14,896 results match your criteria Annals of the Rheumatic Diseases[Journal]


Successful treatment of arthritis and rash with tofacitinib in systemic lupus erythematosus: the experience from a single centre.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, National Clinical Research Center on Rheumatology, Ministry of Science & Technology, Beijing, China

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21545
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http://dx.doi.org/10.1136/annrheumdis-2019-215455DOI Listing
April 2019
3 Reads

Smoking does not protect patients with axial spondyloarthritis from attacks of uveitis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Musculoskeletal biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21534
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http://dx.doi.org/10.1136/annrheumdis-2019-215348DOI Listing
April 2019
1 Read

Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Paediatric Rheumatology and Immunology, University of Münster, Münster, Germany

Objectives: The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a 'window of opportunity' to abrogate the development of chronic arthritis. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21505
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http://dx.doi.org/10.1136/annrheumdis-2019-215051DOI Listing
April 2019
1 Read

Blood plasma versus serum: which is right for sampling circulating membrane microvesicles in human subjects?

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Section of Endocrinology, Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1136/annrheumdis-2019-215505DOI Listing

Pathogenic effector functions of ACPA: Where do we stand?

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Medicine, Duke University Medical Center and Medical Research Service, VA Medical Center, Durham, North Carolina, USA.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21533
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http://dx.doi.org/10.1136/annrheumdis-2019-215337DOI Listing
April 2019
1 Read

Response to: 'Idiopathic inflammatory myopathies and antisynthetase syndrome: contribution of antisynthetase antibodies to improve current classification criteria' by Greco .

Ann Rheum Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Internal Medicine 3, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2019-215484DOI Listing
April 2019
4 Reads

All-cause, cause-specific and age-specific standardised mortality ratios of patients with systemic lupus erythematosus in Ontario, Canada over 43 years (1971-2013).

Ann Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Center for Prognosis Studies in the Rheumatic Diseases, Toronto Lupus Clinic, University Health Network, University of Toronto, Toronto, Ontario, Canada

Background: Survival in systemic lupus erythematosus (SLE) has improved substantially in the last 50 years. The aim of the present study was to assess the evolution of the all-cause, cause-specific and age-specific standardised mortality ratios (SMRs) of patients with lupus in Ontario, Canada.

Patients And Methods: Between 1971 and 2013, 1732 patients were followed in the Toronto Lupus Clinic. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214802DOI Listing
April 2019
10.377 Impact Factor

Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial.

Ann Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Service of Infectious Diseases, Hopitaux Universitaires de Geneve, Geneva, Switzerland

Objective: The optimal duration of postsurgical antibiotic therapy for adult native joint bacterial arthritis remains unknown.

Methods: We conducted a prospective, unblinded, randomised, non-inferiority study comparing either 2 or 4 weeks of antibiotic therapy after surgical drainage of native joint bacterial arthritis in adults. Excluded were implant-related infections, episodes without surgical lavage and episodes with a follow-up of less than 2 months. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-215116DOI Listing
April 2019
1 Read

Aortic dilatation in a patient with Takayasu arteritis treated with tocilizumab.

Ann Rheum Dis 2019 Apr 16. Epub 2019 Apr 16.

Unit of Rheumatology, Azienda Unità Sanitaria Locale-IRCCS, Reggio Emilia, Italy.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21545
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http://dx.doi.org/10.1136/annrheumdis-2019-215459DOI Listing
April 2019
1 Read

The world-wide burden of musculoskeletal diseases: a systematic analysis of the World Health Organization Burden of Diseases Database.

Ann Rheum Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Rheumatology - Centre National de Référence des Maladies Systémiques Rares Est Sud-Ouest (RESO), Hôpitaux Universitaires de Strasbourg, Strasbourg, France

Background: Musculoskeletal (MSK) diseases are expected to have a growing impact worldwide.

Objective: To analyse the worldwide burden of MSK diseases from 2000 to 2015.

Methods: Disability-adjusted life years (DALYs), which combines the years of life lost (YLLs) and the years lived with disability (YLDs), were extracted for 183 countries from the WHO Global Health Estimates Database. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-215142DOI Listing

Altered cognitive function in systemic lupus erythematosus and associations with inflammation and functional and structural brain changes.

Ann Rheum Dis 2019 Apr 12. Epub 2019 Apr 12.

Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

Objectives: Cognitive dysfunction (CD) is common in systemic lupus erythematosus (SLE) but the cause remains unclear and treatment options are limited. We aimed to compare cognitive function in SLE and healthy controls (HCs) using both behavioural and neuroimaging techniques.

Methods: Patients with SLE with stable disease and HCs were recruited. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214677DOI Listing
April 2019
1 Read

Are corticosteroid injections needed after needling and lavage of calcific tendinitis? Randomised, double-blind, non-inferiority trial.

Ann Rheum Dis 2019 Apr 11. Epub 2019 Apr 11.

Department of Rheumatology, CHU Nantes, Nantes, France

Objective: Steroid injections are common after an ultrasound-guided puncture and lavage (UGPL) of calcific tendonitis of the rotator cuff. However, steroids may prevent calcification resorption and negatively affect tendon healing. Our study was designed to determine whether saline solution was non-inferior to steroids in the prevention of acute pain reactions in the week following UGPL. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214971DOI Listing
April 2019
1 Read

Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study.

Ann Rheum Dis 2019 Apr 9. Epub 2019 Apr 9.

Rheumatology A Department, Cochin Hospital, APHP, Paris Descartes University, Paris, France.

Objective: To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.

Methods: We performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214816DOI Listing
April 2019
1 Read
10.377 Impact Factor

Aortic-vertebral interaction in ankylosing spondylitis: syndesmophyte development at the juxta-aortic vertebral rim.

Ann Rheum Dis 2019 Apr 6. Epub 2019 Apr 6.

Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

Objectives: The aorta inhibits paravertebral ossification in diffuse idiopathic skeletal hyperostosis. We investigated if syndesmophytes in ankylosing spondylitis (AS) occurred less often at the vertebral rim near the aorta.

Methods: We performed thoracolumbar CT scans in 60 subjects in this cross-sectional study. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214675DOI Listing
April 2019
4 Reads

Gradual tapering TNF inhibitors versus conventional synthetic DMARDs after achieving controlled disease in patients with rheumatoid arthritis: first-year results of the randomised controlled TARA study.

Ann Rheum Dis 2019 Apr 6. Epub 2019 Apr 6.

Rheumatology, Erasmus Medical Centre, Rotterdam, The Netherlands.

Objectives: The aim of this study is to evaluate the effectiveness of two tapering strategies after achieving controlled disease in patients with rheumatoid arthritis (RA), during 1 year of follow-up.

Methods: In this multicentre single-blinded (research nurses) randomised controlled trial, patients with RA were included who achieved controlled disease, defined as a Disease Activity Score (DAS) ≤ 2.4 and a Swollen Joint Count (SJC) ≤ 1, treated with both a conventional synthetic disease-modifying antirheumatic drugs (csDMARD) and a TNF inhibitor. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214970DOI Listing
April 2019
3 Reads

Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan.

Ann Rheum Dis 2019 Apr 6. Epub 2019 Apr 6.

Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan

Objective: Patients with systemic lupus erythematosus (SLE) are susceptible to herpes simplex virus (HSV) infection, which occasionally leads to severe complications including meningoencephalitis and keratitis. However, few attempts to analyse the associated incidence and risk factors have been made.

Methods: We enrolled patients with SLE recorded between 1997 and 2012 and compared the incidence rate (IR) of severe HSV infection, including meningoencephalitis, septicaemia, ocular and visceral involvement, and other specific complications demanding hospitalisation, with that of a non-SLE cohort. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214844DOI Listing
April 2019
2 Reads

Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis.

Ann Rheum Dis 2019 Apr 5. Epub 2019 Apr 5.

Division of Rheumatology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Objectives: Treatment of patients with systemic sclerosis (SSc) can be challenging because of clinical heterogeneity. Integration of genome-scale transcriptomic profiling for patients with SSc can provide insights on patient categorisation and novel drug targets.

Methods: A normalised compendium was created from 344 skin samples of 173 patients with SSc, covering an intersection of 17 424 genes from eight data sets. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214778DOI Listing

Sequencing of the MHC region defines as the major genetic risk for seropositive rheumatoid arthritis in Han Chinese population.

Ann Rheum Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China

Objective: The strong genetic contribution of the major histocompatibility complex (MHC) region to rheumatoid arthritis (RA) has been generally attributed to human leukocyte antigen (. However, due to the high polymorphisms and linkage disequilibrium within MHC, it is difficult to define novel and/or independent genetic risks using conventional HLA genotyping or chip-based microarray technology. This study aimed to identify novel RA risk variants by performing deep sequencing for MHC. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214725DOI Listing
April 2019
2 Reads

Development and validation of the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI): a novel instrument to quantify organ damage in systemic sclerosis.

Ann Rheum Dis 2019 Mar 30. Epub 2019 Mar 30.

Department of Medicine, University of Melbourne at St. Vincent Hospital, Melbourne, Fitzroy, Victoria, Australia

Objective: We sought to develop the first Damage Index (DI) in systemic sclerosis (SSc).

Methods: The conceptual definition of 'damage' in SSc was determined through consensus by a working group of the Scleroderma Clinical Trials Consortium (SCTC). Systematic literature review and consultation with patient partners and non-rheumatologist experts produced a list of potential items for inclusion in the DI. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214764DOI Listing
March 2019
1 Read
10.377 Impact Factor

Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops.

Ann Rheum Dis 2019 Mar 30. Epub 2019 Mar 30.

Molecular Immunology and Inflammation Unit, VIB Center of Inflammatory Research-Ghent University, Ghent, Belgium

Objectives: The mechanisms driving onset of joint inflammation in arthritides such as rheumatoid arthritis and spondyloarthritis and the conversion to disease chronicity are poorly understood. We hypothesised mechanostrain could play an instrumental role herein by engaging local and/or systemic pathways, thereby attenuating disease course and outcome.

Methods: The development of collagen antibody-induced arthritis (CAIA) in C57BL/6 mice was evaluated both clinically and histologically under different loading regimens: control, voluntary running or hindpaw unloading. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214627DOI Listing

2019 update of the EULAR recommendations for the management of systemic lupus erythematosus.

Ann Rheum Dis 2019 Mar 29. Epub 2019 Mar 29.

Rheumatology and Clinical Immunology Unit, "Attikon" University Hospital, Athens, Greece.

Our objective was to update the EULAR recommendations for the management of systemic lupus erythematosus (SLE), based on emerging new evidence. We performed a systematic literature review (01/2007-12/2017), followed by modified Delphi method, to form questions, elicit expert opinions and reach consensus. Treatment in SLE aims at remission or low disease activity and prevention of flares. Read More

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http://dx.doi.org/10.1136/annrheumdis-2019-215089DOI Listing
March 2019
2 Reads

Response to: 'Inflammatory and non-inflammatory triggers of acute coronary syndromes' by Eyuboglu.

Ann Rheum Dis 2019 Mar 28. Epub 2019 Mar 28.

Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/annrheumdis-2019-215293DOI Listing
March 2019
1 Read

CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene.

Ann Rheum Dis 2019 Mar 28. Epub 2019 Mar 28.

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University school of medicine & KeyLaboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang, Hangzhou 310016, China

Objectives: Circular RNAs (circRNA) expression aberration has been identified in various human diseases. In this study, we investigated whether circRNAs could act as competing endogenous RNAs to regulate the pathological process of osteoarthritis (OA).

Methods: CircRNA deep sequencing was performed to the expression of circRNAs between OA and control cartilage tissues. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21478
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http://dx.doi.org/10.1136/annrheumdis-2018-214786DOI Listing
March 2019
14 Reads

Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis.

Ann Rheum Dis 2019 Mar 25. Epub 2019 Mar 25.

Division of Rheumatology, Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada

Objectives: We aimed to identify soluble biomarkers that differentiate psoriatic arthritis (PsA) from osteoarthritis (OA).

Methods: Markers of cartilage metabolism (cartilage oligomeric matrix protein [COMP], hyaluronan), metabolic syndrome (adiponectin, adipsin, resistin, hepatocyte growth factor [HGF], insulin, leptin) and inflammation (C-reactive protein [CRP], interleukin-1β [IL-1β], IL-6, IL-8, tumour necrosis factor alpha [TNFα], monocyte chemoattractant protein-1 [MCP-1], nerve growth factor [NGF]) were compared in serum samples from 201 patients with OA, 77 patients with PsA and 76 controls. Levels across the groups were compared using the Kruskal-Wallis test. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214737DOI Listing
March 2019
1 Read

MRI inflammation of the hand interosseous tendons occurs in anti-CCP-positive at-risk individuals and may precede the development of clinical synovitis.

Ann Rheum Dis 2019 Mar 23. Epub 2019 Mar 23.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK

Interosseous tendon inflammation (ITI) has been described in rheumatoid arthritis (RA). Whether ITI occurs in at-risk individuals before the onset of clinical synovitis is unknown.

Objectives: To investigate, by MRI, ITI in anti-cyclic citrullinated peptide (CCP)-positive at-risk individuals (CCP +at risk) and to describe the anatomy, prevalence and clinical associations across the RA continuum. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214331DOI Listing
March 2019
1 Read

Optimal time between the last methotrexate administration and seasonal influenza vaccination in rheumatoid arthritis: post hoc analysis of a randomised clinical trial.

Ann Rheum Dis 2019 Mar 23. Epub 2019 Mar 23.

Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

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http://dx.doi.org/10.1136/annrheumdis-2019-215187DOI Listing
March 2019
1 Read

Blockade of CD40-CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren's syndrome.

Ann Rheum Dis 2019 Mar 22. Epub 2019 Mar 22.

Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research Basel, Basel, Switzerland

Objective: To examine the role of CD40-CD154 costimulation and effects of therapeutic pathway blockade in the non-obese diabetic (NOD/ShiLtJ) model of Sjögren's syndrome (SS).

Methods: We assessed leucocyte infiltration in salivary glands (SGs) from NOD/ShiLtJ mice by immunohistochemistry and examined transcriptomics data of SG tissue from these animals for evidence of a CD40 pathway gene signature. Additionally, we dosed MR1 (anti-CD154 antibody) in NOD mice after the onset of SS-like disease and examined the effects of MR1 treatment on sialadenitis, autoantibody production, SG leucocyte infiltration, gene expression downstream of CD40 and acquaporin 5 (AQP5) expression. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-213929DOI Listing
March 2019
1 Read

Clinical characteristics of patients with alpha-galactosidase A gene variants in a German multicentre cohort of early undifferentiated arthritis.

Ann Rheum Dis 2019 Mar 22. Epub 2019 Mar 22.

Heinrich-Heine-University Düsseldorf, Medical Faculty, Hiller Research Center & Department of Rheumatology, Düsseldorf, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2019-215223DOI Listing
March 2019
1 Read

Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker parameters in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study.

Ann Rheum Dis 2019 Mar 22. Epub 2019 Mar 22.

Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.

Objective: To evaluate the safety, efficacy and therapeutic mechanism of BI 655064, an antagonistic anti-CD40 monoclonal antibody, in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX-IR).

Methods: In total, 67 patients were randomised to receive weekly subcutaneous doses of 120 mg BI 655064 (n=44) or placebo (n=23) for 12 weeks. The primary endpoint was the proportion of patients who achieved 20% improvement in American College of Rheumatology criteria (ACR20) at week 12. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214729DOI Listing
March 2019
2 Reads

2018 EULAR recommendations for a core data set to support observational research and clinical care in giant cell arteritis.

Ann Rheum Dis 2019 Mar 21. Epub 2019 Mar 21.

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.

Giant cell arteritis (GCA) represents the most common form of primary systemic vasculitis and is frequently associated with comorbidities related to the disease itself or induced by the treatment. Systematically collected data on disease course, treatment and outcomes of GCA remain scarce. The aim of this EULAR Task Force was to identify a core set of items which can easily be collected by experienced clinicians, in order to facilitate collaborative research into the course and outcomes of GCA. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214755DOI Listing
March 2019
1 Read

MYCYC: unravelling the long road ahead in ANCA-associated vasculitis.

Ann Rheum Dis 2019 Mar 20. Epub 2019 Mar 20.

Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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http://dx.doi.org/10.1136/annrheumdis-2019-215241DOI Listing
March 2019
1 Read

Response to: 'MYCYC, unravelling the long road ahead in ANCA-associated vasculitis' by Jain .

Ann Rheum Dis 2019 Mar 20. Epub 2019 Mar 20.

Department of Renal Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1136/annrheumdis-2019-215254DOI Listing
March 2019
1 Read

Differing contribution of methotrexate polyglutamates to adalimumab blood levels as compared with etanercept.

Ann Rheum Dis 2019 Mar 18. Epub 2019 Mar 18.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/annrheumdis-2018-214860DOI Listing

Correction: .

Authors:

Ann Rheum Dis 2019 Mar 18. Epub 2019 Mar 18.

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http://dx.doi.org/10.1136/annrheumdis-2015-208094corr1DOI Listing
March 2019
3 Reads

Correction: .

Authors:

Ann Rheum Dis 2019 Mar 18. Epub 2019 Mar 18.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2015-20809
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http://dx.doi.org/10.1136/annrheumdis-2015-208093corr1DOI Listing
March 2019
5 Reads

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients.

Ann Rheum Dis 2019 Mar 16. Epub 2019 Mar 16.

Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK

Objectives: To unravel the hierarchy of cellular/molecular pathways in the disease tissue of early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship with clinical phenotypes and treatment response/outcomes longitudinally.

Methods: 144 consecutive treatment-naïve early RA patients (<12 months symptoms duration) underwent ultrasound-guided synovial biopsy before and 6 months after disease-modifying antirheumatic drug (DMARD) initiation. Synovial biopsies were analysed for cellular (immunohistology) and molecular (NanoString) characteristics and results compared with clinical and imaging outcomes. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214539DOI Listing

Could autologous adipose-derived stromal vascular fraction turn out an unwanted source of profibrotic myofibroblasts in systemic sclerosis?

Authors:
Mirko Manetti

Ann Rheum Dis 2019 Mar 13. Epub 2019 Mar 13.

Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence I-50134, Italy

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http://dx.doi.org/10.1136/annrheumdis-2019-215288DOI Listing

Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective.

Ann Rheum Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Oral Biology, University of Florida, Gainesville, Florida, USA.

The indirect immunofluorescence assay (IIFA) on HEp-2 cells is widely used for detection of antinuclear antibodies (ANA). The dichotomous outcome, negative or positive, is integrated in diagnostic and classification criteria for several systemic autoimmune diseases. However, the HEp-2 IIFA test has much more to offer: besides the titre or fluorescence intensity, it also provides fluorescence pattern(s). Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21443
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http://dx.doi.org/10.1136/annrheumdis-2018-214436DOI Listing
March 2019
55 Reads

Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis.

Ann Rheum Dis 2019 May 12;78(5):672-675. Epub 2019 Mar 12.

Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK

Objectives: Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis (OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a novel vaccine strategy to generate anti-NGF antibodies for reversal of pain behaviour in a surgical model of OA.

Methods: Virus-like particles were derived from the cucumber mosaic virus (CuMV) and coupled to expressed recombinant NGF to create the vaccine. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214489DOI Listing
May 2019
4 Reads

Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes.

Ann Rheum Dis 2019 May 12;78(5):617-628. Epub 2019 Mar 12.

VIB Center for Brain and Disease Research, Leuven, Belgium

Objectives: Juvenile idiopathic arthritis (JIA) is the most common class of childhood rheumatic diseases, with distinct disease subsets that may have diverging pathophysiological origins. Both adaptive and innate immune processes have been proposed as primary drivers, which may account for the observed clinical heterogeneity, but few high-depth studies have been performed.

Methods: Here we profiled the adaptive immune system of 85 patients with JIA and 43 age-matched controls with indepth flow cytometry and machine learning approaches. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214354DOI Listing
May 2019
3 Reads

Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort.

Ann Rheum Dis 2019 May 9;78(5):648-656. Epub 2019 Mar 9.

Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

Objectives: To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcSSc).

Methods: We evaluated patients from the European Scleroderma Trials and Research database with dcSSc, baseline modified Rodnan skin score (mRSS) ≥7, valid mRSS at 12±3 months after baseline and ≥1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRSS >5 and ≥25% from baseline to 12±3 months. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-213455DOI Listing
May 2019
1 Read

Common mental disorders within chronic inflammatory disorders: a primary care database prospective investigation.

Ann Rheum Dis 2019 May 7;78(5):688-695. Epub 2019 Mar 7.

Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Objective: There is inconsistent evidence about the association between inflammatory disorders and depression and anxiety onset in a primary care context. The study aimed to evaluate the risk of depression and anxiety within multisystem and organ-specific inflammatory disorders.

Methods: This is a prospective cohort study with primary care patients from the UK Clinical Practice Research Datalink diagnosed with an inflammatory disorder between 1 January 2001 and 31 December 2016. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214676DOI Listing
May 2019
2 Reads

Inflammatory and non-inflammatory triggers of acute coronary syndromes.

Authors:
Mehmet Eyuboglu

Ann Rheum Dis 2019 Mar 6. Epub 2019 Mar 6.

Cardiology, Bergama State Hospital, Izmir 35000, Turkey

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http://dx.doi.org/10.1136/annrheumdis-2019-215277DOI Listing

Shared genetic factors and their causality in autoimmune diseases.

Ann Rheum Dis 2019 Mar 6. Epub 2019 Mar 6.

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.

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http://dx.doi.org/10.1136/annrheumdis-2019-215099DOI Listing
March 2019
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