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    31975 results match your criteria Annals of internal medicine[Journal]

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    Treatment of Type 1 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes.
    Ann Intern Med 2017 Sep 12. Epub 2017 Sep 12.
    From St. Mark's Hospital and St. Mark's Diabetes Center, Salt Lake City, Utah; Johns Hopkins University, Baltimore, Maryland; SinfoníaRx, Tucson, Arizona; Glytec, Marco Island, Florida; Touro University College of Osteopathic Medicine, Vallejo, California; Abington Memorial Hospital, Jenkintown, Pennsylvania; and University of Michigan, Ann Arbor, Michigan.
    Description: The American Diabetes Association (ADA) annually updates Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes.

    Methods: For the 2017 Standards of Care, the ADA Professional Practice Committee did MEDLINE searches from 1 January 2016 to November 2016 to add, clarify, or revise recommendations on the basis of new evidence. The committee rated the recommendations as A, B, or C, depending on the quality of evidence, or E for expert consensus or clinical experience. Read More

    Patterns of Sedentary Behavior and Mortality in U.S. Middle-Aged and Older Adults: A National Cohort Study.
    Ann Intern Med 2017 Sep 12. Epub 2017 Sep 12.
    From Columbia University Medical Center and Weill Cornell Medical Center, New York, New York; University of Alabama at Birmingham, Birmingham, Alabama; University of South Carolina, Columbia, South Carolina; University of Michigan, Ann Arbor, Michigan; Medical University of South Carolina, Charleston, South Carolina; and Arizona State University, Phoenix, Arizona.
    Background: Excessive sedentary time is ubiquitous in Western societies. Previous studies have relied on self-reporting to evaluate the total volume of sedentary time as a prognostic risk factor for mortality and have not examined whether the manner in which sedentary time is accrued (in short or long bouts) carries prognostic relevance.

    Objective: To examine the association between objectively measured sedentary behavior (its total volume and accrual in prolonged, uninterrupted bouts) and all-cause mortality. Read More

    Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials.
    Ann Intern Med 2017 Sep 5. Epub 2017 Sep 5.
    From University of Michigan, Ann Arbor, Michigan; Fred Hutchinson Cancer Research Center, Seattle, Washington; Erasmus Medical Center, Rotterdam, the Netherlands; National Cancer Institute, Bethesda, Maryland; Queen Mary University of London, London, United Kingdom; Sahlgrenska University Hospital, Göteborg, Sweden; Johns Hopkins Medicine, Baltimore, Maryland; University of Tampere, Tampere, Finland; Washington University School of Medicine, St. Louis, Missouri; University of Colorado, Denver, Colorado; Provinciaal Instituut voor Hygiëne, Antwerp, Belgium; Kantonsspital Aarau, Aarau, Switzerland; Institute for Cancer Prevention, Florence, Italy; Universidad Complutense de Madrid, Parla, Madrid, Spain; and Université de Lille, Lille, France.
    Background: The ERSPC (European Randomized Study of Screening for Prostate Cancer) found that screening reduced prostate cancer mortality, but the PLCO (Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial) found no reduction.

    Objective: To evaluate whether effects of screening on prostate cancer mortality relative to no screening differed between the ERSPC and PLCO.

    Design: Cox regression of prostate cancer death in each trial group, adjusted for age and trial. Read More

    Survival After Fulminant Myocarditis Induced by Immune-Checkpoint Inhibitors.
    Ann Intern Med 2017 Sep 5. Epub 2017 Sep 5.
    From Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard Hospital, Université Paris Diderot, Sorbonne Paris Cité, and Institut National de la Santé et de la Recherche Médicale, Paris, France; Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Université Paris Diderot, Sorbonne Paris Cité, and Institut National de la Santé et de la Recherche Médicale, Paris, France; Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard Hospital, Paris, France; Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Paris, France; Assistance Publique-Hôpitaux de Paris, Saint-Antoine Hospital, Paris, France; Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Paris, France; Assistance Publique-Hôpitaux de Paris, Saint-Louis Hospital, Université Paris Diderot, Sorbonne Paris Cité, and Institut National de la Santé et de la Recherche Médicale, Paris, France.

    Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Without Kidney Disease: A Secondary Analysis of a Randomized Trial.
    Ann Intern Med 2017 Sep 5;167(6):375-383. Epub 2017 Sep 5.
    From University of Utah School of Medicine, Salt Lake City, Utah; Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Texas Southwestern Medical Center, Dallas, Texas; Ohio State University, Columbus, Ohio; University of Pennsylvania, Philadelphia, Pennsylvania; University of Minnesota, Minneapolis, Minnesota; National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; University of Illinois at Chicago, Chicago, Illinois; VA Medical Center, Washington, DC; Case Western Reserve University, Cleveland, Ohio; University of California, Los Angeles, Los Angeles, California; VA Medical Center, Albuquerque, New Mexico; VA Medical Center, Memphis, Tennessee; and Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana.
    Background: The public health significance of the reported higher incidence of chronic kidney disease (CKD) with intensive systolic blood pressure (SBP) lowering is unclear.

    Objective: To examine the effects of intensive SBP lowering on kidney and cardiovascular outcomes and contrast its apparent beneficial and adverse effects.

    Design: Subgroup analyses of SPRINT (Systolic Blood Pressure Intervention Trial). Read More

    Diagnostic Accuracy of Novel and Traditional Rapid Tests for Influenza Infection Compared With Reverse Transcriptase Polymerase Chain Reaction: A Systematic Review and Meta-analysis.
    Ann Intern Med 2017 Sep 5;167(6):394-409. Epub 2017 Sep 5.
    From McGill University, McGill University Health Centre, and Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada, and Royal College of Surgeons in Ireland, Dublin, Ireland.
    Background: Rapid and accurate influenza diagnostics can improve patient care.

    Purpose: To summarize and compare accuracy of traditional rapid influenza diagnostic tests (RIDTs), digital immunoassays (DIAs), and rapid nucleic acid amplification tests (NAATs) in children and adults with suspected influenza.

    Data Sources: 6 databases from their inception through May 2017. Read More

    Influenza.
    Ann Intern Med 2017 Sep;167(5):ITC33-ITC48
    From the Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
    Influenza is an acute viral respiratory disease that affects persons of all ages and is associated with millions of medical visits, hundreds of thousands of hospitalizations, and thousands of deaths during annual winter epidemics of variable severity in the United States. Elderly persons have the highest influenza-associated hospitalization and mortality rates. The primary method of prevention is annual vaccination. Read More

    Enhancing the Role of Internists in the Transition From Pediatric to Adult Health Care.
    Ann Intern Med 2017 Sep;167(5):363-364
    From Western Slope Endocrinology, Grand Junction, Colorado; Children's National Medical Center, Washington, DC; American College of Physicians, Washington, DC; University of California, Los Angeles, Los Angeles, California; Tulane University School of Medicine and Southeast Louisiana Veterans Healthcare System, New Orleans, Louisiana; The National Alliance to Advance Adolescent Health, Washington, DC; University of South Carolina, Columbia, South Carolina; The National Alliance to Advance Adolescent Health and the George Washington University School of Medicine and Health Sciences, Washington, DC.

    Do Less Harm: Evaluating HIV Programmatic Alternatives in Response to Cutbacks in Foreign Aid.
    Ann Intern Med 2017 Aug 29. Epub 2017 Aug 29.
    From Massachusetts General Hospital, Brigham and Women's Hospital, Harvard University Center for AIDS Research, Harvard Medical School, Harvard T.H. Chan School of Public Health, and Boston University School of Public Health, Boston, Massachusetts; Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Centre Hospitalier Universitaire de Treichville and Treichville University Hospital, Abidjan, Côte d'Ivoire; University of Bordeaux, Bordeaux, France; and Yale School of Public Health, New Haven, Connecticut.
    Background: Resource-limited nations must consider their response to potential contractions in international support for HIV programs.

    Objective: To evaluate the clinical, epidemiologic, and budgetary consequences of alternative HIV program scale-back strategies in 2 recipient nations, the Republic of South Africa (RSA) and Côte d'Ivoire (CI).

    Design: Model-based comparison between current standard (CD4 count at presentation of 0. Read More

    Accuracy of Cardiovascular Risk Prediction Varies by Neighborhood Socioeconomic Position: A Retrospective Cohort Study.
    Ann Intern Med 2017 Aug 29. Epub 2017 Aug 29.
    From Cleveland Clinic, Case Western Reserve University, and MetroHealth Medical Center, Cleveland, Ohio.
    Background: Inequality in health outcomes in relation to Americans' socioeconomic position is rising.

    Objective: First, to evaluate the spatial relationship between neighborhood disadvantage and major atherosclerotic cardiovascular disease (ASCVD)-related events; second, to evaluate the relative extent to which neighborhood disadvantage and physiologic risk account for neighborhood-level variation in ASCVD event rates.

    Design: Observational cohort analysis of geocoded longitudinal electronic health records. Read More

    Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis of Individual Patient Data.
    Ann Intern Med 2017 Sep 22;167(6):410-417. Epub 2017 Aug 22.
    From Academic Medical Center and Slotervaartziekenhuis, Amsterdam, the Netherlands; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Université de Bretagne Occidentale, Brest, France; Hospital of Padua, Padua, Italy; Clinica Universidad de Navarra, Pamplona, Spain; Virgen del Rocio Hospital, Seville, Spain; Karolinska Institutet, Stockholm, Sweden; Warsaw Medical University, Warsaw, Poland; Centre Hospitalo-Universitaire Estaing, Clermont-Ferrand, France; University of Utah, Salt Lake City, Utah; University Hospital Leuven, Leuven, Belgium; and University G. D'Annunzio, Chieti-Pescara, Italy.
    Background: Screening for cancer in patients with unprovoked venous thromboembolism (VTE) often is considered, but clinicians need precise data on cancer prevalence, risk factors, and the effect of different types of screening strategies.

    Purpose: To estimate the prevalence of occult cancer in patients with unprovoked VTE, including in subgroups of different ages or those that have had different types of screening.

    Data Sources: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials up to 19 January 2016. Read More

    Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women: A Phase 2 Randomized Trial.
    Ann Intern Med 2017 Sep 22;167(6):384-393. Epub 2017 Aug 22.
    From Weill Cornell Medicine, New York, New York; Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington; University of California, Los Angeles, Los Angeles, California; University of Michigan, Ann Arbor, Michigan; Johns Hopkins University School of Medicine, Baltimore, Maryland; University of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; University of North Carolina, Chapel Hill, North Carolina; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; ViiV Healthcare, Durham, North Carolina; Gilead Sciences, Foster City, California; Case Western Reserve University, Cleveland, Ohio; The George Washington University and FHI 360, Washington, DC; Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania; University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Rutgers New Jersey Medical School, Newark, New Jersey; West Virginia University, Morgantown, West Virginia; and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
    Background: Maraviroc (MVC) is a candidate drug for HIV preexposure prophylaxis (PrEP).

    Objective: To assess the safety and tolerability of MVC-containing PrEP over 48 weeks in U.S. Read More

    Continuous Glucose Monitoring Versus Usual Care in Patients With Type 2 Diabetes Receiving Multiple Daily Insulin Injections: A Randomized Trial.
    Ann Intern Med 2017 Sep 22;167(6):365-374. Epub 2017 Aug 22.
    From Jaeb Center for Health Research, Tampa, Florida; Oregon Health & Science University, Portland, Oregon; Diabetes & Glandular Disease Clinic, San Antonio, Texas; Henry Ford Medical Center, Detroit, Michigan; Washington University in St. Louis, St. Louis, Missouri; Behavioral Diabetes Institute and Dexcom, San Diego, California; Research Institute of Dallas, Dallas, Texas; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada; Joslin Diabetes Center, Boston, Massachusetts; and Park Nicollet International Diabetes Center, St. Louis Park, Minnesota.
    Background: Continuous glucose monitoring (CGM), which studies have shown is beneficial for adults with type 1 diabetes, has not been well-evaluated in those with type 2 diabetes receiving insulin.

    Objective: To determine the effectiveness of CGM in adults with type 2 diabetes receiving multiple daily injections of insulin.

    Design: Randomized clinical trial. Read More

    The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms: A Systematic Review.
    Ann Intern Med 2017 Sep 15;167(5):319-331. Epub 2017 Aug 15.
    From VA Portland Health Care System and Oregon Health & Science University, Portland, Oregon.
    Background: Cannabis is increasingly available for the treatment of chronic pain, yet its efficacy remains uncertain.

    Purpose: To review the benefits of plant-based cannabis preparations for treating chronic pain in adults and the harms of cannabis use in chronic pain and general adult populations.

    Data Sources: MEDLINE, Cochrane Database of Systematic Reviews, and several other sources from database inception to March 2017. Read More

    Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older.
    Ann Intern Med 2017 Aug;167(4):291-292
    From Portland Evidence-based Synthesis Program and Portland VA Medical Center, Portland, Oregon; Minneapolis VA Center for Chronic Disease Outcomes Research and University of Minnesota School of Medicine, Minneapolis, Minnesota; American Academy of Family Physicians, Leawood, Kansas; and American College of Physicians, Philadelphia, Pennsylvania.

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