Annu Rev Neurosci 2021 Dec 22. Epub 2021 Dec 22.
Neuroscience Program, Department of Psychology, and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts, USA; email:
When navigating through space, we must maintain a representation of our position in real time; when recalling a past episode, a memory can come back in a flash. Interestingly, the brain's spatial representation system, including the hippocampus, supports these two distinct timescale functions. How are neural representations of space used in the service of both real-world navigation and internal mnemonic processes? Recent progress has identified sequences of hippocampal place cells, evolving at multiple timescales in accordance with either navigational behaviors or internal oscillations, that underlie these functions. Read More