1,535 results match your criteria Annals of transplantation[Journal]


Postoperative Serum Lactate Levels for In-Hospital Mortality Prediction Among Heart Transplant Recipients.

Ann Transplant 2020 May 26;25:e920288. Epub 2020 May 26.

Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Cracow, Poland.

BACKGROUND Hyperlactatemia is a common phenomenon following cardiac surgeries and is associated with prolonged ICU stay and higher morbidity and mortality rates, but such analyses have never focused on patients undergoing heart transplantation (HTX), in whom hyperlactatemia defined with the traditional threshold is observed in nearly every individual. The present study aimed to assess the prognostic value and clinical usefulness of postoperative serum lactate level measurements for in-hospital mortality prediction following HTX. MATERIAL AND METHODS Forty-six consecutive patients who underwent HTX in the Department of Cardiovascular Surgery and Transplantology between 2010 and 2015 were enrolled into a retrospective analysis. Read More

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http://dx.doi.org/10.12659/AOT.920288DOI Listing

Bacterial and Fungal Infections After Liver Transplantation: Microbial Epidemiology, Risk Factors for Infection and Death with Infection.

Ann Transplant 2020 May 19;25:e921591. Epub 2020 May 19.

Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND Infections, especially bacterial and fungal infections, are the leading cause of high mortality after liver transplantation (LT). This research investigated the pathogenic spectrum, antimicrobial susceptibility results, and risk factors of infection and death with infection to better control such infections. MATERIAL AND METHODS A retrospective cohort study was performed, and 433 liver transplant recipients between January 2010 and December 2016 were analyzed. Read More

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http://dx.doi.org/10.12659/AOT.921591DOI Listing

Developing an Organ Donation Curriculum for Medical Undergraduates in China Based on Theory of Planned Behavior: A Delphi Method Study.

Ann Transplant 2020 May 15;25:e922809. Epub 2020 May 15.

School of Nursing, Third Military Medical University, Chongqing, China (mainland).

BACKGROUND Organ donation education as an important approach to improve support for donating, but it is inconsistent and unstructured. Therefore, the development of donation-related curriculum is essential, especially for medical undergraduates. This study aimed to define the fundamental contents for organ donation curriculum that could be useful for international organ donor agencies and educational institutions. Read More

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http://dx.doi.org/10.12659/AOT.922809DOI Listing

Comparison of Cardioprotective Effects of Propofol versus Sevoflurane in Pediatric Living Donor Liver Transplantation.

Ann Transplant 2020 May 12;25:e923398. Epub 2020 May 12.

Department of Anesthesiology, Tianjin First Center Hospital, Tianjin, China (mainland).

BACKGROUND Our study compared the myocardiac protective effect of propofol vs. sevoflurane in pediatric patients receiving living donor liver transplantation (LDLT) surgery. MATERIAL AND METHODS We randomly and equally divided 120 children who underwent LDLT into a sevoflurane group and a propofol group. Read More

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http://dx.doi.org/10.12659/AOT.923398DOI Listing

Toll-Like Receptor 3 Activator Preconditioning Enhances Modulatory Function of Adipose‑Derived Mesenchymal Stem Cells in a Fully MHC-Mismatched Murine Model of Heterotopic Heart Transplantation.

Ann Transplant 2020 May 5;25:e921287. Epub 2020 May 5.

The Key Laboratory of Organ Transplantation in Liaoning Province, Shenyang, Liaoning, China (mainland).

BACKGROUND Donor-specific tolerance is the ultimate goal in organ transplantation. Diverse approaches, including the use of mesenchymal stem cells (MSCs), have been investigated to induce graft tolerance. Non-stimulated MSCs showed limited regulatory functions through interaction with multiple immune-regulatory cells, such as regulatory T cells (Tregs). Read More

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http://dx.doi.org/10.12659/AOT.921287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219555PMC

Serial Peripheral Blood Gene Expression Profiling to Assess Immune Quiescence in Kidney Transplant Recipients with Stable Renal Function.

Ann Transplant 2020 Apr 28;25:e920839. Epub 2020 Apr 28.

Transplant Genomics Inc., Mansfield, MA, USA.

BACKGROUND TruGraf is a blood-based biomarker test that measures differential expression of a collection of genes that have been shown to correlate with surveillance biopsy results. However, in the majority of U.S. Read More

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http://dx.doi.org/10.12659/AOT.920839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204430PMC

First Preliminary Experience with Preservation of Liver Grafts from Extended-Criteria Donors by Normothermic Machine Perfusion in Asia.

Ann Transplant 2020 Apr 21;25:e921529. Epub 2020 Apr 21.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. CASE REPORT From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. Read More

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http://dx.doi.org/10.12659/AOT.921529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193227PMC
April 2020
1.430 Impact Factor

A Retrospective Cohort Study of the Effect of Gout on Mortality Among Patients with a History of Kidney Transplantation.

Ann Transplant 2020 Apr 14;25:e920553. Epub 2020 Apr 14.

Trinity Partners, LLC, Waltham, MA, USA.

BACKGROUND Kidney transplantation is associated with increased prevalence of gout. However, evidence of the effect of gout on long-term kidney transplantation outcomes is mixed. This study examined mortality risk among patients with a history of kidney transplantation with vs. Read More

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http://dx.doi.org/10.12659/AOT.920553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177036PMC

Everolimus-Eluting Second-Generation Stents for Treatment of De Novo Lesions in Patients with Cardiac Allograft Vasculopathy.

Ann Transplant 2020 Apr 7;25:e921266. Epub 2020 Apr 7.

Silesian Center for Heart Diseases, Zabrze, Poland.

BACKGROUND Cardiac allograft vasculopathy is a major cause of cardiac allograft rejection. Percutaneous coronary intervention has become the main form of treatment of significant focal lesions. Despite the significance of the problem, data remain scarce. Read More

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http://dx.doi.org/10.12659/AOT.921266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163333PMC

Prophylaxis of Hepatitis B Virus (HBV) Re-Infection in Liver Transplantation: Is the Reappearance of Hepatitis B Surface Antigen (HBsAg) Significant?

Ann Transplant 2020 Mar 31;25:e920969. Epub 2020 Mar 31.

Department of Mental and Physical Health and Preventive Medicine, Infectious Disease Unit, University of Campania Luigi Vanvitelli, Naples, Italy.

The recurrence of hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) was in the past a primary cause of organ loss or mortality. Currently, post-OLT prophylaxis with anti-HBs immunoglobulins plus a nucleos(t)ide analogue has virtually abolished the risk of re-infection. Some studies have proposed to simplify prophylaxis by discontinuing immunoglobulins while continuing the analogue alone. Read More

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http://dx.doi.org/10.12659/AOT.920969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146063PMC

Optimizing Organ Donation: Expert Opinion from Austria, Germany, Spain and the U.K.

Ann Transplant 2020 Mar 17;25:e921727. Epub 2020 Mar 17.

Department of General, Visceral and Transplant Surgery, Medical University Graz, Graz, Austria.

BACKGROUND Organ donation-rates using deceased donors and organizational approaches to organ donation differ drastically between countries at a similar level of health care as measured by the Euro Health Consumer Index (EHCI). MATERIAL AND METHODS Expert opinions from intensive care nurses, physicians, transplant coordinators and transplant surgeons from Austria, Germany, Spain, and the U.K. Read More

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http://dx.doi.org/10.12659/AOT.921727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101202PMC
March 2020
1.430 Impact Factor

Recipient Hepatic Tumor-Associated Immunologic Infiltrates Predict Outcomes After Liver Transplantation for Hepatocellular Carcinoma.

Ann Transplant 2020 Mar 13;25:e919414. Epub 2020 Mar 13.

Department of Visceral-, Transplantation-, Thoracic- and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.

BACKGROUND Transplantation of the liver entails a state of altered recipient immunologic competence. There are only scarce data concerning the impact of host immunologic factors on the outcome of liver transplant recipients in the context of hepatocellular carcinoma (HCC). MATERIAL AND METHODS Our study focused on evaluating the presence of tumor necrosis and frequency levels of angiopoietins and monocytes/macrophages subtypes in the host liver prior to liver transplantation (LTX) and their association with recurrence, graft rejection, survival, and clinical prognosis after LTX. Read More

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http://dx.doi.org/10.12659/AOT.919414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092657PMC

Clinical Outcome of Residual Liver Volume and Hepatic Steatosis After Right-Lobe Living-Donor Hepatectomy.

Ann Transplant 2020 Mar 10;25:e919502. Epub 2020 Mar 10.

Department of General Surgery, Changhua Christian Hospital, Changhua, Taiwan.

BACKGROUND We examine how residual liver volume (RLV) and hepatic steatosis (HS) of living liver donors affect the regeneration process and clinical outcomes. MATERIAL AND METHODS We longitudinally studied 58 donors who underwent right-lobe hepatectomy during the period February 2014 to February 2015 at a single medical institution. The patients were classified based on RLV (30-35%, 35-40%, 40-50%) subgroups and HS (<10%, 10-30%, 30-50%) subgroups. Read More

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http://dx.doi.org/10.12659/AOT.919502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083085PMC

Diffusion Weighted Magnetic Resonance Imaging in the Assessment of Renal Function and Parenchymal Changes in Chronic Kidney Disease: A Preliminary Study.

Ann Transplant 2020 Mar 3;25:e920232. Epub 2020 Mar 3.

Department of Surgical and Transplantation Nursing and Extracorporeal Therapies, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND The aim of this study was to evaluate the feasibility of using intravoxel incoherent motion (IVIM) imaging for noninvasive assessment of pathologic changes in chronic kidney disease (CKD). MATERIAL AND METHODS Thirty-four patients with CKD and 20 healthy volunteers were examined on a 1.5 T magnetic resonance imaging (MRI) unit. Read More

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http://dx.doi.org/10.12659/AOT.920232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069451PMC

Efficacy and Safety of a Quadruple Regimen Compared with Triple Regimens in Patients with Mycophenolic Acid-Related Gastrointestinal Complications After Renal Transplantation: A Short-Term Single-Center Study.

Ann Transplant 2020 Feb 28;25:e919875. Epub 2020 Feb 28.

Department of Organ Transplantation, Qilu Hospital of Shan Dong University, Jinan, Shandong, China (mainland).

BACKGROUND At present, there is no ideal conventional triple regimen that can effectively treat gastrointestinal (GI) complications in patients after kidney transplantation. We aimed to investigate the efficacy and safety of a quadruple regimen including standard-dose tacrolimus, low-dose enteric-coated mycophenolate sodium (EC-MPS), low-dose mizoribine (MZR), and corticosteroids, compared with regimens containing standard-dose tacrolimus, corticosteroids, plus either low-dose EC-MPS or standard-dose MZR in patients with mycophenolic acid (MPA)-related GI complications after renal transplantation. MATERIAL AND METHODS Between August 2016 and October 2018 in Qilu Hospital of Shandong University, 115 living donor kidney transplant recipients with MPA-related GI complications were enlisted in a single-center, prospective, randomized, control study. Read More

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http://dx.doi.org/10.12659/AOT.919875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065508PMC
February 2020

Effects of Delayed Hypothermic Machine Perfusion on Kidney Grafts with a Preliminary Period of Static Cold Storage and a Total Cold Ischemia Time of Over 24 Hours.

Ann Transplant 2020 Feb 25;25:e918997. Epub 2020 Feb 25.

Department of Medicine, General Surgery and Transplantation, Academic Hospital (ASUIUD), University of Udine, Udine, Italy.

BACKGROUND Hypothermic machine perfusion (HMP) appears to exert a reconditioning effect on the ischemic damage of kidney grafts. However, some concerns still remain about its real effectiveness when it is delayed after a preliminary period of static cold storage (SCS) or with prolonged overall cold ischemia time (CIT). MATERIAL AND METHODS The effect of HMP on hemodynamic, metabolic, histological and ultrastructural features of grafts was investigated in 21 single-kidney grafts treated with a delayed HMP after SCS and with a total CIT of over 24 h. Read More

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http://dx.doi.org/10.12659/AOT.918997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059438PMC
February 2020

Effect of Rewarming on Leukocyte-Endothelial Interaction After Deep Hypothermic Preservation.

Ann Transplant 2020 Feb 21;25:e919540. Epub 2020 Feb 21.

Department of Cardiothoracic and Vascular Surgery, University Hospital Mainz, Johannes-Gutenberg University, Mainz, Germany.

BACKGROUND The preservation of harvested organs plays an essential role in transplantation. Cold hypothermia is frequently applied but may lead to graft compromise resulting from reperfusion and rewarming injury. This study investigates the effect of deep hypothermia and posterior rewarming on leukocyte-endothelial interactions and junctional adhesion molecules. Read More

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http://dx.doi.org/10.12659/AOT.919540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057734PMC
February 2020

Sleep Quality and Psychosocial Factors in Liver Transplant Recipients at an Outpatient Follow-Up Clinic in China.

Ann Transplant 2020 Feb 18;25:e920984. Epub 2020 Feb 18.

Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, The Third Affiliated Hospital, Central South University, Changsha, Hunan, China (mainland).

BACKGROUND Sleep disturbance is a common problem in liver transplant recipients, but few studies have confirmed the psychosocial factors associated with sleep quality in patients after liver transplantation. This study aimed to identify the psychosocial factors related to sleep quality among liver transplant patients during outpatient follow-up. MATERIAL AND METHODS A retrospective cross-sectional study was performed in 124 liver transplant patients during outpatient follow-up. Read More

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http://dx.doi.org/10.12659/AOT.920984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047916PMC
February 2020

Attitudes and Awareness Towards Organ Donation Among Parents of Pediatric Brain Death Patients in a Pediatric Intensive Care Unit in Eastern Turkey.

Authors:
Osman Yeşilbaş

Ann Transplant 2020 Feb 14;25:e920527. Epub 2020 Feb 14.

Specialist Pediatric Critical Care, Pediatric Intensive Care Unit, Van Research and Training Hospital, University of Health Sciences, Van, Turkey.

BACKGROUND The real causes of organ donation refusal decisions of parents after pediatric brain death and the factors that most influence their decisions are not known sufficiently in Turkey. This study aimed to investigate the detailed factors that may be relevant to parents' refusal, including their education level and knowledge about organ donation. MATERIAL AND METHODS Between August 2017 and September 2018, parents who had been asked to allow organ donation from their deceased child were included in this study. Read More

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http://dx.doi.org/10.12659/AOT.920527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034400PMC
February 2020

Evolution of Laparoscopic Donor Nephrectomy Techniques and Outcomes: A Single-Center Experience with More than 1000 Cases.

Ann Transplant 2020 Feb 11;25:e918189. Epub 2020 Feb 11.

Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

BACKGROUND Laparoscopic donor nephrectomy (LDN) has evolved and has been established as a surgical standard of care for kidney transplantation. MATERIAL AND METHODS This study retrospectively reviews 1132 patients who underwent 4 different laparoscopic living-donor nephrectomies: hand-assisted laparoscopic nephrectomy (HALDN), pure laparoscopic donor nephrectomy (PLDN), laparoendoscopic single-site plus 1-port donor nephrectomy (LESSOP-DN), and mini laparoscopic donor nephrectomy (MLDN). RESULTS The mean estimated blood loss (EBL) for the HALDN group was meaningfully higher than those of LESSOP-DN and MLDN (57. Read More

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http://dx.doi.org/10.12659/AOT.918189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034519PMC
February 2020

Individualized Preconditioning for ABO-Incompatible Living-Donor Kidney Transplantation: An Initial Report of 48 Cases from China.

Ann Transplant 2020 Feb 7;25:e920224. Epub 2020 Feb 7.

Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND ABO-incompatible (ABOi) living-donor kidney transplantation (KTx) is well established in developed countries, but not yet in China. MATERIAL AND METHODS We developed individualized preconditioning protocols for ABOi KTx based on initial ABO antibody titers. After propensity score matching of ABOi with ABO-compatible (ABOc) KTx, post-transplant outcomes were compared. Read More

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http://dx.doi.org/10.12659/AOT.920224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029655PMC
February 2020
1.430 Impact Factor

Diagnosis and Treatment of Renal Artery Stenosis in China in the Era of Donation After Cardiac Death.

Ann Transplant 2020 Feb 4;25:e918076. Epub 2020 Feb 4.

Organ Transplant Institute, The 8TH Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China (mainland).

BACKGROUND The aim of this study was to investigate the clinical features and treatment strategies of transplant renal artery stenosis (TRAS) with kidneys from donation after cardiac death (DCD). MATERIAL AND METHODS We collected the clinical data of donors and recipients of single-center DCD-induced TRAS from January 2015 to June 2017. RESULTS All the 8 cases of TRAS were from hypertensive cerebrovascular accident DCD-originated kidneys. Read More

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http://dx.doi.org/10.12659/AOT.918076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023544PMC
February 2020

Clinical Features and Long-Term Outcomes of Living Donors of Liver Transplantation Who Developed Psychiatric Disorders.

Ann Transplant 2020 Jan 31;25:e918500. Epub 2020 Jan 31.

Department of Transplantation Surgery, Nagoya University Hospital, Nagoya, Aichi, Japan.

BACKGROUND In the field of living donor liver transplantation (LDLT), it is important to ensure donor's psychological well-being. We report on clinical features and long-term outcomes of LDLT donors who developed psychiatric disorders after their donor operations. Additionally, we compare patient backgrounds, as well as surgical and perioperative aspects between LDLT donors with and without postoperative psychiatric complications. Read More

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http://dx.doi.org/10.12659/AOT.918500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011571PMC
January 2020

Acute Kidney Injury and Renal Regional Oxygen Saturation During Pediatric Liver Transplantation.

Ann Transplant 2020 Jan 28;25:e919717. Epub 2020 Jan 28.

Department of Anesthesiology, University Hospital Regensburg, Regensburg, Germany.

BACKGROUND Kidney injury is a complication among children undergoing liver transplantation (pLTx). Cystatin C serum concentration seems to be superior to creatinine-based determination of kidney injury in adults and children. Near-infrared spectroscopy (NIRS) technology provides non-invasive and real-time measurement of renal tissue oxygenation. Read More

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http://dx.doi.org/10.12659/AOT.919717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006365PMC
January 2020

Different Routes of Proton Pumps Inhibitors Co-Administration have Significant Impact on Mycophenolate Acid (MPA) Serum Levels in Heart Transplant Recipients.

Ann Transplant 2020 Jan 24;25:e920225. Epub 2020 Jan 24.

Department of Cardiac Surgery and Transplantology, Holy Saint Configuration Hospital University of Medical Sciences, Poznań, Poland.

BACKGROUND Antiproliferative drugs including mycophenolate mofetil (MMF) are widely accepted part of an immunosuppressive therapy following heart transplantation. Proton pump inhibitors (PPIs) are routinely administered after cardiac surgery procedures including transplantation. They may also have impact on mycophenolate acid (MPA) serum levels. Read More

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http://dx.doi.org/10.12659/AOT.920225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003660PMC
January 2020

Perioperative Pleural Drainage in Liver Transplantation: A Retrospective Analysis from a High-Volume Liver Transplant Center.

Ann Transplant 2020 Jan 17;25:e918456. Epub 2020 Jan 17.

Department of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

BACKGROUND Pleural effusions represent a common complication after liver transplantation (LT) and chest drain (CD) placement is frequently necessary. MATERIAL AND METHODS In this retrospective cohort study, adult LT recipients between 2009 and 2016 were analyzed for pleural effusion formation and its treatment within the first 10 postoperative days. The aim of the study was to compare different settings of CD placement with regard to intervention-related complications. Read More

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http://dx.doi.org/10.12659/AOT.918456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988474PMC
January 2020

Applicability of Hypothermic Oxygenate Machine Perfusion Preservation for Split-Liver Transplantation in a Porcine Model: An Experimental Study.

Ann Transplant 2020 Jan 14;25:e919920. Epub 2020 Jan 14.

Department of Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

BACKGROUND Split-liver transplantation can be useful in situations of limited donor resources. However, novel preservation methods are required to help the recipient recover from severe ischemic reperfusion injury incurred due to receiving a relatively small liver graft. MATERIAL AND METHODS Our experiment was performed using porcine livers without warm ischemia time, assuming a brain-dead organ. Read More

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http://dx.doi.org/10.12659/AOT.919920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978992PMC
January 2020

Outcome of Living-Donor Liver Transplantation Using Grafts from Donors Treated for Fatty Liver.

Ann Transplant 2020 Jan 10;25:e920677. Epub 2020 Jan 10.

Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.

BACKGROUND The aim of this study was to determine the efficacy of treating donors' fatty liver (FL) and to assess early graft function in recipients who received treated FL grafts in living-donor liver transplantation (LDLT). MATERIAL AND METHODS Data were collected for adult-to-adult LDLTs. Donors diagnosed with FL (FL group) received diet-exercise and pharmacological treatment. Read More

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http://dx.doi.org/10.12659/AOT.920677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977639PMC
January 2020
1.430 Impact Factor

Knowledge Does Not Correlate with Behavior toward Deceased Organ Donation: A Cross-Sectional Study in Japan.

Ann Transplant 2020 Jan 3;25:e918936. Epub 2020 Jan 3.

Department of Healthcare Epidemiology, School of Public Health in The Graduate School of Medicine, Kyoto University, Kyoto, Japan.

BACKGROUND Although knowledge is an important factor that influences decisions regarding deceased organ donation, the associations of knowledge with attitude and behavior regarding organ donation remain uncertain in countries with low organ donation rates like Japan. MATERIAL AND METHODS We conducted a cross-sectional survey of hospital medical and non-medical staff in 15 Japanese medical facilities. The questionnaire included items on knowledge, attitude, and behavior toward deceased organ donation and transplantation. Read More

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http://dx.doi.org/10.12659/AOT.918936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977621PMC
January 2020

The Conversional Efficacy of Ex Vivo Lung Perfusion and Clinical Outcomes in Patients Undergoing Transplantation of Donor Lungs by Ex Vivo Lung Perfusion: A Meta-Analysis.

Ann Transplant 2019 Dec 27;24:647-660. Epub 2019 Dec 27.

Department of Thoracic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).

Background: Ex vivo lung perfusion (EVLP) is a relatively new technique that can be used to assess and repair the donor lungs, increasing the utilization of high-risk lungs. However, its effect on outcomes of lung transplantation patients is uncertainty. This meta-analysis is conducted to assess the impact of EVLP on donor lungs and outcomes of recipients compared with the standard lung transplantation. Read More

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http://dx.doi.org/10.12659/AOT.919242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951108PMC
December 2019

Hemashield Vascular Graft Is a Preferable Prosthetic Graft for Middle Hepatic Vein Reconstruction in Living Donor Liver Transplantation.

Ann Transplant 2019 Dec 17;24:639-646. Epub 2019 Dec 17.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

BACKGROUND Because of the supply shortage for homologous vein allografts, we previously used ringed Gore-Tex vascular grafts for middle hepatic vein (MHV) reconstruction in living donor liver transplantation. However, owing to the subsequent unavailability of ringed Gore-Tex grafts, we replaced them with Hemashield vascular grafts. This study aimed to compare the patency of Hemashield grafts with that of ringed Gore-Tex grafts. Read More

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http://dx.doi.org/10.12659/AOT.919780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936210PMC
December 2019

Post-Reperfusion Syndrome in Liver Transplantation: Does a Caval Blood Flush Vent Help?

Ann Transplant 2019 Dec 13;24:631-638. Epub 2019 Dec 13.

Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston, SC, USA.

BACKGROUND Post-reperfusion syndrome (PRS) during liver transplantation can range from a benign event to a profound hemodynamic excursion from baseline with significant morbidity. Multiple variables can be responsible for the diverse presentations. Over time, our group noticed that a blood flush of the liver graft via a caval vent (in addition to a standard chilled flush via the portal vein) appeared to result in a milder reperfusion effect. Read More

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http://dx.doi.org/10.12659/AOT.920193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930699PMC
December 2019

Impact of Increased Duration of Trimethoprim-Sulfamethoxazole Prophylaxis for Pneumocystis Pneumonia After Renal Transplant.

Ann Transplant 2019 Dec 6;24:625-630. Epub 2019 Dec 6.

Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom.

BACKGROUND Trimethoprim-sulfamethoxazole (TMP-SMX) is recommended as prophylaxis against Pneumocystis pneumonia (PCP) in renal transplant recipients. The optimal duration of prophylaxis is unknown. Longer duration of prophylaxis may increase the risk of adverse effects. Read More

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http://dx.doi.org/10.12659/AOT.918195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918803PMC
December 2019

An Update on Early Urological Complications in Kidney Transplantation: A National Cohort Study.

Ann Transplant 2019 Dec 3;24:617-624. Epub 2019 Dec 3.

Department of Surgery, Radboud University Medical Center Nijmegen, Nijmegen, Netherlands.

BACKGROUND This study aimed to provide an update on the occurrence of early urological complications in living-donor and deceased-donor kidney transplantation (KTX). MATERIAL AND METHODS Data on all kidney transplant recipients in the Netherlands between January 2005 and December 2015 were retrieved from the prospectively collected Dutch National Organ Transplant Registry Database (NOTR). We assessed the incidence of major urological complications (MUCs) within 3 months after KTX, defined as urinary leakage and ureteral obstruction. Read More

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http://dx.doi.org/10.12659/AOT.920086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909919PMC
December 2019

Autoimmune Diabetes Recurrence After Pancreas Transplantation: Diagnosis, Management, and Literature Review.

Ann Transplant 2019 Nov 26;24:608-616. Epub 2019 Nov 26.

Department of Endocrinology and Nutrition, La Fe University and Polytechnic Hospital, Valencia, Spain.

BACKGROUND Pancreas transplantation can be a viable treatment option for patients with type 1 diabetes mellitus (T1DM), especially for those who are candidates for kidney transplantation. T1DM may rarely recur after pancreas transplantation, causing the loss of pancreatic graft. The aim of this study was to describe the prevalence of T1DM recurrence after pancreas transplantation in our series. Read More

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http://dx.doi.org/10.12659/AOT.920106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896746PMC
November 2019

Antithymocyte Globulin: Indiscriminate Use and Complications.

Ann Transplant 2019 11 22;24:605-607. Epub 2019 Nov 22.

Department of Nephrology and Transplantation, Rehman Medical Institute, Peshawar, Pakistan.

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http://dx.doi.org/10.12659/AOT.919655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886324PMC
November 2019
1.430 Impact Factor

Effects of Wuzhi Capsules on Blood Concentration of Tacrolimus in Renal Transplant Recipients.

Ann Transplant 2019 Nov 12;24:594-604. Epub 2019 Nov 12.

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China (mainland).

BACKGROUND Tacrolimus is a widely used immunosuppressant in renal transplant recipients. It was demonstrated in rats and healthy volunteers that Wuzhi capsules could inhibit metabolism and maintain blood concentration of tacrolimus. However, there are no clinical studies of Wuzhi capsules in renal transplant recipients. Read More

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http://dx.doi.org/10.12659/AOT.918980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873908PMC
November 2019

Overcoming Hepatic Artery Thrombosis After Living Donor Liver Transplantations: An Experience from Asan Medical Center.

Ann Transplant 2019 Nov 1;24:588-593. Epub 2019 Nov 1.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

BACKGROUND Hepatic artery (HA) reconstruction in living donor liver transplantation (LDLT) is more technically demanding than deceased donor LT (DDLT) because of the small diameter and short HA stump of the partial liver graft. Hence, hepatic artery thrombosis (HAT) can occur infrequently even though the HA is reconstructed microscopically. HAT is closely related to graft failure and mortality. Read More

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http://dx.doi.org/10.12659/AOT.919650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857352PMC
November 2019
5 Reads

BEAM-Modified Conditioning Therapy with Cisplatin+Dexamethasone Instead of Carmustine Prior to Autologous Hematopoietic Stem Cell Transplantation (HSCT) in Patients with Hodgkin and Non-Hodgkin Lymphoma.

Ann Transplant 2019 Oct 22;24:584-587. Epub 2019 Oct 22.

Hemapoietic Stem Cell Transplantation Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.

BACKGROUND High-dose chemotherapy followed by autologous hematopoietic stem cell transplant has proven useful in relapsed or refractory cases of Hodgkin and non-Hodgkin lymphoma. BEAM (carmustine, etoposide, cytarabine, melphalan) is frequently used as a conditioning regimen; however, the high cost and limited availability of BCNU hinders its use in Mexico. MATERIAL AND METHODS Between January 2013 and February 2019, refractory or relapsing HL and NHL patients were treated with an autologous HSCT conditioned with cisplatin+dexamethasone as substitution for BCNU in BEAM. Read More

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http://dx.doi.org/10.12659/AOT.918259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824191PMC
October 2019
1 Read

Psychosocial Issues Related to Donor's Decision-Making in Living Donor Liver Transplantation.

Ann Transplant 2019 Oct 18;24:576-583. Epub 2019 Oct 18.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

BACKGROUND The aim of this study was to investigate the detailed motives, concerns, and psychological defensiveness of living liver donor candidates in a Korean population. MATERIAL AND METHODS We analyzed data of 102 donor candidates obtained from routine psychosocial evaluation for living donor liver transplantation (LDLT) using descriptive methods. Donor candidates completed 2 questionnaires regarding their motivations and concerns, as well as a validity scale, the K scale from the Minnesota Multiphasic Personality Inventory-2. Read More

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http://dx.doi.org/10.12659/AOT.916340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820347PMC
October 2019
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Effects of a Structured Physical Activity Program on Serum Adipokines and Markers of Inflammation and Volume Overload in Kidney Transplant Recipients.

Ann Transplant 2019 Oct 8;24:569-575. Epub 2019 Oct 8.

Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Łódź, Łódź, Poland.

BACKGROUND Kidney transplantation (KTx) reverses most abnormalities related to chronic kidney disease (CKD), but sedentary lifestyle persists in most kidney graft recipients. Physical inactivity has been associated with altered adipokine profile and inflammation in CKD. We postulated that increased physical activity achieved through an individually-tailored program can reverse these changes. Read More

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http://dx.doi.org/10.12659/AOT.917047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795104PMC
October 2019
1 Read

Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis.

Ann Transplant 2019 Oct 4;24:553-568. Epub 2019 Oct 4.

Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China (mainland).

BACKGROUND Interstitial fibrosis and tubular atrophy (IF/TA) have been recognized as crucial factors contributing to graft loss resulting from chronic renal allograft injuries. Recent studies have indicated a significant association between the progression of organ fibrosis and single nucleotide polymorphisms (SNPs) found on certain genes. Our research sought to understand these potential associations and detect the potential impact of SNPs on ubiquitin-related genes related to allograft fibrosis in kidney transplant recipients. Read More

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http://dx.doi.org/10.12659/AOT.917767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792502PMC
October 2019
1 Read
1.430 Impact Factor

Pulmonary Infection Within 100 Days After Transplantation Impaired Platelet Recovery in Patients with Hematologic Malignancies: A Propensity-Score-Matched Analysis.

Ann Transplant 2019 Sep 27;24:541-552. Epub 2019 Sep 27.

Department of Hematology, Institute of Hematology, Changhai Hospital, Second Military Medical University, Shanghai, China (mainland).

BACKGROUND Pulmonary infection is one of the life-threatening complications occurring during allogeneic hematopoietic stem cell transplantation (alloHSCT), even when prophylactic measures have been employed. Few studies have investigated whether pulmonary infection affects platelet recovery during alloHSCT. MATERIAL AND METHODS We retrospectively reviewed 253 consecutive patients with hematologic diseases who received alloHSCT in our institute. Read More

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http://dx.doi.org/10.12659/AOT.917802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784627PMC
September 2019
2 Reads
1.430 Impact Factor

Allogenic Tendon-Autologous Cartilage Cells Transplantation Enhances Adhesive/Growth Ability and Promotes Chondrogenesis in a Rabbit Model of Glenoid Labrum Damage.

Ann Transplant 2019 Sep 17;24:532-540. Epub 2019 Sep 17.

Department of Sports Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China (mainland).

BACKGROUND Glenoid labrum injury of the shoulder commonly occurs in athletes, especially those who perform throwing motions. This study investigated the effects of the established allogenic tendon-autologous cartilage cells reconstruction approach in a rabbit model of glenoid labrum damage. MATERIAL AND METHODS The allogenic tendons were isolated and extracted using the chemical extraction method. Read More

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http://dx.doi.org/10.12659/AOT.917518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765340PMC
September 2019
2 Reads
1.430 Impact Factor

Hepatitis B Vaccination in Patients with Liver Cirrhosis Evaluated for Liver Transplantation - A Simple Intervention Ensures High Adherence.

Ann Transplant 2019 Sep 13;24:527-531. Epub 2019 Sep 13.

Clinic for Gastroenterology, University of Leipzig, Leipzig, Germany.

BACKGROUND There is an unmet need to improve the HBV vaccination status in patients with chronic liver diseases. Primary care physicians and outpatient hepatologists often fail to vaccinate as recommended. Thus, new strategies to improve the HBV vaccination rate are required. Read More

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http://dx.doi.org/10.12659/AOT.917198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755938PMC
September 2019
1 Read

A Prospective, Observational Study of Conversion From Immediate- to Prolonged-Release Tacrolimus in Renal Transplant Recipients in France: The OPALE Study.

Ann Transplant 2019 Sep 3;24:517-526. Epub 2019 Sep 3.

Nephrology and Transplantation Unit, Cavale Blanche's Hospital, Brest, France.

BACKGROUND Potential benefits of once-daily, prolonged-release tacrolimus over the immediate-release formulation include improved adherence to immunosuppressives post transplantation. An observational study was performed to characterize real-world practice surrounding conversion from immediate- to prolonged-release tacrolimus in kidney transplant recipients. MATERIAL AND METHODS We performed a prospective, observational study of renal transplant recipients converted from immediate- to prolonged-release tacrolimus capsules. Read More

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http://dx.doi.org/10.12659/AOT.916043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752107PMC
September 2019

A Multicenter, Prospective, Observational Study of Conversion from Twice-Daily Immediate-Release to Once-Daily Prolonged-Release Tacrolimus in Liver Transplant Recipients in France: The COBALT Study.

Ann Transplant 2019 Aug 27;24:506-516. Epub 2019 Aug 27.

Departement of Hepatology, Pontchaillou Hospital, Rennes, France.

BACKGROUND In adult liver transplant patients, the use of prolonged-release tacrolimus may have treatment adherence benefits over the immediate-release formulation. The aim of this study was to characterise real-world practice data on conversion of liver transplant recipients from immediate- to prolonged-release tacrolimus in France. MATERIAL AND METHODS A prospective, observational study (NCT02143479) was conducted in 18 transplant centers in France between June 2014 and March 2016. Read More

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http://dx.doi.org/10.12659/AOT.916041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728630PMC

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: A Single-Center Experience.

Ann Transplant 2019 Aug 23;24:499-505. Epub 2019 Aug 23.

Department of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, Szczecin, Poland.

BACKGROUND There is a worldwide increase in use of liver transplantation (LT) for treatment of hepatocellular carcinoma (HCC). We analyzed our experience with LT for HCC to determine long-term and recurrence-free survival, accuracy of imaging diagnosis of HCC compared to the explant pathology, recurrence rate of HCC, and predictors of recurrence. MATERIAL AND METHODS The whole explant was examined by the same pathologist and compared with the baseline diagnosis established according to clinical, laboratory, and radiological data. Read More

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http://dx.doi.org/10.12659/AOT.918150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717437PMC
August 2019
2 Reads

Prediction of Early Recurrence of Hepatocellular Carcinoma in Patients with Cirrhosis Who Had Received Deceased Donor Liver Transplantation: A Multicenter Study.

Ann Transplant 2019 Aug 20;24:489-498. Epub 2019 Aug 20.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).

BACKGROUND Early recurrence after liver transplantation (LT) is still a clinical problem. This multicenter study evaluated the Milan, Hangzhou, and AFP model-based criteria for prediction of early recurrence of HCC in patients with cirrhosis who had undergone LT. MATERIAL AND METHODS From the China Liver Transplant Registry (CLTR) database, we analyzed data of 589 HCC patients who had undergone LT between Jan 2015 and Jan 2019. Read More

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http://dx.doi.org/10.12659/AOT.917296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713034PMC
August 2019
14 Reads
1.430 Impact Factor

Analysis of Data from the Oxygen Persufflation in Liver Transplantation (OPAL) Study to Determine the Role of Factors Affecting the Hepatic Microcirculation and Early Allograft Dysfunction.

Ann Transplant 2019 Aug 16;24:481-488. Epub 2019 Aug 16.

Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, University Essen-Duisburg, Essen, Germany.

BACKGROUND Adequate microcirculatory perfusion is essential for the provision of oxygen to the liver following transplantation. Data from the Oxygen Persufflation in Liver Transplantation (OPAL) study (ISRCTN00167887) were analyzed from liver transplants performed at a single center to determine the role of factors affecting the hepatic microcirculation and early allograft dysfunction (EAD). MATERIAL AND METHODS Retrospective data from 116 patients from the Oxygen Persufflation as Adjunction in Liver Transplantation (OPAL) study who underwent liver transplantation at a single center were analyzed. Read More

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http://dx.doi.org/10.12659/AOT.915214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708281PMC
August 2019
2 Reads