10 results match your criteria Annual Review Of Fluid Mechanics[Journal]

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Immersed Methods for Fluid-Structure Interaction.

Annu Rev Fluid Mech 2020 5;52:421-448. Epub 2019 Sep 5.

Department of Mechanical Engineering, Northwestern University, Evanston, Illinois 60208, USA.

Fluid-structure interaction is ubiquitous in nature and occurs at all biological scales. Immersed methods provide mathematical and computational frameworks for modeling fluid-structure systems. These methods, which typically use an Eulerian description of the fluid and a Lagrangian description of the structure, can treat thin immersed boundaries and volumetric bodies, and they can model structures that are flexible or rigid or that move with prescribed deformational kinematics. Read More

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September 2019

Lymphatic System Flows.

Annu Rev Fluid Mech 2018 Jan;50:459-482

School of Mathematics and Statistics, University of Sydney, Australia.

The supply of oxygen and nutrients to tissues is performed by the blood system, and involves a net leakage of fluid outward at the capillary level. One of the principal functions of the lymphatic system is to gather this fluid and return it to the blood system to maintain overall fluid balance. Fluid in the interstitial spaces is often at subatmospheric pressure, and the return points into the venous system are at pressures of approximately 20 cmHO. Read More

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January 2018

Wall-Modeled Large-Eddy Simulation for Complex Turbulent Flows.

Annu Rev Fluid Mech 2018 Jan;50:535-561

Center for Turbulence Research, Stanford University, Stanford, California 94305.

Large-eddy simulation (LES) has proven to be a computationally tractable approach to simulate unsteady turbulent flows. However, prohibitive resolution requirements induced by near-wall eddies in high-Reynolds number boundary layers necessitate the use of wall models or approximate wall boundary conditions. We review recent investigations in wall-modeled LES, including the development of novel approximate boundary conditions and the application of wall models to complex flows (e. Read More

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January 2018

Green Algae as Model Organisms for Biological Fluid Dynamics.

Annu Rev Fluid Mech 2015 Jan;47:343-375

Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, United Kingdom.

In the past decade the volvocine green algae, spanning from the unicellular to multicellular , have emerged as model organisms for a number of problems in biological fluid dynamics. These include flagellar propulsion, nutrient uptake by swimming organisms, hydrodynamic interactions mediated by walls, collective dynamics and transport within suspensions of microswimmers, the mechanism of phototaxis, and the stochastic dynamics of flagellar synchronization. Green algae are well suited to the study of such problems because of their range of sizes (from 10 m to several millimetres), their geometric regularity, the ease with which they can be cultured and the availability of many mutants that allow for connections between molecular details and organism-level behavior. Read More

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January 2015

Fluid Mechanics of Blood Clot Formation.

Annu Rev Fluid Mech 2015 Jan;47:377-403

Department of Chemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401.

Intravascular blood clots form in an environment in which hydrodynamic forces dominate and in which fluid-mediated transport is the primary means of moving material. The clotting system has evolved to exploit fluid dynamic mechanisms and to overcome fluid dynamic challenges to ensure that clots that preserve vascular integrity can form over the wide range of flow conditions found in the circulation. Fluid-mediated interactions between the many large deformable red blood cells and the few small rigid platelets lead to high platelet concentrations near vessel walls where platelets contribute to clotting. Read More

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January 2015

Fluid Mechanics, Arterial Disease, and Gene Expression.

Annu Rev Fluid Mech 2014 Jan;46:591-614

Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322.

This review places modern research developments in vascular mechanobiology in the context of hemodynamic phenomena in the cardiovascular system and the discrete localization of vascular disease. The modern origins of this field are traced, beginning in the 1960s when associations between flow characteristics, particularly blood flow-induced wall shear stress, and the localization of atherosclerotic plaques were uncovered, and continuing to fluid shear stress effects on the vascular lining endothelial) cells (ECs), including their effects on EC morphology, biochemical production, and gene expression. The earliest single-gene studies and genome-wide analyses are considered. Read More

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January 2014

Fluid and Solute Transport in Bone: Flow-Induced Mechanotransduction.

Annu Rev Fluid Mech 2009 Jan;41:347-374

Department of Biomedical Engineering, City College of New York, New York, New York 10031.

Much recent evidence suggests that bone cells sense their mechanical environment via interstitial fluid flow. In this review, we summarize theoretical and experimental approaches to quantify fluid and solute transport in bone, starting with the early investigations of fluid shear stress applied to bone cells. The pathways of bone interstitial fluid and solute movement are high-lighted based on recent theoretical models, as well as a new generation of tracer experiments that have clarified and refined the structure and function of the osteocyte pericellular matrix. Read More

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January 2009

Hemodynamics of Cerebral Aneurysms.

Annu Rev Fluid Mech 2009 Jan;41:91-107

Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030.

The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. Read More

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January 2009

Microcirculation and Hemorheology.

Annu Rev Fluid Mech 2005 Jan;37:43-69

Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205;

Major experimental and theoretical studies on microcirculation and hemorheology are reviewed with the focus on mechanics of blood flow and the vascular wall. Flow of the blood formed elements (red blood cells (RBCs), white blood cells or leukocytes (WBCs) and platelets) in individual arterioles, capillaries and venules, and in microvascular networks is discussed. Mechanical and rheological properties of the formed elements and their interactions with the vascular wall are reviewed. Read More

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January 2005

Cellular fluid mechanics.

Roger D Kamm

Annu Rev Fluid Mech 2002 ;34:211-32

Department of Mechanical Engineering and Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

The coupling of fluid dynamics and biology at the level of the cell is an intensive area of investigation because of its critical role in normal physiology and disease. Microcirculatory flow has been a focus for years, owing to the complexity of cell-cell or cell-glycocalyx interactions. Noncirculating cells, particularly those that comprise the walls of the circulatory system, experience and respond biologically to fluid dynamic stresses. Read More

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