651 results match your criteria Annual Review of Cell and Developmental Biology [Journal]


Cellular Mechanisms of NETosis.

Annu Rev Cell Dev Biol 2020 Jul 14. Epub 2020 Jul 14.

Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland, USA; email:

Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their host defense role by phagocytosing pathogens, secreting their granules full of cytotoxic enzymes, or expelling neutrophil extracellular traps (NETs) during the process of NETosis. NETs are weblike DNA structures decorated with histones and antimicrobial proteins released by activated neutrophils. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-020520-111016DOI Listing

Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance.

Annu Rev Cell Dev Biol 2020 Jul 7. Epub 2020 Jul 7.

Paediatric Allergy Research Group, Department of Women and Children's Health, School of Life Course Sciences, King's College London, SE1 7EH, United Kingdom; email:

Pediatric allergic disease is a significant health concern worldwide, and the prevalence of childhood eczema, asthma, allergic rhinitis, and food allergy continues to increase. Evidence to support specific interventions for the prevention of eczema, asthma, and allergic rhinitis is limited, and no consensus on prevention strategies has been reached. Randomized controlled trials investigating the prevention of food allergy via oral tolerance induction and the early introduction of allergenic foods have been successful in reducing peanut and egg allergy prevalence. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125346DOI Listing

Shaping Organs: Shared Structural Principles Across Kingdoms.

Annu Rev Cell Dev Biol 2020 Jul 6. Epub 2020 Jul 6.

Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, Singapore 117411; email:

Development encapsulates the morphogenesis of an organism from a single fertilized cell to a functional adult. A critical part of development is the specification of organ forms. Beyond the molecular control of morphogenesis, shape in essence entails structural constraints and thus mechanics. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-012820-103850DOI Listing

Scaling of Subcellular Structures.

Annu Rev Cell Dev Biol 2020 Jun 30. Epub 2020 Jun 30.

Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA; email:

As cells grow, the size and number of their internal organelles increase in order to keep up with increased metabolic requirements. Abnormal size of organelles is a hallmark of cancer and an important aspect of diagnosis in cytopathology. Most organelles vary in either size or number, or both, as a function of cell size, but the mechanisms that create this variation remain unclear. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-020520-113246DOI Listing

Integrating Chemistry and Mechanics: The Forces Driving Axon Growth.

Authors:
Kristian Franze

Annu Rev Cell Dev Biol 2020 Jun 30. Epub 2020 Jun 30.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom; email:

The brain is our most complex organ. During development, neurons extend axons, which may grow over long distances along well-defined pathways to connect to distant targets. Our current understanding of axon pathfinding is largely based on chemical signaling by attractive and repulsive guidance cues. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125157DOI Listing

The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing.

Annu Rev Cell Dev Biol 2020 Jun 24. Epub 2020 Jun 24.

Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; email:

The generation of all blood cell lineages (hematopoiesis) is sustained throughout the entire life span of adult mammals. Studies using cell transplantation identified the self-renewing, multipotent hematopoietic stem cells (HSCs) as the source of hematopoiesis in adoptive hosts and delineated a hierarchy of HSC-derived progenitors that ultimately yield mature blood cells. However, much less is known about adult hematopoiesis as it occurs in native hosts, i. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-020520-114601DOI Listing

Combinatorial Control of Plant Specialized Metabolism: Mechanisms, Functions, and Consequences.

Annu Rev Cell Dev Biol 2020 Jun 19. Epub 2020 Jun 19.

Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium; email:

Plants constantly perceive internal and external cues, many of which they need to address to safeguard their proper development and survival. They respond to these cues by selective activation of specific metabolic pathways involving a plethora of molecular players that act and interact in complex networks. In this review, we illustrate and discuss the complexity in the combinatorial control of plant specialized metabolism. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-011620-031429DOI Listing

Neurovascular Interactions in the Nervous System.

Annu Rev Cell Dev Biol 2019 10;35:615-635

Neuro and Vascular Guidance, Buchmann Institute for Molecular Life Sciences, University of Frankfurt, D-60438 Frankfurt am Main, Germany; email:

Molecular cross talk between the nervous and vascular systems is necessary to maintain the correct coupling of organ structure and function. Molecular pathways shared by both systems are emerging as major players in the communication of the neuronal compartment with the endothelium. Here we review different aspects of this cross talk and how vessels influence the development and homeostasis of the nervous system. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125142DOI Listing
October 2019
1 Read

Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management.

Annu Rev Cell Dev Biol 2019 10;35:501-521

Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA; email:

The dual leucine zipper-bearing kinase (DLK) and leucine zipper-bearing kinase (LZK) are evolutionarily conserved MAPKKKs of the mixed-lineage kinase family. Acting upstream of stress-responsive JNK and p38 MAP kinases, DLK and LZK have emerged as central players in neuronal responses to a variety of acute and traumatic injuries. Recent studies also implicate their function in astrocytes, microglia, and other nonneuronal cells, reflecting their expanding roles in the multicellular response to injury and in disease. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015696PMC
October 2019

Lipid Dynamics at Contact Sites Between the Endoplasmic Reticulum and Other Organelles.

Annu Rev Cell Dev Biol 2019 10;35:85-109

Section on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA; email:

Phospholipids are synthesized primarily within the endoplasmic reticulum and are subsequently distributed to various subcellular membranes to maintain the unique lipid composition of specific organelles. As a result, in most cases, the steady-state localization of membrane phospholipids does not match their site of synthesis. This raises the question of how diverse lipid species reach their final membrane destinations and what molecular processes provide the energy to maintain the lipid gradients that exist between various membrane compartments. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125251DOI Listing
October 2019

Introduction: The in the Age of Open Access.

Authors:
Ruth Lehmann

Annu Rev Cell Dev Biol 2019 10;35:v-vii

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http://dx.doi.org/10.1146/annurev-cb-35-091019-100001DOI Listing
October 2019

Plant Cell Polarity: Creating Diversity from Inside the Box.

Annu Rev Cell Dev Biol 2019 10;35:309-336

Howard Hughes Medical Institute, Stanford University, Stanford, California 94305-5020, USA; email:

Cell polarity in plants operates across a broad range of spatial and temporal scales to control processes from acute cell growth to systemic hormone distribution. Similar to other eukaryotes, plants generate polarity at both the subcellular and tissue levels, often through polarization of membrane-associated protein complexes. However, likely due to the constraints imposed by the cell wall and their extremely plastic development, plants possess novel polarity molecules and mechanisms highly tuned to environmental inputs. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125211DOI Listing
October 2019

Comparing Sensory Organs to Define the Path for Hair Cell Regeneration.

Annu Rev Cell Dev Biol 2019 10 25;35:567-589. Epub 2019 Sep 25.

Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA; email:

Deafness or hearing deficits are debilitating conditions. They are often caused by loss of sensory hair cells or defects in their function. In contrast to mammals, nonmammalian vertebrates robustly regenerate hair cells after injury. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125503DOI Listing
October 2019
1 Read

A Polarizing Issue: Diversity in the Mechanisms Underlying Apico-Basolateral Polarization In Vivo.

Annu Rev Cell Dev Biol 2019 10 28;35:285-308. Epub 2019 Aug 28.

Department of Biology, Stanford University, Stanford, California 94305, USA; email:

Polarization along an apico-basolateral axis is a hallmark of epithelial cells and is essential for their selective barrier and transporter functions, as well as for their ability to provide mechanical resiliency to organs. Loss of polarity along this axis perturbs development and is associated with a wide number of diseases. We describe three steps involved in polarization: symmetry breaking, polarity establishment, and polarity maintenance. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125134DOI Listing
October 2019
1 Read

Expansion Microscopy: Scalable and Convenient Super-Resolution Microscopy.

Annu Rev Cell Dev Biol 2019 10 19;35:683-701. Epub 2019 Aug 19.

Broad Institute of Harvard and MIT, Boston, Massachusetts 02142, USA; email:

Expansion microscopy (ExM) is a physical form of magnification that increases the effective resolving power of any microscope. Here, we describe the fundamental principles of ExM, as well as how recently developed ExM variants build upon and apply those principles. We examine applications of ExM in cell and developmental biology for the study of nanoscale structures as well as ExM's potential for scalable mapping of nanoscale structures across large sample volumes. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125320DOI Listing
October 2019
1 Read

Not Just Going with the Flow: The Effects of Fluid Flow on Bacteria and Plankton.

Annu Rev Cell Dev Biol 2019 10 14;35:213-237. Epub 2019 Aug 14.

Institute of Environmental Engineering, Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich, Switzerland; email:

Microorganisms often live in habitats characterized by fluid flow, from lakes and oceans to soil and the human body. Bacteria and plankton experience a broad range of flows, from the chaotic motion characteristic of turbulence to smooth flows at boundaries and in confined environments. Flow creates forces and torques that affect the movement, behavior, and spatial distribution of microorganisms and shapes the chemical landscape on which they rely for nutrient acquisition and communication. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125119DOI Listing
October 2019

A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing.

Authors:
Michael Sheetz

Annu Rev Cell Dev Biol 2019 10 14;35:169-190. Epub 2019 Aug 14.

Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, Singapore 117411.

For many years, major differences in morphology, motility, and mechanical characteristics have been observed between transformed cancer and normal cells. In this review, we consider these differences as linked to different states of normal and transformed cells that involve distinct mechanosensing and motility pathways. There is a strong correlation between repeated tissue healing and/or inflammation and the probability of cancer, both of which involve growth in adult tissues. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125227DOI Listing
October 2019
1 Read

Mechanics of Anteroposterior Axis Formation in Vertebrates.

Annu Rev Cell Dev Biol 2019 10 14;35:259-283. Epub 2019 Aug 14.

Department of Genetics, Harvard Medical School, and Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA; email:

The vertebrate anteroposterior axis forms through elongation of multiple tissues during embryogenesis. This process is based on tissue-autonomous mechanisms of force generation and intertissue mechanical coupling whose failure leads to severe developmental anomalies such as body truncation and spina bifida. Similar to other morphogenetic modules, anteroposterior body extension requires both the rearrangement of existing materials-such as cells and extracellular matrix-and the local addition of new materials, i. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125436DOI Listing
October 2019

Plant Noncoding RNAs: Hidden Players in Development and Stress Responses.

Annu Rev Cell Dev Biol 2019 10 12;35:407-431. Epub 2019 Aug 12.

Guangdong Provincial Key Laboratory of Plant Resources, State Key Laboratory for Biocontrol, and School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China; email:

A large and significant portion of eukaryotic transcriptomes consists of noncoding RNAs (ncRNAs) that have minimal or no protein-coding capacity but are functional. Diverse ncRNAs, including both small RNAs and long ncRNAs (lncRNAs), play essential regulatory roles in almost all biological processes by modulating gene expression at the transcriptional and posttranscriptional levels. In this review, we summarize the current knowledge of plant small RNAs and lncRNAs, with a focus on their biogenesis, modes of action, local and systemic movement, and functions at the nexus of plant development and environmental responses. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125218DOI Listing
October 2019

Coatopathies: Genetic Disorders of Protein Coats.

Annu Rev Cell Dev Biol 2019 10 9;35:131-168. Epub 2019 Aug 9.

Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland 20892, USA; email:

Protein coats are supramolecular complexes that assemble on the cytosolic face of membranes to promote cargo sorting and transport carrier formation in the endomembrane system of eukaryotic cells. Several types of protein coats have been described, including COPI, COPII, AP-1, AP-2, AP-3, AP-4, AP-5, and retromer, which operate at different stages of the endomembrane system. Defects in these coats impair specific transport pathways, compromising the function and viability of the cells. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310445PMC
October 2019

Cell Motility and Cytokinesis: From Mysteries to Molecular Mechanisms in Five Decades.

Authors:
Thomas D Pollard

Annu Rev Cell Dev Biol 2019 10 8;35:1-28. Epub 2019 Aug 8.

Departments of Molecular, Cellular and Developmental Biology; Molecular Biophysics and Biochemistry; and Cell Biology, Yale University, New Haven, Connecticut 06520-8103, USA; email:

This is the story of someone who has been fortunate to work in a field of research where essentially nothing was known at the outset but that blossomed with the discovery of profound insights about two basic biological processes: cell motility and cytokinesis. The field started with no molecules, just a few people, and primitive methods. Over time, technological advances in biophysics, biochemistry, and microscopy allowed the combined efforts of scientists in hundreds of laboratories to explain mysterious processes with molecular mechanisms that can be embodied in mathematical equations and simulated by computers. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125427DOI Listing
October 2019

Cellular Logistics: Unraveling the Interplay Between Microtubule Organization and Intracellular Transport.

Annu Rev Cell Dev Biol 2019 10 8;35:29-54. Epub 2019 Aug 8.

Department of Biology, Utrecht University, 3584 CH Utrecht, The Netherlands; email:

Microtubules are core components of the cytoskeleton and serve as tracks for motor protein-based intracellular transport. Microtubule networks are highly diverse across different cell types and are believed to adapt to cell type-specific transport demands. Here we review how the spatial organization of different subsets of microtubules into higher-order networks determines the traffic rules for motor-based transport in different animal cell types. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125149DOI Listing
October 2019

Developmental Responses to Water and Salinity in Root Systems.

Authors:
José R Dinneny

Annu Rev Cell Dev Biol 2019 10 5;35:239-257. Epub 2019 Aug 5.

Department of Biology, Stanford University, Stanford, California 94305, USA; email:

Roots provide the primary mechanism that plants use to absorb water and nutrients from their environment. These functions are dependent on developmental mechanisms that direct root growth and branching into regions of soil where these resources are relatively abundant. Water is the most limiting factor for plant growth, and its availability is determined by the weather, soil structure, and salinity. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062949DOI Listing
October 2019

Cell Reprogramming: The Many Roads to Success.

Annu Rev Cell Dev Biol 2019 10 23;35:433-452. Epub 2019 Jul 23.

Department of Biology, New York University, New York, NY 10003, USA; email:

Cellular reprogramming experiments from somatic cell types have demonstrated the plasticity of terminally differentiated cell states. Recent efforts in understanding the mechanisms of cellular reprogramming have begun to elucidate the differentiation trajectories along the reprogramming processes. In this review, we focus mainly on direct reprogramming strategies by transcription factors and highlight the variables that contribute to cell fate conversion outcomes. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125127DOI Listing
October 2019

Curving Cells Inside and Out: Roles of BAR Domain Proteins in Membrane Shaping and Its Cellular Implications.

Annu Rev Cell Dev Biol 2019 10 23;35:111-129. Epub 2019 Jul 23.

Laboratoire Physico Chimie Curie, CNRS UMR 168, Institut Curie, PSL Research University, 75005 Paris, France; email:

Many cellular processes rely on precise and timely deformation of the cell membrane. While many proteins participate in membrane reshaping and scission, usually in highly specialized ways, Bin/amphiphysin/Rvs (BAR) domain proteins play a pervasive role, as they not only participate in many aspects of cell trafficking but also are highly versatile membrane remodelers. Subtle changes in the shape and size of the BAR domain can greatly impact the way in which BAR domain proteins interact with the membrane. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-060558DOI Listing
October 2019

Autophagy in Neurons.

Annu Rev Cell Dev Biol 2019 10 23;35:477-500. Epub 2019 Jul 23.

Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA; email:

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. Autophagy is particularly important in neurons, which are terminally differentiated cells that must last the lifetime of the organism. There are both constitutive and stress-induced pathways for autophagy in neurons, which catalyze the turnover of aged or damaged mitochondria, endoplasmic reticulum, other cellular organelles, and aggregated proteins. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996145PMC
October 2019
10 Reads

Whole-Cell Models and Simulations in Molecular Detail.

Annu Rev Cell Dev Biol 2019 10 12;35:191-211. Epub 2019 Jul 12.

Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan.

Comprehensive data about the composition and structure of cellular components have enabled the construction of quantitative whole-cell models. While kinetic network-type models have been established, it is also becoming possible to build physical, molecular-level models of cellular environments. This review outlines challenges in constructing and simulating such models and discusses near- and long-term opportunities for developing physical whole-cell models that can connect molecular structure with biological function. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783340PMC
October 2019

Development and Cell Biology of the Blood-Brain Barrier.

Annu Rev Cell Dev Biol 2019 10 12;35:591-613. Epub 2019 Jul 12.

Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA; email:

The vertebrate vasculature displays high organotypic specialization, with the structure and function of blood vessels catering to the specific needs of each tissue. A unique feature of the central nervous system (CNS) vasculature is the blood-brain barrier (BBB). The BBB regulates substance influx and efflux to maintain a homeostatic environment for proper brain function. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062608DOI Listing
October 2019

Light-Sheet Microscopy and Its Potential for Understanding Developmental Processes.

Annu Rev Cell Dev Biol 2019 10 12;35:655-681. Epub 2019 Jul 12.

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA; email:

The ability to visualize and quantitatively measure dynamic biological processes in vivo and at high spatiotemporal resolution is of fundamental importance to experimental investigations in developmental biology. Light-sheet microscopy is particularly well suited to providing such data, since it offers exceptionally high imaging speed and good spatial resolution while minimizing light-induced damage to the specimen. We review core principles and recent advances in light-sheet microscopy, with a focus on concepts and implementations relevant for applications in developmental biology. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125311DOI Listing
October 2019

Low-Affinity Binding Sites and the Transcription Factor Specificity Paradox in Eukaryotes.

Annu Rev Cell Dev Biol 2019 10 5;35:357-379. Epub 2019 Jul 5.

Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10031, USA; email:

Eukaryotic transcription factors (TFs) from the same structural family tend to bind similar DNA sequences, despite the ability of these TFs to execute distinct functions in vivo. The cell partly resolves this specificity paradox through combinatorial strategies and the use of low-affinity binding sites, which are better able to distinguish between similar TFs. However, because these sites have low affinity, it is challenging to understand how TFs recognize them in vivo. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787930PMC
October 2019

Architecture and Dynamics of the Neuronal Secretory Network.

Annu Rev Cell Dev Biol 2019 10 5;35:543-566. Epub 2019 Jul 5.

Institute for Psychiatry and Neurosciences of Paris, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Paris, 75014 Paris, France; email:

Regulated synthesis and movement of proteins between cellular organelles are central to diverse forms of biological adaptation and plasticity. In neurons, the repertoire of channel, receptor, and adhesion proteins displayed on the cell surface directly impacts cellular development, morphology, excitability, and synapse function. The immensity of the neuronal surface membrane and its division into distinct functional domains present a challenging landscape over which proteins must navigate to reach their appropriate functional domains. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935261PMC
October 2019

The Fly Brain Atlas.

Annu Rev Cell Dev Biol 2019 10 8;35:637-653. Epub 2019 Jul 8.

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147-2408, USA; email:

The brain's synaptic networks endow an animal with powerfully adaptive biological behavior. Maps of such synaptic circuits densely reconstructed in those model brains that can be examined and manipulated by genetic means offer the best prospect for understanding the underlying biological bases of behavior. That prospect is now technologically feasible and a scientifically enabling possibility in neurobiology, much as genomics has been in molecular biology and genetics. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125444DOI Listing
October 2019

Developmental Cell Death in the Cerebral Cortex.

Annu Rev Cell Dev Biol 2019 10 5;35:523-542. Epub 2019 Jul 5.

Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom; email:

In spite of the high metabolic cost of cellular production, the brain contains only a fraction of the neurons generated during embryonic development. In the rodent cerebral cortex, a first wave of programmed cell death surges at embryonic stages and affects primarily progenitor cells. A second, larger wave unfolds during early postnatal development and ultimately determines the final number of cortical neurons. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125204DOI Listing
October 2019
1 Read
16.660 Impact Factor

Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development.

Annu Rev Cell Dev Biol 2019 10 5;35:381-406. Epub 2019 Jul 5.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63108, USA; email:

Innate immunity and adaptive immunity consist of highly specialized immune lineages that depend on transcription factors for both function and development. In this review, we dissect the similarities between two innate lineages, innate lymphoid cells (ILCs) and dendritic cells (DCs), and an adaptive immune lineage, T cells. ILCs, DCs, and T cells make up four functional immune modules and interact in concert to produce a specified immune response. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886469PMC
October 2019

Diverse Cellular Roles of Autophagy.

Annu Rev Cell Dev Biol 2019 10 5;35:453-475. Epub 2019 Jul 5.

Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; email:

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular functions of macroautophagy, including its essential contribution to metabolic adaptation and cellular homeostasis. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100818-125300DOI Listing
October 2019

Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface.

Annu Rev Cell Dev Biol 2019 10 5;35:55-84. Epub 2019 Jul 5.

National Centre for Biological Science, Tata Institute for Fundamental Research, Bangalore 560065, India; email:

Endocytosis has long been identified as a key cellular process involved in bringing in nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in maintaining cell membrane compositional homeostasis. While clathrin-mediated endocytosis has been most extensively studied, a number of clathrin-independent endocytic pathways are continuing to be delineated. Here we provide a current survey of the different types of endocytic pathways available at the cell surface and discuss a new classification and plausible molecular mechanisms for some of the less characterized pathways. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917507PMC
October 2019

Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease.

Annu Rev Cell Dev Biol 2019 10 18;35:337-356. Epub 2019 Mar 18.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA; email:

B cells play multiple important roles in the pathophysiology of autoimmune disease. Beyond producing pathogenic autoantibodies, B cells can act as antigen-presenting cells and producers of cytokines, including both proinflammatory and anti-inflammatory cytokines. Here we review our current understanding of the non-antibody-secreting roles that B cells may play during development of autoimmunity, as learned primarily from reductionist preclinical models. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062518DOI Listing
October 2019
14 Reads

Writing, Reading, and Translating the Clustered Protocadherin Cell Surface Recognition Code for Neural Circuit Assembly.

Annu Rev Cell Dev Biol 2018 10;34:471-493

Department of Biochemistry and Molecular Biophysics, Columbia University Medical School, and Zuckerman Institute, Columbia University, New York, NY 10027, USA; email:

The ability of neurites of individual neurons to distinguish between themselves and neurites from other neurons and to avoid self (self-avoidance) plays a key role in neural circuit assembly in both invertebrates and vertebrates. Similarly, when individual neurons of the same type project into receptive fields of the brain, they must avoid each other to maximize target coverage (tiling). Counterintuitively, these processes are driven by highly specific homophilic interactions between cell surface proteins that lead to neurite repulsion rather than adhesion. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100616-060701DOI Listing
October 2018
3 Reads
16.660 Impact Factor

Caveolae: Structure, Function, and Relationship to Disease.

Authors:
Robert G Parton

Annu Rev Cell Dev Biol 2018 10;34:111-136

Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, Queensland 4060, Australia; email:

The plasma membrane of eukaryotic cells is not a simple sheet of lipids and proteins but is differentiated into subdomains with crucial functions. Caveolae, small pits in the plasma membrane, are the most abundant surface subdomains of many mammalian cells. The cellular functions of caveolae have long remained obscure, but a new molecular understanding of caveola formation has led to insights into their workings. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062737DOI Listing
October 2018
3 Reads

Mucins and Their Role in Shaping the Functions of Mucus Barriers.

Annu Rev Cell Dev Biol 2018 10 11;34:189-215. Epub 2018 May 11.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email:

We review what is currently understood about how the structure of the primary solid component of mucus, the glycoprotein mucin, gives rise to the mechanical and biochemical properties of mucus that are required for it to perform its diverse physiological roles. Macroscale processes such as lubrication require mucus of a certain stiffness and spinnability, which are set by structural features of the mucin network, including the identity and density of cross-links and the degree of glycosylation. At the microscale, these same features affect the mechanical environment experienced by small particles and play a crucial role in establishing an interaction-based filter. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062818DOI Listing
October 2018
2 Reads

Regulation of Division and Differentiation of Plant Stem Cells.

Annu Rev Cell Dev Biol 2018 10 22;34:289-310. Epub 2018 Aug 22.

Department of Biology and Howard Hughes Medical Institute, Duke University, Durham, North Carolina 27708, USA; email:

A major challenge in developmental biology is unraveling the precise regulation of plant stem cell maintenance and the transition to a fully differentiated cell. In this review, we highlight major themes coordinating the acquisition of cell identity and subsequent differentiation in plants. Plant cells are immobile and establish position-dependent cell lineages that rely heavily on external cues. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556207PMC
October 2018
4 Reads

Kidney Nephron Determination.

Authors:
Leif Oxburgh

Annu Rev Cell Dev Biol 2018 10 20;34:427-450. Epub 2018 Aug 20.

Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA; email:

The nephron is a multifunctional filtration device equipped with an array of sophisticated sensors. For appropriate physiological function in the human and mouse, nephrons must be stereotypically arrayed in large numbers, and this essential structural property that defines the kidney is determined during its fetal development. This review explores the process of nephron determination in the fetal kidney, providing an overview of the foundational literature in the field as well as exploring new developments in this dynamic research area. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100616-060647DOI Listing
October 2018
4 Reads

Repertoires of tRNAs: The Couplers of Genomics and Proteomics.

Annu Rev Cell Dev Biol 2018 10 20;34:239-264. Epub 2018 Aug 20.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100 Israel; email:

The pool of transfer RNA (tRNA) molecules in cells allows the ribosome to decode genetic information. This repertoire of molecular decoders is positioned in the crossroad of the genome, the transcriptome, and the proteome. Omics and systems biology now allow scientists to explore the entire repertoire of tRNAs of many organisms, revealing basic exciting biology. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062754DOI Listing
October 2018
3 Reads

Organelle Formation in Bacteria and Archaea.

Annu Rev Cell Dev Biol 2018 10 16;34:217-238. Epub 2018 Aug 16.

Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA; email:

Uncovering the mechanisms that underlie the biogenesis and maintenance of eukaryotic organelles is a vibrant and essential area of biological research. In comparison, little attention has been paid to the process of compartmentalization in bacteria and archaea. This lack of attention is in part due to the common misconception that organelles are a unique evolutionary invention of the "complex" eukaryotic cell and are absent from the "primitive" bacterial and archaeal cells. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100616-060908DOI Listing
October 2018
6 Reads

Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases.

Annu Rev Cell Dev Biol 2018 10 15;34:29-58. Epub 2018 Aug 15.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom; email:

Cell adhesion to macromolecules in the microenvironment is essential for the development and maintenance of tissues, and its dysregulation can lead to a range of disease states, including inflammation, fibrosis, and cancer. The biomechanical and biochemical mechanisms that mediate cell adhesion rely on signaling by a range of effector proteins, including kinases and associated scaffolding proteins. The intracellular trafficking of these must be tightly controlled in space and time to enable effective cell adhesion and microenvironmental sensing and to integrate cell adhesion with, and compartmentalize it from, other cellular processes, such as gene transcription, protein degradation, and cell division. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062559DOI Listing
October 2018
4 Reads

Sortase A: A Model for Transpeptidation and Its Biological Applications.

Annu Rev Cell Dev Biol 2018 10 15;34:163-188. Epub 2018 Aug 15.

Program in Molecular and Cellular Medicine, Boston Children's Hospital, Boston, Massachusetts 02115, USA; email:

Molecular biologists and chemists alike have long sought to modify proteins with substituents that cannot be installed by standard or even advanced genetic approaches. We here describe the use of transpeptidases to achieve these goals. Living systems encode a variety of transpeptidases and peptide ligases that allow for the enzyme-catalyzed formation of peptide bonds, and protein engineers have used directed evolution to enhance these enzymes for biological applications. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062527DOI Listing
October 2018
9 Reads

Principles of Ubiquitin-Dependent Signaling.

Annu Rev Cell Dev Biol 2018 10 15;34:137-162. Epub 2018 Aug 15.

Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA; email:

Ubiquitylation is an essential posttranslational modification that controls cell division, differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers), ubiquitin-binding effectors (readers), and de-ubiquitylases (erasers) with functionally distinct ubiquitylation tags, the ubiquitin system constitutes a powerful signaling network that is employed in similar ways from yeast to humans. Here, we discuss conserved principles of ubiquitin-dependent signaling that illustrate how this posttranslational modification shapes intracellular signaling networks to establish robust development and homeostasis throughout the eukaryotic kingdom. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062802DOI Listing
October 2018
3 Reads
16.660 Impact Factor

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes.

Annu Rev Cell Dev Biol 2018 10 10;34:85-109. Epub 2018 Aug 10.

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA; email:

The endosomal sorting complexes required for transport (ESCRT) pathway mediates cellular membrane remodeling and fission reactions. The pathway comprises five core complexes: ALIX, ESCRT-I, ESCRT-II, ESCRT-III, and Vps4. These soluble complexes are typically recruited to target membranes by site-specific adaptors that bind one or both of the early-acting ESCRT factors: ALIX and ESCRT-I/ESCRT-II. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100616-060600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241870PMC
October 2018
4 Reads

Symmetry Breaking in the Mammalian Embryo.

Annu Rev Cell Dev Biol 2018 10 10;34:405-426. Epub 2018 Aug 10.

European Molecular Biology Laboratory, 69117 Heidelberg, Germany; email:

We present an overview of symmetry breaking in early mammalian development as a continuous process from compaction to specification of the body axes. While earlier studies have focused on individual symmetry-breaking events, recent advances enable us to explore progressive symmetry breaking during early mammalian development. Although we primarily discuss embryonic development of the mouse, as it is the best-studied mammalian model system to date, we also highlight the shared and distinct aspects between different mammalian species. Read More

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062616DOI Listing
October 2018
60 Reads