234 results match your criteria Annual Review Of Chemical And Biomolecular Engineering[Journal]


How Do Cells Adapt? Stories Told in Landscapes.

Annu Rev Chem Biomol Eng 2020 Jun;11:155-182

The Louis and Beatrice Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, New York 11794, USA; email:

Cells adapt to changing environments. Perturb a cell and it returns to a point of homeostasis. Perturb a population and it evolves toward a fitness peak. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-011720-103410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291840PMC

Mechanistic Modeling of Preparative Column Chromatography for Biotherapeutics.

Annu Rev Chem Biomol Eng 2020 Jun;11:235-255

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, USA; email:

Chromatography has long been, and remains, the workhorse of downstream processing in the production of biopharmaceuticals. As bioprocessing has matured, there has been a growing trend toward seeking a detailed fundamental understanding of the relevant unit operations, which for some operations include the use of mechanistic modeling in a way similar to its use in the conventional chemical process industries. Mechanistic models of chromatography have been developed for almost a century, but although the essential features are generally understood, the specialization of such models to biopharmaceutical processing includes several areas that require further elucidation. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-102419-125430DOI Listing
June 2020
8.676 Impact Factor

Introduction.

Annu Rev Chem Biomol Eng 2020 Jun;11:i-ii

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http://dx.doi.org/10.1146/annurev-ch-11-042120-100001DOI Listing

Life and Times in Engineering and Chemical Engineering.

Authors:
J F Davidson

Annu Rev Chem Biomol Eng 2020 Jun;11:23-34

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom.

John Davidson was widely recognized as the founding father of fluidization in chemical engineering. He was a great thinker and had a tremendous ability to distill complicated problems into much simpler concepts. Much of his thinking was set out, along with that of his coauthor David Harrison, in their book , first published in 1963, a book that is still used today. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-011420-125935DOI Listing

Molecular Modeling and Simulations of Peptide-Polymer Conjugates.

Annu Rev Chem Biomol Eng 2020 Jun;11:257-276

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, USA; email:

Peptide-polymer conjugates are a class of soft materials composed of covalently linked blocks of protein/polypeptides and synthetic/natural polymers. These materials are practically useful in biological applications, such as drug delivery, DNA/gene delivery, and antimicrobial coatings, as well as nonbiological applications, such as electronics, separations, optics, and sensing. Given their broad applicability, there is motivation to understand the molecular and macroscale structure, dynamics, and thermodynamic behavior exhibited by such materials. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-092319-083243DOI Listing

Cellular Automata in Chemistry and Chemical Engineering.

Annu Rev Chem Biomol Eng 2020 Jun;11:87-108

Mendeleev University of Chemical Technology of Russia, 125480 Moscow, Russian Federation; email:

We review the modern state of cellular automata (CA) applications for solving practical problems in chemistry and chemical technology. We consider the problems of material structure modeling and prediction of materials' morphology-dependent properties. We review the use of the CA approach for modeling diffusion, crystallization, dissolution, erosion, corrosion, adsorption, and hydration processes. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-093019-075250DOI Listing

Water Treatment: Are Membranes the Panacea?

Annu Rev Chem Biomol Eng 2020 Jun 7;11:559-585. Epub 2020 Apr 7.

Department of Civil, Architectural, and Environmental Engineering, The University of Texas at Austin, Austin, Texas 78712, USA; email:

Alongside the rising global water demand, continued stress on current water supplies has sparked interest in using nontraditional source waters for energy, agriculture, industry, and domestic needs. Membrane technologies have emerged as one of the most promising approaches to achieve water security, but implementation of membrane processes for increasingly complex waters remains a challenge. The technical feasibility of membrane processes replacing conventional treatment of alternative water supplies (e. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-111919-091940DOI Listing

Hydrolysis and Solvolysis as Benign Routes for the End-of-Life Management of Thermoset Polymer Waste.

Annu Rev Chem Biomol Eng 2020 Jun 6;11:183-201. Epub 2020 Apr 6.

Department of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas 77204-4004, USA; email:

The production of thermoset polymers is increasing globally owing to their advantageous properties, particularly when applied as composite materials. Though these materials are traditionally used in more durable, longer-lasting applications, ultimately, they become waste at the end of their usable lifetimes. Current recycling practices are not applicable to traditional thermoset waste, owing to their network structures and lack of processability. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-120919-012253DOI Listing

Numerical Methods for the Solution of Population Balance Equations Coupled with Computational Fluid Dynamics.

Annu Rev Chem Biomol Eng 2020 Jun 6;11:339-366. Epub 2020 Apr 6.

Department of Applied Science and Technology, Institute of Chemical Engineering, Politecnico di Torino, 10129 Torino, Italy; email:

This review article discusses the solution of population balance equations, for the simulation of disperse multiphase systems, tightly coupled with computational fluid dynamics. Although several methods are discussed, the focus is on quadrature-based moment methods (QBMMs) with particular attention to the quadrature method of moments, the conditional quadrature method of moments, and the direct quadrature method of moments. The relationship between the population balance equation, in its generalized form, and the Euler-Euler multiphase flow models, notably the two-fluid model, is thoroughly discussed. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-092319-075814DOI Listing

Covalent Organic Frameworks in Separation.

Annu Rev Chem Biomol Eng 2020 Jun 30;11:131-153. Epub 2020 Mar 30.

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China; email:

In the wake of sustainable development, materials research is going through a green revolution that is putting energy-efficient and environmentally friendly materials and methods in the limelight. In this quest for greener alternatives, covalent organic frameworks (COFs) have emerged as a new generation of designable crystalline porous polymers for a wide array of clean-energy and environmental applications. In this contribution, we categorically review the merits and shortcomings of COF bulk powders, nanosheets, freestanding thin films/membranes, and membranes on porous supports in various separation processes, including separation of gases, pervaporation, organic solvent nanofiltration, water purification, radionuclide sequestration, and chiral separations, with particular reference to COF material pore size, host-guest interactions, stability, selectivity, and permeability. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-112019-084830DOI Listing
June 2020
8.676 Impact Factor

Positron Emission Particle Tracking of Granular Flows.

Annu Rev Chem Biomol Eng 2020 Jun 30;11:367-396. Epub 2020 Mar 30.

School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.

Positron emission particle tracking (PEPT) is a noninvasive technique capable of imaging the three-dimensional dynamics of a wide variety of powders, particles, grains, and/or fluids. The PEPT technique can track the motion of particles with high temporal and spatial resolution and can be used to study various phenomena in systems spanning a broad range of scales, geometries, and physical states. We provide an introduction to the PEPT technique, an overview of its fundamental principles and operation, and a brief review of its application to a diverse range of scientific and industrial systems. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-011620-120633DOI Listing

Life Cycle Assessment for the Design of Chemical Processes, Products, and Supply Chains.

Annu Rev Chem Biomol Eng 2020 Jun 27;11:203-233. Epub 2020 Mar 27.

Institute of Technical Thermodynamics, RWTH Aachen University, 52062 Aachen, Germany; email:

Design in the chemical industry increasingly aims not only at economic but also at environmental targets. Environmental targets are usually best quantified using the standardized, holistic method of life cycle assessment (LCA). The resulting life cycle perspective poses a major challenge to chemical engineering design because the design scope is expanded to include process, product, and supply chain. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-011520-075844DOI Listing

Multiscale Lithium-Battery Modeling from Materials to Cells.

Annu Rev Chem Biomol Eng 2020 Jun 25;11:277-310. Epub 2020 Mar 25.

Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom; email:

New experimental technology and theoretical approaches have advanced battery research across length scales ranging from the molecular to the macroscopic. Direct observations of nanoscale phenomena and atomistic simulations have enhanced the understanding of the fundamental electrochemical processes that occur in battery materials. This vast and ever-growing pool of microscopic data brings with it the challenge of isolating crucial performance-decisive physical parameters, an effort that often requires the consideration of intricate interactions across very different length scales and timescales. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-012120-083016DOI Listing

Process Control and Energy Efficiency.

Annu Rev Chem Biomol Eng 2020 Jun 23;11:423-445. Epub 2020 Mar 23.

McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA; email:

We review the impact of control systems and strategies on the energy efficiency of chemical processes. We show that, in many ways, good control performance is a necessary but not sufficient condition for energy efficiency. The direct effect of process control on energy efficiency is manyfold: Reducing output variability allows for operating chemical plants closer to their limits, where the energy/economic optima typically lie. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-092319-083227DOI Listing

Separation Processes to Provide Pure Enantiomers and Plant Ingredients.

Annu Rev Chem Biomol Eng 2020 Jun 20;11:469-502. Epub 2020 Mar 20.

Max Planck Institute for Dynamics of Complex Technical Systems, D-39106 Magdeburg, Germany; email:

Enantiomer separation and the isolation of natural products from plants pose challenging separation problems resulting from the similarity of molecules and the number of compounds present in synthesis or extract mixtures. Furthermore, limited theory is available to predict productivities for possible alternative separation techniques. The application and performance of chromatography- and crystallization-based processes are demonstrated for various case studies devoted to isolating valuable target compounds from complex initial mixtures. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-100419-103732DOI Listing

Glycosylation of IgG and IgG-Like Recombinant Therapeutic Proteins: Why Is It Important and How Can We Control It?

Annu Rev Chem Biomol Eng 2020 Jun 16;11:311-338. Epub 2020 Mar 16.

Cell Culture and Fermentation Sciences, AstraZeneca, Gaithersburg, Maryland 20878, USA; email:

Regulatory bodies worldwide consider glycosylation to be a critical quality attribute for immunoglobulin G (IgG) and IgG-like therapeutics. This consideration is due to the importance of posttranslational modifications in determining the efficacy, safety, and pharmacokinetic properties of biologics. Given its critical role in protein therapeutic production, we review glycosylation beginning with an overview of the myriad interactions of glycans with other biological factors. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-102419-010001DOI Listing

Water Structure and Properties at Hydrophilic and Hydrophobic Surfaces.

Annu Rev Chem Biomol Eng 2020 Jun 13;11:523-557. Epub 2020 Mar 13.

Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA; email:

The properties of water on both molecular and macroscopic surfaces critically influence a wide range of physical behaviors, with applications spanning from membrane science to catalysis to protein engineering. Yet, our current understanding of water interfacing molecular and material surfaces is incomplete, in part because measurement of water structure and molecular-scale properties challenges even the most advanced experimental characterization techniques and computational approaches. This review highlights progress in the ongoing development of tools working to answer fundamental questions on the principles that govern the interactions between water and surfaces. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-120919-114657DOI Listing

Possibilities and Limits of Computational Fluid Dynamics-Discrete Element Method Simulations in Process Engineering: A Review of Recent Advancements and Future Trends.

Annu Rev Chem Biomol Eng 2020 Jun 13;11:397-422. Epub 2020 Mar 13.

Institute of Solids Process Engineering and Particle Technology, Hamburg University of Technology, 21073 Hamburg, Germany; email:

Fluid-solid systems play a major role in a wide variety of industries, from pharmaceutical and consumer goods to chemical plants and energy generation. Along with this variety of fields comes a diversity in apparatuses and applications, most prominently fluidized and spouted beds, granulators and mixers, pneumatic conveying, drying, agglomeration, coating, and combustion. The most promising approach for modeling the flow in these systems is the CFD-DEM method, coupling computational fluid dynamics (CFD) for the fluid phase and the discrete element method (DEM) for the particles. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-110519-075414DOI Listing

Quorum Sensing Communication: Molecularly Connecting Cells, Their Neighbors, and Even Devices.

Annu Rev Chem Biomol Eng 2020 Jun 13;11:447-468. Epub 2020 Mar 13.

Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA; email:

Quorum sensing (QS) is a molecular signaling modality that mediates molecular-based cell-cell communication. Prevalent in nature, QS networks provide bacteria with a method to gather information from the environment and make decisions based on the intel. With its ability to autonomously facilitate both inter- and intraspecies gene regulation, this process can be rewired to enable autonomously actuated, but molecularly programmed, genetic control. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-101519-124728DOI Listing

Bioprivileged Molecules: Integrating Biological and Chemical Catalysis for Biomass Conversion.

Annu Rev Chem Biomol Eng 2020 Jun 10;11:63-85. Epub 2020 Mar 10.

Center for Biorenewable Chemicals and Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, USA; email:

Further development of biomass conversions to viable chemicals and fuels will require improved atom utilization, process efficiency, and synergistic allocation of carbon feedstock into diverse products, as is the case in the well-developed petroleum industry. The integration of biological and chemical processes, which harnesses the strength of each type of process, can lead to advantaged processes over processes limited to one or the other. This synergy can be achieved through bioprivileged molecules that can be leveraged to produce a diversity of products, including both replacement molecules and novel molecules with enhanced performance properties. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-101519-121127DOI Listing

Biological Assembly of Modular Protein Building Blocks as Sensing, Delivery, and Therapeutic Agents.

Annu Rev Chem Biomol Eng 2020 Jun 10;11:35-62. Epub 2020 Mar 10.

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, USA; email:

Nature has evolved a wide range of strategies to create self-assembled protein nanostructures with structurally defined architectures that serve a myriad of highly specialized biological functions. With the advent of biological tools for site-specific protein modifications and de novo protein design, a wide range of customized protein nanocarriers have been created using both natural and synthetic biological building blocks to mimic these native designs for targeted biomedical applications. In this review, different design frameworks and synthetic decoration strategies for achieving these functional protein nanostructures are summarized. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-101519-121526DOI Listing

Unconventional Catalytic Approaches to Ammonia Synthesis.

Annu Rev Chem Biomol Eng 2020 Jun 10;11:503-521. Epub 2020 Mar 10.

Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, USA; email:

Ammonia is a critically important industrial chemical and is largely responsible for sustaining the growing global population. To provide ammonia to underdeveloped regions and/or regions far from industrial production hubs, modular systems have been targeted and often involve unconventional production methodologies. These novel approaches for ammonia production can tap renewable resources at smaller scales located at the point of use, while decreasing the CO footprint. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-092319-080240DOI Listing

Computational Fluid Dynamics for Fixed Bed Reactor Design.

Annu Rev Chem Biomol Eng 2020 Jun 9;11:109-130. Epub 2020 Mar 9.

Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, USA; email:

Flow, heat, and mass transfer in fixed beds of catalyst particles are complex phenomena and, when combined with catalytic reactions, are multiscale in both time and space; therefore, advanced computational techniques are being applied to fixed bed modeling to an ever-greater extent. The fast-growing literature on the use of computational fluid dynamics (CFD) in fixed bed design reflects the rapid development of this subfield of reactor modeling. We identify recent trends and research directions in which successful methodology has been established, for example, in computer generation of packings of complex particles, and where more work is needed, for example, in the meshing of nonsphere packings and the simulation of industrial-size packed tubes. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-092319-075328DOI Listing

A ChemE Grows in Brooklyn.

Authors:
Carol K Hall

Annu Rev Chem Biomol Eng 2020 Jun 9;11:1-22. Epub 2020 Mar 9.

Chemical and Biomolecular Engineering Department, North Carolina State University, Raleigh, North Carolina 27695, USA; email:

I profile my personal and professional journey from being a girl of the 1950s, with expectations typical for the times, to a chemical engineering professor and still-enthusiastic researcher. I describe my family, my early education, my college and graduate school training in physics, my postdoc years in chemistry, and my subsequent transformation into a chemical engineering faculty member-one of the first women to be appointed to a chemical engineering faculty in the United States. I focus on the events that shaped me, the people who noticed and supported me, and the environment for women scientists and engineers in what some would call the "early days. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-101519-120354DOI Listing

Responsive Polymers as Smart Nanomaterials Enable Diverse Applications.

Annu Rev Chem Biomol Eng 2019 06;10:361-382

Department of Chemical and Biological Engineering and Princeton Institute for the Science and Technology of Materials, Princeton University, Princeton, New Jersey 08544, USA; email:

Responsive polymers undergo reversible or irreversible physical or chemical modifications in response to a change in environment or stimulus, e.g., temperature, pH, light, and magnetic or electric fields. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030155DOI Listing
June 2019
5 Reads
8.676 Impact Factor

Perspectives on Low-Temperature Electrolysis and Potential for Renewable Hydrogen at Scale.

Annu Rev Chem Biomol Eng 2019 06;10:219-239

Nel ASA, 0278 Oslo, Norway; email:

Hydrogen is an important part of any discussion on sustainability and reduction in emissions across major energy sectors. In addition to being a feedstock and process gas for many industrial processes, hydrogen is emerging as a fuel alternative for transportation applications. Renewable sources of hydrogen are therefore required to increase in capacity. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-chembioeng
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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030241DOI Listing
June 2019
10 Reads

Polymer-Based Marine Antifouling and Fouling Release Surfaces: Strategies for Synthesis and Modification.

Annu Rev Chem Biomol Eng 2019 06;10:241-264

Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, USA; email:

In marine industries, the accumulation of organic matter and marine organisms on ship hulls and instruments limits performance, requiring frequent maintenance and increasing fuel costs. Current coatings technology to combat this biofouling relies heavily on the use of toxic, biocide-containing paints. These pose a serious threat to marine ecosystems, affecting both target and nontarget organisms. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030401DOI Listing
June 2019
3 Reads

Nanoparticles for Biomedicine: Coagulation During Synthesis and Applications.

Annu Rev Chem Biomol Eng 2019 06;10:155-174

Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, CH-8092 Zurich, Switzerland; email: ,

Nanoparticle-based systems offer fascinating possibilities for biomedicine, but their translation into clinics is slow. Missing sterile, reproducible, and scalable methods for their synthesis along with challenges in characterization and poor colloidal stability of nanoparticles in body fluids are key obstacles. Flame aerosol technology gives proven access to scalable synthesis of nanoparticles with diverse compositions and architectures. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030203DOI Listing
June 2019
2 Reads

Electrochemical Conversion of Biomass-Based Oxygenated Compounds.

Annu Rev Chem Biomol Eng 2019 06;10:85-104

Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, Michigan 48202, USA; email: ,

Dwindling fossil fuel resources and substantial release of CO from their processing have increased the appeal to use biomass as a sustainable platform for synthesis of chemicals and fuels. Steps toward this will require selective upgrading of biomass to suitable intermediates. Traditionally, biomass upgrading has involved thermochemical processes that require excessive amounts of petrochemical-derived H and suffer from poor product selectivity. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030148DOI Listing
June 2019
1 Read

Glückliche Reise.

Authors:
John M Prausnitz

Annu Rev Chem Biomol Eng 2019 06;10:1-15

Department of Chemical & Biomolecular Engineering, University of California, Berkeley, California 94720, USA; email:

Following Forest Hills High School in New York City, I attended Cornell University for a five-year program leading to a Bachelor of Chemical Engineering degree. After spending one year at the University of Rochester to obtain a Master of Science in Chemical Engineering, I came to Princeton University in 1951. Four years later, with a fresh PhD, I joined the faculty at the University of California, Berkeley, where I remained, interrupted only by sabbatical leaves in Switzerland, Germany, England, New Zealand, and Australia. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030112DOI Listing

Introduction.

Annu Rev Chem Biomol Eng 2019 06;10:i-ii

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http://dx.doi.org/10.1146/annurev-ch-10-041719-100001DOI Listing
June 2019
2 Reads

Protein and Peptide Biomaterials for Engineered Subunit Vaccines and Immunotherapeutic Applications.

Annu Rev Chem Biomol Eng 2019 06;10:337-359

School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-2000, USA; email:

Although vaccines have been the primary defense against widespread infectious disease for decades, there is a critical need for improvement to combat complex and variable diseases. More control and specificity over the immune response can be achieved by using only subunit components in vaccines. However, these often lack sufficient immunogenicity to fully protect, and conjugation or carrier materials are required. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030347DOI Listing
June 2019
1 Read

Advances in the Use of Microfluidics to Study Crystallization Fundamentals.

Annu Rev Chem Biomol Eng 2019 06 24;10:59-83. Epub 2019 Apr 24.

Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France; email: , , ,

This review compares droplet-based microfluidic systems used to study crystallization fundamentals in chemistry and biology. An original high-throughput droplet-based microfluidic platform is presented. It uses nanoliter droplets, generates a chemical library, and directly solubilizes powder, thus economizing both material and time. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030312DOI Listing
June 2019
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Colloidal Materials for 3D Printing.

Annu Rev Chem Biomol Eng 2019 06 5;10:17-42. Epub 2019 Apr 5.

Lawrence Livermore National Laboratory, Livermore, California 94550, USA; email:

In recent years, 3D printing has led to a disruptive manufacturing revolution that allows complex architected materials and structures to be created by directly joining sequential layers into designed 3D components. However, customized feedstocks for specific 3D printing techniques and applications are limited or nonexistent, which greatly impedes the production of desired structural or functional materials. Colloids, with their stable biphasic nature, have tremendous potential to satisfy the requirements of various 3D printing methods owing to their tunable electrical, optical, mechanical, and rheological properties. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-chembioeng
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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030133DOI Listing
June 2019
23 Reads

Does Chemical Engineering Research Have a Reproducibility Problem?

Annu Rev Chem Biomol Eng 2019 06 27;10:43-57. Epub 2019 Mar 27.

School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0100, USA; email:

Concerns have been raised in multiple scientific fields in recent years about the reproducibility of published results. Systematic efforts to examine this issue have been undertaken in biomedicine and psychology, but less is known about this important issue in the materials-oriented research that underpins much of modern chemical engineering. Here, we relate a dramatic historical episode from our own institution to illustrate the implications of performing reproducible research and describe two case studies based on literature analysis to provide concrete information on the reproducibility of modern materials-oriented research. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030323DOI Listing
June 2019
1 Read

Toward Sustainable Chemical Engineering: The Role of Process Systems Engineering.

Authors:
Bhavik R Bakshi

Annu Rev Chem Biomol Eng 2019 06 27;10:265-288. Epub 2019 Mar 27.

Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, USA; email:

Products from chemical engineering are essential for human well-being, but they also contribute to the degradation of ecosystem goods and services that are essential for sustaining all human activities. To contribute to sustainability, chemical engineering needs to address this paradox by developing chemical products and processes that meet the needs of present and future generations. Unintended harm of chemical engineering has usually appeared outside the discipline's traditional system boundary due to shifting of impacts across space, time, flows, or disciplines, and exceeding nature's capacity to supply goods and services. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030332DOI Listing
June 2019
2 Reads

On Radical-Induced Ignition in Combustion Systems.

Annu Rev Chem Biomol Eng 2019 06 22;10:199-217. Epub 2019 Mar 22.

Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544, USA; email:

This article reviews recent theoretical developments on incipient ignition induced by radical runaway in systems described by detailed chemistry. Employing eigenvalue analysis, we first analyze the canonical explosion limits of mixtures of hydrogen and oxygen, yielding explicit criteria that well reproduce their characteristic Z-shaped response in the pressure-temperature plot. Subsequently, we evaluate the role of hydrogen addition to the explosion limits of mixtures of oxygen with either carbon monoxide or methane, demonstrating and quantifying its strong catalytic effect, especially for the carbon monoxide cases. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030141DOI Listing
June 2019
2 Reads

Thermodynamic Principles for the Design of Polymers for Drug Formulations.

Annu Rev Chem Biomol Eng 2019 06 22;10:311-335. Epub 2019 Mar 22.

Institut für Technische Thermodynamik und Kältetechnik, Karlsruher Institut für Technologie, 76131 Karlsruhe, Germany; email:

Polymers play an essential role in drug formulation and production of medical devices, implants, and diagnostics. Following drug discovery, an appropriate formulation is selected to enable drug delivery. This task can be exceedingly challenging owing to the large number of potential delivery methods and formulation and process variables that can interact in complex ways. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030304DOI Listing
June 2019
1 Read

Pretreatment Processes of Biomass for Biorefineries: Current Status and Prospects.

Annu Rev Chem Biomol Eng 2019 06 20;10:289-310. Epub 2019 Mar 20.

BioEcoUVa, Research Institute on Bioeconomy, Group of High-Pressure Technology, Department of Chemical Engineering and Environmental Technology, University of Valladolid, Vallodolid 47011, Spain; email:

This article seeks to be a handy document for the academy and the industry to get quickly up to speed on the current status and prospects of biomass pretreatment for biorefineries. It is divided into two biomass sources: vegetal and animal. Vegetal biomass is the material produced by plants on land or in water (algae), consuming sunlight, CO, water, and soil nutrients. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030354DOI Listing
June 2019
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Modeling Segregation in Granular Flows.

Annu Rev Chem Biomol Eng 2019 06 18;10:129-153. Epub 2019 Mar 18.

Department of Mechanical Engineering, Northwestern University, Evanston, Illinois 60208, USA; email:

Accurate continuum models of flow and segregation of dense granular flows are now possible. This is the result of extensive comparisons, over the last several years, of computer simulations of increasing accuracy and scale, experiments, and continuum models, in a variety of flows and for a variety of mixtures. Computer simulations-discrete element methods (DEM)-yield remarkably detailed views of granular flow and segregation. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030122DOI Listing
June 2019
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Harnessing Nature's Anaerobes for Biotechnology and Bioprocessing.

Annu Rev Chem Biomol Eng 2019 06 18;10:105-128. Epub 2019 Mar 18.

Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA; email: , , , , ,

Industrial biotechnology has the potential to decrease our reliance on petroleum for fuel and bio-based chemical production and also enable valorization of waste streams. Anaerobic microorganisms thrive in resource-limited environments and offer an array of novel bioactivities in this regard that could revolutionize biomanufacturing. However, they have not been adopted for widespread industrial use owing to their strict growth requirements, limited number of available strains, difficulty in scale-up, and genetic intractability. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030340DOI Listing
June 2019
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Enabling Applications of Covalent Adaptable Networks.

Annu Rev Chem Biomol Eng 2019 06 18;10:175-198. Epub 2019 Mar 18.

Department of Chemical Engineering, University of Colorado Boulder, Boulder, Colorado 80309, USA; email: , , , ,

The ability to behave in a fluidlike manner fundamentally separates thermoset and thermoplastic polymers. Bridging this divide, covalent adaptable networks (CANs) structurally resemble thermosets with permanent covalent crosslinks but are able to flow in a manner that resembles thermoplastic behavior only when a dynamic chemical reaction is active. As a consequence, the rheological behavior of CANs becomes intrinsically tied to the dynamic reaction kinetics and the stimuli that are used to trigger those, including temperature, light, and chemical stimuli, providing unprecedented control over viscoelastic properties. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060718-030217DOI Listing
June 2019
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Introduction.

Annu Rev Chem Biomol Eng 2018 06;9

Santa Barbara, CA Spring 2018.

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http://dx.doi.org/10.1146/annurev-ch-09-052418-100001DOI Listing
June 2018
11 Reads

The Energy Future.

Annu Rev Chem Biomol Eng 2018 06;9:153-174

JDC Phosphate, Fort Meade, Florida 33841, USA.

The foreseeable energy future will be driven by economics of known technologies and the desire to reduce CO emissions to the atmosphere. Renewable energy options are compared with each other and with the use of fossil fuels with carbon capture and sequestration (CCS). Economic analysis is used to determine the best of several alternatives. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060817-084300DOI Listing
June 2018
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Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing.

Annu Rev Chem Biomol Eng 2018 06;9:253-281

Small Molecule Design and Development, Eli Lilly and Company, Lilly Research Laboratory, Indianapolis, Indiana 48525, USA; email: ,

The pharmaceutical industry has found new applications for the use of continuous processing for the manufacture of new therapies currently in development. The transformation has been encouraged by regulatory bodies as well as driven by cost reduction, decreased development cycles, access to new chemistries not practical in batch, improved safety, flexible manufacturing platforms, and improved product quality assurance. The transformation from batch to continuous manufacturing processing is the focus of this review. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-chembioeng
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http://dx.doi.org/10.1146/annurev-chembioeng-060817-084355DOI Listing
June 2018
7 Reads

Molecular Modelling for Reactor Design.

Authors:
Frerich J Keil

Annu Rev Chem Biomol Eng 2018 06;9:201-227

Department of Chemical Engineering, Hamburg University of Technology, D-21073 Hamburg, Germany; email:

Chemical reactor modelling based on insights and data on a molecular level has become reality over the last few years. Multiscale models describing elementary reaction steps and full microkinetic schemes, pore structures, multicomponent adsorption and diffusion inside pores, and entire reactors have been presented. Quantum mechanical (QM) approaches, molecular simulations (Monte Carlo and molecular dynamics), and continuum equations have been employed for this purpose. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060817-084141DOI Listing
June 2018
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Microkinetic Analysis and Scaling Relations for Catalyst Design.

Annu Rev Chem Biomol Eng 2018 06 11;9:413-450. Epub 2018 Apr 11.

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA; email: , ,

Microkinetic analysis plays an important role in catalyst design because it provides insight into the fundamental surface chemistry that controls catalyst performance. In this review, we summarize the development of microkinetic models and the inclusion of scaling relationships in these models. We discuss the importance of achieving stoichiometric and thermodynamic consistency in developing microkinetic models. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060817-084103DOI Listing
June 2018
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Advances in Multicompartment Mesoporous Silica Micro/Nanoparticles for Theranostic Applications.

Annu Rev Chem Biomol Eng 2018 06 4;9:389-411. Epub 2018 Apr 4.

Vice-Chancellor's Office, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom; email:

Mesoporous silica nanoparticles (MSNs) are promising functional nanomaterials for a variety of biomedical applications, such as bioimaging, drug/gene delivery, and cancer therapy. This is due to their low density, low toxicity, high biocompatibility, large specific surface areas, and excellent thermal and mechanical stability. The past decade has seen rapid advances in the development of MSNs with multiple compartments. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060817-084225DOI Listing
June 2018
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Nanoscale Optical Microscopy and Spectroscopy Using Near-Field Probes.

Annu Rev Chem Biomol Eng 2018 06 29;9:365-387. Epub 2018 Mar 29.

Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California 93106, USA; email: ,

Light-matter interactions can provide a wealth of detailed information about the structural, electronic, optical, and chemical properties of materials through various excitation and scattering processes that occur over different length, energy, and timescales. Unfortunately, the wavelike nature of light limits the achievable spatial resolution for interrogation and imaging of materials to roughly λ/2 because of diffraction. Scanning near-field optical microscopy (SNOM) breaks this diffraction limit by coupling light to nanostructures that are specifically designed to manipulate, enhance, and/or extract optical signals from very small regions of space. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-chembioeng
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http://dx.doi.org/10.1146/annurev-chembioeng-060817-084150DOI Listing
June 2018
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Shale Gas Implications for C-C Olefin Production: Incumbent and Future Technology.

Authors:
Eric E Stangland

Annu Rev Chem Biomol Eng 2018 06 29;9:341-364. Epub 2018 Mar 29.

Corporate Research & Development, The Dow Chemical Company, Midland, Michigan 48674, USA; email:

Substantial natural gas liquids recovery from tight shale formations has produced a significant boon for the US chemical industry. As fracking technology improves, shale liquids may represent the same for other geographies. As with any major industry disruption, the advent of shale resources permits both the chemical industry and the community an excellent opportunity to have open, foundational discussions on how both public and private institutions should research, develop, and utilize these resources most sustainably. Read More

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http://dx.doi.org/10.1146/annurev-chembioeng-060817-084345DOI Listing
June 2018
2 Reads