Annu Rev Biochem 2017 Aug 25. Epub 2017 Aug 25.
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390; email: ,
Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory discovered Scap, we have learned how it binds sterol regulatory element-binding proteins (SREBPs) and transports them from the endoplasmic reticulum (ER) to the Golgi for proteolytic processing. Proteolysis releases the SREBP transcription factor domains, which enter the nucleus to promote cholesterol synthesis and uptake. Read More