The role of estrogen receptor subtypes for induction of delayed effects on the estrous cycle and female reproductive organs in rats.
- Miwa Takahashi,
- Ryohei Ichimura,
- Kaoru Inoue,
- Tomomi Morikawa,
- Kazunori Kuwata,
- Gen Watanabe,
- Midori Yoshida
Reprod Biol 2017 Feb 16. Epub 2017 Feb 16.
Food Safety Commission, Akasaka Park Bld. 22nd F. Akasaka 5-2-20, Minato-ku, Tokyo 107-6122, Japan. Electronic address:
It has been reported that neonatal exposure to estrogens at relatively low doses can induce early onset anovulation as a delayed effect in female rats. Dysfunction of kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) was proposed to be a trigger for this effect. To determine the roles of estrogen receptor (ER) subtypes in the induction of delayed effects, we conducted a series of experiments using Donryu rats to examine whether neonatal injection of an ERα agonist (PPT), an ERβ agonist (DPN) or an ERα antagonist (ICI) could induce delayed effects. Read More