2,626 results match your criteria Annals of nuclear medicine[Journal]


Measurement of cerebral vascular reserves with I-123 IMP SPECT without an arterial input function using the microsphere model and radiopharmaceutical dose calibration.

Ann Nucl Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiology, Toho University, Medical Centre Oohashi, 2-22-36, Oohashi, Meguro-ku, Tokyo, Japan.

Objectives: Cerebral vascular reserve (CVR) is an important indicator for the management of and therapy for cerebral arterial occlusive disease (CAOD). Vasodilatory function is measured using the standard IMP-ARG method. The IMP autoradiography (IMP-ARG) method employed here uses a standardized input function, which was derived from 12 patients between 31 and 71 years of age. Read More

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http://dx.doi.org/10.1007/s12149-019-01336-xDOI Listing

A novel biomarker, active whole skeletal total lesion glycolysis (WS-TLG), as a quantitative method to measure bone metastatic activity in breast cancer patients.

Ann Nucl Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Nuclear Medicine, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8555, Japan.

Objective: There is no good response evaluation method for skeletal metastasis. We aimed to develop a novel quantitative method to evaluate the response of skeletal metastasis, especially lytic lesions, for treatment.

Methods: A method to measure active bone metastatic burden quantitatively using F-18 fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) in breast cancer patients, whole skeletal total lesion glycolysis (WS-TLG), a summation of each skeletal lesion's TLG, was developed. Read More

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http://dx.doi.org/10.1007/s12149-019-01359-4DOI Listing
April 2019
1 Read

Diagnostic performance of F-FDG PET-CT for large vessel involvement assessment in patients with suspected giant cell arteritis and negative temporal artery biopsy.

Ann Nucl Med 2019 Apr 11. Epub 2019 Apr 11.

Nuclear Medicine Department, Montpellier University Hospital, Montpellier, France.

Objective: The purpose of our study was to assess the diagnostic performance of F-FDG PET-CT for large vessel involvement in patients with suspected giant cells arteritis (GCA) and a negative temporal artery biopsy (TAB).

Methods: We conducted a retrospective study in a cohort of patients with suspected GCA and negative TAB who underwent an F-FDG PET-CT. Ten vascular segments were studied using a visual score and a semi-quantitative method based on SUVmax ratio with respect to liver uptake. Read More

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http://link.springer.com/10.1007/s12149-019-01358-5
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http://dx.doi.org/10.1007/s12149-019-01358-5DOI Listing
April 2019
4 Reads

Development of anatomically and lesion contrast-guided partial volume correction: new 3D formalisms and validation in phantom and clinical studies.

Ann Nucl Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Critical Care Medicine, Faculty of Medicine, Cairo University Hospitals, Cairo, Egypt.

Purpose: The aim of the study was to correct for partial volume effect in positron emission imaging studies which is the most influential factors using three-dimensional (3D) representation of the recovery coefficients (RCs) to improve standardized uptake value (SUV) calculations.

Methods: Several phantom studies were conducted at significantly wide range of lesion contrast, range 2:1 up to 15:1. It was then classified into two groups: one for generating 3D function taking into consideration the sphere size as well lesion contrast whereas the other group was used for functions validation. Read More

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http://dx.doi.org/10.1007/s12149-019-01356-7DOI Listing

Comparison between the different doses of radioactive iodine ablation prescribed in patients with intermediate-to-high-risk differentiated thyroid cancer.

Ann Nucl Med 2019 Apr 6. Epub 2019 Apr 6.

Department of Radiation Oncology and Image-Applied Therapy, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: This study aimed to compare the clinical outcomes of patients who received radioactive iodine (RAI) ablation after undergoing thyroidectomy for intermediate-to-high-risk differentiated thyroid carcinoma (DTC) according to the American Thyroid Association (ATA) criteria.

Methods: We retrospectively examined patients who underwent RAI ablation for DTC after surgical resection without macroscopic residual lesions or metastatic lesions between December 2011 and August 2016. Among 147 patients who underwent RAI ablation, those whose initial pathological stages or RAI ablation results were unknown and whose distant metastases were confirmed during RAI ablation were excluded. Read More

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http://dx.doi.org/10.1007/s12149-019-01357-6DOI Listing
April 2019
2 Reads

Development of a p38α-selective radioactive probe for qualitative diagnosis of cancer using SPECT.

Ann Nucl Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Biofunctional Analysis, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.

Objective: p38 mitogen-activated protein (MAP) kinase (p38α) has drawn attention as a new target molecule for the treatment and diagnosis of cancer, and its overexpression and activation have been reported in various types of cancer. In this study, a single photon emission computed tomography (SPECT) imaging probe of p38α was developed to noninvasively image p38α activity for effective qualitative diagnosis of cancer.

Methods: Pyrrolepyridine derivatives, m-YTM and p-YTM, were designed and synthesized based on the structure of the p38α-selective inhibitor. Read More

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http://dx.doi.org/10.1007/s12149-019-01341-0DOI Listing
April 2019
1 Read

Overall survival and progression-free survival in patients with primary brain tumors after treatment: is the outcome of [F] FDOPA PET a prognostic factor in these patients?

Ann Nucl Med 2019 Apr 4. Epub 2019 Apr 4.

Department of Biomedicine and Prevention, University "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.

Aim: To investigate the progression-free survival (PFS) and the overall survival (OS) in a population affected by primary brain tumors (PBT) evaluated by [F]-L-dihydroxyphenylalanine ([F] FDOPA) positron emission tomography/computed tomography (PET/CT).

Materials And Methods: 133 subjects with PBT (65 women and 68 men, mean age 45 ± 10 years old) underwent F FDOPA PET/CT after treatment. Of them, 68 (51. Read More

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http://link.springer.com/10.1007/s12149-019-01355-8
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http://dx.doi.org/10.1007/s12149-019-01355-8DOI Listing
April 2019
2 Reads

Prognostic role of baseline 18F-FDG PET/CT metabolic parameters in mantle cell lymphoma.

Ann Nucl Med 2019 Mar 30. Epub 2019 Mar 30.

Nuclear Medicine, University of Brescia and Spedali Civili Brescia, P.le Spedali Civili 1, 25123, Brescia, Italy.

Objective: Mantle cell lymphoma (MCL) is an aggressive lymphoma sub-type with poor prognosis and high 18F-FDG avidity at PET/CT; nowadays, no validated criteria for PET/CT in treatment response evaluation and prediction of outcome are present. The aim of study was to investigate whether the metabolic PET/CT features may predict treatment evaluation and prognosis in MCL.

Methods: We retrospectively enrolled 87 patients who underwent baseline 18F-FDG PET/CT and 85 end-of-treatment (eot) PET/CT. Read More

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http://dx.doi.org/10.1007/s12149-019-01354-9DOI Listing
March 2019
2 Reads

A systematic performance evaluation of head motion correction techniques for 3 commercial PET scanners using a reproducible experimental acquisition protocol.

Ann Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.

Purposes: Subject's motion during brain PET scan degrades spatial resolution and quantification of PET images. To suppress these effects, rigid-body motion correction systems have been installed in commercial PET scanners. In this study, we systematically compare the accuracy of motion correction among 3 commercial PET scanners using a reproducible experimental acquisition protocol. Read More

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http://dx.doi.org/10.1007/s12149-019-01353-wDOI Listing

Preliminary clinical assessment of dynamic F-fluorodeoxyglucose positron emission tomography/computed tomography for evaluating lymph node metastasis in patients with lung cancer: a prospective study.

Ann Nucl Med 2019 Mar 25. Epub 2019 Mar 25.

Department of Radiology, Tokushima University Hospital, 2-50-1, Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.

Objective: We assessed the diagnostic capacity of dynamic fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) and dual-time-point (DTP) PET/CT to explore the optimal scan timing for nodal staging in lung cancer.

Methods: Thirty-four patients with lung cancer underwent dynamic and consecutive DTP PET/CT scans. Two readers visually evaluated FDG uptake within each lymph node (LN) and pulmonary artery (metastatic LN: n = 10; nonmetastatic LN: n = 121). Read More

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http://dx.doi.org/10.1007/s12149-019-01350-zDOI Listing
March 2019
1 Read

I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults.

Ann Nucl Med 2019 Mar 21. Epub 2019 Mar 21.

Institute of Neuroscience, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.

Objective: I-123-2β-Carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane (FP-CIT) imaging is an established biomarker used in the diagnosis of Lewy body disease. Images are often reported with the aid of striatal binding ratios (SBRs), comparing uptake to a normal database via Z scores. It is well known that SBRs are age dependent. Read More

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http://dx.doi.org/10.1007/s12149-019-01352-xDOI Listing
March 2019
2 Reads

The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function.

Ann Nucl Med 2019 Mar 18. Epub 2019 Mar 18.

Sleep Apnea Center, Kyushu University Hospital, Fukuoka, Japan.

Objective: Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer's disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.

Method: We performed polysomnography (PSG) and Aβ imaging with [C]-Pittsburgh compound B PET computed tomography (C-PiB PET CT) in 14 untreated OSAS patients (apnea-hypopnea index: 43. Read More

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http://dx.doi.org/10.1007/s12149-019-01349-6DOI Listing
March 2019
1 Read

Potential utility of bone scan in cranial bone flap osteomyelitis.

Ann Nucl Med 2019 Mar 18. Epub 2019 Mar 18.

Department of Nuclear Medicine, East Group Hospital, Hospices Civils de Lyon, 59 Bvd Pinel, 69634, Lyon Cedex, France.

Objective: Currently, the diagnosis of bone flap osteomyelitis (BFO) remains a challenge for medical imaging. The present study aimed to identify predictive scintigraphic patterns of BFO.

Methods: This retrospective study reviewed planar bone scan of patients with suspected BFO between 2010, and 2016. Read More

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http://dx.doi.org/10.1007/s12149-019-01351-yDOI Listing

F-NaF-PET/CT for the detection of bone metastasis in prostate cancer: a meta-analysis of diagnostic accuracy studies.

Ann Nucl Med 2019 Mar 15. Epub 2019 Mar 15.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: This meta-analysis aims to establish the diagnostic performance of F-NaF-PET/CT for the detection of bone metastases in prostate cancer patients. The performance of F-NaF-PET/CT was compared with other imaging techniques in the same cohort of patients.

Methods: A systematic search was performed in PubMed/Medline and EMBASE (last Updated, September 28, 2018). Read More

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http://dx.doi.org/10.1007/s12149-019-01343-yDOI Listing
March 2019
2 Reads

Preliminary results of biodistribution and dosimetric analysis of [Ga]Ga-DOTA: a new zoledronate-based bisphosphonate for PET/CT diagnosis of bone diseases.

Ann Nucl Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Nuclear Medicine, University Medical Center Bonn, Bonn, Germany.

Objective: Pre-clinical studies with gallium-68 zoledronate ([Ga]Ga-DOTA) have proposed it to be a potent bisphosphonate for PET/CT diagnosis of bone diseases and diagnostic counterpart to [Lu]Lu-DOTA and [Ac]Ac-DOTA. This study aims to be the first human biodistribution and dosimetric analysis of [Ga]Ga-DOTA.

Methods: Five metastatic skeletal disease patients (mean age: 72 years, M: F; 4:1) were injected with 150-190 MBq (4. Read More

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http://dx.doi.org/10.1007/s12149-019-01348-7DOI Listing

Impaired brain dopamine transporter in chemobrain patients submitted to brain SPECT imaging using the technetium-99m labeled tracer TRODAT-1.

Ann Nucl Med 2019 Apr 7;33(4):269-279. Epub 2019 Mar 7.

Imaging Department, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo, CEP 05651-901, Brazil.

Purpose: "Chemobrain" is a medical secondary effect of cancer chemotherapy treatment characterized by a general decline in cognition affecting visual and verbal memory, attention, complex problem-solving skills, and motor function. Dopamine (DA) central nervous system neurotransmitters serve an important role in cognition, and changes in DA could potentially explain impaired cognition associated with chemotherapy. Therefore, our objective was to assess in vivo dopaminergic dysfunction in the central nervous system (CNS) of a group of female breast cancer survivors with cognitive impairment following chemotherapy. Read More

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http://link.springer.com/10.1007/s12149-019-01331-2
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http://dx.doi.org/10.1007/s12149-019-01331-2DOI Listing
April 2019
11 Reads

Distribution of LAT1-targeting PET tracer was independent of the tumor blood flow in rat xenograft models of C6 glioma and MIA PaCa-2.

Ann Nucl Med 2019 Feb 28. Epub 2019 Feb 28.

Department of Nuclear Medicine and Tracer Kinetics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Objective: L-type amino acid transporter 1 (LAT1) is strongly expressed on the cell membrane in various types of human cancer cells, while being minimally expressed in normal or inflammatory tissues. Therefore, LAT1-targeting PET tracers have been developed for cancer-specific imaging. The purpose of this study was to study the distribution of two LAT1-targeting PET tracers, L-4-borono-2-F-fluoro-phenylalanine (F-FBPA) and L-3-F-alpha-methyl tyrosine (F-FAMT), in relation to the tumor blood flow, using rat xenograft models. Read More

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http://dx.doi.org/10.1007/s12149-019-01346-9DOI Listing
February 2019
1 Read

4-Borono-2-F-fluoro-L-phenylalanine PET for boron neutron capture therapy-oriented diagnosis: overview of a quarter century of research.

Authors:
Kiichi Ishiwata

Ann Nucl Med 2019 Apr 28;33(4):223-236. Epub 2019 Feb 28.

Southern TOHOKU Drug Discovery and Cyclotron Research Center, Southern TOHOKU Research Institute for Neuroscience, 7-61-2 Yatsuyamada, Koriyama, 963-8052, Japan.

4-B-Borono-2-F-fluoro-L-phenylalanine (F-FBPA) was developed for monitoring the pharmacokinetics of 4-B-borono-L-phenylalanine (B-BPA) used in boron neutron capture therapy (BNCT) with positron emission tomography (PET). The tumor-imaging potential of F-FBPA was demonstrated in various animal models. Accumulation of F-FBPA was higher in melanomas than in non-melanoma tumors in animal models and cell cultures. Read More

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http://dx.doi.org/10.1007/s12149-019-01347-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450856PMC

The use of 3'-deoxy-3'-F-fluorothymidine (FLT) PET in the assessment of long-term survival in breast cancer patients treated with neoadjuvant chemotherapy.

Ann Nucl Med 2019 Feb 27. Epub 2019 Feb 27.

Wayne State University School of Medicine, 540 E Canfield St, Detroit, MI, 48201, USA.

Objective: To assess the role of serial FLT-PET scans during early neoadjuvant treatment as a prognostic marker of response to treatment and survival.

Methods: This study is a prospective cohort study which draws from a larger original study which examined the utility of FLT-PET imaging across multiple cancers. Our cohort consisted of patients who had biopsy-confirmed breast cancer amenable to surgical resection. Read More

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http://dx.doi.org/10.1007/s12149-019-01345-wDOI Listing
February 2019

Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site.

Ann Nucl Med 2019 Feb 22. Epub 2019 Feb 22.

Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.

Objective: Amyloid-β plaques and neurofibrillary tangles composed of tau protein are the neuropathological hallmarks of Alzheimer's disease. In recent years, marked progress has been made in Alzheimer's disease research using tau ligands for positron emission tomography (PET). However, the issue of off-target binding, that is, the binding of ligands to regions without tau pathology, remains unresolved. Read More

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http://dx.doi.org/10.1007/s12149-019-01344-xDOI Listing
February 2019
2 Reads

Prognostic role of ΔMTV and ΔTLG in Burkitt lymphoma.

Ann Nucl Med 2019 Apr 20;33(4):280-287. Epub 2019 Feb 20.

Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy.

Objective: Burkitt's lymphoma (BL) is an aggressive lymphoma sub-type with high 18F-FDG avidity, but no well established evidence of PET/CT's role in treatment evaluation or prognosis is currently available. The prognostic role of visual analysis and Deauville criteria for BL have already been demonstrated, while the potential usefulness of semi-quantitative PET/CT features remains unclear, especially the value of the rate of reduction in metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The aim of this retrospective study was to investigate whether ΔMTV and ΔTLG can predict treatment response at the end of therapy and prognosis in BL. Read More

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http://dx.doi.org/10.1007/s12149-019-01338-9DOI Listing
April 2019
1 Read

Clinicopathological predictors of positive Ga-PSMA-11 PET/CT in PSA-only recurrence of localized prostate cancer following definitive therapy.

Ann Nucl Med 2019 Feb 18. Epub 2019 Feb 18.

Department of Urology, School of Medicine, Hacettepe University, Sihhiye, Ankara, 06100, Turkey.

Objective: To demonstrate the effect of clinicopathological factors on Ga-PSMA-11 PET/CT positivity at the time of biochemical recurrence (BCR) of localized prostate cancer (PCa) following definitive therapy.

Methods: We retrospectively reviewed our institutional database for PCa patients who had BCR and subsequently underwent Ga-PSMA-11 PET/CT between April 2014 and February 2018. A total of 51 patients who were metastasis-free before PSMA imaging and previously treated with definitive therapy (radical prostatectomy or external beam radiotherapy) for localized disease (pT1c-T3b pN0-1 cM0) were included. Read More

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http://link.springer.com/10.1007/s12149-019-01340-1
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http://dx.doi.org/10.1007/s12149-019-01340-1DOI Listing
February 2019
10 Reads

Evaluation of whole-body tumor burden with Ga-PSMA PET/CT in the biochemical recurrence of prostate cancer.

Ann Nucl Med 2019 Feb 11. Epub 2019 Feb 11.

Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil.

Background: 68 Ga-PSMA-PET has an increasing importance in the evaluation of prostate cancer patients due to its high sensitivity and specificity in identifying neoplastic lesions in the clinical setting of elevated prostate-specific antigen (PSA). The objective of this study was to calculate the whole-body tumor burden using volumetric quantification of lesions detected in Ga-PSMA-PET of prostate cancer patients with biochemical recurrence and correlate these findings with clinical and image parameters.

Methods: Each patient had their Ga-PSMA-PET analyzed for the presence of neoplastic lesions. Read More

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http://link.springer.com/10.1007/s12149-019-01342-z
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http://dx.doi.org/10.1007/s12149-019-01342-zDOI Listing
February 2019
11 Reads

Development of radiolabeled bis(zinc(II)-dipicolylamine) complexes for cell death imaging.

Ann Nucl Med 2019 Feb 6. Epub 2019 Feb 6.

Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

Purpose: Although it has been traditionally surmised that phosphatidylserine (PS) externalization is a hallmark of apoptosis, most other non-apoptotic modes of cell death, such as necrosis, are also associated with PS externalization. Bis(zinc-dipicolylamine) (ZnDPA) complexes have been reported to exhibit affinity for PS. The present study aimed to develop novel radiolabeled ZnDPA derivatives for cell death imaging in tumor after treatment with anticancer drugs. Read More

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http://dx.doi.org/10.1007/s12149-019-01339-8DOI Listing
February 2019
1 Read

Verification of image quality and quantification in whole-body positron emission tomography with continuous bed motion.

Ann Nucl Med 2019 Apr 1;33(4):288-294. Epub 2019 Feb 1.

Department of Radiology, Juntendo University School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Objective: Whole-body dynamic imaging using positron emission tomography (PET) facilitates the quantification of tracer kinetics. It is potentially valuable for the differential diagnosis of tumors and for the evaluation of therapeutic efficacy. In whole-body dynamic PET with continuous bed motion (CBM) (WBDCBM-PET), the pass number and bed velocity are key considerations. Read More

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http://dx.doi.org/10.1007/s12149-019-01334-zDOI Listing
April 2019
1 Read

Accumulation of hypoxia imaging probe "F-FMISO" in macrophages depends on macrophage polarization in addition to hypoxic state.

Ann Nucl Med 2019 Jan 29. Epub 2019 Jan 29.

Laboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan.

Objective: Macrophages play an essential role in immune response, and are closely related to the progression of diseases such as cancer and atherosclerosis. Macrophages polarize to M1 or M2 type, which is related to the environmental hypoxic state. Previously, we found that F-FMISO uptake varied according to expression levels of biomolecules such as glutathione S-transferase P1 (GST-P1), which catalyzes the conjugation of glutathione to F-FMISO metabolites, and multidrug resistance-associated protein 1 (MRP1), which exports glutathione-F-FMISO metabolite conjugates out of cells. Read More

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http://dx.doi.org/10.1007/s12149-019-01332-1DOI Listing
January 2019

Increased F-FDG accumulation in the tonsils after chemotherapy for pediatric lymphoma: a common physiological phenomenon.

Ann Nucl Med 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajiicho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Objective: Increased F-fluorodeoxyglucose (FDG) uptake in the tonsils after the completion of chemotherapy in patients with lymphoma may be misdiagnosed as tumor recurrence. This study aimed to investigate the changes in physiological FDG uptake in the tonsils during and after chemotherapy in pediatric patients with lymphoma.

Methods: A total of 47 FDG-PET/CT scans acquired from 13 pediatric patients with lymphoma (before chemotherapy [preC] = 9; during chemotherapy [durC] = 12; within 1 month after the end of chemotherapy [endC] = 11; and after achieving complete response [postC] = 15) were retrospectively included in this study. Read More

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http://dx.doi.org/10.1007/s12149-019-01337-wDOI Listing
January 2019

Effect of respiratory motion on cardiac defect contrast in myocardial perfusion SPECT: a physical phantom study.

Ann Nucl Med 2019 Jan 24. Epub 2019 Jan 24.

Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.

Objective: Correction for respiratory motion in myocardial perfusion imaging requires sorting of emission data into respiratory windows where the intra-window motion is assumed to be negligible. However, it is unclear how much intra-window motion is acceptable. The aim of this study was to determine an optimal value of intra-window residual motion. Read More

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http://link.springer.com/10.1007/s12149-019-01335-y
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http://dx.doi.org/10.1007/s12149-019-01335-yDOI Listing
January 2019
8 Reads

An assessment of bone-seeking radionuclides for palliation of metastatic bone pain in a vertebral model.

Ann Nucl Med 2019 Apr 18;33(4):252-264. Epub 2019 Jan 18.

Physics Department, Faculty of Science, University of Guilan, Rasht, Iran.

Objective: Bone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan.

Methods: The MCNPX code was used to simulate the radiation transport in a vertebral phantom. Read More

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http://dx.doi.org/10.1007/s12149-019-01329-wDOI Listing

18F-FDG uptake in the normal appendix in adults: PET/CT evaluation.

Ann Nucl Med 2019 Apr 16;33(4):265-268. Epub 2019 Jan 16.

Department of Radiology, Oita University Faculty of Medicine, Yufu City, Oita, 879-5593, Japan.

Objective: This study aimed to determine the level of F fluorodeoxyglucose (F-FDG) activity in the normal adult appendix using positron emission tomography/computed tomography (PET/CT).

Materials And Methods: We performed a retrospective review of PET/CT images using F-FDG in 563 consecutive asymptomatic adult patients without appendiceal pathology. We excluded 257 patients for an undetected or obscured appendix and three patients for appendicitis found on CT imaging. Read More

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http://dx.doi.org/10.1007/s12149-019-01330-3DOI Listing

F-DOPA uptake does not correlate with IDH mutation status and 1p/19q co-deletion in glioma.

Ann Nucl Med 2019 Apr 3;33(4):295-302. Epub 2019 Jan 3.

Radiation Oncology Unit, UPMC Hillman Cancer Center, San Pietro Hospital FBF, Rome, Italy.

Objective: The role of amino acid positron emission tomography (PET) in glioma grading and outcome prognostication has not yet been well established. This is particularly true in the context of the new WHO 2016 classification, which introduced a definition of glioma subtypes primarily based on molecular fingerprints. The aim of the present study was to correlate 3,4‑dihydroxy‑6‑[F]‑fluoro-L‑phenylalanine (F-DOPA) uptake parameters with IDH mutation, 1p/19q status, and survival outcomes in patients with glioma. Read More

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http://dx.doi.org/10.1007/s12149-018-01328-3DOI Listing

Distribution of bone tracer uptake in symptomatic knees after ACL reconstruction compared to asymptomatic non-operated knees: a method for better differentiating patient-specific from disease-specific bone tracer uptake in SPECT/CT.

Ann Nucl Med 2019 Mar 3;33(3):201-210. Epub 2019 Jan 3.

Institute of Radiology and Nuclear Medicine, Kantonsspital Baselland, 4101, Bruderholz, Switzerland.

Objective: To evaluate the differences of bone tracer uptake (BTU) in symptomatic and asymptomatic contralateral knees in patients after reconstruction of the anterior cruciate ligament (ACL-R) and to identify typical BTU patterns and threshold values to differentiate pathological from physiological BTU.

Methods: 53 patients after unilateral ACL-R were retrospectively included in the study. The population was subdivided into a group of symptomatic operated knees and a group of contralateral asymptomatic non-operated knees. Read More

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http://dx.doi.org/10.1007/s12149-018-01324-7DOI Listing
March 2019
1.507 Impact Factor

Fundamental study of radiogallium-labeled aspartic acid peptides introducing octreotate derivatives.

Ann Nucl Med 2019 Apr 3;33(4):244-251. Epub 2019 Jan 3.

Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Objective: Somatostatin receptors are highly expressed in neuroendocrine tumors, and many radiolabeled somatostatin analogs for diagnosis and treatment have been developed. To simultaneously detect not only primary cancer but also bone metastases, this study aimed to develop a positron emission tomography probe using generator-produced nuclide Gallium-68 (T = 68 min), in which a carrier for primary cancer, a carrier for bone metastases lesions, and a stable gallium complex are introduced into the one molecule. Based on this strategy, the somatostatin receptor-targeted peptide, [Tyr]-octreotate (TATE), aspartic acid peptide (D) with high binding affinity for hydroxyapatite, and Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) as a stable gallium complex were selected. Read More

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http://dx.doi.org/10.1007/s12149-018-01326-5DOI Listing
April 2019
2 Reads

Brain F-FDG distribution: which region is most affected by increased plasma glucose levels?

Ann Nucl Med 2019 04 2;33(4):303-304. Epub 2019 Jan 2.

Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.

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http://dx.doi.org/10.1007/s12149-018-01327-4DOI Listing

F-FDG and C-choline uptake in proliferating tumor cells is dependent on the cell cycle in vitro.

Ann Nucl Med 2019 Apr 26;33(4):237-243. Epub 2018 Dec 26.

Division of Dental Radiology, School of Dentistry, Iwate Medical University, 1-3-27 Chuodori, Morioka, Iwate, 020-8505, Japan.

Objective: Among different PET tracers, F-fludeoxyglucose (FDG) and C-choline are known to have a high tumor uptake correlated with a high mitotic index of tumor cells. Thus, the uptake of F-FDG and C-choline may be dependent on the cell cycle. In the present study, we examined the uptake of F-FDG and C-choline in cancer cell lines by cell cycle synchronization to clarify the biological properties of cancer cells with respect to each tracer. Read More

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http://dx.doi.org/10.1007/s12149-018-01325-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450840PMC

Response evaluation with F-FDG PET/CT in metastatic breast cancer patients treated with Palbociclib: first experience in clinical practice.

Ann Nucl Med 2019 Mar 19;33(3):193-200. Epub 2018 Dec 19.

Nuclear Medicine Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Francesco Vito, 1, 00168, Rome, Italy.

Objective: Palbociclib is a cyclin-dependent kinase 4/6 inhibitor recently approved for treatment in advanced or metastatic breast cancer (BC) patients. The use of F-FDG PET/CT for chemo/endocrine therapy response assessment in BC patients is well reported in the literature, but no studies have evaluated its role for assessing Palbociclib efficacy in clinical practice. Our study aimed to evaluate the potential role of F-FDG PET/CT in this setting. Read More

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http://dx.doi.org/10.1007/s12149-018-01323-8DOI Listing
March 2019
3 Reads

Clinical value of F-FDG-PET/CT in suspected serious disease with special emphasis on occult cancer.

Ann Nucl Med 2019 Mar 19;33(3):184-192. Epub 2018 Dec 19.

Department of Radiology and Nuclear Medicine, Hospital of Southwest Jutland, Finsensgade 35, 6700, Esbjerg, Denmark.

Purpose: Suspected serious disease (SSD) is a disease designation often given to patients with one or more non-specific symptoms of severe disease that could be due to cancer; the optimal diagnostic strategy is largely left to the clinician's discretion. Being a sensitive non-invasive whole-body imaging modality F-FDG-PET/CT may have a potential role in this cancer-prevalent group of patients to confirm or refute suspected malignancy. We aimed to investigate the diagnostic value of F-FDG-PET/CT in SSD using long-term follow-up as reference. Read More

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http://dx.doi.org/10.1007/s12149-018-01322-9DOI Listing

Impact factors for the outcome of the first I radiotherapy in patients with papillary thyroid carcinoma after total thyroidectomy.

Ann Nucl Med 2019 Mar 4;33(3):177-183. Epub 2018 Dec 4.

Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Objective: To investigate the impact factors of the outcome of the first I treatment in patients with papillary thyroid carcinoma (PTC) after total thyroidectomy.

Methods: Three hundred and fifty-three patients [256 females, 97 males, average age (43.58 ± 12. Read More

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http://dx.doi.org/10.1007/s12149-018-01321-wDOI Listing

Introduction of the targeted alpha therapy (with Radium-223) into clinical practice in Japan: learnings and implementation.

Ann Nucl Med 2019 Mar 27;33(3):211-221. Epub 2018 Nov 27.

Department of Nuclear Medicine, Faculty of Medicine, Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Ishikawa Prefecture, Japan.

Radium-223 dichloride (Ra-223) is the first targeted alpha therapy approved for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone metastasis. Ra-223 improved overall survival in the international Phase III ALSYMPCA (ALpharadin in SYMPtomatic Prostate Cancer) study. Ra-223 was also demonstrated to be efficacious and safe in Japanese patients in Phase I and Phase II clinical trials. Read More

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http://dx.doi.org/10.1007/s12149-018-1317-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397713PMC

Investigation of the relation between administered dose and image quality for pediatric Tc-DMSA renal scintigraphy: clinical study applying the JSNM (Japanese Society of Nuclear Medicine) pediatric dosage card : The Japanese Society of Nuclear Medicine Technology (JSNMT), the Optimization of Imaging Technique Committee for Pediatric Nuclear Medicine Studies.

Ann Nucl Med 2019 Mar 27;33(3):153-159. Epub 2018 Nov 27.

Department of Radiology, Jikei University Hospital, 3-19-18 Nishishimbashi, Minato-ku, Tokyo, 105-8471, Japan.

Purpose: In 2013, the Japanese Society of Nuclear Medicine (JSNM) announced consensus guidelines for pediatric nuclear medicine. These JSNM guidelines proposed use of lower administered doses compared with traditionally determined doses, which were estimated from age, weight or body surface area (BSA) based on the administered dose for adults in Japan. When the JSNM guidelines are used, the relationship between this recommended administered dose and image quality remains unclear. Read More

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http://dx.doi.org/10.1007/s12149-018-1320-6DOI Listing
March 2019
2 Reads

Comparison between single photon emission computed tomography with computed tomography and planar scintigraphy in sentinel node biopsy in breast cancer patients.

Ann Nucl Med 2019 Mar 19;33(3):160-168. Epub 2018 Nov 19.

Departments of Nuclear Medicine, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Objective: Radio-guided sentinel node (SN) biopsy is a standard method used in the treatment of early breast cancer. Single photon emission computed tomography with computed tomography (SPECT/CT) has been commonly used for SN detection. SPECT/CT adds precise anatomical information of SN sites, and it is reported that more SNs may be detectable on SPECT/CT than on planar imaging. Read More

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http://dx.doi.org/10.1007/s12149-018-1319-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397712PMC
March 2019
12 Reads

Clinical evaluation of CT radiation dose in whole-body F-FDG PET/CT in relation to scout imaging direction and arm position.

Ann Nucl Med 2019 Mar 10;33(3):169-176. Epub 2018 Nov 10.

Department of Radiology, Kitasato University Hospital, Sagamihara, Japan.

Objective: Radiation exposure in CT is modulated by automatic exposure control (AEC) mainly based on scout images. We evaluated CT radiation dose in whole-body PET/CT in relation to scout imaging direction and arm position, and investigated the behavior of AEC.

Methods: Eighty adult patients who underwent whole-body F-FDG PET/CT were divided into groups A, B, C, and D. Read More

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http://link.springer.com/10.1007/s12149-018-1318-0
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http://dx.doi.org/10.1007/s12149-018-1318-0DOI Listing
March 2019
16 Reads

Phase I/IIa PET imaging study with zirconium labeled anti-PSMA minibody for urological malignancies.

Ann Nucl Med 2019 Feb 7;33(2):119-127. Epub 2018 Nov 7.

Department of Urology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Objective: We conducted the present phase I/IIa positron emission tomography (PET) imaging study with Zr conjugated with desferroxamine-IAB2M (Zr-Df-IAB2M), an anti-prostate-specific membrane-antigen minibody, to assess its safety and feasibility in patients with urological cancer.

Methods: Zr-Df-IAB2M was synthetized by IBA Molecular (Somerset, NJ, USA) and transported by air to Tsukuba Molecular Imaging Center (Tsukuba, Ibaraki, Japan).17 patients received 74 MBq (2 mCi) of Zr-Df-IAB2M at total mass doses of 10 mg. Read More

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http://link.springer.com/10.1007/s12149-018-1312-6
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http://dx.doi.org/10.1007/s12149-018-1312-6DOI Listing
February 2019
17 Reads

The RECIST criteria compared to conventional response evaluation after peptide receptor radionuclide therapy in patients with neuroendocrine neoplasms.

Ann Nucl Med 2019 Mar 7;33(3):147-152. Epub 2018 Nov 7.

Department of Gastroenterology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, 0424, Oslo, Norway.

Objective: The Response Evaluation Criteria In Solid Tumors (RECIST) is the most used radiological method for evaluating response after peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine tumors. This method may give too positive estimates of response in slow growing tumors as it allows a substantial increase in tumor size before patients are classified as having progressive disease. We wanted to compare RECIST with a conventional method in routine use for estimating treatment effect based on defining any unequivocal increase in size of tumor load as progressive disease. Read More

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http://link.springer.com/10.1007/s12149-018-1316-2
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http://dx.doi.org/10.1007/s12149-018-1316-2DOI Listing
March 2019
14 Reads

[Tc]3PRGD for integrin receptor imaging of esophageal cancer: a comparative study with [F]FDG PET/CT.

Ann Nucl Med 2019 Feb 3;33(2):135-143. Epub 2018 Nov 3.

Department of Nuclear Medicine, the 1st Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Objectives: This study was designed to investigate the efficacy of technetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([Tc]3PRGD) in the evaluation of patients with esophageal cancer.

Methods: Twenty-nine patients with a suspected esophageal lesion and for whom definite pathological diagnosis was finally obtained were recruited. Whole-body planar scanning and chest single-photon-emission computed tomography/computed tomography (SPECT/CT) were performed at 30 and 40 min, respectively, after intravenous injection of 11. Read More

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http://dx.doi.org/10.1007/s12149-018-1315-3DOI Listing
February 2019
6 Reads

An enhanced treatment effect can be expected from a higher serum thyroglobulin level after radioactive iodine therapy.

Ann Nucl Med 2019 Feb 31;33(2):128-134. Epub 2018 Oct 31.

Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences (KIRAMS), 75, Nowon-ro, Nowon-gu, Seoul, 139-706, Republic of Korea.

Objective: The aim of this study was to investigate if increased serum thyroglobulin (Tg) levels after radioactive iodine (RAI) showed more therapeutic effects in patients with differentiated thyroid cancer (DTC).

Methods: Data of 65 patients with DTC who underwent RAI from June 2014 to September 2016 were reviewed. Serum thyroglobulin was measured immediately before (Tg1) and 48 h (Tg2) after RAI under TSH stimulation. Read More

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http://dx.doi.org/10.1007/s12149-018-1313-5DOI Listing
February 2019
2 Reads

Negative remnant Tc-pertechnetate uptake predicts excellent response to radioactive iodine therapy in low- to intermediate-risk differentiated thyroid cancer patients who have undergone total thyroidectomy.

Ann Nucl Med 2019 Feb 29;33(2):112-118. Epub 2018 Oct 29.

Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.

Objective: Negative Tc-pertechnetate uptake of the thyroid bed indicates the absence or a small volume of remnant thyroid tissue (RTT) after total thyroidectomy (TT). The aim of this study is to evaluate the predictive value of negative Tc-pertechnetate scintigraphy for excellent response (ER) to radioactive iodine therapy (RIT) in low- to intermediate-risk differentiated thyroid cancer (DTC) patients.

Patients: One-hundred and eighty-nine low- to intermediate-risk DTC patients who underwent TT, RIT with a single dose of 30 mCi and suppressive therapy with thyroid-stimulating hormone (TSH) from July 2015 to February 2016 in our hospital were retrospectively evaluated. Read More

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http://link.springer.com/10.1007/s12149-018-1314-4
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http://dx.doi.org/10.1007/s12149-018-1314-4DOI Listing
February 2019
16 Reads

Techniques for generating attenuation map using cardiac SPECT emission data only: a systematic review.

Ann Nucl Med 2019 Jan 22;33(1):1-13. Epub 2018 Oct 22.

Department of Medical Physics and Biomedical engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

To reliably interpret and perform quantitative analysis, attenuation correction for cardiac single-photon emission computed tomography (SPECT) is fundamental. Thus, knowledge of the patient-specific attenuation map for accurate correction is required in SPECT quantitative imaging. The aim of this systematic review is to present general principles of attenuation correction and provide a structured summary of the approaches that have been proposed for generating the attenuation map for cardiac SPECT. Read More

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http://dx.doi.org/10.1007/s12149-018-1311-7DOI Listing
January 2019

The role of N-ammonia in the differential diagnosis of gliomas and brain inflammatory lesions.

Ann Nucl Med 2019 Jan 22;33(1):61-67. Epub 2018 Oct 22.

Department of Nuclear Medicine, The First Affiliated Hospital of Sun Yat-Sen University, 58#, Zhongshan Er Road, Guangzhou, 510080, China.

Objective: To investigate the utility of N-ammonia PET/CT imaging in the differential diagnosis of gliomas and brain inflammations.

Methods: N-ammonia PET/CT imaging data of 77 patients with gliomas and 34 patients with brain inflammations were retrospectively analyzed. No patients received any treatment before N-ammonia imaging. Read More

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http://link.springer.com/10.1007/s12149-018-1308-2
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http://dx.doi.org/10.1007/s12149-018-1308-2DOI Listing
January 2019
4 Reads

Characteristics of iodine-123 IQ-SPECT/CT imaging compared with conventional SPECT/CT.

Ann Nucl Med 2019 Feb 15;33(2):103-111. Epub 2018 Oct 15.

Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.

Objectives: Although the utility of IQ-SPECT imaging using Tc and Tl myocardial perfusion SPECT has been reported, I-labeled myocardial SPECT has not been fully evaluated. We determined the characteristics and utility of I IQ-SPECT imaging compared with conventional SPECT (C-SPECT).

Methods: Two myocardial phantom patterns were used to simulate normal myocardium and myocardial infarction. Read More

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http://link.springer.com/10.1007/s12149-018-1310-8
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http://dx.doi.org/10.1007/s12149-018-1310-8DOI Listing
February 2019
5 Reads