Annu Rev Microbiol 2018 Jun 15. Epub 2018 Jun 15.
Center for Biomolecular Sciences, University of Illinois, Chicago, Illinois 60607, USA; email: ,
The ribosome is a major antibiotic target. Many types of inhibitors can stop cells from growing by binding at functional centers of the ribosome and interfering with its ability to synthesize proteins. These antibiotics were usually viewed as general protein synthesis inhibitors, which indiscriminately stop translation at every codon of every mRNA, preventing the ribosome from making any protein. Read More