Annu Rev Biophys Biomol Struct 2007 ;36:131-50
Howard Hughes Medical Institute, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Covalent attachment of ubiquitin-like proteins (Ubls) is a predominant mechanism for regulating protein function in eukaryotes. Several structurally related Ubls, such as ubiquitin, SUMO, NEDD8, and ISG15, modify a vast number of proteins, altering their functions in a variety of ways. Ubl modifications can affect the target's half-life, subcellular localization, enzymatic activity, or ability to interact with protein or DNA partners. Read More