9,932 results match your criteria Annals of surgical oncology[Journal]


Digital Breast Tomosynthesis for Intraoperative Margin Assessment during Breast-Conserving Surgery.

Ann Surg Oncol 2019 Mar 14. Epub 2019 Mar 14.

Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Intraoperative margin assessment for breast cancer patients undergoing segmental mastectomy (SM) enables identification of positive margins, with immediate excision of additional tissue to obtain negative margins.

Objective: The aim of this study was to determine the ability of digital breast tomosynthesis (DBT) to detect positive margins compared with an institution's standard extensive processing (SEP).

Methods: SM specimens underwent intraoperative SEP with two-dimensional (2D) imaging of the intact and sliced specimen, with review by a breast radiologist and gross assessment by a breast pathologist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07226-wDOI Listing

Diagnostic Accuracy and Usefulness of Intraoperative Margin Assessment by Frozen Section in Gastric Cancer.

Ann Surg Oncol 2019 Mar 14. Epub 2019 Mar 14.

Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan.

Background: Intraoperative frozen examination is clinically important for negative margin confirmation in cancer surgery. We investigated the diagnostic accuracy of frozen-section assessment and risk factors for positive resection margins by studying gastric cancer specimens from 1115 patients treated at our hospital.

Methods: The results of gastric cancer patients who had undergone intraoperative margin assessment, employing frozen examination, with curative intent in our unit between 2000 and 2017 were retrospectively analyzed. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1245/s10434-019-07302-1
Publisher Site
http://dx.doi.org/10.1245/s10434-019-07302-1DOI Listing
March 2019
1 Read

Association of Perioperative Transfusion with Recurrence and Survival After Resection of Distal Cholangiocarcinoma: A 10-Institution Study from the US Extrahepatic Biliary Malignancy Consortium.

Ann Surg Oncol 2019 Mar 15. Epub 2019 Mar 15.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Background: Perioperative allogeneic blood transfusion is associated with poor oncologic outcomes in multiple malignancies. The effect of blood transfusion on recurrence and survival in distal cholangiocarcinoma (DCC) is not known.

Methods: All patients with DCC who underwent curative-intent pancreaticoduodenectomy at 10 institutions from 2000 to 2015 were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07306-xDOI Listing
March 2019
1 Read

Response to: "Intact Excision of Breast Lesions Using BLES™: Is There a Clinical Indication Yet?"

Authors:
Pat Whitworth

Ann Surg Oncol 2019 Mar 15. Epub 2019 Mar 15.

Nashville Breast Center, Nashville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07317-8DOI Listing

Impact of Synchronous Versus Metachronous Onset of Colorectal Peritoneal Metastases on Survival Outcomes After Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Multicenter, Retrospective, Observational Study.

Ann Surg Oncol 2019 Mar 15. Epub 2019 Mar 15.

Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Careful selection of patients with colorectal peritoneal metastases (PM) for cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is crucial. It remains unknown whether the time of onset of colorectal PM (synchronous vs metachronous) influences surgical morbidity and survival outcomes after CRS with HIPEC.

Methods: Patients with histologically proven colorectal PM who underwent CRS with HIPEC between February 2006 and December 2017 in two Dutch tertiary referral hospitals were retrospectively included from a prospectively maintained database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07294-yDOI Listing
March 2019
1 Read

Neoadjuvant Chemotherapy with Gemcitabine Plus Nab-Paclitaxel for Borderline Resectable Pancreatic Cancer Potentially Improves Survival and Facilitates Surgery.

Ann Surg Oncol 2019 Mar 13. Epub 2019 Mar 13.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Accumulation of evidence suggests that neoadjuvant chemotherapy improves the outcomes of borderline resectable pancreatic cancer (BRPC). Gemcitabine plus nab-paclitaxel (GnP) has been widely accepted as systemic chemotherapy for unresectable pancreatic cancer and reportedly results in remarkable tumor shrinkage. This study was performed to evaluate the safety and efficacy of neoadjuvant chemotherapy using neoadjuvant GnP for BRPC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07309-8DOI Listing

Comment on: "Early Outcomes of Robot-Assisted Versus Thoracoscopic-Assisted Ivor Lewis Esophagectomy for Esophageal Cancer: A Propensity Score-Matched Study".

Ann Surg Oncol 2019 Mar 13. Epub 2019 Mar 13.

Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07310-1DOI Listing

Defining Tumor Rupture in Gastrointestinal Stromal Tumor.

Ann Surg Oncol 2019 Mar 13. Epub 2019 Mar 13.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.

Tumor rupture is an important risk factor predictive of recurrence after macroscopically complete resection of gastrointestinal stromal tumors (GISTs), and an indication for defined interval or even lifelong adjuvant therapy with imatinib according to guidelines. However, there is no consensus or universally accepted definition of the term 'tumor rupture', and, consequently, its incidence varies greatly across reported series. Without predefined criteria, the clinical significance of rupture has also been difficult to assess on multivariate analysis of retrospective data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07297-9DOI Listing
March 2019
1 Read

Effect of Resection of the Thoracic Duct and Surrounding Lymph Nodes on Short- and Long-Term and Nutritional Outcomes After Esophagectomy for Esophageal Cancer.

Ann Surg Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Background: The effect of resection of the thoracic duct (TD) along with surrounding lymph nodes (LN) on short- and long-term outcomes of esophagectomy in esophageal cancer patients is not well defined.

Methods: A total of 537 consecutive patients suffering from esophageal cancer who underwent three-incision esophagectomy between April 2005 and August 2018 were eligible for short-term outcome analysis. Among them, 487 patients who underwent surgery before August 2017 were eligible for analysis of long-term outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07304-zDOI Listing

Effects of Antihypertensive Drugs on Outcomes of Breast Reconstruction.

Ann Surg Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: Angiotensin receptor blocker (ARB), a commonly used antihypertensive drug, is reported to affect wound healing and flap survival in animal models. However, this has not been elucidated in a clinical series. This study aimed to investigate the impact that perioperative use of ARB has on outcomes after breast reconstruction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07293-zDOI Listing

Surgery for Pancreatic Neuroendocrine Tumor G3 and Carcinoma G3 Should be Considered Separately.

Ann Surg Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan.

Background: The role of surgery in pancreatic neuroendocrine neoplasm grade 3 (pNEN-G3) treatment remains unclear. We aimed to clarify the role of surgery for pNEN-G3, which has recently been reclassified as pancreatic neuroendocrine tumor-G3 (pNET-G3) and pancreatic neuroendocrine carcinoma-G3 (pNEC-G3), with and without metastases, respectively.

Methods: We analyzed a subgroup of patients from the Japanese pancreatic NEC study, a Japanese multicenter case-series study of pNEN-G3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07252-8DOI Listing
March 2019
2 Reads

Borderline and Malignant Phyllodes Tumors: How Often do They Locally Recur and is There Anything we can do About it?

Authors:
Richard J Barth

Ann Surg Oncol 2019 Mar 12. Epub 2019 Mar 12.

Department of Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07278-yDOI Listing

ASO Author Reflections: Challenges in the Management of Young Women with Breast Cancer-Fertility Preservation and Pregnancy.

Ann Surg Oncol 2019 Mar 11. Epub 2019 Mar 11.

Division of Surgical Oncology, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07285-zDOI Listing

ASO Author Reflections: Temporary Mesocaval Shunt: Indications and Technique for Safe Resection of Pancreatic Tumors With Mesenteric Venous Occlusion.

Ann Surg Oncol 2019 Mar 11. Epub 2019 Mar 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07290-2DOI Listing

Low Risk of Development of a Regional Recurrence After an Unsuccessful Repeat Sentinel Lymph Node Biopsy in Patients with Ipsilateral Breast Tumor Recurrence.

Ann Surg Oncol 2019 Mar 8. Epub 2019 Mar 8.

Department of Surgery, Catharina Hospital Eindhoven, 5623 EJ, Eindhoven, The Netherlands.

Background: Unlike sentinel lymph node biopsy (SLNB) in the primary setting, the repeat SLNB (rSLNB) in patients with ipsilateral breast tumor recurrence (IBTR) is challenging, because it is difficult to visualize and/or harvest a sentinel lymph node in every patient. Regional treatments options and safety in terms of regional disease control after such an unsuccessful rSLNB remain unclear. This study assesses factors associated with the performance of axillary lymph node dissection (ALND) after unsuccessful rSLNB and evaluates the occurrence of regional recurrences. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07272-4DOI Listing
March 2019
1 Read

Long-Term Outcomes Following Partial Versus Complete Cystectomy in Advanced Colorectal Cancer with Regarding to the Extent of Bladder Invasion.

Ann Surg Oncol 2019 Mar 7. Epub 2019 Mar 7.

Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.

Background: Two procedures widely performed to treat locally advanced colorectal cancer adherent to the urinary bladder are total cystectomy (as part of pelvic exenteration) and partial cystectomy; however, little is known about outcomes following partial cystectomy.

Methods: A retrospective database of patients with colorectal cancer involving the urinary bladder who underwent R0 or R1 resection at our institution from 2001 to 2015 was constructed. The histological extent of bladder invasion and long-term outcomes were examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07276-0DOI Listing
March 2019
1 Read

Transanal Minimally Invasive Surgery (TAMIS) for Large Rectal Polyps.

Ann Surg Oncol 2019 Mar 7. Epub 2019 Mar 7.

Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07171-8DOI Listing
March 2019
3.930 Impact Factor

ASO Author Reflections: Similar Short- and Long-Term Outcomes in Variable Use and Timing of Restaging MRI and Surgery After Preoperative Chemoradiotherapy for Rectal Cancer.

Ann Surg Oncol 2019 Mar 7. Epub 2019 Mar 7.

Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07286-yDOI Listing

Light Up the Tissue and Brighten Your Patients' Odds.

Ann Surg Oncol 2019 Mar 7. Epub 2019 Mar 7.

Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07280-4DOI Listing

Impact of Anatomical Versus Non-anatomical Liver Resection on Short- and Long-Term Outcomes for Patients with Intrahepatic Cholangiocarcinoma.

Ann Surg Oncol 2019 Mar 6. Epub 2019 Mar 6.

Department of Hepatic Surgery IV, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Objective: The aim of this study was to examine the impact of anatomical resection (AR) versus non-anatomical resection (NAR) on the survival outcomes in patients with intrahepatic cholangiocarcinoma (ICC).

Patients And Methods: Data on 702 consecutive patients who underwent either AR (n = 319) or NAR (n = 383) for ICC were reviewed. Disease-free survival (DFS) and overall survival (OS) following AR versus NAR was compared using propensity score matching (PSM). Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1245/s10434-019-07260-8
Publisher Site
http://dx.doi.org/10.1245/s10434-019-07260-8DOI Listing
March 2019
2 Reads
3.930 Impact Factor

Systematic Review of Surgical and Percutaneous Irreversible Electroporation in the Treatment of Locally Advanced Pancreatic Cancer.

Ann Surg Oncol 2019 Mar 6. Epub 2019 Mar 6.

Department of Surgery, The Urban Meyer III and Shelley Meyer Chair for Cancer Research, Wexner Medical Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA.

Objective: The aim of the present systematic review was to collect, analyze, and critically evaluate the role of irreversible electroporation (IRE) in locally advanced pancreatic cancer (LAPC). Furthermore, we sought to analyze the different approaches of IRE (open, laparoscopic, and percutaneous) and assess the relative outcomes.

Methods: A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07261-7DOI Listing
March 2019
1 Read

Thirty Years of Counting Cancer Cases: The Collective Effort and Efficacy of the National Cancer Database.

Ann Surg Oncol 2019 Mar 6. Epub 2019 Mar 6.

Surgical Outcomes and Quality Improvement Center (SOQIC), Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07215-zDOI Listing

Early Outcomes of Robot-Assisted Versus Thoracoscopic-Assisted Ivor Lewis Esophagectomy for Esophageal Cancer: A Propensity Score-Matched Study.

Ann Surg Oncol 2019 Mar 6. Epub 2019 Mar 6.

Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Both robot-assisted Ivor Lewis esophagectomy (RAILE) and conventional thoracoscopic-assisted Ivor Lewis esophagectomy (TAILE) are minimally invasive surgical techniques for the treatment of middle and distal esophageal cancer. However, no research studies comparing early outcomes between RAILE and TAILE have been reported.

Methods: A retrospective analysis was made of 184 patients, 76 in the RAILE group and 108 in the TAILE group, who underwent minimally invasive Ivor Lewis esophagectomy between December 2014 and June 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07273-3DOI Listing

Preoperative Pazopanib in High-Risk Soft Tissue Sarcoma: Phase II Window-of Opportunity Study of the German Interdisciplinary Sarcoma Group (NOPASS/GISG-04).

Ann Surg Oncol 2019 Mar 6. Epub 2019 Mar 6.

Division of Surgical Oncology and Thoracic Surgery, University Medical Center Mannheim, Mannheim, Germany.

Background: Preoperative devascularization might improve local control and thus the outcome of patients with soft tissue sarcoma (STS). The multikinase inhibitor pazopanib has antiangiogenic effects and is approved for treating metastatic STS. We conducted a trial of preoperative pazopanib therapy in high-risk STS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07183-4DOI Listing

ASO Author Reflections: Pelvic Exenteration for Patients with Primary and Recurrent Pelvic Cancer.

Authors:
Yakup Kulu

Ann Surg Oncol 2019 Mar 6. Epub 2019 Mar 6.

University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07282-2DOI Listing
March 2019
1 Read

ASO Author Reflections: Intraoperative Fluid Restriction During CRS-HIPEC-Less is More.

Ann Surg Oncol 2019 Mar 5. Epub 2019 Mar 5.

Division of Surgical Oncology, Department of Surgery, University of Massachusetts Medical School, Worcester, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07283-1DOI Listing

Breast-Contour-Preserving Procedure as a Multidisciplinary Parameter of Esthetic Outcome in Breast Cancer Treatment in The Netherlands.

Ann Surg Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgery, Diakonessenhuis Utrecht, Utrecht, The Netherlands.

Background: The rate of breast-conserving surgery (BCS) is used as an esthetic outcome parameter, while other treatments contribute also, such as neoadjuvant chemotherapy (NAC) enabling BCS or immediate breast reconstruction (IBR). This study explores these efforts to preserve the patient's breast contour.

Patients And Methods: All patients who underwent surgery for invasive breast cancer in The Netherlands between January 2011 and December 2015 were selected from the Dutch national breast cancer audit (n = 61,309). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07265-3DOI Listing

Early Recurrence in Completely Resected IIIB and IIIC Melanoma Warrants Restaging Prior to Adjuvant Therapy.

Ann Surg Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

Purpose: To evaluate the results of restaging completely resected stage IIIB/C melanoma prior to start of adjuvant therapy.

Patients And Methods: One hundred twenty patients with stage IIIB or IIIC (AJCC 2009) melanoma who underwent complete surgical resection were screened for inclusion in our trial investigating adjuvant dendritic cell therapy (NCT02993315). All patients underwent imaging to exclude local relapse or metastasis before entering the trial. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1245/s10434-019-07274-2
Publisher Site
http://dx.doi.org/10.1245/s10434-019-07274-2DOI Listing
March 2019
1 Read

Risk of Recurrence in Differentiated Thyroid Cancer: A Population-Based Comparison of the 7th and 8th Editions of the American Joint Committee on Cancer Staging Systems.

Ann Surg Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgery, College of Medicine, University of Kentucky, Lexington, KY, USA.

Background: Differentiated thyroid cancer (DTC) survival is excellent, making recurrence a more clinically relevant prognosticator. We hypothesized that the new American Joint Committee on Cancer (AJCC) 8th edition improves on the utility of the 7th edition in predicting the risk of recurrence in DTC.

Methods: A population-based retrospective review compared the risk of recurrence in patients with DTC according to the AJCC 7th and 8th editions using the Surveillance, Epidemiology, and End Results-based Kentucky Cancer Registry from 2004 to 2012. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1245/s10434-019-07275-1
Publisher Site
http://dx.doi.org/10.1245/s10434-019-07275-1DOI Listing
March 2019
1 Read

Prospective Evaluation of Residual Breast Tissue After Skin- or Nipple-Sparing Mastectomy: Results of the SKINI-Trial.

Ann Surg Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Breast Surgery, Brust-Zentrum, Zurich, Switzerland.

Objective: This study was designed to investigate the presence of residual breast tissue (RBT) after skin-sparing mastectomy (SSM) and nipple-sparing mastectomy (NSM) and to analyse patient- and therapy-related factors associated with RBT. Skin-sparing mastectomy and NSM are increasingly used surgical procedures. Prospective data on the completeness of breast tissue resection is lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07259-1DOI Listing
March 2019
2 Reads

Fluorescent Tissue Assessment of Colorectal Cancer Liver Metastases Ablation Zone: A Potential Real-Time Biomarker of Complete Tumor Ablation.

Ann Surg Oncol 2019 Mar 4. Epub 2019 Mar 4.

Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: This study aimed to evaluate whether rapid fluorescent tissue examination immediately after colorectal cancer liver metastasis (CLM) ablation correlates with standard pathologic and immunohistochemical (IHC) assessments.

Methods: This prospective, National Institutes of Health-supported study enrolled 34 consecutive patients with 53 CLMs ablated between January 2011 and December 2014. Immediately after ablation, core needle sampling of the ablation zone was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-018-07133-6DOI Listing
March 2019
1 Read

Long-Term Outcome After Retro-Areolar Versus Peri-Tumoral Injection of Superparamagnetic Iron Oxide Nanoparticles (SPIO) for Sentinel Lymph Node Detection in Breast Cancer Surgery.

Ann Surg Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Background/objective: SPIO is effective in sentinel node (SN) detection. No nuclear medicine department is needed, and no allergic reactions have occurred. This study aimed to compare retro-areolar and peri-tumoral SPIO injections regarding skin staining, detection rates and number of SNs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07239-5DOI Listing

Elective Paratracheal Lymph Node Dissection in Salvage Laryngectomy.

Ann Surg Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.

Background: Indications for and efficacy of paratracheal nodal dissection (PTND) in patients undergoing laryngectomy (salvage) for persistent or recurrent laryngeal squamous cell carcinoma are not well-defined.

Methods: A retrospective cohort study was performed for patients undergoing salvage laryngectomy with clinically and radiographically negative neck disease between 1998 and 2015 (n = 210). Univariate and multivariate Cox regression analyses were performed. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1245/s10434-019-07270-6
Publisher Site
http://dx.doi.org/10.1245/s10434-019-07270-6DOI Listing
March 2019
4 Reads

Repeat Cytoreductive Surgery-Hyperthermic Intraperitoneal Chemoperfusion is Feasible and Offers Survival Benefit in Select Patients with Peritoneal Metastases.

Ann Surg Oncol 2019 Mar 1. Epub 2019 Mar 1.

Division of Surgical Oncology, Koch Regional Perfusion Center, University of Pittsburgh, Pittsburgh, PA, USA.

Introduction: We hypothesized that repeat cytoreductive surgery-hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC) for peritoneal metastases (PM) may be associated with suboptimal resection, more frequent postoperative complications, and worse oncologic outcomes.

Methods: Using a prospectively maintained database, we compared clinicopathologic, perioperative, and oncologic outcome data in patients undergoing single or repeat CRS-HIPEC procedures. The Kaplan-Meier method was used to estimate survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07218-wDOI Listing

Pancreatic Juice Exosomal MicroRNAs as Biomarkers for Detection of Pancreatic Ductal Adenocarcinoma.

Ann Surg Oncol 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal neoplasm because of difficulties in early detection. Several studies have recently suggested that exosomes may have potential as novel biomarkers. This study aimed to isolate exosomes from pancreatic juice and to investigate whether exosomal microRNAs (ex-miRs) could be used as biomarkers for PDAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07269-zDOI Listing
February 2019
1 Read

Exosomes from Pancreatic Juice: A Step Closer to the Holy Grail?

Authors:
Andrew M Lowy

Ann Surg Oncol 2019 Feb 28. Epub 2019 Feb 28.

Moores Cancer Center, University of California, San Diego, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07271-5DOI Listing
February 2019

Intrahepatic Cholangiocarcinoma: Rising Burden and Glaring Disparities.

Ann Surg Oncol 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07176-3DOI Listing
February 2019
1 Read

Prognostic Effect of TP53 and PKD Co-Mutations in Patients with Resected Epidermal Growth Factor Receptor-Mutated Lung Adenocarcinoma.

Ann Surg Oncol 2019 Feb 28. Epub 2019 Feb 28.

Department of Thoracic Surgery, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.

Background: The impact of specific co-mutations in epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma is unclear.

Methods: Tissues from 147 consecutive patients with resected EGFR-mutated lung adenocarcinomas treated at Sun Yat-Sen University Cancer Center were analyzed by next-generation sequencing (NGS). Associations between mutation status, patient baseline characteristics, and survival outcomes (disease-free survival [DFS] and overall survival [OS]) after surgical resection were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07254-6DOI Listing
February 2019
1 Read

Long-Term Efficacy of Lymph Node Reoperation for Persistent Papillary Thyroid Cancer: 13-Year Follow-Up.

Ann Surg Oncol 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital, Columbus, OH, USA.

Background: Current recommendations for persistent or recurrent locoregional papillary thyroid cancer (PTC) include consideration of surgical resection versus active surveillance. The purpose of this study is to determine long-term outcomes after surgical resection of recurrent or persistent metastatic PTC in cervical lymph nodes after failure of initial surgery and radioactive iodine therapy using newer validated clinical outcomes measures.

Methods: Outcomes of 70 patients who underwent cervical lymphadenectomy (n = 110) from 1999 to 2013 for recurrent or persistent locoregional PTC metastases were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07263-5DOI Listing
February 2019
1 Read

A Clinicopathological and Prognostic Analysis of PD-L2 Expression in Surgically Resected Primary Lung Squamous Cell Carcinoma.

Ann Surg Oncol 2019 Feb 27. Epub 2019 Feb 27.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Immunotherapy targeting programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) has shown dramatic therapeutic effects for lung squamous cell carcinoma (SCC), and PD-L1 expression has been shown not only to be a predictive biomarker for response to immunotherapy but also a prognostic factor for lung SCC. However, the clinical significance of programmed death-ligand 2 (PD-L2), another PD-1 ligand, remains unclear. Therefore, we analyzed PD-L2 expression by immunohistochemistry in surgically resected primary lung SCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07257-3DOI Listing
February 2019

Does Primary Tumor Side Matter in Patients with Metastatic Colon Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy?

Ann Surg Oncol 2019 Feb 27. Epub 2019 Feb 27.

Department of Surgery, Division of Surgical Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.

Background: Primary tumor location has been shown to be prognostic of overall survival (OS) in patients with both locally advanced and metastatic colorectal cancer. The impact of sidedness on prognosis has not been evaluated in the setting of peritoneal-only metastases treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).

Methods: A retrospective review of prospectively maintained databases of patients with peritoneal surface malignancy undergoing CRS/HIPEC from three high-volume centers was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07255-5DOI Listing
February 2019
1 Read

Prognostic Impact of Programmed Death-Ligand 2 Expression in Primary Lung Adenocarcinoma Patients.

Ann Surg Oncol 2019 Feb 27. Epub 2019 Feb 27.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Programmed death-ligand 1 (PD-L1) expression on lung cancer cells is a prognostic marker and a predictive biomarker for response to immunotherapy. However, previous clinical trials have suggested that other programmed cell death 1 ligands, including programmed death-ligand 2 (PD-L2), might have clinical impacts. This study aimed to analyze the prognostic significance of PD-L2 expression in lung adenocarcinoma patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07231-zDOI Listing
February 2019

Chemoprevention Uptake for Breast Cancer Risk Reduction Varies by Risk Factor.

Ann Surg Oncol 2019 Feb 27. Epub 2019 Feb 27.

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background/objective: The efficacy of chemoprevention for breast cancer risk reduction has been demonstrated in randomized controlled trials; however, use remains low. We sought to determine whether uptake differed by risk factors, and to identify reasons for refusal and termination.

Methods: Women seen in a high-risk clinic from October 2014 to June 2017 considered eligible for chemoprevention (history of lobular carcinoma in situ, atypia, family history of breast/ovarian cancer, genetic mutation, or history of chest wall radiation) were retrospectively identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07236-8DOI Listing
February 2019

Intraoperative Fluorescent Angiography Predicts Pharyngocutaneous Fistula After Salvage Laryngectomy.

Ann Surg Oncol 2019 Feb 25. Epub 2019 Feb 25.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health Center, Ann Arbor, MI, USA.

Background: Technology to assess tissue perfusion is exciting with translational potential, although data supporting its clinical applications have been lagging. Patients who have undergone radiation are at particular risk of poor tissue perfusion and would benefit from this expanding technology. We designed a prospective clinical trial using intraoperative indocyanine green angiography to evaluate for wound-healing complications in patients undergoing salvage laryngectomy after radiation failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07262-6DOI Listing
February 2019
1 Read

Cellular Senescence, Represented by Expression of Caveolin-1, in Cancer-Associated Fibroblasts Promotes Tumor Invasion in Pancreatic Cancer.

Ann Surg Oncol 2019 Feb 25. Epub 2019 Feb 25.

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan.

Background: The role of senescence of cancer-associated fibroblasts (CAFs) in the development of cancer is controversial. In this study, we investigated whether cellular senescence of CAFs, represented by CAV1 expression, affects tumor progression in pancreatic cancers (PC).

Methods: Because CAV1 plays a major role in cellular senescence, we used CAV1 expression to monitor cellular senescence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07266-2DOI Listing
February 2019

Concurrent Selective Lymph Node Radiotherapy and S-1 Plus Cisplatin for Esophageal Squamous Cell Carcinoma: A Phase II Study.

Ann Surg Oncol 2019 Feb 25. Epub 2019 Feb 25.

Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, People's Republic of China.

Background: The efficacy, toxicity, and patterns of failure of esophageal squamous cell carcinoma (ESCC) treated with selective lymph node (SLN) conventional fraction radiotherapy (CFRT) and S-1 plus cisplatin (CDDP) were evaluated.

Patients And Methods: 67 Patients with clinical stage II-IVa ESCC were enrolled. The total dose of SLN CFRT was 60 Gy in 30 fractions over 6 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07264-4DOI Listing
February 2019
2 Reads

Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1-3 Colon Cancer: A Meta-Analysis.

Ann Surg Oncol 2019 Feb 25. Epub 2019 Feb 25.

Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Jeonbuk, South Korea.

Background: Previous studies comparing the oncologic outcomes of primary tumor-sidedness for patients with colon cancer have reported a worse prognosis for those with right-sided tumors. However, most of these studies evaluated patients with metastatic disease.

Methods: PubMed, EMBASE, and the Cochrane Library were searched for studies that assessed the effects of primary tumor-sidedness on survival outcomes for patients with stages 1, 2, and 3 colon cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07164-7DOI Listing
February 2019