397 results match your criteria Anoscopy


Effect of an Educational Video to Increase Calls and Screening into an Anal Cancer Clinical Trial Among HIV+ Hispanics in PR: Results from a Randomized Controlled Behavioral Trial.

AIDS Behav 2018 Nov 22. Epub 2018 Nov 22.

Cancer Control and Population Sciences Program, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico.

Anal cancer incidence is higher in persons living with HIV/AIDS (PLWHA) than in the general population. Participation of PLWHA in anal cancer clinical trials (CTs) is essential; Hispanic PLWHA are underrepresented in CTs. We conducted a behavioral CT among 305 PLWHA in Puerto Rico to measure the efficacy of an educational video in increasing calls and screening into an anal cancer CT. Read More

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November 2018
1 Read

History of High-Resolution Anoscopy.

Clin Colon Rectal Surg 2018 Nov 2;31(6):336-346. Epub 2018 Nov 2.

Department of General Surgery, University of Washington, Seattle, Washington.

High-resolution anoscopy (HRA) is a form of low-resolution anal microscopy currently utilized in the screening and management of anal squamous dysplasia. No randomized controlled trials, national or international guidelines exist on the use of HRA for this purpose. Much of our understanding of this entity has been adapted from the literature on cervical squamous dysplasia, including the technique of HRA itself. Read More

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November 2018
3 Reads

Transanal repair of rectocele with high frequency radio scalpel.

G Chir 2018 Sep-Oct;34(5):303-308

Aim: This is a prospective randomized study to analyze results obtained in two groups of patients, affected by stage 2 rectocele and treated with rectum anterior wall repair and strength, performed with standard or modified Khubchandani technique, using High Frequency (HF) Radio Scalpel.

Materials And Methods: A cohort of 24 patients with stage 2 rectocele (Mellgren's classification) have been included. Twelve (group A) underwent surgery with standard technique and twelve (group B) underwent surgery using the HF Radio Scalpel, which cuts and coagulates tissues without damage thanks to its low working temperature (45-70°C). Read More

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November 2018
5 Reads

Association of anal symptoms with anal high grade squamous intraepithelial lesions (HSIL) among men who have sex with men: Baseline data from the study of the prevention of anal cancer (SPANC).

Cancer Epidemiol 2018 Nov 12;58:12-16. Epub 2018 Nov 12.

The Kirby Institute, Wallace Wurth Building, UNSW Sydney, Randwick, New South Wales 2031, Australia. Electronic address:

Background: The association between anal high-grade squamous intraepithelial lesion (HSIL) and anal symptoms has not been systematically investigated.

Methods: The Study of Prevention of Anal Cancer is a prospective cohort study of men who have sex with men (MSM) ≥ 35 years old in Sydney, Australia. Self-reported symptoms were collected. Read More

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November 2018
7 Reads

Five-year prospective evaluation of cytology, HPV testing, and biomarkers for detection of anal precancer in HIV+ MSM.

Clin Infect Dis 2018 Nov 12. Epub 2018 Nov 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.

Background: Human papillomavirus (HPV)-related biomarkers have shown good cross-sectional performance for anal precancer detection in HIV-positive (HIV+) men who have sex with men (MSM). However, the long-term performance and risk stratification of these biomarkers are unknown. Here, we prospectively evaluated high-risk (HR) HPV DNA, HPV16/18 genotyping, HPV E6/E7 mRNA, and p16/Ki-67 dual stain in a population of HIV+ MSM. Read More

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November 2018
2 Reads

Improved anal Cytology Sampling: Tush Brush Compared With Dacron Swab.

J Low Genit Tract Dis 2018 Nov 7. Epub 2018 Nov 7.

Georgia Cancer Center, Augusta University, Augusta, GA.

Objective: The objective of this study was to determine the performance characteristics of the Tush brush (TB) compared with a saline moistened Dacron swab (DS) as anal cytology sampling devices.

Materials And Methods: TB and DS anal cytology tests were randomly collected from 146 patients presenting for anal cytology. High-resolution anoscopy and biopsies were obtained as indicated. Read More

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November 2018
1 Read

Basic Science, Epidemiology, and Screening for Anal Intraepithelial Neoplasia and Its Relationship to Anal Squamous Cell Cancer.

Clin Colon Rectal Surg 2018 Nov 2;31(6):368-378. Epub 2018 Nov 2.

Section of Colon and Rectal Surgery, LSU Department of Surgery, LSU School of Medicine, New Orleans, Louisiana.

Despite the progress made in the reduction of squamous cell carcinoma of the cervix, the incidence of anal squamous cell carcinoma (ASCC) has been increasing since 1992. While it remains an uncommon disease, the prevalence is climbing steadily. Among human immunodeficiency virus (HIV)-infected adults, especially men who have sex with men, ASCC is one of the more common non-AIDS-defining malignancies. Read More

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November 2018
5 Reads

Transanal repair of rectocele with high frequency radio scalpel.

G Chir 2018 Sep-Oct;39(5):303-308

Aim: This is a prospective randomized study to analyze results obtained in two groups of patients, affected by stage 2 rectocele and treated with rectum anterior wall repair and strength, performed with standard or modified Khubchandani technique, using High Frequency (HF) Radio Scalpel.

Materials And Methods: A cohort of 24 patients with stage 2 rectocele (Mellgren's classification) have been included. Twelve (group A) underwent surgery with standard technique and twelve (group B) underwent surgery using the HF Radio Scalpel, which cuts and coagulates tissues without damage thanks to its low working temperature (45-70°C). Read More

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October 2018
2 Reads

Testing for Human Papillomavirus Strains 16 and 18 Helps Predict the Presence of Anal High-Grade Squamous Intraepithelial Lesions.

Dis Colon Rectum 2018 Dec;61(12):1364-1371

Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: More than 90% of anal cancers are caused by human papillomavirus, and human papillomavirus strains 16 and 18 are the most oncogenic. Anal high-grade squamous intraepithelial lesions are cancer precursors. Treating these high-grade intraepithelial lesions likely reduces the risk of cancer, but cytology is an imperfect screening test. Read More

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December 2018
3 Reads

What Is the Risk of Anal Carcinoma in Patients With Anal Intraepithelial Neoplasia III?

Dis Colon Rectum 2018 Dec;61(12):1350-1356

Section of Colon and Rectal Surgery, Division of General and Gastrointestinal Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: The risk of anal carcinoma after previous diagnosis of anal intraepithelial neoplasia III is unclear.

Objective: The purpose of this study was to estimate the risk of anal carcinoma in patients with anal intraepithelial neoplasia III and to identify predictors for subsequent malignancy.

Design: This was a retrospective review using the Surveillance, Epidemiology, and End Results registry (1973-2014). Read More

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December 2018
8 Reads

Facilitators of and barriers to high-resolution anoscopy adherence among men who have sex with men: a qualitative study.

Sex Health 2018 Sep 24. Epub 2018 Sep 24.

Anal cancer is a rare malignancy that disproportionately affects men who have sex with men (MSM) and HIV-infected people. Anal cancer is associated with human papillomavirus (HPV) in upward of 90% of cases and is preceded by pre-cancerous changes in cells of the anal canal. High-resolution anoscopy (HRA) is used for the detection, treatment and continued monitoring of anal dysplasia. Read More

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September 2018
13 Reads

Anal High-Grade Squamous Intraepithelial Lesions in Pharmacologically Immunocompromised Patients Followed in a Referral Center.

Dis Colon Rectum 2018 11;61(11):1267-1272

Homerton Anal Neoplasia Service, Homerton University Hospital, London, United Kingdom.

Background: Information is lacking regarding anal/perianal precancerous lesions in referral cohorts of pharmacologically immunocompromised patients.

Objective: The aim of this study is to evaluate the prevalence of anal/perianal high-grade squamous intraepithelial lesions in a referral cohort of patients on immunomodulator/immunosuppressive medications, who were assessed and followed with high-resolution anoscopy.

Design: This is a retrospective study. Read More

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November 2018
1 Read

Prevalence of Anal Squamous Intraepithelial Lesions in HIV-1-Infected Young Men Who Have Sex With Men and Transwomen.

J Low Genit Tract Dis 2018 Oct;22(4):340-347

Department of Pediatrics, Division of Pediatric Infectious Diseases, Emory University School of Medicine, Atlanta, GA.

Objective: Anal cancer rates are increasing among HIV-infected persons. Although an efficacious human papillomavirus (HPV) vaccine is available, HPV vaccination rates remain low. Therefore, providers perform anal cancer screening, but there is no consensus on the optimal methods or timing of screening. Read More

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October 2018
13 Reads

Virological and serological predictors of anal high-grade squamous intraepithelial lesions among HIV-positive men who have sex with men.

Clin Infect Dis 2018 Aug 28. Epub 2018 Aug 28.

Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.

Background: Our objective was to identify virological and serological predictors of anal high-grade squamous intraepithelial lesions (HSIL) in HIV-positive men-who-have-sex-with-men (MSM).

Methods: HIV-positive MSM were recruited from a longitudinal study (2010-2013), during which anal self-swabs and serum were collected at up to five bi-annual visits. Swabs were HPV genotyped, and type-specific HPV viral load in anal swabs was determined. Read More

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August 2018
4 Reads

Human Papillomavirus-16 DNA Quantitation Differentiates High-Grade Anal Neoplasia.

Int J Environ Res Public Health 2018 08 8;15(8). Epub 2018 Aug 8.

Hawaii Center for AIDS, Honolulu, HI 96813, USA.

Due to their higher rates of anal dysplasia/cancer, human immunodeficiency virus (HIV)-positive individuals are recommended to undergo anal dysplasia screening, which consists of anal cytology (AC) and high resolution anoscopy (HRA) with anal biopsy (AB) after abnormal AC result. However, AC variability limits its usefulness. Our objective was to evaluate human papillomavirus (HPV)-16 DNA quantitation as part of the screening algorithm. Read More

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August 2018
12 Reads

Acceptability of high-resolution anoscopy for anal cancer screening in HIV-infected patients.

HIV Med 2018 Nov 6;19(10):716-723. Epub 2018 Aug 6.

Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.

Objectives: HIV-infected individuals are at increased risk of anal cancer. Screening for anal cancer precursors using high-resolution anoscopy (HRA) may be clinically beneficial. In this study, we examined patient tolerability of this procedure. Read More

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November 2018
7 Reads

Interest of cytology combined with Xpert HPV and Anyplex II HPV28 Detection human papillomavirus (HPV) typing: differential profiles of anal and cervical HPV lesions in HIV-infected patients on antiretroviral therapy.

HIV Med 2018 Nov 30;19(10):698-707. Epub 2018 Jul 30.

Pathology Department, Bichat-Claude Bernard Hospital, Paris, France.

Objectives: The aim of the study was to assess the interest to combine cytological examination and human papillomavirus (HPV) typing of anal and cervical Papanicolaou (Pap) smears of HIV-infected patients on combination antiretroviral therapy (cART), to evaluate whether differences in prevalence exist between anal and cervical squamous intraepithelial lesions in patients with high-risk oncogenic HPV infection.

Methods: Anal and/or cervical Pap smears were obtained by anoscopy and/or colposcopy in 238 subjects recruited consecutively in 2015: anal smears were obtained from 48 male and female patients [42 men; 35 men who have sex with men (MSM)] and cervical smears from 190 female patients. Cytological Bethesda classification was coupled with HPV typing. Read More

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November 2018
6 Reads

A randomized clinical trial of infrared coagulation ablation versus active monitoring of intra-anal high-grade dysplasia in HIV-infected adults: An AIDS Malignancy Consortium trial.

Clin Infect Dis 2018 Jul 27. Epub 2018 Jul 27.

Associate Professor of Medicine Cornell Clinical Trials Unit New York, NY.

Background: Anal high-grade dysplasia (HSIL) ablation may reduce the incidence of invasive cancer, but few data exist on HSIL treatment efficacy and natural regression without treatment.

Methods: An open-label, randomized, multi-site clinical trial of HIV-infected adults age 27 or older with 1-3 biopsy-proven anal HSIL (index HSIL) without prior history of HSIL treatment with infrared coagulation. Participants were randomized 1:1 to ablation of anal HSIL with infrared coagulation (treatment group) or no HSIL treatment (active monitoring). Read More

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July 2018
3 Reads

Human Papillomavirus Genotypes Predict Progression of Anal Low-Grade Squamous Intraepithelial Lesions.

J Infect Dis 2018 Oct;218(11):1746-1752

Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: High-risk human papillomavirus (hrHPV)-induced anal low-grade squamous intraepithelial lesions (LSILs) have the potential to progress to high-grade squamous intraepithelial lesions (HSILs). We investigated whether anal hrHPV infections, particularly types 16 and 18, predict LSIL-to-HSIL progression.

Methods: One hundred forty-six human immunodeficiency virus (HIV)-infected and 22 HIV-uninfected patients with anal LSILs underwent cytology, HPV genotyping (16, 18, and pooled 12 hrHPV types), and high-resolution anoscopy-guided biopsy at baseline and surveillance. Read More

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October 2018

Comparison of anal cancer screening strategies including standard anoscopy, anal cytology, and HPV genotyping in HIV-positive men who have sex with men.

Br J Cancer 2018 Aug 20;119(3):381-386. Epub 2018 Jul 20.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Background: There is no consensus on screening strategy of high-grade intraepithelial neoplasia (HGAIN). Guidelines range from clinical examination with digital anorectal examination followed by standard anoscopy (SA), to anal cytology (Pap)+/- HPV genotyping. We compared screening strategy yields based on Pap, SA, and HPV-16 genotyping alone or in combination in HIV-MSM. Read More

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August 2018
3 Reads

Biomarker P16 predicts progression risk of anal low-grade squamous intraepithelial lesions.

AIDS 2018 Oct;32(16):2309-2316

Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objectives: The aim of this study was to determine whether biomarker P16 predicts progression risk for anal low-grade squamous intraepithelial lesions (LSILs).

Design: A retrospective study.

Methods: One hundred and nine HIV-infected and 18 HIV-uninfected patients with biopsy-proven anal LSIL at initial screening underwent surveillance high-resolution anoscopy and biopsy within 2 years of diagnosis. Read More

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October 2018
3 Reads

Determinants of high-grade anal intraepithelial lesions in HIV-positive MSM.

AIDS 2018 Oct;32(16):2363-2371

Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon.

Objective: To assess determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive men who have sex with men (MSM), a population at high-risk of HPV-related anal cancer.

Design: APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged at least 35 years in six centres across France.

Methods: At baseline, participants underwent high-resolution anoscopy (HRA) with biopsy of suspicious lesions, preceded by anal swabs for liquid-based cytology, p16/Ki67 immunostaining, and HPV DNA. Read More

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October 2018
2 Reads

Anal HPV infection and correlates in HIV-infected patients attending a Sexually Transmitted Infection clinic in Brazil.

PLoS One 2018 5;13(7):e0199058. Epub 2018 Jul 5.

Post-Graduation Program in Infectious Diseases, Federal University of Espírito Santo, Vitoria, Brazil.

Objective: To estimate the prevalence of anal HPV infection, genotype distribution, intraepithelial neoplasia (AIN) and correlates in a cohort of HIV-infected patients attending at Sexually Transmitted Infections (STI) clinic in Brazil.

Study Design: A descriptive analysis was performed which includes, demographic, behavioral and clinical data. Anal specimens from HIV-positive men and women were collected during a regular visit and they were used for cytology and histopathology tests, as well as for HPV molecular identification. Read More

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July 2018
1 Read

Factors associated with anal cancer screening follow-up by high-resolution anoscopy.

Sex Transm Infect 2018 Jun 22. Epub 2018 Jun 22.

Fenway Health, The Fenway Institute, Boston, Massachusetts, USA.

Objectives: High-resolution anoscopy (HRA) is a potential screening method for detection of anal cancer precursors. We evaluated factors associated with adherence to recommended HRA follow-up time intervals among men who have sex with men (MSM).

Methods: We employed a retrospective, observational cohort study with 155 MSM screened by HRA between 1 April 2011 and 31 March 2016 at a Federally Qualified Health Centre in Boston, Massachusetts. Read More

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June 2018
6 Reads

Digital Rectal Examination and Anoscopy.

N Engl J Med 2018 May;378(22):e30

From Brigham and Women's Hospital, Harvard Medical School (T.K.R., A.V.K.), and Massachusetts General Hospital (L.G.B.) - both in Boston; the University of Tübingen, Tübingen, Germany (H.R.); and Changzheng Hospital, Second Military Medical University, Shanghai, China (H.Z.).

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Detection Rate of High-Grade Squamous Intraepithelial Lesions as a Quality Assurance Metric for High-Resolution Anoscopy in HIV-Positive Men.

Dis Colon Rectum 2018 Jul;61(7):780-786

Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: High-resolution anoscopy-guided biopsies are the gold standard for identifying anal intraepithelial neoplasia, but diagnosing high-grade squamous intraepithelial lesions depends on the skills of the anoscopist.

Objective: This study aims to validate the high-grade squamous intraepithelial lesion detection rate as a quality assurance metric for high-resolution anoscopy in HIV-positive men.

Design: This is a retrospective study. Read More

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July 2018
8 Reads

The acceptability of high resolution anoscopy examination in patients attending a tertiary referral centre.

BMC Cancer 2018 May 11;18(1):554. Epub 2018 May 11.

Homerton Anal Neoplasia Service, Homerton University Hospital NHS Foundation Trust, London, E9 6SR, UK.

Background: High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination and ablative treatment under local anaesthetic. Read More

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May 2018
3 Reads

Performance of Anal Cytology Compared With High-Resolution Anoscopy and Histology in Women With Lower Anogenital Tract Neoplasia.

Clin Infect Dis 2018 Sep;67(8):1262-1268

Homerton Anal Neoplasia Service, Homerton University Hospital, London, United Kingdom.

Background: Information on the performance of anal cytology in women who are high risk for human papillomavirus-related lesions and the factors that might influence cytology are largely lacking.

Methods: Retrospective study including all new referrals of women with a previous history of anogenital neoplasia from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies.

Results: Six hundred and thirty six anal cytology samples and 323 biopsies obtained from 278 women were included. Read More

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September 2018
2 Reads

Anal Cytology: Institutional Statistics, Correlation With Histology, and Development of Multidisciplinary Screening Program With Review of the Current Literature.

Arch Pathol Lab Med 2018 Apr 13. Epub 2018 Apr 13.

From the Department of Pathology, Northwestern Memorial Hospital, Chicago, Illinois.

Context: - The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy.

Objective: - To review our experience and the current literature to create, in cooperation with clinicians, a standardized screening and treatment algorithm given our large volume of APTs. Read More

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April 2018
1 Read

Factors Associated with High-Grade Anal Intraepithelial Lesion in HIV-Positive Men in a Southern U.S. City.

AIDS Res Hum Retroviruses 2018 Jul 2;34(7):598-602. Epub 2018 May 2.

3 Grady Ponce de Leon Center , Atlanta, Georgia .

The incidence of anal cancer is increased in HIV-infected patients compared with the general population. Risk factors associated with the anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), have not been extensively studied in an urban black population with late-stage HIV disease. We performed a retrospective chart review of HIV-infected men at the Grady Ponce de Leon Center HIV Clinic (Atlanta, GA) referred for high-resolution anoscopy (HRA), a procedure where anal tissue is examined under magnification and abnormal areas are biopsied. Read More

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July 2018
3 Reads

High-grade anal intraepithelial neoplasia is associated with HIV-1 RNA rectal shedding in virologically suppressed MSM.

AIDS 2018 May;32(8):1017-1024

Infectious Diseases Unit, Hospital General de Elche & Universidad Miguel Hernández.

Objective: The protective effect of ART has not yet been definitively established in MSM. We aimed to characterize the factors associated with persistent HIV-1 RNA rectal shedding.

Methods: Prospective study including virologically suppressed MSM from an HIV cohort. Read More

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May 2018
4 Reads

High Baseline Anal Human Papillomavirus and Abnormal Anal Cytology in a Phase 3 Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Individuals Older Than 26 Years: ACTG 5298.

Sex Transm Dis 2018 Apr;45(4):266-271

Background: The quadrivalent human papillomavirus (HPV) vaccine (qHPV; types 6, 11, 16, 18) is indicated for men and women aged 9 to 26 years to prevent HPV associated anogenital high-grade squamous intraepithelial lesions (HSIL) and cancer. ACTG 5298 was a randomized placebo controlled Phase 3 study in human immunodeficiency virus (HIV)-infected men who have sex with men, and women of qHPV to prevent persistent anal HPV infection. Baseline data are presented here. Read More

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April 2018
9 Reads

Anal and Cervical High-Risk Human Papillomavirus Genotyping in Women With and Without Genital Neoplasia.

J Low Genit Tract Dis 2018 Apr;22(2):115-119

Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Objective: The aim of the study was to compare the prevalence, genotypes, and rates of concomitant anal and cervical high-risk human papillomavirus (HR-HPV) in women with and without a history of HPV-related genital neoplasia.

Materials And Methods: This was a prospective cohort study conducted from December 2012 to February 2014. Women with a history of neoplasia were considered the high-risk group. Read More

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April 2018
6 Reads

Antiretroviral therapy suppresses rectal HIV-RNA shedding despite inflammation in MSM with rectal and infections-a cross-sectional, single-center study.

Sex Transm Infect 2018 Feb 3. Epub 2018 Feb 3.

Department of Dermatology, University Hospital, University of Duisburg-Essen, Essen, Germany.

Objectives: Rectal infections with and/or (CT/NG) are common in men who have sex with men (MSM) and are linked to HIV transmission. However, rectal CT/NG infections are often asymptomatic and it is not known how they contribute to HIV transmission. We assessed clinical and cytological signs of inflammation as well as rectal HIV-RNA in HIV-infected MSM with and without CT/NG infection. Read More

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February 2018
6 Reads

Prevalence and Risk Factors for Anal Human Papillomavirus Infection in Human Immunodeficiency Virus-Positive Men Who Have Sex with Men.

J Infect Dis 2018 Apr;217(10):1535-1543

Service de Proctologie Médico-Interventionnelle, Groupe Hospitalier Diaconesses Croix-Saint-Simon, Paris, France.

Background: We assessed prevalence and risk factors for anal human papillomavirus (HPV) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), who are at high-risk of HPV-related anal cancer.

Methods: APACHES is a multicentric, prospective study of anal HPV infection and lesions in HIV-positive MSM aged ≥35 years. At baseline, participants underwent anal swabs for HPV and cytology, plus high-resolution anoscopy. Read More

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April 2018
6 Reads

High prevalence and incidence of HPV-related anal cancer precursor lesions in HIV-positive women in the late HAART era.

Enferm Infecc Microbiol Clin 2018 11 6;36(9):555-562. Epub 2017 Dec 6.

Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen de las Nieves, Granada, España.

Introduction: Anal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV).

Objectives: To evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection.

Patients And Methods: Prospective-longitudinal study (May 2012-December 2016). Read More

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November 2018
7 Reads

Significance of the Cytological Signs of Human Papillomavirus Infection in Anal Pap Smears of Human Immunodeficiency Virus-Infected Japanese Men Who Have Sex with Men

Asian Pac J Cancer Prev 2017 11 26;18(11):3173-3178. Epub 2017 Nov 26.

School of Medical Technology, Faculty of Health Science, Gunma Paz University, Japan. Email:

Purpose: The incidence of invasive anal cancer (IAC) has been increasing among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). Although cytological diagnosis is the modality of choice for screening cases of IAC, it is associated with lower sensitivity and specificity. Therefore, the present study aimed to evaluate new cytological signs of human papillomavirus (HPV) infection that may contribute to improving anal cytology. Read More

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November 2017
9 Reads

Anal cytology, histopathology and anoscopy in an anal dysplasia screening program: is anal cytology enough?

Rev Esp Enferm Dig 2018 Feb;110(2):109-114

Gastrenterologia, Centro Hospitalar São João, Portugal.

Background And Aim: The human papilloma virus is the leading cause of anal squamous cell carcinoma. Cytological screening may reduce the associated morbidity and mortality. The aim of the study was to estimate the agreement between anal cytological examination, histopathology and anoscopic visual impression. Read More

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February 2018
4 Reads

A Pilot Study of the Prevalence of Anal Human Papillomavirus and Dysplasia in a Cohort of Patients With IBD.

Dis Colon Rectum 2017 Dec;60(12):1307-1313

1 Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 2 Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 3 University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 4 Alpha StatConsult, Damascus, Maryland 5 Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Defective cell-mediated immunity increases the risk of human papillomavirus-associated anal dysplasia and cancer. There is limited information on anal canal disease in patients with IBD.

Objective: The purpose of this study was to assess anal/vaginal human papillomavirus and anal dysplasia prevalence in patients with IBD. Read More

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December 2017
11 Reads

Liver transplant recipients have a higher prevalence of anal squamous intraepithelial lesions.

Br J Cancer 2017 Dec 31;117(12):1761-1767. Epub 2017 Oct 31.

Gastroenterology Department Centro Hospitalar São João, Porto, Portugal.

Background: Anal squamous intraepithelial lesions (ASIL) are precancerous lesions of anal squamous cell carcinoma, with a higher prevalence in immunosuppressed patients. There are some studies in kidney transplant recipients, but there is no information regarding prevalence in liver transplantation. Our aim was to evaluate the prevalence of ASIL in this setting. Read More

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December 2017
2 Reads

Cross-sectional study of anal intraepithelial lesions in women with cervical neoplasia without HIV.

Int J Gynaecol Obstet 2018 Feb 22;140(2):233-240. Epub 2017 Nov 22.

Department of Women's Health, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, PE, Brazil.

Objective: To evaluate the prevalence of anal intraepithelial lesions and associated risk factors in women with cervical neoplasia.

Methods: The present cross-sectional study enrolled patients with intraepithelial or invasive cervical neoplasia who had been referred to the lower genital tract pathology outpatient department of the Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil, between December 1, 2008, and December 31, 2009; patients with HIV infections were excluded. Read More

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February 2018
1 Read

Prevalence and risk factors associated with high-grade anal squamous intraepithelial lesions (HSIL)-AIN2 and HSIL-AIN3 in homosexual men.

Papillomavirus Res 2016 12 24;2:97-105. Epub 2016 May 24.

HIV Epidemiology and Prevention Program, The Kirby Institute for infection and immunity in society, University of New South Wales, Sydney, Australia. Electronic address:

Background: Anal intraepithelial neoplasia grade 2 (AIN2) and AIN grade 3 (AIN3) are commonly grouped together as high grade squamous intraepithelial lesions (HSIL). We assessed risk factors for HSIL-AIN2 and HSIL-AIN3 in a cohort of homosexual men.

Methods: At the baseline visit in the Study for the Prevention of Anal Cancer (SPANC), all men completed a questionnaire and underwent anal swabbing for cytology and HPV genotyping, followed by high resolution anoscopy. Read More

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December 2016
24 Reads

Histological outcomes of anal high-grade cytopredictions.

Cancer Cytopathol 2018 Feb 20;126(2):136-144. Epub 2017 Oct 20.

Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Background: Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period.

Methods: The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old. Read More

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February 2018
4 Reads

Are Prophylactic Antibiotic Agents Indicated in Anorectal Surgery for Patients with Human Immunodeficiency Virus?

Surg Infect (Larchmt) 2017 Nov/Dec;18(8):924-928. Epub 2017 Oct 13.

2 Division of Colorectal Surgery, Drexel University College of Medicine , Philadelphia, Pennsylvania.

Background: With increased survival among patients with human immunodeficiency virus (HIV), surgeons have been seeing more cases of anal dysplasia and cancer. There is, however, no data on the incidence of surgical site infections (SSIs) in HIV-positive patients undergoing elective anorectal procedures, nor on the administration of prophylactic antibiotic agents. We reviewed a HIV-positive population that has undergone elective anorectal biopsy of areas of dysplasia observed on office anoscopy to assess the need for antibiotic prophylaxis. Read More

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June 2018
12 Reads

Risk factors for anal high-grade squamous intraepithelial lesions in HIV-positive MSM: is targeted screening possible?

AIDS 2017 10;31(16):2295-2301

aDepartment of Internal Medicine bDepartment of Dermatology, Academic Medical Center, University of Amsterdam cDepartment of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands.

Objective: HIV-positive MSM are at increased risk for developing anal squamous cell carcinoma. Detection of precursor lesions of anal cancer [anal high-grade squamous intraepithelial lesions (HSIL)] is cumbersome and expensive. Our objective was to identify potential risk factors for anal HSIL in HIV-positive MSM to develop more stringent screening criteria. Read More

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October 2017
26 Reads

Risk factors for infection by oncogenic human papillomaviruses in HIV-positive MSM patients in the ART era (2010-2016).

Medicine (Baltimore) 2017 Sep;96(39):e8109

aDepartment of Infectious Diseases bDepartment of Pathology, Virgen de las Nieves University Hospital, Granada cUnit of Infectious Diseases, "University Hospital Complex", Jaen, Spain.

Squamous cell carcinoma of anus (SCCA) is one of the most frequent non-AIDS-defining diseases in HIV patients, mainly in men who have sex with men (MSM), and it is associated with human papillomavirus (HPV) infection.To determine the prevalence of high-risk HPV (HR-HPV) genotypes, premalignant lesions (HSIL) and SCCA in a cohort of HIV-positive MSM; to study the distribution of HPV genotypes according to anal histology results; and to analyze risk factors for this infection.This prospective single-center study was conducted between May 2010 and September 2016. Read More

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September 2017
11 Reads

Incidence of Anal Dysplasia in a Population of High-Risk Women: Observations at a Cervical Pathology Unit.

J Low Genit Tract Dis 2017 Oct;21(4):329-335

1Cervical Pathology Unit, Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, Madrid, Spain; and 2Medical School at the Universidad Complutense de Madrid, Madrid, Spain.

Objectives: This study aimed to evaluate the incidence of anal dysplasia in women at high risk of developing those lesions and to assess the relationships between positive anal cytology and different risk factors.

Materials And Methods: We performed an observational cross-sectional study involving a patient survey and chart review. The study was conducted at the cervical pathology unit at the Hospital Universitario 12 de Octubre, Madrid, Spain, from 2011 to 2015. Read More

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October 2017
13 Reads

Management of precancerous anal intraepithelial lesions in human immunodeficiency virus-positive men who have sex with men: Clinical effectiveness and cost-effectiveness.

Cancer 2017 Dec 26;123(23):4709-4719. Epub 2017 Sep 26.

Massachusetts General Hospital Institute for Technology Assessment, Harvard Medical School, Boston, Massachusetts.

Background: Human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) are at disproportionately high risk for anal cancer. There is no definitive approach to the management of high-grade squamous intraepithelial lesions (HSIL), which are precursors of anal cancer, and evidence suggests that posttreatment adjuvant quadrivalent human papillomavirus (qHPV) vaccination improves HSIL treatment effectiveness. The objectives of this study were to evaluate the optimal HSIL management strategy with respect to clinical effectiveness and cost-effectiveness and to identify the optimal age for initiating HSIL management. Read More

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December 2017
22 Reads

The EVVA Cohort Study: Anal and Cervical Type-Specific Human Papillomavirus Prevalence, Persistence, and Cytologic Findings in Women Living With HIV.

J Infect Dis 2017 08;216(4):447-456

Chronic Viral Illness Service, McGill University Health Centre (MUHC).

Background: The risk of anal cancer due to high-risk human papillomavirus (HR-HPV) is higher in women living with human immunodeficiency virus (HIV) than in the general population. We present findings of cervical and anal HPV and cytologic tests at baseline in the EVVA cohort study and HPV persistence data 6 months after baseline.

Methods: Semiannual visits included questionnaires, chart reviews, cervical/anal cytologic and cervical/anal HPV testing for 2 years. Read More

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August 2017
93 Reads