14,830 results match your criteria Annals of the Rheumatic Diseases[Journal]


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Ann Rheum Dis 2019 Mar;78(3):442

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http://dx.doi.org/10.1136/annrheumdis-2018-213396corr1DOI Listing

Response to 'Everything we see is a perspective, not the truth' by Chattopadhyay .

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Rheumatology, Cochin Hospital, Assistance Publique- Hôpitaux de Paris, Paris, France

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http://dx.doi.org/10.1136/annrheumdis-2019-215131DOI Listing
February 2019

Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Centre de Recherche Saint-Antoine (CRSA), Sorbonne Université, INSERM U938, Paris, France

Objectives: Systemic sclerosis (SSc) is an autoimmune disease characterised by widespread fibrosis, microangiopathy and autoantibodies. Follicular helper T (Tfh) cells CD4CXCR5PD-1 cooperate with B lymphocytes to induce the differentiation of plasmocytes secreting immunoglobulins (Ig). Circulating Tfh (cTfh) cells are increased in several autoimmune diseases. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214382DOI Listing
February 2019

in individuals at risk for rheumatoid arthritis.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany

Objectives: Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of spp. in a group of individuals at increased risk for RA, but prior to the development of the disease. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214514DOI Listing
February 2019

[18F]Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

The National Institute for Health Research Manchester Musculoskeletal Biomedical Research Centre, Manchester University Hospitals NHS FoundationTrust, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

Objectives: With the tools available currently, confirming the diagnosis of inclusion body myositis (IBM) can be difficult. Many patients are initially misdiagnosed with polymyositis (PM). In this observational study at a UK adult neuromuscular centre, we investigated whether amyloid positron emission tomography could differentiate between IBM and PM. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214644DOI Listing
February 2019

Evolving and expanding scope of lupus-inducing drugs.

Authors:
Robert L Rubin

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, USA

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http://dx.doi.org/10.1136/annrheumdis-2018-214785DOI Listing
February 2019

'Everything we see is a perspective, not the truth'.

Ann Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Clinical immunology and Rheumatology services, Post Graduate Institute of Medical Education & Research, Chandigarh, Punjab, India.

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http://dx.doi.org/10.1136/annrheumdis-2019-215109DOI Listing
February 2019

Time-dependent biases in observational studies of comparative effectiveness research in rheumatology. A methodological review.

Ann Rheum Dis 2019 Feb 12. Epub 2019 Feb 12.

Methods of Therapeutic Evaluation of Chronic Diseases (METHODS) Team, INSERM, UMR 1153, Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (CRESS), Paris, France.

Objective: To assess to what extent time-dependent biases (ie, immortal time bias (ITB) and time-lag bias (TLB)) occur in the latest rheumatology observational studies, describe their main mechanisms and increase the awareness on this topic.

Methods: We searched PubMed for observational studies on rheumatic diseases published in leading medical journals in the last 5 years. Only studies with a time-to-event analysis exploring the association of one or more interventional strategies with an outcome were included. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214544DOI Listing
February 2019

Changing landscape of immunosuppression in ANCA-associated vasculitis.

Ann Rheum Dis 2019 Feb 12. Epub 2019 Feb 12.

Department of Rheumatology, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russian Federation.

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http://dx.doi.org/10.1136/annrheumdis-2019-215123DOI Listing
February 2019

Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade.

Ann Rheum Dis 2019 Feb 11. Epub 2019 Feb 11.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China

Objectives: Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional relationship in OA progression in chondrocyte lineage. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214200DOI Listing
February 2019

Is retinal microvascular damage an early manifestation of systemic sclerosis?

Ann Rheum Dis 2019 Feb 9. Epub 2019 Feb 9.

School of Medicine, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1136/annrheumdis-2019-215127DOI Listing
February 2019

Risk of venous thromboembolism in ankylosing spondylitis: a general population-based study.

Ann Rheum Dis 2019 Feb 8. Epub 2019 Feb 8.

Division of Rheumatology, Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.

Background: Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), can be life threatening. An increased frequency of VTE has been found in inflammatory conditions. To date, evidence assessing whether this risk is also greater in patients with ankylosing spondylitis (AS) is scarce. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214388DOI Listing
February 2019
2 Reads

Henry G Kunkel and Rheumatoid Factor.

Authors:
Eng M Tan

Ann Rheum Dis 2019 Feb 8. Epub 2019 Feb 8.

Professor emeritus, The Scripps Research Institute, La Jolla, CA 92037, USA

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21489
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http://dx.doi.org/10.1136/annrheumdis-2018-214893DOI Listing
February 2019
3 Reads

Gout is associated with increased healthcare utilization after knee arthroplasty.

Ann Rheum Dis 2019 Feb 2. Epub 2019 Feb 2.

Department of Medicine at School of Medicine, University of Alabama, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1136/annrheumdis-2018-214934DOI Listing
February 2019
2 Reads

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2018.

Ann Rheum Dis 2019 Feb 2. Epub 2019 Feb 2.

Swedish Medical Center, University of Washington, Seattle, Washington, USA.

To develop a comprehensive listing of the greatest unmet scientific and clinical needs in rheumatology. The 20th annual international Targeted Therapies meeting brought more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of five disease-specific groups with 20-30 experts assigned to each group based on expertise. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214280DOI Listing
February 2019
5 Reads

Adipose stromal vascular fraction and regenerative therapy in SSc: response to the article by Magalon .

Ann Rheum Dis 2019 Feb 2. Epub 2019 Feb 2.

Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

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http://dx.doi.org/10.1136/annrheumdis-2019-215113DOI Listing
February 2019

Potential roles for tenascin in (very) early diagnosis and treatment of rheumatoid arthritis.

Ann Rheum Dis 2019 Feb 1. Epub 2019 Feb 1.

Research Laboratories and Academic Division of Rheumatology, Postgraduate School of Rheumatology, Department of Internal Medicine, University of Genova, Polyclinic Hospital San Martino Genova, Genova, Italy.

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http://dx.doi.org/10.1136/annrheumdis-2019-215063DOI Listing
February 2019

Response to 'IgA vasculitis in adults: few certainties and many uncertainties' by Hočevar .

Ann Rheum Dis 2019 Jan 30. Epub 2019 Jan 30.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1136/annrheumdis-2018-214951DOI Listing
January 2019

IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota.

Ann Rheum Dis 2019 Jan 30. Epub 2019 Jan 30.

Faculty of Medicine, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia

Objectives: Certain gut bacterial families, including Bacteroidaceae, Porphyromonadaceae and Prevotellaceae, are increased in people suffering from spondyloarthropathy (SpA), a disease group associated with signalling variants. To understand the relationship between host interleukin (IL)-23 signalling and gut bacterial dysbiosis in SpA, we inhibited IL-23 in dysbiotic ZAP-70-mutant SKG mice that develop IL-23-dependent SpA-like arthritis, psoriasis-like skin inflammation and Crohn's-like ileitis in response to microbial beta 1,3-glucan (curdlan).

Methods: We treated SKG mice weekly with anti-IL-23 or isotype mAb for 3 weeks, rested them for 3 weeks, then administered curdlan or saline. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214381DOI Listing
January 2019

experimentally induces periodontis and an anti-CCP2-associated arthritis in the rat.

Ann Rheum Dis 2019 Jan 30. Epub 2019 Jan 30.

SAINBIOSE, INSERM U1059, University of Lyon, Saint-Etienne, France

Objectives: Association between periodontal disease (PD) and rheumatoid arthritis (RA) has been extensively described, but direct evidence of causal involvement of PD in RA is missing. We investigated the priming role of oral () in PD and subsequent RA and we assessed biomarkers of bone resorption and arthritis development in rats. METHODS : Lewis rats were orally exposed to either , or control gel for 1 month and then followed for 8 months. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-213697DOI Listing
January 2019
2 Reads

Response to: 'Risk of severe infection following rituximab and the efficacy of antimicrobial prophylaxis' by Wallace .

Ann Rheum Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Internal Medicine IV (Nephrology and Hypertension), Anichstraße, Innsbruck, Austria.

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http://dx.doi.org/10.1136/annrheumdis-2019-215036DOI Listing
January 2019

Response to: 'When binary and continuous responses disagree' by Dr Ouyang.

Ann Rheum Dis 2019 Jan 30. Epub 2019 Jan 30.

Division of Rheumatology, Geneva University Hospitals, Geneva, Switzerland

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http://dx.doi.org/10.1136/annrheumdis-2019-215019DOI Listing
January 2019
1 Read

Risk of severe infection following rituximab and the efficacy of antimicrobial prophylaxis.

Ann Rheum Dis 2019 Jan 30. Epub 2019 Jan 30.

Rheumatology Unit, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, USA.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21500
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http://dx.doi.org/10.1136/annrheumdis-2019-215009DOI Listing
January 2019
1 Read

Multicriteria decision analysis process to develop new classification criteria for systemic lupus erythematosus.

Ann Rheum Dis 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

European League Against Rheumatism and are jointly supporting multiphase development of systemic lupus erythematosus (SLE) classification criteria based on weighted criteria and a continuous probability scale. Prior steps included item generation, item reduction and hierarchical organisation of candidate criteria using an evidence-based approach. Our objectives were to determine relative weights using multicriteria decision analysis (MCDA) and to set a provisional threshold score for SLE classification. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21468
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http://dx.doi.org/10.1136/annrheumdis-2018-214685DOI Listing
January 2019
3 Reads

When binary and continuous responses disagree.

Authors:
Fengchen Ouyang

Ann Rheum Dis 2019 Jan 25. Epub 2019 Jan 25.

Retired, Xi'an, Shaanxi, China

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21496
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http://dx.doi.org/10.1136/annrheumdis-2018-214968DOI Listing
January 2019
2 Reads

Short lymphocyte, but not granulocyte, telomere length in a subset of patients with systemic sclerosis.

Ann Rheum Dis 2019 Jan 24. Epub 2019 Jan 24.

Division of Rheumatology, Northwestern Scleroderma Program, Feinberg School of Medicine, Northwestern University, Chicago, USA

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http://dx.doi.org/10.1136/annrheumdis-2018-214499DOI Listing
January 2019
1 Read

PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes.

Ann Rheum Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterised by autoantibody production and widespread inflammation damaging many organs. Previous genome-wide association studies (GWASs) have revealed over 80 genetic determinants of SLE, but they collectively explain a fraction of the heritability, and only a few were proven in vivo for the involvement in SLE. We conducted a meta-analysis of SLE GWAS in the Japanese population, followed by functional analyses of a susceptibility gene with use of mutant mice. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214116DOI Listing
January 2019
2 Reads

Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoid arthritis: a multidatabase cohort study.

Ann Rheum Dis 2019 Jan 24. Epub 2019 Jan 24.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts, USA

Objective: To investigate the rate of serious bacterial, viral or opportunistic infection in patients with rheumatoid arthritis (RA) starting tocilizumab (TCZ) versus tumour necrosis factor inhibitors (TNFi) or abatacept.

Methods: Using claims data from US Medicare from 2010 to 2015, and IMS and MarketScan from 2011 to 2015, we identified adults with RA who initiated TCZ or TNFi (primary comparator)/abatacept (secondary comparator) with prior use of ≥1 different biologic drug or tofacitinib. The primary outcome was hospitalised serious infection (SI), including bacterial, viral or opportunistic infection. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21436
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http://dx.doi.org/10.1136/annrheumdis-2018-214367DOI Listing
January 2019
7 Reads

Lupus Low Disease Activity State (LLDAS) discriminates responders in the BLISS-52 and BLISS-76 phase III trials of belimumab in systemic lupus erythematosus.

Ann Rheum Dis 2019 Jan 24. Epub 2019 Jan 24.

Rheumatology, St Vincent's Hospital, Melbourne, Victoria, Australia

Objective: We evaluated the discriminant capacity of the Lupus Low Disease Activity State (LLDAS) in post-hoc analysis of data from the BLISS-52 and BLISS-76 trials of belimumab in systemic lupus erythematosus (SLE).

Methods: LLDAS attainment, discrimination between belimumab and placebo arms, and the effects in subgroups with high disease activity at recruitment were evaluated at week 52 using appropriate descriptive statistics, χ test and logistic regression.

Results: At week 52, for belimumab 10 mg/kg, 17. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214427DOI Listing
January 2019
10.377 Impact Factor

Individual-level and country-level socioeconomic determinants of disease outcomes in SpA: multinational, cross-sectional study (ASAS-COMOSPA).

Ann Rheum Dis 2019 Jan 23. Epub 2019 Jan 23.

Rheumatology, Maastricht University Medical Center and Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.

Objective: To explore the independent contribution of individual-level and country level socioeconomic status (SES) determinants to disease activity and physical function in patients with spondyloarthritis (SpA).

Methods: Data from the cross-sectional, multinational (n=22 countries worldwide) COMOSPA (COMOrbidities in SpA) study were used. Contribution of individual SES factors (gender, education) and country of residence to Ankylosing Spondylitis Disease Activity Score (ASDAS) and Bath Ankylosing Spondylitis Functional Index (BASFI) was explored in multilevel regression models, adjusting for clinical and demographic confounders. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214259DOI Listing
January 2019
3 Reads

Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: a retrospective analysis of pooled data from 21 clinical trials.

Ann Rheum Dis 2019 Jan 23. Epub 2019 Jan 23.

Novartis Pharma AG, Basel, Switzerland.

Objectives: Here, we present the reported incidence rates of inflammatory bowel disease (IBD) in patients receiving treatment with secukinumab for psoriasis (PsO), psoriatic arthritis (PsA) or ankylosing spondylitis (AS), in a pooled analysis of 21 clinical trials.

Methods: Data from all patients who had received at least one dose of secukinumab were included. Safety analyses were conducted to evaluate cumulative IBD rates as well as per-year rates, by indication. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214273DOI Listing
January 2019
7 Reads

Hypomethylation of and is associated with type-I interferon-dependent expression in lupus CD8+ T cells.

Ann Rheum Dis 2019 Jan 23. Epub 2019 Jan 23.

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

Objective: We examined genome-wide DNA methylation changes in CD8+ T cells from patients with lupus and controls and investigated the functional relevance of some of these changes in lupus.

Methods: Genome-wide DNA methylation of lupus and age, sex and ethnicity-matched control CD8+ T cells was measured using the Infinium MethylationEPIC arrays. Measurement of relevant cell subsets was performed via flow cytometry. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214323DOI Listing
January 2019

Serial IL-6 measurements in patients with tocilizumab-treated large-vessel vasculitis detect infections and may predict early relapses.

Ann Rheum Dis 2019 Jan 22. Epub 2019 Jan 22.

Department of Rheumatology, University Hospital Basel, Basel, Switzerland

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http://dx.doi.org/10.1136/annrheumdis-2018-214704DOI Listing
January 2019
2 Reads

Response to: 'Letter in response to article "Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis"' by Zhou .

Ann Rheum Dis 2019 Jan 18. Epub 2019 Jan 18.

Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Queensland, Australia

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http://dx.doi.org/10.1136/annrheumdis-2018-214765DOI Listing
January 2019
3 Reads

Letter in response to article 'Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis'.

Ann Rheum Dis 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.

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http://dx.doi.org/10.1136/annrheumdis-2018-214708DOI Listing
January 2019
2 Reads

Response to: 'Can solid-phase assays replace immunofluorescence for ANA screening?' by Bizzaro.

Ann Rheum Dis 2019 Jan 18. Epub 2019 Jan 18.

Division of Nephrology, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1136/annrheumdis-2018-214829DOI Listing
January 2019
2 Reads

Clinical trial and 'real-world' data support switching from a bio-originator to its biosimilar.

Ann Rheum Dis 2019 Jan 18. Epub 2019 Jan 18.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2018-214994DOI Listing
January 2019
1 Read

Decreased chance of a live born child in women with rheumatoid arthritis after assisted reproduction treatment: a nationwide cohort study.

Ann Rheum Dis 2019 Mar 12;78(3):328-334. Epub 2019 Jan 12.

Department D, Centre of Andrology and Fertility Clinic, Odense University Hospital, Odense, Denmark.

Objectives: No studies have examined the efficacy of assisted reproductive technology (ART) treatment in women with rheumatoid arthritis. Therefore, we examined the chance of live birth after ART treatment in women with rheumatoid arthritis compared with women without rheumatoid arthritis.

Methods: Our cohort study is based on nationwide Danish health registries, comprising all women with an embryo transfer during 1 January 1994 through 30 June 2017. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21461
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http://dx.doi.org/10.1136/annrheumdis-2018-214619DOI Listing
March 2019
7 Reads

Jan Gösta Waldenström and rheumatology.

Authors:
Frank A Wollheim

Ann Rheum Dis 2019 Jan 12. Epub 2019 Jan 12.

Department of Clinical Sciences Lund, Rheumatology, Medical Faculty, Lund University, Lund 22185, Sweden

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21483
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http://dx.doi.org/10.1136/annrheumdis-2018-214838DOI Listing
January 2019
7 Reads

Verna Wright: father of the spondyloarthropathies.

Ann Rheum Dis 2019 Jan 12. Epub 2019 Jan 12.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK

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http://dx.doi.org/10.1136/annrheumdis-2018-214689DOI Listing
January 2019
1 Read

Current challenges in the development of new treatments for lupus.

Ann Rheum Dis 2019 Jan 12. Epub 2019 Jan 12.

RILITE Research Institute, Charlottesville, Virginia, USA.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a considerable impact on patients' quality of life. Despite the plethora of clinical trials for SLE since the turn of the millennium, only one new treatment has been approved for the condition, and the overall pace of successful drug development remains slow. Nevertheless, the myriad of clinical studies has yielded insights that have informed and refined our understanding of eligibility criteria, outcome measures and trial design in SLE. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214530DOI Listing
January 2019
7 Reads

Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis.

Ann Rheum Dis 2019 Mar 9;78(3):350-354. Epub 2019 Jan 9.

Molecular Rheumatology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

Objective: This study examines polyfunctional T-cells in psoriatic arthritis (PsA) synovial tissue and their associations with clinical disease and implications for therapy.

Methods: PsA synovial tissue was enzymatically/mechanically digested to generate synovial tissue single cell suspensions. Frequencies of polyfunctional CD4, CD8, T-helper 1 (Th1), Th17 and exTh17 cells, using CD161 as a marker of Th17 plasticity, were determined by flow cytometry in matched PsA synovial tissue and peripheral blood. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214138DOI Listing
March 2019
2 Reads