144,748 results match your criteria Annual Review of Cell and Developmental Biology [Journal]
Addiction 2018 Dec 15. Epub 2018 Dec 15.
Laboratory for Studies in Economic Sociology, National Research University Higher School of Economics, 11 Myasnitskaya, Moscow, 101000, Russian Federation.
Background and aims Young Russians have been drinking less alcohol, and less strong spirits in particular, in recent years. This study aimed to disentangle age, period and birth cohort effects for the first time in Russia to improve our understanding of these trends. Design Age, period and cohort analysis of annual nationally representative repeated cross-sectional surveys (RLMS-HSE) using separate logistic models for each gender. Read More
Clin Exp Ophthalmol 2018 Dec 15. Epub 2018 Dec 15.
The Wilmer Eye Institute, Johns Hopkins University School of Medicine, USA.
Importance: It is important to establish reliable outcome measures to detect progression in retinitis pigmentosa (RP).
Background: To evaluate progression of RP using multimodal imaging, including spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) and microperimetry (MP).
Design: Retrospective longitudinal study at a tertiary teaching hospital. Read More
Eur J Trauma Emerg Surg 2018 Dec 14. Epub 2018 Dec 14.
Department for Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Armed Forces Hospital Ulm, HEMS "Christoph 22", Oberer Eselsberg 40, 89081, Ulm, Germany.
Background: The TraumaRegister DGU (TR-DGU) of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie, DGU) enables the participating hospitals to perform quality management. For that purpose, nine so-called audit filters have existed, since its foundation, which, inter alia, is listed in the Annual Report. The objective of this study effort is a revision of these quality indicators with the aim of developing pertinent new and reliable quality indicators for the management of severely injured patients. Read More
Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.
Hospital Clínic, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
The involvement of human papillomavirus (HPV) in laryngeal and hypopharyngeal lymphoepithelial carcinoma was investigated in a series of ten cases (seven laryngeal and three hypopharyngeal), retrieved from the files of three tertiary hospitals in the 2000-2017 period, through polymerase chain reaction with SPF10 primers and INNO-LiPA HPV Genotyping Extra II (Innogenetics). Epstein-Barr virus (EBV) was tested in all cases with in situ hybridization INFORM EBER Probe (Ventana Medical Systems). p16 and p53 expression were immunohistochemically analyzed. Read More
Lancet Public Health 2018 Dec 11. Epub 2018 Dec 11.
Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA. Electronic address:
Background: To inform plans to achieve universal health coverage (UHC), we estimated utilisation and unit cost of outpatient visits and inpatient admissions, did a decomposition analysis of utilisation, and estimated additional services and funds needed to meet a UHC standard for utilisation.
Methods: We collated 1175 country-years of outpatient data on utilisation from 130 countries and 2068 country-years of inpatient data from 128 countries. We did meta-regression analyses of annual visits and admissions per capita by sex, age, location, and year with DisMod-MR, a Bayesian meta-regression tool. Read More
Am J Cardiol 2018 Dec 3. Epub 2018 Dec 3.
Cardiology, Versilia Hospital, Lido di Camaiore, Italy.
The use of cardiac magnetic resonance (cMR) to assess remodeling and tissue characterization in primitive and secondary cardiomyopathies has progressively increased, and it carries important prognostic informations. The aim of this study was to assess the overall clinical value of cMR before implantable cardioverter defibrillator (ICD). All patients referred to our center for an ICD implantation and submitted to cMR (n = 134) were analyzed. Read More
Chudoku Kenkyu 2016 Sep;29(3):317-331
Chudoku Kenkyu 2016 Sep;29(3):279-311
Chudoku Kenkyu 2017 Mar;30(1):73-76
Chudoku Kenkyu 2017 Mar;30(1):66-72
Chudoku Kenkyu 2017 Mar;30(1):1-2
Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Background: The aim of this study was to examine work loss in patients with Crohn's disease.
Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015). Read More
Ann Bot 2018 Dec 14. Epub 2018 Dec 14.
Department of Physical Geography and Geoecology, Faculty of Science, Charles University, Prague, Czech Republic.
Background And Aims: The increasing frequency of disturbances in temperate forests is responsible for the greater numbers of trees with mechanically damaged cambial zones. Adjustment of wood anatomical structure to balance between safe and efficient water conductivity is one mechanism trees employ to cope with mechanical damage. The relative role of disturbances, tree age and climate in shaping xylem conduits and affecting xylem hydraulic conductivity remains unknown. Read More
Sci Total Environ 2018 Dec 5;657:558-567. Epub 2018 Dec 5.
Forschungsinstitut für Biologischen Landbau (FiBL), Department of International Cooperation, Ackerstrasse 113, Postfach 219, 5070 Frick, Switzerland.
Farmers expect yield reduction of cash crops like cocoa when growing in agroforestry systems compared to monocultures, due to competition for resources, e.g. nutrients and water. Read More
Sci Total Environ 2018 Nov 27;657:325-339. Epub 2018 Nov 27.
Key Laboratory of Water Cycle and Related Land Surface Processes, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.
Significant increases in vegetation cover on the Loess Plateau since the early 2000s have been well documented. However, the relevant hydrological effects are still unclear. Here, we investigated the changes in actual evapotranspiration (ET) from 2000 to 2016 and related them to climate change and vegetation greening in Yanhe River basin (YRB), a typical hilly-gully basin on the Loess Plateau, by using the remote-sensing based VIP model. Read More
Annu Rev Clin Psychol 2018 Dec 14. Epub 2018 Dec 14.
Department of Psychology, Stockholm University, SE-106 91 Stockholm, Sweden; email:
One-session treatment is a well-established evidence-based treatment for specific phobias in youths that incorporates reinforcement, cognitive challenges, participant modeling, psychoeducation, and skills training into a single, massed session of graduated exposure. This review begins by briefly examining the phenomenology, etiology, epidemiology, and assessment of specific phobias and then pivots to a description of One-Session Treatment. We examine the use of One-Session Treatment with children and adolescents, briefly discussing its components and application, and subsequently review almost two decades of research supporting its efficacy. Read More
Annu Rev Clin Psychol 2018 Dec 14. Epub 2018 Dec 14.
Department of Clinical, Neuro-, and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands; email:
Psychotherapies may work through techniques that are specific to each therapy or through factors that all therapies have in common. Proponents of the common factors model often point to meta-analyses of comparative outcome studies that show all therapies have comparable effects. However, not all meta-analyses support the common factors model; the included studies often have several methodological problems; and there are alternative explanations for finding comparable outcomes. Read More
Annu Rev Immunol 2018 Dec 14. Epub 2018 Dec 14.
Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands; email: ,
Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell-based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint blockade and adoptive T cell therapy as cancer immunotherapies. Read More
Int J Gynecol Pathol 2019 Jan;38(1):108-109
International Society of Gynecological Pathologists (J.T.R., C.B.G.), San Francisco, CA.
Anesthesiology 2019 Jan;130(1):171
Curr Med Res Opin 2018 Dec 14:1-16. Epub 2018 Dec 14.
e Global Health Economics, Amgen Inc. , Thousand Oaks , CA , USA.
Objective: Bone metastases are common among patients with advanced breast cancer, putting patients at increased risk of skeletal-related events (SREs). This study described impact of bone metastases, utilization of bone-targeted agents (BTAs) and physicians' decision processes for BTA use in advanced breast cancer.
Methods: Data were collected using the Adelphi Breast Cancer Disease-Specific Programme in the United States. Read More
Eur J Heart Fail 2018 Dec 13. Epub 2018 Dec 13.
National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Aims: We aimed to identify a 'frequent admitter' phenotype among patients admitted for acute decompensated heart failure (HF).
Methods And Results: We studied 10 363 patients in a population-based prospective HF registry (2008-2012), segregated into clusters based on their 3-year HF readmission frequency trajectories. Using receiver-operating characteristic analysis, we identified the index year readmission frequency threshold that most accurately predicts HF admission frequency clusters. Read More
Public Health Nurs 2018 Dec 13. Epub 2018 Dec 13.
School of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Objectives: This paper provides an overview of the status of dementia care in Mainland China under the framework of the three-tier long-term care system proposed by the Chinese government, and gives the direction for service development.
Methods: Official documents, annual reports of related associations, and studies conducted in Mainland China from 2006 to 2017, published both in English and Chinese were reviewed.
Results: With the establishment of the three-tier long-term care system, the Government has invested a lot in long-term care, and improvements have been made. Read More
J Anim Ecol 2018 Nov 22. Epub 2018 Nov 22.
School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, UK.
Pelagic and benthic systems usually interact, but their dynamics and production rates differ. Such differences influence the distribution, reproductive cycles, growth rates, stability and productivity of the consumers they support. Consumer preferences for, and dependence on, pelagic or benthic production are governed by the availability of these sources of production and consumer life history, distribution, habitat, behavioural ecology, ontogenetic stage and morphology. Read More
Geriatr Gerontol Int 2018 Dec;18(12):1651-1652
Hospital Director, National Center for Geriatrics and Gerontology, Obu, Japan.
J Am Geriatr Soc 2018 Dec 13. Epub 2018 Dec 13.
Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington.
Objective: To describe and compare two age groups' knowledge of medications linked to falls and willingness to change these medications to reduce their fall risk.
Method: We analyzed data from community-dwelling adults age 55 and older (n = 1812): 855 adults aged 55 to 64 years and 957 older adults (65 and older) who participated in the 2016 summer wave of the ConsumerStyles survey, an annual Web-based survey. The data are weighted to match the US Current Population Survey proportions on nine US Census Bureau demographic characteristics. Read More
Eur J Immunol 2018 Dec 12. Epub 2018 Dec 12.
Infectious Disease Research Institute, 1616 Eastlake Ave. E., Suite 400, Seattle, WA, 98102, USA.
Influenza A annually infects 5-10% of the world's human population resulting in one million deaths. Influenza causes annual epidemics and re-infects previously exposed individuals because of antigenic drift in the glycoprotein hemagglutinin. Due to antigenic drift, the immune system is simultaneously exposed to novel and conserved parts of the influenza virus via vaccination and/or infection throughout life. Read More
J Am Geriatr Soc 2018 Dec 12. Epub 2018 Dec 12.
Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington.
Objectives: To determine the prevalence and impact of common co-occurring symptoms among community-dwelling older adults in the United States.
Design: The National Health and Aging Trends Study is a nationally representative, prospective study with annual data collection between 2011 and 2017.
Setting: Community-based, in-person interviews (survey response rates, 71%-96%). Read More
ANZ J Surg 2018 Dec 11. Epub 2018 Dec 11.
Metro North Hospital and Health Service, Brisbane, Queensland, Australia.
Introduction: Injuries are a major cause of disability and lost productivity. The case for a national trauma registry has been recognized by the Australian Commission on Safety and Quality in Health Care and at a policy level.
Background: The need was flagged in 1993 by the Royal Australasian College of Surgeons and the Australasian Trauma Society. Read More
Pharmacoepidemiol Drug Saf 2018 Dec 12. Epub 2018 Dec 12.
Centre for Applied Research in Mental Health and Addiction, Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada.
Purpose: Opioid use and associated mortality and morbidity have substantially increased in Canada, which recent interventions have aimed to reduce. Tramadol is an atypical prescription-only (but unscheduled under Canada's narcotics law) opioid analgesic and not subject to controls for other (eg, strong) opioids. Given experiences in different jurisdictions, tramadol may have been increasingly dispensed as a "substitute" drug during a period with increasingly restrictive controls for other (scheduled) opioids. Read More
J Med Econ 2018 Dec 14:1-16. Epub 2018 Dec 14.
e College of Public Health , Zhengzhou University , Zhengzhou , China.
Objective: To construct a value-based healthcare system for rural Chinese hypertensive patients through increasing outpatient care reimbursement ratio.
Methods: This comparative study sampled two similar counties, Dangyang County and Zhijiang County, in Hubei Province of China, as the intervention group and the control group, respectively. The Social Health Insurance Fund of the intervention group budgeted 600 yuan per capita per year to insured patients with third stage hypertension to cover their outpatient expenditures, while the outpatient expenditures of the control group were not covered by its Social Health Insurance Fund. Read More
Primates 2000 Oct;41(4):393-405
Institute for Research in Reproduction (ICMR), Jehangir Merwanji Street, Parel, 400012, Mumbai, India.
Semen samples were collected from adult fertile bonnet monkeys twice a month by penile electroejaculation for twelve consecutive months. Various parameters like semen volume, weight of ejaculate and coagulum, sperm count, sperm motility, sperm morphology, and functional parameters e.g. Read More
J West Afr Coll Surg 2017 Jul-Sep;7(3):137-170
Health Phys 2013 Sep;105(3):236-244
The contribution of atmospheric discharged C to local C concentrations was investigated by analysis of C in environmental samples collected around the spent nuclear fuel reprocessing plant in Rokkasho, Aomori, Japan. From June 2006 to October 2011, the range of monthly averaged specific activities in atmospheric CO2 collected 2.6 km from the plant was 0. Read More
Methods Mol Biol 2019 ;1894:1-29
Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.
As a consequence of their increase in annual production and widespread distribution in the environment, nanoparticles potentially pose a significant public health risk. The sought-after catalytic activity granted by their physiochemical properties doubles as a hazard to physiological processes following exposure through inhalation, oral, transdermal, subcutaneous, and intravenous uptake. Upon uptake into the body, their size, morphology, surface charge, coating, and chemical composition augment the response of biological systems to the materials and enhance their toxicity. Read More
Indian J Pediatr 2018 Dec 13. Epub 2018 Dec 13.
Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India.
Objective: To study the incidence, clinical risk factors and outcome of thrombotic events in pediatric age group of 1 mo-12 y.
Methods: This prospective observational study was conducted in a tertiary care institute from September 2015 through October 2017. Forty nine children with thrombosis from 1 mo-12 y were enrolled. Read More
Mol Biol Rep 2018 Dec 13. Epub 2018 Dec 13.
Department of Marine Bio-Materials & Aquaculture, Pukyong National University, Busan, 48513, South Korea.
Insulin-like growth factor (IGF) expression plays a critical role in the endocrine regulation of proliferation, differentiation, and growth in shellfish as well as in fish. The Pacific oyster, Crassostrea gigas, is a significant aquaculture species that comprises a large percentage of the Korean shellfish industry; moreover, its growth is economically important in aquaculture. However, when measuring the growth rate in shellfish, the soft tissue weight is difficult to determine because of the shell weight. Read More
Matern Child Health J 2018 Dec 13. Epub 2018 Dec 13.
Division of Home Visiting and Early Childhood Systems, HRSA, Maternal and Child Health Bureau, 5600 Fishers Lane, Rockville, MD, 20857, USA.
Purpose Using a standardized approach and metrics to estimate home visiting costs across multiple evidence-based models and regions could improve the consistency and accuracy of cost estimates, allow stakeholders to observe trends in cost allocation, analyze how home visiting costs vary, and develop future program budgets. Between October 2015 and December 2018, we developed and pilot-tested the Home Visiting Budget Assistance Tool (HV-BAT) to standardize the collection of home visiting program costs and analyze costs for local implementing agencies (LIAs). Methods We recruited LIAs that implemented at least one of nine evidence-based home visiting models in 15 states implementing the Maternal, Infant, and Early Childhood Home Visiting (MIECHV) Program. Read More
J Spine Surg 2018 Sep;4(3):522-528
East Coast Orthopedics, Pompano, FL, USA.
Background: Due to increased postoperative complications with anterior cervical discectomy and fusion (ACDF), there has been an increasing interest in the use of cervical disc arthroplasty (CDA). Advancements in prosthetic designs and techniques have improved patient reported outcome measurements and minimized revision rates. There is a paucity in the literature regarding recent trends in CDA utilization and revision rates. Read More
Health Serv Res Manag Epidemiol 2018 Jan-Dec;5:2333392818795795. Epub 2018 Dec 3.
AP-OSI Research Unit, Alto Deba Integrated Healthcare Organisation, Mondragón, Spain.
Introduction: An integrated health and social care program for patients with heart failure (HF) was implemented at the Friuli-Venezia Giulia deployment site as part of the SmartCare European project. The objective of this study was to validate 2 different decision modeling techniques used to perform the economic evaluation.
Methods: Data were collected during the SmartCare project which enrolled 108 patients with HF and followed for more than 6 months. Read More
Digit Health 2018 Jan-Dec;4:2055207618816898. Epub 2018 Nov 29.
Department of Food and Nutrition, University of Helsinki, Helsinki, Finland.
Objective: To study the characteristics of large-scale loyalty card data obtained in Finland, and to evaluate their potential and challenges in health research.
Methods: We contacted the holders of a certain loyalty card living in a specific region in Finland via email, and requested their electronic informed consent to obtain their basic background characteristics and grocery expenditure data from 2016 for health research purposes. Non-participation and the characteristics and expenditure of the participants were mainly analysed using summary statistics and figures. Read More
J Ecol 2019 Jan 14;107(1):240-252. Epub 2018 Jun 14.
Departamento de Biología y Geología, Física y Química Inorgánica, Escuela Superior de Ciencias Experimentales y Tecnología, Universidad Rey Juan Carlos, C/ Tulipán s/n, 28933 Móstoles, Spain.
1. Biotic interactions are key determinants of plant community structure. Indirect interactions such as intransitivity ( in the absence of competitive hierarchies among species) have been hypothesized to benefit diversity within plant communities. Read More
Eye (Lond) 2018 Dec;32(12):1797-1799
In this issue, we acknowledge and thank the reviewers who have been active over the past year. We greatly appreciate their tireless and largely unseen work. It is thanks to them that the quality of papers continues to increase. Read More
Genet Med 2018 Dec 14. Epub 2018 Dec 14.
School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Purpose: There is little long-term, population-based data on uptake of prenatal diagnosis for Huntington disease (HD), a late-onset autosomal dominant neurodegenerative disorder, and the effect of the availability of preimplantation genetic diagnosis (PGD) on families' decisions about conventional prenatal diagnosis is not known. We report trends in prenatal diagnosis and preimplantation diagnosis for HD in the United Kingdom since services commenced.
Methods: Long-term UK-wide prospective case record-based service evaluation in 23 UK Regional Genetic Centres 1988-2015, and four UK PGD centers 2002-2015. Read More
J Am Soc Nephrol 2018 Dec 13. Epub 2018 Dec 13.
Division of Nephrology, Medizinische Klinik and Poliklinik IV, Klinikum der Universität München, Ludwig Maximilians University München, Munich, Germany
Background: In 2004, researchers reported that the number of nephrology clinical trials was low and that the reporting quality of such trials was suboptimal. Furthermore, the number or quality of preclinical kidney-related studies has not been systematically evaluated.
Methods: We performed a systematic review of randomized clinical trials published in 1966-2017 (listed in the Cochrane Library) and preclinical studies published in 1945-2017 (listed in PubMed). Read More
Thorax 2019 Jan;74(1):1-3
Host Defence Unit, Division of Respiratory Medicine, Royal Brompton Hospital, London, UK.
The new British Thoracic Society (BTS) Guideline for Bronchiectasis in Adults has been published. This article provides a summary of key highlights of the new BTS Guideline and covers who to investigate, what investigations should be carried out and a management strategy. Read More
BMJ 2018 Dec 13;363:k4983. Epub 2018 Dec 13.
VA Center for Clinical Management Research, Ann Arbor, Michigan, USA.
Objective: To investigate the credibility of claims that general practitioners lack time for shared decision making and preventive care.
Design: Monte Carlo microsimulation study.
Setting: Primary care, United States. Read More
Can J Diabetes 2018 Aug 16. Epub 2018 Aug 16.
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Electronic address:
Objectives: To describe insulin utilization and spending across Canada and investigate how interprovincial variations in long-acting insulin uptake impact provincial spending.
Methods: We conducted a cross-sectional time-series analysis of insulin products dispensed nationally from January 1, 2010, to December 31, 2015, using data from IQVIA (Durham, North Carolina, United States). Analysis was stratified according to insulin type, payer and province. Read More
Early Hum Dev 2018 Dec 10. Epub 2018 Dec 10.
Mater Dei Hospital, Malta. Electronic address:
Introduction: The requirement for medical services fluctuates. This study was carried out in order to attempt to extrapolate the service requirements for various cardiology services at Mater Dei Hospital, Malta over the coming five years, based on service demands from previous years.
Methods: Past annual data was obtained from hospital records for various services (to 2017). Read More
Nutr Metab Cardiovasc Dis 2018 Oct 16. Epub 2018 Oct 16.
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan; Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, 10581, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, 64057, Taiwan. Electronic address:
Background And Aim: Hyperuricemia (HUA) is associated with the prevalence of metabolic syndrome (MetS) and cardiovascular risks in various populations. HUA is also able to induce cardiomyocyte hypertrophy in mouse models. However, the dose-response effects of serum uric acid (SUA) on the prevalence of MetS and electrocardiographic left ventricular hypertrophy (LVH) are unclear. Read More