291 results match your criteria Annual Review Of Analytical Chemistry[Journal]


Functionalized Silicon Electrodes in Electrochemistry.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Apr 14. Epub 2020 Apr 14.

School of Chemistry, Australia Centre for NanoMedicine, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, NSW 2052, Australia; email:

Avoiding the growth of SiO has been an enduring task for the use of silicon as an electrode material in dynamic electrochemistry. This is because electrochemical assays become unstable when the SiO levels change during measurements. Moreover, the silicon electrode can be completely passivated for electron transfer if a thick layer of insulating SiO grows on the surface. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-092506DOI Listing

Single Crystal Electrochemistry as an In-Situ Analytical Characterization Tool.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Apr 3. Epub 2020 Apr 3.

Instituto Universitario de Electroquímica, Universidad de Alicante, E-03690, San Vicente del Raspeig, Alicante, Spain; email:

The electrochemical behavior of platinum single crystal surfaces can be taken as a model response for the interpretation of the activity of heterogeneous electrodes. The cyclic voltammogram of a given platinum electrode can be considered a fingerprint characteristic of the distribution of sites on its surface. We start this review by providing some simple mathematical descriptions of the voltammetric response in the presence of adsorption processes. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115541DOI Listing

Single-Molecule Imaging of Protein Interactions and Dynamics.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Mar 30. Epub 2020 Mar 30.

Beijing National Research Center for Molecular Sciences, CAS Key Laboratory of Molecule Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; email:

Live-cell single-molecule fluorescence imaging has become a powerful analytical tool to investigate cellular processes that are not accessible to conventional biochemical approaches. This has greatly enriched our understanding of the behaviors of single biomolecules in their native environments and their roles in cellular events. Here, we review recent advances in fluorescence-based single-molecule bioimaging of proteins in living cells. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-094308DOI Listing

Lipid Diversity in Cells and Tissue Using Imaging SIMS.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Mar 25. Epub 2020 Mar 25.

Department of Chemistry and Molecular Biology, University of Gothenburg, 41296 Gothenburg, Sweden; email:

Lipids are an important class of biomolecules with many roles within cells and tissue. As targets for study, they present several challenges. They are difficult to label, as many labels lack the specificity to the many different lipid species or the labels maybe larger than the lipids themselves, thus severely perturbing the natural chemical environment. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-103512DOI Listing

Petroleomics: Tools, Challenges, and Developments.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Mar 20. Epub 2020 Mar 20.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; email:

The detailed molecular characterization of petroleum-related samples by mass spectrometry, often referred to as petroleomics, continues to present significant analytical challenges. As a result, petroleomics continues to be a driving force for the development of new ultrahigh resolution instrumentation, experimental methods, and data analysis procedures. Recent advances in ionization, resolving power, and mass accuracy, and the use of separation methods, have allowed for record levels of compositional detail to be obtained for petroleum-related samples. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-091824DOI Listing

NIST Reference Materials: Utility and Future.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Mar 16. Epub 2020 Mar 16.

Special Programs Office, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland 20899-4701, USA.

The National Institute of Standards and Technology (NIST), formerly the National Bureau of Standards, was established by the US Congress in 1901 and charged with establishing a measurement foundation to facilitate US and international commerce. This broad language provides NIST with the ability to establish and implement its programs in response to changes in national needs and priorities. This review traces some of the changes in NIST's reference material programs over time and presents the NIST Material Measurement Laboratory's current approach to promoting accuracy and metrological traceability of chemical measurements and validation of chemical measurement processes. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115314DOI Listing

Electrochemistry of Single-Vesicle Events.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Mar 9. Epub 2020 Mar 9.

Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden; email:

Neuronal transmission relies on electrical signals and the transfer of chemical signals from one neuron to another. Chemical messages are transmitted from presynaptic neurons to neighboring neurons through the triggered fusion of neurotransmitter-filled vesicles with the cell plasma membrane. This process, known as exocytosis, involves the rapid release of neurotransmitter solutions that are detected with high affinity by the post synaptic neuron. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-010032DOI Listing

Lighting Up Live-Cell and In Vivo Central Carbon Metabolism with Genetically Encoded Fluorescent Sensors.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Mar 2. Epub 2020 Mar 2.

Optogenetics and Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Research Unit of Chinese Academy of Medical Sciences, East China University of Science and Technology, Shanghai 200237, China; email:

As the core component of cell metabolism, central carbon metabolism, consisting of glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle converts nutrients into metabolic precursors for biomass and energy to sustain the life of virtually all extant species. The metabolite levels or distributions in central carbon metabolism often change dynamically with cell fates, development, and disease progression. However, traditional biochemical methods require cell lysis, making it challenging to obtain spatiotemporal information about metabolites in living cells and in vivo. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-091306DOI Listing

Evolution of Analytical Sciences in the United States: A Historical Account.

Authors:
Gary D Christian

Annu Rev Anal Chem (Palo Alto Calif) 2020 Mar 2. Epub 2020 Mar 2.

Department of Chemistry, University of Washington, Seattle, Washington 98195-1700, USA; email:

The current teaching and practice of analytical chemistry reflect the evolution of measurement science over time. Qualitative and quantitative measurements can be traced back to prebiblical times, have been important throughout human history, and today are key to the functioning of a modern society. This review is designed to provide a brief overview of the evolution of analytical science and a summary of the evolution, development, and growth of analytical chemistry in the United States, with emphasis on developments up to the mid-twentieth century. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091119-120456DOI Listing

Proteomics of Select Neglected Tropical Diseases.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Feb 28. Epub 2020 Feb 28.

Department of Molecular Medicine and Neurobiology, The Scripps Research Institute, La Jolla, California 92037, USA; email:

Technological advances in mass spectrometry have enabled the extensive identification, characterization, and quantification of proteins in any biological system. In disease processes proteins are often altered in response to external stimuli; therefore, proteomics, the large-scale study of proteins and their functions, represents an invaluable tool for understanding the molecular basis of disease. This review highlights the use of mass spectrometry-based proteomics to study the pathogenesis, etiology, and pathology of several neglected tropical diseases (NTDs), a diverse group of disabling diseases primarily associated with poverty in tropical and subtropical regions of the world. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-093003DOI Listing
February 2020

Making Sharper Peaks for Reverse-Phase Liquid Chromatography of Proteins.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Feb 28. Epub 2020 Feb 28.

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA; email:

Protein separations have gained increasing interest over the past two decades owing to the dramatic growth of proteins as therapeutics and the completion of the Human Genome Project. About every decade, the field of protein high-performance liquid chromatography (HPLC) seems to mature, having reached what appears to be a theoretical limit. But then scientists well versed in the basic principles of HPLC have invented a way around the limit, generating another decade of exciting progress. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115009DOI Listing
February 2020

Three-Dimensional Single Particle Tracking and Its Applications in Confined Environments.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Feb 25. Epub 2020 Feb 25.

Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA; email:

Single particle tracking (SPT) has proven to be a powerful technique in studying molecular dynamics in complicated systems. We review its recent development, including three-dimensional (3D) SPT and its applications in probing nanostructures and molecule-surface interactions that are important to analytical chemical processes. Several frequently used 3D SPT techniques are introduced. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091819-100409DOI Listing
February 2020

Mass Spectrometry of Human Transporters.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Feb 21. Epub 2020 Feb 21.

Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester M13 9PT, United Kingdom; email:

Transporters are key to understanding how an individual will respond a particular dose of a drug. Two patients with similar systemic concentrations may have quite different local concentrations of a drug at the required site. The transporter profile of any individual depends upon a variety of genetic and environmental factors, including genotype, age, and diet status. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091719-024553DOI Listing
February 2020

Emerging Standards and Analytical Science for Nanoenabled Medical Products.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Feb 21. Epub 2020 Feb 21.

Swiss Federal Laboratories for Materials Science and Technology (EMPA), Materials Meet Life Department, CH-9014 St. Gallen, Switzerland.

Development and application of nanotechnology-enabled medical products, including drugs, devices, and in vitro diagnostics, are rapidly expanding in the global marketplace. In this review, the focus is on providing the reader with an introduction to the landscape of commercially available nanotechnology-enabled medical products as well as an overview of the international documentary standards and reference materials that support and facilitate efficient regulatory evaluation and reliable manufacturing of this diverse group of medical products. We describe the materials, test methods, and standards development needs for emerging medical products. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-102216DOI Listing
February 2020

NanoSIMS Imaging and Analysis in Materials Science.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Feb 4. Epub 2020 Feb 4.

Department of Materials, Photon Science Institute, The University of Manchester, Manchester M13 9PL, UK; email:

High-resolution SIMS analysis can be used to explore a wide range of problems in material science and engineering materials, especially when chemical imaging with good spatial resolution (50-100 nm) can be combined with efficient detection of light elements and precise separation of isotopes and isobaric species. Here, applications of the NanoSIMS instrument in the analysis of inorganic materials are reviewed, focusing on areas of current interest in the development of new materials and degradation mechanisms under service conditions. We have chosen examples illustrating NanoSIMS analysis of grain boundary segregation, chemical processes in cracking, and corrosion of nuclear components. Read More

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http://dx.doi.org/10.1146/annurev-anchem-092019-032524DOI Listing
February 2020

Microfluidic Immunoassays for Time-Resolved Measurement of Protein Secretion from Single Cells.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Feb 7. Epub 2020 Feb 7.

Department of Biological Sciences, The University of Tokyo, Tokyo 113-0033, Japan; email:

Measurement of humoral factors secreted from cells has served as an indispensable method to monitor the states of a cell ensemble because humoral factors play crucial roles in cell-cell interaction and aptly reflect the states of individual cells. Although a cell ensemble consisting of a large number of cells has conventionally been the object of such measurements, recent advances in microfluidic technology together with highly sensitive immunoassays have enabled us to quantify secreted humoral factors even from individual cells in either a population or a temporal context. Many groups have reported various miniaturized platforms for immunoassays of proteins secreted from single cells. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-101212DOI Listing
February 2020

Advances in Paper-Based Analytical Devices.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Jan 27. Epub 2020 Jan 27.

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80526, USA; email:

Microfluidic paper-based analytical devices (μPADs) are the newest generation of lab-on-a-chip devices and have made significant strides in both our understanding of fundamental behavior and performance characteristics and expanding their applications. μPADs have become useful analytical techniques for environmental analysis in addition to their more common application as medical point-of-care devices. Although the most common method for device fabrication is wax printing, numerous other techniques exist and have helped address factors ranging from solvent compatibility to improved device function. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114845DOI Listing
January 2020

Clinically Relevant Tissue Scale Responses as New Readouts from Organs-on-a-Chip for Precision Medicine.

Annu Rev Anal Chem (Palo Alto Calif) 2020 Jan 21. Epub 2020 Jan 21.

Department of Biomedical Engineering, Rutgers University, New Jersey 08854, USA.

Organs-on-chips (OOC) are widely seen as being the next generation in vitro models able to accurately recreate the biochemical-physical cues of the cellular microenvironment found in vivo. In addition, they make it possible to examine tissue-scale functional properties of multicellular systems dynamically and in a highly controlled manner. Here we summarize some of the most remarkable examples of OOC technology's ability to extract clinically relevant tissue-level information. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114919DOI Listing
January 2020

Autobiography of an Analytical Chemist.

Authors:
Edward S Yeung

Annu Rev Anal Chem (Palo Alto Calif) 2020 Jan 6. Epub 2020 Jan 6.

Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA; email:

Most of my research directions were opportunistic. Having worked with lasers in the early stages of laser applications in analytical chemistry, attending conferences, workshops, and administrative meetings that were not exactly aligned with our own research, locating to a building or in a department that housed scientists with different backgrounds, having certain specialized equipment at the right time, and having funding agencies that were broad-minded clearly contributed to my ventures into diverse fields. Most of all, it had to be the many eager minds that I have had the fortune to work with. Read More

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http://dx.doi.org/10.1146/annurev-anchem-090519-111018DOI Listing
January 2020

3D Printed Microfluidics.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Dec 10. Epub 2019 Dec 10.

Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA; email:

Traditional microfabrication techniques suffer from several disadvantages, including the inability to create truly three-dimensional (3D) architectures, expensive and time-consuming processes when changing device designs, and difficulty in transitioning from prototyping fabrication to bulk manufacturing. 3D printing is an emerging technique that could overcome these disadvantages. While most 3D printed fluidic devices and features to date have been on the millifluidic size scale, some truly microfluidic devices have been shown. Read More

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http://dx.doi.org/10.1146/annurev-anchem-091619-102649DOI Listing
December 2019

Advanced Spectroelectrochemical Techniques to Study Electrode Interfaces Within Lithium-Ion and Lithium-Oxygen Batteries.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 30;12(1):323-346. Epub 2019 Apr 30.

Department of Chemistry, Stephenson Institute for Renewable Energy, University of Liverpool, Liverpool L69 7ZD, United Kingdom; email:

Lithium battery technologies have revolutionized mobile energy storage, but improvements in the technology are still needed. Critical to delivering new light weight, high capacity, safe devices is an improved understanding of the dynamic processes occurring at the electrode-electrolyte interfaces. Therefore, alongside advances in materials there has been a parallel progression in advanced characterization methods. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115303DOI Listing
June 2019
21 Reads

Single Nanoparticle Electrochemistry.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 24;12(1):347-370. Epub 2019 Apr 24.

School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China; email: ;

Experimental techniques to monitor and visualize the behaviors of single nanoparticles have not only revealed the significant spatial and temporal heterogeneity of those individuals, which are hidden in ensemble methods, but more importantly, they have also enabled researchers to elucidate the origin of such heterogeneity. In pursuing the intrinsic structure-function relations of single nanoparticles, the recently developed stochastic collision approach demonstrated some early promise. However, it was later realized that the appropriate sizing of a single nanoparticle by an electrochemical method could be far more challenging than initially expected owing to the dynamic motion of nanoparticles in electrolytes and complex charge-transfer characteristics at electrode surfaces. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114902DOI Listing
June 2019
4 Reads

Flow Cytometric Analysis of Nanoscale Biological Particles and Organelles.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 12;12(1):389-409. Epub 2019 Apr 12.

MOE Key Laboratory of Spectrochemical Analysis and Instrumentation; Key Laboratory for Chemical Biology of Fujian Province; Collaborative Innovation Center of Chemistry for Energy Material; and Department of Chemical Biology, College of Chemistry and Engineering, Xiamen University, Xiamen, Fujian 361005, China; email:

Analysis of nanoscale biological particles and organelles (BPOs) at the single-particle level is fundamental to the in-depth study of biosciences. Flow cytometry is a versatile technique that has been well-established for the analysis of eukaryotic cells, yet conventional flow cytometry can hardly meet the sensitivity requirement for nanoscale BPOs. Recent advances in high-sensitivity flow cytometry have made it possible to conduct precise, sensitive, and specific analyses of nanoscale BPOs, with exceptional benefits for bacteria, mitochondria, viruses, and extracellular vesicles (EVs). Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115042DOI Listing
June 2019
19 Reads

Single-Cell Protein Secretion Detection and Profiling.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 12;12(1):431-449. Epub 2019 Apr 12.

Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520, USA; email:

Secreted proteins play important roles in mediating various biological processes such as cell-cell communication, differentiation, migration, and homeostasis at the population or tissue level. Here, we review bioanalytical technologies and devices for detecting protein secretions from single cells. We begin by discussing conventional approaches followed by detailing the latest advances in microengineered systems for detecting single-cell protein secretions with an emphasis on multiplex measurement. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-anchem-061
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http://dx.doi.org/10.1146/annurev-anchem-061318-115055DOI Listing
June 2019
14 Reads

Whole-Organism Analysis by Vibrational Spectroscopy.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 12;12(1):89-108. Epub 2019 Apr 12.

School of Chemistry, Monash University, Victoria 3800, Australia; email:

Vibrational spectroscopy has contributed to the understanding of biological materials for many years. As the technology has advanced, the technique has been brought to bear on the analysis of whole organisms. Here, we discuss advanced and recently developed infrared and Raman spectroscopic instrumentation to whole-organism analysis. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115117DOI Listing
June 2019
3 Reads

Emerging Analytical Techniques for Rapid Pathogen Identification and Susceptibility Testing.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 2;12(1):41-67. Epub 2019 Apr 2.

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA; email:

In the face of looming threats from multi-drug resistant microorganisms, there is a growing need for technologies that will enable rapid identification and drug susceptibility profiling of these pathogens in health care settings. In particular, recent progress in microfluidics and nucleic acid amplification is pushing the boundaries of timescale for diagnosing bacterial infections. With a diverse range of techniques and parallel developments in the field of analytical chemistry, an integrative perspective is needed to understand the significance of these developments. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115529DOI Listing
June 2019
5 Reads

Electrochemiluminescence Imaging for Bioanalysis.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 2;12(1):275-295. Epub 2019 Apr 2.

School of Chemistry and Chemical Engineering, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, Jiangsu 210093, China; email:

Electrochemiluminescence (ECL) is a widely used analytical technique with the advantages of high sensitivity and low background signal. The recent and rapid development of electrochemical materials, luminophores, and optical elements significantly increases the ECL signals and, thus, ECL imaging with enhanced spatial and temporal resolutions is realized. Currently, ECL imaging is successfully applied to high-throughput bioanalysis and to visualize the distribution of molecules at single cells. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115226DOI Listing
June 2019
16 Reads

Well-Defined Materials for High-Performance Chromatographic Separation.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 2;12(1):451-473. Epub 2019 Apr 2.

CAS Key Lab of Separation Sciences for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; email:

Chromatographic separation has been widely applied in various fields, such as chemical engineering, precision medicine, energy, and biology. Because chromatographic separation is based on differential partitioning between the mobile phase and stationary phase and affected by band dispersion and mass transfer resistance from these two phases, the materials used as the stationary phase play a decisive role in separation performance. In this review, we discuss the design of separation materials to achieve the separation with high efficiency and high resolution and highlight the well-defined materials with uniform pore structure and unique properties. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114854DOI Listing
June 2019
1 Read

Molecular Characterization of Atmospheric Organic Aerosol by Mass Spectrometry.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 22;12(1):247-274. Epub 2019 Mar 22.

Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA; email:

Atmospheric aerosol, particulate matter suspended in the air we breathe, exerts a strong impact on our health and the environment. Controlling the amount of particulate matter in air is difficult, as there are many ways particles can form by both natural and anthropogenic processes. We gain insight into the sources of particulate matter through chemical composition measurements. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061516-045135DOI Listing
June 2019
1 Read

Challenges in Identifying the Dark Molecules of Life.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 18;12(1):177-199. Epub 2019 Mar 18.

School of Chemistry and Biochemistry, Georgia Institute of Technology and Petit Institute for Biochemistry and Bioscience, Atlanta, Georgia 30332, USA; email:

Metabolomics is the study of the metabolome, the collection of small molecules in living organisms, cells, tissues, and biofluids. Technological advances in mass spectrometry, liquid- and gas-phase separations, nuclear magnetic resonance spectroscopy, and big data analytics have now made it possible to study metabolism at an omics or systems level. The significance of this burgeoning scientific field cannot be overstated: It impacts disciplines ranging from biomedicine to plant science. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716371PMC
June 2019
2 Reads

Recent Developments in Nanosensors for Imaging Applications in Biological Systems.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 11;12(1):109-128. Epub 2019 Mar 11.

Department of Bioengineering, Northeastern University, Boston, Massachusetts 02115, USA; email:

Sensors are key tools for monitoring the dynamic changes of biomolecules and biofunctions that encode valuable information that helps us understand underlying biological processes of fundamental importance. Because of their distinctive size-dependent physicochemical properties, materials with nanometer scales have recently emerged as promising candidates for biological sensing applications by offering unique insights into real-time changes of key physiological parameters. This review focuses on recent advances in imaging-based nanosensor developments and applications categorized by their signal transduction mechanisms, namely, fluorescence, plasmonics, MRI, and photoacoustics. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958676PMC
June 2019
3 Reads

E-Cigarette Chemistry and Analytical Detection.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 8;12(1):23-39. Epub 2019 Mar 8.

Department of Chemistry, Portland State University, Portland, Oregon 97201, USA; email:

The study of e-cigarette aerosol properties can inform public health while longer-term epidemiological investigations are ongoing. The determination of aerosol levels of known toxins, as well as of molecules with unknown inhalation toxicity profiles, affords specific information for estimating the risks of e-cigarettes and for uncovering areas that should be prioritized for further investigation. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565477PMC
June 2019
1 Read

Metabolic Imaging at the Single-Cell Scale: Recent Advances in Mass Spectrometry Imaging.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 8;12(1):201-224. Epub 2019 Mar 8.

National Physical Laboratory, Teddington, Middlesex, TW11 0LW, United Kingdom; email: k.

There is an increasing appreciation that every cell, even of the same type, is different. This complexity, when additionally combined with the variety of different cell types in tissue, is driving the need for spatially resolved omics at the single-cell scale. Rapid advances are being made in genomics and transcriptomics, but progress in metabolomics lags. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-anchem-061
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http://dx.doi.org/10.1146/annurev-anchem-061318-115516DOI Listing
June 2019
33 Reads

Advances in Surface Plasmon Resonance Imaging and Microscopy and Their Biological Applications.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 1;12(1):151-176. Epub 2019 Mar 1.

Institute of Photonics and Electronics, Czech Academy of Sciences, 18251 Prague, Czech Republic; email:

Surface plasmon resonance microscopy and imaging are optical methods that enable observation and quantification of interactions of nano- and microscale objects near a metal surface in a temporally and spatially resolved manner. This review describes the principles of surface plasmon resonance microscopy and imaging and discusses recent advances in these methods, in particular, in optical platforms and functional coatings. In addition, the biological applications of these methods are reviewed. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115106DOI Listing
June 2019
2 Reads

Polyvalent Nanoobjects for Precision Diagnostics.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 27;12(1):69-88. Epub 2019 Feb 27.

Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, USA; email:

As our ability to synthesize and modify nanoobjects has improved, efforts to explore nanotechnology for diagnostic purposes have gained momentum. The variety of nanoobjects, especially those with polyvalent properties, displays a wide range of practical and unique properties well suited for applications in various diagnostics. This review briefly covers the broad scope of multivalent nanoobjects and their use in diagnostics, ranging from ex vivo assays and biosensors to in vivo imaging. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114938DOI Listing
June 2019
2 Reads

Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 20;12(1):129-150. Epub 2019 Feb 20.

Center for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, and Department of Chemistry, University of Virginia, Charlottesville, Virginia 22908, USA; email:

Although fluorescent reporters and biosensors have become indispensable tools in biological and biomedical fields, fluorescence measurements require external excitation light, thereby limiting their use in thick tissues and live animals. Bioluminescent reporters and biosensors may potentially overcome this hurdle because they use enzyme-catalyzed exothermic biochemical reactions to generate excited-state emitters. This review first introduces the development of bioluminescent reporters, and next, their applications in sensing biological changes in vitro and in vivo as biosensors. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565457PMC
June 2019
1 Read

Laser Desorption Combined with Laser Postionization for Mass Spectrometry.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 20;12(1):225-245. Epub 2019 Feb 20.

Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, USA; email:

Lasers with pulse lengths from nanoseconds to femtoseconds and wavelengths from the mid-infrared to extreme ultraviolet (UV) have been used for desorption or ablation in mass spectrometry. Such laser sampling can often benefit from the addition of a second laser for postionization of neutrals. The advantages offered by laser postionization include the ability to forego matrix application, high lateral resolution, decoupling of ionization from desorption, improved analysis of electrically insulating samples, and potential for high sensitivity and depth profiling while minimizing differential detection. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115447DOI Listing
June 2019
1 Read

Wearable Sensors for Biochemical Sweat Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 20;12(1):1-22. Epub 2019 Feb 20.

Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; email:

Sweat is a largely unexplored biofluid that contains many important biomarkers ranging from electrolytes and metabolites to proteins, cytokines, antigens, and exogenous drugs. The eccrine and apocrine glands produce and excrete sweat through microscale pores on the epidermal surface, offering a noninvasive means for capturing and probing biomarkers that reflect hydration state, fatigue, nutrition, and physiological changes. Recent advances in skin-interfaced wearable sensors capable of real-time in situ sweat collection and analytics provide capabilities for continuous biochemical monitoring in an ambulatory mode of operation. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114910DOI Listing
June 2019
1 Read

Single-Molecule Analysis with Solid-State Nanopores.

Authors:
Tim Albrecht

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 1;12(1):371-387. Epub 2019 Feb 1.

School of Chemistry, University of Birmingham, Birmingham B15 2TT, United Kingdom; email:

Solid-state nanopores and nanopipettes are an exciting class of single-molecule sensors that has grown enormously over the last two decades. They offer a platform for testing fundamental concepts of stochasticity and transport at the nanoscale, for studying single-molecule biophysics and, increasingly, also for new analytical applications and in biomedical sensing. This review covers some fundamental aspects underpinning sensor operation and transport and, at the same time, it aims to put these into context as an analytical technique. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125903DOI Listing
June 2019
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Electrochemistry at the Synapse.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 1;12(1):297-321. Epub 2019 Feb 1.

Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901, USA; email:

Electrochemical measurements of neurotransmitters provide insight into the dynamics of neurotransmission. In this review, we describe the development of electrochemical measurements of neurotransmitters and how they started with extrasynaptic measurements but now are pushing toward synaptic measurements. Traditionally, biosensors or fast-scan cyclic voltammetry have monitored extrasynaptic levels of neurotransmitters, such as dopamine, serotonin, adenosine, glutamate, and acetylcholine. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989097PMC
June 2019
3 Reads

Separation Phenomena in Tailored Micro- and Nanofluidic Environments.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 30;12(1):475-500. Epub 2019 Jan 30.

School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, USA; email:

Separations of bioanalytes require robust, effective, and selective migration phenomena. However, due to the complexity of biological matrices such as body fluids or tissue, these requirements are difficult to achieve. The separations field is thus constantly evolving to develop suitable methods to separate biomarkers and fractionate biospecimens for further interrogation of biomolecular content. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125758DOI Listing
June 2019
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Solving the Structure and Dynamics of Metal Nanoparticles by Combining X-Ray Absorption Fine Structure Spectroscopy and Atomistic Structure Simulations.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 30;12(1):501-522. Epub 2019 Jan 30.

Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York 11794, USA; email:

Extended X-ray absorption fine structure (EXAFS) spectroscopy is a premiere method for analysis of the structure and structural transformation of nanoparticles. Extraction of analytical information about the three-dimensional structure and dynamics of metal-metal bonds from EXAFS spectra requires special care due to their markedly non-bulk-like character. In recent decades, significant progress has been made in the first-principles modeling of structure and properties of nanoparticles. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114929DOI Listing
June 2019
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Imaging and Analytics on the Helium Ion Microscope.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 30;12(1):523-543. Epub 2019 Jan 30.

Advanced Instrumentation for Ion Nano-Analytics (AINA), MRT Department, Luxembourg Institute of Science and Technology (LIST), L-4422 Belvaux, Luxembourg; email:

The helium ion microscope (HIM) has emerged as an instrument of choice for patterning, imaging and, more recently, analytics at the nanoscale. Here, we review secondary electron imaging on the HIM and the various methodologies and hardware components that have been developed to confer analytical capabilities to the HIM. Secondary electron-based imaging can be performed at resolutions down to 0. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115457DOI Listing
June 2019
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High-Parameter Single-Cell Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2019 06 30;12(1):411-430. Epub 2019 Jan 30.

Precision Immunology Laboratory, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, USA; email:

Thousands of transcripts and proteins confer function and discriminate cell types in the body. Using high-parameter technologies, we can now measure many of these markers at once, and multiple platforms are now capable of analysis on a cell-by-cell basis. Three high-parameter single-cell technologies have particular potential for discovering new biomarkers, revealing disease mechanisms, and increasing our fundamental understanding of cell biology. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125927DOI Listing
June 2019
2 Reads

Recent Advances and Trends in Microfluidic Platforms for C. elegans Biological Assays.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):245-264

Interdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Microfluidics has proven to be a key tool in quantitative biological research. The C. elegans research community in particular has developed a variety of microfluidic platforms to investigate sensory systems, development, aging, and physiology of the nematode. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125604DOI Listing
June 2018
4 Reads

DNA Electrochemistry and Electrochemical Sensors for Nucleic Acids.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):197-218

Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark; email:

Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other approaches for NA detection. Here, electrode reactions of DNA, basic principles of electrochemical NA analysis, and their relevance for practical applications are reviewed and critically discussed. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125811DOI Listing
June 2018
2 Reads

Mass Spectrometry for Synthesis and Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):1-28

Department of Chemistry, Purdue University, West Lafayette, Indiana 47906, USA; email:

Mass spectrometry is the science and technology of ions. As such, it is concerned with generating ions, measuring their properties, following their reactions, isolating them, and using them to build and transform materials. Instrumentation is an essential element of these activities, and analytical applications are one driving force. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125820DOI Listing
June 2018
3 Reads

Fabrication and Use of Nanopipettes in Chemical Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):265-286

Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; email:

This review summarizes progress in the fabrication, modification, characterization, and applications of nanopipettes since 2010. A brief history of nanopipettes is introduced, and the details of fabrication, modification, and characterization of nanopipettes are provided. Applications of nanopipettes in chemical analysis are the focus in several cases, including recent progress in imaging; in the study of single molecules, single nanoparticles, and single cells; in fundamental investigations of charge transfer (ion and electron) reactions at liquid/liquid interfaces; and as hyphenated techniques combined with other methods to study the mechanisms of complicated electrochemical reactions and to conduct bioanalysis. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125840DOI Listing
June 2018
5 Reads

Relative and Absolute Quantitation in Mass Spectrometry-Based Proteomics.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):49-77

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA; email:

Mass spectrometry-based quantitative proteomics is a powerful tool for gaining insights into function and dynamics of biological systems. However, peptides with different sequences have different ionization efficiencies, and their intensities in a mass spectrum are not correlated with their abundances. Therefore, various label-free or stable isotope label-based quantitation methods have emerged to assist mass spectrometry to perform comparative proteomic experiments, thus enabling nonbiased identification of thousands of proteins differentially expressed in healthy versus diseased cells. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061516-045357DOI Listing
June 2018
1 Read

Single-Molecule Force Spectroscopy of Transmembrane β-Barrel Proteins.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):375-395

Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland; email:

Single-molecule force spectroscopy (SMFS) has been widely applied to study the mechanical unfolding and folding of transmembrane proteins. Here, we review the recent progress in characterizing bacterial and human transmembrane β-barrel proteins by SMFS. First, we describe the mechanical unfolding of transmembrane β-barrels, which follows a general mechanism dictated by the sequential unfolding and extraction of individual β-strands and β-hairpins from membranes. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-anchem-061
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http://dx.doi.org/10.1146/annurev-anchem-061417-010055DOI Listing
June 2018
15 Reads