932 results match your criteria Annals of laboratory medicine[Journal]


Late Diagnosis of Wilson Disease, Initially Presenting as Cerebellar Atrophy Mimicking Spinocerebellar Ataxia, by Multigene Panel Testing.

Ann Lab Med 2020 11 17;40(6):500-503. Epub 2020 Jun 17.

Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.6.500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295955PMC
November 2020

Quality of Ribonucleic Acid Extraction for Real-Time Reverse Transcription-PCR (rRT-PCR) of SARS-CoV-2: Importance of Internal Control Monitoring.

Ann Lab Med 2020 11 17;40(6):490-492. Epub 2020 Jun 17.

Department of Laboratory Medicine, University of Ulsan, College of Medicine and Asan Medical Center, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.6.490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295956PMC
November 2020

Clinical Features and Risk Factors Associated With 30-Day Mortality in Patients With Pneumonia Caused by Hypervirulent Klebsiella pneumoniae (hvKP).

Ann Lab Med 2020 11 17;40(6):481-487. Epub 2020 Jun 17.

Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.

Background: Reports on metastatic or invasive infections by hypervirulent Klebsiella pneumoniae (hvKP) have increased recently. However, the effects of its virulence on clinical course and outcomes in pneumonia patients have rarely been addressed. We assessed and compared the clinical features of hvKp and classic K. Read More

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http://dx.doi.org/10.3343/alm.2020.40.6.481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295963PMC
November 2020

Absolute Change in High-Sensitivity Cardiac Troponin I at Three Hours After Presentation is Useful for Diagnosing Acute Myocardial Infarction in the Emergency Department.

Ann Lab Med 2020 11 17;40(6):474-480. Epub 2020 Jun 17.

Division of Cardiology, Department of Internal Medicine, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, Korea.

Background: A rise and/or fall in cardiac troponin value with at least one value above the 99th percentile upper reference limit is essential for acute myocardial infarction (AMI) diagnosis. We evaluated the clinical usefulness of serial high-sensitivity cardiac troponin I (hs-cTnI) measurements in AMI diagnosis, in terms of the predictability of absolute and relative changes.

Methods: For this retrospective, forward observational study, we enrolled 281 patients older than 18 years who presented with chest pain at the emergency department (ED) between August 2015 and December 2016. Read More

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http://dx.doi.org/10.3343/alm.2020.40.6.474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295960PMC
November 2020

Proenkephalin Predicts Organ Failure, Renal Replacement Therapy, and Mortality in Patients With Sepsis.

Ann Lab Med 2020 11 17;40(6):466-473. Epub 2020 Jun 17.

Department of Medical-Surgery Sciences and Translational Medicine, School of Medicine and Psychology, Sapienza-University, Sant' Andrea Hospital, Rome, Italy.

Background: Kidney failure occurs frequently and is associated with high mortality during sepsis. Proenkephalin (PENK) is an emerging biomarker of kidney function. We explored whether PENK levels could predict severity, organ failure, and mortality in septic patients. Read More

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http://dx.doi.org/10.3343/alm.2020.40.6.466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295958PMC
November 2020

Exploration and Validation of the Performance of Hemoglobin A1c in Detecting Diabetes in Community-Dwellers With Hypertension.

Ann Lab Med 2020 11 17;40(6):457-465. Epub 2020 Jun 17.

Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China.

Background: Diabetes can complicate hypertension management by increasing the risk of cardiovascular disease (CVD) and all-cause mortality. Studies targeting diabetes detection in hypertensive individuals demonstrating an increased risk of diabetes are lacking. We aimed to assess the performance of hemoglobin A1c (HbA1c) and its cut-off point in detecting diabetes in the abovementioned population. Read More

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http://dx.doi.org/10.3343/alm.2020.40.6.457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295957PMC
November 2020

Stability of pH, Blood Gas Partial Pressure, Hemoglobin Oxygen Saturation Fraction, and Lactate Concentration.

Ann Lab Med 2020 11 17;40(6):448-456. Epub 2020 Jun 17.

Laboratori Clínic Territorial Metropolitana Sud-Hospital Universitari de Bellvitge. Hospitalet de Llobregat, Barcelona, Spain.

Background: The storage temperature and time of blood gas samples collected in syringes constitute preanalytical variables that could affect blood gas or lactate concentration measurement results. We analyzed the effect of storage temperature and time delay on arterial or venous blood gas stability related to pH, partial pressure of carbon dioxide (pCO2) and oxygen (pO2), hemoglobin oxygen saturation (sO2), and lactate concentration.

Methods: In total, 1,200 arterial and venous blood sample syringes were analyzed within 10 minutes of collection. Read More

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http://dx.doi.org/10.3343/alm.2020.40.6.448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295962PMC
November 2020

COVID-19 Molecular Testing in Korea: Practical Essentials and Answers From Experts Based on Experiences of Emergency Use Authorization Assays.

Ann Lab Med 2020 11 17;40(6):439-447. Epub 2020 Jun 17.

Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Osong, Korea.

Coronavirus disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early detection of COVID-19 and immediate isolation of infected patients from the naive population are important to prevent further pandemic spread of the infection. Real-time reverse transcription (RT)-PCR to detect SARS-CoV-2 RNA is currently the most reliable diagnostic method for confirming COVID-19 worldwide. Read More

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http://dx.doi.org/10.3343/alm.2020.40.6.439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295959PMC
November 2020

The First Korean Case of De Novo Proximal 4p Deletion Syndrome in a Child With Developmental Delay.

Ann Lab Med 2020 Sep;40(5):435-437

Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.5.435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169634PMC
September 2020

False Positive Class II HLA Antibody Reaction Due to Antibodies Against Denatured HLA Might Differ Between Assays: One Lambda vs. Immucor.

Ann Lab Med 2020 Sep;40(5):424-427

Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.5.424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169623PMC
September 2020

First Case of Bacteremia Caused by Coprobacillus catenaformis.

Ann Lab Med 2020 Sep;40(5):421-423

Department of Laboratory Medicine and Genetics, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.5.421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169632PMC
September 2020

Bone Marrow Gouty Tophi With Plasma Cell Myeloma.

Ann Lab Med 2020 Sep;40(5):414-416

Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.5.414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169628PMC
September 2020

Prevalence and Immunophenotypic Characteristics of Monoclonal B-Cell Lymphocytosis in Healthy Korean Individuals With Lymphocytosis.

Ann Lab Med 2020 09;40(5):409-413

Department of Laboratory Medicine and Genetics, Sungkyunkwan University School of Medicine, Seoul, Korea.

Epidemiological studies of monoclonal B-cell lymphocytosis (MBL) have been conducted in limited geographical regions. Little is known about the prevalence of MBL in Asia. We investigated the prevalence and immunophenotypic characteristics of MBL in Koreans who had idiopathic lymphocytosis (lymphocyte count >4. Read More

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http://dx.doi.org/10.3343/alm.2020.40.5.409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169624PMC
September 2020
1.481 Impact Factor

Pre-Transplant Angiotensin II Type 1 Receptor Antibodies and Anti-Endothelial Cell Antibodies Predict Graft Function and Allograft Rejection in a Low-Risk Kidney Transplantation Setting.

Ann Lab Med 2020 09;40(5):398-408

Department of Laboratory Medicine and Genetics, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Non-HLA antibodies, anti-angiotensin II type 1 receptor antibodies (anti-AT1R) and anti-endothelial cell antibodies (AECA), are known to play a role in allograft rejection. We evaluated the role of both antibodies in predicting post-transplant outcomes in low-risk living donor kidney transplantation (LDKT) recipients.

Methods: In 94 consecutive LDKT recipients who were ABO compatible and negative for pre-transplant HLA donor-specific antibodies, we determined the levels of anti-AT1Rs using an enzyme-linked immunosorbent assay and the presence of AECAs using a flow cytometric endothelial cell crossmatch (ECXM) assay with pre-transplant sera. Read More

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http://dx.doi.org/10.3343/alm.2020.40.5.398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169631PMC
September 2020

Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis.

Ann Lab Med 2020 09;40(5):390-397

Department of Biotechnology, National Institute of Technology, Yupia, Papum Pare, Arunachal Pradesh, India.

Background: The effect of the interplay among inflammation, angiogenesis, extracellular matrix (ECM) degradation, and oxidative stress (OS) on the pathogenesis of endometriosis remains unclear. Previously, we demonstrated the role of OS in endometriosis. Here, we performed a comprehensive investigation of several molecules involved in inflammation, angiogenesis, and ECM degradation in women with endometriosis to study their interplay with OS. Read More

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http://dx.doi.org/10.3343/alm.2020.40.5.390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169633PMC
September 2020
1.481 Impact Factor

Specific IgG and IgA Antibody Reactivities in Sera of Children by Enzyme-Linked Immunoassay and Comparison With Giardia duodenalis Diagnosis in Feces.

Ann Lab Med 2020 09;40(5):382-389

Department of Clinical and Toxicological Analysis, Pharmacy College, Salvador, Brazil.

Background: Giardia duodenalis is conventionally diagnosed in fecal samples using parasitological methods. However, sensitivity is poor when only a single sample is analyzed, due to intermittent excretion of cysts in feces. Alternatively, the serum antibodies to G. Read More

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http://dx.doi.org/10.3343/alm.2020.40.5.382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169635PMC
September 2020
1.481 Impact Factor

Clonal Distribution of Clindamycin-Resistant Erythromycin-Susceptible (CRES) Streptococcus agalactiae in Korea Based on Whole Genome Sequences.

Ann Lab Med 2020 09;40(5):370-381

Department of Laboratory Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea.

Background: The clindamycin-resistant erythromycin-susceptible (CRES) phenotype is rare in Streptococcus agalactiae (group B streptococci). We aimed to determine the molecular characteristics of CRES S. agalactiae using whole genome sequencing (WGS). Read More

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http://dx.doi.org/10.3343/alm.2020.40.5.370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169627PMC
September 2020

Diagnostic Approach for Double-Hit and Triple-Hit Lymphoma Based on Immunophenotypic and Cytogenetic Characteristics of Bone Marrow Specimens.

Ann Lab Med 2020 09;40(5):361-369

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: High-grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6 (BCL2/BCL6), also known as double-hit lymphoma (DHL) and/or triple-hit lymphoma (THL), is a new entity of B-cell lymphoma in the 2017 WHO Classification. We retrospectively investigated D/THL and their clinico-laboratory features among cases of large B-cell lymphoma involving the bone marrow (BM), including diffuse large B-cell lymphoma, Burkitt lymphoma, and B-cell lymphomas with medium to large lymphoid cells, by additional FISH analysis of BM aspirates.

Methods: A total of 111 patients diagnosed with aggressive B-cell lymphomas or B-cell lymphoma involving the BM with medium to large-sized malignant lymphocytes were reviewed from January 2000 to January 2018. Read More

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http://dx.doi.org/10.3343/alm.2020.40.5.361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169621PMC
September 2020

Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea.

Ann Lab Med 2020 09;40(5):351-360

Center for Laboratory Control of Infectious Diseases, Centers for Disease Control and Prevention, Osong, Korea.

The outbreak of coronavirus disease 2019 (COVID-19), which began in December 2019, is still ongoing in Korea, with >9,000 confirmed cases as of March 25, 2020. COVID-19 is a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, and real-time reverse transcription-PCR is currently the most reliable diagnostic method for COVID-19 around the world. Korean Society for Laboratory Medicine and the Korea Centers for Disease Prevention and Control propose guidelines for diagnosing COVID-19 in clinical laboratories in Korea. Read More

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http://dx.doi.org/10.3343/alm.2020.40.5.351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169629PMC
September 2020

COVID-19 Testing in South Korea: Current Status and the Need for Faster Diagnostics.

Ann Lab Med 2020 Sep 31;40(5):349-350. Epub 2020 Mar 31.

Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.5.349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169622PMC
September 2020

Identification of a Novel Splice Variant (c.423-8A>G) of by RNA Sequencing.

Ann Lab Med 2020 Jul;40(4):345-347

Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.4.345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054688PMC

Thrombocythemia 1 With Variant (c.13+1G>A) Diagnosed Using Targeted Exome Sequencing: First Case in Korea.

Ann Lab Med 2020 Jul;40(4):341-344

Department of Pediatrics, Keimyung University School of Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.4.341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054690PMC

First Korean Case of Partial D .

Ann Lab Med 2020 Jul;40(4):337-340

Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.4.337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054695PMC

Isolation of Non-Hydrogen Sulfide-Producing Serovar Infantis from a Clinical Sample: the First Case in Korea.

Ann Lab Med 2020 Jul;40(4):334-336

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.4.334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054696PMC

The First Case of Bacteremia in Korea.

Ann Lab Med 2020 Jul;40(4):331-333

Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.4.331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054698PMC

Carrier Frequency of Spinal Muscular Atrophy in a Large-scale Korean Population.

Ann Lab Med 2020 Jul;40(4):326-330

GC Genome, Yongin, Korea.

Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by progressive proximal muscle weakness and atrophy. Given the recent introduction of gene therapies, knowledge of the SMA carrier frequency in various populations has become important for developing screening programs for this disease. In total, 1,581 anonymous DNA samples from an umbilical cord blood bank were tested for and gene copies using a multiplex ligation-dependent probe amplification assay. Read More

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http://dx.doi.org/10.3343/alm.2020.40.4.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054693PMC

Emergence of -Mediated Linezolid-Nonsusceptible in a Tertiary Care Hospital.

Ann Lab Med 2020 Jul;40(4):321-325

Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.

This study investigated resistance mechanisms and epidemiology of emerging linezolid-nonsusceptible (LNSEF) in a tertiary care hospital. LNSEF isolated from clinical samples were collected from November 2017 to June 2019. The isolates were investigated for linezolid resistance and the associated molecular mechanisms, including mutations of 23S rRNA domain V and acquisition of the or resistance gene. Read More

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http://dx.doi.org/10.3343/alm.2020.40.4.321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054691PMC

Comparison Between the SFTS-QS Kit and the PowerChek SFTSV Real-time PCR Kit for the Detection of Severe Fever With Thrombocytopenia Syndrome Virus.

Ann Lab Med 2020 Jul;40(4):317-320

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The recent increase in severe fever with thrombocytopenia syndrome (SFTS) cases has led to the development of the SFTS-QS kit (MiCoBioMed, Seongnam, Korea) for detecting the SFTS virus (SFTSV, now renamed ). SFTS-QS is a qualitative real-time reverse transcription PCR assay based on lab-on-a-chip technology. We evaluated the performance of the SFTS-QS kit and compared it with that of the PowerChek SFTSV Real-time PCR kit (PowerChek; Kogene Biotech, Seoul, Korea). Read More

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http://dx.doi.org/10.3343/alm.2020.40.4.317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054697PMC

Development of an Automated Image Analyzer for Microvessel Density Measurement in Bone Marrow Biopsies.

Ann Lab Med 2020 Jul;40(4):312-316

Department of Laboratory Medicine, Center for Diagnostic Oncology, Hospital and Research Institute, National Cancer Center, Goyang, Korea.

Angiogenesis is important for the proliferation and survival of multiple myeloma (MM) cells. Bone marrow (BM) microvessel density (MVD) is a useful marker of angiogenesis and an increase in MVD can be used as a marker of poor prognosis in MM patients. We developed an automated image analyzer to assess MVD from images of BM biopsies stained with anti-CD34 antibodies using two color models. Read More

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http://dx.doi.org/10.3343/alm.2020.40.4.312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054689PMC

Determination of Colistin Resistance by Simple Disk Diffusion Test Using Modified Mueller-Hinton Agar.

Ann Lab Med 2020 Jul;40(4):306-311

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.

Background: Colistin has become a last-resort antibiotic for the management of multidrug-resistant gram-negative bacteria. The disk diffusion test is cheap and easy to perform but may be unreliable for colistin susceptibility testing due to poor diffusion of the large colistin molecule. An improved agar diffusion test would increase the reliability of colistin susceptibility testing. Read More

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http://dx.doi.org/10.3343/alm.2020.40.4.306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054692PMC

HDL Subclass Analysis in Predicting Metabolic Syndrome in Koreans With High HDL Cholesterol Levels.

Ann Lab Med 2020 Jul;40(4):297-305

Department of Medical-Surgery Sciences and Translational Medicine, University La Sapienza Rome, Sant'Andrea Hospital, Rome, Italy.

Background: High-density lipoprotein cholesterol (HDL-C) is a complex mixture of subclasses with heterogeneous atheroprotective activities. We analyzed HDL-C subclass in relation to cardiovascular risk and metabolic syndrome (MetS) in a population with high HDL-C levels.

Methods: A total of 300 Korean individuals with high HDL-C levels (≥2. Read More

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http://dx.doi.org/10.3343/alm.2020.40.4.297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054694PMC

Cortisol Measurements in Cushing's Syndrome: Immunoassay or Mass Spectrometry?

Ann Lab Med 2020 Jul;40(4):285-296

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Determination of cortisol levels in the urine (24 hours urine free cortisol), saliva (late-night), or serum (total cortisol after dexamethasone suppression) is recommended to screen for Cushing's syndrome (CS). This review focuses on the differences between the frequently used cortisol-antibody immunoassay-based methods and the highly specific mass-spectrometry-based methods that are progressively being employed in clinical laboratories for CS screening. The particular characteristics of cortisol metabolism and the lack of specificity of the immunoassays cause marked differences between both methods that are in turn highly dependent on the biological matrix, in which the cortisol is measured. Read More

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http://dx.doi.org/10.3343/alm.2020.40.4.285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054699PMC

Genetic Spectrum of in Korean Patients with Unconjugated Hyperbilirubinemia.

Ann Lab Med 2020 May;40(3):281-283

Department of Laboratory Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.3.281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933057PMC

Pure Trisomy 20p: Report of a Novel Case of a Marker Chromosome and Literature Review.

Ann Lab Med 2020 May;40(3):277-280

Department of Laboratory Medicine, Korea University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.3.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933058PMC

Comparison of Biotin Interference in Second- and Third-Generation Roche Free Thyroxine Immunoassays.

Ann Lab Med 2020 May;40(3):274-276

Department of Laboratory Medicine, College of Medicine Korea University, Seoul, Korea.

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http://dx.doi.org/10.3343/alm.2020.40.3.274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933059PMC

Rapid Identification of OXA-48-like, KPC, NDM, and VIM Carbapenemase-Producing Enterobacteriaceae From Culture: Evaluation of the RESIST-4 O.K.N.V. Multiplex Lateral Flow Assay.

Ann Lab Med 2020 May;40(3):259-263

Department of Laboratory Medicine and Research Institute of Antimicrobial Resistance, Yonsei University College of Medicine, Seoul, Korea.

There is an urgent need for accurate and rapid diagnostic assays capable of identifying carbapenemase-producing Enterobacteriaceae (CPE). We assessed the performance of the RESIST-4 O.K. Read More

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http://dx.doi.org/10.3343/alm.2020.40.3.259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933055PMC

Isolation of Small Extracellular Vesicles From Human Serum Using a Combination of Ultracentrifugation With Polymer-Based Precipitation.

Ann Lab Med 2020 May;40(3):253-258

Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea.

Methods for reproducibly isolating and enriching small extracellular vesicles (EVs) from blood are essential for clinical utilization of small EVs in cancer patients. We combined ultracentrifugation (UC) with polymer-based precipitation (ExoQuick [EQ] or Total Exosome Isolation [TEI] kit) to isolate small EVs (diameter, 30-150 nm) from the serum of breast cancer patients. We compared the performance of four cycles of UC (UC4x) with that of two cycles of UC followed by enrichment using the EQ (UC2x→EQ) or TEI (UC2x→TEI) kits. Read More

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http://dx.doi.org/10.3343/alm.2020.40.3.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933066PMC

Reporting Quality of Diagnostic Accuracy Studies in Laboratory Medicine: Adherence to Standards for Reporting of Diagnostic Accuracy Studies (STARD) 2015.

Ann Lab Med 2020 May;40(3):245-252

Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Background: Poor reporting quality in diagnostic accuracy studies hampers an adequate judgment of the validity of the study. The Standards for Reporting of Diagnostic Accuracy Studies (STARD) statement was published to improve the reporting quality of diagnostic accuracy studies. This study aimed to evaluate the adherence of diagnostic accuracy studies published in Annals of Laboratory Medicine (ALM) to STARD 2015 and to identify directions for improvement in the reporting quality of these studies. Read More

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http://dx.doi.org/10.3343/alm.2020.40.3.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933069PMC

Prevalence and Clinical Characteristics of Asymptomatic Pyuria in Chronic Kidney Disease.

Ann Lab Med 2020 May;40(3):238-244

Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.

Background: Pyuria seems to be common in chronic kidney disease (CKD), irrespective of urinary tract infection (UTI). It has been hypothesized that sterile pyuria occurs in CKD because of chronic renal parenchymal inflammation. However, there are limited data on whether CKD increases the rate of pyuria or how pyuria in CKD should be interpreted. Read More

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http://dx.doi.org/10.3343/alm.2020.40.3.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933061PMC

Genetic Counseling Status and Perspectives Based on a 2018 Professional Survey in Korea.

Ann Lab Med 2020 May;40(3):232-237

Department of Laboratory Medicine, National Health Insurance Service, Ilsan Hospital, Goyang, Korea.

Background: Genetic counseling (GC) provides many benefits, including the identification of patients appropriate for testing, patient education, and medical management. We evaluated the current status of and challenges faced by GC practitioners in Korean hospitals.

Methods: An electronic survey was designed and conducted in 52 certified laboratory physicians belonging to the Korean Society of Laboratory Medicine, from August to September 2018. Read More

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http://dx.doi.org/10.3343/alm.2020.40.3.232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933060PMC

A Novel Heterozygous Missense Variant (c.667G>T;p.Gly223Cys) in That Interferes With Cadherin-Related 23 and Harmonin Interaction Causes Autosomal Dominant Nonsyndromic Hearing Loss.

Ann Lab Med 2020 May;40(3):224-231

GC Genome, Yongin, Korea.

Background: Pathogenic variants of , encoding a PDZ-domain-containing protein called harmonin, have been known to cause autosomal recessive syndromic or nonsyndromic hearing loss (NSHL). We identified a causative gene in a large Korean family with NSHL showing a typical pattern of autosomal dominant (AD) inheritance.

Methods: Exome sequencing was performed for five affected and three unaffected individuals in this family. Read More

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http://dx.doi.org/10.3343/alm.2020.40.3.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933062PMC

Development and Validation of a Novel Warfarin Dosing Algorithm for Korean Patients With 1173C.

Ann Lab Med 2020 May;40(3):216-223

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Differences in the performance of suggested warfarin dosing algorithms among different ethnicities and genotypes have been reported; this necessitates the development of an algorithm with enhanced performance for specific population groups. Previous warfarin dosing algorithms underestimated warfarin doses in 1173C carriers. We aimed to develop and validate a new warfarin dosing algorithm for Korean patients with 1173C. Read More

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http://dx.doi.org/10.3343/alm.2020.40.3.216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933054PMC