400 results match your criteria Annual Review Of Biomedical Engineering[Journal]


Integrated Biophysical Modeling and Image Analysis: Application to Neuro-Oncology.

Annu Rev Biomed Eng 2020 Jun;22:309-341

Oden Institute of Computational Engineering and Sciences, The University of Texas at Austin, Austin, Texas 78712, USA; email:

Central nervous system (CNS) tumors come with vastly heterogeneous histologic, molecular, and radiographic landscapes, rendering their precise characterization challenging. The rapidly growing fields of biophysical modeling and radiomics have shown promise in better characterizing the molecular, spatial, and temporal heterogeneity of tumors. Integrative analysis of CNS tumors, including clinically acquired multi-parametric magnetic resonance imaging (mpMRI) and the inverse problem of calibrating biophysical models to mpMRI data, assists in identifying macroscopic quantifiable tumor patterns of invasion and proliferation, potentially leading to improved () detection/segmentation of tumor subregions and () computer-aided diagnostic/prognostic/predictive modeling. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121105DOI Listing

Physiological Modeling and Simulation-Validation, Credibility, and Application.

Annu Rev Biomed Eng 2020 Jun;22:185-206

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA; email:

In this review, we discuss the science of model validation as it applies to physiological modeling. There is widespread disagreement and ambiguity about what constitutes model validity. In areas in which models affect real-world decision-making, including within the clinic, in regulatory science, or in the design and engineering of novel therapeutics, this question is of critical importance. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-082219-051740DOI Listing

Point-of-Care Devices to Detect Zika and Other Emerging Viruses.

Annu Rev Biomed Eng 2020 Jun;22:371-386

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email:

Rapid diagnostic tests (point-of-care devices) are critical components of informed patient care and public health monitoring (surveillance applications). We propose that among the many rapid diagnostics platforms that have been tested or are in development, lateral flow immunoassays and synthetic biology-based diagnostics (including CRISPR-based diagnostics) represent the best overall options given their ease of use, scalability for manufacturing, sensitivity, and specificity. This review describes the identification of lateral flow immunoassay monoclonal antibody pairs that detect and distinguish between closely related pathogens and that are used in combination with functionalized multicolored nanoparticles and computational methods to deconvolute data. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052240DOI Listing

Micromechanobiology: Focusing on the Cardiac Cell-Substrate Interface.

Annu Rev Biomed Eng 2020 Jun;22:257-284

Department of Mechanical Engineering, University of California, Santa Barbara, California 93106, USA; email:

Engineered, in vitro cardiac cell and tissue systems provide test beds for the study of cardiac development, cellular disease processes, and drug responses in a dish. Much effort has focused on improving the structure and function of engineered cardiomyocytes and heart tissues. However, these parameters depend critically on signaling through the cellular microenvironment in terms of ligand composition, matrix stiffness, and substrate mechanical properties-that is, matrix micromechanobiology. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-092019-034950DOI Listing

Mitigating the Consequences of Subconcussive Head Injuries.

Annu Rev Biomed Eng 2020 Jun 29;22:387-407. Epub 2020 Apr 29.

Department of Emergency Medicine, Stanford University, Palo Alto, California 94304, USA.

Subconcussive head injury represents a pathophysiology that spans the expertise of both clinical neurology and biomechanical engineering. From both viewpoints, the terms injury and damage, presented without qualifiers, are synonymously taken to mean a tissue alteration that may be recoverable. For clinicians, concussion is evolving from a purely clinical diagnosis to one that requires objective measurement, to be achieved by biomedical engineers. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-091219-053447DOI Listing

Elastin-Like Polypeptides for Biomedical Applications.

Annu Rev Biomed Eng 2020 Jun 28;22:343-369. Epub 2020 Apr 28.

Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA; email:

Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human elastin. Their unique properties-including lower critical solution temperature phase behavior and minimal immunogenicity-make them attractive materials for a variety of biomedical applications. ELPs also benefit from recombinant synthesis and genetically encoded design; these enable control over the molecular weight and precise incorporation of peptides and pharmacological agents into the sequence. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-092419-061127DOI Listing

Computer-Aided Design of Microfluidic Circuits.

Annu Rev Biomed Eng 2020 Jun 28;22:285-307. Epub 2020 Apr 28.

Neuro-Biomorphic Engineering Lab (NBEL), Department of Mathematics and Computer Science, The Open University of Israel, Ra'anana 4353701, Israel; email:

Microfluidic devices developed over the past decade feature greater intricacy, increased performance requirements, new materials, and innovative fabrication methods. Consequentially, new algorithmic and design approaches have been developed to introduce optimization and computer-aided design to microfluidic circuits: from conceptualization to specification, synthesis, realization, and refinement. The field includes the development of new description languages, optimization methods, benchmarks, and integrated design tools. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-082219-033358DOI Listing

Engineering Approaches for Addressing Opioid Use Disorder in the Community.

Authors:
Paul M Griffin

Annu Rev Biomed Eng 2020 Jun 7;22:207-229. Epub 2020 Apr 7.

Regenstrief Center for Healthcare Engineering and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA; email:

Many communities in the United States are struggling to deal with the negative consequences of illicit opioid use. Effectively addressing this epidemic requires the coordination and support of community stakeholders in a change process with common goals and objectives, continuous engagement with individuals with opioid use disorder (OUD) through their treatment and recovery journeys, application of systems engineering principles to drive process change and sustain it, and use of a formal evaluation process to support a learning community that continuously adapts. This review presents strategies to improve OUD treatment and recovery with a focus on engineering approaches grounded in systems thinking. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-082719-040832DOI Listing

Three-Dimensional Single-Molecule Localization Microscopy in Whole-Cell and Tissue Specimens.

Annu Rev Biomed Eng 2020 Jun 3;22:155-184. Epub 2020 Apr 3.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA; email:

Super-resolution microscopy techniques are versatile and powerful tools for visualizing organelle structures, interactions, and protein functions in biomedical research. However, whole-cell and tissue specimens challenge the achievable resolution and depth of nanoscopy methods. We focus on three-dimensional single-molecule localization microscopy and review some of the major roadblocks and developing solutions to resolving thick volumes of cells and tissues at the nanoscale in three dimensions. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052203DOI Listing

Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis.

Annu Rev Biomed Eng 2020 Jun 25;22:231-256. Epub 2020 Mar 25.

Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

In the last two decades, numerous studies have conducted patient-specific computations of blood flow dynamics in cerebral aneurysms and reported correlations between various hemodynamic metrics and aneurysmal disease progression or treatment outcomes. Nevertheless, intra-aneurysmal flow analysis has not been adopted in current clinical practice, and hemodynamic factors usually are not considered in clinical decision making. This review presents the state of the art in cerebral aneurysm imaging and image-based modeling, discussing the advantages and limitations of each approach and focusing on the translational value of hemodynamic analysis. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-092419-061429DOI Listing

Sparse Data-Driven Learning for Effective and Efficient Biomedical Image Segmentation.

Annu Rev Biomed Eng 2020 Jun 13;22:127-153. Epub 2020 Mar 13.

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut 06520, USA; email:

Sparsity is a powerful concept to exploit for high-dimensional machine learning and associated representational and computational efficiency. Sparsity is well suited for medical image segmentation. We present a selection of techniques that incorporate sparsity, including strategies based on dictionary learning and deep learning, that are aimed at medical image segmentation and related quantification. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052147DOI Listing

Transgenic and Diet-Enhanced Silk Production for Reinforced Biomaterials: A Metamaterial Perspective.

Annu Rev Biomed Eng 2020 Jun 11;22:79-102. Epub 2020 Mar 11.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.

Silk fibers, which are protein-based biopolymers produced by spiders and silkworms, are fascinating biomaterials that have been extensively studied for numerous biomedical applications. Silk fibers often have remarkable physical and biological properties that typical synthetic materials do not exhibit. These attributes have prompted a wide variety of silk research, including genetic engineering, biotechnological synthesis, and bioinspired fiber spinning, to produce silk proteins on a large scale and to further enhance their properties. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-082719-032747DOI Listing

4D Flow with MRI.

Annu Rev Biomed Eng 2020 Jun 10;22:103-126. Epub 2020 Mar 10.

Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA; email:

Magnetic resonance imaging (MRI) has become an important tool for the clinical evaluation of patients with cardiac and vascular diseases. Since its introduction in the late 1980s, quantitative flow imaging with MRI has become a routine part of standard-of-care cardiothoracic and vascular MRI for the assessment of pathological changes in blood flow in patients with cardiovascular disease. More recently, time-resolved flow imaging with velocity encoding along all three flow directions and three-dimensional (3D) anatomic coverage (4D flow MRI) has been developed and applied to enable comprehensive 3D visualization and quantification of hemodynamics throughout the human circulatory system. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-100219-110055DOI Listing

The New Age of Cell-Free Biology.

Annu Rev Biomed Eng 2020 Jun 9;22:51-77. Epub 2020 Mar 9.

Departments of Mechanical Engineering, Biomedical Engineering, Biophysics, and the Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109, USA; email:

The cell-free molecular synthesis of biochemical systems is a rapidly growing field of research. Advances in the Human Genome Project, DNA synthesis, and other technologies have allowed the in vitro construction of biochemical systems, termed cell-free biology, to emerge as an exciting domain of bioengineering. Cell-free biology ranges from the molecular to the cell-population scales, using an ever-expanding variety of experimental platforms and toolboxes. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-092019-111110DOI Listing

Swine Disease Models for Optimal Vascular Engineering.

Annu Rev Biomed Eng 2020 Jun 2;22:25-49. Epub 2020 Mar 2.

Division of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Research Center, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.

Swine disease models are essential for mimicry of human metabolic and vascular pathophysiology, thereby enabling high-fidelity translation to human medicine. The worldwide epidemic of obesity, metabolic disease, and diabetes has prompted the focus on these diseases in this review. We highlight the remarkable similarity between Ossabaw miniature swine and humans with metabolic syndrome and atherosclerosis. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-082919-053009DOI Listing

Layer-by-Layer Biomaterials for Drug Delivery.

Annu Rev Biomed Eng 2020 Jun 21;22:1-24. Epub 2020 Feb 21.

School of Engineering and Center for Biomedical Engineering, Brown University, Providence, Rhode Island 02912, USA; email:

Controlled drug delivery formulations have revolutionized treatments for a range of health conditions. Over decades of innovation, layer-by-layer (LbL) self-assembly has emerged as one of the most versatile fabrication methods used to develop multifunctional controlled drug release coatings. The numerous advantages of LbL include its ability to incorporate and preserve biological activity of therapeutic agents; coat multiple substrates of all scales (e. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052350DOI Listing

Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018.

Annu Rev Biomed Eng 2019 06;21:33-60

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

Our review in the 2008 volume of this journal detailed the use of mechanical circulatory support (MCS) for treatment of heart failure (HF). MCS initially utilized bladder-based blood pumps generating pulsatile flow; these pulsatile flow pumps have been supplanted by rotary blood pumps, in which cardiac support is generated via the high-speed rotation of computationally designed blading. Different rotary pump designs have been evaluated for their safety, performance, and efficacy in clinical trials both in the United States and internationally. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121120DOI Listing
June 2019
30 Reads

Biomaterials: Been There, Done That, and Evolving into the Future.

Authors:
Buddy D Ratner

Annu Rev Biomed Eng 2019 06;21:171-191

Departments of Bioengineering and Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.

Biomaterials as we know them today had their origins in the late 1940s with off-the-shelf commercial polymers and metals. The evolution of materials for medical applications from these simple origins has been rapid and impactful. This review relates some of the early history; addresses concerns after two decades of development in the twenty-first century; and discusses how advanced technologies in both materials science and biology will address concerns, advance materials used at the biointerface, and improve outcomes for patients. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-120940DOI Listing
June 2019
1 Read

A Contemporary Look at Biomechanical Models of Myocardium.

Annu Rev Biomed Eng 2019 06;21:417-442

James T. Willerson Center for Cardiovascular Modeling and Simulation, Oden Institute for Computational Engineering and Sciences, and Department of Biomedical Engineering, University of Texas, Austin, Texas 78712, USA; email:

Understanding and predicting the mechanical behavior of myocardium under healthy and pathophysiological conditions are vital to developing novel cardiac therapies and promoting personalized interventions. Within the past 30 years, various constitutive models have been proposed for the passive mechanical behavior of myocardium. These models cover a broad range of mathematical forms, microstructural observations, and specific test conditions to which they are fitted. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626320PMC
June 2019
1 Read

Human Positron Emission Tomography Neuroimaging.

Annu Rev Biomed Eng 2019 06;21:551-581

Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut 06520, USA; email:

Neuroimaging with positron emission tomography (PET) is the most powerful tool for understanding pharmacology, neurochemistry, and pathology in the living human brain. This technology combines high-resolution scanners to measure radioactivity throughout the human body with specific, targeted radioactive molecules, which allow measurements of a myriad of biological processes in vivo While PET brain imaging has been active for almost 40 years, the pace of development for neuroimaging tools, known as radiotracers, and for quantitative analytical techniques has increased dramatically over the past decade. Accordingly, the fundamental questions that can be addressed with PET have expanded in basic neurobiology, psychiatry, neurology, and related therapeutic development. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121056DOI Listing
June 2019
18 Reads

Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis.

Annu Rev Biomed Eng 2019 06;21:267-297

Laboratory of Applied Mechanobiology, Institute of Translational Medicine, and Department of Health Sciences and Technology, ETH Zurich, CH-8093 Zurich, Switzerland; email:

In addition to their early-recognized functions in host defense and the clearance of apoptotic cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If misregulated, they steer the progression of many inflammatory diseases. Much progress has been made in understanding the mechanisms underlying macrophage signaling, transcriptomics, and proteomics, under physiological and pathological conditions. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121224DOI Listing
June 2019
2 Reads

New Sensor and Wearable Technologies to Aid in the Diagnosis and Treatment Monitoring of Parkinson's Disease.

Annu Rev Biomed Eng 2019 06;21:111-143

HM CINAC, Hospital Universitario HM Puerta del Sur, Universidad CEU-San Pablo, 28938 Móstoles, Madrid, Spain; email: , , ,

Parkinson's disease (PD) is a degenerative disorder of the brain characterized by the impairment of the nigrostriatal system. This impairment leads to specific motor manifestations (i.e. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121036DOI Listing
June 2019
15 Reads

Controlling Matter at the Molecular Scale with DNA Circuits.

Annu Rev Biomed Eng 2019 06;21:469-493

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.

In recent years, a diverse set of mechanisms have been developed that allow DNA strands with specific sequences to sense information in their environment and to control material assembly, disassembly, and reconfiguration. These sequences could serve as the inputs and outputs for DNA computing circuits, enabling DNA circuits to act as chemical information processors to program complex behavior in chemical and material systems. This review describes processes that can be sensed and controlled within such a paradigm. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052357DOI Listing
June 2019
11 Reads

Intracranial Pressure and Intracranial Elastance Monitoring in Neurocritical Care.

Annu Rev Biomed Eng 2019 06;21:523-549

Neuroscience Intensive Care Unit, Department of Anesthesia and Critical Care, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy; email: ,

Patients with acute brain injuries tend to be physiologically unstable and at risk of rapid and potentially life-threatening decompensation due to shifts in intracranial compartment volumes and consequent intracranial hypertension. Invasive intracranial pressure (ICP) monitoring therefore remains a cornerstone of modern neurocritical care, despite the attendant risks of infection and damage to brain tissue arising from the surgical placement of a catheter or pressure transducer into the cerebrospinal fluid or brain tissue compartments. In addition to ICP monitoring, tracking of the intracranial capacity to buffer shifts in compartment volumes would help in the assessment of patient state, inform clinical decision making, and guide therapeutic interventions. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052257DOI Listing
June 2019
2 Reads

Digital Manufacturing for Microfluidics.

Annu Rev Biomed Eng 2019 06;21:325-364

Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA; email:

The microfluidics field is at a critical crossroads. The vast majority of microfluidic devices are presently manufactured using micromolding processes that work very well for a reduced set of biocompatible materials, but the time, cost, and design constraints of micromolding hinder the commercialization of many devices. As a result, the dissemination of microfluidic technology-and its impact on society-is in jeopardy. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-092618-020341DOI Listing
June 2019
1 Read

Challenges and Opportunities in the Design of Liver-on-Chip Microdevices.

Annu Rev Biomed Eng 2019 06;21:219-239

Grass Center for Bioengineering, Benin School of Computer Science and Engineering, Hebrew University of Jerusalem, Jerusalem 91904, Israel.

The liver is the central hub of xenobiotic metabolism and consequently the organ most prone to cosmetic- and drug-induced toxicity. Failure to detect liver toxicity or to assess compound clearance during product development is a major cause of postmarketing product withdrawal, with disastrous clinical and financial consequences. While small animals are still the preferred model in drug development, the recent ban on animal use in the European Union created a pressing need to develop precise and efficient tools to detect human liver toxicity during cosmetic development. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004816PMC
June 2019
7 Reads

The Meniscus in Normal and Osteoarthritic Tissues: Facing the Structure Property Challenges and Current Treatment Trends.

Annu Rev Biomed Eng 2019 06 8;21:495-521. Epub 2019 Apr 8.

Stokes Laboratories, Bernal Institute, School of Engineering, University of Limerick, Limerick V94 PC82, Ireland; email:

The treatment of meniscus injuries has recently been facing a paradigm shift toward the field of tissue engineering, with the aim of regenerating damaged and diseased menisci as opposed to current treatment techniques. This review focuses on the structure and mechanics associated with the meniscus. The meniscus is defined in terms of its biological structure and composition. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052547DOI Listing
June 2019
16 Reads

The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease.

Annu Rev Biomed Eng 2019 06 27;21:443-468. Epub 2019 Mar 27.

Meinig School of Biomedical Engineering and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, USA; email: ,

Cellular behavior is continuously affected by microenvironmental forces through the process of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical responses. Mounting evidence suggests that the nucleus itself is a mechanoresponsive element, reacting to cytoskeletal forces and mediating downstream biochemical responses. The nucleus responds through a host of mechanisms, including partial unfolding, conformational changes, and phosphorylation of nuclear envelope proteins; modulation of nuclear import/export; and altered chromatin organization, resulting in transcriptional changes. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815102PMC
June 2019
1 Read

Frontiers in Cryo Electron Microscopy of Complex Macromolecular Assemblies.

Annu Rev Biomed Eng 2019 06 20;21:395-415. Epub 2019 Mar 20.

University of British Columbia, Vancouver, British Columbia V6T 1Z2, Canada; email:

In recent years, cryo electron microscopy (cryo-EM) technology has been transformed with the development of better instrumentation, direct electron detectors, improved methods for specimen preparation, and improved software for data analysis. Analyses using single-particle cryo-EM methods have enabled determination of structures of proteins with sizes smaller than 100 kDa and resolutions of ∼2 Å in some cases. The use of electron tomography combined with subvolume averaging is beginning to allow the visualization of macromolecular complexes in their native environment in unprecedented detail. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052453DOI Listing
June 2019
1 Read

Skin-Mountable Biosensors and Therapeutics: A Review.

Annu Rev Biomed Eng 2019 06 18;21:299-323. Epub 2019 Mar 18.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA; email:

Miniaturization of electronic components and advances in flexible and stretchable materials have stimulated the development of wearable health care systems that can reflect and monitor personal health status by health care professionals. New skin-mountable devices that offer seamless contact onto the human skin, even under large deformations by natural motions of the wearer, provide a route for both high-fidelity monitoring and patient-controlled therapy. This article provides an overview of several important aspects of skin-mountable devices and their applications in many medical settings and clinical practices. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052315DOI Listing
June 2019
4 Reads

Single-Cell Omics Analyses Enabled by Microchip Technologies.

Annu Rev Biomed Eng 2019 06 18;21:365-393. Epub 2019 Mar 18.

Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA; email: , ,

Single-cell omics studies provide unique information regarding cellular heterogeneity at various levels of the molecular biology central dogma. This knowledge facilitates a deeper understanding of how underlying molecular and architectural changes alter cell behavior, development, and disease processes. The emerging microchip-based tools for single-cell omics analysis are enabling the evaluation of cellular omics with high throughput, improved sensitivity, and reduced cost. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052538DOI Listing
June 2019
1 Read

Programming Stimuli-Responsive Behavior into Biomaterials.

Annu Rev Biomed Eng 2019 06 11;21:241-265. Epub 2019 Mar 11.

Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA; email:

Stimuli-responsive materials undergo triggered changes when presented with specific environmental cues. These dynamic systems can leverage biological signals found locally within the body as well as exogenous cues administered with spatiotemporal control, providing powerful opportunities in next-generation diagnostics and personalized medicine. Here, we review the synthetic and strategic advances used to impart diverse responsiveness to a wide variety of biomaterials. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052324DOI Listing
June 2019
1 Read

Frontiers of Medical Robotics: From Concept to Systems to Clinical Translation.

Annu Rev Biomed Eng 2019 06 1;21:193-218. Epub 2019 Mar 1.

The Hamlyn Centre for Robotic Surgery, Imperial College London, London SW7 2AZ, United Kingdom; email: ,

Medical robotics is poised to transform all aspects of medicine-from surgical intervention to targeted therapy, rehabilitation, and hospital automation. A key area is the development of robots for minimally invasive interventions. This review provides a detailed analysis of the evolution of interventional robots and discusses how the integration of imaging, sensing, and robotics can influence the patient care pathway toward precision intervention and patient-specific treatment. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052502DOI Listing

Hydrogel-Based Strategies to Advance Therapies for Chronic Skin Wounds.

Annu Rev Biomed Eng 2019 06 1;21:145-169. Epub 2019 Mar 1.

3B's Research Group, I3B's: Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, and Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, 4805-017 Barco, Guimarães, Portugal; email: , , ,

Chronic skin wounds are the leading cause of nontraumatic foot amputations worldwide and present a significant risk of morbidity and mortality due to the lack of efficient therapies. The intrinsic characteristics of hydrogels allow them to benefit cutaneous healing essentially by supporting a moist environment. This property has long been explored in wound management to aid in autolytic debridement. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-bioeng-060
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http://dx.doi.org/10.1146/annurev-bioeng-060418-052422DOI Listing
June 2019
24 Reads

The Biocompatibility Challenges in the Total Artificial Heart Evolution.

Annu Rev Biomed Eng 2019 06 22;21:85-110. Epub 2019 Feb 22.

Cardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua and Veneto Institute of Molecular Medicine, 35128 Padua, Italy; email: , ,

There are limited therapeutic options for final treatment of end-stage heart failure. Among them, implantation of a total artificial heart (TAH) is an acceptable strategy when suitable donors are not available. TAH development began in the 1930s, followed by a dramatic evolution of the actuation mechanisms operating the mechanical pumps. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052432DOI Listing
June 2019
1 Read

Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities.

Annu Rev Biomed Eng 2019 06 20;21:61-84. Epub 2019 Feb 20.

Weldon School of Biomedical Engineering and College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA; email:

Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent technologies to combat the current opioid epidemic. These abuse-deterrent formulations (ADFs) are intended to deter physical and chemical tampering of opioid-based products, while still providing safe and effective delivery for therapeutic purposes. Even though formulations with varying abuse-deterrent technologies have been approved, questions remain about their effectiveness. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052155DOI Listing
June 2019
2 Reads

Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation.

Annu Rev Biomed Eng 2019 06 10;21:1-31. Epub 2018 Dec 10.

Center for Engineering in Medicine and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA; email: , ,

Successful stabilization and preservation of biological materials often utilize low temperatures and dehydration to arrest molecular motion. Cryoprotectants are routinely employed to help the biological entities survive the physicochemical and mechanical stresses induced by cold or dryness. Molecular interactions between biomolecules, cryoprotectants, and water fundamentally determine the outcomes of preservation. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-060418-052130DOI Listing
June 2019
1 Read

Energy-Based Tissue Fusion for Sutureless Closure: Applications, Mechanisms, and Potential for Functional Recovery.

Annu Rev Biomed Eng 2018 06;20:1-20

Department of Mechanical Engineering, University of Colorado, Boulder, Colorado 80309, USA; email:

As minimally invasive surgical techniques progress, the demand for efficient, reliable methods for vascular ligation and tissue closure becomes pronounced. The surgical advantages of energy-based vessel sealing exceed those of traditional, compression-based ligatures in procedures sensitive to duration, foreign bodies, and recovery time alike. Although the use of energy-based devices to seal or transect vasculature and connective tissue bundles is widespread, the breadth of heating strategies and energy dosimetry used across devices underscores an uncertainty as to the molecular nature of the sealing mechanism and induced tissue effect. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-071516-044702DOI Listing
June 2018
2 Reads

Platelet Mechanotransduction.

Annu Rev Biomed Eng 2018 06;20:253-275

Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children's Healthcare of Atlanta/Emory University School of Medicine, Atlanta, Georgia 30332, USA; email:

The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand-receptor interactions governing the recruitment, activation, and aggregation of platelets. The physical biology of each step is distinct in that the recruitment of platelets depends on the mechanosensing of the platelet receptor glycoprotein Ib for the adhesive protein von Willebrand factor, whereas platelet activation and aggregation are responsive to the mechanical forces sensed at adhesive junctions between platelets and at the platelet-matrix interface. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121215DOI Listing
June 2018
4 Reads

Bone Mechanical Properties in Healthy and Diseased States.

Annu Rev Biomed Eng 2018 06;20:119-143

Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, Boston, Massachusetts 02215, USA; email:

The mechanical properties of bone are fundamental to the ability of our skeletons to support movement and to provide protection to our vital organs. As such, deterioration in mechanical behavior with aging and/or diseases such as osteoporosis and diabetes can have profound consequences for individuals' quality of life. This article reviews current knowledge of the basic mechanical behavior of bone at length scales ranging from hundreds of nanometers to tens of centimeters. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-bioeng-062
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http://dx.doi.org/10.1146/annurev-bioeng-062117-121139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053074PMC
June 2018
3 Reads

Engineering the Mucus Barrier.

Annu Rev Biomed Eng 2018 06;20:197-220

Department of Chemical Engineering, Northeastern University, Boston, Massachusetts 02115, USA; email:

Mucus selectively controls the transport of molecules, particulate matter, and microorganisms to the underlying epithelial layer. It may be desirable to weaken the mucus barrier to enable effective delivery of drug carriers. Alternatively, the mucus barrier can be strengthened to prevent epithelial interaction with pathogenic microbes or other exogenous materials. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463277PMC
June 2018
1 Read

From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer.

Annu Rev Biomed Eng 2018 06;20:301-327

Department of Biomedical Engineering, University of Texas, Austin, Texas 78712, USA; email:

This review explores bioheat transfer applications at multiple scales from nanoparticle (NP) heating to whole-body thermoregulation. For instance, iron oxide nanoparticles are being used for nanowarming, which uniformly and quickly rewarms 50-80-mL (≤5-cm-diameter) vitrified systems by coupling with radio-frequency (RF) fields where standard convective warming fails. A modification of this approach can also be used to successfully rewarm cryopreserved fish embryos (∼0. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-bioeng-071
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http://dx.doi.org/10.1146/annurev-bioeng-071516-044532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568271PMC
June 2018
9 Reads

Arterial Venous Differentiation for Vascular Bioengineering.

Annu Rev Biomed Eng 2018 06 11;20:431-447. Epub 2018 Apr 11.

Department of Bioengineering, Northeastern University, Boston, Massachusetts 02115, USA; email:

The development processes of arteries and veins are fundamentally different, leading to distinct differences in anatomy, structure, and function as well as molecular profiles. Understanding the complex interaction between genetic and epigenetic pathways, as well as extracellular and biomechanical signals that orchestrate arterial venous differentiation, is not only critical for the understanding of vascular diseases of arteries and veins but also valuable for vascular tissue engineering strategies. Recent research has suggested that certain transcriptional factors not only control arterial venous differentiation during development but also play a critical role in adult vessel function and disease processes. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121231DOI Listing
June 2018
6 Reads

Physiology and Engineering of the Graded Interfaces of Musculoskeletal Junctions.

Annu Rev Biomed Eng 2018 06 11;20:403-429. Epub 2018 Apr 11.

McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, and Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; email:

The connective tissues of the musculoskeletal system can be grouped into fibrous, cartilaginous, and calcified tissues. While each tissue type has a distinct composition and function, the intersections between these tissues result in the formation of complex, composite, and graded junctions. The complexity of these interfaces is a critical aspect of their healthy function, but poses a significant challenge for their repair. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121113DOI Listing
June 2018
2 Reads

Inorganic Nanomaterials for Soft Tissue Repair and Regeneration.

Annu Rev Biomed Eng 2018 06 5;20:353-374. Epub 2018 Apr 5.

Department of Chemical Engineering, Arizona State University, Tempe, Arizona 85287-6106, USA; email:

Inorganic nanomaterials have witnessed significant advances in areas of medicine including cancer therapy, imaging, and drug delivery, but their use in soft tissue repair and regeneration is in its infancy. Metallic, ceramic, and carbon allotrope nanoparticles have shown promise in facilitating tissue repair and regeneration. Inorganic nanomaterials have been employed to improve stem cell engraftment in cellular therapy, material mechanical stability in tissue repair, electrical conductivity in nerve and cardiac regeneration, adhesion strength in tissue approximation, and antibacterial capacity in wound dressings. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-071516-044457DOI Listing
June 2018
2 Reads

Structural DNA Nanotechnology: Artificial Nanostructures for Biomedical Research.

Annu Rev Biomed Eng 2018 06 4;20:375-401. Epub 2018 Apr 4.

School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.

Structural DNA nanotechnology utilizes synthetic or biologic DNA as designer molecules for the self-assembly of artificial nanostructures. The field is founded upon the specific interactions between DNA molecules, known as Watson-Crick base pairing. After decades of active pursuit, DNA has demonstrated unprecedented versatility in constructing artificial nanostructures with significant complexity and programmability. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-120904DOI Listing
June 2018
5 Reads

Circulating Tumor Cells: Diagnostic and Therapeutic Applications.

Annu Rev Biomed Eng 2018 06 14;20:329-352. Epub 2018 Mar 14.

Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA; email:

Metastasis contributes to poor prognosis in many types of cancer and is the leading cause of cancer-related deaths. Tumor cells metastasize to distant sites via the circulatory and lymphatic systems. In this review, we discuss the potential of circulating tumor cells for diagnosis and describe the experimental therapeutics that aim to target these disseminating cancer cells. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-120947DOI Listing
June 2018
7 Reads

Synthetic Biology Approaches to Engineer Probiotics and Members of the Human Microbiota for Biomedical Applications.

Annu Rev Biomed Eng 2018 06 12;20:277-300. Epub 2018 Mar 12.

Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts 02155, USA; email:

An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics that can probe and improve human health. In this review, we discuss recent advances in synthetic biology to engineer commensal and probiotic lactic acid bacteria, bifidobacteria, and Bacteroides for these purposes, and we provide our perspective on the future potential of these technologies. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-121019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100750PMC
June 2018
6 Reads

Advanced Endoscopic Navigation: Surgical Big Data, Methodology, and Applications.

Annu Rev Biomed Eng 2018 06 5;20:221-251. Epub 2018 Mar 5.

Robarts Research Institute, Western University, London, Ontario N6A 3K7, Canada; email:

Interventional endoscopy (e.g., bronchoscopy, colonoscopy, laparoscopy, cystoscopy) is a widely performed procedure that involves either diagnosis of suspicious lesions or guidance for minimally invasive surgery in a variety of organs within the body cavity. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-120917DOI Listing
June 2018
3 Reads

Facet Joints of the Spine: Structure-Function Relationships, Problems and Treatments, and the Potential for Regeneration.

Annu Rev Biomed Eng 2018 06 1;20:145-170. Epub 2018 Mar 1.

Department of Biomedical Engineering, University of California, Irvine, California 92617, USA; email:

The zygapophysial joint, a diarthrodial joint commonly referred to as the facet joint, plays a pivotal role in back pain, a condition that has been a leading cause of global disability since 1990. Along with the intervertebral disc, the facet joint supports spinal motion and aids in spinal stability. Highly susceptible to early development of osteoarthritis, the facet is responsible for a significant amount of pain in the low-back, mid-back, and neck regions. Read More

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http://dx.doi.org/10.1146/annurev-bioeng-062117-120924DOI Listing
June 2018
5 Reads