410 results match your criteria Anoscopy


Progression of anal intraepithelial neoplasia in HIV-positive individuals: predisposing factors.

Tech Coloproctol 2019 Apr 23. Epub 2019 Apr 23.

Department of General Surgery, Section of Colon and Rectal Surgery, Vanderbilt University Medical Center, 1161 21st Ave South, Room D5248 MCN, Nashville, TN, 37232, USA.

Background: The aim of the present study was to evaluate patient factors that affect the progression of anal dysplasia in human immunodeficiency virus (HIV)-positive individuals.

Methods: A retrospective cohort study of HIV-positive adults with human papilloma virus related anal lesions was performed from 2012 to 2017. All patients underwent surgical excision or biopsy and fulguration of lesions in the operating room without using high resolution anoscopy. Read More

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http://dx.doi.org/10.1007/s10151-019-01951-wDOI Listing

Early outcomes of a high-resolution anoscopy-based anal cancer screening program among people with HIV enrolled in an integrated healthcare system.

J Acquir Immune Defic Syndr 2019 Mar 29. Epub 2019 Mar 29.

Kaiser Permanente Northern California, Division of Research.

Background: Few studies have examined outcomes of high-resolution anoscopy (HRA)-based screening for people with HIV infection (PWH), a population at increased risk for anal cancer. SETTING00:: Large integrated healthcare system.

Methods: Cohort study of 13,552 PWH, comparing incidences of anal cancer and advanced anal cancer (higher stage, recurrence, death or surgical salvage) before and after high-resolution anoscopy (HRA) became available (2008). Read More

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http://dx.doi.org/10.1097/QAI.0000000000002040DOI Listing
March 2019
1 Read

Comparison of nylon-flocked swab and Dacron swab cytology for anal HSIL detection in transgender women and gay, bisexual, and other men who have sex with men.

Cancer Cytopathol 2019 Apr 26;127(4):247-257. Epub 2019 Mar 26.

School of Nursing, University of California Los Angeles, Los Angeles, California.

Background: An anal histological high-grade squamous intraepithelial lesion (hHSIL) is an anal cancer precursor. Experts recommend Dacron swab anal cytology as a primary screen for anal hHSILs, especially among human immunodeficiency virus-infected and -uninfected men who have sex with men (MSM). Studies have shown that Dacron cytology inaccurately predicts anal hHSILs and results in unnecessary diagnostic procedures. Read More

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http://dx.doi.org/10.1002/cncy.22114DOI Listing
April 2019
1 Read

New Insights into the Role of Human Papillomavirus in Anal Cancer and Anal Wart Development.

Acta Cytol 2019 12;63(2):118-123. Epub 2019 Mar 12.

Faculty of Medicine of the University of Porto, Porto, Portugal,

Human papillomavirus is associated with several anogenital and oropharyngeal lesions, including warts, premalignant lesions, and cancer. There are specific groups that were identified as high-risk groups for anal squamous cell carcinoma and anal human papillomavirus infection, namely HIV-positive patients, men who have sex with men, women with genital tract neoplasia, and solid organ transplant recipients. Condylomas have classically been considered to be a benign lesion, with an exception made for the Buschke-Loewenstein tumor, but several publications have shown that a high percentage of condylomas harbor high-grade lesions. Read More

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http://dx.doi.org/10.1159/000491815DOI Listing
March 2019
6 Reads

Prevalence of high-grade anal dysplasia among women with high-grade lower genital tract dysplasia or cancer: Results of a pilot study.

Gynecol Oncol 2019 Feb 28. Epub 2019 Feb 28.

The Department of Gynecologic Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Objective: To estimate the prevalence of high-grade anal dysplasia in women with high-grade dysplasia or carcinoma of the cervix, vagina or vulva.

Methods: In this cross-sectional study, participants underwent anal cytology, anal HPV testing with Cervista HPV16/18 and high-resolution anoscopy (HRA). Patients with HSIL (high-grade squamous cell intraepithelial lesion) or greater on anal cytology or anal biopsy were referred to a colorectal surgery specialist for further evaluation. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.024DOI Listing
February 2019
2 Reads
3.774 Impact Factor

High-risk human papilloma virus testing improves diagnostic performance to predict moderate-to-high grade anal intraepithelial neoplasia in HIV-infected men who have sex with men in low-to-absent cytological abnormalities.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

Unidad Clínica de Enfermedades Infecciosas y Medicina Preventiva (UCEIMP). Hospital Universitario Virgen del Rocío. Seville, Spain.

Background: Screening methods for anal intraepithelial neoplasia (AIN) are suboptimal. This study aimed to determine the diagnostic performance of a composite endpoint comprising anal liquid-based cytology (aLBC) and high-risk human papillomavirus (HR-HPV) testing to predict histological high-grade squamous intraepithelial lesions (HSIL).

Methods: From a cohort of HIV-infected men who have sex with men (MSM) seen at a Spanish University hospital, all individuals who had an aLBC with concomitant HR-HPV testing were included. Read More

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http://dx.doi.org/10.1093/cid/ciz144DOI Listing
February 2019
1 Read

Feasibility of screening for anal cancer in HIV-positive people older than 50 years in Canada.

Authors:
Edward S Weiss

CMAJ 2019 Feb;191(6):E171

Family physician and high-resolution anoscopy practitioner, University Health Network, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.71187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370533PMC
February 2019
1 Read

Human papillomavirus DNA detection-guided ALA-photodynamic therapy for anogenital condyloma acuminata: A report of two cases.

Photodiagnosis Photodyn Ther 2019 Mar 6;25:460-462. Epub 2019 Feb 6.

Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

5-aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) is a highly effective, safe, and promising treatment for human papillomavirus (HPV)-induced anogenital condyloma acuminata (CA). Specific HPV subtypes are responsible for the pathogenesis of CA and dynamic changes in viral loads may reflect the efficiency of PDT. Here we present two cases of anogenital CA successfully treated by ALA-PDT under the guidance of HPV DNA detection including genotype identification and viral load measurement, which provided clues for unexpected intra-anal infection. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.02.003DOI Listing
March 2019
1 Read

High-resolution anoscopy in HIV-infected men: Assessment of the learning curve and factors that improve the performance.

Papillomavirus Res 2019 Feb 1;7:62-66. Epub 2019 Feb 1.

Unidad Clínica de Enfermedades Infecciosas y Medicina Preventiva (UCEIMP), Hospital Universitario Virgen del Rocío, Seville, Spain.

Objective: To determine the required learning time for high-resolution anoscopy (HRA)-guided biopsy to detect histological high-risk squamous intraepithelial lesions (hHSIL) and to identify factors that impact on the training process.

Methods: All HIV-infected, screening-naïve men-who-have-sex-with-men who underwent HRA conducted by one single observer from 2010 to 2017 in a Spanish HIV-outpatient clinic were analysed.

Results: Eighty-five (14. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058521183012
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http://dx.doi.org/10.1016/j.pvr.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374501PMC
February 2019
21 Reads

Raman-Enhanced Spectroscopy Distinguishes Anal Squamous Intraepithelial Lesions in Human Immunodeficiency Virus-Serodiscordant Couples.

AIDS Res Hum Retroviruses 2019 Mar 4;35(3):287-294. Epub 2019 Feb 4.

2 Department of Tropical Medicine, Medical Microbiology and Pharmacology, Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.

HIV-positive individuals are at increased risk for precancerous anal squamous intraepithelial lesions (SILs). Anal cytology and digital rectal examination are performed as screening tools, but extensive training and appropriate instruments are required to follow up on an abnormal anal cytology. Thus, novel approaches to SIL evaluation could improve better health care follow-up by efficient and timely diagnosis to offer treatment options. Read More

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http://dx.doi.org/10.1089/AID.2018.0198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434716PMC
March 2019
5 Reads

An Update on the Current Role of High Resolution Anoscopy in Patients With Anal Dysplasia.

Anticancer Res 2019 Jan;39(1):17-23

Division of Colorectal Surgery, Department of Surgery, Drexel University, Philadelphia, PA, U.S.A.

The incidence of anal squamous cell carcinoma (ASCC) in the U.S. is increasing, particularly in immunocompromised patients. Read More

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http://dx.doi.org/10.21873/anticanres.13075DOI Listing
January 2019
5 Reads

Squamous cell carcinoma of the anal canal.

Curr Probl Cancer 2018 09 23;42(5):486-492. Epub 2018 Nov 23.

Brigham and Women's Hospital, Boston, Massachusetts.

Anal squamous cell carcinoma (SCC) is a rare cancer and accounts for approximately 4% of all cancers of the lower alimentary tract. The dominant etiology is infection with human papilloma virus (HPV), which is the most common sexually transmitted disease in the United States. Integration of HPV DNA into the host genome seems to be the driving mechanism behind carcinogenesis. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2018.11.001DOI Listing
September 2018
5 Reads

Effect of an Educational Video to Increase Calls and Screening into an Anal Cancer Clinical Trial Among HIV+ Hispanics in PR: Results from a Randomized Controlled Behavioral Trial.

AIDS Behav 2018 Nov 22. Epub 2018 Nov 22.

Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.

Anal cancer incidence is higher in persons living with HIV/AIDS (PLWHA) than in the general population. Participation of PLWHA in anal cancer clinical trials (CTs) is essential; Hispanic PLWHA are underrepresented in CTs. We conducted a behavioral CT among 305 PLWHA in Puerto Rico to measure the efficacy of an educational video in increasing calls and screening into an anal cancer CT. Read More

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http://dx.doi.org/10.1007/s10461-018-2330-zDOI Listing
November 2018
13 Reads

History of High-Resolution Anoscopy.

Clin Colon Rectal Surg 2018 Nov 2;31(6):336-346. Epub 2018 Nov 2.

Department of General Surgery, University of Washington, Seattle, Washington.

High-resolution anoscopy (HRA) is a form of low-resolution anal microscopy currently utilized in the screening and management of anal squamous dysplasia. No randomized controlled trials, national or international guidelines exist on the use of HRA for this purpose. Much of our understanding of this entity has been adapted from the literature on cervical squamous dysplasia, including the technique of HRA itself. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1668103
Publisher Site
http://dx.doi.org/10.1055/s-0038-1668103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237179PMC
November 2018
17 Reads

Transanal repair of rectocele with high frequency radio scalpel.

G Chir 2018 Sep-Oct;34(5):303-308

Aim: This is a prospective randomized study to analyze results obtained in two groups of patients, affected by stage 2 rectocele and treated with rectum anterior wall repair and strength, performed with standard or modified Khubchandani technique, using High Frequency (HF) Radio Scalpel.

Materials And Methods: A cohort of 24 patients with stage 2 rectocele (Mellgren's classification) have been included. Twelve (group A) underwent surgery with standard technique and twelve (group B) underwent surgery using the HF Radio Scalpel, which cuts and coagulates tissues without damage thanks to its low working temperature (45-70°C). Read More

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November 2018
13 Reads

Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men: Baseline data from the study of the prevention of anal cancer (SPANC).

Cancer Epidemiol 2019 Feb 12;58:12-16. Epub 2018 Nov 12.

The Kirby Institute, Wallace Wurth Building, UNSW Sydney, Randwick, New South Wales 2031, Australia. Electronic address:

Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated.

Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18777821183039
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http://dx.doi.org/10.1016/j.canep.2018.10.009DOI Listing
February 2019
16 Reads

Five-year prospective evaluation of cytology, HPV testing, and biomarkers for detection of anal precancer in HIV+ MSM.

Clin Infect Dis 2018 Nov 12. Epub 2018 Nov 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.

Background: Human papillomavirus (HPV)-related biomarkers have shown good cross-sectional performance for anal precancer detection in HIV-positive (HIV+) men who have sex with men (MSM). However, the long-term performance and risk stratification of these biomarkers are unknown. Here, we prospectively evaluated high-risk (HR) HPV DNA, HPV16/18 genotyping, HPV E6/E7 mRNA, and p16/Ki-67 dual stain in a population of HIV+ MSM. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
Publisher Site
http://dx.doi.org/10.1093/cid/ciy970DOI Listing
November 2018
11 Reads

Improved anal Cytology Sampling: Tush Brush Compared With Dacron Swab.

J Low Genit Tract Dis 2019 Jan;23(1):48-53

Georgia Cancer Center, Augusta University, Augusta, GA.

Objective: The objective of this study was to determine the performance characteristics of the Tush brush (TB) compared with a saline moistened Dacron swab (DS) as anal cytology sampling devices.

Materials And Methods: TB and DS anal cytology tests were randomly collected from 146 patients presenting for anal cytology. High-resolution anoscopy and biopsies were obtained as indicated. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000447DOI Listing
January 2019
8 Reads

Basic Science, Epidemiology, and Screening for Anal Intraepithelial Neoplasia and Its Relationship to Anal Squamous Cell Cancer.

Clin Colon Rectal Surg 2018 Nov 2;31(6):368-378. Epub 2018 Nov 2.

Section of Colon and Rectal Surgery, LSU Department of Surgery, LSU School of Medicine, New Orleans, Louisiana.

Despite the progress made in the reduction of squamous cell carcinoma of the cervix, the incidence of anal squamous cell carcinoma (ASCC) has been increasing since 1992. While it remains an uncommon disease, the prevalence is climbing steadily. Among human immunodeficiency virus (HIV)-infected adults, especially men who have sex with men, ASCC is one of the more common non-AIDS-defining malignancies. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1668107
Publisher Site
http://dx.doi.org/10.1055/s-0038-1668107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214809PMC
November 2018
10 Reads

Transanal repair of rectocele with high frequency radio scalpel.

G Chir 2018 Sep-Oct;39(5):303-308

Aim: This is a prospective randomized study to analyze results obtained in two groups of patients, affected by stage 2 rectocele and treated with rectum anterior wall repair and strength, performed with standard or modified Khubchandani technique, using High Frequency (HF) Radio Scalpel.

Materials And Methods: A cohort of 24 patients with stage 2 rectocele (Mellgren's classification) have been included. Twelve (group A) underwent surgery with standard technique and twelve (group B) underwent surgery using the HF Radio Scalpel, which cuts and coagulates tissues without damage thanks to its low working temperature (45-70°C). Read More

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October 2018
4 Reads

Testing for Human Papillomavirus Strains 16 and 18 Helps Predict the Presence of Anal High-Grade Squamous Intraepithelial Lesions.

Dis Colon Rectum 2018 12;61(12):1364-1371

Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: More than 90% of anal cancers are caused by human papillomavirus, and human papillomavirus strains 16 and 18 are the most oncogenic. Anal high-grade squamous intraepithelial lesions are cancer precursors. Treating these high-grade intraepithelial lesions likely reduces the risk of cancer, but cytology is an imperfect screening test. Read More

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http://Insights.ovid.com/crossref?an=00003453-900000000-9991
Publisher Site
http://dx.doi.org/10.1097/DCR.0000000000001143DOI Listing
December 2018
4 Reads

What Is the Risk of Anal Carcinoma in Patients With Anal Intraepithelial Neoplasia III?

Dis Colon Rectum 2018 12;61(12):1350-1356

Section of Colon and Rectal Surgery, Division of General and Gastrointestinal Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: The risk of anal carcinoma after previous diagnosis of anal intraepithelial neoplasia III is unclear.

Objective: The purpose of this study was to estimate the risk of anal carcinoma in patients with anal intraepithelial neoplasia III and to identify predictors for subsequent malignancy.

Design: This was a retrospective review using the Surveillance, Epidemiology, and End Results registry (1973-2014). Read More

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http://Insights.ovid.com/crossref?an=00003453-900000000-9991
Publisher Site
http://dx.doi.org/10.1097/DCR.0000000000001219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219933PMC
December 2018
16 Reads

Facilitators of and barriers to high-resolution anoscopy adherence among men who have sex with men: a qualitative study.

Sex Health 2018 Sep 24. Epub 2018 Sep 24.

Anal cancer is a rare malignancy that disproportionately affects men who have sex with men (MSM) and HIV-infected people. Anal cancer is associated with human papillomavirus (HPV) in upward of 90% of cases and is preceded by pre-cancerous changes in cells of the anal canal. High-resolution anoscopy (HRA) is used for the detection, treatment and continued monitoring of anal dysplasia. Read More

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http://dx.doi.org/10.1071/SH18029DOI Listing
September 2018
32 Reads

Anal High-Grade Squamous Intraepithelial Lesions in Pharmacologically Immunocompromised Patients Followed in a Referral Center.

Dis Colon Rectum 2018 11;61(11):1267-1272

Homerton Anal Neoplasia Service, Homerton University Hospital, London, United Kingdom.

Background: Information is lacking regarding anal/perianal precancerous lesions in referral cohorts of pharmacologically immunocompromised patients.

Objective: The aim of this study is to evaluate the prevalence of anal/perianal high-grade squamous intraepithelial lesions in a referral cohort of patients on immunomodulator/immunosuppressive medications, who were assessed and followed with high-resolution anoscopy.

Design: This is a retrospective study. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001214DOI Listing
November 2018
3 Reads

Prevalence of Anal Squamous Intraepithelial Lesions in HIV-1-Infected Young Men Who Have Sex With Men and Transwomen.

J Low Genit Tract Dis 2018 Oct;22(4):340-347

Department of Pediatrics, Division of Pediatric Infectious Diseases, Emory University School of Medicine, Atlanta, GA.

Objective: Anal cancer rates are increasing among HIV-infected persons. Although an efficacious human papillomavirus (HPV) vaccine is available, HPV vaccination rates remain low. Therefore, providers perform anal cancer screening, but there is no consensus on the optimal methods or timing of screening. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158076PMC
October 2018
26 Reads

Virological and Serological Predictors of Anal High-grade Squamous Intraepithelial Lesions Among Human Immunodeficiency Virus-positive Men Who Have Sex With Men.

Clin Infect Dis 2019 Apr;68(8):1377-1387

Department of Infectious Diseases, Public Health Service Amsterdam.

Background: Our objective was to identify virological and serological predictors of anal high-grade squamous intraepithelial lesions (HSIL) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM).

Methods: HIV-positive MSM were recruited from a longitudinal study during which anal self-swabs and serum were collected at up to 5 bi-annual visits. Swabs were human papillomavirus (HPV) genotyped, and the type-specific HPV viral load in the anal swabs was determined. Read More

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http://dx.doi.org/10.1093/cid/ciy719DOI Listing
April 2019
8 Reads

Human Papillomavirus-16 DNA Quantitation Differentiates High-Grade Anal Neoplasia.

Int J Environ Res Public Health 2018 08 8;15(8). Epub 2018 Aug 8.

Hawaii Center for AIDS, Honolulu, HI 96813, USA.

Due to their higher rates of anal dysplasia/cancer, human immunodeficiency virus (HIV)-positive individuals are recommended to undergo anal dysplasia screening, which consists of anal cytology (AC) and high resolution anoscopy (HRA) with anal biopsy (AB) after abnormal AC result. However, AC variability limits its usefulness. Our objective was to evaluate human papillomavirus (HPV)-16 DNA quantitation as part of the screening algorithm. Read More

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http://dx.doi.org/10.3390/ijerph15081690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121871PMC
August 2018
24 Reads

Acceptability of high-resolution anoscopy for anal cancer screening in HIV-infected patients.

HIV Med 2018 11 6;19(10):716-723. Epub 2018 Aug 6.

Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.

Objectives: HIV-infected individuals are at increased risk of anal cancer. Screening for anal cancer precursors using high-resolution anoscopy (HRA) may be clinically beneficial. In this study, we examined patient tolerability of this procedure. Read More

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http://dx.doi.org/10.1111/hiv.12663DOI Listing
November 2018
12 Reads

Interest of cytology combined with Xpert HPV and Anyplex II HPV28 Detection human papillomavirus (HPV) typing: differential profiles of anal and cervical HPV lesions in HIV-infected patients on antiretroviral therapy.

HIV Med 2018 11 30;19(10):698-707. Epub 2018 Jul 30.

Pathology Department, Bichat-Claude Bernard Hospital, Paris, France.

Objectives: The aim of the study was to assess the interest to combine cytological examination and human papillomavirus (HPV) typing of anal and cervical Papanicolaou (Pap) smears of HIV-infected patients on combination antiretroviral therapy (cART), to evaluate whether differences in prevalence exist between anal and cervical squamous intraepithelial lesions in patients with high-risk oncogenic HPV infection.

Methods: Anal and/or cervical Pap smears were obtained by anoscopy and/or colposcopy in 238 subjects recruited consecutively in 2015: anal smears were obtained from 48 male and female patients [42 men; 35 men who have sex with men (MSM)] and cervical smears from 190 female patients. Cytological Bethesda classification was coupled with HPV typing. Read More

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http://doi.wiley.com/10.1111/hiv.12661
Publisher Site
http://dx.doi.org/10.1111/hiv.12661DOI Listing
November 2018
8 Reads

A randomized clinical trial of infrared coagulation ablation versus active monitoring of intra-anal high-grade dysplasia in HIV-infected adults: An AIDS Malignancy Consortium trial.

Clin Infect Dis 2018 Jul 27. Epub 2018 Jul 27.

Associate Professor of Medicine Cornell Clinical Trials Unit New York, NY.

Background: Anal high-grade dysplasia (HSIL) ablation may reduce the incidence of invasive cancer, but few data exist on HSIL treatment efficacy and natural regression without treatment.

Methods: An open-label, randomized, multi-site clinical trial of HIV-infected adults age 27 or older with 1-3 biopsy-proven anal HSIL (index HSIL) without prior history of HSIL treatment with infrared coagulation. Participants were randomized 1:1 to ablation of anal HSIL with infrared coagulation (treatment group) or no HSIL treatment (active monitoring). Read More

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http://dx.doi.org/10.1093/cid/ciy615DOI Listing
July 2018
5 Reads

Human Papillomavirus Genotypes Predict Progression of Anal Low-Grade Squamous Intraepithelial Lesions.

J Infect Dis 2018 Oct;218(11):1746-1752

Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: High-risk human papillomavirus (hrHPV)-induced anal low-grade squamous intraepithelial lesions (LSILs) have the potential to progress to high-grade squamous intraepithelial lesions (HSILs). We investigated whether anal hrHPV infections, particularly types 16 and 18, predict LSIL-to-HSIL progression.

Methods: One hundred forty-six human immunodeficiency virus (HIV)-infected and 22 HIV-uninfected patients with anal LSILs underwent cytology, HPV genotyping (16, 18, and pooled 12 hrHPV types), and high-resolution anoscopy-guided biopsy at baseline and surveillance. Read More

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http://dx.doi.org/10.1093/infdis/jiy463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195660PMC
October 2018
1 Read

Comparison of anal cancer screening strategies including standard anoscopy, anal cytology, and HPV genotyping in HIV-positive men who have sex with men.

Br J Cancer 2018 Aug 20;119(3):381-386. Epub 2018 Jul 20.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Background: There is no consensus on screening strategy of high-grade intraepithelial neoplasia (HGAIN). Guidelines range from clinical examination with digital anorectal examination followed by standard anoscopy (SA), to anal cytology (Pap)+/- HPV genotyping. We compared screening strategy yields based on Pap, SA, and HPV-16 genotyping alone or in combination in HIV-MSM. Read More

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http://dx.doi.org/10.1038/s41416-018-0176-9DOI Listing
August 2018
7 Reads

Biomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions.

AIDS 2018 Oct;32(16):2309-2316

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objectives: The aim of this study was to determine whether biomarker P16 predicts progression risk for anal low-grade squamous intraepithelial lesions (LSILs).

Design: A retrospective study.

Methods: One hundred and nine HIV-infected and 18 HIV-uninfected patients with biopsy-proven anal LSIL at initial screening underwent surveillance high-resolution anoscopy and biopsy within 2 years of diagnosis. Read More

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http://dx.doi.org/10.1097/QAD.0000000000001957DOI Listing
October 2018
7 Reads

Determinants of high-grade anal intraepithelial lesions in HIV-positive MSM.

AIDS 2018 Oct;32(16):2363-2371

Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon.

Objective: To assess determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive men who have sex with men (MSM), a population at high-risk of HPV-related anal cancer.

Design: APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged at least 35 years in six centres across France.

Methods: At baseline, participants underwent high-resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA. Read More

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http://Insights.ovid.com/crossref?an=00002030-900000000-9714
Publisher Site
http://dx.doi.org/10.1097/QAD.0000000000001947DOI Listing
October 2018
3 Reads

Anal HPV infection and correlates in HIV-infected patients attending a Sexually Transmitted Infection clinic in Brazil.

PLoS One 2018 5;13(7):e0199058. Epub 2018 Jul 5.

Post-Graduation Program in Infectious Diseases, Federal University of Espírito Santo, Vitoria, Brazil.

Objective: To estimate the prevalence of anal HPV infection, genotype distribution, intraepithelial neoplasia (AIN) and correlates in a cohort of HIV-infected patients attending at Sexually Transmitted Infections (STI) clinic in Brazil.

Study Design: A descriptive analysis was performed which includes, demographic, behavioral and clinical data. Anal specimens from HIV-positive men and women were collected during a regular visit and they were used for cytology and histopathology tests, as well as for HPV molecular identification. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199058PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033400PMC
December 2018
3 Reads

Factors associated with anal cancer screening follow-up by high-resolution anoscopy.

Sex Transm Infect 2019 03 22;95(2):83-86. Epub 2018 Jun 22.

Fenway Health, The Fenway Institute, Boston, Massachusetts, USA.

Objectives: High-resolution anoscopy (HRA) is a potential screening method for detection of anal cancer precursors. We evaluated factors associated with adherence to recommended HRA follow-up time intervals among men who have sex with men (MSM).

Methods: We employed a retrospective, observational cohort study with 155 MSM screened by HRA between 1 April 2011 and 31 March 2016 at a Federally Qualified Health Centre in Boston, Massachusetts. Read More

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http://dx.doi.org/10.1136/sextrans-2017-053515DOI Listing
March 2019
7 Reads

Digital Rectal Examination and Anoscopy.

N Engl J Med 2018 May;378(22):e30

From Brigham and Women's Hospital, Harvard Medical School (T.K.R., A.V.K.), and Massachusetts General Hospital (L.G.B.) - both in Boston; the University of Tübingen, Tübingen, Germany (H.R.); and Changzheng Hospital, Second Military Medical University, Shanghai, China (H.Z.).

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http://dx.doi.org/10.1056/NEJMvcm1510280DOI Listing
May 2018
2 Reads

Detection Rate of High-Grade Squamous Intraepithelial Lesions as a Quality Assurance Metric for High-Resolution Anoscopy in HIV-Positive Men.

Dis Colon Rectum 2018 Jul;61(7):780-786

Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: High-resolution anoscopy-guided biopsies are the gold standard for identifying anal intraepithelial neoplasia, but diagnosing high-grade squamous intraepithelial lesions depends on the skills of the anoscopist.

Objective: This study aims to validate the high-grade squamous intraepithelial lesion detection rate as a quality assurance metric for high-resolution anoscopy in HIV-positive men.

Design: This is a retrospective study. Read More

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http://Insights.ovid.com/crossref?an=00003453-900000000-9994
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http://dx.doi.org/10.1097/DCR.0000000000001039DOI Listing
July 2018
15 Reads

The acceptability of high resolution anoscopy examination in patients attending a tertiary referral centre.

BMC Cancer 2018 May 11;18(1):554. Epub 2018 May 11.

Homerton Anal Neoplasia Service, Homerton University Hospital NHS Foundation Trust, London, E9 6SR, UK.

Background: High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination and ablative treatment under local anaesthetic. Read More

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http://dx.doi.org/10.1186/s12885-018-4475-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946412PMC
May 2018
13 Reads

Performance of Anal Cytology Compared With High-Resolution Anoscopy and Histology in Women With Lower Anogenital Tract Neoplasia.

Clin Infect Dis 2018 Sep;67(8):1262-1268

Homerton Anal Neoplasia Service, Homerton University Hospital, London, United Kingdom.

Background: Information on the performance of anal cytology in women who are high risk for human papillomavirus-related lesions and the factors that might influence cytology are largely lacking.

Methods: Retrospective study including all new referrals of women with a previous history of anogenital neoplasia from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies.

Results: Six hundred and thirty six anal cytology samples and 323 biopsies obtained from 278 women were included. Read More

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http://dx.doi.org/10.1093/cid/ciy273DOI Listing
September 2018
3 Reads

Anal Cytology: Institutional Statistics, Correlation With Histology, and Development of Multidisciplinary Screening Program With Review of the Current Literature.

Arch Pathol Lab Med 2019 Jan 13;143(1):23-29. Epub 2018 Apr 13.

From the Department of Pathology, Northwestern Memorial Hospital, Chicago, Illinois.

Context.—: The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy. Read More

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http://dx.doi.org/10.5858/arpa.2017-0242-RADOI Listing
January 2019
4 Reads

Factors Associated with High-Grade Anal Intraepithelial Lesion in HIV-Positive Men in a Southern U.S. City.

AIDS Res Hum Retroviruses 2018 07 2;34(7):598-602. Epub 2018 May 2.

3 Grady Ponce de Leon Center , Atlanta, Georgia .

The incidence of anal cancer is increased in HIV-infected patients compared with the general population. Risk factors associated with the anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), have not been extensively studied in an urban black population with late-stage HIV disease. We performed a retrospective chart review of HIV-infected men at the Grady Ponce de Leon Center HIV Clinic (Atlanta, GA) referred for high-resolution anoscopy (HRA), a procedure where anal tissue is examined under magnification and abnormal areas are biopsied. Read More

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http://dx.doi.org/10.1089/AID.2018.0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025845PMC
July 2018
10 Reads

High-grade anal intraepithelial neoplasia is associated with HIV-1 RNA rectal shedding in virologically suppressed MSM.

AIDS 2018 May;32(8):1017-1024

Infectious Diseases Unit, Hospital General de Elche & Universidad Miguel Hernández.

Objective: The protective effect of ART has not yet been definitively established in MSM. We aimed to characterize the factors associated with persistent HIV-1 RNA rectal shedding.

Methods: Prospective study including virologically suppressed MSM from an HIV cohort. Read More

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http://dx.doi.org/10.1097/QAD.0000000000001794DOI Listing
May 2018
11 Reads

High Baseline Anal Human Papillomavirus and Abnormal Anal Cytology in a Phase 3 Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Individuals Older Than 26 Years: ACTG 5298.

Sex Transm Dis 2018 04;45(4):266-271

Background: The quadrivalent human papillomavirus (HPV) vaccine (qHPV; types 6, 11, 16, 18) is indicated for men and women aged 9 to 26 years to prevent HPV associated anogenital high-grade squamous intraepithelial lesions (HSIL) and cancer. ACTG 5298 was a randomized placebo controlled Phase 3 study in human immunodeficiency virus (HIV)-infected men who have sex with men, and women of qHPV to prevent persistent anal HPV infection. Baseline data are presented here. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868482PMC
April 2018
14 Reads

Anal and Cervical High-Risk Human Papillomavirus Genotyping in Women With and Without Genital Neoplasia.

J Low Genit Tract Dis 2018 Apr;22(2):115-119

Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Objective: The aim of the study was to compare the prevalence, genotypes, and rates of concomitant anal and cervical high-risk human papillomavirus (HR-HPV) in women with and without a history of HPV-related genital neoplasia.

Materials And Methods: This was a prospective cohort study conducted from December 2012 to February 2014. Women with a history of neoplasia were considered the high-risk group. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000368DOI Listing
April 2018
13 Reads

Antiretroviral therapy suppresses rectal HIV-RNA shedding despite inflammation in MSM with rectal and infections-a cross-sectional, single-center study.

Sex Transm Infect 2019 03 3;95(2):95-98. Epub 2018 Feb 3.

Department of Dermatology, University Hospital, University of Duisburg-Essen, Essen, Germany.

Objectives: Rectal infections with and/or (CT/NG) are common in men who have sex with men (MSM) and are linked to HIV transmission. However, rectal CT/NG infections are often asymptomatic and it is not known how they contribute to HIV transmission. We assessed clinical and cytological signs of inflammation as well as rectal HIV-RNA in HIV-infected MSM with and without CT/NG infection. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2017-053409
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http://dx.doi.org/10.1136/sextrans-2017-053409DOI Listing
March 2019
24 Reads

Prevalence and Risk Factors for Anal Human Papillomavirus Infection in Human Immunodeficiency Virus-Positive Men Who Have Sex with Men.

J Infect Dis 2018 Apr;217(10):1535-1543

Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon, Paris, France.

Background: We assessed prevalence and risk factors for anal human papillomavirus (HPV) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), who are at high-risk of HPV-related anal cancer.

Methods: APACHES is a multicentric, prospective study of anal HPV infection and lesions in HIV-positive MSM aged ≥35 years. At baseline, participants underwent anal swabs for HPV and cytology, plus high-resolution anoscopy. Read More

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http://dx.doi.org/10.1093/infdis/jiy059DOI Listing
April 2018
15 Reads

High prevalence and incidence of HPV-related anal cancer precursor lesions in HIV-positive women in the late HAART era.

Enferm Infecc Microbiol Clin 2018 11 6;36(9):555-562. Epub 2017 Dec 6.

Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen de las Nieves, Granada, España.

Introduction: Anal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV).

Objectives: To evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection.

Patients And Methods: Prospective-longitudinal study (May 2012-December 2016). Read More

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http://dx.doi.org/10.1016/j.eimc.2017.10.014DOI Listing
November 2018
11 Reads

Significance of the Cytological Signs of Human Papillomavirus Infection in Anal Pap Smears of Human Immunodeficiency Virus-Infected Japanese Men Who Have Sex with Men

Asian Pac J Cancer Prev 2017 11 26;18(11):3173-3178. Epub 2017 Nov 26.

School of Medical Technology, Faculty of Health Science, Gunma Paz University, Japan. Email:

Purpose: The incidence of invasive anal cancer (IAC) has been increasing among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). Although cytological diagnosis is the modality of choice for screening cases of IAC, it is associated with lower sensitivity and specificity. Therefore, the present study aimed to evaluate new cytological signs of human papillomavirus (HPV) infection that may contribute to improving anal cytology. Read More

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http://dx.doi.org/10.22034/APJCP.2017.18.11.3173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773808PMC
November 2017
11 Reads