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    48345 results match your criteria Annals of the New York Academy of Sciences[Journal]

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    Diabetes-mediated myelopoiesis and the relationship to cardiovascular risk.
    Ann N Y Acad Sci 2017 Aug;1402(1):31-42
    Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York.
    Diabetes is the greatest risk factor for the development of cardiovascular disease, which, in turn, is the most prevalent cause of mortality and morbidity in diabetics. These patients have elevations in inflammatory monocytes, a factor consistently reported to drive the development of atherosclerosis. In preclinical models of both type 1 and type 2 diabetes, studies have demonstrated that the increased production and activation of monocytes is driven by enhanced myelopoiesis, promoted by factors, including hyperglycemia, impaired cholesterol efflux, and inflammasome activation, that affect the proliferation of bone marrow precursor cells. Read More

    Skeletal fragility in diabetes.
    Ann N Y Acad Sci 2017 Aug;1402(1):18-30
    Metabolic Bone Disease Unit, Columbia University, New York, New York.
    Fracture risk is heightened in patients with both type 1 diabetes (T1D) and type 2 diabetes (T2D). Although bone mineral density by dual-energy X-ray absorptiometry is decreased in T1D, it is paradoxically increased with T2D. To predict fracture risk, the Fracture Risk Assessment Tool (FRAX) can be used in diabetes patients, albeit with refinement. Read More

    Chronic kidney disease and vitamin D metabolism in human bone marrow-derived MSCs.
    Ann N Y Acad Sci 2017 Aug;1402(1):43-55
    Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
    Vitamin D that is synthesized in the skin or is ingested undergoes sequential steps of metabolic activation via a cascade of cytochrome P450 enzymatic hydroxylations in the liver and kidney to produce 1α,25-dihydroxyvitamin D (1α,25(OH)2 D). There are many tissues that are able to synthesize 1α,25(OH)2 D, but the biological significance of extrarenal hydroxylases is unresolved. Human marrow-derived mesenchymal stem cells (marrow stromal cells, hMSCs) give rise to osteoblasts, and their differentiation is stimulated by 1α,25(OH)2 D. Read More

    WHO standards for biotherapeutics, including biosimilars: an example of the evaluation of complex biological products.
    Ann N Y Acad Sci 2017 Sep 14. Epub 2017 Sep 14.
    The Farthings, Kingston upon Thames, UK.
    The most advanced regulatory processes for complex biological products have been put in place in many countries to provide appropriate regulatory oversight of biotherapeutic products in general, and similar biotherapeutics in particular. This process is still ongoing and requires regular updates to national regulatory requirements in line with scientific developments and up-to-date standards. For this purpose, strong knowledge of and expertise in evaluating biotherapeutics in general and similar biotherapeutic products, also called biosimilars, in particular is essential. Read More

    Thiamine content of F-75 therapeutic milk for complicated severe acute malnutrition: time for a change?
    Ann N Y Acad Sci 2017 Sep 14. Epub 2017 Sep 14.
    Pediatric Neurology Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Since community-based management of severe acute malnutrition has become the standard of care, the clinical profile of severe acutely malnourished patients admitted to hospitals or inpatient therapeutic feeding centers has changed significantly. These patients are usually very ill and often present with several comorbidities, such as shock, sepsis, and pneumonia. Complicated severe acute malnutrition patients are at risk of thiamine insufficiency, and critically ill patients have higher thiamine requirements. Read More

    Mechanical signals protect stem cell lineage selection, preserving the bone and muscle phenotypes in obesity.
    Ann N Y Acad Sci 2017 Sep 11. Epub 2017 Sep 11.
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York.
    The incidence of obesity is rapidly rising, increasing morbidity and mortality rates worldwide. Associated comorbidities include type 2 diabetes, heart disease, fatty liver disease, and cancer. The impact of excess fat on musculoskeletal health is still unclear, although it is associated with increased fracture risk and a decline in muscular function. Read More

    Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease.
    Ann N Y Acad Sci 2017 Aug;1401(1):37-48
    State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR, China.
    Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that includes Crohn's disease (CD) and ulcerative colitis (UC). Homeostasis of various regulatory factors involved with intestinal immunity is disrupted in IBD, including the intestinal epithelial barrier, macrophages, and cellular mediators such as cytokines and chemokines. No successful treatment is currently available for the management of IBD. Read More

    Regulation of the tumor suppressor PTEN by natural anticancer compounds.
    Ann N Y Acad Sci 2017 Aug;1401(1):136-149
    Department of Food Science and Biotechnology, College of Knowledge-Based Services Engineering, Sungshin Women's University, Seoul, South Korea.
    The tumor suppressor phosphatase and tensin homologue (PTEN) has phosphatase activity, with phosphatidylinositol (3,4,5)-trisphosphate (PIP3), a product of phosphatidylinositol 3-kinase (PI3K), as one of the principal substrates. PTEN is a negative regulator of the Akt pathway, which plays a fundamental role in controlling cell growth, survival, and proliferation. Loss of PTEN function has been observed in many different types of cancer. Read More

    Tocotrienols for bone health: a translational approach.
    Ann N Y Acad Sci 2017 Aug;1401(1):150-165
    Department of Pharmacology, Universiti Kebangasaan Malaysia, Kuala Lumpur, Malaysia.
    Osteoporosis, a degenerative bone disease, is characterized by low bone mass and microstructural deterioration of bone tissue resulting in aggravated bone fragility and susceptibility to fractures. The trend of extended life expectancy is accompanied by a rise in the prevalence of osteoporosis and concomitant complications in the elderly population. Epidemiological evidence has shown an association between vitamin E consumption and the prevention of age-related bone loss in elderly women and men. Read More

    Plant non-starch polysaccharides that inhibit key enzymes linked to type 2 diabetes mellitus.
    Ann N Y Acad Sci 2017 Aug;1401(1):28-36
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
    Type 2 diabetes mellitus (T2DM), a metabolic disease becoming ever more common, is the result of disturbed glyco- and lipid metabolism. On the basis of their inhibitory effects against several key enzymes linked to T2DM, synthetic antidiabetic agents have been developed and used for diabetic therapy, some with adverse side effects. Fortunately, many plant non-starch polysaccharides (NSPs) have been shown to possess inhibitory effects on the same T2DM-related enzymes. Read More

    Natural products to prevent drug resistance in cancer chemotherapy: a review.
    Ann N Y Acad Sci 2017 Aug;1401(1):19-27
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
    Chemotherapy is the standard internal medical treatment for cancer. However, the resistance of cancer cells to nearly all kinds of chemotherapeutic drugs and targeted drugs has become prevalent, and approximately 80-90% of deaths in cancer patients are directly or indirectly attributed to drug resistance. The progress of new drug research and development has also been impeded by the occurrence of drug resistance, which has emerged as a considerable challenge in cancer therapy. Read More

    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review.
    Ann N Y Acad Sci 2017 Aug;1401(1):102-113
    Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, Guangdong, China.
    Cancer is a primary public health problem and the second leading cause of death worldwide. It causes life-threatening malignancies and results in high financial costs for both patients and the healthcare system. Hence, it is important to develop effective long-term strategies pertaining to prevention and control of cancers. Read More

    Endoluminal weight loss and metabolic therapies: current and future techniques.
    Ann N Y Acad Sci 2017 Sep 8. Epub 2017 Sep 8.
    Division of Gastroenterology and Hepatology, Johns Hopkins Medicine, Baltimore, Maryland.
    Obesity is a public health epidemic associated with a number of comorbidities, most notably type 2 diabetes and hypertension, as well as elevated all-cause mortality. The treatment for obesity and its associated comorbidities has most recently expanded into the field of bariatric endoscopy. This field bridges a gap between lifestyle counseling with or without pharmaceutical treatment and the most effective treatment of obesity, bariatric surgery. Read More

    Site-specific distribution of claudin-based paracellular channels with roles in biological fluid flow and metabolism.
    Ann N Y Acad Sci 2017 Sep 4. Epub 2017 Sep 4.
    Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan.
    The claudins are a family of membrane proteins with at least 27 members in humans and mice. The extracellular regions of claudin proteins play essential roles in cell-cell adhesion and the paracellular barrier functions of tight junctions (TJs) in epithelial cell sheets. Furthermore, the extracellular regions of some claudins function as paracellular channels in the paracellular barrier that allow the selective passage of water, ions, and/or small organic solutes across the TJ in the extracellular space. Read More

    Insulin regulation of gluconeogenesis.
    Ann N Y Acad Sci 2017 Sep 3. Epub 2017 Sep 3.
    Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
    The coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose concentrations. The liver contributes significantly to this process by altering the levels of hepatic glucose release, through controlling the processes of de novo glucose production (gluconeogenesis) and glycogen breakdown (glycogenolysis). Various nutritional and hormonal stimuli signal to alter hepatic gluconeogenic flux, and suppression of this metabolic pathway during the postprandial state can, to a significant extent, be attributed to insulin. Read More

    Mechanisms of weight loss and improved metabolism following bariatric surgery.
    Ann N Y Acad Sci 2017 Sep 3. Epub 2017 Sep 3.
    Research and Clinic Divisions, Joslin Diabetes Center, Boston, Massachusetts.
    Bariatric surgery is increasingly recognized as one of the most effective interventions to help patients achieve significant and sustained weight loss, as well as improved metabolic and overall health. Unfortunately, the cellular and physiological mechanisms by which bariatric surgery achieves weight loss have not been fully elucidated, yet are critical to understanding the central role of the intestinal tract in whole-body metabolism and to developing novel strategies for the treatment of obesity. In this review, we provide an overview of potential mechanisms contributing to weight loss, including effects on regulation of energy balance and both central and peripheral nervous system regulation of appetite and metabolism. Read More

    Resveratrol in the foodomics era: 1:25,000.
    Ann N Y Acad Sci 2017 Sep 3. Epub 2017 Sep 3.
    Chemometrics and Analytical Technology, Department of Food Science, University of Copenhagen, Frederiksberg, Denmark.
    Resveratrol is probably the most investigated plant secondary metabolite ever. An epidemiological study known as the French paradox showed a correlation between red wine intake and low mortality due to coronary heart diseases, and the red wine substance resveratrol was claimed to play a key role. Since then, several hundred resveratrol studies have been conducted to demonstrate its antioxidant and other beneficial properties. Read More

    Therapeutic applications of resveratrol and its derivatives on periodontitis.
    Ann N Y Acad Sci 2017 Aug 30. Epub 2017 Aug 30.
    Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan.
    Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time-consuming. Recently, herbal medicines have been considered for use in treating inflammation-related diseases, including periodontitis. Read More

    Gnetin-C and other resveratrol oligomers with cancer chemopreventive potential.
    Ann N Y Acad Sci 2017 Aug 30. Epub 2017 Aug 30.
    Department of Physical Therapy, School of Health Sciences, Kanazawa University, Kanazawa, Japan.
    Resveratrol has been extensively studied to investigate its biological effects, including its chemopreventive potential against cancer. Over the past decade, various resveratrol oligomers, both naturally occurring and synthetic, have been described. These resveratrol oligomers result from the polymerization of two or more resveratrol units to form dimers, trimers, tetramers, or even more complex derivatives. Read More

    Regulation of claudin-4 via p63 in human epithelial cells.
    Ann N Y Acad Sci 2017 Aug 30. Epub 2017 Aug 30.
    Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Japan.
    P63 is a regulator of cell-cell junction complexes in the epidermis. Claudin-4 is regulated via various factors in normal epithelial cells and diseases. We found that claudin-4 was directly regulated via p63 (TAp63 and ΔNp63) in human keratinocytes and nasal epithelial cells. Read More

    The grapes and wrath: using resveratrol to treat the pathophysiology of hemorrhagic shock.
    Ann N Y Acad Sci 2017 Aug 27. Epub 2017 Aug 27.
    Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    Resveratrol, a naturally occurring polyphenol found in grapes, has been shown to reduce oxidative stress and inflammation in a variety of conditions. Recently, resveratrol has been investigated as a potential adjunct to resuscitation therapy for hemorrhagic shock-a condition characterized by tissue hypoxia, mitochondrial dysfunction, and inflammation. Although standard resuscitation restores tissue perfusion, it can exacerbate oxidative stress and organ damage. Read More

    Mechanobiology of limb musculoskeletal development.
    Ann N Y Acad Sci 2017 Aug 22. Epub 2017 Aug 22.
    Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York.
    While there has been considerable progress in identifying molecular regulators of musculoskeletal development, the role of physical forces in regulating induction, differentiation, and patterning events is less well understood. Here, we highlight recent findings in this area, focusing primarily on model systems that test the mechanical regulation of skeletal and tendon development in the limb. We also discuss a few of the key signaling pathways and mechanisms that have been implicated in mechanotransduction and highlight current gaps in knowledge and opportunities for further research in the field. Read More

    Coagulation and fibrinolysis in gastric cancer.
    Ann N Y Acad Sci 2017 Aug 22. Epub 2017 Aug 22.
    Facility of Bio-Proteomics, Immunopathology and Cancer Biomarkers, CRO Aviano National Cancer Institute, Aviano (PN), Italy.
    Coagulation is a highly conserved process occurring after an injury to a blood vessel and resulting in hemostasis. In the thrombus microenvironment, finely orchestrated events restore vessel integrity through platelet activation, adhesion, and aggregation (primary hemostasis), followed by the coagulation cascades, thrombin generation, and fibrin clot deposition (secondary hemostasis). Several studies on cancer have provided insight into dramatic changes to coagulation-related events (i. Read More

    Exploring spatially varying relationships between children's lead poisoning and environmental factors.
    Ann N Y Acad Sci 2017 Aug 22. Epub 2017 Aug 22.
    School of Forestry, Northeast Forestry University (NEFU), Harbin, Heilongjiang, People's Republic of China.
    Children's lead poisoning continues to compromise children's health and development, particularly in the inner cities of the United States. We applied a global Poisson model, a Poisson with random effects model, and a geographically weighted Poisson regression (GWPR) model to deal with the spatial dependence and heterogeneity of the number of children's lead poisoning cases in Syracuse, New York. We used three environmental factors-the building year (i. Read More

    Resveratrol for Alzheimer's disease.
    Ann N Y Acad Sci 2017 Aug 16. Epub 2017 Aug 16.
    Memory Disorders Program, Department of Neurology, Georgetown University, Washington, DC.
    The amyloid hypothesis suggests that the progressive accumulation and deposition of central nervous system (CNS) amyloid with aging is the proximate cause of Alzheimer's disease (AD). Thus, targeting molecular mechanisms of aging may be a viable treatment approach. Caloric restriction prevents diseases of aging, including AD, in animal models, perhaps by activation of sirtuins. Read More

    Dreamless: the silent epidemic of REM sleep loss.
    Ann N Y Acad Sci 2017 Aug 15. Epub 2017 Aug 15.
    The University of Arizona Center for Integrative Medicine, Tucson, Arizona.
    We are at least as dream deprived as we are sleep deprived. Many of the health concerns attributed to sleep loss result from a silent epidemic of REM sleep deprivation. REM/dream loss is an unrecognized public health hazard that silently wreaks havoc with our lives, contributing to illness, depression, and an erosion of consciousness. Read More

    T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells.
    Ann N Y Acad Sci 2017 Aug 14. Epub 2017 Aug 14.
    Division of Biomedical Sciences, University of California, Riverside, California.
    T cell protein tyrosine phosphatase (TCPTP) dephosphorylates a number of substrates, including JAK-STAT (signal transducer and activator of transcription) signaling proteins, which are activated by interferon (IFN)-γ, a major proinflammatory cytokine involved in conditions such as inflammatory bowel disease. A critical function of the intestinal epithelium is formation of a selective barrier to luminal contents. The structural units of the epithelium that regulate barrier function are the tight junctions (TJs), and the protein composition of the TJ determines the tightness of the barrier. Read More

    Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain.
    Ann N Y Acad Sci 2017 Aug 10. Epub 2017 Aug 10.
    Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York.
    Orthopedic research into chronic discogenic back pain has commonly focused on aging- and degeneration-related changes in intervertebral disc structure, biomechanics, and biology. However, the primary spine-related reason for physician office visits is pain. The ambiguous nature of the human condition of discogenic low back pain motivates the use of animal models to better understand the pathophysiology. Read More

    Antiobesity effects of resveratrol: which tissues are involved?
    Ann N Y Acad Sci 2017 Aug 10. Epub 2017 Aug 10.
    Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), Vitoria, Spain.
    The prevalence of obesity has been increasing in recent decades and is reaching epidemic proportions. The current options for overweight and obesity management are energy restriction and physical activity. However, compliance with these treatments is frequently poor and less successful than expected. Read More

    Not all about sex: neural and biobehavioral functions of human dance.
    Ann N Y Acad Sci 2017 Jul;1400(1):8-32
    Department of Psychology, University of the Balearic Islands, Palma, Spain.
    This paper provides an integrative review of neuroscientific and biobehavioral evidence about the effects of dance on the individual across cultural differences. Dance moves us, and many derive aesthetic pleasure from it. However, in addition-and beyond aesthetics-we propose that dance has noteworthy, deeper neurobiological effects. Read More

    Recent developments in understanding the role of the gut microbiota in brain health and disease.
    Ann N Y Acad Sci 2017 Aug 2. Epub 2017 Aug 2.
    APC Microbiome Institute, University College Cork, Cork, Ireland.
    There is a growing appreciation of the role of the gut microbiota in all aspects of health and disease, including brain health. Indeed, roles for the bacterial commensals in various psychiatric and neurological conditions, such as depression, autism, stroke, Parkinson's disease, and Alzheimer's disease, are emerging. Microbiota dysregulation has been documented in all of these conditions or in animal models thereof. Read More

    Deciphering adipose tissue heterogeneity.
    Ann N Y Acad Sci 2017 Aug 1. Epub 2017 Aug 1.
    Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts.
    Obesity is an excess accumulation of adipose tissue mass, and, together with its sequelae, in particular type II diabetes and metabolic syndrome, obesity presents a major health crisis. Although obesity is simply caused by increased adipose mass, the heterogeneity of adipose tissue in humans means that the response to increased energy balance is highly complex. Individual subjects with similar phenotypes may respond very differently to the same treatments; therefore, obesity may benefit from a personalized precision medicine approach. Read More

    Preparation-related structural diversity and medical potential in the treatment of diabetes mellitus with ginseng pectins.
    Ann N Y Acad Sci 2017 Aug 1;1401(1):75-89. Epub 2017 Aug 1.
    School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, Hong Kong, P.R. China.
    Pectins isolated from Panax ginseng C.A. Meyer are potential therapeutic agents for the treatment of diabetes mellitus, a global health challenge. Read More

    Apical cytoskeletons and junctional complexes as a combined system in epithelial cell sheets.
    Ann N Y Acad Sci 2017 Aug 1. Epub 2017 Aug 1.
    Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan.
    Epithelial cell sheet formation is central to many aspects of vertebrate development and function. For example, it is a major principle of differentiation in embryogenesis and regeneration, enables the compartmentalization of tissues, and is the basis for the maintenance of homeostasis throughout the body. A key characteristic of biologically functional epithelial cell sheets is a clear difference between the top and bottom sides owing to the apicobasal polarity of the cells in the sheet, as seen in the simple polar epithelia. Read More

    Muscle-bone interactions: movement in the field of mechano-humoral coupling of muscle and bone.
    Ann N Y Acad Sci 2017 Aug 1;1402(1):10-17. Epub 2017 Aug 1.
    National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York.
    Cyclical, mechanical loading of bone by skeletal muscle is widely recognized as a critical determinant of bone structure and mass. A growing body of evidence indicates that substances released from skeletal muscle into the bloodstream also regulate bone mass and metabolism. In this commentary, we discuss the status of research in the area of humoral regulation of bone mass by the skeletal muscle secretome, with an emphasis on the roles of myostatin, irisin, interleukin-6, and exosomes. Read More

    Mechanisms of action of nonpeptide hormones on resveratrol-induced antiproliferation of cancer cells.
    Ann N Y Acad Sci 2017 Jul 31. Epub 2017 Jul 31.
    Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei, Taiwan.
    Nonpeptide hormones, such as thyroid hormone, dihydrotestosterone, and estrogen, have been shown to stimulate cancer proliferation via different mechanisms. Aside from their cytosolic or membrane-bound receptors, there are receptors on integrin αv β3 for nonpeptide hormones. Interaction between hormones and integrin αv β3 can induce signal transduction and eventually stimulate cancer cell proliferation. Read More

    What is "the unconscious," and where is it located in the brain? A neuropsychoanalytic perspective.
    Ann N Y Acad Sci 2017 Jul 31. Epub 2017 Jul 31.
    Department of Psychology, University of Cape Town, Rondebosch, South Africa.
    This is a brief overview of my "neuropsychoanalytic" perspective on the unconscious. It should make clear how much psychoanalysis has to gain from incorporating the findings of neuroscientific disciplines studying the same part of nature-the workings of the human mind. I hope it makes equally clear what useful new perspectives can be cast on current issues in cognitive neuroscience, if they, in turn, incorporate the findings of psychoanalysis. Read More

    Blood-spinal cord barrier breakdown and pericyte deficiency in peripheral neuropathy.
    Ann N Y Acad Sci 2017 Jul 28. Epub 2017 Jul 28.
    Department of Anesthesiology and Critical Care, University Hospital of Würzburg, Würzburg, Germany.
    The blood-spinal cord barrier (BSCB) prevents leakage of molecules, such as pronociceptive mediators, into the spinal cord, but its role in the pathophysiology of neuropathic pain is not completely understood. Rats with chronic constriction injury (CCI) develop mechanical allodynia, thermal hypersensitivity, and reduced motor performance (Rota-Rod test) compared with sham-injured mice-similar to mice with spared nerve injury (SNI). The BSCB becomes permeable for small and large tracers 1 day after nerve ligation. Read More

    Biphasic influence of Staphylococcus aureus on human epidermal tight junctions.
    Ann N Y Acad Sci 2017 Jul 28. Epub 2017 Jul 28.
    Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Bacterial infections (e.g., with Staphylococcus aureus) are serious problems in skin with a compromised barrier, such as in patients with atopic dermatitis. Read More

    A comprehensive review of agrimoniin.
    Ann N Y Acad Sci 2017 Aug 21;1401(1):166-180. Epub 2017 Jul 21.
    Department of Pharmacognosy, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, Białystok, Poland.
    Plant tannins are a unique class of polyphenols with relatively high molecular weights. Within the ellagitannins group, agrimoniin--dimeric ellagitannin--is one of the most representative compounds found in many plant materials belonging to the Rosaceae family. Agrimoniin was first isolated in 1982 from roots of Agrimonia pilosa Ledeb. Read More

    International summit on the nutrition of adolescent girls and young women: consensus statement.
    Ann N Y Acad Sci 2017 Jul 19;1400(1):3-7. Epub 2017 Jul 19.
    Department of Medicine, Knight Cardiovascular Institute, Center for Developmental Health, Moore Institute for Nutrition & Wellness, Oregon Health & Science University, Portland, Oregon.
    An international summit focusing on the difficult challenge of providing adequate nutrition for adolescent girls and young women in low- and middle-income countries was held in Portland, Oregon in 2015. Sixty-seven delegates from 17 countries agreed on a series of recommendations that would make progress toward improving the nutritional status of girls and young women in countries where their access to nutrition is compromised. Delegate recommendations include: (1) elevate the urgency of nutrition for girls and young women to a high international priority, (2) raise the social status of girls and young women in all regions of the world, (3) identify major knowledge gaps in the biology of adolescence that could be filled by robust research efforts, (4) and improve access to nutrient-rich foods for girls and young women. Read More

    A novel framework for analyzing conservation impacts: evaluation, theory, and marine protected areas.
    Ann N Y Acad Sci 2017 Jul;1399(1):93-115
    Asia-Pacific Program, The Nature Conservancy, Honolulu, Hawaii.
    Environmental conservation initiatives, including marine protected areas (MPAs), have proliferated in recent decades. Designed to conserve marine biodiversity, many MPAs also seek to foster sustainable development. As is the case for many other environmental policies and programs, the impacts of MPAs are poorly understood. Read More

    Characterizing a mouse model for evaluation of countermeasures against hydrogen sulfide-induced neurotoxicity and neurological sequelae.
    Ann N Y Acad Sci 2017 Jul 18;1400(1):46-64. Epub 2017 Jul 18.
    Department of Veterinary Diagnostic and Animal Production Medicine, Iowa State University, Ames, Iowa.
    Hydrogen sulfide (H2 S) is a highly neurotoxic gas. It is the second most common cause of gas-induced deaths. Beyond mortality, surviving victims of acute exposure may suffer long-term neurological sequelae. Read More

    How to select a nanosimilar.
    Ann N Y Acad Sci 2017 Jul 17. Epub 2017 Jul 17.
    Vifor Pharma Ltd., Glattbrugg, Switzerland.
    Nanomedicines in the class of nonbiological complex drugs (NBCDs) are becoming increasingly available. Up to 23 nanomedicines have been approved, and approximately 50 are in clinical development. Meanwhile, the first nanosimilars have entered the market through the generic approval pathway, but clinical differences have been observed. Read More

    Winter storm intensity, hazards, and property losses in the New York tristate area.
    Ann N Y Acad Sci 2017 Jul 17;1400(1):65-80. Epub 2017 Jul 17.
    Lamont-Doherty Earth Observatory, Columbia University, Palisades, New York.
    Winter storms pose numerous hazards to the Northeast United States, including rain, snow, strong wind, and flooding. These hazards can cause millions of dollars in damages from one storm alone. This study investigates meteorological intensity and impacts of winter storms from 2001 to 2014 on coastal counties in Connecticut, New Jersey, and New York and underscores the consequences of winter storms. Read More

    Assessing musical ability quickly and objectively: development and validation of the Short-PROMS and the Mini-PROMS.
    Ann N Y Acad Sci 2017 Jul 13;1400(1):33-45. Epub 2017 Jul 13.
    Department of Psychology, University of Innsbruck, Innsbruck, Austria.
    The study of musical ability has gained considerable traction across disciplines in recent years. In comparison, less effort has been invested in the development of sound measures of musical ability. To redress this gap, we conducted four studies to empirically validate two brief measures derived from the Profile of Music Perception Skills (PROMS)-an exceptionally inclusive battery of musical abilities that takes about 1 h to complete. Read More

    Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance.
    Ann N Y Acad Sci 2017 Jul 12. Epub 2017 Jul 12.
    Centro de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes, Santiago, Chile.
    Since they were first described, mesenchymal stem cells (MSCs) have been shown to have important effector mechanisms and the potential for use in cell therapy. A great deal of research has been focused on unveiling how MSCs contribute to anti-inflammatory responses, including describing several cell populations involved and identifying soluble and other effector molecules. In this review, we discuss some of the contemporary evidence for use of MSCs in the field of immune tolerance, with a special emphasis on transplantation. Read More

    Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients.
    Ann N Y Acad Sci 2017 Jun;1398(1):108-119
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China.
    Cucurbit[7]uril (CB[7]), belonging to the cucurbit[n]uril family (CB[n], n = 5-8, 10, or 13-15), may form host-guest complexes with a variety of small molecules of biomedical interest. The physical and chemical properties of the complexed drugs are often improved as a result of this complexation, suggesting the potential application of CB[7] as a pharmaceutical excipient. This review has summarized the most recent research progress reported between 2011 and early 2017 regarding the biocompatibility of CB[7] and the influence of CB[7] on the stability, solubility, biouptake, and biological activities (including therapeutic efficacies and toxicities) of guest drug molecules. Read More

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