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    1388 results match your criteria Annals of hepatology[Journal]

    1 OF 28

    Fontan-Associated Liver Disease: A Review.
    Ann Hepatol 2018 Mar;17(2):192-204
    Hospital Universitario Ramón y Cajal. Universidad de Alcalá. Servicio de Gastroenterología y Hepatología.
    Fontan-associated liver disease is a hepatic disorder arising from hemodynamic changes and systemic venous congestion following Fontan surgery. The histological changes produced in the liver are similar but not equivalent to those seen in other forms of cardiac liver disease. While the natural history of this form of liver disease is not well established, over time many Fontan patients develop portal hypertension-related complications such as ascites, variceal hemorrhage or encephalopathy. Read More

    Recent Advances in Hepatotoxicity of Non Steroidal Anti-Inflammatory Drugs.
    Ann Hepatol 2018 Mar;17(2):187-191
    Montpellier School of Medicine Liver and Transplantation Unit.
    Non-steroidal-anti-inflammatory drugs (NSAIDs) make a heterogenous pharmaco-therapeutic class of drugs among the most used drugs worldwide with various indications, modes of administration and increasing automedication. NSAIDs can cause acute liver injury with variable severity. The recent identification of genetic markers might facilitate the diagnosis and the prediction of hepatotoxicity risk. Read More

    Nonalcoholic Fatty Liver Disease Progresses into Severe NASH when Physiological Mechanisms of Tissue Homeostasis Collapse.
    Ann Hepatol 2018 Mar;17(2):182-186
    University of Buenos Aires Institute of Medical Research A Lanari, Buenos Aires, Argentina.
    Phenotypic modulation of NAFLD-severity by molecules derived from white (adipokines) and brown (batokines) adipose tissue may be important in inducing or protecting against the progression of the disease. Adipose tissue-derived factors can promote the progression of NAFLD towards severe histological stages (NASH-fibrosis and NASHcirrhosis). This effect can be modulated by the release of adipokines or batokines that directly trigger an inflammatory response in the liver tissue or indirectly modulate related phenotypes, such as insulin resistance. Read More

    Safety and Efficacy of Laparoscopic Radiofrequency Ablation for Hepatic Hemangiomas: A Multicenter Retrospective Study.
    Ann Hepatol 2018 Mar;17(2):268-273
    Foshan Hospital affiliated to Southern Medical University, Foshan 528000, China. Department of Hepatobiliary Surgery.
    Introduction: Radiofrequency ablation (RFA) is an effective and minimally invasive technique for the management of hepatic hemangiomas (HHs). This study aims to assess the safety and efficacy of laparoscopic RFA for HHs.

    Material And Methods: Forty-four patients with 50 hepatic hemangiomas (5-10 cm in diameter) undergoing laparoscopic RFA from January 2012 to May 2015 at three tertiary hospitals in China were retrospectively analyzed. Read More

    Results of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Study.
    Ann Hepatol 2018 Mar;17(2):256-267
    Hospital Universitario Austral. Austral University, Faculty of Medicine. Argentina. On behalf of the Latin American Liver Research, Education and Awareness Network (LALREAN).
    Background And Aims: Heterogeneous data has been reported regarding liver transplantation (LT) for hepatocellular carcinoma (HCC) in Latin America. We aimed to describe treatment during waiting list, survival and recurrence of HCC after LT in a multicenter study from Latin America.

    Material And Methods: Patients with HCC diagnosed prior to transplant (cHCC) and incidentally found in the explanted liver (iHCC) were included. Read More

    Racial, Ethnic, and Age Disparities in Incidence and Survival of Intrahepatic Cholangiocarcinoma in the United States; 1995-2014.
    Ann Hepatol 2018 Mar;17(2):274-285
    Department of Transplantation Mayo Clinic, Jacksonville, Florida, United States.
    Introduction: Despite reports of increased incidence of intrahepatic cholangiocarcinoma (iCCA) in the United States, the impact of age or influences of race and ethnicity are not clear. Disparities in iCCA outcomes across various population subgroups also are not readily recognized due to the rarity of this cancer. We examined ethnic, race, age, and gender variations in iCCA incidence and survival using data from the Surveillance, Epidemiology, and End Results Program (1995-2014). Read More

    Treatment of Type-1 Hepatorenal Syndrome with Pentoxifylline: A Randomized Placebo Controlled Clinical Trial.
    Ann Hepatol 2018 Mar;17(2):300-306
    University of Virginia, Charlottesville, VA, United States. Division of Gastroenterology & Hepatology, Department of Medicine.
    Introduction: Type-1 hepatorenal syndrome (HRS-1) portends a poor prognosis in patients with cirrhosis. Currently available medical therapies are largely ineffective, save for liver transplantation. We aimed to determine if pentoxifylline (PTX) therapy in addition to the standard of care of volume expansion with albumin and vasoconstriction with midodrine and octreotide (AMO) is safe and efficacious compared to AMO in HRS-1 treatment. Read More

    Clinical Significance of Serum Adiponectin and Resistin Levels in Liver Cirrhosis.
    Ann Hepatol 2018 Mar;17(2):286-299
    Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil. Division of Gastroenterology.
    Introduction: Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated with adiponectin and resistin levels and its clinical significance in patients with cirrhosis.

    Materials And Methods: This was a prospective cohort study that included 122 subjects with cirrhosis who attended an outpatient clinic and were initially evaluated in 2012. Read More

    TCR Vβ Usage of Peripheral Blood and Liver Infiltrating Lymphocytes in Patients with Chronic Hepatitis B.
    Ann Hepatol 2018 Mar;17(2):214-222
    Affiliated Hospital of Jining Medical University, China. Clinical Laboratory.
    Introduction: Chronic hepatitis B (CHB) is still a public health problem and its mechanism remains unclear. In this study, we detect the skewness of T cell receptor beta chain variable gene (TCR Vβ) in peripheral blood lymphocytes (PBL) and the liver infiltrating lymphocytes (LIL) of patients with CHB; and hope to provide information for further research on the pathogenic mechanism of CHB.

    Material And Methods: Fifteen patients with CHB, ten healthy volunteers and three patients with liver cysts were recruited as the subjects. Read More

    Viscoelastic Testing in Liver Disease.
    Ann Hepatol 2018 Mar;17(2):205-213
    Center for the Study of Coagulation in Liver Disease University of Virginia, Charlottesville, Virginia, USA.
    Long thought to be hypocoagulable, new evidence suggests cirrhosis patients have "rebalanced" coagulation in the setting of decreased synthesis of both pro- and anti-coagulant factors. Traditional testing like PT/INR reflects only the decreased synthesis of pro-coagulant factors and thus does not correspond to bleeding or clotting risk in this population. In this review, we discuss the use of viscoelastic testing (VET), an assay of global hemostasis in cirrhosis patients. Read More

    More Evidence for the Genetic Susceptibility of Mexican Population to Nonalcoholic Fatty Liver Disease through PNPLA3.
    Ann Hepatol 2018 Mar;17(2):250-255
    Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City.
    Background: The gene for patatin-like phospholipase domain containing 3 (PNPLA3) is associated with nonalcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT levels in individuals with normal weight, overweight and obese. Read More

    Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype.
    Ann Hepatol 2018 Mar;17(2):242-249
    Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. Laboratorio de Investigación clínica y traslacional en enfermedades hepáticas y digestivas y CIBERehd. Instituto de Biomedicina de Sevilla (IBiS).
    Background & aims. G-allele of PNPLA3 (rs738409) favours triglycerides accumulation and steatosis. In this study, we examined the effect of quercetin and natural extracts from mushroom and artichoke on reducing lipid accumulation in hepatic cells. Read More

    Long-Term Follow-up and Quantitative Hepatitis B Surface Antigen Monitoring in North American Chronic HBV Carriers.
    Ann Hepatol 2018 Mar;17(2):232-241
    Calgary Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
    Introduction: Quantitative hepatitis B surface antigen (qHBsAg) combined with HBV DNA may be useful for predicting chronic hepatitis B (CHB) activity and nucleoside analogue (NA) response.

    Material And Methods: In this retrospective cohort study we evaluated qHBsAg levels according to CHB disease phase and among patients on treatment. Random effect logistic regression analysis was used to analyze qHBsAg change with time in the NA-treated cohort. Read More

    Bacterial Translocation Is Linked to Increased Intestinal IFN-γ, IL-4, IL-17, and mucin-2 in Cholestatic Rats.
    Ann Hepatol 2018 Mar;17(2):318-329
    Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara. Guadalajara, Jalisco, México. Instituto de Investigación en Enfermedades Crónico-Degenerativas, Departamento de Biología Molecular y Genómica.
    Background and rationale for the study. Bacterial translocation is an important triggering factor of infection and mortality in cirrhosis. In a rat model using bile duct ligation (BDL), bacterial translocation appears within 24 h after ligation. Read More

    Hepatitis E Virus Genotype 1 Cases Imported to Portugal from India, 2016.
    Ann Hepatol 2018 Mar;17(2):335-338
    Universidade do Porto, 4050-313 Porto, Portugal. Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia.
    Hepatitis E in industrialized countries is mainly associated with genotype 3 hepatitis E virus (HEV) and normally causes a sporadic self-limiting disease in immunocompetent individuals. Unlike genotype 3, genotypes 1 and 2 circulate in developing countries, produce severe disease and occur in the epidemic form. Hepatitis E occurring in travellers returning from endemic areas in developing countries is not a novel epidemiological occurrence, however the vast majority of cases remain to be genetically studied. Read More

    Incomplete Kawasaki Disease in an Infant with Cholangitis Post Kasai Surgery for Biliary Atresia.
    Ann Hepatol 2018 Mar;17(2):332-334
    Pediatric Hepatology, Nanavati Hospital, Mumbai, Maharashtra, India.
    Kawasaki's disease (KD) is a systemic vasculitis often seen with viral and bacterial infections. Cholangitis is a known complication in biliary atresia patients post Kasai Portoenterostomy (KP). However KD, in a biliary atresia patient post KP has not been previously reported. Read More

    Antifibrotic Mechanism of Pinocembrin: Impact on Oxidative Stress, Inflammation and TGF-β /Smad Inhibition in Rats.
    Ann Hepatol 2018 Mar;17(2):307-317
    Pharmacology & Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
    Introduction: The present study aimed to elucidate the potential antifibrotic effects of pinocembrin (PIN), a flavanone found abundantly in honey and propolis, by studying its effect on different oxidative stress, inflammatory and fibrosis markers in an experimental model of CCl4-induced liver fibrosis.

    Material And Methods: PIN (20 mg/kg) was given orally 3 times/week for 6 consecutive weeks alternating with CCl4 (0.5 mL/kg, 1:1 mixture with corn oil, i. Read More

    Early Successes in an Open Access, Provincially Funded Hepatitis C Treatment Program in Prince Edward Island.
    Ann Hepatol 2018 Feb;17(2):223-231
    Dalhousie University, Nova Scotia, Canada, Horizon Health Network, New Brunswick, Canada.
    Introduction: The availability of curative hepatitis C therapies has created an opportunity to improve treatment delivery and access. Local providers, government, industry, and community groups in Prince Edward Island developed an innovative province-wide care model. Our goal was to describe the first year of program implementation. Read More

    Clinical Findings of HCV Chronic Infection in Undocumented Immigrants and Low-Income Refugees in Three Areas of Southern Italy.
    Ann Hepatol 2018 January-February;17(1):47-53
    Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy.
    Introduction And Aim: In recent decades, Italy has become a land of immigration from countries suffering a socio-economic crisis. The aim of this study was to perform an organized screening to identify and offer care to immigrants with HCV infection.

    Material And Methods: The screening, performed from 2012 to 2015, involved 1,727 immigrants in the Campania and Apulia regions in southern Italy. Read More

    High Prevalence of Hepatitis B Subgenotype D4 in Northeast Brazil: an Ancient Relic from African Continent?
    Ann Hepatol 2018 January-February;17(1):54-63
    Laboratory of Tropical Gastroenterology and Hepatology, Medicine and Department of Gastroenterology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
    Introduction: Hepatitis B virus (HBV) infection leads to a chronic liver disease that is distributed worldwide. The characterization of HBV into genotypes/subgenotypes is not only a mere procedure for distinguishing different HBV strains around the world because determining their geographic distribution is crucial to understanding their spread across the world.

    Material And Methods: We characterized different HBV genotypes and subgenotypes in five municipalities located in northeastern Maranhão, in the Brazilian north Atlantic coast. Read More

    Meta-Analysis of Grazoprevir plus Elbasvir for Treatment of Hepatitis C Virus Genotype 1 Infection.
    Ann Hepatol 2018 January-February;17(1):18-32
    Pharmacology Department, Faculty of veterinary medicine, Suez Canal University, Ismailia 41522, Egypt.
    Background And Aim: Grazoprevir is an NS3/4A protease inhibitor (PI), while elbasvir is an NS5A inhibitor. We performed this meta-analysis to directly compare grazoprevir plus elbasvir and ribavirin regimen vs. grazoprevir and elbasvir without ribavirin in the treatment of hepatitis C virus genotype 1 infection and to precisely evaluate the efficacy of the latter regimen in cirrhotic, IL28 CC genotype patients and those coinfected with human immunodeficiency virus. Read More

    Hepatic Hydrothorax.
    Ann Hepatol 2018 January-February;17(1):33-46
    State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
    Hepatic hydrothorax (HH) is a pleural effusion that develops in a patient with cirrhosis and portal hypertension in the absence of cardiopulmonary disease. Although the development of HH remains incompletely understood, the most acceptable explanation is that the pleural effusion is a result of a direct passage of ascitic fluid into the pleural cavity through a defect in the diaphragm due to the raised abdominal pressure and the negative pressure within the pleural space. Patients with HH can be asymptomatic or present with pulmonary symptoms such as shortness of breath, cough, hypoxemia, or respiratory failure associated with large pleural effusions. Read More

    The Changing Face of the Diagnosis of Chronic and Malignant Liver Diseases: Potential New Biomarkers.
    Ann Hepatol 2018 January-February;17(1):14-17
    Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Departments of Gastroenterology & Hepatology.
    The early diagnosis of primary sclerosing cholangitis, hepatocellular carcinoma, and cholangiocarcinoma is often challenging. In a recent study in 134 patients (Arbelaiz, Hepatology 2017; 66:1125-1143), it was reported that specific proteins found in serum extracellular vesicles of patients with primary sclerosing cholangitis, hepatocellular carcinoma,orcholangiocarcinomamay be useful as noninvasive diagnostic and prognostic tools. This current article critically appraises this study. Read More

    Worsening of Serum Lipid Profile after Direct Acting Antiviral Treatment.
    Ann Hepatol 2018 January-February;17(1):64-75
    Hepatology Unit. Department of Medical and Surgical Sciences, University of Bologna and Sant'Orsola-Malpighi Hospital, Bologna, Italy.
    Introduction: Host lipid metabolism influences viral replication and lifecycle of hepatitis C virus. Our aim was to evaluate changes in glucose and lipid metabolism of patients with chronic hepatitis C after therapy with direct acting antivirals (DAA).

    Material And Methods: We considered patients consecutively treated between January and November 2015 recording clinical data at baseline and week 24 of follow-up. Read More

    Recreational Drug and Psychosocial Profile in Chronic Hepatitis C Patients Seeking Antiviral Therapy.
    Ann Hepatol 2018 January-February;17(1):76-84
    Division of Gastroenterology and Hepatology. University of Arkansas for Medical Sciences; Little Rock, Arkansas, USA.
    Background And Aims: Practitioners treating hepatitis C (HCV) provide healthcare to a special population with high rates of substance abuse and psychiatric disorders. We investigated the psychosocial profile in HCV patients and tested what variables affect commencement of antiviral therapy.

    Material And Methods: Recreational drug use (RDU), marijuana (THC), alcohol use, and psychiatric history were initially investigated with a questionnaire prior to history and physical. Read More

    Pyogenic Liver Abscess Secondary to Foreign Body (Fish Bone) Treated by Laparoscopy: A Case Report.
    Ann Hepatol 2018 January-February;17(1):169-173
    DeparTment of Surgery, Postgraduate Course of Surgery, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
    Liver abscess due to perforation of the gastrointestinal tract by a foreign body is a rare and possibly fatal event. Diagnosing this pathology is complicated by the lack of specific symptoms and unfamiliarity of ingestion by the patient and low clinical suspicion of this disease. In the case of liver abscess unresponsive to aspiration and administration of antibiotics, this hypothesis must be made, despite its low incidence. Read More

    Atypical Abdominal Pain in a Patient With Liver Cirrhosis.
    Ann Hepatol 2018 January-February;17(1):162-164
    Gastroenterology Department. National Institute of Medical Science and Nutrition "Salvador Zubirán". Mexico City. Mexico.
    The causes of abdominal pain in patients with liver cirrhosis and ascites are well-known but occasionally, atypical causes arise. We report the case of a patient with a ruptured, confined abdominal aortic aneurysm. Read More

    Hepatic Cyst Compressing The Right Atrial and Ventricular Inflow Tract: An Uncommon Cardiac Complication.
    Ann Hepatol 2018 January-February;17(1):165-168
    Department of Medicine. Metropolitan Hospital Center, New York Medical College, New York, NY, USA.
    Commonly reported complications of hepatic cysts are spontaneous hemorrhage, rupture into the peritoneal cavity, infection and compression of the biliary tree however cardiac complications are not commonly reported. We are presenting a case of a large liver cyst presenting with right atrial and ventricular inflow tract impingement resulting in cardiac symptoms. A 68 year-old Hispanic female presented with one month of fatigue and shortness of breath after household work and walking less than one block, right upper quadrant pain and weight loss. Read More

    Hypericum Humifusum Leaves Attenuates Hepatic Ischemia-Reperfusion Injury in a Rat Model.
    Ann Hepatol 2018 January-February;17(1):144-152
    National Center of Pharmacovigilance, Tunis, Tunisia.
    Introduction: Effective prevention strategies require specific actions during the different phases of ischemia-reperfusion (I-R) injury. The objective of our study is to evaluate the effect of aqueous extract of Hypericum humifusum leaves (HHL) on liver I-R model in Rat.

    Material And Methods: Animals were subjected to 90 min of hepatic ischemia followed by reperfusion (120 min). Read More

    Efficacy of Probiotics and Smectite in Rats with Non-Alcoholic Fatty Liver Disease.
    Ann Hepatol 2018 January-February;17(1):153-161
    Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
    Introduction And Aim: Today probiotics have been suggested as a treatment for the prevention of non-alcoholic fatty liver disease (NAFLD). Smectite is a natural silicate that binds to digestive mucous and has the ability to bind endo- and exotoxins. The present study was designed to determine whether probiotics plus smectite is superior to probiotic alone on the monosodium glutamate (MSG) induced NAFLD model in rats. Read More

    Acute Variceal Bleeding: Does Octreotide Improve Outcomes in Patients with Different Functional Hepatic Reserve?
    Ann Hepatol 2018 January-February;17(1):125-133
    Servicio de Gastroenterología, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, México.
    Background: Current guidelines do not differentiate in the utilization of vasoactive drugs in patients with cirrhosis and acute variceal bleeding (AVB) depending on liver disease severity.

    Material And Methods: In this retrospective study, clinical outcomes in 100 patients receiving octreotide plus endoscopic therapy (ET) and 216 patients with ET alone were compared in terms of failure to control bleeding, in-hospital mortality, and transfusion requirements stratifying the results according to liver disease severity by Child-Pugh (CP) score and MELD.

    Results: In patients with CP-A or those with MELD < 10 octreotide was not associated with a better outcome compared to ET alone in terms of hospital mortality (CP-A: 0. Read More

    Short- and Long-term Outcomes between Young and Older HCC Patients Exceeding The Milan Criteria after Hepatectomy.
    Ann Hepatol 2018 January-February;17(1):134-143
    Department of Liver Surgery & Liver Transplantation Center, West China Hospital, Sichuan University. China.
    Aim: The objective of this study was to evaluate short- and long-term survival after surgical treatment between young and older hepatocellular carcinoma (HCC) patients beyond the Milan criteria.

    Material And Methods: One hundred fifty-seven HCC patients (≤ 55 years old) were categorized into group A, and one hundred fifty-eight HCC patients (> 55 years old) were categorized into group B. Postoperative complications and overall survival were retrospectively analyzed. Read More

    Prognostic ability of BCLC-B Subclassification in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization.
    Ann Hepatol 2018 January-February;17(1):110-118
    Department of Internal Medicine, Fondazione Policlinico Gemelli Catholic University of the Sacred Heart, Rome, Italy.
    Prognostic ability of BCLC-B Subclassification in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Background and aims. A subclassification system for intermediate hepatocellular carcinoma (HCC) was recently proposed to optimize treatment allocation. The aim of this study was to assess the prognostic ability of that substaging proposal. Read More

    Risk and Prognosis of Acute Liver Injury Among Hospitalized Patients with Hemodynamic Instability: A Nationwide Analysis.
    Ann Hepatol 2018 January-February;17(1):119-124
    Division of Gastroenterology & Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Risk and Prognosis of Acute Liver Injury Among Hospitalized Patients with Hemodynamic Instability: A Nationwide Analysis Introduction and aim. Critically ill patients in states of circulatory failure are at risk of acute liver injury, from mild elevations in aminotransferases to substantial rises consistent with hypoxic hepatitis or "shock liver". The present study aims to quantify the national prevalence of acute liver injury in patients with hemodynamic instability, identify risk factors for its development, and determine predictors of mortality. Read More

    Exercise Capacity and Respiratory Profile in Patients after Orthopedic Liver Transplantation: a Follow-up Study.
    Ann Hepatol 2018 January-February;17(1):98-103
    Department of Medicine, Federal University of Ceará. Fortaleza, Ceará, Brazil.
    Introduction: We sought to describe: 1) The influence of orthotopic liver transplantation (OLT) on exercise capacity, pulmonary function and respiratory muscle strength after surgery, 2) The relationship between exercise capacity and symptoms of anxiety and depression.

    Material And Methods: This is a prospective follow up study conducted with patients submitted to OLT. All patients were assessed before and 1 month after surgery through measurements: six minute walk test (6MWT), 6 min step test (6MST) and HADS (Hospital Anxiety and Depression Scale). Read More

    The Portuguese Version of the Immunosuppressant Therapy Adherence Scale (ITAS) among Liver Transplant Recipient Patients: Translation and Psychometric Properties.
    Ann Hepatol 2018 January-February;17(1):104-109
    Programa de Pós-graduação em Medicina e Saúde, Faculdade de Medicina da Universidade Federal da Bahia, Salvador, Bahia, Brazil; Hospital Universitário da Universidade Federal da Bahia, Salvador, Bahia, Brazil.
    Introduction And Aim: Transplant recipients are chronically ill patients who rely on medical treatment throughout life to achieve positive results. Despite that, medication nonadherence after liver transplantation is extremely common. The self-report, one of several methods for measuring adherence, is easy to apply and low cost. Read More

    Association of Adolescent Obesity with Nonalcoholic Fatty Liver Disease and Related Risk Factors in Xi 'an, China.
    Ann Hepatol 2018 January-February;17(1):85-91
    Clinical Laboratory, First Affiliated Hospital of Xi 'an Medical University, Xi 'an , Shaanxi Province, China.
    Introduction And Aim: To investigate the association of adolescent obesity with nonalcoholic fatty liver disease (NAFLD) and related risk factors in Xi 'an, China.

    Material And Methods: A total of 4141 adolescents (2,061 girls and 2,080 boys, mean age: 18.62 ± 0. Read More

    Cultural Validation of the Transplanted Organ Questionnaire (TOQ) for the Brazilian Population.
    Ann Hepatol 2018 January-February;17(1):92-97
    Graduate Program in Medicine: Hepatology, School of Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
    Background And Rationale: The Transplanted Organ Questionnaire (TOQ), developed in France, is a disease-targeted instrument designed to evaluate what the transplanted organ represents to the recipient in patients who have undergone liver transplantation. The present study sought to validate a version of the TOQ for use in the Brazilian population. Translation and cross-cultural adaptation were carried out in accordance with international standard practices. Read More

    The Role of Bile Acids in Glucose Metabolism and Their Relation with Diabetes.
    Ann Hepatol 2017 11;16(Suppl. 1: s3-105.):16-21
    Department of Gastroenterology. Clinic of Digestive Diseases and Obesity. Liver Research Unit. Medica Sur Clinic & Foundation. Mexico City, Mexico.
    Bile acids (BAs), the end products of cholesterol catabolism, are essential for the absorption of lipids and fat-soluble vitamins; but they have also emerged as novel signaling molecules that act as metabolic regulators. It has been well described that the enterohepatic circulation, a nuclear (FXR) and a cytoplasmic (TGR5/M-BAR) receptor aid in controlling hepatic bile acid synthesis. Modulating bile acid synthesis greatly impacts in metabolism, because these receptors also are implicated in glucose, lipid, and energy expenditure. Read More

    Bile Acids and Portal Hypertension
    Ann Hepatol 2017 11;16(Suppl. 1: s3-105.):s83-s86
    Departamento de Gastroenterología, Escuela de Medicina. Pontificia Universidad Católica de Chile. Santiago, Chile.
    The recent discovery of bile acid (BA) receptors and a better delineation of the multiple roles of BAs in relevant biological processes have revamped BA research. The vasoactive actions of BAs were recognized more than three decades ago but the underlying mechanisms of the BA-induced vasorelaxation are now being clarified. Recent evidence shows that the BA receptors FXR and TGR5 are expressed in endothelial cells and may have important effects on both systemic and portal circulation. Read More

    Bile Acids and Cancer: Direct and Environmental-Dependent Effects.
    Ann Hepatol 2017 11;16(Suppl. 1: s3-105.):s87-s105
    Clinica Medica "A. Murri", Department of Biomedical Sciences & Human Oncology, University of Bari Medical School, Bari, Italy.
    Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but have also a key role as singalling molecules and in the modulation of epithelial cell proliferation, gene expression and metabolism. These homeostatic pathways, when disrupted, are able to promote local inflammation, systemic metabolic disorders and, ultimately, cancer. The effect of hydrophobic BAs, in particular, can be linked with cancer in several digestive (mainly oesophagus, stomach, liver, pancreas, biliary tract, colon) and extra-digestive organs (i. Read More

    Bile Acids in Nonalcoholic Fatty Liver Disease: New Concepts and therapeutic advances.
    Ann Hepatol 2017 11;16(Suppl. 1: s3-105.):s58-s67
    Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico.
    Nonalcoholic liver disease (NAFLD) is a major emerging health burden that is a common cause of illness and death worldwide. NAFLD can progress into nonalcoholic steatohepatitis (NASH) which is a severe form of liver disease characterized by inflammation and fibrosis. Further progression leads to cirrhosis, which predisposes patients to hepatocellular carcinoma or liver failure. Read More

    Cross-Talk Between Bile Acids and Gastro-Intestinal and Thermogenic Hormones: Clues from Bariatric Surgery
    Ann Hepatol 2017 11;16(Suppl. 1: s3-105.):s68-s82
    Department of Biomedical Sciences and Human Oncology, Clinica Medica "A. Murri", University of Bari Medical School, Bari, Italy.
    Obesity is rapidly increasing and has reached epidemic features worldwide. It´s linked to insulin resistance, systemic low-grade inflammation and common pathogenic pathways with a number of comorbidities (including cancer), leading to high mortality rates. Besides change of lifestyles (diet and physical exercise) and pharmacological therapy, bariatric surgery is able to rapidly improve several metabolic and morphologic features associated with excessive fat storage, and currently represents an in vivo model to study the pathogenic mechanisms underlying obesity and obesity-related complications. Read More

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