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    32145 results match your criteria Annals of internal medicine[Journal]

    1 OF 643

    Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms: A Population-Based Cohort Study.
    Ann Intern Med 2018 Jan 16. Epub 2018 Jan 16.
    From Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden; Memorial Sloan Kettering Cancer Center, New York, New York; and University of Iceland and Landspítali National University Hospital, Reykjavik, Iceland.
    Background: Patients with myeloproliferative neoplasms (MPNs) are reported to be at increased risk for thrombotic events. However, no population-based study has estimated this excess risk compared with matched control participants.

    Objective: To assess risk for arterial and venous thrombosis in patients with MPNs compared with matched control participants. Read More

    White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk.
    Ann Intern Med 2018 Jan 16. Epub 2018 Jan 16.
    From University of Bergen and Haukeland University Hospital, Bergen, Norway; Oslo University Hospital, Oslo, Norway; Centre National de Recherche en Génomique Humaine, Evry, France; University of Oslo, Oslo, Norway; University of Manchester, St. Mary's Hospital, and University Hospital of South Manchester, Manchester, United Kingdom; and Norwegian University of Science and Technology, Trondheim, Norway.
    Background: The role of normal tissue gene promoter methylation in cancer risk is poorly understood.

    Objective: To assess associations between normal tissue BRCA1 methylation and ovarian cancer risk.

    Design: 2 case-control (initial and validation) studies. Read More

    Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial.
    Ann Intern Med 2018 Jan 9. Epub 2018 Jan 9.
    From Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; Tufts University, Boston, Massachusetts; Wake Forest School of Medicine, Winston-Salem, North Carolina; Pennington Biomedical Research Center, Baton Rouge, Louisiana; Yale School of Medicine, New Haven, Connecticut; Stanford University, School of Medicine, Stanford, California; Tufts University and Boston University School of Medicine, Boston, Massachusetts; University of Florida, Gainesville, Florida; Northwestern University, Feinberg School of Medicine, Chicago, Illinois; University of Pittsburgh, Pittsburgh, Pennsylvania; and University of Maryland School of Medicine, Baltimore, Maryland.
    Background: Limited evidence suggests that physical activity may prevent frailty and associated negative outcomes in older adults. Definitive data from large long-term randomized trials are lacking.

    Objective: To determine whether a long-term, structured, moderate-intensity physical activity program is associated with a lower risk for frailty and whether frailty status alters the effect of physical activity on the reduction in major mobility disability (MMD) risk. Read More

    Diagnosis of Venous Thromboembolism: 20 Years of Progress.
    Ann Intern Med 2018 Jan 9;168(2):131-140. Epub 2018 Jan 9.
    From University of Ottawa, Ottawa Hospital Research Institute, and Ottawa Hospital, Ottawa, Ontario, Canada.
    Many guidelines suggest incorporating clinical assessment, imaging, and D-dimer testing into diagnostic algorithms in patients with suspected deep venous thrombosis (DVT) and pulmonary embolism (PE). This special article reviews the evidence supporting the use of algorithms and their individual components for diagnosis of upper- and lower-extremity DVT and PE in adults, including pregnant women. The authors identified evidence through several electronic database searches to April 2017, evaluated the robustness of selected evidence, assessed whether diagnostic approaches that do not use algorithms are acceptable, and identified knowledge gaps that require further research. Read More

    Device Closure Versus Medical Therapy Alone for Patent Foramen Ovale in Patients With Cryptogenic Stroke: A Systematic Review and Meta-analysis.
    Ann Intern Med 2018 Jan 9. Epub 2018 Jan 9.
    From University of Tennessee and Veterans Affairs Medical Center, Memphis, Tennessee; Virginia Commonwealth University, Richmond, Virginia; Jackson Clinic and University of Tennessee, Jackson, Tennessee; University of Louisville, Louisville, Kentucky; and Duke Clinical Research Institute, Durham, North Carolina.
    Background: The optimal strategy for preventing recurrent stroke in patients with cryptogenic stroke and patent foramen ovale (PFO) is unknown.

    Purpose: To compare transcatheter PFO closure with medical therapy alone for prevention of recurrent stroke in patients with PFO and cryptogenic stroke.

    Data Sources: PubMed and the Cochrane Library (without language restrictions) from inception to October 2017, reference lists, and abstracts from cardiology meetings. Read More

    Percutaneous Closure Versus Medical Treatment in Stroke Patients With Patent Foramen Ovale: A Systematic Review and Meta-analysis.
    Ann Intern Med 2018 Jan 9. Epub 2018 Jan 9.
    From Magna Graecia University, Catanzaro, Italy; Cardiovascular Center Frankfurt, Frankfurt, Germany, and Anglia Ruskin University, Cambridge and Chelmsford, United Kingdom; and Magna Graecia University and Consiglio Nazionale delle Ricerche, Catanzaro, Italy.
    Background: New evidence emerged recently regarding the percutaneous closure of patent foramen ovale (PFO) to prevent recurrent stroke in patients with cryptogenic stroke.

    Purpose: To compare risks for recurrent cerebrovascular events in adults with PFO and cryptogenic stroke who underwent PFO closure versus those who received medical therapy alone.

    Data Sources: PubMed, Scopus, and Google Scholar from 1 December 2004 through 14 September 2017; references of eligible studies; relevant scientific session abstracts; and cardiology Web sites. Read More

    Travel Medicine.
    Ann Intern Med 2018 Jan;168(1):ITC1-ITC16
    From University of Utah School of Medicine, Salt Lake City, Utah; and Harvard Medical School, Boston, Massachusetts.
    International travel can result in new illness or exacerbate existing conditions, and primary care clinicians have the opportunity to provide both pre- and posttravel health care. Providers should be familiar with destination-specific disease risks, be knowledgeable about travel and routine vaccines, be prepared to prescribe chemoprophylaxis and self-treatment regimens, and be aware of travel medicine resources. Read More

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