- Daniel P Kiehart,
- Janice M Crawford,
- Andreas Aristotelous,
- Stephanos Venakides,
- Glenn S Edwards
Annu Rev Cell Dev Biol 2017 10;33:169-202
Physics Department, Duke University, Durham, North Carolina 27708.
Dorsal closure is a key process during Drosophila morphogenesis that models cell sheet movements in chordates, including neural tube closure, palate formation, and wound healing. Closure occurs midway through embryogenesis and entails circumferential elongation of lateral epidermal cell sheets that close a dorsal hole filled with amnioserosa cells. Signaling pathways regulate the function of cellular structures and processes, including Actomyosin and microtubule cytoskeletons, cell-cell/cell-matrix adhesion complexes, and endocytosis/vesicle trafficking. Read More