148,786 results match your criteria Annual Review Of Pathology-mechanisms Of Disease[Journal]


Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey.

Int Arch Allergy Immunol 2019 Apr 18:1-8. Epub 2019 Apr 18.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Background: Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known.

Objective: To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well as drug and healthcare costs.

Methods: Nationwide Allergy Barometer Survey was carried out in the Finnish pharmacies during 1 week in September 2016. Read More

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http://dx.doi.org/10.1159/000498861DOI Listing

Overview of bioremediation with technology assessment and emphasis on fungal bioremediation of oil contaminated soils.

J Environ Manage 2019 Apr 15;241:156-166. Epub 2019 Apr 15.

PROFNIT - Professional Post-Graduate Program in Intellectual Property and Technology Transfer for Innovation, Federal University of Bahia, Campus de Ondina, R. Barão de Jeremoabo, 147, Ondina, Salvador, BA, 40170-115, Brazil; José de Anchieta College, Av. João Durval Carneiro, n. 3039, São João, Feira de Santana, BA, 44051-605, Brazil. Electronic address:

Environmental contamination is a problem that requires sustainable solutions. Bioremediation technologies have been developed in the last decades and are increasingly used to mitigate environmental accidents and systematic contaminations. A review of bioremediation technologies, based on published article and patent documents, is presented for different types of contaminated matrices, bioremediation agents and contaminants. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.019DOI Listing

Degradation of brominated polymeric flame retardants and effects of generated decomposition products.

Chemosphere 2019 Apr 8;227:329-333. Epub 2019 Apr 8.

Aquatic Ecology and Centre for Water and Environmental Research (ZWU), University Duisburg-Essen, 45141, Essen, Germany.

Brominated flame retardants are often associated with adverse environmental effects. Nevertheless, these chemicals are required in order to comply with fire safety standards. Therefore, a better environmental profile is desirable. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.052DOI Listing

An integrated statistical and deterministic hydrologic model for analyzing trace organic contaminants in commercial and high-density residential stormwater runoff.

Sci Total Environ 2019 Apr 6;673:656-667. Epub 2019 Apr 6.

United States Geological Survey, Upper Midwest Water Science Center, 8505 Research Way, Middleton, WI 53562, USA.

Urbanization can dramatically alter stormwater, both the quantity and quality, by engendering larger peak flows and through the introduction of contaminants into runoff. The current study builds on previous research that developed relationships between a suite of nonpoint source contaminants, known as trace organic contaminants (TOrCs), and hydrologic measurements for a series of storms (one site had 15 storms and the other had 19 storms) in Madison, WI, by creating statistical and deterministic models. Correlations and regressions were calculated between TOrC loads and hydrologic measurements for a series of storms for both a commercial site and a high-density residential site. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193132
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http://dx.doi.org/10.1016/j.scitotenv.2019.03.327DOI Listing
April 2019
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Influence of cultivar, irrigation, ripening stage, and annual variability on the oxidant/antioxidant systems of olives as determined by MDS-PTA.

PLoS One 2019 18;14(4):e0215540. Epub 2019 Apr 18.

Department of Plant Biology, Ecology and Earth Sciences (Research Group FBCMP), Extremadura University, Badajoz, Spain.

The phenolic composition and content of olive fruit are some of the attributes that determine oil quality. This composition depends on the olive variety, the cultivation system, and the fruit's ripeness. This study considered two olive varieties (Manzanilla and Morisca), under two water regimes (irrigated and rainfed), harvested at three stages of maturation (S1, S2, and S3), over three consecutive campaigns (2011, 2012, and 2013). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215540PLOS

Barriers and facilitators of communication about off periods in Parkinson's disease: Qualitative analysis of patient, carepartner, and physician Interviews.

PLoS One 2019 18;14(4):e0215384. Epub 2019 Apr 18.

Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, Toronto, Ontario, Canada.

Background: Successful patient-physician communication is critical for improving health outcomes, but research regarding optimal communication practices in Parkinson's disease is limited. The objective of the current study was to investigate barriers and facilitators of communication between persons with Parkinson's disease, carepartners, and physicians, specifically in the setting of off periods, with the goal of identifying ways to improve patient-carepartner-physician communication.

Method: We interviewed persons with Parkinson's, carepartners, and physicians (specialists and non-specialists) using a semi-structured questionnaire to identify and describe experiences, barriers, and facilitators relating to communication about off periods in Parkinson's disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215384PLOS
April 2019
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Effects of hypoxia on survival, behavior, metabolism and cellular damage of Manila clam (Ruditapes philippinarum).

PLoS One 2019 18;14(4):e0215158. Epub 2019 Apr 18.

CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.

The Manila clam Ruditapes philippinarum has become a common and dominant macrobenthic species in coastal areas of the northwestern Pacific and temperate waters of Europe; it is also a major cultured shellfish, with annual worldwide production exceeding 3.3 million tonnes. This species faces greater risk of exposure to hypoxia as eutrophication worsens throughout its coastal habitats; however, its tolerance to hypoxia remains unclear, and the toxicological indicators including LC50 and LT50 have not yet been assessed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215158PLOS

Identifying chronic thromboembolic pulmonary hypertension through the French national hospital discharge database.

PLoS One 2019 18;14(4):e0214649. Epub 2019 Apr 18.

Bayer AG, Berlin, Germany.

Chronic thromboembolic pulmonary hypertension (CTEPH), a rare pulmonary vascular disease, is often misdiagnosed due to nonspecific symptoms. The objective of the study was to develop, refine and validate a case ascertainment algorithm to identify CTEPH patients within the French exhaustive hospital discharge database (PMSI), and to use it to estimate the annual number of hospitalized patients with CTEPH in France in 2015, as a proxy for disease prevalence. As ICD-10 coding specifically for CTEPH was not available at the time of the study, a case ascertainment algorithm was developed in close collaboration with an expert committee, using a two-step process (refinement and validation), based on matched data from PMSI and hospital medical records from 2 centres. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214649PLOS

Bilateral Femoroacetabular Impingement: What is the Fate of the Asymptomatic Hip?

Clin Orthop Relat Res 2019 May;477(5):983-989

I. Azboy , Department of Orthopaedics and Traumatology, Istanbul Medipol University School of Medicine, Istanbul, Turkey I. Azboy, H. H. Ceylan, H. Groff, H. Vahedi, J. Parvizi, The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Background: Bilateral symptomatic femoroacetabular impingement (FAI) is common. However, the fate of asymptomatic hip in patients with the radiographic diagnosis of bilateral FAI and unilateral symptoms remains unknown.

Questions/purposes: (1) What is the likelihood of the asymptomatic hip becoming painful in patients with unilateral symptoms but with radiographic evidence of bilateral femoroacetabular impingement? (2) What radiological and clinical factors are associated with the development of symptoms in an asymptomatic hip diagnosed with FAI?

Methods: A longitudinally maintained institutional FAI database was queried to collect relevant data for this retrospective study. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000699DOI Listing

Annual Award for an Essay by an Early-Career Scholar.

Hastings Cent Rep 2019 Mar;49(2)

As part of the celebrations of The Hastings Center's fiftieth anniversary, we are launching an annual prize, The David Roscoe Award for an Early-Career Scholar's Essay on Science, Ethics, and Society. The award is named in honor of David Roscoe, an accomplished essayist and recent past chair of the Hastings board. The award is intended to highlight the good scholarship that will take the field of bioethics forward into the next fifty years. Read More

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http://dx.doi.org/10.1002/hast.983DOI Listing

Migration triggers in a large herbivore: Galápagos giant tortoises navigating resource gradients on volcanoes.

Ecology 2019 Apr 18:e02658. Epub 2019 Apr 18.

Department of Environmental and Forest Biology, College of Environmental Science and Forestry, State University of New York, Syracuse, New York, 13210, USA.

To understand how migratory behavior evolved and to predict how migratory species will respond to global environmental change it is important to quantify the fitness consequences of intra- and inter-individual variation in migratory behavior. Intra-individual variation includes behavioral responses to changing environmental conditions and hence behavioral plasticity in the context of novel or variable conditions. Inter-individual variation determines the degree of variation on which selection can act and the rate of evolutionary responses to changes in average and extreme environmental conditions. Read More

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http://dx.doi.org/10.1002/ecy.2658DOI Listing

Actions developed by the Brazilian Physiological Society to promote women's participation in science.

Adv Physiol Educ 2019 Jun;43(2):199-206

Instituto do Coração, University of São Paulo , São Paulo , Brazil.

Here we described two activities related to Women in Science: one main conference and one symposium, both developed during the Annual Congress of the Brazilian Physiological Society, which were held within the XXXIII Annual Meeting of the Federation of Brazilian Experimental Biology Societies, from September 3-6, 2018, in Campos do Jordão (SP/Brazil). This conference and the symposium were among the most popular activities of the congress. This is important because the activities addressed important issues, including the fact that only 29% of the worlds' researchers are women, and women have difficulty progressing in a scientific career. Read More

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http://dx.doi.org/10.1152/advan.00216.2018DOI Listing

Community intervention to prevent adolescent health behavior problems: Evaluation of communities that care in Australia.

Health Psychol 2019 Apr 18. Epub 2019 Apr 18.

Centre for Adolescent Health, Murdoch Children's Research Institute.

Objective: A major challenge for health psychologists is to ensure the implementation of evidence-based interventions to improve population health. To reduce high rates of adolescent alcohol use and related health problems, trials of the Communities That Care (CTC) prevention process were implemented in Australia beginning in 2001. The process assists communities to strategically plan and monitor implementation of evidence-based preventative interventions. Read More

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http://dx.doi.org/10.1037/hea0000735DOI Listing

Economic Impact of Hospitalizations in US Adults with Sarcopenia.

J Frailty Aging 2019 ;8(2):93-99

Suzette Pereira, Abbott- Nutrition Division, Research and Development, 3300 Stelzer Road, Columbus, OH 43219 Phone: +1 614-624-4625, Fax: 614-727-4625, Email:

Background: Sarcopenia is characterized by progressive loss of muscle mass with corresponding decline in strength and/or physical function. The economic burden of sarcopenia-associated disability is considerable in the US.

Objective: To estimate the cost of hospitalizations in US adults with sarcopenia categorized by age, sex, and race/ethnicity. Read More

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http://www.jfrailtyaging.com/all-issues.html?article=721
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http://dx.doi.org/10.14283/jfa.2019.10DOI Listing
January 2019
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Tc activity concentrations in room air and resulting internal contamination of medical personnel during ventilation-perfusion lung scans.

Radiat Environ Biophys 2019 Apr 17. Epub 2019 Apr 17.

Institute of Physics, Jagiellonian University, Kraków, Poland.

This paper presents the results of measurements of Tc activity concentrations in indoor air in a nuclear medicine department and resulting estimated Tc intake by medical personnel. Tc air activity measurements were conducted at the Nuclear Medicine Department, John Paul II Hospital, Krakow, Poland, during ventilation-perfusion SPECT lung scans. Technetium from the air was collected by means of a mobile aerosol sampler with a Petryanov filter operating at an average flow rate of 10 dm min. Read More

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http://dx.doi.org/10.1007/s00411-019-00793-2DOI Listing

The Economic Burden of Asthma in Greece: A Cross-Sectional Study.

Appl Health Econ Health Policy 2019 Apr 17. Epub 2019 Apr 17.

EVROSTON LP, Chatzigianni Mexi 5, 115 28, Athens, Greece.

Background: The high prevalence rates of asthma worldwide and the chronic nature of the disease make asthma a major cause of morbidity, imposing a significant socio-economic burden in many countries. Specifically in Greece, the self-reported prevalence of asthma reached 9% in 2017.

Objectives: The objective of this study was to estimate the total management cost of asthma in Greece and its potential determinants. Read More

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http://link.springer.com/10.1007/s40258-019-00469-4
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http://dx.doi.org/10.1007/s40258-019-00469-4DOI Listing
April 2019
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Timeliness of HIV Diagnosis and Antiretroviral Treatment Initiation in the Era of Universal Test and Treat.

J Infect Dis 2019 Apr 4. Epub 2019 Apr 4.

Institute for Implementation Science in Population Health (ISPH), City University of New York (CUNY); New York City, New York USA.

Background: We describe the timing of HIV diagnosis and antiretroviral treatment (ART) initiation following implementation of universal test and treatment policies in New York City (NYC).

Methods: Using NYC population-based HIV Registry data for persons diagnosed from 2012 through 2015 and followed through June 2017, we examined trends in the proportion diagnosed early following HIV infection (i.e. Read More

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http://dx.doi.org/10.1093/infdis/jiz148DOI Listing

Changes in plasma phospholipid fatty acid profiles over 13 years and correlates of change: European Prospective Investigation into Cancer and Nutrition-Norfolk Study.

Am J Clin Nutr 2019 Apr 17. Epub 2019 Apr 17.

MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

Background: Little is known about changes in blood fatty acid compositions over time and the correlates of any changes in a general population.

Objective: The aim of this study was to estimate changes in 27 individual plasma phospholipid fatty acids and fatty acid groups over time, and to identify potential correlates of these changes.

Methods: Plasma phospholipid fatty acids were profiled at 3 time-points (1993-1997, 1998-2000, 2004-2011) among 722 participants in the European Prospective Investigation into Cancer and Nutrition-Norfolk Study, UK. Read More

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http://dx.doi.org/10.1093/ajcn/nqz030DOI Listing

SSII-Evap: Simplified scheme to incorporate improved evapotranspiration estimates into the streamflow elasticity framework.

MethodsX 2019 28;6:672-681. Epub 2019 Mar 28.

University of Warsaw, Faculty of Geography and Regional Studies, Department of Hydrology, Poland.

The streamflow elasticity concept based on the Budyko framework is widely used in hydrological impact assessment studies. However, in landscapes transformed by human activities, identification of climate contributions to runoff change is difficult due to changing surface properties of river basins. Here, a method is proposed to quantify the effects of changing vegetation cover and included them in the calculus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22150161193006
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http://dx.doi.org/10.1016/j.mex.2019.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453669PMC
March 2019
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Do the regular annual extreme water level changes affect the seasonal appearance of in Poyang Lake?

PeerJ 2019 12;7:e6608. Epub 2019 Apr 12.

Nanchang Institute of Technology, Nanchang, China.

Background: Poyang Lake is an ecosystem experiencing annual variations in water level of up to 14 m. Water level changes were 8.03 and 11. Read More

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http://dx.doi.org/10.7717/peerj.6608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463853PMC

Setting the international standard for longitudinal follow-up of patients with systemic sclerosis: a Delphi-based expert consensus on core clinical features.

RMD Open 2019 4;5(1):e000826. Epub 2019 Mar 4.

Rheumatology A Department, Universite Paris Descartes, Paris, France.

Background: Systemic sclerosis (SSc) is a severe, progressive multiorgan disease but to date, there are no established standardised international guidelines for follow-up of patients with SSc. The goal of this project was to develop an expert consensus for annual systematic investigations in patients with SSc to enhance their standard-of-care.

Material And Methods: The Delphi method was applied. Read More

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2018-00082
Publisher Site
http://dx.doi.org/10.1136/rmdopen-2018-000826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446182PMC
March 2019
1 Read

Standardising practice in cardiology: reducing clinical variation and cost at Ochsner Health System.

Open Heart 2019 22;6(1):e000994. Epub 2019 Mar 22.

QURE Healthcare, San Francisco, California, USA.

Objective: Low quality and unwarranted clinical variation harm patients and increase unnecessary costs. Effective approaches to improve clinical and economic value have been difficult. The Ochsner Health System looked to improve clinical care quality and reduce unnecessary costs in cardiology using active measurement and customised feedback. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443124PMC

Empowering podiatrists to perform pulse checks for opportunistic atrial fibrillation detection during annual diabetes foot checks.

Open Heart 2019 6;6(1):e000795. Epub 2019 Feb 6.

Academic Health Science Network North East and North Cumbria (AHSN), Biomedical Research Building, Campus for Ageing and Vitality, Newcastle, UK.

Objective: To determine whether training podiatrists to provide opportunistic screening for atrial fibrillation (AF) during the local diabetes foot check was feasible and whether it detects previously unknown AF.

Method: During the initiative, 45 podiatrists from across North Durham, Darlington and Durham Dales Easington and Sedgefield Clinical Commissioning Groups were trained to recognise heart irregularities when taking pulse readings of feet of patients with diabetes during their annual foot screening reviews.

Results: Over the course of the 3-month pilot, 5000 patients with diabetes had their feet pulse-tested. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443127PMC
February 2019

Budget Impact Model of Omadacycline on Replacing a Proportion of Existing Treatment Options Among Patients Who Present to the Emergency Department with Acute Bacterial Skin and Skin Structure Infections.

Am Health Drug Benefits 2019 Feb;12(1-Supplement 2):S13-S24

Professor, Albany College of Pharmacy and Health Sciences, NY.

Background: Omadacycline is an oral and intravenous (IV) once-daily aminomethylcycline antibiotic that is approved in the United States for the treatment of adults with acute bacterial skin and skin structure infections (ABSSSI). It has broad-spectrum activity against common causative pathogens of ABSSSI, including methicillin-resistant . Omadacycline has been shown to be noninferior to linezolid for the treatment of adults with ABSSSI across 2 phase 3 clinical trials. Read More

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February 2019

Determinants of scholarly project completion in a paediatric resident program in Canada.

Paediatr Child Health 2019 May 28;24(2):e98-e103. Epub 2018 Jun 28.

Department of Paediatrics and Child Health, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba.

Background: The primary aims of this study were to: 1) assess barriers and facilitators of completing scholarly projects from residents and faculty mentor perspectives, 2) determine the perceived value of new initiatives designed to support resident scholarly projects and 3) determine if these initiatives led to changes in resident publications.

Design And Methods: Between June and September 2014, we surveyed 18 paediatric residents and 41 faculty mentors regarding barriers to resident scholarly project completion and the value of new initiatives to support scholarly activity. We also tracked scientific publications by residents before and after implementation of these initiatives. Read More

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http://dx.doi.org/10.1093/pch/pxy089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462124PMC

Incidence and mortality of thyroid cancer in China, 20082012.

Chin J Cancer Res 2019 Feb;31(1):144-151

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100021, China.

Objective: To analyze the incidence and mortality rates of thyroid cancer (TC) in China from 2008 to 2012.

Methods: Incident and death cases of TC were retrieved from the National Central Cancer Registry (NCCR) database collecting from 135 cancer registries in China during 2008-2012. The crude incidence and mortality rates of TC were calculated by area (urban/rural), region (eastern, middle, western), gender and age group (0, 1-4, 5-9, …, 85+). Read More

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http://article.cjcrcn.org/en/article/doi/10.21147/j.issn.100
Publisher Site
http://dx.doi.org/10.21147/j.issn.1000-9604.2019.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433579PMC
February 2019
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Territoriality and variation in home range size through the entire annual range of migratory great spotted cuckoos (Clamator glandarius).

Sci Rep 2019 Apr 17;9(1):6238. Epub 2019 Apr 17.

Behavioural and Physiological Ecology group, Centre for Ecological and Evolutionary Studies, University of Groningen, 9700 CC, Groningen, The Netherlands.

Variation in home range size throughout the year and its causes are not well understood yet. Migratory brood parasites offer a unique opportunity to incorporate this spatio-temporal dimension into the study of the factors regulating home range dynamics. Using satellite transmitters, we tracked sixteen migratory great spotted cuckoos (Clamator glandarius) of both sexes for up to three years. Read More

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http://dx.doi.org/10.1038/s41598-019-41943-2DOI Listing

Closely-related Photobacterium strains comprise the majority of bacteria in the gut of migrating Atlantic cod (Gadus morhua).

Microbiome 2019 Apr 17;7(1):64. Epub 2019 Apr 17.

Department of Chemistry and the Center for Bioinformatics (SfB), Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037, Tromsø, Norway.

Background: The population of Atlantic cod (Gadus morhua), also known as Northeast Arctic cod, migrating Atlantic cod, or simply "skrei," lives mainly in the Barents Sea and Svalbard waters and migrates in annual cycles to the Norwegian coast in order to spawn eggs during late winter. It is the world's largest population of Atlantic cod, and the population is distinct from the Norwegian coastal cod (or "fjord" cod). Despite the biological, economic, and cultural importance of migrating Atlantic cod, current knowledge on the associated microbiota is very limited. Read More

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http://dx.doi.org/10.1186/s40168-019-0681-yDOI Listing

Cs-Based Variation of Soil Erosion in Vertical Zones of a Small Catchment in Southwestern China.

Int J Environ Res Public Health 2019 Apr 16;16(8). Epub 2019 Apr 16.

Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Chengdu 610041, China.

The study of the variability of soil erosion in mountainous areas provides the basis for soil and water conservation work and forest ecological construction in a targeted way. In this study, Liangshan Town catchment, a typical catchment in the Hengduan Mountains region, southwest China, was selected to investigate the variation of soil erosion in different vertical zones using the Cs tracing technique. The mean Cs reference inventories varied between 573. Read More

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https://www.mdpi.com/1660-4601/16/8/1371
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http://dx.doi.org/10.3390/ijerph16081371DOI Listing
April 2019
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Effects of Socio-Environmental Factors on Malaria Infection in Pakistan: A Bayesian Spatial Analysis.

Int J Environ Res Public Health 2019 Apr 16;16(8). Epub 2019 Apr 16.

School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.

The role of socio-environmental factors in shaping malaria dynamics is complex and inconsistent. Effects of socio-environmental factors on malaria in Pakistan at district level were examined. Annual malaria cases data were obtained from Directorate of Malaria Control Program, Pakistan. Read More

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http://dx.doi.org/10.3390/ijerph16081365DOI Listing

An assessment of climate change vulnerability for Important Bird Areas in the Bering Sea and Aleutian Arc.

PLoS One 2019 17;14(4):e0214573. Epub 2019 Apr 17.

US Fish and Wildlife Service, Anchorage, Alaska, United States of America.

Recently available downscaled ocean climate models for the Bering Sea and Aleutian Arc offer the opportunity to assess climate vulnerability for upper trophic level consumers such as marine birds. We analyzed seasonal and annual spatial projections from three climate models for two physical climate variables (seawater temperature and sea ice) and three forage variables (large copepods, euphausiids, and benthic infauna), comparing projected conditions from a recent time period (2003-2012) to a future time period (2030-2039). We focused the analyses on core areas within globally significant Important Bird Areas, and developed indices of the magnitude of projected change and vulnerability agreement among models. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214573PLOS
April 2019
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Phthalate Exposure and Breast Cancer Incidence: A Danish Nationwide Cohort Study.

J Clin Oncol 2019 Apr 17:JCO1802202. Epub 2019 Apr 17.

2 University of Southern Denmark, Odense, Denmark.

Purpose: Phthalate exposure is ubiquitous and especially high among users of drug products formulated with phthalates. Some phthalates mimic estradiol and may promote breast cancer. Existing epidemiologic studies on this topic are small, mostly not prospective, and have given inconsistent results. Read More

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https://ascopubs.org/doi/10.1200/JCO.18.02202
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http://dx.doi.org/10.1200/JCO.18.02202DOI Listing
April 2019
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The Status and Impact of Clinical Tumor Genome Sequencing.

Annu Rev Genomics Hum Genet 2019 Apr 17. Epub 2019 Apr 17.

Khalifa Bin Zayed Institute for Personalized Cancer Therapy and Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA; email:

Since the discovery that DNA alterations initiate tumorigenesis, scientists and clinicians have been exploring ways to counter these changes with targeted therapeutics. The sequencing of tumor DNA was initially limited to highly actionable hot spots-areas of the genome that are frequently altered and have an approved matched therapy in a specific tumor type. Large-scale genome sequencing programs quickly developed technological improvements that enabled the deployment of whole-exome and whole-genome sequencing technologies at scale for pristine sample materials in research environments. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015034DOI Listing

Estimated Long-term (1981-2016) Concentrations of Ambient Fine Particulate Matter across North America from Chemical Transport Modeling, Satellite Remote Sensing and Ground-based Measurements.

Environ Sci Technol 2019 Apr 17. Epub 2019 Apr 17.

Accurate data concerning historical fine particulate matter (PM2.5) concentrations are needed to assess long-term changes in exposure and associated health risks. We estimated historical PM2. Read More

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http://dx.doi.org/10.1021/acs.est.8b06875DOI Listing

Examining Australia's heaviest drinkers.

Aust N Z J Public Health 2019 Apr 17. Epub 2019 Apr 17.

Centre for Alcohol Policy Research, La Trobe University, Victoria.

Objective: This study examined the distribution of alcohol consumption in Australia, identifying the heaviest drinking 10% of the population and examining their sociodemographic characteristics and their alcohol consumption and purchasing practices.

Methods: Data came from the 2016 National Drug Strategy Household Survey and the 2013 International Alcohol Control Study. The heaviest drinking 10% of the population identified based on estimates of annual alcohol consumption. Read More

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http://dx.doi.org/10.1111/1753-6405.12901DOI Listing
April 2019
1 Read

Association of Adenoma and Proximal Sessile Serrated Polyp Detection Rates With Endoscopist Characteristics.

JAMA Surg 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio.

Importance: Research demonstrates adenoma detection rate (ADR) and proximal sessile serrated polyp detection rate (pSSPDR) are associated with endoscopist characteristics including sex, specialty, and years in practice. However, many studies have not adjusted for other risk factors associated with colonic neoplasia.

Objective: To assess the association between endoscopist characteristics and polyp detection after adjusting the factors included in previous studies as well as other factors. Read More

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2019.0564DOI Listing
April 2019
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Consumption of Euterpe edulis fruit by wildlife: implications for conservation and management of the Southern Brazilian Atlantic Forest.

An Acad Bras Cienc 2019 8;91(1):e20180537. Epub 2019 Apr 8.

Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Departamento de Fitotecnia, Rodovia Admar Gonzaga, 1346, Itacorubi, 88034-001 Florianópolis, SC, Brazil.

This study aimed to measure the wildlife consumption of Euterpe edulis fruit and use this data to discuss management possibilities. To estimate infructescence fruit volume consumed, collectors were installed in fruit-bearing palms. To characterize consumption from the ground, samples were placed next to fruiting palms. Read More

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http://dx.doi.org/10.1590/0001-3765201920180537DOI Listing

Development of an annual drought classification system based on drought severity indexes.

An Acad Bras Cienc 2019 8;91(1):e20180188. Epub 2019 Apr 8.

Instituto Federal de Educação, Ciência e Tecnologia do Espírito Santo, Unidade Colatina, Av. Arino Gomes Leal, 1700, Santa Margarida, 29700-060 Colatina, ES, Brazil.

In order to characterize the occurrence and intensity of droughts in the Doce River Basin, as well as to develop a system for its classification, four different drought indexes were evaluated: Percent of Normal Precipitation (PNP), Deciles Method (DM), Rainfall Anomaly Index (RAI) and Standardized Precipitation Index (SPI). The indices were calculated annually, based on precipitation data from 89 rainfall stations of the Brazilian National Water Agency (ANA). Nine analysis units (AUs) were determined in the basin and the Thiessen Polygons method was used to obtain the average precipitation in the respective drainage areas. Read More

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http://dx.doi.org/10.1590/0001-3765201920180188DOI Listing
April 2019
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Establishing Consensus on the Best Practice Guidelines for Use of Halo Gravity Traction for Pediatric Spinal Deformity.

J Pediatr Orthop 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopaedic Surgery, Columbia University Medical Center, New York.

Background: Although halo gravity traction (HGT) has been used to treat children with severe spinal deformity for decades, there is a distinct lack of high-quality evidence to speak to its merits or to dictate ideal manner of implementation. In addition, no guidelines exist to drive research or assist surgeons in their practice. The aim of this study was to establish best practice guidelines (BPG) using formal techniques of consensus building among a group of experienced pediatric spinal deformity surgeons to determine ideal indications and implementation of HGT for pediatric spinal deformity. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001379DOI Listing
April 2019
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Costs and Trends of Emergency Department Utilization Pre-ACA and Post-ACA: Evidence From a Rural Georgia Hospital.

Med Care 2019 Apr 15. Epub 2019 Apr 15.

College of Allied Health Sciences, Augusta University.

Background: A high volume of emergency department (ED) visits in the rural United States may be the result of barriers to accessing primary care. The Affordable Care Act (ACA) increased the number of insured, which may improve patient access to primary care and therefore reduce ED utilization. The objective of this study is to estimate the trends and cost of ED utilization pre-ACA and post-ACA implementation in a rural United States. Read More

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http://dx.doi.org/10.1097/MLR.0000000000001114DOI Listing
April 2019
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Trends and Characteristics Associated with HPV Vaccination Uptake Among Men Who Have Sex with Men in the United States, 2014 - 2017.

Sex Transm Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Epidemiology, Rollins School of Public Health, Emory University; Atlanta, GA.

Background: Human papillomavirus (HPV) and HPV-associated cancer rates are high among men who have sex with men (MSM). The US Advisory Committee on Immunization Practices (ACIP) recommends HPV vaccination for all MSM through age 26. We examined trends in HPV vaccine uptake among young US MSM between 2014-2017. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001008DOI Listing

Telehealth Intervention Programs for Seniors: An Observational Study of a Community-Embedded Health Monitoring Initiative.

Telemed J E Health 2019 Apr 17. Epub 2019 Apr 17.

1 Department of Telemedicine and Virtual Rehabilitation, Burke Medical Research Institute, White Plains, New York.

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http://dx.doi.org/10.1089/tmj.2018.0248DOI Listing

[Effects of multiple times of topdressing nitrogen application under equal level on utilization and distribution characteristics of N and C in winter jujube].

Ying Yong Sheng Tai Xue Bao 2019 Apr;30(4):1380-1388

Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta, Binzhou University, Binzhou 256603, Shandong, China.

We explored the effects of multiple times of topdressing nitrogen application under equal level on the characteristics of absorption, utilization, accumulation, and distribution of N and C in four-year-old potted winter jujube during fruit developmental periods using the stable isotope tra-cer technology. The results showed that with the increases of nitrogen application times, the N derived from fertilizer (Ndff) in each organ significantly increased at the fruit maturity. The distribution rates of N in reproductive organ (fruit) and vegetative organs (leaf, deciduous spur, new branch, and fine root) were highest under four-time application, and lowest under one-time application. Read More

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http://dx.doi.org/10.13287/j.1001-9332.201904.029DOI Listing

[Effects of different nitrogen fertilizers on annual emissions of greenhouse gas from maize field in Northeast China].

Ying Yong Sheng Tai Xue Bao 2019 Apr;30(4):1303-1311

Institute of Agricultural Resources and Environment, Jilin Academy of Agricultural Sciences/State Engineering Laboratory of Maize, Changchun 130033, China.

A field experiment was conducted to investigate the greenhouse gas emission at high latitude farmland in Northeast China. We monitored the greenhouse gas emission using the static chamber-gas chromatography method. Four nitrogen (N) fertilizers were used: conventional N fertilization (CN), slow release fertilizer (SLN), urea plus nitrification inhibitor and urease inhibitor (NIUI), and no nitrogen fertilizer (NN). Read More

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http://dx.doi.org/10.13287/j.1001-9332.201904.030DOI Listing

[Effect of reducing N and regulated fertilization on N loss from wheat-maize rotation system of farmland in Chao soil region of North China Plain].

Ying Yong Sheng Tai Xue Bao 2019 Apr;30(4):1179-1187

Institute of Agricultural Resources and Environment, Shandong Academy of Agricultural Sciences, Ji'nan 250100, China.

The application of large amounts of nitrogen (N) fertilizer can result in soil N accumulation and consequently N loss. To address these problems in a wheat-maize rotation area of the North China Plain, a two-year field experiment (2016-2017) was conducted to examine the effects of three different N fertilizer strategies on crop yield, N uptake, N loss and soil inorganic N content. The treatments were: controlled-release fertilizer, microbial fertilizer, nitrification inhibitor and farmer's practice (control). Read More

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http://dx.doi.org/10.13287/j.1001-9332.201904.019DOI Listing

Changing epidemiology of meticillin-resistant in 42 hospitals in the Dutch-German border region, 2012 to 2016: results of the search-and-follow-policy.

Euro Surveill 2019 Apr;24(15)

University of Groningen, University Medical Center Groningen, Department of Medical Microbiology and Infection Prevention, Groningen, Netherlands.

IntroductionMeticillin-resistant (MRSA) is a major cause of healthcare-associated infections.AimWe describe MRSA colonisation/infection and bacteraemia rate trends in Dutch-German border region hospitals (NL-DE-BRH) in 2012-16.MethodsAll 42 NL-DE BRH (8 NL-BRH, 34 DE-BRH) within the cross-border network EurSafety Health-net provided surveillance data (on average ca 620,000 annual hospital admissions, of these 68. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1800244DOI Listing

The Investment Case for Malaria Elimination in Thailand: A Cost-Benefit Analysis.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

RTI International, Washington, District of Columbia.

After a dramatic decline in the annual malaria incidence in Thailand since 2000, the Thai government developed a National Malaria Elimination Strategy (NMES) to end local malaria transmission by 2024. This study examines the expected costs and benefits of funding the NMES (elimination scenario) versus not funding malaria elimination programming (resurgence scenario) from 2017 to 2036. Two case projection approaches were used to measure the number of malaria cases over the study period, combined with a set of Thailand-specific economic assumptions, to evaluate the cost of a malaria case and to quantify the cost-benefit ratio. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0897DOI Listing

A hierarchical Bayesian Beta regression approach to study the effects of geographic genetic structure and spatial autocorrelation on species distribution range shifts.

Mol Ecol Resour 2019 Apr 16. Epub 2019 Apr 16.

CREAF, E08193 Bellaterra (Cerdanyola del Vallès), Catalonia, Spain.

Global climate change (GCC) may be imposing distribution range shifts in many organisms worldwide. Multiple efforts are currently focused on the development of models to better predict distribution range shifts due to GCC. We addressed this issue by including intra-specific genetic structure and spatial autocorrelation (SAC) of data in distribution range models. Read More

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http://dx.doi.org/10.1111/1755-0998.13024DOI Listing