48,946 results match your criteria Annals of the New York Academy of Sciences[Journal]


The role of melatonin in targeting cell signaling pathways in neurodegeneration.

Ann N Y Acad Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Cellular and Structural Biology, University of Texas Health Science Center San Antonio, San Antonio, Texas.

Neurodegenerative diseases are typified by neuronal loss associated with progressive dysfunction and clinical presentation. Neurodegenerative diseases are characterized by the intra- and extracellular conglomeration of misfolded proteins that occur because of abnormal protein dynamics and genetic manipulations; these trigger processes of cell death in these disorders. The disrupted signaling mechanisms involved are oxidative stress-mediated mitochondrial and calcium signaling deregulation, alterations in immune and inflammatory signaling, disruption of autophagic integrity, proteostasis dysfunction, and anomalies in the insulin, Notch, and Wnt/β-catenin signaling pathways. Read More

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http://dx.doi.org/10.1111/nyas.14005DOI Listing
February 2019

Lymphocytic esophagitis updated.

Authors:
Carlos A Rubio

Ann N Y Acad Sci 2019 Jan 17. Epub 2019 Jan 17.

Gastrointestinal and Liver Research Laboratory, Karolinska Institute and University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1111/nyas.14001DOI Listing
January 2019
1 Read

Measurement and interpretation of hemoglobin concentration in clinical and field settings: a narrative review.

Ann N Y Acad Sci 2019 Jan 16. Epub 2019 Jan 16.

Food, Nutrition and Health, University of British Columbia, Vancouver, British Columbia, Canada.

Anemia affects over 800 million women and children globally. Defined as a limited or insufficient functional red blood cell supply in peripheral blood, anemia causes a reduced oxygen supply to tissues and can have serious health consequences for women and children. Hemoglobin (Hb) concentration is most commonly measured for anemia diagnosis. Read More

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http://dx.doi.org/10.1111/nyas.14003DOI Listing
January 2019
1 Read

Physiologic and pathologic effects of dietary free fatty acids on cells of the joint.

Ann N Y Acad Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Orthopaedic Surgery, Washington University, St. Louis, Missouri.

Fatty acids (FAs) are potent organic compounds that not only can be used as an energy source during nutrient deprivation but are also involved in several essential signaling cascades in cells. Therefore, a balanced intake of different dietary FAs is critical for the maintenance of cellular functions and tissue homeostasis. A diet with an imbalanced fat composition creates a risk for developing metabolic syndrome and various musculoskeletal diseases, including osteoarthritis (OA). Read More

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http://dx.doi.org/10.1111/nyas.13999DOI Listing
January 2019
2 Reads

PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes.

Ann N Y Acad Sci 2019 Jan 15. Epub 2019 Jan 15.

Neurology and Research Services, New Mexico VA Healthcare System, Albuquerque, New Mexico.

Receptor-type protein tyrosine phosphatase, receptor type D (PTPRD) has likely roles as a neuronal cell adhesion molecule and synaptic specifier. Interest in its neurobiology and genomics has been stimulated by results from human genetics and mouse models for phenotypes related to addiction, restless leg syndrome, neurofibrillary pathology in Alzheimer's disease, cognitive impairment/intellectual disability, mood lability, and obsessive-compulsive disorder. We review PTPRD's discovery, gene family, candidate homomeric and heteromeric binding partners, phosphatase activities, brain distribution, human genetic associations with nervous system phenotypes, and mouse model data relevant to these phenotypes. Read More

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http://doi.wiley.com/10.1111/nyas.14002
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http://dx.doi.org/10.1111/nyas.14002DOI Listing
January 2019
4 Reads

Species-specific inhibition of antiviral protein kinase R by capripoxviruses and vaccinia virus.

Ann N Y Acad Sci 2019 Jan 15. Epub 2019 Jan 15.

School of Medicine, Department of Medial Microbiology and Immunology, University of California Davis, Davis, California.

Double-stranded RNA-activated protein kinase R (PKR) is an important and rapidly evolving antiviral kinase. Most poxviruses contain two distinct PKR inhibitors, called E3 and K3 in vaccinia virus (VACV), the prototypic orthopoxvirus. E3 prevents PKR homodimerization by binding double-stranded RNA, while K3 acts as a pseudosubstrate inhibitor by binding directly to activated PKR and thereby inhibiting interaction with its substrate eIF2α. Read More

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http://doi.wiley.com/10.1111/nyas.14000
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http://dx.doi.org/10.1111/nyas.14000DOI Listing
January 2019
8 Reads

Are low-carbohydrate diets safe in diabetic and nondiabetic chronic kidney disease?

Ann N Y Acad Sci 2019 Jan 15. Epub 2019 Jan 15.

Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.

Diabetes mellitus and obesity both contribute to chronic kidney disease (CKD) and diabetic kidney disease (DKD), and they can accelerate the loss of kidney function. Dietary intake can potentially have wide-reaching effects on the risk of CKD/DKD and their progression by reducing weight and blood pressure, improving glycemic control, reducing hyperfiltration, and modulating inflammation. Low-carbohydrate (LC) diets can reduce weight and improve glycemic control, but the relatively higher protein content also raises concern in CKD/DKD. Read More

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http://dx.doi.org/10.1111/nyas.13997DOI Listing
January 2019
1 Read

Retention of osteocytic micromorphology by sclerostin antibody in a concurrent ovariectomy and functional disuse model.

Ann N Y Acad Sci 2019 Jan 15. Epub 2019 Jan 15.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York.

Prolonged mechanical unloading in bedridden patients and concurrent hormonal dysregulation represents the cause of one of the severest forms of osteoporosis, a condition for which there are very few efficacious interventions available to date. Sclerostin, a Wnt antagonist, acts as a negative regulator of bone formation. Sclerostin antibody (Scl-Ab)-mediated blockade of sclerostin can dramatically enhance bone formation and reduce bone resorption. Read More

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http://dx.doi.org/10.1111/nyas.13991DOI Listing
January 2019
1 Read

The neurobiology of addiction.

Ann N Y Acad Sci 2019 Jan 15. Epub 2019 Jan 15.

Substance and alcohol use disorders impose large health and economic burdens on individuals, families, communities, and society. Neither prevention nor treatment efforts are effective in all individuals. Results are often modest. Read More

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http://dx.doi.org/10.1111/nyas.13989DOI Listing
January 2019
7 Reads

Emerging insights from the genetics of cerebral small-vessel disease.

Ann N Y Acad Sci 2019 Jan 8. Epub 2019 Jan 8.

Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Cerebral small-vessel disease (cSVD) is a common cause of stroke, functional decline, vascular cognitive impairment, and dementia. Pathological processes in the brain's microcirculation are tightly interwoven with pathology in the brain parenchyma, and this interaction has been conceptualized as the neurovascular unit (NVU). Despite intensive research efforts to decipher the NVU's structure and function to date, molecular mechanisms underlying cSVD remain poorly understood, which hampers the development of cSVD-specific therapies. Read More

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http://dx.doi.org/10.1111/nyas.13998DOI Listing
January 2019
2 Reads

Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies.

Ann N Y Acad Sci 2018 Sep 14. Epub 2018 Sep 14.

Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, New York.

Despite considerable efforts to develop cellular, molecular, and structural repair strategies and restore intervertebral disk function after injury, the basic biology underlying intervertebral disk healing remains poorly understood. Remarkably, little is known about the origins of cell populations residing within the annulus fibrosus, or their phenotypes, heterogeneity, and roles during healing. This review focuses on recent literature highlighting the intrinsic and extrinsic cell types of the annulus fibrosus in the context of the injury and healing environment. Read More

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http://dx.doi.org/10.1111/nyas.13964DOI Listing
September 2018
1 Read

Recombinant growth differentiation factor 11 impairs fracture healing through inhibiting chondrocyte differentiation.

Ann N Y Acad Sci 2018 Dec 21. Epub 2018 Dec 21.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Growth differentiation factor 11 (GDF11), a secreted member of the transforming growth factor-β (TGF-β) superfamily, has been reported to have the capacity to reverse age-related pathologic changes and regulate organ regeneration after injury; however, the role of GDF11 in fracture healing and bone repair is still unclear. Here, we established a fracture model in 12-week-old male mice to observe two healing states: the cartilaginous callus and bony callus formation phases. Our results showed that recombinant GDF11 (rGDF11) injection inhibits cartilaginous callus maturation and hard callus formation, thereby impairing fracture healing in vivo. Read More

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http://dx.doi.org/10.1111/nyas.13994DOI Listing
December 2018
1 Read
4.313 Impact Factor

The effect of mindfulness meditation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.

Ann N Y Acad Sci 2018 Dec 21. Epub 2018 Dec 21.

National Institute of Nursing Research, National Institutes of Health, Bethesda, Maryland.

There is a growing interest in the effectiveness of mindfulness meditation for sleep disturbed populations. Our study sought to evaluate the effect of mindfulness meditation interventions on sleep quality. To assess for relative efficacy, comparator groups were restricted to specific active controls (such as evidenced-based sleep treatments) and nonspecific active controls (such as time/attention-matched interventions to control for placebo effects), which were analyzed separately. Read More

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http://doi.wiley.com/10.1111/nyas.13996
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http://dx.doi.org/10.1111/nyas.13996DOI Listing
December 2018
6 Reads

Excess micronutrient intake: defining toxic effects and upper limits in vulnerable populations.

Ann N Y Acad Sci 2018 Dec 19. Epub 2018 Dec 19.

The Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.

Excessive micronutrient intake causes a variety of adverse health effects, depending on dose and duration. The risk of excess intake carries significant implications for micronutrient delivery interventions, particularly when such programs are overlapping. To minimize risk and provide public health guidance, several countries and the Food and Agriculture Organization of the United Nations/World Health Organization have set upper intake levels (ULs) for various life-stage populations using the risk assessment framework. Read More

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http://dx.doi.org/10.1111/nyas.13993DOI Listing
December 2018
1 Read

Early career biomedical grantsmanship self-efficacy: validation of an abbreviated self-assessment tool.

Ann N Y Acad Sci 2018 Dec 5. Epub 2018 Dec 5.

Department of Family and Preventative Medicine, University of Utah, Salt Lake City, Utah.

A hallmark of success for early career biomedical researchers is the acquisition of research funding. There are marked disparities among principal investigators who submit grants and the likelihood of receiving national funding. The National Research Mentoring Network was funded by the National Institutes of Health to diversify the biomedical research workforce and included grantsmanship training for early career researchers. Read More

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http://doi.wiley.com/10.1111/nyas.13995
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http://dx.doi.org/10.1111/nyas.13995DOI Listing
December 2018
2 Reads

Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury.

Ann N Y Acad Sci 2019 Feb 29;1437(1):43-56. Epub 2018 Nov 29.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Sepsis occurs when a systemic infection induces an uncontrolled inflammatory response that results in generalized organ dysfunction. The exacerbated peripheral inflammation can induce, in turn, neuroinflammation which may result in severe impairment of the central nervous system (CNS). Indeed, the ensuing blood-brain barrier disruption associated with sepsis promotes glial activation and starts a storm of proinflammatory cytokines in the CNS that leads to brain dysfunction in sepsis survivors. Read More

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http://doi.wiley.com/10.1111/nyas.13985
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http://dx.doi.org/10.1111/nyas.13985DOI Listing
February 2019
5 Reads

Risks of excess iodine intake in Ghana: current situation, challenges, and lessons for the future.

Ann N Y Acad Sci 2018 Nov 29. Epub 2018 Nov 29.

Department of Population, Family and Reproductive Health, University of Ghana, School of Public Health, Legon, Accra, Ghana.

In Ghana, iodine deficiency was first reported in 1994 among 33% of the population. A nationwide Universal Salt Iodization (USI) program plus other complementary interventions were subsequently implemented as a response. Our paper reviews the current risks of excess iodine status in Ghana and identifies policy and research gaps. Read More

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http://dx.doi.org/10.1111/nyas.13988DOI Listing
November 2018
10 Reads
4.313 Impact Factor

Between progress and obstacles in urban climate interdisciplinary studies and knowledge transfer to society.

Ann N Y Acad Sci 2019 Jan 29;1436(1):5-18. Epub 2018 Nov 29.

National Center of Meteorological Research, Météo-France/CNRS, Toulouse, France.

Cities modify their local climate, and at the same time they suffer from the local impacts of climate change. Our paper discusses the progress and obstacles in three active research topics that contribute to increasing the capability within the urban climate research community for transferring local climate knowledge to society. The first is linked to the production of urban surface descriptions useful for urban climate studies. Read More

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http://dx.doi.org/10.1111/nyas.13986DOI Listing
January 2019
15 Reads

Supplementation of micronutrients in children and food fortification initiatives in Sri Lanka: benefits versus risks.

Ann N Y Acad Sci 2018 Nov 28. Epub 2018 Nov 28.

Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

In recent decades, Sri Lanka has made substantial progress in reducing the burden of micronutrient deficiencies in children by the provision of vitamin A megadose and micronutrient supplementation programs for children of 6-23 months, along with universal iodization of salt. Consumption of voluntarily fortified foods by children was also considerably increased. The objective of our study here was to review such interventions, which are beneficial in childhood, and to assess the risk of toxicity due to excessive intakes of iron, vitamin A, and iodine. Read More

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http://doi.wiley.com/10.1111/nyas.13987
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http://dx.doi.org/10.1111/nyas.13987DOI Listing
November 2018
10 Reads

Interactions between recreational cannabis use and cognitive function: lessons from functional magnetic resonance imaging.

Ann N Y Acad Sci 2018 Nov 13. Epub 2018 Nov 13.

Cognitive and Clinical Neuroimaging Core, McLean Hospital, Belmont, Massachusetts.

Cannabis use is becoming increasingly popular as a growing number of states pass legislation to legalize cannabis and cannabis-derived products for recreational and/or medical purposes. Given the widespread use of cannabis, it is critical to understand the neural consequences related to cannabis use. In this review, we focus on evidence from functional magnetic resonance imaging studies that document acute and residual alterations in brain function during tasks spanning a variety of cognitive domains: executive function, attention and working memory, memory, motor skills, error monitoring, and reward and affective processing. Read More

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http://doi.wiley.com/10.1111/nyas.13990
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http://dx.doi.org/10.1111/nyas.13990DOI Listing
November 2018
16 Reads

Species-specific inhibition of capripoxvirus replication by host antiviral protein kinase R.

Ann N Y Acad Sci 2018 Nov 1. Epub 2018 Nov 1.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of the Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

The role of interferon (IFN)-induced protein kinase R (PKR) in capripoxvirus (CaPV)-infected cells remains unknown. In this study, we show that CaPV infection triggered PKR and eukaryotic translation initiation factor 2 alpha (eIF2α) protein phosphorylation in a dose-dependent manner, and that this leads to decreased CaPV replication. Overexpression of PKR compromised viral gene expression and inhibited sheeppox virus (SPPV) replication. Read More

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http://dx.doi.org/10.1111/nyas.13976DOI Listing
November 2018
2 Reads

Effects of phytochemicals on thyroid function and their possible role in thyroid disease.

Ann N Y Acad Sci 2018 Nov 1. Epub 2018 Nov 1.

Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez, Biochimica, Università Politecnica delle Marche, Ancona, Italy.

About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of thyroid cancers. Read More

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http://doi.wiley.com/10.1111/nyas.13980
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http://dx.doi.org/10.1111/nyas.13980DOI Listing
November 2018
8 Reads

Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.

Ann N Y Acad Sci 2018 Nov 1. Epub 2018 Nov 1.

Department of Physiology, School of Medicine, Shinshu University, Nagano, Japan.

LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1; also known as OLR1) is the dominant receptor that recognizes and internalizes oxidized low-density lipoproteins (ox-LDLs) in endothelial cells. Several genetic variants of LOX-1 are associated with the risk and severity of coronary artery disease. The LOX-1-ox-LDL interaction induces endothelial dysfunction, leukocyte adhesion, macrophage-derived foam cell formation, smooth muscle cell proliferation and migration, and platelet activation. Read More

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http://doi.wiley.com/10.1111/nyas.13984
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http://dx.doi.org/10.1111/nyas.13984DOI Listing
November 2018
11 Reads

Provision of micronutrients in coexisting public health programs and risk of excessive intake: regulatory considerations.

Ann N Y Acad Sci 2018 Oct 22. Epub 2018 Oct 22.

Evidence and Programme Guidance, Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland.

Countries around the world have been implementing public health interventions to provide vitamins and minerals. There is a concern that the cumulative micronutrient contribution of coexisting programs, when targeting the same population, may exceed their safe levels of intake, thus potentially challenging the primum non nocere principle. We assessed the regulatory framework of such interventions and determined qualitatively whether there were provisions in the regulations that called for coordination among programs to ensure their innocuousness. Read More

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http://doi.wiley.com/10.1111/nyas.13972
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http://dx.doi.org/10.1111/nyas.13972DOI Listing
October 2018
12 Reads

What is animal happiness?

Ann N Y Acad Sci 2018 Oct 22. Epub 2018 Oct 22.

Department of Animal Science - Behaviour and Stress Biology Group, Aarhus University, Tjele, Denmark.

Today, we see a growing concern for the quality of life of nonhuman animals and an accompanying call for viable means of assessing how well animals thrive. Past research focused on minimizing negatives such as stress, while more recent endeavors strive to promote positives such as happiness. But what is animal happiness? Although often mentioned, the term lacks a clear definition. Read More

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http://dx.doi.org/10.1111/nyas.13983DOI Listing
October 2018
1 Read

The Will to Meaning: Seeking the Why of Our Existence.

Authors:
Steve Paulson

Ann N Y Acad Sci 2018 Nov 12;1432(1):6-9. Epub 2018 Oct 12.

Wisconsin Public Radio, Madison, Wisconsin.

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http://doi.wiley.com/10.1111/nyas.13981
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http://dx.doi.org/10.1111/nyas.13981DOI Listing
November 2018
4 Reads

Models, movements, and minds: bridging the gap between decision making and action.

Ann N Y Acad Sci 2018 Oct 12. Epub 2018 Oct 12.

Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.

Decision making is a fundamental cognitive function, which not only determines our day-to-day choices but also shapes the trajectories of our movements, our lives, and our societies. While immense progress has been made in recent years on our understanding of the mechanisms underlying decision making, research on this topic is still largely split into two halves. Good-based models largely state that decisions are made between representations of abstract value associated with available options; while action-based models largely state that decisions are made at the level of action representations. Read More

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http://dx.doi.org/10.1111/nyas.13973DOI Listing
October 2018
2 Reads

The Will to Meaning: Seeking the Why of Our Existence.

Authors:
Richard Rass

Ann N Y Acad Sci 2018 Nov 12;1432(1):3-5. Epub 2018 Oct 12.

Program Director, the Nour Foundation, New York, New York.

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http://doi.wiley.com/10.1111/nyas.13982
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http://dx.doi.org/10.1111/nyas.13982DOI Listing
November 2018
4 Reads

Can we distinguish three maintenance processes in working memory?

Ann N Y Acad Sci 2018 Jul 26;1424(1):45-51. Epub 2018 Jul 26.

We describe three mechanisms—consolidation, refreshing, and removal—as processes that may serve to strengthen new memories. We detail their explicit and implied differences and similarities, and highlight points upon which theorists disagree about their supposed characteristics. We consider the challenges remaining in refining definitions of these processes and with situating them within working memory theories, and consider how these process definitions and theories should restrict each other. Read More

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http://dx.doi.org/10.1111/nyas.13925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183061PMC
July 2018
1 Read

From Amazonia to southern Africa: atmospheric moisture transport through low-level jets and atmospheric rivers.

Ann N Y Acad Sci 2019 Jan 18;1436(1):217-230. Epub 2018 Sep 18.

Instituto Dom Luiz (IDL), Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.

A Lagrangian analysis is applied to identify the main moisture source areas associated with atmospheric rivers (ARs) making landfall along the west coast of South Africa during the extended austral winter months from 1980 to 2014. The results show that areas that provide the anomalous uptake of moisture can be categorized into four regions: (1) the South Atlantic Ocean between 10°S and 30°S, (2) a clear local maximum in the eastern South Atlantic, (3) a continental source of anomalous uptake to the north of the Western Cape, and (4) over South America at a distance of more than 7000 km from the target region. It emerges that the South American moisture source can be linked to a particular phase of the South American low-level jet, known as a no Chaco jet event (NCJE), which transports moisture to the western and central South Atlantic basin. Read More

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http://doi.wiley.com/10.1111/nyas.13960
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http://dx.doi.org/10.1111/nyas.13960DOI Listing
January 2019
14 Reads

Historical weather data for climate risk assessment.

Ann N Y Acad Sci 2019 Jan 5;1436(1):121-137. Epub 2018 Oct 5.

Research Center for Environmental Changes, Academia Sinica, Taipei, Taiwan.

Weather- and climate-related hazards are responsible for monetary losses, material damages, and societal consequences. Quantifying related risks is, therefore, an important societal task, particularly in view of future climate change. For this task, climate risk assessment increasingly uses model chains, which mainly build on data from the last few decades. Read More

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http://dx.doi.org/10.1111/nyas.13966DOI Listing
January 2019
2 Reads

Risk of excessive intake of vitamins and minerals delivered through public health interventions: objectives, results, conclusions of the meeting, and the way forward.

Ann N Y Acad Sci 2018 Oct 5. Epub 2018 Oct 5.

Nutrition and Social Determinants, the Pan American Health Organization, Washington, DC.

The excessive consumption of certain vitamins and minerals could have deleterious consequences on health and development of individuals and populations. Simultaneous micronutrient-delivery interventions could be challenging in terms of safety as the target populations may overlap, posing a risk of excessive intake of certain micronutrients. The Evidence and Programme Guidance Unit of the Department of Nutrition for Health and Development of the World Health Organization convened a technical consultation on the risk of excessive intake of vitamins and minerals delivered through public health interventions in October 2017. Read More

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http://doi.wiley.com/10.1111/nyas.13975
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http://dx.doi.org/10.1111/nyas.13975DOI Listing
October 2018
19 Reads

The neurobiology of impulsivity and substance use disorders: implications for treatment.

Ann N Y Acad Sci 2018 Oct 5. Epub 2018 Oct 5.

Addictions Division, Centre for Addiction and Mental Health (CAMH), University of Toronto, Toronto, Ontario, Canada.

Impulsivity is strongly associated with substance use disorders (SUDs). Our review discusses impulsivity as an underlying vulnerability marker for SUDs, and treatment of co-occurring impulsivity in SUDs. Three factors should be considered for the complex relationship between impulsivity and a SUD: (1) the trait effect of impulsivity, centering on decreased cognitive and response inhibition, (2) the state effect resulting from either acute or chronic substance use on brain structure and function, and (3) the genetic and environmental factors (e. Read More

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http://dx.doi.org/10.1111/nyas.13977DOI Listing
October 2018
1 Read

Aging, the menopausal transition, and hormone replenishment therapy: retrieval of confidence and compliance.

Ann N Y Acad Sci 2018 Oct 4. Epub 2018 Oct 4.

Division of Endocrinology, Diabetes and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

The negative health consequences of age and the postmenopausal hypoestrogenic state and their clinical management are described in this paper. While some dysfunctional elements are irreversibly entrained, others can be modified by an updated menopausal hormone therapy (MHT) strategy reflecting revision and reassessment of the initial Women's Health Initiative (WHI) reports. However, until that positive outcome is realized, menopausal women and their healthcare providers must re-establish willingness to utilize these effective strategies. Read More

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http://dx.doi.org/10.1111/nyas.13952DOI Listing
October 2018
3 Reads

The role of the dorsal striatum in choice impulsivity.

Ann N Y Acad Sci 2018 Sep 17. Epub 2018 Sep 17.

Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of Korea.

It has long been recognized that the dorsal striatum is an essential brain region for control of action selection based on action-outcome contingency learning, particularly when the available actions are bound to rewarding outcomes. In principle, intertemporal choice in the delay-discounting task-a validated measure of choice impulsivity-involves reward-associated actions that require the recruitment of the dorsal striatum. Here, we conjecture about ways the dorsal striatum is involved in choice impulsivity. Read More

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http://doi.wiley.com/10.1111/nyas.13961
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http://dx.doi.org/10.1111/nyas.13961DOI Listing
September 2018
17 Reads

Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: case studies.

Ann N Y Acad Sci 2018 Sep 28. Epub 2018 Sep 28.

Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.

Vitamin A (VA) deficiency is a serious public health problem, especially in preschool children who are at risk of increased mortality. In order to address this problem, the World Health Organization recommends periodic high-dose supplementation to children 6-59 months of age in areas of highest risk. Originally, supplementation was meant as a short-term solution until more sustainable interventions could be adopted. Read More

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http://doi.wiley.com/10.1111/nyas.13965
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http://dx.doi.org/10.1111/nyas.13965DOI Listing
September 2018
11 Reads

Adaptation to environmental stress at different timescales.

Ann N Y Acad Sci 2018 Sep 27. Epub 2018 Sep 27.

Department of Biology and Environmental Sciences, University of Jyväskylä, Jyväskylä, Finland.

Environments are changing rapidly, and to cope with these changes, organisms have to adapt. Adaptation can take many shapes and occur at different speeds, depending on the type of response, the trait, the population, and the environmental conditions. The biodiversity crisis that we are currently facing illustrates that numerous species and populations are not capable of adapting with sufficient speed to ongoing environmental changes. Read More

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http://doi.wiley.com/10.1111/nyas.13974
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http://dx.doi.org/10.1111/nyas.13974DOI Listing
September 2018
21 Reads

The gut-brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation.

Ann N Y Acad Sci 2018 Sep;1428(1):129-150

Frontiers Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, Sendai, Japan.

Over the past few years, scientific interest in the gut-brain axis (i.e., the bidirectional communication system between the gastrointestinal tract and the brain) has exploded, mostly due to the identification of the gut microbiota as a novel key player in this communication. Read More

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http://dx.doi.org/10.1111/nyas.13969DOI Listing
September 2018
2 Reads

Global folate status in women of reproductive age: a systematic review with emphasis on methodological issues.

Ann N Y Acad Sci 2018 Nov 21;1431(1):35-57. Epub 2018 Sep 21.

Foods and Nutrition Department, University of Georgia, Athens, Georgia.

Inadequate folate status in women of reproductive age (WRA) can lead to adverse health consequences of public health significance, such as megaloblastic anemia (folate deficiency) and an increased risk of neural tube defect (NTD)-affected pregnancies (folate insufficiency). Our review aims to evaluate current data on folate status of WRA. We queried eight databases and the World Health Organization Micronutrients Database, identifying 45 relevant surveys conducted between 2000 and 2014 in 39 countries. Read More

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http://dx.doi.org/10.1111/nyas.13963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282622PMC
November 2018
4 Reads
4.313 Impact Factor

Novel therapies and preventative strategies for primary and recurrent Clostridium difficile infections.

Ann N Y Acad Sci 2019 Jan 21;1435(1):110-138. Epub 2018 Sep 21.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan.

Clostridium difficile is the leading infectious cause of antibiotic-associated diarrhea and colitis. C. difficile infection (CDI) places a heavy burden on the healthcare system, with nearly half a million infections yearly and an approximate 20% recurrence risk after successful initial therapy. Read More

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http://dx.doi.org/10.1111/nyas.13958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312459PMC
January 2019
1 Read

Pathways to resilience: adapting to sea level rise in Los Angeles.

Ann N Y Acad Sci 2018 Sep;1427(1):1-90

University of Southern California Sea Grant, Los Angeles, California.

Los Angeles (LA) County's coastal areas are highly valued for their natural benefits and their economic contributions to the region. While LA County already has a high level of exposure to flooding (e.g. Read More

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http://doi.wiley.com/10.1111/nyas.13917
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http://dx.doi.org/10.1111/nyas.13917DOI Listing
September 2018
3 Reads

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries.

Ann N Y Acad Sci 2018 Oct 18;1430(1):44-79. Epub 2018 Sep 18.

University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods rich in vitamin D and inadequate exposure to natural ultraviolet B (UVB) radiation from sunlight, an important proportion of the global population is at risk of vitamin D deficiency. There is general agreement that the minimum serum/plasma 25-hydroxyvitamin D concentration (25(OH)D) that protects against vitamin D deficiency-related bone disease is approximately 30 nmol/L; therefore, this threshold is suitable to define vitamin D deficiency in population surveys. Read More

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http://dx.doi.org/10.1111/nyas.13968DOI Listing
October 2018
1 Read
4.313 Impact Factor

Training proprioception with sound: effects of real-time auditory feedback on intermodal learning.

Ann N Y Acad Sci 2018 Sep 17. Epub 2018 Sep 17.

The Institute of Sports Science, Leibniz University Hannover, Hannover, Germany.

Our study analyzed the effects of real-time auditory feedback on intermodal learning during a bilateral knee repositioning task. Thirty healthy participants were randomly allocated to control and experimental groups. Participants performed an active knee joint repositioning task for the four target angles (20°, 40°, 60°, and 80°) bilaterally, with or without additional real-time auditory feedback. Read More

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http://dx.doi.org/10.1111/nyas.13967DOI Listing
September 2018
1 Read

Generic chemoprevention of hepatocellular carcinoma.

Ann N Y Acad Sci 2018 Sep 17. Epub 2018 Sep 17.

Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Chronic fibrotic liver disease caused by viral or metabolic etiologies is a high-risk condition for developing hepatocellular carcinoma (HCC). Even after curative treatment of early-stage HCC tumor, the carcinogenic microenvironment persists in the remnant diseased liver and supports the development of de novo HCC tumors (de novo HCC recurrence). Therefore, prevention of HCC development in patients at risk of not only first-primary but also second-primary HCC tumors is theoretically the most impactful strategy to improve patient prognosis. Read More

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http://dx.doi.org/10.1111/nyas.13971DOI Listing
September 2018
2 Reads

SND1 expression in breast cancer tumors is associated with poor prognosis.

Ann N Y Acad Sci 2018 Dec 14;1433(1):53-60. Epub 2018 Sep 14.

Department of Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Staphylococcal nuclease domain-containing 1 (SND1) expression is crucial for breast cancer metastasis; however, the clinical implications of SND1 expression in breast cancer remain unclear. This study investigated the relationship of SND1 protein expression both with metastasis and the prognoses of 144 breast cancer patients over a 10-year follow-up. Chi-square tests revealed that the percentages of positive SND1 expression in breast cancer tumors were significantly associated with larger tumor size (>2 cm, P = 0. Read More

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http://dx.doi.org/10.1111/nyas.13970DOI Listing
December 2018
2 Reads

The evolution of surgical approach for esophageal cancer.

Ann N Y Acad Sci 2018 Dec 7;1434(1):149-155. Epub 2018 Sep 7.

Department of Surgery, the Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Esophageal surgery for esophageal cancer has been performed for over a century now. Minimally invasive esophagectomy (MIE) was first described in 1992, and it is now a standard approach in many countries. However, MIE is technically difficult and requires a long learning curve. Read More

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http://dx.doi.org/10.1111/nyas.13957DOI Listing
December 2018
1 Read

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs.

Ann N Y Acad Sci 2018 Oct 27;1430(1):3-43. Epub 2018 Aug 27.

Jean Mayer USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts.

Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Read More

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http://dx.doi.org/10.1111/nyas.13919DOI Listing
October 2018
5 Reads

Cancer of the gastroesophageal junction: a diagnosis, classification, and management review.

Ann N Y Acad Sci 2018 Dec 23;1434(1):132-138. Epub 2018 Aug 23.

Department of Surgery, Royal Marsden Hospital, London, UK.

Management of gastroesophageal junction (GEJ) adenocarcinoma is a controversial topic. The rising incidence of this cancer requires a clear consensus to ensure proper management. Application of oncological principles for tumors of the esophagus or stomach is not possible because of comparative differences in the biology of GEJ adenocarcinoma, leading to different therapeutic options. Read More

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http://dx.doi.org/10.1111/nyas.13954DOI Listing
December 2018
2 Reads

Changing resource landscapes and spillover of henipaviruses.

Ann N Y Acad Sci 2018 Oct 23;1429(1):78-99. Epub 2018 Aug 23.

Department of Ecology, Montana State University, Bozeman, Montana.

Old World fruit bats (Chiroptera: Pteropodidae) provide critical pollination and seed dispersal services to forest ecosystems across Africa, Asia, and Australia. In each of these regions, pteropodids have been identified as natural reservoir hosts for henipaviruses. The genus Henipavirus includes Hendra virus and Nipah virus, which regularly spill over from bats to domestic animals and humans in Australia and Asia, and a suite of largely uncharacterized African henipaviruses. Read More

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http://dx.doi.org/10.1111/nyas.13910DOI Listing
October 2018
5 Reads

Early esophageal cancer: the significance of surgery, endoscopy, and chemoradiation.

Ann N Y Acad Sci 2018 Dec 23;1434(1):115-123. Epub 2018 Aug 23.

Department of General and Visceral Surgery, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany.

Early carcinomas of the esophagus are histologically classified as adenocarcinoma or squamous cell carcinoma and microscopically subdivided into mucosal and submucosal carcinomas depending on infiltration depth. The prevalence of lymph node metastasis in mucosal carcinoma remains low. However, lymph node metastases arise frequently from tumors with submucosal infiltration, with increasing prevalence in the deeper submucosal sublayers. Read More

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http://dx.doi.org/10.1111/nyas.13955DOI Listing
December 2018
9 Reads