11,557 results match your criteria Annals of neurology[Journal]


Intact Brain Network Function in an Unresponsive Patient with COVID-19.

Ann Neurol 2020 Jul 1. Epub 2020 Jul 1.

Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Many patients with severe coronavirus disease 2019 (COVID-19) remain unresponsive after surviving critical illness. Although several structural brain abnormalities have been described, their impact on brain function and implications for prognosis are unknown. Functional neuroimaging, which has prognostic significance, has yet to be explored in this population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25838DOI Listing

Spontaneous Multilevel Cerebrospinal Fluid Leak in Marfan Syndrome.

Ann Neurol 2020 Jul 1. Epub 2020 Jul 1.

Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Décarie; Montreal, PQ, H4A 3J1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25837DOI Listing

Synaptic loss in the multiple sclerosis spinal cord.

Ann Neurol 2020 Jun 30. Epub 2020 Jun 30.

Blizard Institute (Neuroscience, Surgery & Trauma), Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK.

Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area - a predictor of disability - is poor, questioning the unique role of axonal loss. We investigated the degree of synaptic loss in post-mortem spinal cords (18 chronic MS, eight healthy controls) using immunohistochemistry for synaptophysin and synapsin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25835DOI Listing

Validation of the neurogenic orthostatic hypotension ratio with active standing.

Ann Neurol 2020 Jun 28. Epub 2020 Jun 28.

Department of Neurology, Medical University of Innsbruck - Innsbruck, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25834DOI Listing

GlyR autoantibodies impair receptor function and induce motor dysfunction.

Ann Neurol 2020 Jun 26. Epub 2020 Jun 26.

Institute for Clinical Neurobiology, University Hospital, Julius-Maximilians-University of Würzburg, Germany.

Objective: Impairment of glycinergic neurotransmission leads to complex movement and behavioral disorders. Patients harboring glycine receptor autoantibodies suffer from stiff-person syndrome or its severe variant progressive encephalomyelitis with rigidity and myoclonus. Enhanced receptor internalization was proposed as the common molecular mechanism upon autoantibody binding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25832DOI Listing

Absence of subcerebral projection neurons is beneficial in a mouse model of ALS.

Ann Neurol 2020 Jun 26. Epub 2020 Jun 26.

Inserm UMR_S 1118, Mécanismes centraux et périphériques de la neurodégénérescence, Faculté de Médecine, Université de Strasbourg, Strasbourg, France.

Objective: Recent studies carried on amyotrophic lateral sclerosis patients suggest that the disease may initiate in the motor cortex and spread to its targets along the corticofugal tracts. In this study, we aimed at experimentally testing the corticofugal hypothesis of amyotrophic lateral sclerosis.

Methods: Sod1 and Fezf2 knockout mouse lines were crossed to generate a model that ubiquitously expresses a mutant of the murine Sod1 gene, a condition sufficient to induce progressive motor symptoms and premature death, but genetically lacks corticospinal neurons and other subcerebral projection neurons, one of the main populations of corticofugal neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25833DOI Listing

Anti-migraine CGRP receptor antagonists worsen cerebral ischemic outcome in mice.

Ann Neurol 2020 Jun 25. Epub 2020 Jun 25.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Objective: CGRP pathway inhibitors are emerging treatments for migraine. CGRP-mediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25831DOI Listing

NMDAr antibodies alter dopamine receptors and cause psychotic behavior in mice.

Ann Neurol 2020 Jun 25. Epub 2020 Jun 25.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Objective: To demonstrate that antibodies from patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis alter the levels of dopamine 1 receptor (D1R) and dopamine 2 receptor (D2R) and cause psychotic-like features in mice.

Methods: Cultured rat hippocampal neurons were treated with cerebrospinal fluid (CSF) from patients with anti-NMDAR encephalitis or controls, and the effects on clusters of D1R and D2R were quantified. In vivo studies included 71 C57BL/6J mice that were chronically infused with patients' or controls' CSF through ventricular catheters connected to subcutaneous osmotic pumps. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25829DOI Listing

Multidisciplinary guidance to manage comatose patients with severe COVID-19.

Ann Neurol 2020 Jun 25. Epub 2020 Jun 25.

Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25830DOI Listing

Corrigendum: Depression as a Risk Factor for Impulse Control Disorders in Parkinson Disease.

Ann Neurol 2020 07 27;88(1):205. Epub 2020 Apr 27.

Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25722DOI Listing

Development and validation of forecasting next reported seizure using e-diaries.

Ann Neurol 2020 Jun 22. Epub 2020 Jun 22.

Harvard Medical School.

Objective: There are no validated methods for predicting the timing of seizures. Using machine learning, we sought to forecast 24-hour risk of self-reported seizure from e-diaries.

Methods: Data from 5,419 patients of SeizureTracker. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25812DOI Listing

Haploinsufficiency of Cyfip2 Causes Lithium-Responsive Prefrontal Dysfunction.

Ann Neurol 2020 Jun 20. Epub 2020 Jun 20.

Department of Neuroscience, College of Medicine, Korea University, Seoul, South Korea.

Objective: Genetic variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) encoding an actin-regulatory protein are associated with brain disorders, including intellectual disability and epilepsy. However, specific in vivo neuronal defects and potential treatments for CYFIP2-associated brain disorders remain largely unknown. Here, we characterized Cyfip2 heterozygous (Cyfip2 ) mice to understand their neurobehavioral phenotypes and underlying pathological mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25827DOI Listing
June 2020
9.977 Impact Factor

Brain insulin signaling, Alzheimer's disease pathology, and cognitive function.

Ann Neurol 2020 Jun 18. Epub 2020 Jun 18.

Department of Neurology and the Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts, 02129, USA.

Objective: To examine associations of molecular markers of brain insulin signaling with Alzheimer's disease (AD) and cognition, among older persons with or without diabetes.

Methods: This clinical-pathologic study was derived from a community-based cohort study, the Religious Orders Study. We studied 150 individuals (mean age-at-death =87 years, 48% women): 75 with and 75 without diabetes (matched by sex on age-at-death and education). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25826DOI Listing

Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies.

Ann Neurol 2020 Jun 18. Epub 2020 Jun 18.

Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.

Objective: To explore the role of alpha-synuclein (αSyn) oligomers and neurofilament light chain (NFL) in cerebrospinal fluid (CSF) as markers of early multiple system atrophy (MSA) and to contrast findings to Lewy body synucleinopathies.

Methods: In a discovery cohort of well-characterized early MSA patients (n = 24) and matched healthy controls (CON, n = 14) we utilized ELISA to measure NFL and protein misfolding cyclic amplification (PMCA) to detect αSyn oligomers in CSF. We confirmed findings in a separate prospectively enrolled cohort of patients with early MSA (n = 38), Parkinson's disease (PD, n = 16), dementia with Lewy bodies (DLB, n = 13), and CON subjects (n = 15). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25824DOI Listing

Classification of Facial Expressions for Intended Display of Emotions Using Brain-Computer Interfaces.

Ann Neurol 2020 Jun 17. Epub 2020 Jun 17.

UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Facial expressions are important for intentional display of emotions in social interaction. For people with severe paralysis, the ability to display emotions intentionally can be impaired. Current brain-computer interfaces (BCIs) allow for linguistic communication but are cumbersome for expressing emotions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25821DOI Listing

Vision therapy: ocular motor training in mild traumatic brain injury.

Ann Neurol 2020 Jun 15. Epub 2020 Jun 15.

Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Oto-laryngology, University of Toronto, Toronto, Canada.

Vision therapy in the form of ocular motor training is increasingly used to treat visual complaints, particularly in the setting of persistent symptoms after mild traumatic brain injury (mTBI). In this review we discuss the rationale behind this intervention and the evidence for its efficacy. While the efficacy of exercises for primary convergence insufficiency is plausible and supported by data, there is not yet strong evidence of benefit for the post-traumatic variant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25820DOI Listing

Evolution of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Early Parkinson's Disease.

Ann Neurol 2020 Jun 16. Epub 2020 Jun 16.

Department of Pathology and Laboratory Medicine, School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Objective: We analyzed the longitudinal profile of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers in early Parkinson's disease (PD) compared with healthy controls (HCs) and tested baseline CSF biomarkers for prediction of clinical decline in PD.

Methods: Amyloid-β 1 to 42 (Aβ ), total tau (t-tau) and phosphorylated tau (p-tau) at the threonine 181 position were measured using the high-precision Roche Elecsys electrochemiluminescence immunoassay in all available CSF samples from longitudinally studied patients with PD (n = 416) and HCs (n = 192) followed for up to 3 years in the Parkinson's Progression Markers Initiative (PPMI). Longitudinal CSF and clinical data were analyzed with linear-mixed effects models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25811DOI Listing

Invited Commentary: The role of temporal sequence in treating intracerebral hemorrhage.

Ann Neurol 2020 Jun 15. Epub 2020 Jun 15.

Division of Brain Injury Outcomes, Johns Hopkins University, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25823DOI Listing

Drug-responsive inhomogeneous cortical modulation by direct current stimulation.

Ann Neurol 2020 Jun 15. Epub 2020 Jun 15.

Department of Neurology and the F.M. Kirby Neurobiology Center, Harvard Medical School, Boston, MA, 02115, USA.

Objective: Cathodal direct current stimulation (cDCS) induces long-term depression (LTD)-like reduction of cortical excitability (DCS-LTD), which has been tested in the treatment of epilepsy with modest effects. In part, this may be due to variable cortical neuron orientation relative to the electric field. We tested, in vivo and in vitro, whether DCS-LTD occurs throughout the cortical thickness, and if not, then whether drug-DCS pairing can enhance the uniformity of the cortical response and the cDCS antiepileptic effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25822DOI Listing

GGC Repeat Expansion in NOTCH2NLC is rare in European Leukoencephalopathy.

Ann Neurol 2020 Jun 15. Epub 2020 Jun 15.

Department of Neuromuscular Diseases, Institute of Neurology, University College, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25818DOI Listing

Mapping the insula with stereo-electroencephalography: The emergence of semiology in insula lobe seizures.

Ann Neurol 2020 Jun 15. Epub 2020 Jun 15.

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, GIN, 38000, Grenoble, France.

Objective: Insula epilepsy is rare and can be evaluated effectively by Stereotactic intracerebral EEG (SEEG). Many previous studies of insulo-opercular seizures have been unable to separate insular and opercular onset. With adequate sampling of the insula, this study shows this is possible. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25817DOI Listing

Report of EEG Finding on Critically Ill Patients with COVID-19.

Ann Neurol 2020 Jun 13. Epub 2020 Jun 13.

Bioserenity Inc, Atlanta, USA.

In March 2020, we treated a cohort of 26 critically ill hospitalized SARS-CoV-2 infected patients who received EEGs to assess unexplained altered mental status, loss of consciousness, or poor arousal and responsiveness. Of the 26 patients studied, 5 patients had EEGs that showed Periodic Discharges (PD) consisting of high amplitude frontal monomorphic delta waves with absence of epileptic activity. These findings may suggest CNS injury potentially related to COVID-19 in these patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323170PMC

Association Between Pregnancy and Cervical Artery Dissection.

Ann Neurol 2020 Jun 11. Epub 2020 Jun 11.

Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York.

Objective: To determine whether pregnancy is associated with cervical artery dissection.

Methods: We performed a case-control study using claims data from all nonfederal emergency departments and acute care hospitals in New York and Florida between 2005-2015. Cases were women 12-42 years of age hospitalized with cervical artery dissection, defined using validated diagnosis codes for carotid/vertebral artery dissection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25813DOI Listing

SCN3A-related neurodevelopmental disorder: A spectrum of epilepsy and brain malformation.

Ann Neurol 2020 Jun 8. Epub 2020 Jun 8.

Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: Pathogenic variants in SCN3A, encoding the voltage-gated sodium channel subunit Nav1.3, cause severe childhood-onset epilepsy and malformation of cortical development. Here, we define the spectrum of clinical, genetic, and neuroimaging features of SCN3A-related neurodevelopmental disorder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25809DOI Listing

Identifying Progression In Multiple Sclerosis: New Perspectives.

Ann Neurol 2020 Jun 7. Epub 2020 Jun 7.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

The identification of progression in multiple sclerosis is typically retrospective. Given the profound burden of progressive multiple sclerosis, and the recent development of effective treatments for these patients, there is a need to establish measures capable of identifying progressive multiple sclerosis early in the disease course. Starting from recent pathological findings, this review assesses the state-of-the-art of potential measures able to predict progressive multiple sclerosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25808DOI Listing

COVID-19: A Global Threat to the Nervous System.

Ann Neurol 2020 07;88(1):1-11

Department of Neurology, Medicine, and Immunology-Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.

In less than 6 months, the severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now understand that coronavirus disease 2019 (COVID-19) also involves multiple other organs, including the central and peripheral nervous system. The number of recognized neurologic manifestations of SARS-CoV-2 infection is rapidly accumulating. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300753PMC

Radiologically Isolated Syndrome: 10-Year Risk Estimate of a Clinical Event.

Ann Neurol 2020 Jun 4. Epub 2020 Jun 4.

University of Texas Southwestern Medical Center, Dallas, TX, USA.

Objective: We have previously identified male sex, younger age, and the presence of spinal cord lesions as independent factors that increase the 5-year risk for evolution from radiologically isolated syndrome (RIS) to multiple sclerosis. Here, we investigate risk factors for the development of a clinical event using a 10-year, multinational, retrospectively identified RIS dataset.

Methods: RIS subjects were identified according to 2009 RIS criteria and followed longitudinally as part of a worldwide cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25799DOI Listing

Reader Response: Comparison of the Response to Rituximab between Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibody Diseases.

Ann Neurol 2020 Jun 4. Epub 2020 Jun 4.

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25805DOI Listing

3D DWI With Cinematic Rendering for Epidermoid Cyst.

Ann Neurol 2020 Jun 4. Epub 2020 Jun 4.

University Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25810DOI Listing
June 2020
9.977 Impact Factor

MRI in Neuromuscular Diseases: An Emerging Diagnostic Tool and Biomarker for Prognosis and Efficacy.

Ann Neurol 2020 Jun 4. Epub 2020 Jun 4.

Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.

There is an unmet need to identify biomarkers sensitive to change in rare, slowly progressive neuromuscular diseases. Quantitative magnetic resonance imaging (MRI) of muscle may offer this opportunity, as it is noninvasive and can be carried out almost independent of patient cooperation and disease severity. Muscle fat content correlates with muscle function in neuromuscular diseases, and changes in fat content precede changes in function, which suggests that muscle MRI is a strong biomarker candidate to predict prognosis and treatment efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25804DOI Listing

NOTCH2NLC GGC repeat expansions are associated with sporadic essential tremor: Variable disease expressivity on long-term follow-up.

Ann Neurol 2020 Jun 4. Epub 2020 Jun 4.

Neuroscience and Behavioural Disorders, Duke NUS Medical School, Singapore.

We screened 662 subjects comprising 462 essential tremor, ET (285 sporadic, 125 with family history and 52 probands from well-characterized ET pedigrees and 200 controls and identified pathogenic NOTCH2NLC GGC repeat expansions in four sporadic ET patients. Two patients were followed up for over a decade: one with 90 repeats remained an ET phenotype that did not evolve after forty years, while another patient with 107 repeats developed motor symptoms and cognitive impairment after 8 to 10years. Neuroimaging in this patient revealed severe leukoencephalopathy; diffusion-weighted imaging hyperintensity in the corticomedullary junction and skin biopsy revealed intranuclear inclusions suggestive of intranuclear inclusion body disease (NIID). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25803DOI Listing
June 2020
9.977 Impact Factor

Vertebral Artery Fenestration Mimicking Acute Dissection.

Ann Neurol 2020 Jun 1. Epub 2020 Jun 1.

Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25800DOI Listing

Characterization of recessive Parkinson's disease in a large multicenter study.

Ann Neurol 2020 May 30. Epub 2020 May 30.

Research Unit UMR_1127 at Sorbonne Université, Paris, France.

Studies of the phenotype and population distribution of rare genetic forms of parkinsonism are required, now that gene-targeting approaches for Parkinson's disease have reached the clinical trial stage. We evaluated the frequencies of PRKN, PINK1, and DJ-1 mutations in a cohort of 1587 cases. Mutations were found in 14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25787DOI Listing

Comparison of Core Features in Four Developmental Encephalopathies in the Rett Natural History Study.

Ann Neurol 2020 May 30. Epub 2020 May 30.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Objective: Rett syndrome, CDKL5-deficiency disorder, FOXG1 disorder, and MECP2 duplication disorder are developmental encephalopathies with shared and distinct features. Although they are historically linked, no direct comparison has been performed. The first head-to-head comparison of clinical features in these conditions is presented. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25797DOI Listing

Nilotinib Effects on Safety, Tolerability, and Biomarkers in Alzheimer's Disease.

Ann Neurol 2020 Jul 28;88(1):183-194. Epub 2020 May 28.

Translational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.

Objective: Preclinical evidence with nilotinib, a US Food and Drug Administration (FDA)-approved drug for leukemia, indicates improvement in Alzheimer's disease phenotypes. We investigated whether nilotinib is safe, and detectable in cerebrospinal fluid, and alters biomarkers and clinical decline in Alzheimer's disease.

Methods: This single-center, phase 2, randomized, double-blind, placebo-controlled study investigated the safety, tolerability, and pharmacokinetics of nilotinib, and measured biomarkers in participants with mild to moderate dementia due to Alzheimer's disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25775DOI Listing

Is RBD a risk factor for impulse control disorder in Parkinson's disease?

Ann Neurol 2020 May 28. Epub 2020 May 28.

Neurology Department, CHU, Clermont-Ferrand, France.

Objective: To assess the association between REM sleep behavior disorder (RBD) and other determinants and incident impulse control disorder behaviors (ICBs) in patients with early Parkinson's disease (PD) using longitudinal data from the Parkinson's Progression Markers Initiative (PPMI).

Methods: 401 newly-diagnosed PD patients were prospectively evaluated at baseline (BL), month 6, and annually for 5 years. Probable RBD (pRBD) was assessed with the RBD Screening Questionnaire and dichotomized using a cut-off value ≥6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25798DOI Listing

Ultra-Early Blood Pressure Reduction Attenuates Hematoma Growth and Improves Outcome in Intracerebral Hemorrhage.

Ann Neurol 2020 May 26. Epub 2020 May 26.

Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Objective: The aim was to investigate whether intensive blood pressure treatment is associated with less hematoma growth and better outcome in intracerebral hemorrhage (ICH) patients who received intravenous nicardipine treatment ≤2 hours after onset of symptoms.

Methods: A post-hoc exploratory analysis of the Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 (ATACH-2) trial was performed. This was a multicenter, international, open-label, randomized clinical trial, in which patients with primary ICH were allocated to intensive versus standard blood pressure treatment with nicardipine ≤4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25793DOI Listing
May 2020
9.977 Impact Factor

A Young Generalized Dystonia Patient with Globus-Pallidus-Specific Lesion.

Ann Neurol 2020 May 26. Epub 2020 May 26.

Department of Neurosurgery, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25791DOI Listing

Persistent Hypoglossal Artery and Concurrent Carotid Thrombus.

Ann Neurol 2020 May 24. Epub 2020 May 24.

Department of Neurology, University of Cincinnati, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25795DOI Listing

Conditioning Electrical Stimulation Accelerates Regeneration in Nerve Transfers.

Ann Neurol 2020 May 24. Epub 2020 May 24.

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

Objective: Compared to the upper limb, lower limb distal nerve transfer (DNT) outcomes are poor, likely due to the longer length of regeneration required. DNT surgery to treat foot drop entails rerouting a tibial nerve branch to the denervated common fibular nerve stump to reinnervate the tibialis anterior muscle for ankle dorsiflexion. Conditioning electrical stimulation (CES) prior to nerve repair surgery accelerates nerve regeneration and promotes sensorimotor recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25796DOI Listing

Pediatric Leigh Syndrome: Neuroimaging Features and Genetic Correlations.

Ann Neurol 2020 May 22. Epub 2020 May 22.

Division of Neuroradiology, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

The neurodiagnostic criteria of Leigh syndrome have not yet been clearly redefined based on the expanding of molecular etiologies. We aimed to analyze 20 years of clinical, genetic, and magnetic resonance studies from our Leigh syndrome cohort to provide a detailed description of central nervous system lesions in Leigh syndrome and their biological evolution in view of their genetic and clinical findings. Our study adds new neurodiagnostic insights to the current knowledge of Leigh syndrome, including association with overlapping syndromes, and the correlation of pathogenic genetic variants with neuroimaging phenotypes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25789DOI Listing

Reply to "CDR2 and CDR2L Yo Antigens in Paraneoplastic Cerebellar Degeneration".

Ann Neurol 2020 May 22. Epub 2020 May 22.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25794DOI Listing

CDR2 and CDR2L Yo Antigens in Paraneoplastic Cerebellar Degeneration.

Ann Neurol 2020 May 22. Epub 2020 May 22.

Geriatric Research, Education, and Clinical Center, VA Salt Lake Health Care System, Salt Lake City, Utah, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25790DOI Listing

Gut Microbiome Signatures of Risk and Prodromal Markers of Parkinson Disease.

Ann Neurol 2020 May 22. Epub 2020 May 22.

Department of Neurology, Helsinki University Hospital and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.

Objective: Alterations of the gut microbiome in Parkinson disease (PD) have been repeatedly demonstrated. However, little is known about whether such alterations precede disease onset and how they relate to risk and prodromal markers of PD. We investigated associations of these features with gut microbiome composition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25788DOI Listing

Correction.

Authors:

Ann Neurol 2020 Jun 25;87(6):991-992. Epub 2020 Apr 25.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25727DOI Listing

Longitudinal Development of Peripapillary Hyper-Reflective Ovoid Masslike Structures Suggests a Novel Pathological Pathway in Multiple Sclerosis.

Ann Neurol 2020 May 19. Epub 2020 May 19.

Optometry and Visual Sciences, City, University of London, London, United Kingdom.

Objective: Peripapillary hyper-reflective ovoid masslike structures (PHOMS) are a new spectral domain optical coherence tomography (OCT) finding.

Methods: This prospective, longitudinal study included patients (n = 212) with multiple sclerosis (MS; n = 418 eyes), 59 healthy controls (HCs; n = 117 eyes), and 267 non-MS disease controls (534 eyes). OCT and diffusion tensor imaging were used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25782DOI Listing

Epileptic Activity Intrinsically Generated in the Human Cerebellum.

Ann Neurol 2020 May 18. Epub 2020 May 18.

Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Boston, MA, USA.

Neoplastic or dysplastic neuronal tissue in the brain stem and cerebellum can become epileptogenic in pediatric patients. However, it is unknown whether such tissue may transform intrinsic properties of the human cerebellum, making it capable of generating epileptic population activity. We noninvasively detected epileptiform signals unaveraged in a pediatric patient with epilepsy due to a tumor in the middle cerebellar peduncle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.25779DOI Listing