763 results match your criteria Annals of palliative medicine[Journal]


Investigation of COVID-19-related symptoms based on factor analysis.

Ann Palliat Med 2020 Jun 22. Epub 2020 Jun 22.

Jingzhou Hospital of Traditional Chinese Medicine, Jingzhou 434000, China.

Background: The application of factor analysis in the study of the clinical symptoms of coronavirus disease 2019 (COVID-19) was investigated, to provide a reference for basic research on COVID-19 and its prevention and control.

Methods: The data of 60 patients with COVID-19 in Jingzhou Hospital of Traditional Chinese Medicine and the Second People's Hospital of Longgang District in Shenzhen were extracted using principal component analysis. Factor analysis was used to investigate the factors related to symptoms of COVID-19. Read More

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http://dx.doi.org/10.21037/apm-20-1113DOI Listing

The poor prognosis of lower-inner quadrant breast cancer in patients who received neoadjuvant chemotherapy.

Ann Palliat Med 2020 Jun 18. Epub 2020 Jun 18.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, China.

Background: The elevated risk for recurrence in breast cancer patients after receiving neoadjuvant chemotherapy (NAC) is still controversial. The purpose of this paper was to investigate the prognostic significance of tumor location concerning the survival of patients with breast cancer treated with NAC.

Methods: The clinical information of 676 patients with stage II-III breast carcinoma who were being treated with NAC between March 2009 and 2014 was investigated. Read More

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http://dx.doi.org/10.21037/apm-20-1140DOI Listing

H subtype vascular endothelial cells in human femoral head: an experimental verification.

Ann Palliat Med 2020 Jun 22. Epub 2020 Jun 22.

Department of Orthopedics, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing, China.

Background: Osteonecrosis of the femoral head (ONFH) is difficult to treat, and leads to an impaired microcirculation of the femoral head and activation of a repair response. The type H vessels have been proved to mediate the growth of the bone vasculature and couple angiogenesis to osteogenesis. The aim of the study is to investigate the experimental verification of H subtype vascular endothelial cells (HSVECs) in the human femoral head. Read More

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http://dx.doi.org/10.21037/apm-20-121DOI Listing

Ultrasonic examination of differences in bone density of chronic obstructive pulmonary disease (COPD) rats constructed by different methods.

Ann Palliat Med 2020 Jun 15. Epub 2020 Jun 15.

Medical Oncology, Huzhou Traditional Chinese Medicine Hospital, Affiliated to Zhejiang Chinese Medical University, Huzhou 313000, China.

Background: Osteoporosis is one of the main complications of chronic obstructive pulmonary disease (COPD) patients. We investigated the bone density in rat model of COPD induced by different method.

Methods: We developed seven distinct groups to evaluate the differences in bone density. Read More

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http://dx.doi.org/10.21037/apm-20-1047DOI Listing

Practice and reflection on the management mode of pain quality control in emergency pre-check and triage.

Ann Palliat Med 2020 Jun 22. Epub 2020 Jun 22.

The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.

Background: Triage decision making is crucial for patients arrived at emergency room as it influences the clinical outcome. Appropriate standard to discriminate patients into different category is challenging. We introduced a suitable emergency preview triage pain model for quality management methods through the pain assessment module. Read More

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http://dx.doi.org/10.21037/apm-20-1108DOI Listing

Current status of ex-vivo liver resection and autologous liver transplantation for end-stage hepatic alveolar echinococcosis.

Ann Palliat Med 2020 Jun 12. Epub 2020 Jun 12.

Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province & Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Hepatic alveolar echinococcosis (HAE) is a cosmopolitan zoonosis distribute widely in the northern hemisphere with high estimated 10-year mortality. Radical resection combined with oral albendazole administration are the major methods for HAE treatment, whereas most patients delayed diagnosis and treatment because which was considered as benign disease. For the cases with end-stage HAE could not be treated through conventional hepatectomy, allograft liver transplantation (LT) was regarded as a life-saving technique previously. Read More

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http://dx.doi.org/10.21037/apm-20-184DOI Listing

Barriers to inpatient palliative care consultation among patients with newly diagnosed cancer after emergency admission.

Ann Palliat Med 2020 Jun 17. Epub 2020 Jun 17.

Tsukuba Medical Center Hospital, Department of Palliative Medicine, Tsukuba, Japan.

Background: Many patients with advanced cancer diagnosed following emergency presentation will likely benefit from palliative care (PC) interventions. This study assessed the potential patient-related barriers to inpatient PC consultation among patients who were newly diagnosed with cancer after emergency admission (EA) and received only supportive care.

Methods: This observational study retrospectively obtained data on all patients who were admitted to our hospital after emergency transfer between January 2012 and November 2016. Read More

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http://dx.doi.org/10.21037/apm-19-504DOI Listing

Gastrolithiasis with incomplete intestinal obstruction in the perioperative period of percutaneous transluminal coronary intervention: one case report.

Ann Palliat Med 2020 Jun 15. Epub 2020 Jun 15.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Gastrolithiasis is one of the uncommon clinical diseases with low incidence and its clinical manifestations are not typical. It is easy to be ignored when combined with other medical diseases. In this paper we present a case of gastrolithiasis just after percutaneous transluminal coronary intervention (PCI), the patient suffered from unexplained persistent abdominal distention and pain with gastric retention, nausea and vomiting. Read More

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http://dx.doi.org/10.21037/apm-20-467DOI Listing

A meta-analysis of clinical efficacy and quality of life of cognitive-behavioral therapy in acute coronary syndrome patients with anxiety and depression.

Ann Palliat Med 2020 Jun 10. Epub 2020 Jun 10.

Department of Nephrology, the First Affiliated Hospital of Chengdu Medical College, Chengdu, China.

Background: Our study aims to evaluate the clinical efficacy and quality of life of cognitive-behavioral therapy (CBT) for patients who have acute coronary syndrome (ACS) with anxiety and depression.

Methods: The databases of PubMed, Cochrane, and Web of science, as well as China journal full-text database, Wanfang database, and Weipu database, were systematically searched from the establishment of the database to February 29, 2020. The total effective rate of qualitative data was evaluated with a relative risk (RR) and 95% confidence interval (CI), and the quantitative data was evaluated with a standard mean difference (SMD) and 95% CI. Read More

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http://dx.doi.org/10.21037/apm-20-974DOI Listing

Regulation of lncRNA-H19/miR-140-5p in cartilage matrix degradation and calcification in osteoarthritis.

Ann Palliat Med 2020 Jun 16. Epub 2020 Jun 16.

Department of Nephrology Endocrinology and Rheumatology, The 960th Hospital of the Chinese People's Liberation Army, Zibo 255300, China.

Background: To study the effect of long non-coding RNA H19/microRNA (miR)-140-5p regulatory axis on the degradation and calcification of osteoarthritis (OA) cartilage matrix.

Methods: Twenty cases of clinical OA cartilage tissue and healthy cartilage tissue were collected. Construction of small interfering RNA vector (si-H19) and negative control (si-Control), miR-140-5p mimic and negative control mimic-NC, miR-140-5p inhibitor, and negative control inhibitor-NC transfected human chondrocytes HC-A cells. Read More

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http://dx.doi.org/10.21037/apm-20-929DOI Listing

Effects of atorvastatin combined with bivalirudin on coagulation function, cardiac function, and inflammatory factors of percutaneous coronary intervention in elderly patients with acute myocardial infarction.

Ann Palliat Med 2020 Jun 22. Epub 2020 Jun 22.

Department of Cardiology, Joint Logistic Support Force of Chinese People's Liberation Army Tianjin Rehabilitation and Recuperation Center, Tianjin 300381, China.

Background: Acute myocardial infarction (AMI) occurs when atherosclerotic lesions which present in the coronary arteries cause the intravascular plate to rupture and with the result of myocardial ischemia, hypoxia, and infarct. The preferred treatment for AMI is currently percutaneous coronary intervention (PCI), for which the key to the success is the choice of anticoagulant and thrombolytic drugs during surgery. Here, we aim to explore the effects of atorvastatin combined with bivalirudin on coagulation function, cardiac function, and inflammatory factors in elderly patients with AMI who underwent PCI. Read More

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http://dx.doi.org/10.21037/apm-20-925DOI Listing

Efficacy and safety of gemcitabine plus capecitabine in the treatment of advanced or metastatic pancreatic cancer: a systematic review and meta-analysis.

Ann Palliat Med 2020 Jun 22. Epub 2020 Jun 22.

Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai , China.

Background: Gemcitabine combined the oral fluoropyrimidine capecitabine (GemCap) is an active antitumor therapy in the treatment of advanced or metastatic pancreatic cancer, and has been shown potential synergistic activity in previous clinical trials. In this study, we sought to systematically review and synthesize the efficacy and safety of GemCap in the treatment of advanced or metastatic pancreatic cancer.

Methods: A systematic review was performed through PubMed, Cochrane Library, EMBASE, and Web of Science databases up to Jul 10, 2019 to identify clinical trials that included advanced or metastatic pancreatic cancer patients treated with GemCap. Read More

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http://dx.doi.org/10.21037/apm-20-45DOI Listing

Application of an education model using the WeChat public platform in the standardized training of anesthesiology residents.

Ann Palliat Med 2020 Jun 15. Epub 2020 Jun 15.

Department of Anesthesiology, Shanghai General Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, China.

Background: Standardized training of clinical residents is an important way to train high-level clinicians and is an important step to ensure quality clinical work. WeChat facilitates efficient information dissemination and feedback, convenient communication. In the new media era, the influence of WeChat has inspired changes in educational methods, to explore the role of an education model using the WeChat public platform in the standardized training of anesthesiology residents. Read More

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http://dx.doi.org/10.21037/apm-19-390DOI Listing

Analysis of chemical consistency and the anti-tumor activity of Huangqi-Ezhu (HQ-EZ) concentrated-granules and decoction.

Ann Palliat Med 2020 Jun 18. Epub 2020 Jun 18.

Beijing Institute of Radiation Medicine, Beijing, China.

Background: Traditional Chinese medicine decoction and modern concentrated-granules are two kinds of Chinese herbal medicine forms used in clinic at present. The former is extracted by traditional boiling method of a pre-mixed multi-herbal medicine according to the doctor's prescription. The latter is a mixture of extract active ingredients from a single variety of herbs by modern technology. Read More

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http://dx.doi.org/10.21037/apm-19-592DOI Listing

Acinar with ductal and mucinous adenocarcinoma of prostate cancer complicated with lung metastasis: a case report and literature review.

Ann Palliat Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Acinar adenocarcinoma, ductal adenocarcinoma and mucinous adenocarcinoma are the subtypes of prostate cancer (PCa). Most of the pathological types of PCa are acinar adenocarcinoma, while ductal adenocarcinoma and mucinous adenocarcinoma are uncommon. The case of acinar adenocarcinoma with ductal and mucinous adenocarcinoma has not been reported before. Read More

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http://dx.doi.org/10.21037/apm-20-386DOI Listing

Drug treatment of ankylosing spondylitis and related complications: an overlook review.

Ann Palliat Med 2020 Jun 15. Epub 2020 Jun 15.

School of Pharmacy, Inner Mongolia Medical University, Hohhot, China.

Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by back pain and progressive spinal stiffness. The prevalence of AS is 30 per 10,000 people. The patients often have complications or co-existing diseases, which may affect the choice of drugs and the treatment effects. Read More

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http://dx.doi.org/10.21037/apm-20-277DOI Listing

Microbial quantitation of colostrum from healthy breastfeeding women and milk from mastitis patients.

Ann Palliat Med 2020 Jun 18. Epub 2020 Jun 18.

Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Background: Colostrum is rich in microbiota. However, the quantity of microorganisms including both opportunistic pathogens and commensal mammary microbiota remains fluctuant during lactation. And once dysbiosis occurred in these microorganisms, a process in which the population of opportunistic pathogens increases while other bacteria, commensal mammary microbiota decrease. Read More

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http://dx.doi.org/10.21037/apm-20-56DOI Listing

Anlotinib or platinum-pemetrexed as second-line therapy in EGFR T790M-negative lung cancer.

Ann Palliat Med 2020 Jun 15. Epub 2020 Jun 15.

Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.

Background: Clinical management of T790M-negative patients after first-line epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) treatment failure is controversial. Anlotinib is a novel multi-target TKI for tumor angiogenesis and tumor cell proliferation, and it has been approved as a thirdline or beyond treatment for advanced non-small cell lung cancer (NSCLC). The impact of anlotinib as a second-line therapy compared with platinum-pemetrexed chemotherapy in T790M-negative patients after first-line EGFR-TKIs failed remains unclear. Read More

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http://dx.doi.org/10.21037/apm-20-105DOI Listing

Overview of voluntarily stopping eating and drinking to hasten death.

Ann Palliat Med 2020 Jun 10. Epub 2020 Jun 10.

Lancaster University, Lancaster LA1 4YG, UK.

Voluntarily stopping eating and drinking is a means of hastening death. Unlike euthanasia or medical aid in dying, which are available only in certain jurisdictions and with assistance from health care professionals, the ability to die by voluntarily stopping eating and drinking is determined by ongoing patient choice, although clinical and caregiver support is recommended. Few studies have examined the incidence of patients choosing to stop eating and drinking; studies in the Netherlands and United States suggest patients choosing this route have concerns about both physical and existential suffering. Read More

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http://dx.doi.org/10.21037/apm-19-525DOI Listing

Perceptions of physicians and nurses concerning advanced care planning for patients with heart failure in Japan.

Ann Palliat Med 2020 Jun 15. Epub 2020 Jun 15.

Department of Adult Nursing, Nursing Course, School of Medicine, Yokohama City University, Kanagawa, Japan.

Background: The importance of advance care planning (ACP) has been recognized in the palliative care of patients with heart failure. It is necessary for dissemination of ACP to characterize the perceptions of physicians and nurses towards ACP and to promote mutual understanding. The aim of this study is to investigate the perceptions of physicians and nurses concerning ACP for patients with heart failure. Read More

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http://dx.doi.org/10.21037/apm-19-685DOI Listing

Immunotherapy-related skeletal muscle weakness in cancer patients: a case series.

Ann Palliat Med 2020 Jun 21. Epub 2020 Jun 21.

Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Immunotherapy has become a lifeline in cancer treatment. However, increasingly reports of programmed death-1 (PD-1) inhibitors have been linked to autoimmune disorders. We highlight two unique cases that presented with skeletal weakness and resulted in fatalities after developing de novo myasthenia gravis and myositis associated to immunotherapy treatment. Read More

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http://dx.doi.org/10.21037/apm-20-454DOI Listing

Moral agency and spirituality in palliative care.

Ann Palliat Med 2020 Jun 14. Epub 2020 Jun 14.

Faculty of Medicine of the University of Porto, Porto, Portugal.

Moral agency is a prerequisite for a full autonomous decision, meaning that the agents have the intrinsic capacity to understand their actions and to be accountable for the consequences of these actions. Palliative care patients have the moral right to build their capacity to decide, so that they are truly empowered to make choices. However, moral and spiritual distress are common at the end-of-life, which may arise if there is a threat to the individual's integrity and disruption of one's belief system, consequently leading to the deterioration of the patient's moral agency. Read More

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http://dx.doi.org/10.21037/apm-19-436DOI Listing

Betulinic acid enhanced the chemical sensitivity of esophageal cancer cells to cisplatin by inducing cell pyroptosis and reducing cell stemness.

Ann Palliat Med 2020 Jun 15. Epub 2020 Jun 15.

Department of Pathology, Henan Medical College, Zhengzhou, China.

Background: Betulinic acid (BA) is a lupine pentacyclic triterpene compound derived from the bark of the white mulberry tree, which has a variety of pharmacological properties. The purpose of this study was to investigate the effects of BA combined with cisplatin on the proliferation, stemness, pyroptosis, and xenograft growth of esophageal carcinoma cells in a nude mouse xenograft model.

Methods: The cell survival rate was detected by CCK-8 method. Read More

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http://dx.doi.org/10.21037/apm-20-867DOI Listing

Immunotherapy for the management of cancer pain Fumimasa Amaya.

Authors:
Fumimasa Amaya

Ann Palliat Med 2020 Jun 10. Epub 2020 Jun 10.

Department of Pain Management and Palliative Care Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.21037/apm-20-959DOI Listing

Sophocarpine prevents cigarette smoke-induced restenosis in rat carotid arteries after angioplasty.

Ann Palliat Med 2020 Jun 9. Epub 2020 Jun 9.

Department of Vascular Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Background: Cigarette smoking is one of the main predisposing factors for atherosclerosis, which can lead to vascular inflammation. Emerging research has demonstrated that the rate of restenosis is increased following angioplasty in smokers. Sophocarpine, one of the Sophora alkaloids, can play the antiinflammatory role in cells. Read More

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http://dx.doi.org/10.21037/apm-19-568DOI Listing

Large pulmonary cavity in COVID-19 cured patient case report.

Ann Palliat Med 2020 Jun 9. Epub 2020 Jun 9.

Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), Kunming, China.

Coronavirus Disease 2019 (COVID-19) is a pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The outbreak began in Wuhan, China, and spread rapidly, with many cases confirmed in multiple countries. Usually, after viral pneumonia were clinical cured, the pulmonary lesions of majority patients will gradually be absorbed to complete dissipation, very few severe patients may retain pulmonary interstitial inflammation and fibrosis (1-3). Read More

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http://dx.doi.org/10.21037/apm-20-452DOI Listing

Association between vitamin D deficiency and fragility fractures in Chinese elderly patients: a cross-sectional study.

Ann Palliat Med 2020 Jun 5. Epub 2020 Jun 5.

Department of Geriatrics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Vitamin D deficiency can lead to osteoporosis and increases the risk of fractures. Vitamin D deficiency is prevalent in Asian populations, however, research focusing on the association between vitamin D deficiency and osteoporotic hip fractures, particularly in Chinese populations is scarce. The aim of this study was to explore the relationship between vitamin D deficiency and osteoporotic hip fractures in elderly Chinese patients. Read More

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http://dx.doi.org/10.21037/apm-19-610DOI Listing

Effect on survival of local treatment in patients with low prostate-specific antigen, high Gleason score prostate cancer: a population-based propensity score-matched analysis.

Ann Palliat Med 2020 May 30. Epub 2020 May 30.

Department of Urology, Subei People's Hospital of Jiangsu Province (Clinical Medical College, Yangzhou University), Yangzhou, China.

Background: Emerging data suggest that in patients with low prostate-specific antigen (PSA) and high Gleason score, prostate cancer (PCa) is more aggressive and more likely to be related to genomic characteristics of neuroendocrinology. However, the evidence for the advantages of local treatment (LT) for these men is lacking. Hence, we investigated survival in men with low-PSA values and high-grade (Gleason score 8-10) PCa according to the treatment of the primary tumor. Read More

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http://dx.doi.org/10.21037/apm-19-414DOI Listing

The role of peripheral brain-derived neurotrophic factor in chronic osteoarthritic joint pain.

Ann Palliat Med 2020 May 22. Epub 2020 May 22.

Departments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University School of Medicine, Shreveport, LA, USA.

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http://dx.doi.org/10.21037/apm-20-888DOI Listing

Adverse early life experiences are associated with changes in pressure and cold pain sensitivity in young adults.

Ann Palliat Med 2020 Jun 3. Epub 2020 Jun 3.

Physiology, School of Medicine, Galway Neuroscience Centre and Centre for Pain Research, National University of Ireland Galway, Ireland.

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http://dx.doi.org/10.21037/apm-20-914DOI Listing

Relationship between glucagon-like peptide-1 receptor gene polymorphism and bone mineral density in postmenopausal women in Shanghai.

Ann Palliat Med 2020 Jun 8. Epub 2020 Jun 8.

Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are able to inhibit bone resorption to a certain extent and improve bone formation. GLP-1R single nucleotide polymorphism (SNP) is related to its activity, but the relationship between GLP-1R SNP and osteoporosis in postmenopausal women was still unclear. This study was to investigate the association between GLP-1R SNP and bone mineral density (BMD) in postmenopausal women in Shanghai. Read More

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http://dx.doi.org/10.21037/apm-19-396DOI Listing

Medically inoperable Merkel cell carcinoma of the head and neck treated with stereotactic body radiation therapy: a case report.

Ann Palliat Med 2020 Jun 2. Epub 2020 Jun 2.

Department of Oncology, Juravinski Cancer Centre, McMaster University, Ontario, Canada.

Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine tumour of the skin. MCC is the second most common cause of death from non-melanoma skin cancer and the most aggressive cutaneous malignancy. An 88-year-old male presented with a large, bleeding skin tumour located on the right temple and pre-auricular region. Read More

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http://dx.doi.org/10.21037/apm-20-258DOI Listing

Glans metastatic extra-nodal natural killer/T-cell lymphoma, nasal-type with HDAC inhibitor as maintenance therapy: a rare case report with literature review.

Ann Palliat Med 2020 May 27. Epub 2020 May 27.

Department of Oncology, West China Hospital, Sichuan University, Chengdu, China.

Extra-nodal natural killer/T-cell lymphoma (ENKTL) is an aggressive lymphoid malignancy and advanced ENKTL is characterized by a dismal survival outcome. Distant metastasis is frequently common in advanced ENKTLs, while the glans is rarely involved. Here we report a 67-year-old Chinese male with glans metastasis ENKTL, nasal type secondary from the nasal cavity, treated with modified SMILE regimen plus glans radiotherapy and achieved a complete remission (CR). Read More

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http://dx.doi.org/10.21037/apm-19-430bDOI Listing

Association of systolic blood pressure with atrial fibrillation among treated hypertensive patients.

Ann Palliat Med 2020 Jun 4. Epub 2020 Jun 4.

Department of Cardiology, Hypertension Research Laboratory, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

Background: Although many studies have suggested the association between elevated blood pressure and atrial fibrillation (AF), how the relationship between systolic blood pressure (SBP) and AF differ by antihypertensive treatment has been unclear. Therefore, this study aimed to explore the relationship between SBP and AF in hypertensive patients with or without antihypertensive treatment.

Methods: This was a cross-sectional study that enrolled 7,808 hypertensive patients aged ≥18 years old in 2013 in Guangdong, China. Read More

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http://dx.doi.org/10.21037/apm-19-649DOI Listing

Prolonged endotracheal intubation: a feasible option for tracheomalacia after retrosternal goitre surgery.

Ann Palliat Med 2020 May 25. Epub 2020 May 25.

Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, China.

Background: Tracheomalacia may be caused by long-standing compression of retrosternal goitre because of destruction of support of tracheal cartilages. Life-threatening airway collapses may occur after surgical removal of goitre. However, available literature on management methods of tracheomalacia is sparse. Read More

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http://dx.doi.org/10.21037/apm-19-552DOI Listing

The efficacy and safety comparison of PD-1/PD-L1 antibody, chemotherapy and supportive treatment for pretreated advanced esophagogastric cancer: a network meta-analysis.

Ann Palliat Med 2020 Jun 4. Epub 2020 Jun 4.

Department of Gastroenterology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Marshall B.J. Medical Research Center of Zhengzhou University, Zhengzhou, China.

Background: Immunotherapy is important for the treatment of esophagogastric cancer. The purpose of this study is to compare the efficacy and safety of PD-(L)1 antibody, chemotherapy, and supportive treatment in the management of pretreated advanced esophagogastric cancer.

Methods: The randomized controlled trials were identified by searching electronic databases including PubMed, Cochrane Library and Embase database. Read More

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http://dx.doi.org/10.21037/apm-19-670DOI Listing

Colchicine poisoning complicated by medulla oblongata myelinolysis: a case report.

Ann Palliat Med 2020 May 25. Epub 2020 May 25.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

Medulla oblongata myelinolysis is an extremely rare manifestation of extrapontine myelinolysis (EPM). Herein, we report a case of a 34-year-old man with a history of gout who presented repeated vomiting and diarrhea after ingesting 15 colchicine pills. A hyponatremia diagnosis was given and after an intensive treatment, his serum sodium level increased from 118 to 129 mmol/L within 24 hours. Read More

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http://dx.doi.org/10.21037/apm-19-627DOI Listing

Effect of alectinib versus crizotinib on progression-free survival, central nervous system efficacy and adverse events in ALK- positive non-small cell lung cancer: a systematic review and meta-analysis.

Ann Palliat Med 2020 Jun 8. Epub 2020 Jun 8.

Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing, China.

Background: Lung cancer is the most common malignant tumor, and it remains the major cause of cancerrelated death worldwide. Anaplastic lymphoma kinase fusion gene-rearrangement (ALK-positive) nonsmall cell lung cancer (NSCLC) is a unique subgroup that accounts for 3-7% of NSCLC cases. Over the last few years, the introduction of several ALK inhibitors has completely altered the treatment of advanced ALK-positive NSCLC and significantly improved the prognosis for patients. Read More

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http://dx.doi.org/10.21037/apm-19-643DOI Listing

Image-guided hypofractionated simultaneous integrated boost and adaptive radiotherapy for spine metastasis.

Ann Palliat Med 2020 Jun 5. Epub 2020 Jun 5.

The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China.

Background: (I) Dosimetric comparison between Helical tomotherapy (HT) and intensity-modulated radiation therapy (IMRT) with hypofractionated simultaneously integrated boost (HF-SIB) technique for spine metastasis. (II) Mega-voltage CT (MVCT) imaging can be used to monitor changes and calculate the true spinal cord dose over multiple fractions, and compare it with the planned dose by deformable image registration.

Methods: We retrospectively analyzed 57 patients with spine metastasis receiving HT at our institution between March 2016 and March 2019. Read More

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http://dx.doi.org/10.21037/apm-20-13DOI Listing

Fat-poor renal angiomyolipoma combined with pseudoaneurysm: a case report.

Ann Palliat Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Abdominal Ultrasound, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.

Renal angiomyolipoma (RAML), a rare benign mesenchymal tumor, consists of variable proportions of thick-walled blood vessels admixed with adipose tissue and bundles of smooth muscle. Rarely, RAML angiomyolipoma may be associated with pseudoaneurysm, spontaneous rupture and hemorrhage. we herein present an exceptional case of fat-poor RAML containing a large pseudoaneurysm in a 48-yearold woman with known pulmonary lymphangioleiomyomatosis (PLAM), who was admitted to hospital due to right flank pain for about two months. Read More

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http://dx.doi.org/10.21037/apm-20-475DOI Listing

De-escalation of neoadjuvant therapy for HER2-positive early breast cancer: an overview.

Ann Palliat Med 2020 May 25. Epub 2020 May 25.

Latin American Cooperative Oncology Group, Porto Alegre, Brazil.

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http://dx.doi.org/10.21037/apm-20-1035DOI Listing

Using medical comics to explore challenging everyday topics in medicine: lessons learned from teaching medical humanities.

Ann Palliat Med 2020 May 27. Epub 2020 May 27.

Teaching Center, Medical University of Vienna, Vienna, Austria.

Background: Studying medicine requires an extensive acquisition of knowledge, skills and attitudes. At the MedUni Vienna, this wide range of skills is strengthened by discussing aspects of medical humanities (MH) with medical students in their pre-clinical fifth study year. Medical comics (MCs), as a part of MH, offer the possibility to address challenging situations within medical settings through the use of graphic illustrations. Read More

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http://dx.doi.org/10.21037/apm-20-261DOI Listing

Considering self-reported baseline function and cognition in predicting post-operative complications among older adults.

Ann Palliat Med 2020 May 22. Epub 2020 May 22.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Background: Older adults experience high rates of postoperative complications and poorer outcomes. Current perioperative risk assessments lack specific measures and are too time-consuming for busy surgeons.

Methods: Using data from the Health and Retirement Study Survey linked with Medicare data, we performed a cross-sectional study, evaluating all adults ≥65 years old who underwent high-risk elective surgery between 1992-2012. Read More

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http://dx.doi.org/10.21037/apm-20-816DOI Listing

C4 radiculopathy misdiagnosed as myofascial pain syndrome in the upper trapezius.

Ann Palliat Med 2020 05;9(3):1275-1277

Department of Physical Medicine and Rehabilitation, Centre hospitalier de l'Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.21037/apm.2020.04.11DOI Listing

Antibiotic susceptibility and molecular analyses of clinical Enterobacter cloacae isolates in Eastern Heilongjiang Province, China.

Ann Palliat Med 2020 May;9(3):1211-1219

Department of Microbiology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China; Department of Microbiology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China.

Background: Enterobacter cloacae is an emerging opportunistic pathogen. We retrospectively conducted a study to assess antimicrobial susceptibility and investigated the Molecular characteristics of carbapenem-resistant Enterobacter cloacae (CREL) isolates.

Methods: Three hundred forty-two isolates of Enterobacter cloacae were collected from January 2014 to December 2018. Read More

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http://dx.doi.org/10.21037/apm-20-1089DOI Listing

Endoscopic incision and selective cutting for primary treatment of benign esophageal anastomotic stricture: outcomes of 5 cases with a minimum follow-up of 12 months.

Ann Palliat Med 2020 May;9(3):1206-1210

Gastroenterology and Center of Digestive Endoscopy, the Second Hospital of Jilin University, Changchun 130041, China.

Background: Benign anastomotic esophageal stricture after surgical resection frequently occurs and requires endoscopic balloon dilation (EBD) or incision to maintain patency because of the significant recurrence rate. Our study was designed to evaluate the effectiveness and safety of endoscopic incision and selective cutting (EISC) as primary treatment on 5 patients for benign anastomotic esophageal stricture.

Methods: Five patients with benign stricture of the esophageal anastomosis after radical resection for esophageal cancer underwent EISC in our center between April, 2018 and January, 2019. Read More

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http://dx.doi.org/10.21037/apm-20-1090DOI Listing

Application of the PDCA cycle for standardized nursing management in a COVID-19 intensive care unit.

Ann Palliat Med 2020 May;9(3):1198-1205

Department of Nursing, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Background: Nursing quality is an integral part of health care quality and one of key performance indicators (KPIs) for health care management. The Plan-Do-Check-Act (PDCA) cycle is a management tool for continuous improvement of a business's products or processes. It can be applied to standardize nursing management and thus improve the nursing quality and increase the survival rate of patients. Read More

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http://dx.doi.org/10.21037/apm-20-1084DOI Listing

3D-STI evaluation of the effect of dexrazoxane on the mechanical properties of right ventricular myocardium in breast cancer patients treated with pirarubicin.

Ann Palliat Med 2020 May;9(3):1187-1197

Department of Medical Ultrasonography, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.

Background: Observation indexes used to evaluate the effect of dexrazoxane-anthracycline combinations in breast cancer often only take into account the clinical symptoms, or left ventricular ejection fraction (LVEF), biomarkers [such as creatine kinase MB (CK-MB), brain natriuretic peptide (BNP) and cardiac troponin T (cTnT)], or tumor recurrence rate, improvement of autonomic nerve function or economic benefits. This study aimed to evaluate the effect of dexrazoxane on the changes of mechanical properties of right ventricular myocardium in patients who underwent pirarubicin chemotherapy with three-dimensional speckle-tracking imaging (3D-STI).

Methods: A total of 64 breast cancer post-operation patients who received pirarubicin chemotherapy were randomly divided into two groups: the experimental group (with dexrazoxane added) and the control group (without dexrazoxane). Read More

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http://dx.doi.org/10.21037/apm-20-1074DOI Listing

Acupuncture inhibits the activation of spinal microglia in the acute uterine cervical distension rats.

Ann Palliat Med 2020 May;9(3):1180-1186

Department of Anesthesia, the Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Background: Although labor pain is treated clinically by the administration of local anesthetics alone or with opioids in the epidural or spinal spaces, however, the mechanisms of labor pain mechanisms have not been fully elucidated during to the lack of animal models, and the side effects of drugs still existed. Spinal microglia can be activated or mobilized under several pain states, and we want to explore the activation of spinal microglia is involved in the acute uterine cervical distension rats or not.

Methods: (I) The electromyographic (EMG) response to uterine cervical distension (UCD) was observed. Read More

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http://dx.doi.org/10.21037/apm-20-693DOI Listing

Clinical effect of Rougan Tongdu combined with point-pressing massage therapy on children at high risk of delayed motor development.

Ann Palliat Med 2020 May;9(3):1174-1179

Department of Pediatrics, The First Affiliated Hospital of Guizhou University of Chinese Traditional Medicine, Guiyang, China.

Background: Delayed motor development (DMD) is an extremely common development disorder in children. Multiple factors, including mother's influence, diseases, physical or chemical factors and trauma, are strongly associated with DMD. Infancy is a key period in the development of neuromotor function. Read More

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http://dx.doi.org/10.21037/apm-20-1057DOI Listing