32,057 results match your criteria Anorexia Nervosa


NEW INSIGHTS ON THE REGULATION OF CANCER CACHEXIA BY N-3 POLYUNSATURATED FATTY ACIDS.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Sao Paulo, Brazil,; Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil;. Electronic address:

Cancer cachexia is a multifactorial syndrome that develops during malignant tumor growth. Changes in plasma levels of several hormones and inflammatory factors result in an intense catabolic state, decreased activity of anabolic pathways, anorexia, and marked weight loss, leading to cachexia development and/or accentuation. Inflammatory mediators appear to be related to the control of a highly regulated process of muscle protein degradation that accelerates the process of cachexia. Read More

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December 2018
2 Reads

Aberrations in the female reproductive organs and a role of telocytes in a rat model of anorexia nervosa.

Folia Med Cracov 2018 ;58(3):115-125

Department of Pathophysiology, Jagiellonian University Medical College, Czysta 18, Kraków, Poland.

Background: Anorexia nervosa is a widely prevalent eating disorder that o en leads to life-threatening complications. Since it mostly concerns females, many authors have focused on studying the reproductive system in anorexic women. Recently discovered telocytes may give a new insight into the pathophysiology of gynecological complications in these patients. Read More

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January 2018
1 Read

Family-based treatment: Where are we and where should we be going to improve recovery in child and adolescent eating disorders.

Int J Eat Disord 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry and UCSF Weill Institute for Neurosciences, University of California, San Francisco, California.

Objective: Family therapy has long been advocated as an effective intervention for eating disorders. A specific form of family therapy, one that utilizes family resources, has proven especially effective for adolescents with anorexia or bulimia nervosa (AN and BN). First developed in London, a behaviorally focused adaptation, called family-based treatment (FBT), has been manualized and systematically studied in six randomized clinical trials for adolescent AN and two for adolescent BN. Read More

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December 2018
1 Read

Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa.

Mol Neurobiol 2018 Dec 5. Epub 2018 Dec 5.

Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

In MRI scans of patients with anorexia nervosa (AN), reductions in brain volume are often apparent. However, it is unknown whether such brain abnormalities are influenced by genetic determinants that partially overlap with those underlying AN. Here, we used a battery of methods (LD score regression, genetic risk scores, sign test, SNP effect concordance analysis, and Mendelian randomization) to investigate the genetic covariation between subcortical brain volumes and risk for AN based on summary measures retrieved from genome-wide association studies of regional brain volumes (ENIGMA consortium, n = 13,170) and genetic risk for AN (PGC-ED consortium, n = 14,477). Read More

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December 2018
1 Read

Vertebral fractures cascade: potential causes and risk factors.

Osteoporos Int 2018 Dec 5. Epub 2018 Dec 5.

Rheumatology Department, INSERM 1153, CHU Paris Cochin, Paris Descartes University, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France.

We performed a study to identify potential causes and risk factors of vertebral fracture cascade. Vertebral fracture cascade is a severe clinical event in patients with bone fragility. Only half of patients have an identified cause of secondary osteoporosis. Read More

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December 2018

Ghrelin serves as a signal of energy utilization and is involved in maintaining energy homeostasis in broilers.

Gen Comp Endocrinol 2018 Nov 30. Epub 2018 Nov 30.

College of Animal Science and Technology, Shandong Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, No. 61 Daizong Street, Taian, 271018, PR China. Electronic address:

Ghrelin, one of the most important appetite regulating peptides, is involved in the regulation of energy homeostasis. The anorexia effect of ghrelin in chickens is contrary to that of ghrelin in mammals. In the present study, the effects of feeding status and dietary energy level on plasma total ghrelin levels and expression were studied in broilers. Read More

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November 2018

Intracholecystic papillary-tubular neoplasm of the gallbladder originating in the cystic duct with extensive intraepithelial progress in the common bile duct.

Clin J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Department of Gastroenterology, Sendai City Medical Center, 5-22-1, Tsurugaya, Miyagino-ku, Sendai, Miyagi, Japan.

A 59-year-old man with anorexia who had a history of cholecystectomy was referred to our hospital. Imaging examinations revealed a contrast-enhanced tumor in the residual cystic duct and a part of the common bile duct. Endoscopic retrograde cholangiopancreatography and peroral-cholangioscopy showed a papillary tumor with movement and a change in the shape. Read More

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November 2018
1 Read

Clients.

Aust J Prim Health 2018 Dec 3. Epub 2018 Dec 3.

The therapeutic relationship plays a unique and pivotal role in the treatment and recovery of individuals with mental illness. The aim of the questionnaire was to understand clients' perceptions of the factors affecting the formation of the therapeutic relationship during treatment or recovery from self-reported anorexia nervosa. Former or current individuals diagnosed with anorexia nervosa, 18 years and over, were invited to participate in an online questionnaire developed by the researchers. Read More

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December 2018
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Asymmetric Insular Connectomics Revealed by Diffusion Magnetic Resonance Imaging Analysis of Healthy Brain Development.

Brain Connect 2018 Dec 1. Epub 2018 Dec 1.

Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States.

The insula has been implicated in playing important roles in various brain functions including consciousness, homeostasis, perception, self-awareness, language processing, and interpersonal experience. Abnormalities of the insula have been observed in patients suffering from addiction, deteriorating language function, anorexia, and emotional dysregulation. We analyzed typical development of insular connections in a large-scale pediatric population using 642 magnetic resonance imaging (MRI) examinations. Read More

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December 2018

Should we shed the weight criterion for anorexia nervosa?

Aust N Z J Psychiatry 2018 Dec 2:4867418814958. Epub 2018 Dec 2.

1 Centre for Mental Health, Swinburne University of Technology, Hawthorn, VIC, Australia.

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December 2018

When meta-analyses get it wrong: response to 'treatment outcomes for anorexia nervosa: a systematic review and meta-analysis of randomized controlled trials'.

Psychol Med 2018 Dec 5:1-2. Epub 2018 Dec 5.

Department of Psychiatry and Neurosciences,McMaster University,Hamilton, ON,Canada.

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December 2018
2 Reads

Complications somatiques de l’anorexie mentale. Elles sont responsables d’une mortalité élevée.

Rev Prat 2016 Feb;66(2):153-157

Clinique des maladies mentales et de l'encéphale, hôpital Sainte-Anne, Paris, France.

Medical complications of anorexia nervosa. Anorexia nervosa causes acute or chronic medical complications that can affect most organs: dermatologic complications, gastrointestinal complications (including constipation, delayed gastric emptying, rarely hepatitis), endocrine and bone (amenorrhea, infertility, hypoglycemia, delayed puberty, arrested growth, osteoporosis.. Read More

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February 2016
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Nouvelles approches de la prise en charge de l’anorexie mentale. Traiter ce trouble comme s’il était une forme d’addiction.

Rev Prat 2016 Feb;66(2):148-152

Clinique des maladies mentales et de l'encéphale, hôpital Sainte-Anne, Paris, France.

New therapeutic approaches in anorexia nervosa. Anorexia nervosa is characterized by nutritional, somatic and psychiatric symptoms that require multidisplinary approaches. New therapeutic approaches have the increase the quality of the alliance between the patient and the therapist, and therefore facilitate the commitment process (such as with to motivational therapy); these therapies also aim at facilitating mental flexibility, increase central coherence, elaborate new strategies to resolve problems (such as with cognitive remediation and mindfulness based cognitive therapy), and reinforcement of family ressources (during marriage and family therapy). Read More

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February 2016

Repérage précoce de l’anorexie mentale. Un dépistage simple peut prévenir chronicité et complications.

Authors:
Aurore Guy-Rubin

Rev Prat 2016 Feb;66(2):146-147

Clinique des maladies mentales et de l'encéphale, hôpital Sainte-Anne, Paris, France.

Early identification of anorexia nervosa. Early identification of anorexia nervosa is a public health issue. It would limit or prevent morbidity and mortality from this disorder that affects girls and young women in priority. Read More

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February 2016

Neurobiology of social reward valuation in adults with a history of anorexia nervosa.

PLoS One 2018 4;13(12):e0205085. Epub 2018 Dec 4.

Department of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America.

Objective: Anorexia nervosa (AN) is a disorder characterized by atypical patterns of reward valuation (e.g. positive valuation of hunger). Read More

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December 2018
2 Reads

Efficacy of Borrelia burgdorferi vaccine in dogs in North America: A systematic review and meta-analysis.

J Vet Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Research and Scholarship Team, McLaughlin Library, University of Guelph, Guelph, Ontario, Canada.

Background: Lyme borreliosis, a tick-borne disease, is endemic to some parts of North America and is an emerging disease in other parts of the world. Vaccination is an increasingly common, although controversial, method used in the prevention of Lyme disease in dogs; the reported efficacies of Borrelia burgdorferi vaccines in dogs are highly variable, ranging from 50% to 100%.

Objectives: To determine the efficacy of vaccines for prevention of Lyme disease in dogs in North America. Read More

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December 2018

Successful surgical resolution of a ceco-cecal intussusception in a 15-month-old Angus heifer.

Can Vet J 2018 Oct;59(10):1071-1074

Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849, USA.

A 15-month-old Angus heifer was presented for anorexia and abdominal discomfort. Transabdominal ultrasound was suggestive of a ceco-cecal intussusception. Exploratory laparotomy confirmed the diagnosis and a cecectomy was performed. Read More

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October 2018

Frequency and characteristics of drowsiness, somnolence, or daytime sleepiness in patients with advanced cancer.

Palliat Support Care 2018 Dec 4:1-5. Epub 2018 Dec 4.

Palliative Care and Rehabilitation Medicine,The University of Texas MD Anderson Cancer Center,Houston,TX.

IntroductionCancer-related drowsiness (CRD) is a distressing symptom in advanced cancer patients (ACP). The aim of this study was to determine the frequency and factors associated with severity of CRD. We also evaluated the screening performance of Edmonton Symptom Assessment Scale-drowsiness (ESAS-D) item against the Epworth Sedation Scale (ESS). Read More

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December 2018

STORE-gastrointestinal functions and gastrointestinal hormones in patients with liver failure.

Medicine (Baltimore) 2018 Nov;97(48):e13167

Department of Preventive Medicine, Medical College, Henan University of Science and Technology.

This study aims to investigate the gastrointestinal functions of patients with liver failure (LF) based on gastrointestinal dysfunction (GD) scores and serum gastrointestinal hormone levels.The GD in LF patients was scored using the gastrointestinal dysfunction scoring criteria. Serum gastrin (GAS), cholecystokinin (CCK), and motilin (MTL) levels were determined in LF patients. Read More

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November 2018

Subjective evaluation of outpatient treatment for adolescent patients with anorexia nervosa.

Eat Weight Disord 2018 Nov 29. Epub 2018 Nov 29.

Department of Clinical Psychology, Freie Universität Berlin, Berlin, Germany.

Background: The current study investigates determinants of treatment evaluation by adolescent outpatients with anorexia nervosa (AN) and the accordance with their parents' and psychotherapists' evaluation.

Sampling And Methods: The sample included 50 female adolescent outpatients (mean age: 16.9 ± 1. Read More

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November 2018
3 Reads

Having an Eating Disorder and Still Being Able to Flourish? Examination of Pathological Symptoms and Well-Being as Two Continua of Mental Health in a Clinical Sample.

Front Psychol 2018 15;9:2145. Epub 2018 Nov 15.

Psychology, Health, & Technology, Centre for eHealth and Wellbeing Research, University of Twente, Enschede, Netherlands.

Eating Disorders (EDs) are serious psychiatric disorders, impacting physical and psychosocial functioning, often with a chronic course and high mortality rates. The two continua model of mental health states that mental health is a complete state, that is, not merely the absence of mental illness, but also the presence of mental health. This model was studied among ED patients by examining the presence and correlates of well-being and psychopathology. Read More

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November 2018
1 Read

Waking up every day in a body that is not yours: a qualitative research inquiry into the intersection between eating disorders and pregnancy.

BMC Pregnancy Childbirth 2018 Nov 29;18(1):463. Epub 2018 Nov 29.

Department of Biostatistics, West Virginia University School of Public Health, Morgantown, WV, USA.

Background: Women with eating disorders are more likely to negatively react to finding out they are pregnant, although this difference in attitudes between women with eating disorders and controls disappears at 18-weeks' gestation. Those with anorexia also are twice as likely to have an unplanned pregnancy and those with bulimia have a 30-fold increased chance compared with healthy controls. Therefore, due to these considerations, pregnancy and the transition to motherhood can be an extremely challenging time for these women both psychologically and physically. Read More

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November 2018

Liquorice (Glycyrrhiza glabra): the journey of the sweet root from Mesopotamia to England.

Authors:
M R Lee

J R Coll Physicians Edinb 2018 Dec;48(4):378-382

112 Polwarth Terrace, Merchiston, Edinburgh EH11 1NN, UK.

Liquorice is a very ancient plant widely used in the East for millennia. It has often been employed in sweets and confectionery and also for minor ailments including cough, constipation and dyspepsia. It was probably carried to Europe by the Cluniac order of monks. Read More

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December 2018
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National population-based data on the incidence, prevalence, and psychiatric comorbidity of eating disorders in Taiwanese adolescents and young adults.

Int J Eat Disord 2018 Nov 28. Epub 2018 Nov 28.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Objective: Nationwide data on eating disorders (EDs) among East Asian populations are scarce. This study aimed to estimate the prevalence, incidence, and psychiatric comorbidities of EDs in Taiwan.

Method: Drawing from the National Health Research Institute database, we identified the study subjects aged 11-34 years who received an ED diagnosis during ambulatory visits or hospitalization from 2001 to 2012. Read More

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November 2018
5 Reads

Weight restoration in atypical anorexia nervosa: A clinical conundrum.

Int J Eat Disord 2018 Nov 28. Epub 2018 Nov 28.

Division of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, California.

The determination of the treatment goal weight for adolescents with a restrictive eating disorder (ED) and a prior history of obesity, such as in atypical anorexia nervosa (AAN), represents an ongoing challenge for clinicians. This determination is particularly complex given competing interests of physical recovery from significant weight loss, mental recovery from ED psychopathology, and the medical comorbidities associated with obesity. We report the case of a 15-year old female with a history of obesity and irregular periods who presented with significant weight loss and absence of menses for 3 months. Read More

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November 2018
1 Read

The role of self-esteem in the treatment of patients with anorexia nervosa - A systematic review and meta-analysis.

Int J Eat Disord 2018 Nov 28. Epub 2018 Nov 28.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Centre, Hamburg-Eppendorf & Schön Clinic Hamburg Eilbek, Hamburg, Germany.

Objective: We aimed to provide a comprehensive overview of the role of self-esteem in the treatment of patients with anorexia nervosa (AN). Specifically, our objectives were to investigate the differences in self-esteem between individuals with AN and healthy controls, or individuals with other eating disorders, and to examine self-esteem as an outcome, predictor, moderator, and mediator in AN treatment.

Method: The databases PsycINFO, PSYNDEXplus, Ovid MEDLINE®, and ProQuest were searched for studies published from 1990 to 2018. Read More

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November 2018

Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer.

World J Gastrointest Oncol 2018 Nov;10(11):421-430

Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul 03722, South Korea.

Aim: To directly compare the efficacy and toxicity of standard-dose FOLFIRINOX (sFOLFIRINOX) and modified-dose FOLFIRINOX (mFOLFIRINOX, 75% of standard-dose) for pancreatic cancer.

Methods: One hundred and thirty pancreatic cancer patients who received sFOLFIRINOX ( = 88) or mFOLFIRINOX ( = 42) as their first-line chemotherapy from January 2013 to July 2017 were retrospectively reviewed. For efficacy analysis, the objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) were evaluated and compared using Pearson's chi-square test, Kaplan-Meier plot and log-rank test. Read More

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November 2018

Social living simultaneously increases infection risk and decreases the cost of infection.

Proc Biol Sci 2018 Nov 28;285(1892). Epub 2018 Nov 28.

Odum School of Ecology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Elevated parasite infection risk is considered to be a near-universal cost of social living. However, living in groups may also provide benefits that reduce the negative impacts of infection. These potential 'tolerance' benefits of living socially are theoretically possible, but have rarely been described. Read More

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November 2018
1 Read

Phosphate binders, appetite and nutritional status in maintenance hemodialysis patients.

Asia Pac J Clin Nutr 2018 ;27(6):1207-1215

Nephrology Division, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine Tel Aviv University, Israel.

Background And Objectives: The potential side effects of common phosphate binders are gastrointestinal in practice. We hypothesized that regular use of phosphate binders may be associated with decreased appetite, dietary intake and consequently, poor nutritional status.

Methods And Study Design: This was cross-sectional study of 78 patients (mean age 67. Read More

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January 2018

Refeeding in anorexia nervosa.

Eur J Pediatr 2018 Nov 27. Epub 2018 Nov 27.

Assistance Publique-Hôpitaux de Paris, Service d'Endocrinologie Diabétologie Pédiatrique, Centre de Référence des Maladies Endocriniennes de la Croissance et du Développement, Hôpital Robert Debré, Paris, France.

Refeeding in anorexia nervosa is a collaborative enterprise involving multidisciplinary care plans, but clinicians currently lack guidance, as treatment guidelines are based largely on clinical confidence rather than more robust evidence. It seems crucial to identify reproducible approaches to refeeding that simultaneously maximize weight recovery and minimize the associated risks, in addition to improving long-term weight and cognitive and behavioral recovery and reducing relapse rates. We discuss here various approaches to refeeding, including, among others, where, by which route, how rapidly patients are best refed, and ways of choosing between them, taking into account the precautions or the potential effects of medication or of psychological care, to define better care plans for use in clinical practice. Read More

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November 2018

Hypothesis: Clues From Mammalian Hibernation for Treating Patients With Anorexia Nervosa.

Authors:
Barbara Scolnick

Front Psychol 2018 12;9:2159. Epub 2018 Nov 12.

Psychology and Brain Science, Boston University, Boston, MA, United States.

This hypothesis is that anorexia nervosa (AN) is a biologically driven disorder, and mammalian hibernation may offer clues to its pathogenesis. Using this approach, this hypothesis offers suggestions for employing heart rate variability as an early diagnostic test for AN; employing the ketogenic diet for refeeding patients, attending to omega 3:6 ratio of polyunsaturated fatty acids (PUFAs) in the refeeding diet; and exploring clinical trials of the endocannabinoid-like agent, palmitoylethanolamde for patients with AN. This hypothesis also explores the role of lipids and autoimmune phenomena in AN, and suggest a lipodomics study to search for antibodies in the serum on patients with AN. Read More

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November 2018
1 Read

Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials.

BMC Cancer 2018 Nov 27;18(1):1174. Epub 2018 Nov 27.

Department of Medicine, Division of Oncology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, 77030, USA.

Background: Cachexia is a multisystem syndrome characterized by weight loss, anorexia, loss of muscle mass, systemic inflammation, insulin resistance, and functional decline. Management of cachexia involves addressing multiple underlying biological mechanisms. Previous review on pharmacological management of cancer cachexia identified progestins and corticosteroids as effective agents for treatment of cachexia. Read More

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November 2018

Double standards in body evaluation? How identifying with a body stimulus influences ratings in women with anorexia nervosa and bulimia nervosa.

Int J Eat Disord 2018 Nov 27. Epub 2018 Nov 27.

Department of Clinical Psychology and Psychotherapy, Osnabrück University, Osnabrück, Germany.

Objective: Women with eating disorders (ED) evaluate their own body more negatively than do women without ED. However, it is unclear whether this negative rating is due to objective bodily features or different standards for one's own body and others' bodies. Therefore, the purpose of this study was to examine whether women with ED apply double standards when rating bodies by disentangling the objective features of one's own body from the feelings of ownership. Read More

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November 2018
1 Read

Recurrent hyponatremia in a young adult woman with anorexia nervosa and the effects of insufficient communication.

Int J Eat Disord 2018 Nov 27. Epub 2018 Nov 27.

Department of Pediatrics, Division of Adolescent Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

This is the case of an 18-year-old young adult woman with anorexia nervosa (AN) who presented to the emergency department with complications from AN and was found to be hyponatremic. The hyponatremia was prioritized and corrected with fluids on hospital day one. The consulting adolescent medicine team recommended the primary inpatient medical team initiate the malnutrition protocol. Read More

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November 2018
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A Possibility of Simultaneous Treatment with the Multicomponent Drug, Ninjin'yoeito, for Anorexia, Apathy, and Cognitive Dysfunction in Frail Alzheimer's Disease Patients: An Open-Label Pilot Study.

J Alzheimers Dis Rep 2017 Dec 9;1(1):229-235. Epub 2017 Dec 9.

Uchida Hospital, Numata, Gunma, Japan.

A recent classification analysis of neuropsychiatric symptoms in patients with Alzheimer's disease (AD) revealed a distinct cluster with apathy and eating problems including anorexia that exhibits frailty. The apathy and frailty are risk factors in the disease progresses. However, there is currently no effective drug for treating both anorexia and apathy in AD. Read More

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December 2017
4 Reads

Latin American countries lead in Google search volumes for anorexia nervosa and bulimia nervosa: Implications for global mental health research.

Authors:
Karin Eli

Int J Eat Disord 2018 Nov 26. Epub 2018 Nov 26.

Institute of Social and Cultural Anthropology, University of Oxford, Oxford, United Kingdom.

Objective: Although eating disorders occur worldwide, prevalence data beyond Euro-American contexts are sparse, and eating disorders largely remain outside global mental health agendas. This study aims to address this gap in the epidemiological literature through a global infodemiological comparison of Google search volumes for the topics "Anorexia nervosa" and "Bulimia nervosa."

Method: Data were generated through Google Trends, a tool that assesses the relative search volumes of keywords and topics. Read More

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November 2018
3 Reads

Compensatory gastric stretching following subtotal gastric resection due to gastric adenocarcinoma in a diamond python (Morelia spilota spilota).

Aust Vet J 2018 Dec;96(12):481-486

Avian Reptile and Exotic Pet Hospital, School of Veterinary Science, University of Sydney, Camden, 2570, New South Wales, Australia.

Case Report: A 7-year-old male diamond python (Morelia spilota spilota) presented with a 2-month history of anorexia and a discrete intracoelomic mass, approximately 15 cm in length, located 90 cm from the head and approximately two-thirds of the snout to vent length. Physical examination determined the mass was likely to be stomach, testes or the right kidney. Radiographs showed a soft tissue opacity mass in the region of the stomach; fine needle aspirate demonstrated cellular debris admixed with bacteria and degenerate heterophils. Read More

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December 2018

Associations between Theileria orientalis Ikeda type infection and the growth rates and haematocrit of suckled beef calves in the North Island of New Zealand.

N Z Vet J 2018 Nov 26:1-19. Epub 2018 Nov 26.

a School of Veterinary Science , Massey University , Private Bag 11222, Palmerston North 4442 , New Zealand.

Aim: The principle aim of this study was to examine the association between infection with Theileria orientalis Ikeda type and growth rates of suckled beef calves on four beef farms. In addition, associations between calf sex, sampling time, and individual farm and T. orientalis Ikeda type infection intensity and haematocrit (HCT) were investigated. Read More

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November 2018
3 Reads

Morphological and functional impairment in the gut in a partial body irradiation minipig model of GI-ARS.

Int J Radiat Biol 2018 Nov 26:1-52. Epub 2018 Nov 26.

a Radiation countermeasure program, Scientific Research Department , Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences , Bethesda , USA ;

Purpose: Göttingen minipig (G-MP) displays classic gastrointestinal acute radiation syndrome (GI-ARS) following total body irradiation (TBI) at GI doses which are lethal by 10-14 days. In collaboration with BARDA, we are developing a hemi-body/partial body irradiation (PBI) model by exposing only the abdomen and lower extremities to study GI structure/function impairment, natural history of injury and recovery, as well as correlative biomarkers out to 30 days.

Materials And Methods: Twenty-four G-MP were exposed to either 12 or 16 Gy (LINAC Elekta); head, forelimbs, and thorax were outside the irradiation field, sparing ∼50% of the bone marrow. Read More

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November 2018
10 Reads

Usefulness of cell-free and concentrated ascites reinfusion therapy in the therapeutic management of advanced ovarian cancer patients with massive ascites.

Int J Clin Oncol 2018 Nov 24. Epub 2018 Nov 24.

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: The management of refractory ascites in advanced ovarian cancer (AOC) is vital for patients with abdominal distention, respiratory distress, and anorexia due to massive ascites with cancer peritonitis. We analyzed the benefits of concentrated ascites reinfusion therapy (CART) in the management of AOC.

Methods: We reviewed records of AOC patients who underwent CART between January 2011 and March 2017. Read More

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November 2018
2 Reads

SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy.

Sarcoma 2018 24;2018:2068517. Epub 2018 Oct 24.

MD Anderson Cancer Center, Sarcoma Medical Oncology, 1400 Holcombe Blvd, Unit 450, Houston, TX 77030, USA.

Histone deacetylase inhibitors (HDACi) can reverse chemoresistance, enhance chemotherapy-induced cytotoxicity, and reduce sarcoma proliferation in cell lines and animal models. We sought to determine the safety and toxicity of mocetinostat and its ability to reverse chemoresistance when administered with gemcitabine in patients with metastatic leiomyosarcoma resistant to prior gemcitabine-containing therapy. Participants with metastatic leiomyosarcoma received mocetinostat orally, 70 mg per day, three days per week, increasing to 90 mg after three weeks if well tolerated. Read More

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October 2018
2 Reads

Crazy'App: A web survey on representations and attitudes toward mental disorders using video testimonies.

Encephale 2018 Nov 20. Epub 2018 Nov 20.

Cermes3 - Centre de recherche médecine, sciences, santé, santé mentale et société, université Paris Descartes, 7, rue Guy-Môquet, BP 8, 94801 Villejuif cedex, France.

In the international context of efforts to combat the stigmatization of people with mental health problems, representations and attitudes about these illnesses have not to date been widely investigated in France. However, new technologies offer an unprecedented opportunity to collect such information on a large scale and to deploy more efficient action against stigma.

Objectives: The Crazy'App survey was designed as an instrument for studying potentially stigmatizing representations and attitudes towards mental disorders. Read More

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November 2018
1 Read

Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis.

Viruses 2018 Nov 21;10(11). Epub 2018 Nov 21.

United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.

Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MARV/Ang. In this retrospective study, we used data pooled from eight separate studies in nonhuman primates experimentally exposed with either 1000 pfu intramuscular (IM) MARV/Ang or MARV/MtE-Mus between 2012 and 2017 at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). Read More

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November 2018
2 Reads

A longitudinal study on the association between facets of mindfulness and eating disorder symptoms in individuals diagnosed with eating disorders.

Eur Eat Disord Rev 2018 Nov 22. Epub 2018 Nov 22.

Department of Psychological and Brain Sciences, University of Louisville, Louisville, Kentucky, USA.

Mindfulness-based treatments for eating disorders could be improved by understanding how facets of mindfulness predict eating disorder symptoms over time. We examined whether facets of mindfulness predict eating disorder symptoms over time and vice versa. Individuals with an eating disorder diagnosis (N = 124; 87. Read More

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November 2018
4 Reads

A systematic review and meta-analysis of gastrointestinal events associated with nonoperative therapies for neuroendocrine tumors.

Onco Targets Ther 2018 31;11:7655-7668. Epub 2018 Oct 31.

Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China,

The risk of gastrointestinal (GI) events induced by nonoperative therapies in patients with neuroendocrine tumors (NETs) is unclear. Nonoperative therapies include somatostatin analogs, molecular targeted agents, cytotoxic chemotherapy, interferon-α, and peptide receptor radionuclide therapy. We undertook an up-to-date meta-analysis to determine the incidence and relative risks (RRs) of GI events in NET patients treated with these therapies. Read More

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October 2018
3 Reads

Neuromodulation in eating disorders and obesity: a promising way of treatment?

Neuropsychiatr Dis Treat 2018 26;14:2817-2835. Epub 2018 Oct 26.

Department of Neurosurgery, Mutua de Accidentes de Zaragoza (Servicio de Neurocirugía), Zaragoza, Spain.

Neuromodulation can affect the functioning of the central nervous system (CNS), and emotional/eating behavior is an exciting facet of that functioning. Therefore, it would be possible to offer an alternative (or complement) treatment to psychotropic medications and different psychological and nutritional approaches to both eating disorders (EDs) and obesity. Although there are a number of publications in these areas, a systematic review has not been conducted to date. Read More

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October 2018
4 Reads

Inter-tissue communication in cancer cachexia.

Nat Rev Endocrinol 2018 Nov 21. Epub 2018 Nov 21.

Cancer Research Group, Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.

Cachexia is a systemic condition that occurs during many neoplastic diseases, such as cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by adipose tissue wasting and systemic inflammation. Cancer cachexia is often associated with anorexia and increased energy expenditure. Read More

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November 2018
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Listeriosis in fattening pigs caused by poor quality silage - a case report.

BMC Vet Res 2018 Nov 21;14(1):362. Epub 2018 Nov 21.

University Clinic for Swine, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine, Vienna, Austria.

Background: Listeria (L.) monocytogenes as the causative agent of listeriosis in humans and different animal species, has its reservoir in the environment. It can be found in the gut and faeces of healthy pigs, but under certain circumstances it may cause clinical disease. Read More

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November 2018
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