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    10875 results match your criteria Annals of neurology[Journal]

    1 OF 218

    Dendritic spines provide cognitive resilience against Alzheimer's disease.
    Ann Neurol 2017 Sep 16. Epub 2017 Sep 16.
    Center for Neurodegeneration and Experimental Therapeutics.
    Objective: Neuroimaging and other biomarker assays suggest that the pathological processes of Alzheimer's disease (AD) initiate years prior to clinical dementia onset. However some 30%-50% of older individuals that harbor AD pathology do not become symptomatic in their lifetime. It is hypothesized that such individuals exhibit cognitive resilience that protects against AD dementia. Read More

    Bicycling suppresses abnormal beta synchrony in the Parkinsonian basal ganglia.
    Ann Neurol 2017 Sep 11. Epub 2017 Sep 11.
    Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
    Objective: Freezing of gait is a poorly understood symptom of Parkinson's disease, and can severely disrupt the locomotion of affected patients. However, bicycling ability remains surprisingly unaffected in most patients suffering from freezing suggesting functional differences in the motor network. The purpose of this study was to characterize and contrast the oscillatory dynamics underlying bicycling and walking in the basal ganglia. Read More

    Deconstructing normal pressure hydrocephalus: Ventriculomegaly as early sign of neurodegeneration.
    Ann Neurol 2017 Sep 11. Epub 2017 Sep 11.
    Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, University Health Network, University of Toronto, Toronto, ON, Canada.
    Idiopathic normal pressure hydrocephalus (NPH) remains both over-suspected on clinical grounds and under-confirmed when based on immediate and sustained response to cerebrospinal fluid diversion. Poor long-term post-shunt benefits and findings of neurodegenerative pathology in most patients with adequate follow up suggests that hydrocephalic disorders appearing in late adulthood may often result from initially unapparent parenchymal abnormalities. We critically review the NPH literature, highlighting the near universal lack of blinding and controls, the absence of specific clinical, imaging, or pathologic features, and the ongoing dependence for diagnostic confirmation on variable cutoffs of gait response to bedside fluid-drainage testing. Read More

    DNAJC12 and dopa-responsive non-progressive Parkinsonism.
    Ann Neurol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy.
    Biallelic DNAJC12 mutations were described in children with hyperphenylalaninemia, neurodevelopmental delay, and dystonia. We identified DNAJC12 homozygous null variants (c.187A>T;p. Read More

    Brain-heart interactions reveal consciousness in non-communicating patients.
    Ann Neurol 2017 Sep 11. Epub 2017 Sep 11.
    Institut du Cerveau et de la Moelle épinière, 47 bd de l'Hôpital, 75013, Paris, France.
    Objective We here aimed at characterizing heart-brain interactions in patients with disorders of consciousness. We tested how this information impacts data-driven classification between unresponsive and minimally conscious patients. Methods A cohort of 127 patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS, n=70) and minimally conscious state (MCS, n=57) were presented with the 'Local-Global' auditory oddball paradigm, which distinguishes two levels of processing: short-term deviation of local auditory regularities and global long-term rule violations. Read More

    Mutations of KIF14 Cause Primary Microcephaly by Impairing Cytokinesis.
    Ann Neurol 2017 Sep 11. Epub 2017 Sep 11.
    Cologne Center for Genomics (CCG), University of Cologne, D-50931, Cologne, Germany.
    Objective: Autosomal recessive primary microcephaly (MCPH) is a rare condition characterized by a reduced cerebral cortex accompanied with intellectual disability. Mutations in 17 genes have been shown to cause this phenotype. Recently, mutations in CIT, encoding CRIK (Citron Rho-interacting kinase) - a component of the central spindle matrix, were added. Read More

    Alcohol improves cerebellar-learning deficit in myoclonus-dystonia - a clinical and electrophysiological investigation.
    Ann Neurol 2017 Sep 4. Epub 2017 Sep 4.
    Institute of Neurogenetics, University of Lübeck, Germany.
    Objectives: To characterize neurophysiological subcortical abnormalities in myoclonus-dystonia and their modulation by alcohol administration.

    Methods: Cerebellar associative learning and basal ganglia-brainstem interaction were investigated in 17 myoclonus-dystonia patients with epsilon-sarcoglycan (SGCE) gene mutation and 21 age- and sex-matched healthy controls by means of classical eyeblink conditioning and blink reflex recovery cycle before and after alcohol intake resulting in a breath alcohol concentration of 0.08% (0. Read More

    Internal Grant Review to Increase Grant Funding for Junior Investigators.
    Ann Neurol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Decreasing biomedical research support over the past decade has driven many talented young scientists to seek careers outside academia. In 2011, the Department of Neurology at Johns Hopkins University School of Medicine developed an internal grant review program (IGRP) to systematically review career development awards (CDAs) and research grants (e.g. Read More

    Concussion in adolescence and risk of multiple sclerosis.
    Ann Neurol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Clinical Neuroscience, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
    Objective: To assess whether concussion in childhood or adolescence is associated with subsequent multiple sclerosis risk. Previous research suggests an association but methodological limitations included retrospective data collection and small study populations.

    Methods: The national Swedish Patient (hospital diagnoses) and Multiple Sclerosis registers were used to identify all MS diagnoses up to 2012 among people born from 1964, when the Patient Register was established. Read More

    Thiamine deficiency in childhood with attention to genetic causes: Survival and outcome predictors.
    Ann Neurol 2017 Jul 18. Epub 2017 Jul 18.
    Division of Child Neurology, Sant Joan de Déu Hospital, University of Barcelona, Barcelona, Spain.
    Primary and secondary conditions leading to thiamine deficiency have overlapping features in children, presenting with acute episodes of encephalopathy, bilateral symmetric brain lesions, and high excretion of organic acids that are specific of thiamine-dependent mitochondrial enzymes, mainly lactate, alpha-ketoglutarate, and branched chain keto-acids. Undiagnosed and untreated thiamine deficiencies are often fatal or lead to severe sequelae. Herein, we describe the clinical and genetic characterization of 79 patients with inherited thiamine defects causing encephalopathy in childhood, identifying outcome predictors in patients with pathogenic SLC19A3 variants, the most common genetic etiology. Read More

    GABBR2 mutations determine phenotype in Rett syndrome and epileptic encephalopathy.
    Ann Neurol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
    Objective: Rett syndrome (RTT) and epileptic encephalopathy (EE) are devastating neurodevelopmental disorders with distinct diagnostic criteria. However, highly heterogeneous and overlapping clinical features often allocate patients into the boundary of the two conditions, complicating accurate diagnosis and appropriate medical interventions. Therefore, we investigated the specific molecular mechanism that allows an understanding of the pathogenesis and relationship of these two conditions. Read More

    Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis.
    Ann Neurol 2017 Aug 30. Epub 2017 Aug 30.
    INSERM UMR-S1118, faculté de médecine, Strasbourg, 67085, France.
    Objective: Spasticity occurs in a wide range of neurological diseases, including neurodegenerative diseases, after trauma or after stroke and is characterized by increased reflexes leading to muscle hypertonia. Spasticity is a painful symptom and can severely restrict everyday life, but might also participate in maintaining a low level of motor function in severely impaired patients. Constitutive activity of the serotonin receptors 5-HT2B/C is required for the development of spasticity after spinal cord injury or during amyotrophic lateral sclerosis (ALS). Read More

    Fetal Growth and Premature Delivery in Pregnant Women on Anti-epileptic Drugs.
    Ann Neurol 2017 Aug 30. Epub 2017 Aug 30.
    North American AED Pregnancy Registry. MassGeneral Hospital for Children, Boston, Massachusetts.
    Objective: To evaluate the effects of epilepsy and antiepileptic drugs (AED) use during pregnancy on fetal growth and preterm delivery.

    Methods: This study included singleton liveborns born to women enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2016. Data were collected prospectively through telephone interviews. Read More

    Dysregulation of LIMK-1/Cofilin-1 pathway: A possible basis for alteration of neuronal morphology in experimental cerebral malaria.
    Ann Neurol 2017 Aug 26. Epub 2017 Aug 26.
    Department of Biotechnology and Bioinformatics, School of life Sciences, University of Hyderabad, Hyderabad, 500046, Telangana, India.
    Objective: Loss of cognition even after survival is the salient feature of cerebral malaria (CM). Currently, the fate of neuronal morphology is not studied at the ultra-structural level in CM. Recent studies suggest that maintenance of neuronal morphology and dendritic spine density (actin dynamics in particular) are essential for proper cognitive functions. Read More

    Insufficient sleep: Enhanced risk-seeking relates to low local sleep intensity.
    Ann Neurol 2017 Aug 21. Epub 2017 Aug 21.
    Department of Neurology, University Hospital Zurich, University of Zurich, Switzerland.
    Objectives: Chronic sleep restriction is highly prevalent in modern society and is in its clinical form, insufficient sleep syndrome, one of the most prevalent diagnoses in clinical sleep laboratories, with substantial negative impact on health and community burden. It reflects every-day sleep loss better than acute sleep deprivation, but its effects and particularly the underlying mechanisms remain largely unknown for a variety of critical cognitive domains, as for example risky decision-making.

    Methods: We assessed financial risk-taking behavior after 7 consecutive nights of sleep restriction and after one night of acute sleep deprivation compared to a regular sleep condition in a within-subject design. Read More

    Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic REM sleep behavior disorder.
    Ann Neurol 2017 Aug 22. Epub 2017 Aug 22.
    Nuclear Medicine Service, Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain.
    Objective: To determine the usefulness of dopamine transporter (DAT) imaging to identify idiopathic REM sleep behavior disorder (IRBD) patients at risk for short-term development of clinically-defined synucleinopathy.

    Methods: Eighty-seven patients with polysomnography-confirmed IRBD underwent (123) I-FP-CIT DAT-SPECT. Results were compared with 20 matched controls without RBD who underwent DAT-SPECT. Read More

    Inhibiting persistent inward sodium currents prevents myotonia.
    Ann Neurol 2017 Aug 18. Epub 2017 Aug 18.
    Department of Neuroscience, Cell Biology, and Physiology, Wright State University, Dayton, OH.
    Objective: Patients with myotonia congenita have muscle hyperexcitability due to loss-of-function mutations in the ClC-1 chloride channel in skeletal muscle, which causes involuntary firing of muscle action potentials (myotonia), producing muscle stiffness. The excitatory events that trigger myotonic action potentials in the absence of stabilizing ClC-1 current are not fully understood. Our goal was to identify currents that trigger spontaneous firing of muscle in the setting of reduced ClC-1 current. Read More

    Persistent seizure control in epileptic mice transplanted with GABA progenitors.
    Ann Neurol 2017 Aug 18. Epub 2017 Aug 18.
    Epilepsy Research Laboratory, Department of Neurological Surgery and Weill Institute for Neurosciences, University of California, San Francisco, California, 94143, USA.
    Objective A significant proportion of the more than 50 million people world-wide currently suffering with epilepsy are resistant to antiepileptic drugs (AEDs). As an alternative to AEDs, novel therapies based on cell transplantation offer an opportunity for long-lasting modification of epileptic circuits. To develop such a treatment requires careful preclinical studies in a chronic epilepsy model featuring unprovoked seizures, hippocampal histopathology, and behavioral comorbidities. Read More

    Cortical pathology in multiple sclerosis detected by the T1/T2-weighted ratio from routine magnetic resonance imaging.
    Ann Neurol 2017 Aug 18. Epub 2017 Aug 18.
    Department of Neurology, Rechts der Isar Hospital, Technical University of Munich, Munich, Germany.
    Objective: In multiple sclerosis, neuropathological studies have shown widespread changes in the cerebral cortex. In vivo imaging is critical, because the histopathological substrate of most measurements is unknown.

    Methods: Using a novel magnetic resonance imaging analysis technique, based on the ratio of T1- and T2-weighted signal intensities, we studied the cerebral cortex of a large cohort of patients in early stages of multiple sclerosis. Read More

    T1-/T2-weighted ratio differs in demyelinated cortex of multiple sclerosis.
    Ann Neurol 2017 Aug 18. Epub 2017 Aug 18.
    Department of Neuroscience, Lerner Research Institute, Cleveland Clinic.
    Detecting cortical demyelination in patients with multiple sclerosis (MS) is difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted and T2-weighted images (T1w/T2w) may be sensitive to cortical myelin levels. In this MRI-histological study, postmortem in situ scans were acquired from six cadavers with MS on a 3 Tesla MRI. Read More

    Axonal components of nerves innervating the human arm.
    Ann Neurol 2017 Aug 18. Epub 2017 Aug 18.
    Christian Doppler Laboratory for Restoration of Extremity Function, Medical University of Vienna, Vienna, Austria.
    Objective: Axons traveling within the brachial plexus are responsible for the dexterous control of human arm and hand movements. Despite comprehensive knowledge on the topographical anatomy of nerves innervating the human upper limbs, the definite quantity of sensory and motor axons within this neural network remains elusive. Our aim was to perform a quantitative analysis of the axonal components of human upper limb nerves based on highly specific molecular features from spinal cord level to the terminal nerves at wrist level. Read More

    MicroRNA-137 and microRNA-195* inhibit vasculogenesis in brain arteriovenous malformations.
    Ann Neurol 2017 Aug 12. Epub 2017 Aug 12.
    Neuroscience and Neuroengineering Research Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
    Objective: Brain arteriovenous malformations (AVMs) are the most common cause of nontraumatic intracerebral hemorrhage in young adults. The genesis of brain AVM remains enigmatic. We investigated microRNA (miRNA) expression and its contribution to the pathogenesis of brain AVMs. Read More

    Natural history of Charcot-Marie-Tooth disease during childhood.
    Ann Neurol 2017 Aug 10. Epub 2017 Aug 10.
    The University of Sydney, Sydney Children's Hospitals Network (Randwick and Westmead, Sydney, New South Wales Australia.
    Objective: To determine the rate of disease progression in a longitudinal natural history study of children with Charcot-Marie-Tooth disease (CMT).

    Methods: 206 (103 female) participants aged 3-20 years enrolled in the Inherited Neuropathies Consortium were assessed at baseline and 2-years. Demographic, anthropometric, and diagnostic information were collected. Read More

    Gustatory and olfactory responses to stimulation of the human insula.
    Ann Neurol 2017 Aug 10. Epub 2017 Aug 10.
    Central Integration of Pain Team, Lyon Neuroscience Research Center, National Institute of Health and Medical Research Unit 1028, National Center for Scientific Research Mixed Unit of Research 5292, Lyon.
    Objective: Despite numerous studies suggesting the role of insular cortex in the processing of gustatory and olfactory inputs, the exact location of olfactogustatory representation in the insula remains controversial. Here we provide a functional mapping of olfactory-gustatory responses to stimulation of the human insular cortex.

    Methods: We reviewed 651 electrical stimulations of the insula that were performed in 221 patients, using stereotactically implanted depth electrodes, during the presurgical evaluation of drug-refractory epilepsy. Read More

    Very high-frequency oscillations: Novel biomarkers of the epileptogenic zone.
    Ann Neurol 2017 Aug;82(2):299-310
    Institute of Scientific Instruments, Czech Academy of Sciences, Brno, Czech Republic.
    Objective: In the present study, we aimed to investigate depth electroencephalographic (EEG) recordings in a large cohort of patients with drug-resistant epilepsy and to focus on interictal very high-frequency oscillations (VHFOs) between 500Hz and 2kHz. We hypothesized that interictal VHFOs are more specific biomarkers for epileptogenic zone compared to traditional HFOs.

    Methods: Forty patients with focal epilepsy who underwent presurgical stereo-EEG (SEEG) were included in the study. Read More

    Body weight is a robust predictor of clinical progression in Huntington disease.
    Ann Neurol 2017 Aug 5. Epub 2017 Aug 5.
    Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.
    Unintended weight loss is a hallmark of Huntington disease (HD), but it is unknown to what extent weight loss impacts the rate of disease progression. Therefore, using longitudinal data from the Enroll-HD study, we assessed the association between baseline body mass index (BMI) and the rate of clinical progression in 5,821 HD mutation carriers. We found that high baseline BMI was associated with a significantly slower rate of functional, motor, and cognitive deterioration (all p < 0. Read More

    Brexanolone as adjunctive therapy in super-refractory status epilepticus.
    Ann Neurol 2017 Aug 5. Epub 2017 Aug 5.
    Sage Therapeutics, Inc., Cambridge, MA.
    Objective: Super-refractory status epilepticus (SRSE) is a life-threatening form of status epilepticus that continues or recurs despite 24 hours or more of anesthetic treatment. We conducted a multicenter, phase 1/2 study in SRSE patients to evaluate the safety and tolerability of brexanolone (USAN; formerly SAGE-547 Injection), a proprietary, aqueous formulation of the neuroactive steroid, allopregnanolone. Secondary objectives included pharmacokinetic assessment and open-label evaluation of brexanolone response during and after anesthetic third-line agent (TLA) weaning. Read More

    Seizure activity per se does not induce tissue damage markers in human neocortical focal epilepsy.
    Ann Neurol 2017 Jul 27. Epub 2017 Jul 27.
    Epilepsy Unit, C. Besta Neurological Institute Foundation.
    Objective: The contribution of recurring seizures to the progression of epileptogenesis is debated. Seizure-induced brain damage is not conclusively demonstrated either in humans or in animal models of epilepsy. We evaluated the expression of brain injury biomarkers on postsurgical brain tissue obtained from 20 patients with frequent seizures and a long history of drug-resistant focal epilepsy. Read More

    Myelopathy in Behçet's disease: The Bagel Sign.
    Ann Neurol 2017 Aug 10;82(2):288-298. Epub 2017 Aug 10.
    Mayo Clinic College of Medicine, Department of Neurology, Rochester, MN.
    Objective: To describe the clinical and distinctive imaging features of myelopathy associated with Behçet's disease (BD).

    Methods: We evaluated the records of patients meeting the following criteria: (1) fulfillment of the International Study Group criteria for BD; (2) clinically suggestive of myelopathy; (3) simultaneous spinal cord and brain magnetic resonance images (MRIs) within 1 month of acute worsening of myelopathy; and (4) follow-up duration ≥ 1 year after initial MRI evaluation. Patients not fulfilling all inclusion criteria and having MRIs with poor quality or missing sequences were excluded. Read More

    A double-blind, placebo-controlled study of rituximab in patients with stiff person syndrome.
    Ann Neurol 2017 Aug 9;82(2):271-277. Epub 2017 Aug 9.
    National Institute of Neurological Disorders and Stroke, Bethesda, MD (retired).
    Objective: In stiff person syndrome (SPS), an antibody-mediated impaired γ-aminobutyric acidergic (GABAergic) neurotransmission is believed to cause muscle stiffness and spasms. Most patients improve with GABA-enhancing drugs and intravenous immunoglobulin, but some respond poorly and remain disabled. The need for more effective therapy prompted a trial with the anti-CD20 monoclonal antibody rituximab. Read More

    Combined electroencephalography-functional magnetic resonance imaging and electrical source imaging improves localization of pediatric focal epilepsy.
    Ann Neurol 2017 Aug 9;82(2):278-287. Epub 2017 Aug 9.
    Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
    Objective: Surgical treatment in epilepsy is effective if the epileptogenic zone (EZ) can be correctly localized and characterized. Here we use simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) data to derive EEG-fMRI and electrical source imaging (ESI) maps. Their yield and their individual and combined ability to (1) localize the EZ and (2) predict seizure outcome were then evaluated. Read More

    Polygenic risk score analysis of pathologically confirmed Alzheimer disease.
    Ann Neurol 2017 Aug 9;82(2):311-314. Epub 2017 Aug 9.
    Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom.
    Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer disease have given area under the curve (AUC) estimates of <80%. However, these have been based on the genetic analysis of clinical case-control series. Here, we apply the same analytic approaches to a pathological case-control series and show a predictive AUC of 84%. Read More

    Multimodal image analysis of clinical influences on preterm brain development.
    Ann Neurol 2017 Aug 19;82(2):233-246. Epub 2017 Aug 19.
    Centre for the Developing Brain, King's College London, St Thomas' Hospital, London, United Kingdom.
    Objective: Premature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long-term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents. Read More

    Fibrin(ogen) and neurodegeneration in the progressive multiple sclerosis cortex.
    Ann Neurol 2017 Aug 19;82(2):259-270. Epub 2017 Aug 19.
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
    Objective: Neuronal loss, a key substrate of irreversible disability in multiple sclerosis (MS), is a recognized feature of MS cortical pathology of which the cause remains unknown. Fibrin(ogen) deposition is neurotoxic in animal models of MS, but has not been evaluated in human progressive MS cortex. The aim of this study was to investigate the extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relationship with neurodegeneration. Read More

    Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration.
    Ann Neurol 2017 Aug 19;82(2):247-258. Epub 2017 Aug 19.
    Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
    Objective: To test the hypotheses that (1) antemortem cerebrospinal fluid (CSF) tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration (FTLD) and (2) tauopathy patients have higher phosphorylated-tau levels compared to transactivation response element DNA-binding protein 43 (TDP-43) proteinopathy patients while accounting for Alzheimer's disease (AD) copathology.

    Methods: Patients had autopsy-confirmed FTLD with tauopathy (n = 31), TDP-43 proteinopathy (n = 49), or AD (n = 26) with antemortem CSF. CSF tau levels were compared between groups and correlated with digital histology measurement of postmortem tau pathology averaged from three cerebral regions (angular gyrus, mid-frontal cortex, and anterior cingulate gyrus). Read More

    Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.
    Ann Neurol 2017 Aug 29;82(2):208-222. Epub 2017 Jul 29.
    Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY.
    Objective: The brain blood vessels of patients with type 2 diabetes and dementia have deposition of amylin, an amyloidogenic hormone cosecreted with insulin. It is not known whether vascular amylin deposition is a consequence or a trigger of vascular injury. We tested the hypothesis that the vascular amylin deposits cause endothelial dysfunction and microvascular injury and are modulated by amylin transport in the brain via plasma apolipoproteins. Read More

    Neutrophil extracellular traps in ischemic stroke thrombi.
    Ann Neurol 2017 Aug 11;82(2):223-232. Epub 2017 Aug 11.
    Laboratory for Thrombosis Research, KU Leuven, Campus Kulak Kortrijk, Kortrijk, Belgium.
    Objective: Neutrophil extracellular traps (NETs) have been shown to promote thrombus formation. Little is known about the exact composition of thrombi that cause ischemic stroke. In particular, no information is yet available on the presence of NETs in cerebral occlusions. Read More

    Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, mortality, and treatment interactions.
    Ann Neurol 2017 Aug 19;82(2):196-207. Epub 2017 Jul 19.
    Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada.
    Objective: To characterize cerebral microbleeds (CMBs) in lacunar stroke patients in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial and to assess their relationship with recurrent stroke and death, and response to assigned treatment.

    Methods: SPS3 is a randomized, clinical trial conducted between 2003 and 2011. Patients with recent magnetic resonance imaging (MRI)-documented lacunar infarcts were randomly assigned in a factorial design to target levels of systolic blood pressure (130-149mmHg vs <130mmHg; open label) and to antiplatelet treatment (aspirin/clopidogrel vs aspirin/placebo; double-blinded). Read More

    Time-dependent risk of seizures in critically ill patients on continuous electroencephalogram.
    Ann Neurol 2017 Aug 19;82(2):177-185. Epub 2017 Jul 19.
    Department of Neurology, Free University of Brussels, Brussels, Belgium.
    Objective: Find the optimal continuous electroencephalographic (CEEG) monitoring duration for seizure detection in critically ill patients.

    Methods: We analyzed prospective data from 665 consecutive CEEGs, including clinical factors and time-to-event emergence of electroencephalographic (EEG) findings over 72 hours. Clinical factors were selected using logistic regression. Read More

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