2,683 results match your criteria Annals of the American Thoracic Society[Journal]


Ultrasound Evaluation of Diaphragm Force Reserve in Patients with Chronic Obstructive Pulmonary Disease.

Ann Am Thorac Soc 2020 Jul 2. Epub 2020 Jul 2.

St Michael's Hospital in Toronto, Li Ka Shing Knowledge Institute, Keenan Research Centre, Toronto, Ontario, Canada.

Rationale: Diaphragm function is a key determinant of dyspnea in COPD; however, it is rarely assessed in clinical practice. Lung hyperinflation can also impair diaphragm function. Ultrasound can assess the activity, function and the force reserve of the diaphragm. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202002-129OCDOI Listing

Diagnostic Features in Combined Pulmonary Fibrosis and Emphysema (CPFE): A Systematic Review.

Ann Am Thorac Soc 2020 Jul 1. Epub 2020 Jul 1.

The University of British Columbia Faculty of Medicine, 12358, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1513/AnnalsATS.202002-122RLDOI Listing

Infectious Disease Transmission Models to Predict, Evaluate, and Improve Understanding of SARS-COV-2 Trajectory and Interventions.

Ann Am Thorac Soc 2020 Jul 1. Epub 2020 Jul 1.

Colorado School of Public Health, 144805, Environmental and Occupational Health, Aurora, Colorado, United States.

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http://dx.doi.org/10.1513/AnnalsATS.202005-501PSDOI Listing

Protective Strategies in a Simulated Model When Performing Percutaneous Tracheostomies in the COVID-19 Era.

Ann Am Thorac Soc 2020 Jul 1. Epub 2020 Jul 1.

Beth Israel Deaconess Medical Center, Interventional Pulmonology, Boston, Massachusetts, United States;

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http://dx.doi.org/10.1513/AnnalsATS.202004-372RLDOI Listing

Progressive Fibrosing Interstitial Lung Disease: A Proposed Integrated Algorithm for Management.

Ann Am Thorac Soc 2020 Jul 1. Epub 2020 Jul 1.

Universita Cattolica del Sacro Cuore Sede di Roma, 96983, Pulmonary Medicine, Roma, Lazio, Italy.

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http://dx.doi.org/10.1513/AnnalsATS.202003-214PSDOI Listing

Take Me Home to the Place I Belong: Discharging the Tracheostomy-Dependent Child.

Ann Am Thorac Soc 2020 Jul;17(7):809-810

Department of Pediatrics-Pulmonary Medicine, University of Colorado School of Medicine, Aurora, Colorado.

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http://dx.doi.org/10.1513/AnnalsATS.202004-349EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328180PMC

Navigating Discharges from Intensive Care Unit to Ward.

Ann Am Thorac Soc 2020 Jul;17(7):807-808

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.

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http://dx.doi.org/10.1513/AnnalsATS.202003-227EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328182PMC

Right Ventricular Air Embolus. A Physiologic Approach to Management.

Ann Am Thorac Soc 2020 Jul;17(7):892-894

Department of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1513/AnnalsATS.201911-824CCDOI Listing

Recognizing a Patient is Acutely Dying.

Ann Am Thorac Soc 2020 Jun 30. Epub 2020 Jun 30.

University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan, United States;

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http://dx.doi.org/10.1513/AnnalsATS.202002-115IPDOI Listing

Comparison of Multiple Breath Washout and Spirometry in Children with Primary Ciliary Dyskinesia and Cystic Fibrosis and Healthy Controls.

Ann Am Thorac Soc 2020 Jun 30. Epub 2020 Jun 30.

Washington University in Saint Louis School of Medicine, 12275, Pediatrics, Saint Louis, Missouri, United States.

Rationale: In cystic fibrosis (CF), the lung clearance index (LCI) derived from multiple breath washout (MBW) is more sensitive in detecting early lung disease than FEV1; MBW has been less thoroughly evaluated in young patients with PCD.

Objectives: To evaluate (1) sensitivity of MBW and spirometry for detection of mild lung disease in young children with PCD and CF compared to healthy controls (HC), and (2) compare patterns of airway obstruction between disease populations.

Methods: Multicenter, single visit, observational study in children with PCD and CF with an FEV1 >60% predicted and HC, ages 3-12 years. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201905-375OCDOI Listing

Reexamining Rates of Decline in Lung Cancer Risk after Smoking Cessation: A meta-analysis.

Ann Am Thorac Soc 2020 Jun 30. Epub 2020 Jun 30.

University of Washington, 7284, Seattle, Washington, United States.

Rationale: Prior studies have questioned whether prevailing eligibility criteria for lung cancer screening are sufficiently inclusive of former smokers who remain at elevated risk of disease outside current screening windows.

Objective: Characterize the percent of the reducible relative risk remaining (RRR) for lung cancer as a function of years since quitting.

Methods: MEDLINE and PubMed were searched from January 2011 to May 2018; key search terms included smoking and cancer. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201909-659OCDOI Listing

Urban-Rural Disparities in Pulmonary Hypertension Mortality.

Ann Am Thorac Soc 2020 Jun 25. Epub 2020 Jun 25.

Harvard Medical School & Harvard Pilgrim Health Care Institute, Population Medicine, Boston, Massachusetts, United States;

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http://dx.doi.org/10.1513/AnnalsATS.202003-234RLDOI Listing

Increased Work of Breathing Due to Tracheomalacia in Neonates.

Ann Am Thorac Soc 2020 Jun 24. Epub 2020 Jun 24.

Cincinnati Children's Hospital Medical Center, 2518, Center for Pulmonary Imaging Research, Cincinnati, Ohio, United States.

Rationale: Dynamic collapse of the tracheal lumen (tracheomalacia) occurs frequently in premature neonates, particularly those with common comorbidities such as bronchopulmonary dysplasia. The tracheal collapse increases the effort necessary to breathe (work of breathing, WOB). However, quantifying the increased WOB related to tracheomalacia has previously not been possible. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202002-162OCDOI Listing

Antifibrotic Drug Use in Patients with IPF: Data from the IPF-PRO Registry.

Ann Am Thorac Soc 2020 Jun 23. Epub 2020 Jun 23.

Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, United States.

Rationale: Two antifibrotic medications, nintedanib and pirfenidone, have been approved for the treatment of idiopathic pulmonary fibrosis (IPF) in the US. Few data have been published on the use of these medications in clinical practice.

Objective: To investigate patterns of use of antifibrotic medications in the US. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201912-880OCDOI Listing

Bronchoscopic Lung Volume Reduction with Valves and Coils: A Network Meta-analysis.

Ann Am Thorac Soc 2020 Jun 23. Epub 2020 Jun 23.

University of Colorado Denver School of Medicine, 12225, Aurora, Colorado, United States.

Background: Coils and endobronchial valves are the most widely used bronchoscopic lung volume reduction devices in patients with advanced emphysema. However, the choice of each specific device depends on emphysema characteristics (homogeneous vs heterogeneous) and presence of lobar collateral ventilation (CV). These devices have not been compared in a head-to-head study design. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202002-151OCDOI Listing

COVID-19, Climate Change, and the American Thoracic Society: A Shared Responsibility.

Ann Am Thorac Soc 2020 Jun 23. Epub 2020 Jun 23.

Children's Hospital, Pulmonary Medicine, Cincinnati, Ohio, United States.

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http://dx.doi.org/10.1513/AnnalsATS.202002-180VPDOI Listing

Thoracic Visceral Adipose Tissue Area and Pulmonary Hypertension in Lung Transplant Candidates: The Lung Transplant Body Composition Study.

Ann Am Thorac Soc 2020 Jun 12. Epub 2020 Jun 12.

University of Pennsylvania Perelman School of Medicine, 14640, Medicine , Philadelphia, Pennsylvania, United States.

Rationale: Obesity is associated with an increased risk of pulmonary hypertension (PH), however regional adipose tissue deposition is heterogeneous with distinct cardiovascular phenotypes.

Objective: To determine the association of body mass index (BMI), thoracic visceral and subcutaneous adipose tissue areas (VAT and SAT, respectively) with PH in patients with advanced lung disease referred for lung transplantation.

Methods: We studied patients undergoing evaluation for lung transplantation at 3 centers from the Lung Transplant Body Composition Study. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202003-247OCDOI Listing

Dual LABA/LAMA Therapy versus LABA or LAMA Monotherapy for COPD: A Systematic Review and Meta-analysis in Support of the American Thoracic Society Clinical Practice Guideline.

Ann Am Thorac Soc 2020 Jun 12. Epub 2020 Jun 12.

McMaster University, 3710, Hamilton, Ontario, Canada.

Rationale: There is uncertainty on the optimal first-line therapy for symptomatic COPD. Long-acting beta-2-receptor agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) have long been mainstays of treatment, though it is still not clear if dual therapy with LABA/LAMA is superior to monotherapy for symptomatic COPD.

Objectives: To clarify the evidence landscape, we conducted a systematic review to answer the following question: In patients with COPD who complain of dyspnea and/or exercise intolerance, is LABA/LAMA combination therapy more effective and equally safe compared to LABA or LAMA monotherapy?

Methods: A search of MEDLINE, EMBASE, and the Cochrane Library databases was conducted by a medical librarian for randomized controlled trials (RCTs) enrolling patients with COPD who complain of dyspnea and/or exercise intolerance, that compare LABA/LAMA combination therapy to LABA or LAMA monotherapy. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201912-915OCDOI Listing

Bundle of Coated Devices to Reduce Nosocomial Infections in the Intensive Care Unit: CRITIC Pilot Randomized Controlled Trial.

Ann Am Thorac Soc 2020 Jun 11. Epub 2020 Jun 11.

Instituto Latino-Americano de Sepsis, Sao Paulo, Brazil.

Rationale: Coated devices may reduce biofilm formation and reduce occurrence of device-related infections in critically ill patients. A bundle of coated devices (endotracheal tube - ETT, central venous catheter - CVC, urinary catheter - UC) simultaneously inserted may optimize benefits of coated devices in most severe patients.

Objectives: To assess feasibility of a randomized controlled trial on simultaneous insertion of gold-silver-palladium coated devices versus uncoated devices in severely ill patients required sequential insertion of all three devices (ETT, CVC and UC) for support in intensive care unit (ICU). Read More

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http://dx.doi.org/10.1513/AnnalsATS.202003-206OCDOI Listing

Elucidating Predictors of Obesity Hypoventilation Syndrome in a Large Bariatric Surgery Cohort.

Ann Am Thorac Soc 2020 Jun 11. Epub 2020 Jun 11.

Case Western Reserve University, Sleep Center, Neurologic Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States;

Rationale: Although understanding predictors of obesity hypoventilation syndrome (OHS), a condition associated with increased morbidity and mortality, is of key importance for risk prediction, existing characterization is limited.

Objectives: We hypothesize that OHS patients referred for bariatric surgery have more severe obstructive sleep apnea (OSA) and metabolic derangements compared to their eucapnic counterparts.

Methods: 1718 patients undergoing polysomnography (PSG) with end-tidal CO2 monitoring prior to bariatric surgery at Cleveland Clinic from September 2011 to September 2018 were included. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202002-135OCDOI Listing

Association of a Novel Index of Hospital Capacity Strain with Admission to Intensive Care Units.

Ann Am Thorac Soc 2020 Jun 10. Epub 2020 Jun 10.

Kaiser Permanente, 6152, Division of Research, Oakland, California, United States.

Rationale: Prior approaches to measuring healthcare capacity strain have been constrained by using individual care units, limited metrics of strain, or general, rather than disease-specific, populations.

Objectives: We sought to develop a novel composite strain index and measure its association with ICU admission decisions and hospital outcomes.

Methods: Using more than 9. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202003-228OCDOI Listing

Pulse Oximetry for Monitoring Patients with COVID-19 at Home: Potential Pitfalls and Practical Guidance.

Ann Am Thorac Soc 2020 Jun 10. Epub 2020 Jun 10.

University of Washington, Medicine, Seattle, Washington, United States.

During the ongoing COVID-19 pandemic, reports in social media and the lay press indicate that a subset of patients are presenting with severe hypoxemia in the absence of dyspnea, a problem unofficially referred to as "silent hypoxemia." To decrease the risk of complications in such patients, one proposed solution has been to have those diagnosed with COVID-19 but not sick enough to warrant admission monitor their arterial oxygenation by pulse oximetry at home and present for care when they show evidence of hypoxemia. While the ease of use and low cost of pulse oximetry makes this an attractive option for identifying problems at an early stage, there are important considerations with pulse oximetry about which patients and providers may not be aware that can interfere with successful implementation of such monitoring programs. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202005-418FRDOI Listing

Air Hunger and Psychological Trauma in Ventilated COVID-19 Patients: An Urgent Problem.

Ann Am Thorac Soc 2020 Jun 5. Epub 2020 Jun 5.

Beth Israel Deaconess Medical Center, 1859, Division for Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1513/AnnalsATS.202004-322VPDOI Listing

"We Just Never Have Enough Time": Clinician Views of Lung Cancer Screening Processes and Implementation.

Ann Am Thorac Soc 2020 Jun 4. Epub 2020 Jun 4.

VA Portland Health Care System, Section of Pulmonary and Critical Care Medicine, Portland, Oregon, United States.

Rationale: Despite a known mortality benefit, lung cancer screening (LCS) implementation has been unexpectedly slow. New programs face barriers to implementation, which may include lack of clinician engagement or beliefs that the intervention is not beneficial.

Objective: To evaluate diverse clinician perspectives on their views of LCS and their experience with LCS implementation and processes. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202003-262OCDOI Listing

Patients as Researchers in Adult Critical Care Medicine: Fantasy or Reality?

Ann Am Thorac Soc 2020 Jun 4. Epub 2020 Jun 4.

University of Calgary Cumming School of Medicine, 70401, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1513/AnnalsATS.201911-847IPDOI Listing

Rationale and Design of ORCHID: A Randomized Placebo-Controlled Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19.

Ann Am Thorac Soc 2020 Jun 3. Epub 2020 Jun 3.

Vanderbilt University Medical Center, 12328, Emergency Medicine, Nashville, Tennessee, United States.

The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with COVID-19. This document provides the rationale and background for the trial and highlights key design features. We discuss five novel challenges to the design and conduct of a large, multi-center, randomized trial during a pandemic, including: 1) widespread, off-label use of the study drug before the availability of safety and efficacy data; 2) the need to adapt traditional procedures for documentation of informed consent during an infectious pandemic; 3) developing a flexible and robust Bayesian analysis incorporating significant uncertainty about the disease, outcomes, and treatment; 4) obtaining indistinguishable drug and placebo without delaying enrollment; and 5) rapidly obtaining administrative and regulatory approvals. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202005-478SDDOI Listing

Preparing for COVID-19 Related Drug Shortages.

Ann Am Thorac Soc 2020 Jun 3. Epub 2020 Jun 3.

Johns Hopkins Medicine, 1501, Baltimore, Maryland, United States.

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http://dx.doi.org/10.1513/AnnalsATS.202004-362VPDOI Listing

Repeatability of Pulmonary Pressure Measurements in Patients with Pulmonary Hypertension.

Ann Am Thorac Soc 2020 Jun 2. Epub 2020 Jun 2.

Cleveland Clinic, 2569, Pulmonary, Allergy and Critical Care Medicine, Cleveland, Ohio, United States;

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http://dx.doi.org/10.1513/AnnalsATS.202002-182RLDOI Listing

Acute-Onset Metabolic Acidosis in a Woman with Pneumonia.

Ann Am Thorac Soc 2020 06;17(6):767-769

Division of Pulmonary & Critical Care Medicine, University of Connecticut Health Center, Farmington, Connecticut.

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http://dx.doi.org/10.1513/AnnalsATS.201911-861CCDOI Listing

Better with Time: Reductions in Mortality in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Authors:
Denitza P Blagev

Ann Am Thorac Soc 2020 06;17(6):684-685

Pulmonary and Intensive Medicine Division, Intermountain Medical Center, Murray, Utah; and Pulmonary and Critical Care Medicine Division, University of Utah, Salt Lake City, Utah.

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http://dx.doi.org/10.1513/AnnalsATS.202002-178EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258419PMC

More Than Dollars and Cents: Putting a Price on Indwelling Pleural Catheter Drainage.

Ann Am Thorac Soc 2020 06;17(6):685-687

Oxford Centre for Respiratory Medicine, Oxford University Hospitals, Oxford, United Kingdom.

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http://dx.doi.org/10.1513/AnnalsATS.202003-230EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258413PMC

Prognosis for Mechanically Ventilated Patients: A Moving Target.

Ann Am Thorac Soc 2020 06;17(6):682-683

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; and.

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http://dx.doi.org/10.1513/AnnalsATS.202003-242EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258418PMC

Emphysema in a Middle-aged Former Smoker.

Ann Am Thorac Soc 2020 06;17(6):762-766

Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio; and.

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http://dx.doi.org/10.1513/AnnalsATS.202001-057CCDOI Listing

Summary for Clinicians: 2019 Clinical Practice Guideline Summary for the Treatment of Drug-Resistant Tuberculosis.

Ann Am Thorac Soc 2020 May 28. Epub 2020 May 28.

Mt Auburn Hospital, Pulmonary and Critical Care, Cambridge, Massachusetts, United States.

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http://dx.doi.org/10.1513/AnnalsATS.202004-318CMEDOI Listing

A Randomized Trial of Behavioral Nudges to Improve Enrollment in Critical Care Trials.

Ann Am Thorac Soc 2020 May 22. Epub 2020 May 22.

University of Pennsylvania Perelman School of Medicine, 14640, Medicine, Philadelphia, Pennsylvania, United States.

Rationale: Low and slow patient enrollment remains a barrier to critical care randomized controlled trials (RCTs). Behavioral economic insights suggest that nudges may address some enrollment challenges.

Objectives: To evaluate the efficacy of a novel pre-consent survey consisting of nudges on critical care RCT enrollment. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202003-194OCDOI Listing

Recurrent Pulmonary Fibrosis in a Lung Allograft Secondary to Antisynthetase Syndrome.

Ann Am Thorac Soc 2020 Jul;17(7):901-904

University of Washington Medical CenterSeattle, Washingtonand.

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http://dx.doi.org/10.1513/AnnalsATS.202002-126RLDOI Listing

Costs of Workplace Productivity Loss in Patients with Connective Tissue Disease Associated Interstitial Lung Disease.

Ann Am Thorac Soc 2020 May 21. Epub 2020 May 21.

University of British Columbia, Department of Medicine, Vancouver, British Columbia, Canada.

Rationale: Interstitial lung disease (ILD) develops in a large percentage of patients with connective tissue disease (CTD) and is associated with increased morbidity and mortality. Patients with CTD-associated ILD (CTD-ILD) often present at a young age, suggesting that ILD likely impacts workplace productivity.

Objectives: We aimed to determine the employment rate and workplace productivity loss, its associated factors, and its estimated costs in patients with fibrotic CTD-ILD. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201911-822OCDOI Listing

Reflux-Aspiration in Chronic Lung Disease.

Ann Am Thorac Soc 2020 May 21. Epub 2020 May 21.

Imperial College and Royal Brompton Hospital, London, London, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1513/AnnalsATS.202002-110LEDOI Listing

Longitudinal Health-Related Quality of Life among Individuals Considering Treatment for Stage I Non-Small Cell Lung Cancer.

Ann Am Thorac Soc 2020 May 20. Epub 2020 May 20.

Portland VA Medical Center, 20088, Center to Improve Veteran Involvement in Care, Portland, Oregon, United States.

Rationale: Due to improvements in screening, there is an increasing number of patients with early stage non-small cell lung cancer who are making treatment decisions.

Objectives: Among patients with suspected stage I non-small cell lung cancer (NSCLC), we evaluated longitudinal patient-centered outcomes (PCOs) and the association of changes in PCOs with treatment modality, stereotactic body radiotherapy (SBRT) compared to surgical resection.

Methods: We conducted a multi-site, prospective, observational cohort study at seven medical institutions. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202001-029OCDOI Listing

Reply: COVID-19 Lung Injury and "Typical" ARDS: The Danger of Presumed Equivalency.

Ann Am Thorac Soc 2020 May 20. Epub 2020 May 20.

University of Washington, Medicine, Seattle, Washington, United States.

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http://dx.doi.org/10.1513/AnnalsATS.202005-430LEDOI Listing

Respiratory Mechanics and Gas Exchange in COVID-19 Associated Respiratory Failure.

Ann Am Thorac Soc 2020 May 20. Epub 2020 May 20.

Weill Cornell Medical College, Pulmonary and Critical Care Medicine, New York, New York, United States.

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http://dx.doi.org/10.1513/AnnalsATS.202005-427RLDOI Listing

COVID-19 Lung Injury and "Typical" ARDS: The Danger of Presumed Equivalency.

Ann Am Thorac Soc 2020 May 20. Epub 2020 May 20.

Maimonides Medical Center, 2042, Emergency Medicine, Brooklyn, New York, United States;

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http://dx.doi.org/10.1513/AnnalsATS.202005-405LEDOI Listing

Hydroxychloroquine vs. Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS): Protocol for a Pragmatic, Open Label, Active Comparator Trial.

Ann Am Thorac Soc 2020 May 19. Epub 2020 May 19.

University of Utah School of Medicine, 12348, Study Design and Biostatistics Center and Division of Epidemiology, Salt Lake City, Utah, United States.

COVID-19 is a potentially fatal illness with no proven therapy beyond excellent supportive care. Treatments are urgently sought. Adaptations to traditional trial logistics and design to allow rapid implementation, evaluation of trials within a global trials context, flexible interim monitoring, and access outside traditional research hospitals (even in settings where formal placebos are unavailable) may be helpful. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202004-309SDDOI Listing

Intrapleural Fibrinolytic Therapy versus Early Medical Thoracoscopy for Treatment of Pleural Infection: Randomized Clinical Trial.

Ann Am Thorac Soc 2020 May 18. Epub 2020 May 18.

Beth Israel Deaconess Medical Center, 1859, Division of Thoracic Surgery and Interventional Pulmonology, Boston, Massachusetts, United States;

Rationale: Pleural infection is a frequent diagnosis encountered in clinical practice associated with high morbidity and mortality. Limited evidence exists regarding the optimal treatment. Although both early medical thoracoscopy (MT) and tube thoracostomy with intrapleural instillation of tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase) are acceptable treatment for patients with complicated pleural infection, there is a lack of comparative data between these modes of management. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202001-076OCDOI Listing

Correlation between Ivacaftor-induced CFTR Activation in Airway Epithelial Cells and Improved Lung Function: A Proof-of-Concept.

Ann Am Thorac Soc 2020 May 18. Epub 2020 May 18.

Seattle Children's Hospital, 7274, Pediatrics, Seattle, Washington, United States;

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http://dx.doi.org/10.1513/AnnalsATS.202001-082RLDOI Listing

Determinants of Evidence-Based Practice Uptake in Rural Intensive Care Units: A Mixed Methods Study.

Ann Am Thorac Soc 2020 May 18. Epub 2020 May 18.

Medical University of South Carolina - College of Medicine, 158155, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Charleston, South Carolina, United States.

Rationale: Evidence-based practices promote quality care for intensive care unit patients but chronic evidence-to-practice gaps limit their reach.

Objective: To characterize key determinants of evidence-based practice uptake in the rural intensive care setting.

Methods: A parallel convergent mixed methods design was used with 6 hospitals receiving a quality improvement intervention. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202002-170OCDOI Listing