11,058 results match your criteria Annals of neurology[Journal]


Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.

Ann Neurol 2018 Jun 16. Epub 2018 Jun 16.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

Objective: Previous gene expression analysis identified a network of co-expressed genes that is associated with β-amyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets.

Methods: Data came from 834 community-based older persons who were followed annually, died and underwent brain autopsy. Read More

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Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.

Ann Neurol 2018 Jun 16. Epub 2018 Jun 16.

UCSF Weill Institute for Neurosciences. University of California San Francisco, San Francisco, CA 94143, USA.

Objective: Primary progressive multiple sclerosis (PPMS) causes accumulation of neurologic disability from disease onset without clinical attacks typical of relapsing multiple sclerosis (RMS). However, whether genetic variation influences the disease course remains unclear. We aimed to determine whether mutations causative of neurologic disorders that share features with MS contribute to risk for developing PPMS. Read More

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Repair after brainstem ischemia involves neurogenesis and the rubrospinal system.

Ann Neurol 2018 Jun 16. Epub 2018 Jun 16.

Dept. of Neurology, Division of Stroke Recovery and Neurorestoration and Division of Cerebrovascular Diseases.

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Oligonucleotide therapy mitigates disease in Spinocerebellar Ataxia Type 3 mice.

Ann Neurol 2018 Jun 16. Epub 2018 Jun 16.

Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, USA.

Objective: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common dominantly inherited ataxia. Despite advances in understanding this CAG repeat/polyglutamine expansion disease, there are still no therapies to alter its progressive fatal course. Here we investigate whether an antisense oligonucleotide (ASO) targeting the SCA3 disease gene, ATXN3, can prevent molecular, neuropathological, electrophysiological and behavioral features of the disease in a mouse model of SCA3. Read More

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Collaborative Science Unites Researchers and a Novel Spastic Ataxia Gene.

Authors:
Brent L Fogel

Ann Neurol 2018 Jun 16. Epub 2018 Jun 16.

Departments of Neurology and Human Genetics, David Geffen School of Medicine, University of California Los Angeles, California, 90095, USA.

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Filter-Probe Diffusion Imaging Improves Spinal Cord Injury Outcome Prediction.

Ann Neurol 2018 May 11. Epub 2018 May 11.

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI.

Objective: Diffusion weighted imaging (DWI) is a powerful tool for investigating spinal cord injury (SCI), but has limited specificity for axonal damage- the most predictive feature of long-term functional outcome. In this study, a technique designed to detect acute axonal injury, filter-probe double diffusion encoding (FP-DDE) is compared with standard DWI for predicting long-term functional and cellular outcomes.

Methods: This study extends FP-DDE to predict long-term functional and histological outcomes in a rat SCI model of varying severities(n=58). Read More

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Chronic Traumatic Encephalopathy and Age of First Exposure To American-style Football.

Ann Neurol 2018 May 11. Epub 2018 May 11.

Physical Medicine and Rehabilitation, Brigham and Women's Hospital, Massachusetts General Hospital, and Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA.

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Reply to "Cortico-pallidal connectivity: Lessons from patients with dystonia".

Ann Neurol 2018 May 8. Epub 2018 May 8.

Division of Neurology, Department of Medicine, University of Toronto and Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

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Intriguing association of Parkinson disease and epileptic seizures.

Ann Neurol 2018 May 8. Epub 2018 May 8.

Epidemiology Department, University Clinical Center Niš, Serbia.

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Prodromal symptoms of multiple sclerosis in primary care.

Ann Neurol 2018 May 8. Epub 2018 May 8.

Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland.

Objective: Early diagnosis and treatment initiation significantly influence long-term disability outcome in multiple sclerosis (MS). We aimed at identifying prodromal symptoms of MS in primary care settings.

Methods: This was a nested case-control study comparing the occurrence of various symptoms in MS patients versus controls at 0 to 2, 2 to 5, and 5 to 10 years before index date (first MS record). Read More

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May 2018
1 Read

De novo gain-of-function variants in KCNT2 as a novel cause of developmental and epileptic encephalopathy.

Ann Neurol 2018 May 8. Epub 2018 May 8.

Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig, Germany.

Variants in several potassium channel genes have been found in developmental and epileptic encephalopathies (DEE). We report two females with de novo variants in KCNT2 with West syndrome followed by Lennox-Gastaut syndrome or with DEE with migrating focal seizures. After in vitro analysis suggested quinidine-responsive gain-of-function effects, we treated one of the girls with quinidine add-on therapy and achieved marked clinical improvements. Read More

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Integrated MRI and [ C]-PBR28 PET Imaging in Amyotrophic Lateral sclerosis.

Ann Neurol 2018 May 8. Epub 2018 May 8.

Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Objective: To characterize [ C]-PBR28 brain uptake using positron emission tomography (PET) in people with amyotrophic lateral sclerosis (ALS), and primary lateral sclerosis (PLS). We have previously shown increased [ C]-PBR28 uptake in the precentral gyrus in a small group of ALS patients. Herein, we confirm our initial finding, study the longitudinal changes, and characterize the gray vs. Read More

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Recurrent SCN3A p.Ile875Thr variant in patients with polymicrogyria.

Ann Neurol 2018 May 8. Epub 2018 May 8.

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, 236-0004, Japan.

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Cortico-pallidal connectivity: Lessons from patients with dystonia.

Ann Neurol 2018 May 8. Epub 2018 May 8.

IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.

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Reply to: "Recurrent SCN3A p.Ile875Thr variant in patients with polymicrogyria".

Ann Neurol 2018 May 8. Epub 2018 May 8.

Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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Randomized trial of lacosamide vs fosphenytoin for nonconvulsive seizures.

Ann Neurol 2018 May 7. Epub 2018 May 7.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Objective: The optimal treatment of nonconvulsive seizures in critically ill patients is uncertain. We evaluated the comparative effectiveness of antiseizure drugs (ASD) lacosamide (LCM) and fosphenytoin (fPHT) in this population.

Methods: The Treatment of Recurrent Electrographic Nonconvulsive Seizures (TRENdS) study was a non-inferiority, prospective, multicenter, randomized treatment trial of patients diagnosed with NCS by continuous electroencephalography (cEEG). Read More

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May 2018
33 Reads

Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome.

Ann Neurol 2018 May 7. Epub 2018 May 7.

Department of Neurology, McGovern Medical School at University of Texas Health Science Center Houston, Texas, 77030.

Objective Chronic systemic inflammation contributes to the pathogenesis of many age-related diseases. Although not well understood, alterations in the gut microbiota, or dysbiosis, may be responsible for age-related inflammation. Methods Using stroke as a disease model, we tested the hypothesis that a youthful microbiota, when established in aged mice, produces positive outcomes following ischemic stroke. Read More

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Subthalamic nucleus deep brain stimulation evokes resonant neural activity.

Ann Neurol 2018 May 4. Epub 2018 May 4.

Bionics Institute, East Melbourne, Victoria, Australia.

Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large-amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. Read More

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Age of First Exposure to Tackle Football and Chronic Traumatic Encephalopathy.

Ann Neurol 2018 Apr 30. Epub 2018 Apr 30.

Boston University Alzheimer's Disease and CTE Center, Department of Neurology, Boston University School of Medicine.

Objective: To examine the effect of age of first exposure to tackle football on CTE pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically-confirmed CTE.

Methods: The sample included 246 tackle football players who donated their brains for neuropathological examination. 211 were diagnosed with CTE (126/211 were without comorbid neurodegenerative diseases) and 35 were without CTE. Read More

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April 2018
1 Read

Congenital titinopathy: Comprehensive characterisation and pathogenic insights.

Ann Neurol 2018 Apr 25. Epub 2018 Apr 25.

Harry Perkins Institute of Medical Research, University of Western Australia, Nedlands, WA, Australia.

Objective: Comprehensive clinical characterisation of congenital titinopathy to facilitate diagnosis and management of this important emerging disorder.

Methods: Using massively parallel sequencing we identified 30 patients from 27 families with two pathogenic nonsense, frameshift and/or splice site TTN mutations in trans. We then undertook a detailed analysis of the clinical, histopathology and imaging features of these patients. Read More

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April 2018
3 Reads

Intravenous thrombolysis in unwitnessed stroke onset: MR WITNESS trial results.

Ann Neurol 2018 Apr 24. Epub 2018 Apr 24.

Dell Medical School, University of Texas at Austin, Austin, TX.

Objective: Most acute ischemic stroke (AIS) patients with unwitnessed symptom onset are ineligible for intravenous thrombolysis due to timing alone. Lesion evolution on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) correlates with stroke duration, and quantitative mismatch of diffusion-weighted MRI with FLAIR (qDFM) might indicate stroke duration within guideline-recommended thrombolysis. We tested whether intravenous thrombolysis ≤4. Read More

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April 2018
3 Reads

Erratum: fetal growth and premature delivery in pregnant women on antiepileptic drugs.

Ann Neurol 2018 Apr;83(4):872

Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA.

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Feasibility, Safety and Outcome of Recanalisation Treatment in Childhood Stroke.

Ann Neurol 2018 Apr 20. Epub 2018 Apr 20.

Department of Pediatrics, Division of Child Neurology, University Children's Hospital Bern, University of Bern, Bern, Switzerland.

Objective Intravenous thrombolysis and endovascular therapy (IVT/EVT) are evidence-based treatments for adults with arterial ischemic stroke (AIS). However, randomized controlled trials in pediatric patients are lacking. This study aimed to describe feasibility, safety, and outcome of IVT/EVT in children with AIS. Read More

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April 2018
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A probiotic modulates the microbiome and immunity in multiple sclerosis.

Ann Neurol 2018 Apr 20. Epub 2018 Apr 20.

Ann Romney Center for Neurologic Diseases, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Objective: Effect of a probiotic on the gut microbiome and peripheral immune function in healthy controls and relapsing-remitting multiple sclerosis (MS) patients.

Methods: MS patients (N = 9) and controls (N = 13) were orally administered a probiotic containing Lactobacillus, Bifidobacterium, and Streptococcus twice-daily for two months. Blood and stool specimens were collected at baseline, after completion of the 2-month treatment, and 3 months after discontinuation of therapy. Read More

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April 2018
1 Read

Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy.

Ann Neurol 2018 Apr 20. Epub 2018 Apr 20.

Institute for Genomic Medicine, Columbia University, New York, NY.

Objective: Somatic variants are a recognized cause of epilepsy-associated focal malformations of cortical development (MCD). We hypothesized that somatic variants may underlie a wider range of focal epilepsy, including nonlesional focal epilepsy (NLFE). Through genetic analysis of brain tissue, we evaluated the role of somatic variation in focal epilepsy with and without MCD. Read More

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April 2018
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Defining mechanisms of neural plasticity after brainstem ischemia in rats.

Ann Neurol 2018 Apr 17. Epub 2018 Apr 17.

Department of Neurology, Bethel-EvKB, Bielefeld, Germany.

Objective: Neurological recovery after stroke mainly depends on the location of the lesion. A substantial portion of strokes affects the brainstem. However, patterns of neural plasticity following brainstem ischemia are almost unknown. Read More

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April 2018
1 Read

How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder.

Ann Neurol 2018 Apr 17. Epub 2018 Apr 17.

Department of Psychology, Université du Québec à Montréal, Montreal, QC, Canada.

Objective: We describe the progression of cognitive decline and identify the predictive values of cognitive tests in three groups of REM sleep behavior disorder (RBD) patients classified at their last follow-up as having Parkinson's disease (PD), dementia with Lewy bodies (DLB), or still-idiopathic.

Methods: Patients (n = 109) underwent polysomnographic, neurological, and neuropsychological assessments. We used linear mixed-model analyses to compare the progression of cognitive test performance between the three groups over a 3-year prodromal period, and performed linear regressions for a 6-year prodromal period. Read More

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April 2018
3 Reads

Atrophy and microglial distribution in primary progressive aphasia with transactive response DNA-binding protein-43 kDa.

Ann Neurol 2018 Apr 17. Epub 2018 Apr 17.

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL.

Objective: To quantitatively determine the density and distribution of activated microglia across cortical regions and hemispheres in the brains of primary progressive aphasia (PPA) participants with pathological diagnoses of frontotemporal lobar degeneration with transactive response DNA-binding protein-43 (TDP-43) inclusions and to examine the relationships between microglial densities, patterns of focal atrophy, (TDP-43) inclusions, and clinical phenotype.

Methods: Activated microglia and TDP-43 inclusions were visualized in whole-hemisphere brain sections using immunohistochemical methods from five participants with PPA-TDP. Unbiased stereology was used to bilaterally quantify human leuckocyte antigen/D related-positive activated microglia and TDP-43 inclusions across five language-related regions. Read More

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April 2018
2 Reads

Newborn screening: A disease-changing intervention for glutaric aciduria type 1.

Ann Neurol 2018 Apr 17. Epub 2018 Apr 17.

Division of Child Neurology and Metabolic Medicine, Center for Child and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.

Objective: Untreated individuals with glutaric aciduria type 1 (GA1) commonly present with a complex, predominantly dystonic movement disorder (MD) following acute or insidious onset striatal damage. Implementation of GA1 into newborn screening (NBS) programs has improved the short-term outcome. It remains unclear, however, whether NBS changes the long-term outcome and which variables are predictive. Read More

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April 2018
1 Read

Serotonin, β-amyloid, and cognition in Parkinson disease.

Ann Neurol 2018 Apr 17. Epub 2018 Apr 17.

Department of Neurology, University of Michigan.

Objective: Serotoninergic neurotransmission may modulate β-amyloid peptide (Aβ) metabolism through upregulation of α-secretase. Early Parkinson disease (PD) shows variable serotoninergic denervation, which may impact Aβ deposition.

Methods: We conducted 3 analyses to explore associations between serotoninergic neurotransmission and cerebral Aβ burden in PD. Read More

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April 2018
1 Read

Intrathecal immunoglobulin M production: A promising high-risk marker in clinically isolated syndrome patients.

Ann Neurol 2018 Apr 17. Epub 2018 Apr 17.

Department of Neurology, University Hospital Ulm, Ulm.

Markers predicting the course of patients with clinically isolated syndrome (CIS) toward multiple sclerosis (MS) are urgently needed. We evaluated the predictive values of intrathecal immunoglobulin (Ig) G and IgM production with different methods for conversion to definite MS according to revised McDonald 2010 criteria in a cohort of 126 CIS patients. Intrathecal IgM production showed the highest likelihood ratio for the conversion of CIS patients to definite MS at 6. Read More

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April 2018
1 Read

Tuning in C-nociceptors to reveal mechanisms in chronic neuropathic pain.

Ann Neurol 2018 Apr 16. Epub 2018 Apr 16.

Department of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Objective: Develop and validate a low-intensity sinusoidal electrical stimulation paradigm to preferentially activate C-fibers in human skin.

Methods: Sinusoidal transcutaneous stimulation (4Hz) was assessed psychophysically in healthy volunteers (n = 14) and neuropathic pain patients (n = 9). Pursuing laser Doppler imaging and single nociceptor recordings in vivo in humans (microneurography) and pigs confirmed the activation of "silent" C-nociceptors. Read More

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April 2018
1 Read

Continuous electroencephalography predicts delayed cerebral ischemia after subarachnoid hemorrhage: A prospective study of diagnostic accuracy.

Ann Neurol 2018 Apr 16. Epub 2018 Apr 16.

Epilepsy Service and Division of Clinical Neurophysiology, Massachusetts General Hospital, Boston, MA.

Objective: Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI is a key focus of neurocritical care, but interventions carry risk and cannot be applied indiscriminately. Although retrospective studies have identified continuous electroencephalographic (cEEG) measures associated with DCI, no study has characterized the accuracy of cEEG with sufficient rigor to justify using it to triage patients to interventions or clinical trials. Read More

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April 2018
2 Reads

Epidemiology of autoimmune versus infectious encephalitis.

Ann Neurol 2018 Apr 10. Epub 2018 Apr 10.

Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine.

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April 2018
1 Read

Blood pressure and risk of incident Alzheimer's disease dementia by antihypertensive medications and APOE ε4 allele.

Ann Neurol 2018 Apr 10. Epub 2018 Apr 10.

Department of Internal Medicine, Rush University Medical Center, Chicago, IL.

Objective: To examine the association of blood pressure (BP) with incident Alzheimer's disease (AD) dementia.

Methods: This work is based on a longitudinal, cohort study of 18 years, the Chicago Health and Aging Project (CHAP) performed in 2,137 participants (55% black) with systolic BP measured around 8.1 years before incident AD dementia. Read More

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April 2018
1 Read

Reply to "Epidemiology of autoimmune versus infectious encephalitis".

Ann Neurol 2018 Apr 10. Epub 2018 Apr 10.

Department of Neurology, Mayo Clinic, Rochester.

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April 2018
1 Read

Ischemic stroke in cancer patients: A review of an underappreciated pathology.

Ann Neurol 2018 Apr 6. Epub 2018 Apr 6.

Department of Neurology.

Currently 1 in 10 patients with ischemic stroke have comorbid cancer, and this frequency is expected to increase with continued advances in cancer therapeutics prolonging median survival. Well known for its association with venous thrombosis, cancer has recently emerged as a significant risk factor for arterial thromboembolism, including stroke; however, the underlying mechanisms are uncertain. In addition, the optimal strategies to prevent and acutely treat stroke in cancer patients are yet to be established. Read More

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April 2018
1 Read

The epilepsy phenotypic spectrum associated with a recurrent CUX2 variant.

Ann Neurol 2018 Apr 6. Epub 2018 Apr 6.

Department of Medical Genetics, Lyon University Hospital and GENDEV team CNRS UMR 5292, INSERM U1028, CRNL, and University Claude Bernard Lyon 1, GHE, Lyon, France.

Objective: Cut homeodomain transcription factor CUX2 plays an important role in dendrite branching, spine development, and synapse formation in layer II to III neurons of the cerebral cortex. We identify a recurrent de novo CUX2 p.Glu590Lys as a novel genetic cause for developmental and epileptic encephalopathy (DEE). Read More

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April 2018
3 Reads

Permeability of the blood-brain barrier predicts no evidence of disease activity at 2 years after natalizumab or fingolimod treatment in relapsing-remitting multiple sclerosis.

Ann Neurol 2018 Mar 31. Epub 2018 Mar 31.

Functional Imaging Unit, Department of Clinical Physiology, Nuclear Medicine, and PET, Rigshospitalet, Copenhagen, Denmark.

Objective: To investigate whether blood-brain barrier (BBB) permeability, as measured by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), can provide early detection of suboptimal treatment response in relapsing-remitting multiple sclerosis (RRMS).

Methods: Thirty-five RRMS patients starting on fingolimod or natalizumab, drugs with a common effect of decreasing lymphocyte influx into the central nervous system, were scanned with DCE-MRI at 3T prior to treatment and at 3 and 6 months posttreatment. We calculated the influx constant K , a measure of BBB permeability, using the Patlak model. Read More

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March 2018
10 Reads

Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1.

Ann Neurol 2018 Mar 31. Epub 2018 Mar 31.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Objective: Defective mitochondrial function attributed to optic atrophy 1 (OPA1) mutations causes primarily optic atrophy and, less commonly, neurodegenerative syndromes. The pathomechanism by which OPA1 mutations trigger diffuse loss of neurons in some, but not all, patients is unknown. Here, we used a tractable induced pluripotent stem cell (iPSC)-based model to capture the biology of OPA1 haploinsufficiency in cases presenting with classic eye disease versus syndromic parkinsonism. Read More

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March 2018
3 Reads

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects.

Ann Neurol 2018 Mar 31. Epub 2018 Mar 31.

Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, 48109, USA.

Objective: To identify novel causes of recessive ataxias, including spinocerebellar ataxia with saccadic intrusions, spastic ataxias and spastic paraplegia.

Methods: In an international collaboration, we independently performed exome sequencing in seven families with recessive ataxia and/or spastic paraplegia. To evaluate the role of VPS13D mutations, we evaluated a Drosophila knock-out model and investigated mitochondrial function in patient-derived fibroblast cultures. Read More

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March 2018
1 Read

Neurochemical abnormalities in premanifest and early spinocerebellar ataxias.

Ann Neurol 2018 Apr 10;83(4):816-829. Epub 2018 Apr 10.

Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN.

Objective: To investigate whether early neurochemical abnormalities are detectable by high-field magnetic resonance spectroscopy (MRS) in individuals with spinocerebellar ataxias (SCAs) 1, 2, 3, and 6, including patients without manifestation of ataxia.

Methods: A cohort of 100 subjects (N = 18-21 in each SCA group, including premanifest mutation carriers; mean score on the Scale for the Assessment and Rating of Ataxia [SARA] <10 for all genotypes, and 22 matched controls) was scanned at 7 Tesla to obtain neurochemical profiles of the cerebellum and brainstem. A novel multivariate approach (distance-weighted discrimination) was used to combine regional profiles into an "MRS score. Read More

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April 2018
2 Reads

Even when right is all that's left: There are still more options for recovery from aphasia.

Ann Neurol 2018 Apr;83(4):661-663

Department of Neurology; Division of Stroke Recovery and Neurorestoration, and Division of Cerebrovascular Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

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April 2018
3 Reads

Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.

Ann Neurol 2018 Apr;83(4):863-869

Department of Neurology, Christian-Albrechts-University Kiel, Germany.

We performed a genome-wide association study in 1,194 controls and 150 patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR, n = 96) or anti-leucine-rich glioma-inactivated1 (anti-LGI1, n = 54) autoimmune encephalitis. Anti-LGI1 encephalitis was highly associated with 27 single-nucleotide polymorphisms (SNPs) in the HLA-II region (leading SNP rs2858870 p = 1.22 × 10 , OR = 13. Read More

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April 2018
2 Reads

Regional brain volumetry and brain function in severely brain-injured patients.

Ann Neurol 2018 Apr 10;83(4):842-853. Epub 2018 Apr 10.

Coma Science Group, GIGA Consciousness, University of Liège, Liège, Belgium.

Objective: The relationship between residual brain tissue in patients with disorders of consciousness (DOC) and the clinical condition is unclear. This observational study aimed to quantify gray (GM) and white matter (WM) atrophy in states of (altered) consciousness.

Methods: Structural T1-weighted magnetic resonance images were processed for 102 severely brain-injured and 52 healthy subjects. Read More

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April 2018
2 Reads

Enhancing swallowing recovery after a stroke by harnessing its bihemispheric organization.

Ann Neurol 2018 Apr 10;83(4):658-660. Epub 2018 Apr 10.

Associate Editor, Annals of Neurology Department of Neurology, Division of Stroke Recovery and Neurorestoration and Division of Cerebrovascular Diseases Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

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April 2018
2 Reads

Status epilepticus: Role for etiology in determining response to benzodiazepines.

Ann Neurol 2018 Apr 10;83(4):830-841. Epub 2018 Apr 10.

Department of Pediatrics, University of Virginia, Charlottesville, VA.

Objective: Clinical factors contributing to benzodiazepine failure in treating status epilepticus (SE) include suboptimal dosing and seizure duration. As many benzodiazepine-refractory episodes of SE arise from acute etiologies, we sought to determine whether etiology impacts SE treatment.

Methods: The potency of diazepam to terminate SE induced by lithium-pilocarpine (LiPilo-SE) or kainic acid (KA-SE) in 3-week-old rats was studied by video-electroencephalography. Read More

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April 2018
3 Reads
9.98 Impact Factor

Developmental conduction aphasia after neonatal stroke.

Ann Neurol 2018 Apr;83(4):664-675

Great Ormond Street Institute of Child Health, Developmental Neurosciences Programme, University College London.

Objective: Impairment of speech repetition following injury to the dorsal language stream is a feature of conduction aphasia, a well-described "disconnection syndrome" in adults. The impact of similar lesions sustained in infancy has not been established.

Methods: We compared language outcomes in term-born individuals with confirmed neonatal stroke (n = 30, age = 7-18 years, left-sided lesions in 21 cases) to matched controls (n = 40). Read More

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April 2018
2 Reads

Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy.

Ann Neurol 2018 Apr 10;83(4):858-862. Epub 2018 Apr 10.

Department of Neurology, Massachusetts General Hospital, Boston, MA.

We hypothesize that epileptiform abnormalities (EAs) in the electroencephalogram (EEG) during the acute period following traumatic brain injury (TBI) independently predict first-year post-traumatic epilepsy (PTE ). We analyze PTE risk factors in two cohorts matched for TBI severity and age (n = 50). EAs independently predict risk for PTE (odds ratio [OR], 3. Read More

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April 2018
1 Read