459 results match your criteria Anoscopy


Comparison between anal cytology, high-resolution anoscopy and HPV DNA genotyping by polymerase chain reaction in the post-treatment follow-up of condylomata acuminata.

Rev Col Bras Cir 2020 3;47:e20202543. Epub 2020 Jul 3.

Instituto de Infectologia Emilio Ribas, São Paulo, SP, Brasil.

Aim: to evaluate the presence of subclinical HPV-induced anal lesions with anal cytology, High-Resolution Anoscopy (HRA) and HPV genotyping by polymerase chain reaction (PCR) in the follow-up of treated condylomata acuminata (CA).

Methods: seventy-nine male patients were included. One month after anal CA eradication, the patients underwent brush samples collection for anal cytology and PCR, and HRA with biopsy of acetowhite lesions. Read More

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http://dx.doi.org/10.1590/0100-6991e-20202543DOI Listing

Do we really need guidelines for HRA during COVID-19 pandemic? - Response.

Colorectal Dis 2020 Jun 21. Epub 2020 Jun 21.

Anal Neoplasia Clinic, Research and Education (ANCRE) Centre, University of California San Francisco, CA, 94115, USA.

Mistrangelo et al raise a number of issues in connection with the International Anal Neoplasia Society guidelines for the practice of High Resolution Anoscopy (HRA) in the era of COVID-19. The authors suggest that the guidelines advocate "mandatory" HRA for "screening". On the contrary, the guidelines clearly define risk prioritisation, in terms of both potential COVID-19 exposure and the dangers associated with delayed diagnosis of anal cancers. Read More

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http://dx.doi.org/10.1111/codi.15203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323216PMC

Risk of anal high-grade squamous intraepithelial lesions among renal transplant recipients compared with immunocompetent controls.

Clin Infect Dis 2020 Jun 16. Epub 2020 Jun 16.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Background: Renal transplant recipients (RTRs) have increased risk of human papillomavirus (HPV)-related cancers, including anal cancer. We investigated the prevalence of anal high-grade intraepithelial lesions (HSIL) in RTRs compared with immunocompetent controls and risk factors for anal HSIL in RTRs.

Methods: We included 247 RTRs and 248 controls in this cross-sectional study. Read More

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http://dx.doi.org/10.1093/cid/ciaa781DOI Listing

Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria.

Papillomavirus Res 2020 May 31;10:100200. Epub 2020 May 31.

University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Anal precancers and cancers can be detected during screening with high-resolution anoscopy (HRA). The sensitivity of HRA depends on the burden and duration of human papillomavirus (HPV) among those screened as well as anoscopist proficiency, which is highly correlated with prior screening experience. Our objective was to compare the identification and type of HPV and the likelihood of HRA-detected precancer for men who have sex with men (MSM) undergoing their first HRA-screening in Nigeria. Read More

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http://dx.doi.org/10.1016/j.pvr.2020.100200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287273PMC

Squamous cell anal cancer: Management and therapeutic options.

Ann Med Surg (Lond) 2020 Jul 12;55:36-46. Epub 2020 May 12.

Department of Surgery, Department of Applied Clinical Science and Biotechnology, University of L'Aquila, L'Aquila, Italy.

The incidence of anal cancer has increased during the second half of the 20th century, with an incidence rate over 2.9% greater than in the decade of 1992-2001. Yet, it still constitutes a small percentage, about 4%, of all anorectal tumours. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240186PMC

Mucopexy-Recto Anal Lifting (MuRAL) in managing obstructed defecation syndrome associated with prolapsed hemorrhoids and rectocele: preliminary results.

Ann Surg Treat Res 2020 May 28;98(5):277-282. Epub 2020 Apr 28.

Day/Week Surgery Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Purpose: Treatment of rectocele associated with prolapsed hemorrhoids is a debated topic. Transanal stapling achieved good midterm results in patients with symptoms of obstructed defecation, nevertheless a number of severe complications have been reported. The aim of this study was to evaluate the safety and efficacy of a new endorectal manual technique in patients with obstructed defecation due to the combination of muco-hemorrhoidal prolapse and rectocele. Read More

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http://dx.doi.org/10.4174/astr.2020.98.5.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200604PMC

Negative Predictive Value of Human Papillomavirus Testing: Implications for Anal Cancer Screening in People Living with HIV/AIDS.

J Oncol 2020 22;2020:6352315. Epub 2020 Jan 22.

Department of Obstetrics and Gynecology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, Henan 450003, China.

Objectives: People living with HIV/AIDS (PLWHA) have an increased incidence of anal squamous cell carcinoma. Since high-risk human papillomavirus (hrHPV) is the primary cause, hrHPV DNA testing may play an important role in anal cancer screening. This study aims to determine the negative predictive value (NPV) of hrHPV testing in PLWHA as well as factors that may lead to false-negative results. Read More

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http://dx.doi.org/10.1155/2020/6352315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204264PMC
January 2020

The Natural History of Anal High-grade Squamous Intraepithelial Lesions in Gay and Bisexual Men.

Clin Infect Dis 2020 Apr 28. Epub 2020 Apr 28.

The Kirby Institute, University of New South Wales, New South Wales, Australia.

Background: Gay and bisexual men (GBM) are disproportionately affected by anal cancer. Prevention is hindered by incomplete understanding of the natural history of its precursor, anal high-grade squamous intraepithelial lesions (HSIL).

Methods: The Study of the Prevention of Anal Cancer, conducted between 2010 and 2018, enrolled human immunodeficiency virus (HIV)-positive and HIV-negative GBM aged ≥35 years. Read More

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http://dx.doi.org/10.1093/cid/ciaa166DOI Listing

Cervical, anal and oral HPV detection and HPV type concordance among women referred for colposcopy.

Infect Agent Cancer 2020 15;15:22. Epub 2020 Apr 15.

12nd Obstetrics & Gynaecology Department, Molecular & Morphological Clinical Cytopathology Laboratory, Hippokration General Hospital, Medical Faculty, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Infection with human papillomaviruses (HPVs) can cause benign and malignant tumours in the anogenital tract and the oropharynx both in men and women. The aim of the presented study was to investigate cervical, anal, and oral HPV-detection rates among women referred to colposcopy for abnormal Cervical Cancer (CaCx) screening results and assess the concordance of HPV-types among these anatomical sites.

Methods: Women referred to colposcopy at a single centre due to abnormal cytology, conducted for CaCx screening, were subjected to cervical Liquid-based Cytology (LBC) smear testing, anal and oral sampling. Read More

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http://dx.doi.org/10.1186/s13027-020-00287-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160926PMC

Fundamentals of Anorectal Technical Skills: A Concise Surgical Skills Course.

Mil Med 2020 Apr 21. Epub 2020 Apr 21.

Division of General Surgery, Department of Surgery, Uniformed Services University of the Health Sciences (USUHS)/Walter Reed National Military Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20889.

Introduction: Anorectal diseases, among the most common surgical conditions, are underrepresented in medical training. The Fundamentals of Anorectal Technical Skills course was developed to provide cost-effective formal training in diagnosis of common anorectal conditions and in commonly performed anorectal procedures using the theories of deliberative practice and perceptual and adaptive learning.

Materials And Methods: First- through third-year general surgery and internal medicine residents and third- and fourth-year medical students participated in a course consisting of didactic instruction and hands on skills stations. Read More

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http://dx.doi.org/10.1093/milmed/usaa070DOI Listing

Acceptability of anal cancer screening tests for women living with HIV in the EVVA study.

Curr Oncol 2020 Feb 1;27(1):19-26. Epub 2020 Feb 1.

Department of Family Medicine, McGill University, Montreal, QC.

Background: Anal cancer is potentially preventable through screening. For screening to be implemented, the screening procedures must be acceptable to the affected population. The objective of the present study was to measure the acceptability of currently available anal cancer screening tests in a population of women living with hiv who had experienced the tests. Read More

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http://dx.doi.org/10.3747/co.27.5401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096206PMC
February 2020

Classifications and Clinical Assessment of Haemorrhoids:The Proctologist's Corner.

Rev Recent Clin Trials 2020 03 12. Epub 2020 Mar 12.

Department of Emergency and Organ Transplantation, University “Aldo Moro” of Bari, Bari, Italy

Background: Haemorrhoidal disease (HD) is a benign condition affecting a considerable part of adult population. HD can be considered a social and economic burden with high impact on patient lifestyle. Several new techniques and devices have been proposed for HD treatment; however, preoperative assessment is essential and the use of classification system is recommended. Read More

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http://dx.doi.org/10.2174/1574887115666200312163940DOI Listing

Racial Disparities in Anal Cancer Screening Among Men Living With HIV: Findings From a Clinical Cohort Study.

J Acquir Immune Defic Syndr 2020 Jul;84(3):295-303

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Background: Our objective was to quantify the extent of anal cancer screening among men receiving HIV specialty care in Ontario, Canada, and evaluate factors associated with screening.

Setting: Cross-sectional questionnaire within a multisite clinical HIV cohort.

Methods: A questionnaire assessing knowledge and experience with human papillomavirus-associated diseases and their prevention was administered in 2016-2017 to 1677 men in the Ontario HIV Treatment Network Cohort Study. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002335DOI Listing
July 2020
4.556 Impact Factor

Selective intra-arterial embolization to treat hemorrhoids.

Radiologia 2020 Jul - Aug;62(4):313-319. Epub 2020 Feb 3.

Servicio de Radiología, Sección de Radiología Vascular Intervencionista, Hospital Universitario de la Ribera, Alzira, Valencia, España.

Objective: To present our results and describe the technique used for the endovascular treatment of hemorrhoids.

Material And Methods: We used right femoral artery or radial artery access to catheterize the inferior mesenteric artery, proceeding to the superior rectal artery with a 2.7F microcatheter to catheterize and embolize each distal branch distally with PVA particles (300-500μm) and proximally with coils (2-3mm). Read More

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http://dx.doi.org/10.1016/j.rx.2019.12.004DOI Listing
February 2020

Satisfaction with high-resolution anoscopy for anal cancer screening among men who have sex with men: a cross-sectional survey in Abuja, Nigeria.

BMC Cancer 2020 Feb 5;20(1):98. Epub 2020 Feb 5.

University of Maryland Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Men who have sex with men (MSM) living with HIV are at increased risk for anal cancer. We evaluated satisfaction with first-time anal cancer screening using high resolution anoscopy (HRA) as a cross sectional survey among men who have sex with men (MSM) attending a community-engaged clinic in Abuja, Nigeria.

Methods: Between March and August 2017, 342 MSM underwent screening and 307 (89%) completed a satisfaction survey that evaluated 8 domains related to expectations, convenience, staff interpersonal skills, physical surroundings, technical competence, pain/discomfort, general satisfaction, and intention to re-screen if symptomatic. Read More

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http://dx.doi.org/10.1186/s12885-020-6567-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003335PMC
February 2020
3.362 Impact Factor

Brief Report: Recurrence of Anal High-Grade Squamous Intraepithelial Lesions Among Women Living With HIV.

J Acquir Immune Defic Syndr 2020 May;84(1):66-69

Department of Management Policy and Community Health, The University of Texas Health Science Center at Houston, School of Public Health, Houston, TX.

Background: Women living with HIV (WLHIV) have a high risk of developing invasive anal cancer. Anal cancer may be prevented with early detection and treatment of anal histologic high-grade squamous intraepithelial lesions (HSIL). However, there are limited data on the efficacy of anal HSIL treatment in WLHIV. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138737PMC
May 2020
4.556 Impact Factor

Electrocautery ablation of anal high-grade squamous intraepithelial lesions: Effectiveness and key factors associated with outcomes.

Cancer 2020 Apr 24;126(7):1470-1479. Epub 2020 Jan 24.

Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Electrocautery ablation (EA) is a common treatment modality for patients with anal high-grade squamous intraepithelial lesions (HSILs), but to the authors' knowledge its effectiveness has been understudied. The objective of the current study was to determine ablation outcomes and to identify clinicopathological factors associated with postablation disease recurrence.

Methods: A total of 330 people living with HIV with de novo intra-anal HSIL who were treated with EA from 2009 to 2016 were studied retrospectively. Read More

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http://dx.doi.org/10.1002/cncr.32581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069772PMC
April 2020
4.889 Impact Factor

Rectal cancer with extensive distal intramural spread treated by abdominoperineal resection.

Int Cancer Conf J 2020 Jan 7;9(1):9-13. Epub 2019 Aug 7.

1Department of Surgery, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, 470-1192 Aichi Japan.

Distal intramural spread refers to microscopic tumor implantation in the intestinal wall, distal to the inferior edge of a macroscopic tumor but rarely beyond 2 cm. We report a case of rectal cancer with preoperatively diagnosed distant intramural spread to approximately 6.5 cm. Read More

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http://dx.doi.org/10.1007/s13691-019-00385-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942609PMC
January 2020

Establishing an Anal Cancer Screening Program in an Outpatient HIV Clinic: Referral Patterns and Patient Perceptions Survey.

J Int Assoc Provid AIDS Care 2020 Jan-Dec;19:2325958219899530

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

People living with HIV are at high risk for anal cancer (AC); however, the impact of screening for and treatment of precancerous anal lesions on AC incidence remains uncertain. In 2013, we conducted a survey of HIV providers evaluating the perceived need for an institutional AC screening program. Based on an overwhelmingly positive response, we established a dedicated AC screening clinic (including provision of high-resolution anoscopies) embedded within the institutional HIV clinic. Read More

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http://dx.doi.org/10.1177/2325958219899530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961137PMC
January 2020

Prevalence and associations of larger burden of intra-anal high-grade squamous intraepithelial lesions at baseline in an Australian cohort of gay and bisexual men: The Study of the Prevention of Anal Cancer.

Cancer Epidemiol 2020 Feb 7;64:101661. Epub 2020 Jan 7.

The Kirby Institute, Wallace Wurth Building, UNSW Sydney, Randwick, New South Wales 2031, Australia. Electronic address:

Objectives: To investigate factors associated with larger burden of intra-anal high-grade squamous intraepithelial lesions (HSIL) in a natural history study of HSIL.

Methods: 617 gay and bisexual men (GBM) attended a baseline visit. High-resolution anoscopy-directed biopsy was performed of suspected HSIL. Read More

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http://dx.doi.org/10.1016/j.canep.2019.101661DOI Listing
February 2020

Anal dysplasia and HIV shedding in ART-treated men.

Sex Transm Infect 2020 Jan 6. Epub 2020 Jan 6.

Department of Immunology, University of Toronto, Toronto, Ontario, Canada.

Objectives: Anal human papillomavirus (HPV) infection is highly prevalent among men who have sex with men (MSM). HPV-associated anal dysplasia has been linked with anal HIV RNA shedding despite antiretroviral therapy (ART). Since mucosal HIV levels are a key determinant of sexual transmission of the virus, this would have important public health implications. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054262DOI Listing
January 2020
3.401 Impact Factor

Benign Anorectal Conditions: Evaluation and Management.

Am Fam Physician 2020 01;101(1):24-33

University of Virginia School of Medicine, Charlottesville, VA, USA.

Common anorectal conditions include hemorrhoids, perianal pruritus, anal fissures, functional rectal pain, perianal abscess, condyloma, rectal prolapse, and fecal incontinence. Although these are benign conditions, symptoms can be similar to those of cancer, so malignancy should be considered in the differential diagnosis. History and examination, including anoscopy, are usually sufficient for diagnosing these conditions, although additional testing is needed in some situations. Read More

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January 2020

Early Detection of Anal High-Grade Squamous Intraepithelial Lesion: Do We Have an Impact on Progression to Invasive Anal Carcinoma?

J Low Genit Tract Dis 2020 Jan;24(1):82-86

From the Department of Proctology, Diaconesses-Croix Saint-Simon Hospital, Paris, France.

Objective: Anal high-grade squamous intraepithelial lesion (HSIL) may precede invasive cancer and can be detected clinically or during high-resolution anoscopy (HRA). The aims of this study were to compare the characteristics of HSIL discovered by HRA or in a surgical specimen without clinically visible lesion when diagnosed versus macroscopic HSIL when first diagnosed and then to compare their progression to invasive cancer.

Patients And Methods: Clinical records of all patients with at least one HSIL lesion confirmed by histology and evaluated by HRA in a single center between September 1, 2009, and April 30, 2017, were retrospectively reviewed. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000505DOI Listing
January 2020

Assessment of Anal Cancer Screening Tools in Detecting High-Grade Anal Squamous Intraepithelial Lesions in Women.

J Low Genit Tract Dis 2020 Jan;24(1):75-81

Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.

Objective: The aim of the study was to evaluate the validity of anal cytology against high-resolution anoscopy in the detection of anal high-grade squamous intraepithelial lesions (HSILs) among women in a clinical setting in Puerto Rico, alone and in combination with high-risk human papillomavirus (HR-HPV) typing.

Materials And Methods: A cross-sectional study was done among 128 eligible women who attended the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Center between 2014 and 2019. Kappa (κ) coefficient, sensitivity, specificity, positive predictive value, and negative predictive value were calculated using high-resolution anoscopy with biopsy as the criterion standard test. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000497DOI Listing
January 2020

Recommendations Favoring Anal Cytology as a Method for Anal Cancer Screening: A Systematic Review.

Cancers (Basel) 2019 Dec 4;11(12). Epub 2019 Dec 4.

Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal.

Clinicians are increasingly facing the decision of performing anal cancer screening in high-risk groups. Anal cytology is commonly the first approach. We systematically reviewed recommendations favoring anal cytology for anal cancer screening. Read More

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http://dx.doi.org/10.3390/cancers11121942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966611PMC
December 2019

Anal Dysplasia in Human Immunodeficiency Virus-Infected Men Who Have Sex With Men With Sexually Acquired Early Hepatitis C Virus Infection.

Open Forum Infect Dis 2019 Nov 25;6(11):ofz339. Epub 2019 Nov 25.

Division of Infectious Diseases, Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) are at increased risk of anorectal infection with high-risk human papillomavirus and subsequent high-grade squamous intraepithelial lesions (HSIL), the putative precursor to anal cancer. Recently, an epidemic of sexually transmitted hepatitis C virus (HCV) has emerged that shares this anorectal route of transmission. We hypothesized that the prevalence of anal HSIL would be high in HIV-infected MSM with sexually acquired early HCV infection. Read More

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http://dx.doi.org/10.1093/ofid/ofz339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876538PMC
November 2019

Anal Squamous Intraepithelial Lesions (SILs) in Human Immunodeficiency Virus-Positive Men Who Have Sex With Men: Incidence and Risk Factors of SIL and of Progression and Clearance of Low-Grade SILs.

J Infect Dis 2020 Jun;222(1):62-73

Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.

Background: Human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) are at risk of anal squamous cell carcinoma. Data are limited on the natural history of the precursor to this carcinoma, anal squamous intraepithelial lesions (SILs).

Methods: HIV-positive MSM were screened for histopathological SILs by means of high-resolution anoscopy (HRA). Read More

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http://dx.doi.org/10.1093/infdis/jiz614DOI Listing

The Natural History of Anal Dysplasia: Unwrapping the Riddle to Find an Enigma.

Authors:
Luis F Barroso

J Infect Dis 2020 Jun;222(1):7-8

Internal Medicine/Infectious Diseases, Wake Forest Baptist Health, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1093/infdis/jiz616DOI Listing

Video anoscopy: results of routine anal examination during colonoscopies.

Endosc Int Open 2019 Nov 11;7(11):E1549-E1562. Epub 2019 Nov 11.

Department of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

 Anal examination and video anoscopy (VA) are rarely performed during colonoscopies. The aim of this study is to demonstrate that anal examination and VA provide important information in all routine colonoscopies.  A cross-sectional study was conducted on 12,151 patients screened by VA which were performed during routine outpatient colonoscopy between 2006 and 2018. Read More

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http://dx.doi.org/10.1055/a-0998-3958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847703PMC
November 2019
3 Reads

Diagnosing uncertainty: The challenges of implementing medical screening programs for minority sub-populations in Canada.

Soc Sci Med 2020 01 28;244:112643. Epub 2019 Oct 28.

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. Electronic address:

The social science literature on medical screening has documented a notable disjuncture between the promises of population-based screening programs and the complex realities of their rollout in everyday practice. We contribute to this scholarship by examining how healthcare providers confront numerous uncertainties associated with the implementation of anal cancer screening programs in Canada given the absence of standardized national evidence-based guidelines. The data was derived from in-depth interviews conducted with 13 physicians and 2 clinical researchers about anal cancer screening for gay, bisexual and other men who have sex with men living with HIV, the minority sub-population at the highest risk for HPV-associated anal cancer. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.112643DOI Listing
January 2020
2.890 Impact Factor

Anal fissure management by the gastroenterologist.

Curr Opin Gastroenterol 2020 Jan;36(1):19-24

Division of Gastroentrology, Dept of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Purpose Of Review: Anal fissures are very common. They are easy to diagnose and treat in the office setting. They may coexist with hemorrhoids. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000599DOI Listing
January 2020
1 Read

mRNA Detection in Anal Cytology: A Feasible Approach for Anal Cancer Screening in Men Who Have Sex with Men Living With HIV.

Diagnostics (Basel) 2019 11 2;9(4). Epub 2019 Nov 2.

Department of Pathology, Hospital Clínic, University of Barcelona, 08036 Barcelona, Spain.

There is growing interest in anal cancer screening strategies. However, cytological/molecular evaluation of anal samples is challenging. We aimed to determine the feasibility of detecting, in anal liquid-based cytologies, the expression of biomarkers involved in the cell cycle disturbance elicited by human papillomavirus (HPV). Read More

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http://dx.doi.org/10.3390/diagnostics9040173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963475PMC
November 2019

ART is key to clearing oncogenic HPV genotypes (HR-HPV) in anal mucosa of HIV-positive MSM.

PLoS One 2019 24;14(10):e0224183. Epub 2019 Oct 24.

Department of Infectious Diseases; "Virgen de las Nieves" University Hospital, Granada, Spain.

Background: Anal squamous cell carcinoma (ASCC) is one of the most frequent non-AIDS-defining neoplasias in HIV patients, mainly in MSM, and it has been associated with chronic infection with high-risk human papilloma virus (HR-HPV). Our main objective was to determine HR-HPV clearance and acquisition rates and related factors and their relationship with the incidence of HSILs and ASCC in anal mucosa of HIV+ MSM.

Patients And Methods: The study included consecutive HIV-infected MSM between May 2010 and December 2018. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224183PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813028PMC
March 2020
1 Read

Screening for Anal Cancer in Women With a History of Vulvar High-Grade Squamous Intraepithelial Lesions.

J Low Genit Tract Dis 2019 Oct;23(4):265-271

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: The primary obkective was to determine the prevalence of (a) a positive anal cancer screen and (b) histological anal high-grade squamous intraepithelial lesion (HSIL) in women undergoing surveillance for previously diagnosed and treated human papillomavirus (HPV)-associated vulvar HSIL. The secondary objective was to determine the patients' acceptability of the screen.

Materials And Methods: This is a single-institution, cross-sectional pilot study. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000490DOI Listing
October 2019
1 Read

Psychological and utility-based quality of life impact of screening test results for anal precancerous lesions in gay and bisexual men: baseline findings from the Study of the Prevention of Anal Cancer.

Sex Transm Infect 2020 05 1;96(3):177-183. Epub 2019 Aug 1.

Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia

Objective: Gay, bisexual and other men who have sex with men (GBMSM), particularly HIV-positive GBMSM, are at increased anal cancer risk compared with the general population. This study examined the psychological and quality of life (QoL) impact of receiving abnormal anal cancer screening results during the baseline visit of the Study of the Prevention of Anal Cancer (SPANC).

Methods: SPANC was a prospective cohort study of the natural history of anal human papillomavirus (HPV) and associated abnormalities in GBM aged 35 years and over. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054098DOI Listing
May 2020
4 Reads

Clinical results of infrared coagulation as a treatment of high-grade anal dysplasia: a systematic review.

Tech Coloproctol 2019 Aug 23;23(8):707-712. Epub 2019 Jul 23.

Lluita Contra la Sida Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.

Background: Anal intraepithelial neoplasia (AIN) (or low/high grade squamous intraepithelial neoplasia (L/HSIL)) is the precursor of anal of early invasive anal cancer. Different treatment options for local ablation of localized lesions have been reported. The aim of this study was to analyze the clinical efficacy and safety of infrared coagulation for the treatment of anal dysplasia. Read More

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http://dx.doi.org/10.1007/s10151-019-02041-7DOI Listing
August 2019
2 Reads

Implementation of and Early Outcomes From Anal Cancer Screening at a Community-Engaged Health Care Facility Providing Care to Nigerian Men Who Have Sex With Men.

J Glob Oncol 2019 07;5:1-11

University of Maryland School of Medicine, Baltimore, MD.

Purpose: Anal cancer risk is substantially higher among HIV-infected men who have sex with men (MSM) as compared with other reproductive-age adults, but screening is rare across sub-Saharan Africa. We report the use of high-resolution anoscopy (HRA) as a first-line screening tool and the resulting early outcomes among MSM in Abuja, Nigeria.

Methods: From August 2016 to August 2017, 424 MSM enrolled in an anal cancer screening substudy of TRUST/RV368, a combined HIV prevention and treatment cohort. Read More

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http://dx.doi.org/10.1200/JGO.19.00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690628PMC
July 2019
8 Reads

Femoral Head Dislocation into the Rectum Following Blunt Trauma.

Cureus 2019 May 3;11(5):e4596. Epub 2019 May 3.

Surgery, University of Texas Health Science Center at San Antonio, San Antonio, USA.

Traumatic hip dislocations require prompt diagnosis and treatment to prevent avascular necrosis of the femoral head. This injury is further complicated when there is an ipsilateral femur fracture. Here, we present what is likely the first reported case of a patient with traumatic hip dislocation and ipsilateral femur fracture with transrectal displacement of the femoral head. Read More

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http://dx.doi.org/10.7759/cureus.4596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609309PMC
May 2019
4 Reads

Screening for anal cancer precursors among patients living with HIV in the absence of national guidelines: practitioners' perspectives.

Cancer Causes Control 2019 Sep 13;30(9):989-996. Epub 2019 Jul 13.

College of Health Solutions, Arizona State University, Phoenix, AZ, USA.

Purpose: Immunocompromised populations including people living with HIV (PLWH) suffer disproportionate burden from anal cancer, a rare cancer caused by persistent infection of the anal canal with oncogenic strains of human papillomavirus. In the US, there are no nationally adopted screening guidelines for anal cancer. In the absence of such guidelines, this study explores healthcare practitioners' screening practices for early signs of anal cancer among PLWH. Read More

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http://dx.doi.org/10.1007/s10552-019-01209-8DOI Listing
September 2019
1 Read
2.735 Impact Factor

Prevalence of and Risk Factors for Anal High-grade Squamous Intraepithelial Lesions in Women Living with Human Immunodeficiency Virus.

Clin Infect Dis 2020 Apr;70(8):1701-1707

Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine.

Background: Women living with human immunodeficiency virus (WLHIV) have disproportionately high rates of squamous cell carcinoma of the anus compared with the general population of women. Anal high-grade squamous intraepithelial lesions (HSILs) precede anal cancer, and accurate studies of HSIL prevalence among WLHIV in the United States are lacking.

Methods: The AIDS Malignancy Consortium 084 study was a multicenter national trial to evaluate the prevalence of and risk factors for anal HSIL in a US cohort. Read More

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http://dx.doi.org/10.1093/cid/ciz408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146000PMC
April 2020
5 Reads
8.886 Impact Factor

Anal Intraepithelial Neoplasia Screening With Anal Pap Tests: Follow-up and Corresponding Histology.

J Surg Res 2019 12 5;244:117-121. Epub 2019 Jul 5.

Division of Colon and Rectal Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; Department of Surgery, W. S. Middleton Memorial Veteran's Hospital, Madison, Wisconsin.

Background: Anal cytology is used as a screening tool in the detection of precancerous anal squamous lesions. Follow-up clinical examination after abnormal anal cytology is recommended. The objective of this study was to determine how often abnormal cytology was followed by a clinical examination at our institution and how often cytology predicted histologic outcome. Read More

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http://dx.doi.org/10.1016/j.jss.2019.06.029DOI Listing
December 2019
6 Reads

Infection With Chlamydia trachomatis Increases the Risk of High-grade Anal Intraepithelial Neoplasia in People Living With Human Immunodeficiency Virus.

Clin Infect Dis 2020 May;70(10):2161-2167

Infectious Diseases Unit, Hospital General de Elche & Universidad Miguel Hernández, Spain.

Background: We aimed to assess the relationship between sexually transmitted infections (STIs)-including a large panel of human papillomavirus (HPV) genotypes-and high-grade anal intraepithelial neoplasia (HGAIN) in men who have sex with men (MSM) who were living with human immunodeficiency virus (HIV).

Methods: In a prospective study in an HIV cohort, participants underwent high-resolution anoscopy (HRA) for anorectal swabs collection to investigate STIs and for anal biopsy. Multiplex real-time polymerase chain reactions were performed, detecting several STIs and 28 HPV genotypes. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz606DOI Listing
May 2020
12 Reads

The Role of High-resolution Anoscopy and Random Biopsies: The Role of Infrared Coagulation vs Active Monitoring in the Treatment of High-grade Squamous Intraepithelial Lesions.

Clin Infect Dis 2020 Feb;70(5):987

Surgical Science Department, University of Turin, Città della Salute e della Scienza di Torino.

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http://dx.doi.org/10.1093/cid/ciz487DOI Listing
February 2020
6 Reads
8.886 Impact Factor

Importance of anal cytology and screening for anal dysplasia in individuals living with HIV with an emphasis on women.

Cancer Cytopathol 2019 06 30;127(6):407-413. Epub 2019 May 30.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.

Background: The incidence of squamous cell carcinoma of the anal canal has been increasing in high-risk populations. To the authors' knowledge, there is no international consensus regarding screening for squamous cell carcinoma of the anal canal, but screening is commonly comprised of a Papanicolaou (Pap) test in combination with digital anorectal examination followed by high-resolution anoscopy if necessary. The current study focused on individuals living with HIV and particularly on women living with HIV. Read More

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http://dx.doi.org/10.1002/cncy.22151DOI Listing
June 2019
7 Reads

The Accuracy of Anal Swab-Based Tests to Detect High-Grade Anal Intraepithelial Neoplasia in HIV-Infected Patients: A Systematic Review and Meta-analysis.

Open Forum Infect Dis 2019 May 16;6(5):ofz191. Epub 2019 Apr 16.

Department of Dermatology, Amsterdam Institute for Infection and Immunity (AI&II), Amsterdam, the Netherlands.

Background: The incidence of high-risk human papillomavirus (HR-HPV)-induced anal cancer is increasingly problematic among HIV-positive patients. Anal cancer is preceded by precursor lesions, anal intraepithelial neoplasia (AIN). AIN detection requires high-resolution anoscopy, a cumbersome and time-consuming procedure. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz19
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http://dx.doi.org/10.1093/ofid/ofz191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524827PMC
May 2019
7 Reads

Progression of LSIL to HSIL or SCC: is anoscopy and biopsy good enough?

Tech Coloproctol 2019 04 18;23(4):303-304. Epub 2019 May 18.

Surgical Science Department, Città della Salute e della Scienza Hospital, Turin, Italy.

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http://link.springer.com/10.1007/s10151-019-02001-1
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http://dx.doi.org/10.1007/s10151-019-02001-1DOI Listing
April 2019
7 Reads

Pilot Study of Markers for High-grade Anal Dysplasia in a Southern Cohort From the Women's Interagency Human Immunodeficiency Virus Study.

Clin Infect Dis 2020 Mar;70(6):1121-1128

Atlanta Women's Interagency HIV Study, Rollins School of Public Health, Emory University, Georgia.

Background: Anal cancer rates have increased, particularly in human immunodeficiency virus (HIV)-infected (HIV+) women. We assessed factors associated with anal precancer in HIV+ and at-risk HIV-negative women from the Atlanta Women's Interagency HIV Study cohort.

Methods: All participants underwent high-resolution anoscopy and anal cytology and had anal and cervical samples collected. Read More

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http://dx.doi.org/10.1093/cid/ciz336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319055PMC
March 2020
18 Reads

Progression of anal intraepithelial neoplasia in HIV-positive individuals: predisposing factors.

Tech Coloproctol 2019 Apr 23;23(4):325-332. Epub 2019 Apr 23.

Department of General Surgery, Section of Colon and Rectal Surgery, Vanderbilt University Medical Center, 1161 21st Ave South, Room D5248 MCN, Nashville, TN, 37232, USA.

Background: The aim of the present study was to evaluate patient factors that affect the progression of anal dysplasia in human immunodeficiency virus (HIV)-positive individuals.

Methods: A retrospective cohort study of HIV-positive adults with human papilloma virus related anal lesions was performed from 2012 to 2017. All patients underwent surgical excision or biopsy and fulguration of lesions in the operating room without using high resolution anoscopy. Read More

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http://dx.doi.org/10.1007/s10151-019-01951-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582960PMC
April 2019
6 Reads

Early Outcomes of a High-Resolution Anoscopy-Based Anal Cancer Screening Program Among People With HIV Enrolled in an Integrated Health Care System.

J Acquir Immune Defic Syndr 2019 07;81(3):292-299

Division of Research, Kaiser Permanente Northern California, Oakland, CA.

Background: Few studies have examined outcomes of high-resolution anoscopy (HRA)-based screening for people with HIV infection (PWH), a population at increased risk for anal cancer.

Setting: Large integrated health care system.

Methods: Cohort study of 13,552 people with HIV infection, comparing incidences of anal cancer and advanced anal cancer (higher stage, recurrence, death, or surgical salvage) before and after HRA became available (2008). Read More

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http://dx.doi.org/10.1097/QAI.0000000000002040DOI Listing
July 2019
13 Reads

Comparison of nylon-flocked swab and Dacron swab cytology for anal HSIL detection in transgender women and gay, bisexual, and other men who have sex with men.

Cancer Cytopathol 2019 04 26;127(4):247-257. Epub 2019 Mar 26.

School of Nursing, University of California Los Angeles, Los Angeles, California.

Background: An anal histological high-grade squamous intraepithelial lesion (hHSIL) is an anal cancer precursor. Experts recommend Dacron swab anal cytology as a primary screen for anal hHSILs, especially among human immunodeficiency virus-infected and -uninfected men who have sex with men (MSM). Studies have shown that Dacron cytology inaccurately predicts anal hHSILs and results in unnecessary diagnostic procedures. Read More

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http://dx.doi.org/10.1002/cncy.22114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108036PMC
April 2019
13 Reads