281 results match your criteria Annual Review of Chemical and Biomolecular Engineering[Journal]


Hydrogen Production and Its Applications to Mobility.

Annu Rev Chem Biomol Eng 2022 Apr 13. Epub 2022 Apr 13.

The Sargent Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, London, United Kingdom; email:

Hydrogen has been identified as one of the key elements to bolster longer-term climate neutrality and strategic autonomy for several major countries. Multiple road maps emphasize the need to accelerate deployment across its supply chain and utilization. Being one of the major contributors to global CO emissions, the transportation sector finds in hydrogen an appealing alternative to reach sustainable development through either its direct use in fuel cells or further transformation to sustainable fuels. Read More

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Zeolitic Imidazolate Framework Membranes: Novel Synthesis Methods and Progress Toward Industrial Use.

Annu Rev Chem Biomol Eng 2022 Apr 13. Epub 2022 Apr 13.

Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, USA; email:

In the last decade, zeolitic imidazolate frameworks (ZIFs) have been studied extensively for their potential as selective separation membranes. In this review, we highlight unique structural properties of ZIFs that allow them to achieve certain important separations, like that of propylene from propane, and summarize the state of the art in ZIF thin-film deposition on porous substrates and their modification by postsynthesis treatments. We also review the reported membrane performance for representative membrane synthesis approaches and attempt to rank the synthesis methods with respect to potential for scalability. Read More

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Medical 3D Printing: Tools and Techniques, Today and Tomorrow.

Annu Rev Chem Biomol Eng 2022 Apr 6. Epub 2022 Apr 6.

Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, North Carolina, USA; email:

Three-dimensional printing is a still-emerging technology with high impact for the medical community, particularly in the development of tissues for the clinic. Many types of printers are under development, including extrusion, droplet, melt, and light-curing technologies. Herein we discuss the various types of 3D printers and their strengths and weaknesses concerning tissue engineering. Read More

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Lessons from Biomass Valorization for Improving Plastic-Recycling Enzymes.

Annu Rev Chem Biomol Eng 2022 Apr 4. Epub 2022 Apr 4.

Laboratoire Gulliver (UMR 7083), CNRS, ESPCI Paris, PSL Research University, Paris, France; email:

Synthetic polymers such as plastics exhibit numerous advantageous properties that have made them essential components of our daily lives, with plastic production doubling every 15 years. The relatively low cost of petroleum-based polymers encourages their single use and overconsumption. Synthetic plastics are recalcitrant to biodegradation, and mismanagement of plastic waste leads to their accumulation in the ecosystem, resulting in a disastrous environmental footprint. Read More

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Multilevel Mesoscale Complexities in Mesoregimes: Challenges in Chemical and Biochemical Engineering.

Annu Rev Chem Biomol Eng 2022 Apr 4. Epub 2022 Apr 4.

State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, People's Republic of China; email:

This review discusses the complex behaviors in diverse chemical and biochemical systems to elucidate their commonalities and thus help develop a mesoscience methodology to address the complexities in even broader topics. This could possibly build a new scientific paradigm for different disciplines and could meanwhile provide effective tools to tackle the big challenges in various fields, thus paving a path toward combining the paradigm shift in science with the breakthrough in technique developments. Starting with our relatively fruitful understanding of chemical systems, the discussion focuses on the relatively pristine but very intriguing biochemical systems. Read More

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Blockchain Technology in the Chemical Industry.

Annu Rev Chem Biomol Eng 2022 Apr 1. Epub 2022 Apr 1.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom; email:

This article presents a review of the application of blockchain and blockchain-based smart contracts in the chemical and related industries. We introduce the basic concepts of blockchain and smart contracts and explain how some of their features are enabled. We review several typical or novel applications of blockchain and smart contract technologies and their enabling concepts and underlying technologies. Read More

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Technological Options for Direct Air Capture: A Comparative Process Engineering Review.

Annu Rev Chem Biomol Eng 2022 Apr 1. Epub 2022 Apr 1.

William A. Brookshire Department of Chemical & Biomolecular Engineering, University of Houston, Houston, Texas 77004, USA; email:

The direct capture of CO from ambient air presents a means of decelerating the growth of global atmospheric CO concentrations. Considerations relating to process engineering are the focus of this review and have received significantly less attention than those relating to the design of materials for direct air capture (DAC). We summarize minimum thermodynamic energy requirements, second law efficiencies, major unit operations and associated energy requirements, capital and operating expenses, and potential alternative process designs. Read More

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Nanotherapeutics and the Brain.

Annu Rev Chem Biomol Eng 2022 Feb 23. Epub 2022 Feb 23.

Department of Chemical Engineering, University of Washington, Seattle, Washington, USA; email:

Brain disease remains a significant health, social, and economic burden with a high failure rate of translation of therapeutics to the clinic. Nanotherapeutics have represented a promising area of technology investment to improve drug bioavailability and delivery to the brain, with several successes for nanotherapeutic use for central nervous system disease that are currently in the clinic. However, renewed and continued research on the treatment of neurological disorders is critically needed. Read More

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February 2022

Machine Learning for the Discovery, Design, and Engineering of Materials.

Annu Rev Chem Biomol Eng 2022 Feb 23. Epub 2022 Feb 23.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; email:

Machine learning (ML) has become a part of the fabric of high-throughput screening and computational discovery of materials. Despite its increasingly central role, challenges remain in fully realizing the promise of ML. This is especially true for the practical acceleration of the engineering of robust materials and the development of design strategies that surpass trial and error or high-throughput screening alone. Read More

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February 2022

The Critical Role of Process Analysis in Chemical Recycling and Upcycling of Waste Plastics.

Annu Rev Chem Biomol Eng 2022 Feb 23. Epub 2022 Feb 23.

BOTTLE Consortium, Golden, Colorado, USA; email:

There is an urgent need for new technologies to enable circularity for synthetic polymers, spurred by the accumulation of waste plastics in landfills and the environment and the contributions of plastics manufacturing to climate change. Chemical recycling is a promising means to convert waste plastics into molecular intermediates that can be remanufactured into new products. Given the growing interest in the development of new chemical recycling approaches, it is critical to evaluate the economics, energy use, greenhouse gas emissions, and other life cycle inventory metrics for emerging processes, relative to the incumbent, linear manufacturing practices employed today. Read More

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February 2022

Optogenetics Illuminates Applications in Microbial Engineering.

Annu Rev Chem Biomol Eng 2022 Feb 23. Epub 2022 Feb 23.

Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA; email:

Optogenetics has been used in a variety of microbial engineering applications, such as chemical and protein production, studies of cell physiology, and engineered microbe-host interactions. These diverse applications benefit from the precise spatiotemporal control that light affords, as well as its tunability, reversibility, and orthogonality. This combination of unique capabilities has enabled a surge of studies in recent years investigating complex biological systems with completely new approaches. Read More

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February 2022

Advances in Manufacturing Cardiomyocytes from Human Pluripotent Stem Cells.

Annu Rev Chem Biomol Eng 2022 Feb 23. Epub 2022 Feb 23.

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA; email:

The emergence of human pluripotent stem cell (hPSC) technology over the past two decades has provided a source of normal and diseased human cells for a wide variety of in vitro and in vivo applications. Notably, hPSC-derived cardiomyocytes (hPSC-CMs) are widely used to model human heart development and disease and are in clinical trials for treating heart disease. The success of hPSC-CMs in these applications requires robust, scalable approaches to manufacture large numbers of safe and potent cells. Read More

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February 2022

Direct Air Capture of CO Using Solvents.

Authors:
Radu Custelcean

Annu Rev Chem Biomol Eng 2022 Feb 18. Epub 2022 Feb 18.

Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA; email:

Large-scale deployment of negative emissions technologies (NETs) that permanently remove CO from the atmosphere is now considered essential for limiting the global temperature increase to less than 2°C by the end of this century. One promising NET is direct air capture (DAC), a technology that employs engineered chemical processes to remove atmospheric carbon dioxide, potentially at the scale of billions of metric tons per year. This review highlights one of the two main approaches to DAC based on aqueous solvents. Read More

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February 2022

Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions.

Annu Rev Chem Biomol Eng 2022 Feb 17. Epub 2022 Feb 17.

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, USA; email:

This review describes key milestones related to the production of biopharmaceuticals-therapies manufactured using recombinant DNA technology. The market for biopharmaceuticals has grown significantly since the first biopharmaceutical approval in 1982, and the scientific maturity of the technologies used in their manufacturing processes has grown concomitantly. Early processes relied on established unit operations, with research focused on process scale-up and improved culture productivity. Read More

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February 2022

Airborne Transmission of SARS-CoV-2: Evidence and Implications for Engineering Controls.

Authors:
V Faye McNeill

Annu Rev Chem Biomol Eng 2022 Feb 17. Epub 2022 Feb 17.

Department of Chemical Engineering and Department of Earth and Environmental Sciences, Columbia University, New York, NY, USA; email:

Since late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, causing a pandemic (coronavirus disease 2019, or COVID-19) with dire consequences, including widespread death, long-term illness, and societal and economic disruption. Although initially uncertain, evidence is now overwhelming that SARS-CoV-2 is transmitted primarily through small respiratory droplets and aerosols emitted by infected individuals. As a result, many effective nonpharmaceutical interventions for slowing virus transmission operate by blocking, filtering, or diluting respiratory aerosol, particularly in indoor environments. Read More

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February 2022

Interferometric Probing of Physical and Chemical Properties of Solutions: Noncontact Investigation of Liquids.

Annu Rev Chem Biomol Eng 2022 Feb 17. Epub 2022 Feb 17.

Process Systems Engineering, Technical University of Munich, Freising, Germany; email:

Interferometry is a highly versatile tool for probing physical and chemical phenomena. In addition to the benefit of noncontact investigations, even spatially resolved information can be obtained by choosing a suitable setup. This review presents the evolution of the various setups that have evolved since the first interferometers were developed in the mid-nineteenth century and highlights the benefits, limitations, and typical areas of application. Read More

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February 2022

Machine Learning-Assisted Design of Material Properties.

Annu Rev Chem Biomol Eng 2022 Feb 17. Epub 2022 Feb 17.

McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA; email:

Designing functional materials requires a deep search through multidimensional spaces for system parameters that yield desirable material properties. For cases where conventional parameter sweeps or trial-and-error sampling are impractical, inverse methods that frame design as a constrained optimization problem present an attractive alternative. However, even efficient algorithms require time- and resource-intensive characterization of material properties many times during optimization, imposing a design bottleneck. Read More

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February 2022

Flow Chemistry: A Sustainable Voyage Through the Chemical Universe en Route to Smart Manufacturing.

Annu Rev Chem Biomol Eng 2022 Feb 8. Epub 2022 Feb 8.

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA; email:

Microfluidic devices and systems have entered many areas of chemical engineering, and the rate of their adoption is only increasing. As we approach and adapt to the critical global challenges we face in the near future, it is important to consider the capabilities of flow chemistry and its applications in next-generation technologies for sustainability, energy production, and tailor-made specialty chemicals. We present the introduction of microfluidics into the fundamental unit operations of chemical engineering. Read More

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February 2022

Biosynthesis of Isonitrile- and Alkyne-Containing Natural Products.

Annu Rev Chem Biomol Eng 2022 Feb 2. Epub 2022 Feb 2.

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California, USA; email:

Natural products are a diverse class of biologically produced compounds that participate in fundamental biological processes such as cell signaling, nutrient acquisition, and interference competition. Unique triple-bond functionalities like isonitriles and alkynes often drive bioactivity and may serve as indicators of novel chemical logic and enzymatic machinery. Yet, the biosynthetic underpinnings of these groups remain only partially understood, constraining the opportunity to rationally engineer biomolecules with these functionalities for applications in pharmaceuticals, bioorthogonal chemistry, and other value-added chemical processes. Read More

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February 2022

Data-Driven Design and Autonomous Experimentation in Soft and Biological Materials Engineering.

Annu Rev Chem Biomol Eng 2022 Feb 2. Epub 2022 Feb 2.

Mechanical Engineering, Boston University, Boston, Massachusetts 02215, USA; email:

This article reviews recent developments in the applications of machine learning, data-driven modeling, transfer learning, and autonomous experimentation for the discovery, design, and optimization of soft and biological materials. The design and engineering of molecules and molecular systems have long been a preoccupation of chemical and biomolecular engineers using a variety of computational and experimental techniques. Increasingly, researchers have looked to emerging and established tools in artificial intelligence and machine learning to integrate with established approaches in chemical science to realize powerful, efficient, and in some cases autonomous platforms for molecular discovery, materials engineering, and process optimization. Read More

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February 2022

Wearable and Implantable Soft Bioelectronics: Device Designs and Material Strategies.

Annu Rev Chem Biomol Eng 2021 06;12:359-391

Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Republic of Korea; email:

High-performance wearable and implantable devices capable of recording physiological signals and delivering appropriate therapeutics in real time are playing a pivotal role in revolutionizing personalized healthcare. However, the mechanical and biochemical mismatches between rigid, inorganic devices and soft, organic human tissues cause significant trouble, including skin irritation, tissue damage, compromised signal-to-noise ratios, and limited service time. As a result, profuse research efforts have been devoted to overcoming these issues by using flexible and stretchable device designs and soft materials. Read More

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Bottom-Up Synthesis of Artificial Cells: Recent Highlights and Future Challenges.

Annu Rev Chem Biomol Eng 2021 06;12:287-308

Process Systems Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany; email:

The bottom-up approach in synthetic biology aims to create molecular ensembles that reproduce the organization and functions of living organisms and strives to integrate them in a modular and hierarchical fashion toward the basic unit of life-the cell-and beyond. This young field stands on the shoulders of fundamental research in molecular biology and biochemistry, next to synthetic chemistry, and, augmented by an engineering framework, has seen tremendous progress in recent years thanks to multiple technological and scientific advancements. In this timely review of the research over the past decade, we focus on three essential features of living cells: the ability to self-reproduce via recursive cycles of growth and division, the harnessing of energy to drive cellular processes, and the assembly of metabolic pathways. Read More

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Small-Scale Phenomena in Reactive Bubbly Flows: Experiments, Numerical Modeling, and Applications.

Annu Rev Chem Biomol Eng 2021 06;12:625-643

Mathematical Modeling and Analysis, Department of Mathematics, Technical University of Darmstadt, 64287 Darmstadt, Germany; email:

Improving the yield and selectivity of chemical reactions is one of the challenging tasks in paving the way for a more sustainable and climate-friendly economy. For the industrially highly relevant gas-liquid reactions, this can be achieved by tailoring the timescales of mixing to the requirements of the reaction. Although this has long been known for idealized reactors and time- and space-averaged processes, considerable progress has been made recently on the influence of local mixing processes. Read More

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Polymer-Infiltrated Nanoparticle Films Using Capillarity-Based Techniques: Toward Multifunctional Coatings and Membranes.

Annu Rev Chem Biomol Eng 2021 06;12:411-437

Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email:

Polymer-infiltrated nanoparticle films (PINFs) are a new class of nanocomposites that offer synergistic properties and functionality derived from unusually high fractions of nanomaterials. Recently, two versatile techniques,capillary rise infiltration (CaRI) and solvent-driven infiltration of polymer (SIP), have been introduced that exploit capillary forces in films of densely packed nanoparticles. In CaRI, a highly loaded PINF is produced by thermally induced wicking of polymer melt into the nanoparticle packing pores. Read More

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Infochemistry and the Future of Chemical Information Processing.

Annu Rev Chem Biomol Eng 2021 06 28;12:63-95. Epub 2021 Apr 28.

Infochemistry Scientific Center of ITMO University, 191002 Saint Petersburg, Russia; email:

Nowadays, information processing is based on semiconductor (e.g., silicon) devices. Read More

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RNA Engineering for Public Health: Innovations in RNA-Based Diagnostics and Therapeutics.

Annu Rev Chem Biomol Eng 2021 06 26;12:263-286. Epub 2021 Apr 26.

Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA; email:

RNA is essential for cellular function: From sensing intra- and extracellular signals to controlling gene expression, RNA mediates a diverse and expansive list of molecular processes. A long-standing goal of synthetic biology has been to develop RNA engineering principles that can be used to harness and reprogram these RNA-mediated processes to engineer biological systems to solve pressing global challenges. Recent advances in the field of RNA engineering are bringing this to fruition, enabling the creation of RNA-based tools to combat some of the most urgent public health crises. Read More

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Storage of Carbon Dioxide in Saline Aquifers: Physicochemical Processes, Key Constraints, and Scale-Up Potential.

Annu Rev Chem Biomol Eng 2021 06 19;12:471-494. Epub 2021 Apr 19.

Equinor Research Center, 7053 Trondheim, Norway; email:

CO storage in saline aquifers offers a realistic means of achieving globally significant reductions in greenhouse gas emissions at the scale of billions of tonnes per year. We review insights into the processes involved using well-documented industrial-scale projects, supported by a range of laboratory analyses, field studies, and flow simulations. The main topics we address are () the significant physicochemical processes, () the factors limiting CO storage capacity, and () the requirements for global scale-up. Read More

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Stepping on the Gas to a Circular Economy: Accelerating Development of Carbon-Negative Chemical Production from Gas Fermentation.

Annu Rev Chem Biomol Eng 2021 06 19;12:439-470. Epub 2021 Apr 19.

LanzaTech Inc., Skokie, Illinois 60077, USA; email:

Owing to rising levels of greenhouse gases in our atmosphere and oceans, climate change poses significant environmental, economic, and social challenges globally. Technologies that enable carbon capture and conversion of greenhouse gases into useful products will help mitigate climate change by enabling a new circular carbon economy. Gas fermentation usingcarbon-fixing microorganisms offers an economically viable and scalable solution with unique feedstock and product flexibility that has been commercialized recently. Read More

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Emerging Biomedical Applications Based on the Response of Magnetic Nanoparticles to Time-Varying Magnetic Fields.

Annu Rev Chem Biomol Eng 2021 06 15;12:163-185. Epub 2021 Apr 15.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA; email:

Magnetic nanoparticles are of interest for biomedical applications because of their biocompatibility, tunable surface chemistry, and actuation using applied magnetic fields. Magnetic nanoparticles respond to time-varying magnetic fields via physical particle rotation or internal dipole reorientation, which can result in signal generation or conversion of magnetic energy to heat. This dynamic magnetization response enables their use as tracers in magnetic particle imaging (MPI), an emerging biomedical imaging modality in which signal is quantitative of tracer mass and there is no tissue background signal or signal attenuation. Read More

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