2,746 results match your criteria Annals of nuclear medicine[Journal]


Detectable size of melanoma metastases to brain on PET/CT.

Ann Nucl Med 2020 May 25. Epub 2020 May 25.

UNC Department of Radiology, Chapel Hill Hospitals, 101 Manning Drive, Chapel Hill, NC, 27514, USA.

Objective: We aimed to determine at what size melanoma metastases become detectable by PET/CT.

Methods: We reviewed a total of 293 whole-body PET/CT studies performed on 212 patients for staging of melanoma where there was an MRI within a month of the PET/CT. MR and PET/CT were reviewed independently by separate readers. Read More

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http://dx.doi.org/10.1007/s12149-020-01481-8DOI Listing

Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang's method.

Ann Nucl Med 2020 May 24. Epub 2020 May 24.

Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-0022, Japan.

Objective: We examined the diagnostic value of brain perfusion single-photon emission computed tomography (SPECT) using voxel-based statistical analysis with CT-based attenuation correction (CT-AC) by comparing it to that with Chang's AC in mild cognitive impairment (MCI) patients and attempted to locate brain areas that are good indicators predicting the progression of MCI.

Methods: Twenty-six individuals matched for age, educational background and initial Mini-Mental State Examination (MMSE) score of more than 24 underwent SPECT with N-isopropyl-4-[I]iodoamphetamine and were assigned to 2 groups: the stable MCI (S-MCI) group comprising 11 subjects who maintained their MMSE score (mean 27.0) during at least a 1-year follow-up period (mean 37. Read More

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http://dx.doi.org/10.1007/s12149-020-01477-4DOI Listing

Applying Wells score to inconclusive perfusion only modified PIOPED II (Prospective Investigation of Pulmonary Embolism Diagnosis II) readings in order to optimize the lung scintigraphy diagnostic yield in acute pulmonary embolism detection.

Ann Nucl Med 2020 May 23. Epub 2020 May 23.

School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: When using perfusion only modified PIOPED II criteria for PE detection, generated non-diagnostic scans are found to be the main diagnostic restriction. The objective of current study is to identify the role of Wells criteria added to inconclusive readings with the intent of enhancing the lung scintigraphy diagnostic yield.

Methods: CTPA was performed in 34 suspected PE patients with inconclusive lung scintigraphy. Read More

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http://dx.doi.org/10.1007/s12149-020-01478-3DOI Listing

Preoperative F-18 fluorocholine PET/CT for the detection of hyperfunctioning parathyroid glands in patients with secondary or tertiary hyperparathyroidism: comparison with Tc-99m sestamibi scan and neck ultrasound.

Ann Nucl Med 2020 May 20. Epub 2020 May 20.

Department of Nuclear Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Objectives: Currently, neck ultrasound is the preferred preoperative imaging in patients with secondary/tertiary hyperparathyroidism, and the use of Tc-99m sestamibi scan is limited in these patients. We conducted this study to compare the diagnostic utilities of F-18 fluorocholine PET/CT, Tc-99m sestamibi scintigraphy, and neck ultrasound for localizing hyperfunctioning parathyroid glands in secondary/tertiary hyperparathyroidism.

Methods: We prospectively enrolled 30 dialysis patients with a diagnosis of secondary/tertiary hyperparathyroidism; of these, 27 participants underwent all three imaging modalities, including dual-phase F-18 fluorocholine PET/CT (PET acquired 5 and 60 min after tracer injection), dual-phase Tc-99 m sestamibi SPECT/CT, and neck ultrasound. Read More

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http://dx.doi.org/10.1007/s12149-020-01479-2DOI Listing

Physiological 18F-FDG uptake in the normal adult anal canal: evaluation by PET/CT.

Ann Nucl Med 2020 May 19. Epub 2020 May 19.

Faculty of Medicine, Oita University, Yufu, Oita, Japan.

Objective: Despite their benefit for detecting primary tumors, data for normal F-fluoro-2-deoxy-D-glucose (FDG) uptake in the anal canal are insufficient. Here we used positron emission tomography-computed tomography (PET/CT) to determine the uptake of FDG in the normal adult anal canal (AC) and to evaluate its clinical significance compared with that of anal cancer.

Methods: We conducted a retrospective study of-PET/CT images in the anal region, of 201 consecutive patients without symptoms or pathology taken from January 2015 to August 2019, after excluding two patients (one each with Crohn's disease and hemorrhoid). Read More

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http://dx.doi.org/10.1007/s12149-020-01480-9DOI Listing

Effects of animal handling on striatal DAT availability in rats.

Ann Nucl Med 2020 May 18. Epub 2020 May 18.

Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea.

Objective: Positron emission tomography (PET) is a non-invasive technique measuring quantification of physiological and biochemical processes in the living organism. However, there are many considerations including anesthesia and fasting to acquire small animal imaging. We aimed to evaluate the effects of anesthesia and fasting of rats in dopamine transporter (DAT) imaging acquisition. Read More

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http://dx.doi.org/10.1007/s12149-020-01476-5DOI Listing

Does bone scintigraphy still have a role in the era of 68 Ga-PSMA PET/CT in prostate cancer?

Ann Nucl Med 2020 May 11. Epub 2020 May 11.

Department of Nuclear Medicine, Istanbul University, Istanbul Faculty of Medicine, 34093, Fatih, İstanbul, Turkey.

Objection: We aimed to evaluate the role of bone scintigraphy (BS) which has long been the imaging modality of choice in prostate cancer (PCa) and performed a head-to-head comparison between BS, BS + SPECT/CT and 68 Ga-PSMA-PET/CT, for the detection of bone metastasis of PCa.

Methods: We evaluated 138 PCa patients who underwent BS and 68 Ga-PSMA PET/CT and SPECT/CT of 102 of 138 patients. Images were interpreted retrospectively and areas of abnormally increased tracer uptake related to PCa were documented as benign, metastatic or equivocal. Read More

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http://dx.doi.org/10.1007/s12149-020-01474-7DOI Listing

In vitro/in vivo assessment of the targeting ability of [Tc] Tc-labeled an aptide specific to the extra domain B of fibronectin (APT) for colorectal cancer.

Ann Nucl Med 2020 May 10. Epub 2020 May 10.

Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, 48471-93698, Sari, Mazandaran, Iran.

Objective: The APT is an aptide specific to the extra domain B (EDB) of fibronectin with high affinity for EDB, which is expressed in malignant tumors including brain cancer (U87MG) and colorectal cancer (HT-29). Aim of this study was to evaluate the [Tc] Tc-APT potential as an imaging probe for colorectal cancer.

Methods: Radiochemical purity was evaluated by HPLC and radio-isotope TLC scanner. Read More

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http://dx.doi.org/10.1007/s12149-020-01472-9DOI Listing

Synthesis and evaluation of novel radioiodinated anthranilate derivatives for in vivo imaging of vascular endothelial growth factor receptor with single-photon emission computed tomography.

Ann Nucl Med 2020 May 8. Epub 2020 May 8.

Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.

Objective: Angiogenesis facilitates tumor survival and promotes malignancy. The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) tyrosine kinase (TK) signaling pathway is a key factor mediating angiogenesis, suggesting that this pathway may be a target for diagnosis and therapy. In this study, we aimed to develop small molecule radioiodinated probes applicable for in vivo VEGFR imaging considering the versatility and usefulness of single-photon emission computed tomography (SPECT). Read More

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http://dx.doi.org/10.1007/s12149-020-01475-6DOI Listing

Improvement in cognitive decline after indirect bypass surgery in adult moyamoya disease: implication of O-gas positron emission tomography.

Ann Nucl Med 2020 May 6. Epub 2020 May 6.

Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Purpose: To investigate the characteristics of patients with moyamoya disease (MMD) who show improvement in their cognitive decline after bypass surgery by analyzing the hemodynamic and metabolic parameters of O-gas positron emission tomography (PET).

Materials And Methods: We retrospectively analyzed adult patients with MMD who were evaluated with PET and cognitive tests before and approximately one year after indirect bypass surgery. The PET parameters of the left Rolandic area were compared between patients who did and did not show improvement in their cognitive decline. Read More

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http://dx.doi.org/10.1007/s12149-020-01473-8DOI Listing

Methods for analyzing binary of data clusters into intestinal segments of the patients.

Ann Nucl Med 2020 May 2. Epub 2020 May 2.

Nuclear Medicine Department, Hospital de Base Do Distrito Federal, Brasília, Brazil.

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http://dx.doi.org/10.1007/s12149-020-01471-wDOI Listing

Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [I]IIMU, in healthy volunteers.

Ann Nucl Med 2020 May 2. Epub 2020 May 2.

Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.

Objective: We evaluated the radiation dosage, biodistribution, human safety, and tolerability of the injection of a single dose of [I] 5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracil (IIMU), a new radiotracer targeting thymidine phosphorylase (TP), in healthy volunteers.

Methods: Potential participants were tested at our hospital to confirm their eligibility. Two healthy male adults passed the screening tests. Read More

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http://dx.doi.org/10.1007/s12149-020-01469-4DOI Listing

Oral Gallium Citrate Scintigraphy in assessment of inflammatory activity of Crohn's disease: methodological issues on accuracy and agreement.

Authors:
Siamak Sabour

Ann Nucl Med 2020 Apr 30. Epub 2020 Apr 30.

Department of Clinical Epidemiology, School of Health and Safety, Shahid Beheshti University of Medical Sciences, Chamran Highway, Velenjak, Daneshjoo Blvd, Tehran, 198353-5511, Islamic Republic of Iran.

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http://dx.doi.org/10.1007/s12149-020-01470-xDOI Listing

An impact of microscopic positive margin on incomplete response after I-131 treatment in differentiated thyroid cancer.

Ann Nucl Med 2020 Apr 22. Epub 2020 Apr 22.

Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objective: To find an impact of microscopic positive margin on incomplete response after initial I-131 therapy in differentiated thyroid cancer.

Methods: We retrospectively recruited patients with differentiated thyroid cancer who underwent total thyroidectomy and received the first dose of radioiodine during January 2014-February 2018. Patients with grossly incomplete tumor resection or distant metastasis at the time of radioiodine therapy were excluded. Read More

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http://dx.doi.org/10.1007/s12149-020-01467-6DOI Listing

AI approach of cycle-consistent generative adversarial networks to synthesize PET images to train computer-aided diagnosis algorithm for dementia.

Ann Nucl Med 2020 Apr 20. Epub 2020 Apr 20.

Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University, Osaka, Japan.

Objective: An artificial intelligence (AI)-based algorithm typically requires a considerable amount of training data; however, few training images are available for dementia with Lewy bodies and frontotemporal lobar degeneration. Therefore, this study aims to present the potential of cycle-consistent generative adversarial networks (CycleGAN) to obtain enough number of training images for AI-based computer-aided diagnosis (CAD) algorithms for diagnosing dementia.

Methods: We trained CycleGAN using 43 amyloid-negative and 45 positive images in slice-by-slice. Read More

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http://dx.doi.org/10.1007/s12149-020-01468-5DOI Listing

Assessment of lung glucose uptake in patients with systemic lupus erythematosus pulmonary arterial hypertension: a quantitative FDG-PET imaging study.

Ann Nucl Med 2020 Jun 20;34(6):407-414. Epub 2020 Apr 20.

Department of Medicine, Hammersmith Hospital, Center for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, Du Cane Road, London, W12 ONN, UK.

Purpose: Pulmonary arterial hypertension (PAH) is a recognized complication of systemic lupus erythematosus (SLE-PAH) patients and its lung pathology shares similarity to idiopathic PAH (IPAH) with distinctive inflammatory feature. FDG-PET reports glucose metabolism from both hyperproliferative and inflammatory cellular elements of vascular pathology in PAH. We explored the application of FDG-PET in reporting SLE-PAH pulmonary vascular pathology. Read More

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http://dx.doi.org/10.1007/s12149-020-01461-yDOI Listing
June 2020
1.507 Impact Factor

A diagnostic strategy for Lewy body disease using DAT-SPECT, MIBG and Combined index.

Ann Nucl Med 2020 Jun 16;34(6):415-423. Epub 2020 Apr 16.

Department of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Kumamoto, Kumamoto, 8608550, Japan.

Purpose: The functional imaging methods widely used for the diagnosis of Lewy body disease (LBD) are I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropan (FP-CIT) with dopamine transporter single photon emission computed tomography (DAT-SPECT) and I-iodobenzylguanidine (MIBG) myocardial scintigraphy. The aim of this study was to determine whether DAT-SPECT or I-MIBG myocardial scintigraphy should be examined first and to evaluate whether the combined use of DAT-SPECT and MIBG myocardial scintigraphy is superior to using either modality alone for diagnosing suspected LBD.

Methods: In this retrospective study, a total of 117 patients suspected of having LBD underwent DAT-SPECT imaging followed by MIBG myocardial scintigraphy. Read More

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http://dx.doi.org/10.1007/s12149-020-01464-9DOI Listing

Prognostic value of pretreatment tumor-to-blood standardized uptake ratio (SUR) in rectal cancer.

Ann Nucl Med 2020 Jun 15;34(6):432-440. Epub 2020 Apr 15.

Department of Nuclear Medicine, Uludag University School of Medicine, 16059, Bursa, Turkey.

Objectives: The prognostic value of SUV on pretreatment F-18 FDG PET/CT imaging in patients with rectal cancer is a matter of debate. SUR is of prognostic value for survival in different cancers. In this study, we aimed to examine the potential prognostic value of SUR and other parameters in pretreatment F-18 FDG PET/CT for non-metastatic rectal cancer. Read More

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http://dx.doi.org/10.1007/s12149-020-01465-8DOI Listing

Radiation exposure in nurses during care of I-MIBG therapy for pediatric patients with high-risk neuroblastoma.

Ann Nucl Med 2020 Jun 15;34(6):441-447. Epub 2020 Apr 15.

Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Objective: I-meta-iodo-benzyl-guanidine (I-MIBG) therapy has been used in children with high-risk neuroblastoma, who, in Japan, are cared for by trained nurses. To determine the safety of occupational radiation exposure in nurses, we retrospectively examined radiation exposure during therapy.

Methods: Sixty-two nurses who received radiation exposure during I-MIBG therapy were assessed for the daily percentage of total radiation exposure received using the formula, daily radiation exposure/total radiation dose × 100; self-care score of children was evaluated. Read More

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http://dx.doi.org/10.1007/s12149-020-01466-7DOI Listing

Assessing the feasibility of NaF-PET/CT versus FDG-PET/CT to detect abdominal aortic calcification or inflammation in rheumatoid arthritis patients.

Ann Nucl Med 2020 Jun 10;34(6):424-431. Epub 2020 Apr 10.

Department of Radiology, Hospital of University of Pennsylvania, 3400 Spruce St, Philadelphia, PA, 19104, USA.

Objective: We aimed to determine whether NaF-PET/CT or FDG-PET/CT can detect abdominal aortic molecular calcification and inflammation in patients with rheumatoid arthritis (RA).

Methods: In this study, 18 RA patients (4 women, 14 men; mean age 56.0 ± 11. Read More

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http://dx.doi.org/10.1007/s12149-020-01463-wDOI Listing

Standardized thresholds of volume-based PET/CT parameters predicting survival of patients with pancreatic head cancer treated with stereotactic body radiation therapy.

Ann Nucl Med 2020 Jun 10;34(6):379-387. Epub 2020 Apr 10.

Departments of Nuclear Medicine, Changhai Hospital Affiliated to the Second Military Medical University, Changhai Road 168, Yangpu District, Shanghai, 200433, People's Republic of China.

Objective: To explore standardized relative thresholds of volume-based parameters on FDG PET/CT, and define the optimal prognosticator among the relative thresholds for patients with locally advanced pancreatic head cancer (LAPHC) treated by stereotactic body radiation therapy (SBRT).

Methods: Thirty-five patients with LAPHC were enrolled, and all underwent SBRT and baseline FDG PET/CT scan. Maximum standardized uptake value (SUVmax) was measured, and metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated under the relative (30%, 40%, and 50%) thresholds of SUVmax. Read More

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http://dx.doi.org/10.1007/s12149-020-01454-xDOI Listing

Retrospective correlation of ga-psma uptake with clinical parameters in prostate cancer patients undergoing definitive radiotherapy.

Ann Nucl Med 2020 Jun 27;34(6):388-396. Epub 2020 Mar 27.

Faculty of Medicine, Department of Nuclear Medicine, Adana Dr Turgut Noyan Research and Treatment Center, Başkent University, Adana, Turkey.

Objective: The aim of the study is to investigate the correlation between the intensity of prostate-specific membrane antigen (PSMA) uptake in primary tumor and clinico-pathological characteristics of non-metastatic prostate cancer patients treated with definitive radiotherapy (RT).

Methods: Using the clinical data of 201 prostate cancer patients who were referred for  Ga-PSMA-positron emission tomography (PET/CT) for staging and RT planning, we analyzed the correlations among intermediate- or high-risk disease based on Gleason score (GS), prostate-specific antigen (PSA) level, D'Amico risk group classification, and maximum standardized uptake (SUV) of primary tumor.

Results: Primary tumor was visualized via  Ga-PSMA-PET/CT scan in 192 patients (95. Read More

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http://dx.doi.org/10.1007/s12149-020-01462-xDOI Listing

High-dose I-metaiodobenzylguanidine therapy in patients with high-risk neuroblastoma in Japan.

Ann Nucl Med 2020 Jun 26;34(6):397-406. Epub 2020 Mar 26.

Department of Nuclear Medicine, Kanazawa University Hospital and Department of Nuclear Medicine, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Objective: The aim of the study was to investigate the outcomes and prognostic factors of high-dose I-metaiodobenzylguanidine (I-MIBG) therapy in patients with refractory or relapsed neuroblastoma (NBL) in Japan.

Methods: We retrospectively analyzed 20 patients with refractory or relapsed high-risk NBL who underwent I-MIBG therapy with an administration dose ranging from 444 to 666 MBq/kg at Kanazawa University Hospital, Japan, between September 2008 and September 2013. We focused on measurements regarding their initial responses, prognostic factors, survivals, and toxicities following I-MIBG therapy using our hospital data and questionnaires from the hospitals that these patients were initially referred from. Read More

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http://dx.doi.org/10.1007/s12149-020-01460-zDOI Listing

Ten-year prospective evaluation of whole-body cancer screening with multiple modalities including [F]fluorodeoxyglucose positron emission tomography in a healthy population.

Ann Nucl Med 2020 May 21;34(5):358-368. Epub 2020 Mar 21.

Translational Research Center for Medical Innovation, Foundation for Biomedical Research and Innovation, 1-5-4 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Purpose: To prospectively evaluate the value of whole-body cancer screening with multiple modalities including FDG-PET in a healthy population.

Methods: The study was conducted in 1197 healthy individuals aged ≥ 35 years at enrollment between August 2003 and July 2004. All participants were scheduled to receive annual whole-body cancer screening five times (screening period) with subsequent long-term follow-up (follow-up period). Read More

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http://dx.doi.org/10.1007/s12149-020-01456-9DOI Listing

Pet tracers for vulnerable plaque imaging.

Ann Nucl Med 2020 May 20;34(5):305-313. Epub 2020 Mar 20.

Nuclear Medicine Laboratory, University of Thessaly, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece.

Most of the acute ischemic events, such as acute coronary syndromes and stroke, are attributed to vulnerable plaques. These lesions have common histological and pathophysiological features, including inflammatory cell infiltration, neo-angiogenesis, remodelling, haemorrhage predisposition, thin fibrous cap, large lipid core, and micro-calcifications. Early detection of the presence of a plaque prone to rupture could be life-saving for the patient; however, vulnerable plaques usually cause non-haemodynamically significant stenosis, and anatomical imaging techniques often underestimate, or may not even detect, these lesions. Read More

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http://dx.doi.org/10.1007/s12149-020-01458-7DOI Listing

Ciliated muconodular papillary tumor of the lung: 18F-FDG PET/CT findings of 15 cases.

Ann Nucl Med 2020 Jun 14;34(6):448-452. Epub 2020 Mar 14.

Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Objective: Ciliated muconodular papillary tumor (CMPT) is a rare lung tumor that was first reported in 2002. This study assessed 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings of CMPT of the lung.

Methods: FDG PET/CT findings of 15 patients (eight men and seven women; median age, 67 years) with surgically resected CMPTs were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s12149-020-01457-8DOI Listing

Feasibility of gamma camera-based GFR measurement using renal depth evaluated by lateral scan of Tc-DTPA renography.

Ann Nucl Med 2020 May 13;34(5):349-357. Epub 2020 Mar 13.

Advanced Clinical Research Center, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960-1295, Japan.

Objective: Gamma camera-based measurement of glomerular filtration rate (GFR) with Tc-diethylenetriaminepentaacetic acid (DTPA) is an established non-invasive measurement of split renal function; however, it is not as accurate as the plasma sample method. Therefore, study into improving the accuracy of such method is clinically relevant. The aim of this study was to elucidate the feasibility of gamma camera-based GFR measurement using renal depth evaluated by lateral scan of Tc-DTPA renography and comparing the results with those of GFR using renal depth measured by CT, and three representative formulas. Read More

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http://dx.doi.org/10.1007/s12149-020-01455-wDOI Listing

Relationships between amyloid levels, glucose metabolism, morphologic changes in the brain and clinical status of patients with Alzheimer's disease.

Ann Nucl Med 2020 May 9;34(5):337-348. Epub 2020 Mar 9.

Department of Radiology, Her Majesty's Cardiac Center, Division of Nuclear Medicine, Faculty of Medicine, Siriraj Hospital, Building Fl.12th, 2 Wanglang Road Bangkoknoi, Bangkok, 10700, Thailand.

Objective: The current study was conducted to improve the understanding of relationships between regional cortical amyloid load, glucose metabolism, cortical morphology (volume), and severity of clinical symptoms in patients with AD, MCI, and age-matched controls.

Methods: To objectivize the radiological evaluation of patients with suspected AD, head-to-head multi-modality imaging studies were conducted using MRI and PET/CT with [F]FDG and [F]AV45 for visualization and quantitation of brain morphology, glucose metabolism, and amyloid levels, respectively. A total of 84 subjects was studied, including 33 patients with AD, 31 patients with MCI, and 20 age-matched healthy controls (HC). Read More

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http://dx.doi.org/10.1007/s12149-020-01453-yDOI Listing

Diagnosis of bladder cancer using F-labeled α-methyl-phenylalanine tracers in a mouse model.

Ann Nucl Med 2020 May 6;34(5):329-336. Epub 2020 Mar 6.

Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, 371-8511, Japan.

Objective: Although 2-F-fluoro-2-deoxy-glucose (F-FDG) has established roles in the diagnosis of a variety of cancers, it has limited value in the detection of primary/recurrent lesions in the bladder, mainly because of interference by the pooled radioactivity in the urine. Our previous study revealed promising properties of L- and D-2-F-α-methyl-phenylalanine (2-F-FAMP) as radiotracers; i.e. Read More

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http://dx.doi.org/10.1007/s12149-020-01452-zDOI Listing

F-FDG maximum standard uptake value predicts PD-L1 expression on tumor cells or tumor-infiltrating immune cells in non-small cell lung cancer.

Ann Nucl Med 2020 May 4;34(5):322-328. Epub 2020 Mar 4.

Department of Nuclear Medicine of Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.

Objectives: Programmed cell death-ligand 1 (PD-L1) is expressed on tumor cells (TC) and tumor-infiltrating immune cells (IC). We conducted a retrospective study to investigate the relationship between PD-L1 expression on TC/IC and F-FDG uptake in patients with surgically resected non-small cell lung cancer (NSCLC).

Methods: Total 362 NSCLC patients (297 adenocarcinoma and 65 squamous cell carcinoma) who underwent preoperative F-FDG-PET/CT imaging were analyzed retrospectively. Read More

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http://dx.doi.org/10.1007/s12149-020-01451-0DOI Listing

Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwent Lu-DOTATOC therapy.

Ann Nucl Med 2020 Apr 29;34(4):244-253. Epub 2020 Feb 29.

Department of Nuclear Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Patients with advanced neuroendocrine tumors (NETs) of the midgut are suitable candidates for Lu-DOTATOC therapy. Integrated SPECT/CT systems have the potential to help improve the accuracy of patient-specific tumor dosimetry. Dose estimations to target organs are generally performed using the Medical Internal Radiation Dose scheme. Read More

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http://dx.doi.org/10.1007/s12149-020-01440-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101301PMC

F-FDG PET/CT in lung adenosquamous carcinoma and its correlation with clinicopathological features and prognosis.

Ann Nucl Med 2020 May 22;34(5):314-321. Epub 2020 Feb 22.

Department of Nuclear Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China.

Objective: Lung adenosquamous carcinoma (ASC) is a rare histological subtype of non-small cell lung cancer (NSCLC). Due to its rarity, the studies about F-FDG PET/CT in this kind of pulmonary tumor were quite limited. Thus, this study investigated F-FDG PET/CT findings in ASC and its correlation with clinicopathological features and clinical outcomes. Read More

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http://dx.doi.org/10.1007/s12149-020-01450-1DOI Listing
May 2020
1.507 Impact Factor

Customized FreeSurfer-based brain atlas for diffeomorphic anatomical registration through exponentiated lie algebra tool.

Ann Nucl Med 2020 Apr 22;34(4):280-288. Epub 2020 Feb 22.

Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, 20 Eonjuro 63-gil, Gangnam-gu, Seoul, Republic of Korea.

Objective: Digital brain template and atlas designed for a specific group provide advantages for the analysis and interpretation of neuroimaging data, but require a significant workload for development. We developed a simple method to create customized brain atlas for diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) tool using FreeSurfer-generated volume-of-interest (FSVOI) images and validated.

Methods: F-florbetaben positron emission tomography (PET) and magnetic resonance (MR) imaging data were obtained from 248 participants of Alzheimer's disease spectrum (from cognitively normal to Alzheimer's disease dementia). Read More

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http://dx.doi.org/10.1007/s12149-020-01445-yDOI Listing

Expert Consensus on clinical application of FDG PET/CT in infection and inflammation.

Ann Nucl Med 2020 May 21;34(5):369-376. Epub 2020 Feb 21.

Department of Nuclear Medicine, Shenzhen People's Hospital, No. 1017 Dongmen North Street, Luohu District, Shenzhen, 518020, People's Republic of China.

To further promote the clinical application of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in infection and inflammation and standardize the diagnostic process, the experts in relevant fields in China carried out discussion and formed the Expert Consensus on the clinical application of FDG PET/CT in infection and inflammation. This consensus is intended to provide a reference for imaging physicians to select a reasonable diagnostic plan. However, it should be noted that it couldn't include or solve all the problems in clinical operation. Read More

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http://dx.doi.org/10.1007/s12149-020-01449-8DOI Listing
May 2020
1.507 Impact Factor

Quantitative evaluation of salivary gland scintigraphy in Sjögren's syndrome: comparison of diagnostic efficacy and relationship with pathological features of the salivary glands.

Ann Nucl Med 2020 Apr 20;34(4):289-298. Epub 2020 Feb 20.

Department of Nuclear Medicine and Minnan PET Center, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Objective: The value of salivary gland scintigraphy (SGS) in the evaluation of Sjögren's syndrome (SS) remains controversial. The aim of this study was to evaluate the diagnostic efficacy of quantitative SGS in patients with xerostomia and to assess the correlation between scintigraphic parameters and pathological features of salivary glands.

Methods: Medical records of 165 patients with xerostomia who underwent [99mTc] pertechnetate SGS and labial biopsy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12149-020-01448-9DOI Listing
April 2020
1.507 Impact Factor

Accuracy of Oral Gallium Citrate Scintigraphy in assessment of inflammatory activity of Crohn's disease.

Ann Nucl Med 2020 Apr 19;34(4):263-271. Epub 2020 Feb 19.

Epidemiology Surveillance Department, Hospital de Base do Distrito Federal, Brasília, Brazil.

Aim: The main goal in Crohn´s disease (CD) is a sustained suppression of inflammatory activity associated with mucosa healing in endoscopic evaluation. During clinical routine, there are small numbers of good markers to monitor inflammatory activity under treatment. We postulated that Oral Gallium Citrate Scintigraphy is able to mark inflammatory disease in mucosa and deep inflammation in CD, when used in oral form. Read More

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http://dx.doi.org/10.1007/s12149-020-01447-wDOI Listing

The value of Bayesian penalized likelihood reconstruction for improving lesion conspicuity of malignant lung tumors on F-FDG PET/CT: comparison with ordered subset expectation maximization reconstruction incorporating time-of-flight model and point spread function correction.

Ann Nucl Med 2020 Apr 14;34(4):272-279. Epub 2020 Feb 14.

Department of Radiology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Objective: To evaluate the value of Bayesian penalized likelihood (BPL) reconstruction for improving lesion conspicuity of malignant lung tumors on F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography computed tomography (PET/CT) as compared with the ordered subset expectation maximization (OSEM) reconstruction incorporating time-of-flight (TOF) model and point-spread-function (PSF) correction.

Methods: Twenty-nine patients with primary or metastatic lung cancers who underwent F-FDG PET/CT were retrospectively studied. PET images were reconstructed with OSEM + TOF, OSEM + TOF + PSF, and BPL with noise penalty strength β-value of 200, 400, 600, and 800. Read More

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http://dx.doi.org/10.1007/s12149-020-01446-xDOI Listing

Phase I clinical study with different doses of Tc-TRODAT-1 in healthy adults.

Ann Nucl Med 2020 Mar 6;34(3):212-219. Epub 2020 Feb 6.

Department of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Wulumuqi Middle Road, Jing'an District, Shanghai, 200040, China.

Objectives: To study the pharmacokinetics, biodistribution, and injection doses of Tc-TRODAT-1 in healthy adults.

Methods: Thirty healthy individuals comprising 15 females and 15 males were randomly divided into three groups and the injection doses of Tc-TRODAT-1 of group 1, 2, and 3 were 370 MBq, 740 MBq, and 1110 MBq, respectively. Assessments of subjective symptoms and tests were performed before and after injection. Read More

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http://dx.doi.org/10.1007/s12149-020-01444-zDOI Listing

Reply to Zaragori et al.: "Is IDH mutation status associated with F-FDopa PET uptake".

Ann Nucl Med 2020 03;34(3):230-231

Unit of Radiotherapy, Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1007/s12149-020-01443-0DOI Listing

The role of epsilon phenotype in brain glucose consumption in Alzheimer's disease.

Ann Nucl Med 2020 Apr 3;34(4):254-262. Epub 2020 Feb 3.

Department of Biomedicine and Prevention, Faculty of Medicine and Surgery, Tor Vergata University, Rome, Italy.

Objective: The aim of our study was to investigate the impact of the epsilon phenotype in brain glucose consumption in a population with Alzheimer's disease.

Methods: Statistical Parametric Mapping (SPM8) was used to investigate differences in brain glucose consumption (as detectable by means of 18F FDG-PET/CT) in the population examined. A total of 129 patients (72 females and 57 males) with a diagnosis of probable AD according to the NINCDS-ADRDA criteria underwent the PET/CT examination. Read More

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http://dx.doi.org/10.1007/s12149-020-01441-2DOI Listing

Is IDH mutation status associated with F-FDopa PET uptake?

Ann Nucl Med 2020 03 30;34(3):228-229. Epub 2020 Jan 30.

Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, 54000, Nancy, France.

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http://dx.doi.org/10.1007/s12149-020-01442-1DOI Listing

Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm.

Ann Nucl Med 2020 Mar 27;34(3):220-227. Epub 2020 Jan 27.

Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Objective: Postoperative amnesia after surgery for anterior communicating artery aneurysm might be associated with the damage of the basal forebrain. Our purpose was to verify whether decreased regional cerebral blood flow (rCBF) in basal forebrain could be related to the degree of postoperative amnesia.

Methods: Regional voxel rCBF data analyzed using three-dimensional stereotactic surface projection on I-IMP-SPECT were compared between ten patients with postoperative amnesia and 13 normal subjects. Read More

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http://dx.doi.org/10.1007/s12149-020-01436-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033071PMC

Full report on a survey of adverse reactions to radiopharmaceuticals from 1975 to 2017 in Japan.

Ann Nucl Med 2020 Apr 27;34(4):299-304. Epub 2020 Jan 27.

Department of Radiology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Objective: This pharmacovigilance-based survey was aimed at determining the prevalence of, and association between, radiopharmaceuticals and adverse reactions to radiopharmaceuticals from 1975 to 2017 in Japan.

Methods: The Subcommittee for Safety Issues of Radiopharmaceuticals of the Japan Radioisotope Association's Medical Science and Pharmaceutical Committee mailed a form for reporting adverse reactions to radiopharmaceuticals to all institutes performing nuclear medicine examinations in Japan. This investigation included adverse reactions to diagnostic radiopharmaceuticals labeled with both single-photon- and positron-emitting radionuclides and therapeutic sodium iodide labeled with I. Read More

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http://dx.doi.org/10.1007/s12149-020-01439-wDOI Listing

Clinical implication of myocardial FDG uptake pattern in oncologic PET: retrospective comparison study with stress myocardial perfusion imaging as the reference standard.

Ann Nucl Med 2020 Apr 24;34(4):233-243. Epub 2020 Jan 24.

Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, Seiryomachi, 1-1 Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

Objective: The purpose of this study was to determine the clinical implication of the myocardial FDG uptake patterns by comparing with the results of stress myocardial perfusion imaging (MPI) as the reference standard.

Methods: By reviewing the medical records, 86 pairs of stress MPI and FDG PET/CT of 84 patients who underwent stress MPI and oncologic FDG PET/CT in 1 month were included in this study. The patterns of the myocardial FDG uptake were classified into five patterns such as 'low', 'diffuse', 'basal ring', 'focal high', and 'focal defect on diffuse high'. Read More

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http://dx.doi.org/10.1007/s12149-020-01437-yDOI Listing

Diagnostic performance of a computer-assisted diagnostic system: sensitivity of BONENAVI for bone scintigraphy in patients with disseminated skeletal metastasis is not so high.

Ann Nucl Med 2020 Mar 22;34(3):200-211. Epub 2020 Jan 22.

Department of Nuclear Medicine, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8555, Japan.

Purpose: Bone scintigraphy (BS) of disseminated skeletal metastasis is sometimes misinterpreted as normal. The use of computer-assisted diagnosis (CAD) may resolve this problem. We investigated the performance of a CAD system, BONENAVI, in the diagnosis of disseminated skeletal metastasis. Read More

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http://dx.doi.org/10.1007/s12149-020-01435-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033060PMC

Correction to: A phase 2, open-label, multi-center study to evaluate the efficacy and safety of Tc-TRODAT-1 SPECT to detect Parkinson's disease.

Ann Nucl Med 2020 01;34(1):38

Department of Nuclear Medicine, Huashan Hospital, Fudan University, No. 12 Wulumuqi Middle Road, Jing'an District, Shanghai, 200040, China.

The corresponding author of the article would like to remove "Jian Wang" in the author group. Read More

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http://dx.doi.org/10.1007/s12149-019-01434-wDOI Listing
January 2020

Ordered subset expectation maximisation vs Bayesian penalised likelihood reconstruction algorithm in 18F-PSMA-1007 PET/CT.

Ann Nucl Med 2020 Mar 4;34(3):192-199. Epub 2020 Jan 4.

Synektik Pharma, Kielce, Poland.

Background: The aim of the study was to compare widely used ordered subset expectation maximisation (OSEM) algorithm with a new Bayesian penalised likelihood (BPL) Q.Clear algorithm in 18F-PSMA-1007 PET/CT.

Methods: We retrospectively assessed 25 18F-PSMA-1007 PET/CT scans with both OSEM and Q. Read More

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http://dx.doi.org/10.1007/s12149-019-01433-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033087PMC

Diagnosis of cardiac sarcoidosis: an era of paradigm shift.

Ann Nucl Med 2020 Feb 17;34(2):87-93. Epub 2019 Dec 17.

Division of Cardiology, Department of Medicine, New York Presbyterian Hospital/Columbia University Medical Center, 622 West 168th Street, PH 10-203, New York, NY, 10032, USA.

Cardiac sarcoidosis is a granulomatous disease that may affect any organ, including the heart. Diagnosis of cardiac sarcoidosis is challenging, given the varied and non-specific clinical presentation and limited sensitivity and specificity of available diagnostic tests. With the growing interest and developments in imaging techniques, cardiac magnetic resonance imaging (CMR) and positron emission tomography (PET) have emerged as important tools in the diagnostic evaluation of patients with suspected cardiac sarcoidosis. Read More

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http://dx.doi.org/10.1007/s12149-019-01431-zDOI Listing
February 2020

Low-dose radioiodine therapy for patients with intermediate- to high-risk differentiated thyroid cancer.

Ann Nucl Med 2020 Feb 13;34(2):144-151. Epub 2019 Dec 13.

Departments of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.

Objective: The efficacy of low-dose radioiodine therapy (RIT) for intermediate-risk or high-risk differentiated thyroid cancer (DTC) patients is controversial. Because of the country's shortage of medical facilities for RIT, 1110-MBq RIT for higher risk DTC patients has been performed on an outpatient basis since 2010 in Japan. Herein, we addressed this issue and attempted to determine prognostic factors for the prediction of RIT outcomes. Read More

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http://dx.doi.org/10.1007/s12149-019-01432-yDOI Listing
February 2020

Opportunistic body composition evaluation in patients with esophageal adenocarcinoma: association of survival with F-FDG PET/CT muscle metrics.

Ann Nucl Med 2020 Mar 10;34(3):174-181. Epub 2019 Dec 10.

Department of Radiology, UC Davis School of Medicine, 4860 Y Street, Suite 3100, Sacramento, CA, 95817, USA.

Objective: F-FDG PET is widely used to accurately stage numerous types of cancers. Although F-FDG PET/CT features of tumors aid in predicting patient prognosis, there is increasing interest in mining additional quantitative body composition data that could improve the prognostic power of F-FDG PET/CT, without additional examination costs or radiation exposure. The aim of this study was to determine the association between overall survival and body composition metrics derived from routine clinical F-FDG PET/CT examinations. Read More

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http://dx.doi.org/10.1007/s12149-019-01429-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035190PMC