Annu Rev Biochem 2018 Jan 26. Epub 2018 Jan 26.
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel; email:
Proteins are increasingly used in basic and applied biomedical research.Many proteins, however, are only marginally stable and can be expressed in limited amounts, thus hampering research and applications. Research has revealed the thermodynamic, cellular, and evolutionary principles and mechanisms that underlie marginal stability. Read More