalmologists, advanced retinal imaging, and functional retinal electrophysiology. Read More

Adv Ther 2021 06 21;38(6):3362-3372. Epub 2021 May 21.

Beijing Tongren Eye Center, Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.

Introduction: The present study aimed to analyze the clinical features of ocular pathology in patients with acquired immunodeficiency syndrome (AIDS) combined with syphilis.

Methods: A total of 129 patients with AIDS and syphilis who first visited the Department of Ophthalmology in Beijing YouAn Hospital between 2012 and 2019 were included in the study. All patients underwent ophthalmologic examinations, such as best-corrected visual acuity (BCVA), slit lamp, intraocular pressure, dilated fundus examination, and color fundus photography as well as systemic examinations related to AIDS and syphilis. Read More

Retin Cases Brief Rep 2021 May 17. Epub 2021 May 17.

Department of Ophthalmology, Klinikum Chemnitz gGmbH, Flemmingstrasse 2, 09116 Chemnitz, Germany. Phone: +49 371 333 33230. Fax: +49 371 333 33223. Email: Department of Endocrinology and Diabetology, Klinikum Chemnitz gGmbH, Flemmingstrasse 2, 09116 Chemnitz, Germany. Phone: +49 371 333 33232 Fax: +49 371 333 33224. Email:

Purpose: To report ocular manifestations of aceruloplasminemia (aCP) in two adult Caucasian siblings.Methods: The ocular findings were investigated using multimodal imaging approach including color fundus photography, fluorescein angiography, autofluorescence imaging, spectral-domain optical coherence tomography.

Results: A 43-year-old woman and a 39-year-old man were diagnosed with aCP based on clinical symptoms, laboratory tests, liver biopsy and genetic examination of the ceruloplasmin gene confirming the homozygotic mutation G708S. Read More

Am J Ophthalmol Case Rep 2021 Jun 16;22:101090. Epub 2021 Apr 16.

Icahn School of Medicine at Mount Sinai and New York Eye and Ear Infirmary of Mount Sinai, Department of Ophthalmology, New York, NY, USA.

Purpose: Fundus albipunctatus is an inherited cause of congenital stationary night blindness. The objective of this report is to describe structural changes occurring in a macular phenotype of a novel RDH5 mutation producing fundus albipunctatus using high-resolution imaging. A 62-year-old male with longstanding night blindness underwent imaging and genetic evaluation. Read More

Indian J Ophthalmol 2021 May;69(5):1271-1274

Department of Vitreo-Retina, Regional Institute of Ophthalmology, Minto Ophthalmic Hospital, BMCRI, Bengaluru, Karnataka, India.

Purpose: The aim of this work was to study and document retinal changes in coronavirus disease-2019 (COVID-19) positive patients with nonsevere disease using a nonmydriatic handheld fundus camera.

Methods: A cross-sectional observational study was conducted on patients affected by COVID-19 who were admitted at our center. Our study included patients with no, mild, and moderate symptoms (nonsevere cases). Read More

Int Ophthalmol 2021 Apr 8. Epub 2021 Apr 8.

Medical Research Foundation, Shri Bhagwan Mahavir Vitreo-Retinal Services, Sankara Nethralaya, 18 College Road, Chennai, 600006, Tamilnadu, India.

Purpose: To characterize the imaging features in eyes with vitreoretinal lymphoma (VRL) using ultra-widefield fundus photography (UWF-FP), swept-source optical coherence tomography (SSOCT) and fundus autofluorescence (FAF) that are correlated to ongoing treatment with intravitreal Rituximab(IVR).

Methods: Retrospective observational imaging-based study of 15 treatment-naive eyes with VRL treated with IVR. All patients with primary VRL underwent vitreous biopsy using 23/25G microincision vitrectomy system for confirmation of diagnosis. Read More

Indian J Ophthalmol 2021 04;69(4):812-823

Srimati Kanuri Santhamma Center for Vitreo-Retina Diseases, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Recent decade has seen a shift in the causes of childhood blinding diseases from anterior segment to retinal disease in both developed and developing countries. The common retinal disorders are retinopathy of prematurity and vitreoretinal infections in neonates, congenital anomalies in infants, and vascular retinopathies including type 1 diabetes, tumors, and inherited retinal diseases in children (up to 12 years). Retinal imaging helps in diagnosis, management, follow up and prognostication in all these disorders. Read More

Semin Ophthalmol 2021 May 23;36(4):185-190. Epub 2021 Feb 23.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

: Ultra-widefield (UWF) imaging of the myopic eye. : Myopes, and particularly high and pathologic myopes, present a unique challenge in fundoscopic imaging. Critical pathology is often located in the anteriormost portion of the retina, variations in posterior segment contour are difficult to capture in two-dimensional images, and extremes in axial length make simply focusing imaging devices difficult. Read More

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Feb;38(2):170-173

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan 640041, China. cn.

Objective: To explore the genetic basis for a child with ocular anomaly, microcephaly, growth retardation and intrauterine growth restriction.

Methods: The patient underwent ophthalmologic examinations including anterior segment photography, fundus color photography, and fundus fluorescein angiography. The patient and her parents were subjected to whole exome sequencing. Read More

Open Med (Wars) 2021 19;16(1):156-160. Epub 2021 Jan 19.

Department of Pediatric Ophthalmology, Children's Memorial Health Institute, Warsaw, Poland.

Background: Cohen syndrome (Q87.8;ORPHA:193; OMIM#216550) is an autosomal recessive inherited genetic disorder caused by mutation in the gene. It is characterized by variable clinical symptoms such as deformity of the head, face, hands and feet, eye abnormalities, abdominal obesity, neutropenia and nonprogressive intellectual disability. Read More

Eur J Ophthalmol 2020 Dec 14:1120672120977824. Epub 2020 Dec 14.

Department of Ophthalmology, Acibadem Hospital, Kayseri, Turkey.

Background: Optic nerve cells can be irreversibly damaged by common various causes. Unfortunately optic nerve and retinal ganglion cells have no regenerative capacity and undergo apoptosis in case of damage. In this study, our aim is to investigate the safety and efficacy of suprachoroidal umbilical cord-derived MSCs (UC-MSCs) implantation in patients with optic atrophy. Read More

Int J Stem Cells 2021 Feb;14(1):47-57

Ophthalmology Department, Kayseri Acibadem Hospital, Kayseri, Turkey.

Background And Objectives: This study shows the clinical data of 1-year follow-up of 8 patients with degenerative macular diseases who received suprachoroidal adipose tissue derived mesenchymal stem cell (ADMSC) implantation.

Methods And Results: This prospective, single-center, phase 1/2 study enrolled 8 eyes of 8 patients with degenerative macular diseases of various reasons who underwent suprachoroidal implantation of ADMSCs. All patients had severe visual field defects and severe visual loss. Read More

Am J Ophthalmol Case Rep 2020 Dec 18;20:100916. Epub 2020 Sep 18.

Doheny Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.

Purpose: This prospective case series investigates the visual and anatomical outcomes including detailed volumetrics of eyes with vascularized pigment epithelial detachments (PED) treated with aflibercept in eyes with neovascular age-related macular degeneration (nAMD) through meticulous analysis in a reading center setting.

Methods: We conducted a single-arm multicenter, prospective, open-labeled, interventional case series, comparing visual and anatomic outcomes at 12 months with baseline for intense aflibercept therapy. Eyes with submacular vascularized PED due to AMD received 2. Read More

Int J Ophthalmol 2020 18;13(9):1423-1429. Epub 2020 Sep 18.

Department of Ophthalmology, Kayseri Acibadem Hospital, Kayseri 38030, Turkey.

Aim: To investigate the efficacy and the safety of umbilical cord derived mesenchymal stem cell (UC-MSC) implantation in patients with retinitis pigmentosa (RP).

Methods: This prospective, single-center, phase 3 clinical study enrolled 124 eyes of 82 RP patients. The patients received 5 million UC-MSCs to the suprachoroidal area with a surgical procedure. Read More

Ophthalmic Genet 2021 02 17;42(1):71-74. Epub 2020 Sep 17.

Medical Genetics Division, Hospital de Clínicas de Porto Alegre (HCPA) , Porto Alegre, Brazil.

Background: Classic homocystinuria (HCU), or cystathionine beta-synthase (CBS) deficiency, is a rare inborn error of methionine metabolism. Main clinical features may include skeletal and vascular manifestations, developmental delay, intellectual disability and eye disorders.

Material And Methods: This is an observational and retrospective study aiming at describing eye abnormalities presented by a cohort of late-diagnosed HCU patients. Read More

Acta Diabetol 2020 Dec 4;57(12):1493-1499. Epub 2020 Aug 4.

Programa de Graduaçao em Medicina, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235, Sao Paulo, 01504-001, Brazil.

Aims: To evaluate diabetic retinopathy (DR) screening with a portable handheld smartphone-based retinal camera and telemedicine in an urban primary healthcare setting and to evaluate the learning curve for image acquisition, performed by healthcare personnel without previous experience in retinal imaging.

Methods: This was a prospective study that enrolled patients with type 2 diabetes mellitus (T2DM) followed at a primary healthcare unit in São Paulo, Brazil. After a brief training in image acquisition, there was further continuous feedback given by a retina specialist during the remote image reading process. Read More

Transl Vis Sci Technol 2020 02 27;9(3):30. Epub 2020 Feb 27.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California -Davis, Davis, CA, USA.

Purpose: To evaluate the safety and tolerability of a microsphere thermo-responsive hydrogel drug delivery system (DDS) loaded with aflibercept in a nonhuman primate model.

Methods: A sterile 50 µL of aflibercept-loaded microsphere thermo-responsive hydrogel-DDS (aflibercept-DDS) was injected intravitreally into the right eye of 10 healthy rhesus macaques. A complete ophthalmic examination, intraocular pressure (IOP) measurement, fundus photography, spectral-domain optical coherence tomography (SD-OCT), and electroretinogram were performed monthly for 6 months. Read More

Asia Pac J Ophthalmol (Phila) 2020 Jul-Aug;9(4):315-325

New York University (NYU Robert Grossman) School of Medicine, NYU Langone Health, New York, NY.

Purpose: The aim of this study was to assess the benefit and feasibility of the teleophthalmology GlobeChek kiosk in a community-based program.

Design: Single-site, nonrandomized, cross-sectional, teleophthalmologic study.

Methods: Participants underwent comprehensive evaluation that consists of a questionnaire form, brief systemic evaluation, screening visual field (VF), and GlobeChek kiosk screening, which included but not limited to intraocular pressure, pachymetry, anterior segment optical coherence tomography, posterior segment optical coherence tomography, and nonmydriatic fundus photography. Read More

Rom J Ophthalmol 2020 Apr-Jun;64(2):116-121

Discipline of Ophthalmology, "Grigore T. Popa" University of Medicine and Pharmacy, Iași, Romania; "Sf. Spiridon" Hospital, Iaşi, Romania.

This study aimed to determine the most frequent clinical aspects in patients with odontogenic orbital inflammation, the computed tomography (CT) aspect, and the most appropriate treatment. This is a retrospective case-series study conducted on 3 patients with ages between 16 and 55 years old, in the Ophthalmology and Oro-Maxillo-Facial Clinics of "Sf. Spiridon" Emergency Hospital, Iași, Romania. Read More

Eye (Lond) 2021 May 18;35(5):1398-1404. Epub 2020 Jun 18.

Núcleo de Telessaúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objectives: This study evaluates the quality of ophthalmic images acquired by a nurse technician trained in teleophthalmology as compared with images acquired by an ophthalmologist, in order to provide a better understanding of the workforce necessary to operate remote care programs.

Methods: A cross-sectional study was performed on 2044 images obtained from 118 participants of the TeleOftalmo project, in Brazil. Fundus and slit-lamp photography were performed on site by an ophthalmologist and by a nurse technician under the supervision of a remote ophthalmologist. Read More

BMC Ophthalmol 2020 Jun 8;20(1):221. Epub 2020 Jun 8.

Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Nihon University Hospital, 1-6 Kandasurugadai, Chiyoda-ku, Tokyo, 101-8309, Japan.

Background: Immune checkpoint inhibitors have recently been widely used for advanced cancers and are known to cause ocular complications. We herein report a case developing bilateral serous retinal detachments, without ocular inflammation, after starting nivolumab treatment.

Case Presentation: A 73-year-old man was referred to our hospital, having become aware of metamorphopsia 2 months after starting nivolumab (anti-programmed cell death protein 1 monoclonal antibody) for malignant melanoma of the nasal cavity. Read More

Lung Cancer 2020 07 28;145:167-172. Epub 2020 Apr 28.

Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA, USA.

Objectives: During crizotinib clinical evaluation, visual disturbances, generally of grade 1 severity, were frequently reported adverse events (AE). Consequently, ophthalmologic assessments were included in a patient subgroup enrolled in PROFILE 1001 (NCT00585195), a phase 1, open-label, single-arm trial of crizotinib in patients with advanced non-small-cell lung cancer and are reported here.

Materials And Methods: At least 30 patients were required to undergo ophthalmologic assessments, including: best-corrected visual acuity (BCVA), refractive error, pupil size, slit-lamp anterior segment biomicroscopy, intraocular inflammation, intraocular pressure, retinal fundoscopic exams, fundus photography, ocular characteristics, and optical coherence tomography (OCT). Read More

Am J Ophthalmol Case Rep 2020 Jun 7;18:100691. Epub 2020 Apr 7.

Bascom Palmer Eye Institute And, University of Miami Miller School of Medicine 900 NW 17th Street, Miami, FL, 33136, USA.

Purpose: To report a case of bilateral uveitis secondary to intravenous nivolumab therapy in a patient with stage IV non-small cell lung cancer.

Observations: A 53-year-old male with stage IV non-small cell lung cancer presented with gradual onset of blurry vision in the left eye for nine days after completion of the first cycle of intravenous nivolumab chemotherapy. At initial presentation, best-corrected visual acuity was 20/25 in the right eye and 20/30 in the left eye. Read More

Case Rep Ophthalmol Med 2020 10;2020:8398054. Epub 2020 Mar 10.

Department of Ophtalmology, Antalya Education and Research Hospital, Antalya, Turkey.

Purpose: The purpose of this case report is to present the findings of optical coherence tomography angiography (OCTA) of a patient with bilateral choroidal neovascularization (CNV) associated with optic disc drusen (ODD), who was treated with intravitreal aflibercept injection. A 14-year-old girl presented with a complaint of visual loss and metamorphopsia in her both eyes. Best-corrected visual acuity (BCVA) was 20/32 and 20/25, respectively, in the right and left eyes. Read More

Am J Ophthalmol Case Rep 2020 Jun 15;18:100618. Epub 2020 Feb 15.

Francis I. Proctor Foundation, 95 Kirkham St, University of California, San Francisco, CA, 94143, USA.

Purpose: This is a retrospective case report illustrating the diagnostic and therapeutic challenges associated with a chronic rhegmatogenous retinal detachment masquerading as a severe panuveitis with intense anterior chamber inflammation. We have included clinical features, anterior segment and fundus photography, B-scan ultrasonography, fluorescein angiography, and intraoperative findings.

Observations: A 26-year-old male presented with features of unilateral panuveitis: hypotony, anterior segment inflammation (posterior synechiae and anterior chamber cell with fibrin clumping), diffuse choroidal thickening, and retinal detachment. Read More

Asia Pac J Ophthalmol (Phila) 2020 Jan-Feb;9(1):54-58

Tilganga Institute of Ophthalmology, Kathmandu, Nepal.

Purpose: To determine whether use of a mobile device-based ophthalmic camera by ophthalmic technicians (OTs) in village screening camps in Nepal followed by remote image interpretation by an ophthalmologist can improve detection of ocular pathology and medical decision-making.

Design: Evaluation of mobile device-based ophthalmic camera through study of before and after clinical decision-making.

Methods: One hundred forty patients over 18 years of age presenting to remote screening camps with best-corrected visual acuity ≤20/60 in one or both eyes were enrolled. Read More

Eye Vis (Lond) 2020 19;7. Epub 2020 Jan 19.

2School of Ophthalmology and Optometry, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou, 325027 Zhejiang China.

Background: China is undergoing a massive transition toward an urban and industrial economy. These changes will restructure the demographics and economy which will eventually influence the future patterns of disease. The risk factors of vision-impairing eye diseases remain ambiguous and poorly understood. Read More

Open Respir Med J 2019 31;13:19-30. Epub 2019 Jul 31.

Somnlogist, Sleep Research Unit, Department of Psychiatry, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: This study sought to identify the magnitude and the possible risk factors of ocular complications in patients with Obstructive Sleep Apnea (OSA).

Methods: A hospital-based cross-sectional study with a nested case-control design was conducted. Qualifying study subjects were patients who had been diagnosed with moderate to severe OSA (AHI index of ≥ 5, n=80), and control subjects (n=20) who had an AHI index of ≤ 5 ("normal"). Read More

Curr Eye Res 2020 06 12;45(6):742-748. Epub 2019 Dec 12.

Department of Orthopedics, Jingzhou First People's Hospital, The First Affiliated Hospital of Yangtze University, Jingzhou, China.

: This study aims to evaluate the risk factors of retinal re-detachment and visual outcome after silicone oil removal (SOR) in silicone oil-filled eyes.: A total of 57 patients who underwent pars plana vitrectomy (PPV) and silicone oil injection for retinal detachment (RD), and subsequently underwent a silicone oil removal procedure. Pre-operative examinations were performed to determine the best-corrected visual acuity (BCVA) using the Snellen chart, while Icare was used to determine the intraocular pressure (IOP). Read More

World J Clin Cases 2019 Aug;7(16):2341-2345

Department of Ophthalmology, Tenth People's Hospital of Shanghai Affiliated to Tongji University, Shanghai 200072, China.

Background: Due to some similarities in the manifestations between central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV), PCV may be misdiagnosed as CSC. More attention should be paid to distinguishing these two disorders.

Case Summary: A 52-year-old woman presented to our hospital with blurred vision in her left eye for approximately 1 wk. Read More