269 results match your criteria Annual Review Of Analytical Chemistry[Journal]


Flow Cytometric Analysis of Nanoscale Biological Particles and Organelles.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Apr 12. Epub 2019 Apr 12.

MOE Key Laboratory of Spectrochemical Analysis and Instrumentation; Key Laboratory for Chemical Biology of Fujian Province; Collaborative Innovation Center of Chemistry for Energy Material; and Department of Chemical Biology, College of Chemistry and Engineering, Xiamen University, Xiamen, Fujian 361005, China; email:

Analysis of nanoscale biological particles and organelles (BPOs) at the single-particle level is fundamental to the in-depth study of biosciences. Flow cytometry is a versatile technique that has been well-established for the analysis of eukaryotic cells, yet conventional flow cytometry can hardly meet the sensitivity requirement for nanoscale BPOs. Recent advances in high-sensitivity flow cytometry have made it possible to conduct precise, sensitive, and specific analyses of nanoscale BPOs, with exceptional benefits for bacteria, mitochondria, viruses, and extracellular vesicles (EVs). Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115042DOI Listing

Single-Cell Protein Secretion Detection and Profiling.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Apr 12. Epub 2019 Apr 12.

Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520, USA; email:

Secreted proteins play important roles in mediating various biological processes such as cell-cell communication, differentiation, migration, and homeostasis at the population or tissue level. Here, we review bioanalytical technologies and devices for detecting protein secretions from single cells. We begin by discussing conventional approaches followed by detailing the latest advances in microengineered systems for detecting single-cell protein secretions with an emphasis on multiplex measurement. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-anchem-061
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http://dx.doi.org/10.1146/annurev-anchem-061318-115055DOI Listing
April 2019
1 Read

Whole-Organism Analysis by Vibrational Spectroscopy.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Apr 12. Epub 2019 Apr 12.

School of Chemistry, Monash University, Victoria 3800, Australia; email:

Vibrational spectroscopy has contributed to the understanding of biological materials for many years. As the technology has advanced, the technique has been brought to bear on the analysis of whole organisms. Here, we discuss advanced and recently developed infrared and Raman spectroscopic instrumentation to whole organism analysis. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115117DOI Listing

Emerging Analytical Techniques for Rapid Pathogen Identification and Susceptibility Testing.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Apr 2. Epub 2019 Apr 2.

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA; email:

In the face of looming threats from multi-drug resistant microorganisms, there is a growing need for technologies that will enable rapid identification and drug susceptibility profiling of these pathogens in health care settings. In particular, recent progress in microfluidics and nucleic acid amplification is pushing the boundaries of timescale for diagnosing bacterial infections. With a diverse range of techniques and parallel developments in the field of analytical chemistry, an integrative perspective is needed to understand the significance of these developments. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115529DOI Listing
April 2019
1 Read

Electrochemiluminescence Imaging for Bioanalysis.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Apr 2. Epub 2019 Apr 2.

School of Chemistry and Chemical Engineering, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, Jiangsu 210093, China; email:

Electrochemiluminescence (ECL) is a widely used analytical technique with the advantages of high sensitivity and low background signal. The recent and rapid development of electrochemical materials, luminophores, and optical elements significantly increases the ECL signals and, thus, ECL imaging with enhanced spatial and temporal resolutions is realized. Currently, ECL imaging is successfully applied to high-throughput bioanalysis and to visualize the distribution of molecules at single cells. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115226DOI Listing
April 2019
1 Read

Well-Defined Materials for High-Performance Chromatographic Separation.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Apr 2. Epub 2019 Apr 2.

CAS Key Lab of Separation Sciences for Analytical Chemistry, National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; email:

Chromatographic separation has been widely applied in the various fields, such as chemical engineering, precision medicine, energy, and biology. Because chromatographic separation is based on differential partitioning between the mobile phase and stationary phase and affected by band dispersion and mass transfer resistance from these two phases, the materials used as the stationary phase play a decisive role in separation performance. In this review, we discuss the design of separation materials to achieve the separation with high efficiency and high resolution and highlight the well-defined materials with uniform pore structure and unique properties. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114854DOI Listing

Molecular Characterization of Atmospheric Organic Aerosol by Mass Spectrometry.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Mar 22. Epub 2019 Mar 22.

Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA; email:

Atmospheric aerosol, particulate matter suspended in the air we breathe, exerts a strong impact on our health and the environment. Controlling the amount of particulate matter in air is difficult, as there are many ways particles can form by both natural and anthropogenic processes. We gain insight into the sources of particulate matter through chemical composition measurements. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061516-045135DOI Listing

Challenges in Identifying the Dark Molecules of Life.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Mar 18. Epub 2019 Mar 18.

School of Chemistry and Biochemistry, Georgia Institute of Technology and Petit Institute for Biochemistry and Bioscience, Atlanta, Georgia 30332, USA; email:

Metabolomics is the study of the metabolome, the collection of small molecules in living organisms, cells, tissues, and biofluids. Technological advances in mass spectrometry, liquid- and gas-phase separations, nuclear magnetic resonance spectroscopy, and big data analytics have now made it possible to study metabolism at an omics or systems level. The significance of this burgeoning scientific field cannot be overstated: It impacts disciplines ranging from biomedicine to plant science. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114959DOI Listing
March 2019
1 Read

Recent Developments in Nanosensors for Imaging Applications in Biological Systems.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Mar 11. Epub 2019 Mar 11.

Department of Bioengineering, Northeastern University, Boston, Massachusetts 02115, USA; email:

Sensors are key tools for monitoring the dynamic changes of biomolecules and biofunctions that encode valuable information that helps us understand underlying biological processes of fundamental importance. Because of their distinctive size-dependent physicochemical properties, materials with nanometer scales have recently emerged as promising candidates for biological sensing applications by offering unique insights into real-time changes of key physiological parameters. This review focuses on recent advances in imaging-based nanosensor developments and applications categorized by their signal transduction mechanisms, namely, fluorescence, plasmonics, MRI, and photoacoustics. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125747DOI Listing

E-Cigarette Chemistry and Analytical Detection.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Mar 8. Epub 2019 Mar 8.

Department of Chemistry, Portland State University, Portland, Oregon 97201, USA; email:

The study of e-cigarette aerosol properties can inform public health while longer-term epidemiological investigations are ongoing. The determination of aerosol levels of known toxins, as well as of molecules with unknown inhalation toxicity profiles, affords specific information for estimating the risks of e-cigarettes and for uncovering areas that should be prioritized for further investigation. Expected final online publication date for the Annual Review of Analytical Chemistry Volume 12 is June 12, 2019. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115329DOI Listing

Metabolic Imaging at the Single-Cell Scale: Recent Advances in Mass Spectrometry Imaging.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Mar 8. Epub 2019 Mar 8.

National Physical Laboratory, Teddington, Middlesex, TW11 0LW, United Kingdom; email: k.

There is an increasing appreciation that every cell, even of the same type, is different. This complexity, when additionally combined with the variety of different cell types in tissue, is driving the need for spatially resolved omics at the single-cell scale. Rapid advances are being made in genomics and transcriptomics, but progress in metabolomics lags. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-anchem-061
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http://dx.doi.org/10.1146/annurev-anchem-061318-115516DOI Listing
March 2019
10 Reads

Advances in Surface Plasmon Resonance Imaging and Microscopy and Their Biological Applications.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Mar 1. Epub 2019 Mar 1.

Institute of Photonics and Electronics, Czech Academy of Sciences, 18251 Prague, Czech Republic; email:

Surface plasmon resonance microscopy and imaging are optical methods that enable observation and quantification of interactions of nano- and microscale objects near a metal surface in a temporally and spatially resolved manner. This review describes the principles of surface plasmon resonance microscopy and imaging and discusses recent advances in these methods, in particular, in optical platforms and functional coatings. In addition, the biological applications of these methods are reviewed. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115106DOI Listing

Polyvalent Nanoobjects for Precision Diagnostics.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 27. Epub 2019 Feb 27.

Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, USA; email:

As our ability to synthesize and modify nanoobjects has improved, efforts to explore nanotechnology for diagnostic purposes have gained momentum. The variety of nanoobjects, especially those with polyvalent properties, displays a wide range of practical and unique properties well suited for applications in various diagnostics. This review briefly covers the broad scope of multivalent nanoobjects and their use in diagnostics, ranging from ex vivo assays and biosensors to in vivo imaging. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114938DOI Listing
February 2019

Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 20. Epub 2019 Feb 20.

Center for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, and Department of Chemistry, University of Virginia, Charlottesville, Virginia 22908, USA; email:

Although fluorescent reporters and biosensors have become indispensable tools in biological and biomedical fields, fluorescence measurements require external excitation light, thereby limiting their use in thick tissues and live animals. Bioluminescent reporters and biosensors may potentially overcome this hurdle because they use enzyme-catalyzed exothermic biochemical reactions to generate excited-state emitters. This review first introduces the development of bioluminescent reporters, and next, their applications in sensing biological changes in vitro and in vivo as biosensors. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115027DOI Listing
February 2019

Laser Desorption Combined with Laser Postionization for Mass Spectrometry.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 20. Epub 2019 Feb 20.

Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607, USA; email:

Lasers with pulse lengths from nanoseconds to femtoseconds and wavelengths from the mid-infrared to extreme ultraviolet (UV) have been used for desorption or ablation in mass spectrometry. Such laser sampling can often benefit from the addition of a second laser for postionization of neutrals. The advantages offered by laser postionization include the ability to forego matrix application, high lateral resolution, decoupling of ionization from desorption, improved analysis of electrically insulating samples, and potential for high sensitivity and depth profiling while minimizing differential detection. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115447DOI Listing
February 2019

Wearable Sensors for Biochemical Sweat Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 20. Epub 2019 Feb 20.

Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; email:

Sweat is a largely unexplored biofluid that contains many important biomarkers ranging from electrolytes and metabolites to proteins, cytokines, antigens, and exogenous drugs. The eccrine and apocrine glands produce and excrete sweat through microscale pores on the epidermal surface, offering a noninvasive means for capturing and probing biomarkers, which reflect hydration state, fatigue, nutrition, and physiological changes. Skin-interfaced wearable sensors capable of real-time in situ sweat collection and analytics provide capabilities for continuous biochemical monitoring in an ambulatory mode of operation. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114910DOI Listing
February 2019

Single-Molecule Analysis with Solid-State Nanopores.

Authors:
Tim Albrecht

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 1. Epub 2019 Feb 1.

School of Chemistry, University of Birmingham, Birmingham B15 2TT, United Kingdom; email:

Solid-state nanopores and nanopipettes are an exciting class of single-molecule sensors that has grown enormously over the last two decades. They offer a platform for testing fundamental concepts of stochasticity and transport at the nanoscale, for studying single-molecule biophysics and, increasingly, also for new analytical applications and in biomedical sensing. This review covers some fundamental aspects underpinning sensor operation and transport and, at the same time, it aims to put these into context as an analytical technique. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125903DOI Listing
February 2019

Electrochemistry at the Synapse.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 1. Epub 2019 Feb 1.

Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901, USA; email:

Electrochemical measurements of neurotransmitters provide insight into the dynamics of neurotransmission. In this review, we describe the development of electrochemical measurements of neurotransmitters and how they started with extrasynaptic measurements but now are pushing toward synaptic measurements. Traditionally, behavioral measurements with biosensors or fast-scan cyclic voltammetry have monitored extrasynaptic levels of neurotransmitters, such as dopamine, serotonin, adenosine, glutamate, and acetylcholine. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115434DOI Listing
February 2019
2 Reads

Separation Phenomena in Tailored Micro- and Nanofluidic Environments.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Jan 30. Epub 2019 Jan 30.

School of Molecular Sciences, Arizona State University, Tempe 85287, Arizona, USA; email:

Separations of bioanalytes require robust, effective, and selective migration phenomena. However, due to the complexity of biological matrices such as body fluids or tissue, these requirements are difficult to achieve. The separations field is thus constantly evolving to develop suitable methods to separate biomarkers and fractionate biospecimens for further interrogation of biomolecular content. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125758DOI Listing
January 2019

Solving the Structure and Dynamics of Metal Nanoparticles by Combining X-Ray Absorption Fine Structure Spectroscopy and Atomistic Structure Simulations.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Jan 30. Epub 2019 Jan 30.

Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York 11794, USA; email:

Extended X-ray absorption fine structure (EXAFS) spectroscopy is a premiere method for analysis of the structure and structural transformation of nanoparticles. Extraction of analytical information about the three-dimensional structure and dynamics of metal-metal bonds from EXAFS spectra requires special care due to their markedly nonbulk-like character. In recent decades, significant progress has been made in the first-principles modeling of structure and properties of nanoparticles. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114929DOI Listing
January 2019

Imaging and Analytics on the Helium Ion Microscope.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Jan 30. Epub 2019 Jan 30.

Advanced Instrumentation for Ion Nano-Analytics (AINA), MRT Department, Luxembourg Institute of Science and Technology (LIST), L-4422 Belvaux, Luxembourg; email:

The helium ion microscope (HIM) has emerged as an instrument of choice for patterning, imaging and, more recently, analytics at the nanoscale. Here, we review secondary electron imaging on the HIM and the various methodologies and hardware components that have been developed to confer analytical capabilities to the HIM. Secondary electron-based imaging can be performed at resolutions down to 0. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115457DOI Listing
January 2019

High-Parameter Single-Cell Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Jan 30. Epub 2019 Jan 30.

Precision Immunology Laboratory, Perlmutter Cancer Center, NYU Langone Health, New York, NY 10016, USA; email:

Thousands of transcripts and proteins confer function and discriminate cell types in the body. Using high-parameter technologies, we can now measure many of these markers at once, and multiple platforms are now capable of analysis on a cell-by-cell basis. Three high-parameter single-cell technologies have particular potential for discovering new biomarkers, revealing disease mechanisms, and increasing our fundamental understanding of cell biology. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125927DOI Listing
January 2019

Recent Advances and Trends in Microfluidic Platforms for C. elegans Biological Assays.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):245-264

Interdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Microfluidics has proven to be a key tool in quantitative biological research. The C. elegans research community in particular has developed a variety of microfluidic platforms to investigate sensory systems, development, aging, and physiology of the nematode. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125604DOI Listing
June 2018
2 Reads

DNA Electrochemistry and Electrochemical Sensors for Nucleic Acids.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):197-218

Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark; email:

Sensitive, specific, and fast analysis of nucleic acids (NAs) is strongly needed in medicine, environmental science, biodefence, and agriculture for the study of bacterial contamination of food and beverages and genetically modified organisms. Electrochemistry offers accurate, simple, inexpensive, and robust tools for the development of such analytical platforms that can successfully compete with other approaches for NA detection. Here, electrode reactions of DNA, basic principles of electrochemical NA analysis, and their relevance for practical applications are reviewed and critically discussed. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125811DOI Listing
June 2018
1 Read

Mass Spectrometry for Synthesis and Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):1-28

Department of Chemistry, Purdue University, West Lafayette, Indiana 47906, USA; email:

Mass spectrometry is the science and technology of ions. As such, it is concerned with generating ions, measuring their properties, following their reactions, isolating them, and using them to build and transform materials. Instrumentation is an essential element of these activities, and analytical applications are one driving force. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125820DOI Listing
June 2018
2 Reads

Fabrication and Use of Nanopipettes in Chemical Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):265-286

Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; email:

This review summarizes progress in the fabrication, modification, characterization, and applications of nanopipettes since 2010. A brief history of nanopipettes is introduced, and the details of fabrication, modification, and characterization of nanopipettes are provided. Applications of nanopipettes in chemical analysis are the focus in several cases, including recent progress in imaging; in the study of single molecules, single nanoparticles, and single cells; in fundamental investigations of charge transfer (ion and electron) reactions at liquid/liquid interfaces; and as hyphenated techniques combined with other methods to study the mechanisms of complicated electrochemical reactions and to conduct bioanalysis. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125840DOI Listing
June 2018
3 Reads

Relative and Absolute Quantitation in Mass Spectrometry-Based Proteomics.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):49-77

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA; email:

Mass spectrometry-based quantitative proteomics is a powerful tool for gaining insights into function and dynamics of biological systems. However, peptides with different sequences have different ionization efficiencies, and their intensities in a mass spectrum are not correlated with their abundances. Therefore, various label-free or stable isotope label-based quantitation methods have emerged to assist mass spectrometry to perform comparative proteomic experiments, thus enabling nonbiased identification of thousands of proteins differentially expressed in healthy versus diseased cells. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061516-045357DOI Listing

Single-Molecule Force Spectroscopy of Transmembrane β-Barrel Proteins.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06;11(1):375-395

Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland; email:

Single-molecule force spectroscopy (SMFS) has been widely applied to study the mechanical unfolding and folding of transmembrane proteins. Here, we review the recent progress in characterizing bacterial and human transmembrane β-barrel proteins by SMFS. First, we describe the mechanical unfolding of transmembrane β-barrels, which follows a general mechanism dictated by the sequential unfolding and extraction of individual β-strands and β-hairpins from membranes. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-anchem-061
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http://dx.doi.org/10.1146/annurev-anchem-061417-010055DOI Listing
June 2018
15 Reads

Improving Lateral Flow Assay Performance Using Computational Modeling.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 29;11(1):219-244. Epub 2018 Mar 29.

Intellectual Ventures Laboratory, Bellevue, Washington 98007, USA.

The performance, field utility, and low cost of lateral flow assays (LFAs) have driven a tremendous shift in global health care practices by enabling diagnostic testing in previously unserved settings. This success has motivated the continued improvement of LFAs through increasingly sophisticated materials and reagents. However, our mechanistic understanding of the underlying processes that drive the informed design of these systems has not received commensurate attention. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125737DOI Listing

3D Printed Organ Models for Surgical Applications.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 28;11(1):287-306. Epub 2018 Mar 28.

Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA; email:

Medical errors are a major concern in clinical practice, suggesting the need for advanced surgical aids for preoperative planning and rehearsal. Conventionally, CT and MRI scans, as well as 3D visualization techniques, have been utilized as the primary tools for surgical planning. While effective, it would be useful if additional aids could be developed and utilized in particularly complex procedures involving unusual anatomical abnormalities that could benefit from tangible objects providing spatial sense, anatomical accuracy, and tactile feedback. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082023PMC
June 2018
7 Reads

Boron Doped Diamond: A Designer Electrode Material for the Twenty-First Century.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 26;11(1):463-484. Epub 2018 Mar 26.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; email: ,

Boron doped diamond (BDD) is continuing to find numerous electrochemical applications across a diverse range of fields due to its unique properties, such as having a wide solvent window, low capacitance, and reduced resistance to fouling and mechanical robustness. In this review, we showcase the latest developments in the BDD electrochemical field. These are driven by a greater understanding of the relationship between material (surface) properties, required electrochemical performance, and improvements in synthetic growth/fabrication procedures, including material postprocessing. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-010107DOI Listing
June 2018
3 Reads

Analytical Chemistry in the Regulatory Science of Medical Devices.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 26;11(1):307-327. Epub 2018 Mar 26.

Division of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Office of Medical Products and Tobacco, US Food and Drug Administration, Silver Spring, Maryland 20993, USA; email:

In the United States, regulatory science is the science of developing new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of all Food and Drug Administration-regulated products. Good regulatory science facilitates consumer access to innovative medical devices that are safe and effective throughout the Total Product Life Cycle (TPLC). Because the need to measure things is fundamental to the regulatory science of medical devices, analytical chemistry plays an important role, contributing to medical device technology in two ways: It can be an integral part of an innovative medical device (e. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125556DOI Listing
June 2018
1 Read

Interfacing Cells with Vertical Nanoscale Devices: Applications and Characterization.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 23;11(1):101-126. Epub 2018 Mar 23.

Department of Chemistry, Stanford University, Stanford, California 94305, USA; email:

Measurements of the intracellular state of mammalian cells often require probes or molecules to breach the tightly regulated cell membrane. Mammalian cells have been shown to grow well on vertical nanoscale structures in vitro, going out of their way to reach and tightly wrap the structures. A great deal of research has taken advantage of this interaction to bring probes close to the interface or deliver molecules with increased efficiency or ease. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125705DOI Listing
June 2018
1 Read

Voltammetric Perspectives on the Acidity Scale and H/H Process in Ionic Liquid Media.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 19;11(1):397-419. Epub 2018 Mar 19.

School of Chemistry and Australian Research Council Centre of Excellence for Electromaterials Science, Monash University, Clayton, Victoria 3800, Australia; email: ,

Nonhaloaluminate ionic liquids (ILs) have received considerable attention as alternatives to molecular solvents in diverse applications spanning the fields of physical, chemical, and biological science. One important and often overlooked aspect of the implementation of these designer solvents is how the properties of the IL formulation affect (electro)chemical reactivity. This aspect is emphasized herein, where recent (voltammetric) studies on the energetics of proton (H) transfer and electrode reaction mechanisms of the H/H process in IL media are highlighted and discussed. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-010022DOI Listing

SERS Sensors: Recent Developments and a Generalized Classification Scheme Based on the Signal Origin.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 16;11(1):147-169. Epub 2018 Mar 16.

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA; email:

Owing to its extreme sensitivity and easy execution, surface-enhanced Raman spectroscopy (SERS) now finds application for a wide variety of problems requiring sensitive and targeted analyte detection. This widespread application has prompted a proliferation of different SERS-based sensors, suggesting the need for a framework to classify existing methods and guide the development of new techniques. After a brief discussion of the general SERS modalities, we classify SERS-based sensors according the origin of the signal. Read More

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https://www.annualreviews.org/doi/10.1146/annurev-anchem-061
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http://dx.doi.org/10.1146/annurev-anchem-061417-125724DOI Listing
June 2018
5 Reads

Nanoscale Electrochemical Sensing and Processing in Microreactors.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 8;11(1):421-440. Epub 2018 Mar 8.

MESA+ Institute for Nanotechnology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede 7500 AE, The Netherlands; email:

In this review, we summarize recent advances in nanoscale electrochemistry, including the use of nanoparticles, carbon nanomaterials, and nanowires. Exciting developments are reported for nanoscale redox cycling devices, which can chemically amplify signal readout. We also discuss promising high-frequency techniques such as nanocapacitive CMOS sensor arrays or heterodyning. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125642DOI Listing
June 2018
1 Read

Methods of Measuring Enzyme Activity Ex Vivo and In Vivo.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 5;11(1):509-533. Epub 2018 Mar 5.

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA; email:

Enzymes catalyze a variety of biochemical reactions in the body and, in conjunction with transporters and receptors, control virtually all physiological processes. There is great value in measuring enzyme activity ex vivo and in vivo. Spatial and temporal differences or changes in enzyme activity can be related to a variety of natural and pathological processes. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147230PMC
June 2018
3 Reads

(Multi)functional Atomic Force Microscopy Imaging.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 28;11(1):329-350. Epub 2018 Feb 28.

Institute of Analytical and Bioanalytical Chemistry, Ulm University, Ulm 89081, Germany; email:

Incorporating functionality to atomic force microscopy (AFM) to obtain physical and chemical information has always been a strong focus in AFM research. Modifying AFM probes with specific molecules permits accessibility of chemical information via specific reactions and interactions. Fundamental understanding of molecular processes at the solid/liquid interface with high spatial resolution is essential to many emerging research areas. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125716DOI Listing

Electrochemical Probes of Microbial Community Behavior.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 28;11(1):441-461. Epub 2018 Feb 28.

Department of Chemical Engineering, Northeastern University, Boston, Massachusetts 02115, USA; email:

Advances in next-generation sequencing technology along with decreasing costs now allow the microbial population, or microbiome, of a location to be determined relatively quickly. This research reveals that microbial communities are more diverse and complex than ever imagined. New and specialized instrumentation is required to investigate, with high spatial and temporal resolution, the dynamic biochemical environment that is created by microbes, which allows them to exist in every corner of the Earth. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125627DOI Listing

Gas Cluster Ion Beams for Secondary Ion Mass Spectrometry.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 28;11(1):29-48. Epub 2018 Feb 28.

Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, USA; email:

Gas cluster ion beams (GCIBs) provide new opportunities for bioimaging and molecular depth profiling with secondary ion mass spectrometry (SIMS). These beams, consisting of clusters containing thousands of particles, initiate desorption of target molecules with high yield and minimal fragmentation. This review emphasizes the unique opportunities for implementing these sources, especially for bioimaging applications. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061516-045249DOI Listing

Wearable and Implantable Sensors for Biomedical Applications.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 28;11(1):127-146. Epub 2018 Feb 28.

Electrical and Computer Engineering Department, University of California, Los Angeles, California 90095, USA; email:

Mobile health technologies offer great promise for reducing healthcare costs and improving patient care. Wearable and implantable technologies are contributing to a transformation in the mobile health era in terms of improving healthcare and health outcomes and providing real-time guidance on improved health management and tracking. In this article, we review the biomedical applications of wearable and implantable medical devices and sensors, ranging from monitoring to prevention of diseases, as well as the materials used in the fabrication of these devices and the standards for wireless medical devices and mobile applications. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125956DOI Listing
June 2018
2 Reads

Nano-Enabled Approaches to Chemical Imaging in Biosystems.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 28;11(1):351-373. Epub 2018 Feb 28.

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA; email:

Understanding and predicting how biosystems function require knowledge about the dynamic physicochemical environments with which they interact and alter by their presence. Yet, identifying specific components, tracking the dynamics of the system, and monitoring local environmental conditions without disrupting biosystem function present significant challenges for analytical measurements. Nanomaterials, by their very size and nature, can act as probes and interfaces to biosystems and offer solutions to some of these challenges. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125635DOI Listing
June 2018
1 Read

DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 28;11(1):171-195. Epub 2018 Feb 28.

Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility (SSRF), Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; email:

Biosensors represent biomimetic analytical tools for addressing increasing needs in medical diagnosis, environmental monitoring, security, and biodefense. Nevertheless, widespread real-world applications of biosensors remain challenging due to limitations of performance, including sensitivity, specificity, speed, and reproducibility. In this review, we present a DNA nanotechnology-enabled interfacial engineering approach for improving the performance of biosensors. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-010007DOI Listing
June 2018
6 Reads

Technologies for Measuring Pharmacokinetic Profiles.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 11;11(1):79-100. Epub 2018 Jan 11.

Department of Biomedical Engineering, Michigan State University, East Lansing, Michigan 48824, USA.

The creation of a pharmacokinetic (PK) curve, which follows the plasma concentration of an administered drug as a function of time, is a critical aspect of the drug development process and includes such information as the drug's bioavailability, clearance, and elimination half-life. Prior to a drug of interest gaining clearance for use in human clinical trials, research is performed during the preclinical stages to establish drug safety and dosing metrics from data obtained from the PK studies. Both in vivo animal models and in vitro platforms have limitations in predicting human reaction to a drug due to differences in species and associated simplifications, respectively. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125611DOI Listing
June 2018
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Recent Advances in Solid-State Nuclear Magnetic Resonance Spectroscopy.

Annu Rev Anal Chem (Palo Alto Calif) 2018 06 11;11(1):485-508. Epub 2018 Jan 11.

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom.

The sensitivity of nuclear magnetic resonance (NMR) spectroscopy to the local atomic-scale environment offers great potential for the characterization of a diverse range of solid materials. Despite offering more information than its solution-state counterpart, solid-state NMR has not yet achieved a similar level of recognition, owing to the anisotropic interactions that broaden the spectral lines and hinder the extraction of structural information. Here, we describe the methods available to improve the resolution of solid-state NMR spectra and the continuing research in this area. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061417-125852DOI Listing
June 2018
2 Reads

Analyzing the Heterogeneous Hierarchy of Cultural Heritage Materials: Analytical Imaging.

Authors:
Karen Trentelman

Annu Rev Anal Chem (Palo Alto Calif) 2017 Jun;10(1):247-270

Getty Conservation Institute, Los Angeles, California 90049; email:

Objects of cultural heritage significance are created using a wide variety of materials, or mixtures of materials, and often exhibit heterogeneity on multiple length scales. The effective study of these complex constructions thus requires the use of a suite of complementary analytical technologies. Moreover, because of the importance and irreplaceability of most cultural heritage objects, researchers favor analytical techniques that can be employed noninvasively, i. Read More

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http://dx.doi.org/10.1146/annurev-anchem-071015-041500DOI Listing
June 2017
3 Reads

Multianalyte Physiological Microanalytical Devices.

Annu Rev Anal Chem (Palo Alto Calif) 2017 06;10(1):93-111

Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235; email:

Advances in scientific instrumentation have allowed experimentalists to evaluate well-known systems in new ways and to gain insight into previously unexplored or poorly understood phenomena. Within the growing field of multianalyte physiometry (MAP), microphysiometers are being developed that are capable of electrochemically measuring changes in the concentration of various metabolites in real time. By simultaneously quantifying multiple analytes, these devices have begun to unravel the complex pathways that govern biological responses to ischemia and oxidative stress while contributing to basic scientific discoveries in bioenergetics and neurology. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061516-045334DOI Listing
June 2017
1 Read

Nanosensor Technology Applied to Living Plant Systems.

Annu Rev Anal Chem (Palo Alto Calif) 2017 06;10(1):113-140

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachussetts 02139; email:

An understanding of plant biology is essential to solving many long-standing global challenges, including sustainable and secure food production and the generation of renewable fuel sources. Nanosensor platforms, sensors with a characteristic dimension that is nanometer in scale, have emerged as important tools for monitoring plant signaling pathways and metabolism that are nondestructive, minimally invasive, and capable of real-time analysis. This review outlines the recent advances in nanotechnology that enable these platforms, including the measurement of chemical fluxes even at the single-molecule level. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061516-045310DOI Listing
June 2017
21 Reads

The Solution Assembly of Biological Molecules Using Ion Mobility Methods: From Amino Acids to Amyloid β-Protein.

Annu Rev Anal Chem (Palo Alto Calif) 2017 06 24;10(1):365-386. Epub 2017 Mar 24.

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106.

Ion mobility spectrometry-mass spectrometry (IMS-MS) methods are increasingly used to study noncovalent assemblies of peptides and proteins. This review focuses on the noncovalent self-assembly of amino acids and peptides, systems at the heart of the amyloid process that play a central role in a number of devastating diseases. Three different systems are discussed in detail: the 42-residue peptide amyloid-β42 implicated in the etiology of Alzheimer's disease, several amyloid-forming peptides with 6-11 residues, and the assembly of individual amino acids. Read More

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http://dx.doi.org/10.1146/annurev-anchem-071114-040304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287953PMC
June 2017
9 Reads

Tailored Surfaces/Assemblies for Molecular Plasmonics and Plasmonic Molecular Electronics.

Annu Rev Anal Chem (Palo Alto Calif) 2017 Jun 24;10(1):201-224. Epub 2017 Mar 24.

Department of Chemistry, University of Paris Diderot, ITODYS, Paris 75205, France; email:

Molecular plasmonics uses and explores molecule-plasmon interactions on metal nanostructures for spectroscopic, nanophotonic, and nanoelectronic devices. This review focuses on tailored surfaces/assemblies for molecular plasmonics and describes active molecular plasmonic devices in which functional molecules and polymers change their structural, electrical, and/or optical properties in response to external stimuli and that can dynamically tune the plasmonic properties. We also explore an emerging research field combining molecular plasmonics and molecular electronics. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061516-045325DOI Listing
June 2017
8 Reads