1,509 results match your criteria Annals of hepatology[Journal]


ALBI and PALBI: Novel Scores for Outcome Prediction of Cirrhotic Outpatients Awaiting Liver Transplantation.

Ann Hepatol 2018 Oct;17(6):906-907

Liver and Pancreas Transplant and Hepatobiliary Surgery Unit, Hospital de Clínicas de Porto Alegre, Medical School of UFRGS, Porto Alegre, Brazil.

Cirrhosis has four different stages that encompass mild stable compensated cirrhosis, stable cirrhosis with prior decompensation, acutely decompensated cirrhosis and acute-on-chronic liver failure. A worse ALBI score has been associated to an increased mortality in a recent study involving patients with stable cirrhosis and prior decompensation. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7190DOI Listing
October 2018
3 Reads

Immunometabolic Effect of Cholesterol in Hepatitis C Infection: Implications in Clinical Management and Antiviral Therapy.

Ann Hepatol 2018 Oct;17(6):908-919

Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde" and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.

Hepatitis C virus (HCV) is a lipid-enveloped virion particle that causes infection to the liver, and as part of its life cycle, it disrupts the host lipid metabolic machinery, particularly the cholesterol synthesis pathway. The innate immune response generated by liver resident immune cells is responsible for successful viral eradication. Unfortunately, most patients fail to eliminate HCV and progress to chronic infection. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7191DOI Listing
October 2018
6 Reads

The Evolving Role of Liver Biopsy in Non-alcoholic Fatty Liver Disease.

Ann Hepatol 2018 Oct;17(6):899-902

Departamento de Gastroenterología, Escuela de Medicina. Pontificia Universidad Católica de Chile, Santiago, Chile.

Evaluation patients with nonalcoholic steatohepatitis (NASH) imply the need of appropriate assessment of disease severity (i.e. the presence of nonalcoholic steatohepatitis (NASH)) as well as of the disease stage (i. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7188DOI Listing
October 2018
2 Reads

Computed Tomography and Magnetic Resonance Imaging Features of Primary and Secondary Hepatic Glycogenosis.

Ann Hepatol 2018 Oct;17(6):903-905

Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, PR China.

Glycogen storage disease type I and glycogenic hepatopathy are the most common type of primary and secondary hepatic glycogenosis, with presenting common radiological features of hepatomegaly, hepatic signal, or density change. Beyond that, glycogen storage disease type I shows hepatocellular adenomas or fatty liver, while glycogenic hepatopathy does not. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7189DOI Listing
October 2018
8 Reads

Financial and Other Competing Interests: Be Aware.

Ann Hepatol 2018 Oct;17(6):897-898

Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde" and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.

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http://dx.doi.org/10.5604/01.3001.0012.7187DOI Listing
October 2018
1 Read

Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model.

Ann Hepatol 2018 Oct;17(6):980-991

Department of Biology, Faculty of Science, Ataturk University, Erzurum, TURKEY.

Introduction And Aim: Indo is widely one of the non-steroidal anti-inflammatory drugs and one of the common toxic effects of this drug is hepatic failure. Thymol is a monoterpene phenol with many different pharmacological activities. However, up to now its hepatoprotective effects on Indo-induced gastric ulcer model in rats have not been explored yet. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7198DOI Listing
October 2018
1 Read

The -250G/A and -514C/T Polymorphisms in Hepatic Lipase Gene Promoter Confers an Increased Risk of Hepatocellular Carcinoma in a Chinese Population.

Ann Hepatol 2018 Oct;17(6):992-1000

Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, P.R. China.

Introduction And Aim: Hepatocellular carcinoma (HCC) is a lethal malignancy, but the molecular mechanisms of hepatocarcinogenesis remain undefined. The present study aims to investigate the relationship between polymorphisms of the hepatic lipase (HL) gene promoters and risk of HCC.

Material And Methods: Totally, 279 HCC patients and 200 healthy individuals were enrolled. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7199DOI Listing
October 2018
1 Read
2.193 Impact Factor

Response to Loco-Regional Therapy Predicts Outcomes After Liver Transplantation for Combined Hepatocellular-Cholangiocarcinoma.

Ann Hepatol 2018 Oct;17(6):969-979

Department of Transplantation, Mayo Clinic, Jacksonville, FL, USA.

Introduction And Aim: Combined hepatocellular-cholangiocarcinoma (HCC-CCA) is a rare liver malignancy distinct from either hepatocellular carcinoma (HCC) or cholangiocarcinoma. Liver transplantation (LT) is not recommended for HCC-CCA because of suboptimal outcomes. Non-invasive diagnosis of HCC-CCA is extremely challenging; thus, some HCC-CCAs are presumed as HCC on imaging and listed for LT with the correct diagnosis ultimately made on explant pathology. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7197DOI Listing
October 2018
1 Read

Drug-Drug Interactions in Hepatitis Patients: Do these Interactions Matter in Clinical Perspectives?

Ann Hepatol 2018 Oct;17(6):1001-1011

Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan.

Introduction And Aim: Hepatitis patients usually present with comorbidities and polypharmacy which increases risk of potential drug-drug interactions (pDDIs). We explored frequency, levels, predictors, and clinical relevance of pDDIs in hospitalized hepatitis patients.

Material And Methods: Retrospective cohort study was used. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7200DOI Listing
October 2018
1 Read

MicroRNA Profile in Peripheral Blood Mononuclear Cells from Hepatitis B Virus Infected Patients.

Ann Hepatol 2018 Oct;17(6):1012-1020

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Introduction And Aim: The pathogenesis of hepatitis B virus (HBV)-related liver diseases remains not fully understood. Here, we aim to explore the potential roles of dysregulated miRNAs in chronic hepatitis B (CHB) and HBV-related acute-on-chronic liver failure (ACLF).

Material And Methods: MiRNA microarray was conducted in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors or patients with CHB or ACLF. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7201DOI Listing
October 2018
2 Reads
2.193 Impact Factor

Clinicopathological Distinction of Low-AFP-Secreting vs. High-AFP-Secreting Hepatocellular Carcinomas.

Ann Hepatol 2018 Oct;17(6):0-100

Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology-Transplant Hepatology, Baltimore, MD, United States.

Introduction And Aims: We aimed to investigate the clinical and pathological differences between low-AFP-secreting (AFP < 20 ng/mL) and high-AFP-secreting (AFP ≥ 20 ng/mL) hepatocellular carcinomas in patients who undergo liver transplant (LT).

Material And Methods: We evaluated 145 patients who underwent deceased donor LT for HCC from January 1, 2005 until August 1, 2015 at the Johns Hopkins Hospital.

Results: Median pre-LT AFP in the entire cohort was 13 ng/mL (IQR 6-59). Read More

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http://dx.doi.org/10.5604/01.3001.0012.7206DOI Listing
October 2018
2 Reads

Association of Parity in Patients with Chronic Liver Disease.

Ann Hepatol 2018 Oct;17(6):1035-1041

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States.

Introduction And Aim: The impact of type of liver disease on parity rates hasn't been described. Our aim was to assess the parity rates among women with CLD.

Material And Methods: The National Health and Nutrition Examination Survey-III (1988-1994) data were used to identify adult female participants with a diagnosis of CLD. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7204DOI Listing
October 2018
6 Reads

Thromboelastography Parameters in Patients with Acute on Chronic Liver Failure.

Ann Hepatol 2018 Oct;17(6):1042-1051

Introduction And Aim: Patients with acute on chronic liver failure (ACLF) have abnormal conventional coagulation tests- platelet count and international normalized ratio (INR). Thromboelastography (TEG) is a rapid, point-of-care assay, more comprehensive than platelet count and INR as it assesses for platelet adequacy (number and function), coagulation factors and clot retraction. The aim of the study was to evaluate the TEG parameters in patients with ACLF, chronic liver disease having acute decompensation (AD) and healthy subjects (HC). Read More

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http://dx.doi.org/10.5604/01.3001.0012.7205DOI Listing
October 2018
2 Reads

Association of Interleukin-6 and Interleukin-1 Family Gene Polymorphisms in Autoimmune Hepatitis.

Ann Hepatol 2018 Oct;17(6):1021-1025

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction And Aim: Autoimmune hepatitis (AIH) is an immune-mediated destruction of liver cells, in recognition of interface hepatitis, seropositivity for autoantibodies, and interface hepatitis in histology sections. Hepatocyte destruction in AIH is the direct result of CD4+ T-cell destruction. Yet, Th17 mediated immune attach and a diversity of cytokine networks, including pro-inflammatory cytokines such as Interleukin 1 (IL-1) and Interleukin 6 (IL-6), set the stage for the destructive liver damage. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7202DOI Listing
October 2018
1 Read
2.193 Impact Factor

Gene Therapy for Treatment of Chronic Hyperammonemia in a Rat Model of Hepatic Encephalopathy.

Ann Hepatol 2018 Oct;17(6):1026-1034

Departamento de Gastroenterología. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico.

Introduction And Aim: Hepatic encephalopathy (HE), caused by hyperammonemia resulting from liver disease, is a spectrum of neuropsychiatric and motor disorders that can lead to death. Existing therapies are deficient and alternative treatments are needed. We have shown that gene therapy with a baculovirus vector containing the glutamine synthetase (Bac-GS) gene is efficient for reducing ammonia levels in an acute hyperammonemia rat model. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7203DOI Listing
October 2018
2 Reads

Efficacy and Safety of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir ± Ribavirin for HCV in Brazilian Adults with Advanced Fibrosis.

Ann Hepatol 2018 Oct;17(6):959-968

Department of Medicine, Gastroenterology Division, Ribeirao Preto School of Medicine, University of São Paulo, Brazil.

Introduction And Aim: Approximately 650,000 people in Brazil have chronic hepatitis C virus (HCV) infection. We evaluated the safety and efficacy of ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r) plus dasabuvir (DSV) with/without ribavirin (RBV) in an openlabel multicenter phase 3b trial in treatment-naive or interferon (IFN) treatment-experienced Brazilian patients with advanced hepatic fibrosis (METAVIR F3/4) and HCV genotype (GT) 1 infection.

Material And Methods: All patients received coformulated OBV/PTV/r daily + DSV twice daily (3-DAA). Read More

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http://dx.doi.org/10.5604/01.3001.0012.7196DOI Listing
October 2018
2 Reads

The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes.

Ann Hepatol 2018 Oct;17(6):940-947

Department of Gastroenterology and Hepatology, the Fourth People's Hospital of Chongqing (Chongqing Emergency Medical Center), Chongqing, China.

Introduction And Aim: Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previous studies. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7194DOI Listing
October 2018
1 Read

Infection and Predictors of Outcome of Cirrhotic Patients after Emergency Care Hospital Admission.

Ann Hepatol 2018 Oct;17(6):948-958

2nd Medical Department, Technische Universität München, Klinikum rechts der Isar, Germany.

Introduction And Aims: We aimed to explore the impact of infection diagnosed upon admission and of other clinical baseline parameters on mortality of cirrhotic patients with emergency admissions.

Material And Methods: We performed a prospective observational monocentric study in a tertiary care center. The association of clinical parameters and established scoring systems with short-term mortality up to 90 days was assessed by univariate and multivariable Cox regression analysis. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7195DOI Listing
October 2018
5 Reads

An Argument for Vitamin D, A, and Zinc Monitoring in Cirrhosis.

Ann Hepatol 2018 Oct;17(6):920-932

Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, USA.

Malnutrition is prevalent in cirrhosis. Vitamin and mineral deficiencies, including vitamin D, vitamin A, and zinc, are common and have been shown to correlate with survival. Our aim was to review the mechanisms of vitamin D, vitamin A, and zinc deficiencies in cirrhosis and the clinical assessment of affected patients, their outcomes based on the current literature, and management. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7192DOI Listing
October 2018
4 Reads

Effect of Proton Pump Inhibitors on Mortality in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis.

Ann Hepatol 2018 Oct;17(6):933-939

School of Medicine, Tzu Chi University, Hualien, Taiwan.

Introduction And Aim: Spontaneous bacterial peritonitis (SBP) is a life-threatening infection in patients with cirrhosis. However, it is unknown whether patients with SBP and cirrhosis who do not have active gastrointestinal bleeding have a poorer prognosis if treated with proton pump inhibitors (PPI).

Material And Methods: We used the Taiwan National Health Insurance Database to identify 858 patients with SBP and cirrhosis who were administered PPIs and hospitalized between January 1, 2010, and December 31, 2013. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7193DOI Listing
October 2018
2 Reads

Improvement in Waldenström's Macroglobulinemia after Successful Treatment of HCV with Direct-acting Antivirals.

Ann Hepatol 2018 Oct;17(6):1072-1077

Gastroenterology Unit, Ospedale Policlinico San Martino, IRCCS per l'Oncologia, University of Genoa, Genoa, Italy.

Chronic hepatitis C (HCV) virus infection may be associated with several non-hepatic manifestations, mainly driven by chronic immune stimulation, such as mixed cryoglobulinemia and Non-Hodgkin's Lymphoma. This association has been proved by several meta-analyses and some interventional studies demonstrating that antiviral treatment may be effective in inducing HCV-associated lymphoma regression. The recent advent of direct acting antivirals (DAAs) in the therapeutic armamentarium of HCV infection made possible treatment of patients with advanced liver disease. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7208DOI Listing
October 2018
3 Reads

Thrombosis of the Portal Venous System in Cirrhotic Patients.

Ann Hepatol 2018 Oct;17(6):1078-1080

Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.5604/01.3001.0012.7209DOI Listing
October 2018
1 Read

Nodular Regenerative Hyperplasia Induced by Trastuzumab Emtansine: Role of Emtansine?

Ann Hepatol 2018 Oct;17(6):1067-1071

Department of pathology, CHU de Grenoble-Alpes, Grenoble, France.

Trastuzumab is a monoclonal antibody targeted against the Human Epidermal Growth Factor Receptor 2 (HER2) overexpressed in some breast cancer. This targeted therapy significantly improves the prognosis of these cancers. Recently an anti-HER2 antibodydrug conjugate was shaped in order to facilitate the targeted delivery of potent cytotoxic drug to cancer cells and to reduce resistance. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7207DOI Listing
October 2018
1 Read

miR-182-5p Attenuates High-Fat -Diet-Induced Nonalcoholic Steatohepatitis in Mice.

Ann Hepatol 2018 Dec;18(1):116-125

Department of Neonatal Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.

Introduction And Aim: Patients with NASH have increased risk for sepsis or cardiovascular disease after Liver transplantation. An important role of Toll-like receptor (TLR) 4 in the pathogenesis of nonalcoholic steatohepatitis (NASH) was demonstrated. Here, we study the role of miR-182-5p in TLR4 expression and high-fat-diet (HFD)-induced NASH in vitro and in vivo. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7902DOI Listing
December 2018
6 Reads

Efficacy and Tolerability of Ombitasvir/Paritaprevir/Ritonavir in HCV Genotype 1-infected Elderly Japanese Patients.

Ann Hepatol 2018 Dec;18(1):109-115

Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, Japan.

Introduction And Aim: We assessed the characteristics of virological response to a combination treatment of ombitasvir, paritaprevir, and ritonavir in hepatitis C virus genotype 1-infected elderly Japanese patients.

Material And Methods: This multicenter prospective study was conducted at six locations in Japan. Seventy patients with chronic hepatitis C virus genotype 1b infection were orally administered ombitasvir/paritaprevir/ritonavir once daily for 12 weeks. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7868DOI Listing
December 2018
2 Reads

Effect of Portal Vein Ligation Plus Venous Congestion on Liver Regeneration in Rats.

Ann Hepatol 2018 Dec;18(1):89-100

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Introduction And Aim: We developed a rat model of portal vein ligation (PVL) with venous congestion (PVL+C) to investigate beneficial effect PVL plus congestion for regeneration of intact liver segments.

Materials And Methods: In the PVL group, portal vein branches were ligated except the caudate lobe (CL). In the PVL + C group, the left lateral hepatic vein was ligated in addition to PVL. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7866DOI Listing
December 2018
1 Read

Treatment with Melatonin Improves Cognitive Behavior and Motor Skills in a Rat Model of Liver Fibrosis.

Ann Hepatol 2018 Dec;18(1):101-108

Department of Biomedical Sciences. Faculty of Medicine. Universidad Católica del Norte. Coquimbo. Chile.

Introduction And Aim: Patients with liver cirrhosis (LC) and minimal hepatic encephalopaty have a higher accident rate. LC impairs the normal sleep-awake cycle and produces disturbances in behavior, cognition and motor skills. Abnormal melatonin (MT) levels have also been identified in LC. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7867DOI Listing
December 2018
2 Reads

Lysosomal Acid Lipase Deficiency Leading to Liver Cirrhosis: a Case Report of a Rare Variant Mutation.

Ann Hepatol 2018 Dec;18(1):78-88

Department of Gastroenterology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.

Lysosomal acid lipase deficiency is a poorly diagnosed genetic disorder, leading to accumulation of cholesterol esters and triglycerides in the liver, with progression to chronic liver disease, dyslipidemia, and cardiovascular complications. Lack of awareness on diagnosis of this condition may hamper specific treatment, which consists on enzymatic replacement. It may prevent the progression of liver disease and its complications. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7865DOI Listing
December 2018
4 Reads

Choosing Wisely Canada-Top Five List in Hepatology: Official Position Statement of the Canadian Association for the Study of the Liver (CASL) and ChoosingWisely Canada (CWC).

Ann Hepatol 2018 Dec;18(1):165-171

Francis Family Liver Clinic, University of Toronto, Canada.

Introduction And Aim: The prevalence and incidence of chronic liver disease is increasing resulting in substantial direct and indirect medical costs. Overuse of investigations, treatments and procedures contribute to rising health care costs and can expose patients to unnecessary harm and delay in receiving care. The Choosing Wisely Canada (CWC) campaign has encouraged profesional societies to develop statements that are directly actionable by their members in an effort to promote higher-value health care that will lead to downstream effect on how other practitioners make decisions. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7908DOI Listing
December 2018
4 Reads

Metabolomics Discloses a New Non-invasive Method for the Diagnosis and Prognosis of Patients with Alcoholic Hepatitis.

Ann Hepatol 2018 Dec;18(1):144-154

Liver Unit, Hospital Clínic, Barcelona, Spain.

Introduction And Aims: Alcoholic hepatitis is the most severe manifestation of alcoholic liver disease. Unfortunately, there are still some unresolved issues in the diagnosis and management of this disease, such as the need of histological diagnosis, an accurate prognostic stratification, and the development of novel targeted therapies. The present study aimed at addressing these issues by means of metabolomics, a novel high-throughput approach useful in other liver diseases. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7906DOI Listing
December 2018
2 Reads

Serum NGAL Is Superior to Cystatin C in Predicting the Prognosis of Acute-on-Chronic Liver Failure.

Ann Hepatol 2018 Dec;18(1):155-164

Institute of Hepatology, the Third People's Hospital of Changzhou, Changzhou, Jiangsu, China.

Introduction And Aim: Acute-on-chronic liver failure (ACLF) is a syndrome with high short-term mortality, and predicting the prognosis is challenging. This study aimed to compare the performance of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) in predicting the 90-day mortality in patients with hepatitis B virus (HBV)-associated ACLF (HBV-ACLF).

Materials And Methods: This prospective, observational study enrolled 54 patients with HBV-ACLF. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7907DOI Listing
December 2018
2 Reads

ALBI and PALBI Grades are Associated with the Outcome of Patients with Stable Decompensated Cirrhosis.

Ann Hepatol 2018 Dec;18(1):126-136

Fourth Department of Internal Medicine, Medical School of Aristotle University, Thessaloniki, Greece.

Introduction And Aim: Studies carried out mainly in patients with hepatocellular carcinoma (HCC), have shown the prognostic significance of albumin-bilirubin (ALBI) grade. Recently, another predictive score incorporating platelet count into ALBI, PALBI grade, was introduced in patients with HCC.

Aim: We evaluated the ability of ALBI and PALBI grades in predicting the outcome (mortality / liver transplantation) of patients with stable decompensated cirrhosis with various etiology of liver diseases. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7904DOI Listing
December 2018
1 Read

Interferon-Free Regimen: Equally Effective in Treatment Naive and Experienced HCV Patients.

Ann Hepatol 2018 Dec;18(1):137-143

Department of Gastroenterology, University of Medicine and Pharmacy Tirgu Mures, Romania.

Introduction And Aim: Interferon-free regimen has been reported to be highly efficient in treatment of HCV infection, including patients with compensated cirrhosis. We compared the efficacy of Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir and Ribavirin (OBT/PTV/r, with DSV and RBV) therapy in patients with chronic HCV genotype 1b infection and compensated cirrhosis with and without prior treatment experience with pegylated interferon and ribavirin (IFN/RBV).

Material And Methods: A prospective twocenter study was conducted in Mures County Hospital and Brasov County Hospital, Romania in period November 2015-July 2016. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7905DOI Listing
December 2018
17 Reads

Case Series Regarding Parastomal Variceal Bleeding: Presentation and Management.

Ann Hepatol 2018 Dec;18(1):250-257

Department of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham AL, USA.

Parastomal variceal bleeding (PVB) is a serious complication occurring in up to 27% of patients with an ostomy and concurrent cirrosis and portal hypertension. The management of PVB is difficult and there are no clear guidelines on this matter. Transjugular intrahepatic portosystemic shunt (TIPS), sclerotherapy, and /or coil embolization are all therapies that have been shown to successfully manage PVB. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7934DOI Listing
December 2018
2 Reads

Biliary Paracoccidioidomycosis: An Unusual Infection Simulating Malignant Neoplasm.

Ann Hepatol 2018 Dec;18(1):258-262

Hepatobiliary Surgery, Bonsucesso Federal Hospital, Health Ministry, Rio de Janeiro, Brazil.

Paracoccidioidomycosis is a systemic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis and is restricted to Latin America. It normally affects lungs, skin and lymph nodes. Abdominal organs are usually not involved. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7935DOI Listing
December 2018
2 Reads

A duplicated Gallbladder in a Patient Presenting with Acute Cholangitis. A Case Study and a Literature Review.

Ann Hepatol 2018 Dec;18(1):240-245

2nd Dept. of Surgery, "Aretaieio" Hospital, National and Kapodistrian University of Athens, School of Medicine, Greece.

Gallbladder duplication can present a clinical challenge primarily due to difficulties with diagnosis and identification. Recognition of this anomaly and its various types is important since it can complicate a gallbladder disease or a simple hepatobiliary surgical procedure. The case report of a 63-year-old woman who presented with cholangitis and underwent a successful laparoscopic management of symptomatic gallbladder duplication is described, emphasizing several important considerations. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7932DOI Listing
December 2018
16 Reads
2.193 Impact Factor

Type II Abernethy Malformation in a Patient with Primary Budd-Chiari Syndrome.

Ann Hepatol 2018 Dec;18(1):246-249

Department of Intervention, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Budd-Chiari syndrome (BCS) is a heterogeneous group of disorders characterized by hepatic venous outflow obstruction. Abernethy malformation is a congenital vascular malformation defined by diversion of portal blood away from the liver. Both conditions are rare vascular diseases. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7933DOI Listing
December 2018
2 Reads

Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done.

Ann Hepatol 2018 Dec;18(1):236-239

Gastroenterology and Hepatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Nowadays, the retreatment of patients with Hepatitis C virus (HCV) genotype 3 (GT3) especially cirrhotic, who have already been treated with regimens containing a NS5A inhibitor represents a challenge. Use a novel retreatment option for patients with a difficult approach. We present three case reports of retreatment with a new combination of Direct-acting antivirals (DAAs), Sofosbuvir, Elbasvir/ Grazoprevir in patients with GT3 with a previous failure with Sofosbuvir/Ledipasvir. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7931DOI Listing
December 2018
3 Reads

Implications of Manganese in Chronic acquired hepatocerebral degeneration.

Ann Hepatol 2018 Dec;18(1):274-278

Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Canada.

Neurological symptoms can be one of the over-riding symptoms in patients with liver cirrhosis. Patients can present with subtle changes in mood or neurological function due to hepatic encephalopathy (HE), to more severe presentations including stupor and coma. While HE, in its severe form, can be clinically easy to diagnose, more subtle forms may be more difficult to recognize. Read More

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https://annalsofhepatology.publisherspanel.com/gicid/01.3001
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http://dx.doi.org/10.5604/01.3001.0012.7938DOI Listing
December 2018
3 Reads

Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report.

Ann Hepatol 2018 Dec;18(1):263-268

Institute of Liver Studies, King's College Hospital, London, UK.

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7936DOI Listing
December 2018
3 Reads

Laparoscopic Partial ALPPS: Much Better Than ALPPS!

Ann Hepatol 2018 Dec;18(1):269-273

Department of Digestive Surgery and Transplantation, Huriez Hospital, University of Lille, France.

Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) has emerged as an alternative for patients with bilobar colorectal liver metastasis deemed unresectable due to inadequate future remnant liver (FRL). Nevertheless, high morbidity and mortality rates have been reported. In this setting, including hepatobiliary scintigraphy in the clinical and surgical management of patients offered ALPPS has been advocated to both assess eligibility for ALPPS stage1 and suitable time for ALPPS stage2. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7937DOI Listing
December 2018
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HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study.

Ann Hepatol 2018 Dec;18(1):68-77

Tropical Medicine & Hepatology, Cairo Faculty of Medicine.

Introduction And Aim: Hepatitis C virus (HCV) infection is a global medical problem. HLA -DRB1 alleles have an important role in immune response against HCV. The aim of this study is to clarify the contribution of HLA -DRB1 alleles in HCV susceptibility in a multicentre family-based study. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7864DOI Listing
December 2018
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2.193 Impact Factor

The Role of the CLIF-C OF and the 2016 MELD in Prognosis of Cirrhosis with and without Acute-on-Chronic Liver Failure.

Ann Hepatol 2018 Dec;18(1):48-57

Gastroenterology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Introduction And Aim: Acute-on-chronic liver failure (ACLF) is defined by the development of acute deterioration of liver function associated with failure of other organs and high short-term mortality in patients with chronic liver disease (CLD). There is no consensus on the diagnostic criteria, and its independence from ordinary decompensation of CLD has frequently been questioned. This study aimed to identify and characterize this condition and to test the CLIF-C OF score comparing it to the 2016-MELD (with sodium) and the Child-Pugh. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7862DOI Listing
December 2018
2 Reads

Performance of Serum Glypican 3 in Diagnosis of Hepatocellular Carcinoma: A meta-analysis.

Ann Hepatol 2018 Dec;18(1):58-67

Department of Human Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.

Introduction And Aim: Serum glypican-3 (GPC3) has been explored as a non-invasive biomarker of hepatocellular carcinoma (HCC). However, controversy remains on its diagnostic accuracy. Therefore, we aimed to conduct a systematic review and metaanalysis to evaluate the differential diagnostic accuracy of serum GPC3 between HCC and liver cirrhosis (LC) cases. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7863DOI Listing
December 2018
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Celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9.

Ann Hepatol 2018 Dec;18(1):40-47

Cangzhou Central Hospital, No. 16, Xinhuazhong Road, Cangzhou City, Hebei Province, China.

Introduction And Aim: Matrix metalloproteinase (MMP)-2 and MMP-9 are reported to participate in several pregnancy-related diseases, including intrahepatic cholestasis of pregnancy (ICP), which is a severe liver disorder in pregnant women. Meanwhile, ample evidences have demonstrated that celastrol inhibits the activity and expression of MMPs. The present study aims to examine the effect of celastrol to alleviate symptoms of ICP in rat model. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7860DOI Listing
December 2018
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Predictors of 1-month and 3-months Hospital Readmissions in Decompensated Cirrhosis: A Prospective Study in a Large Asian Cohort.

Ann Hepatol 2018 Dec;18(1):30-39

Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and Hospital, Mumbai, Maharashtra, India.

Introduction And Aim: Considered as a healthcare quality indicator, hospital readmissions in decompensated cirrhosis predispose the patients and the society to physical, social and economic distresses. Few studies involving North American cohorts have identified different predictors. The aim of this study was to determine and validate the predictors of 1-month and 3-months readmission in an Asian cohort. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7859DOI Listing
December 2018
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2.193 Impact Factor

Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion.

Ann Hepatol 2018 Dec;18(1):220-224

Transplant and Advanced Liver Disease Center, Banner University Medical Center Phoenix, Phoenix, AZ, USA.

Immune reconstitution syndrome is a recognized complication with initiation of highly active antiretroviral therapy for acquired immune deficiency syndrome patients co-infected with hepatitis B. Hepatitis B flares are seen in 20%-25% of patients after initiation of highly active antiretroviral therapy, an estimated 1%-5% of whom develop clinical hepatitis. We present a case of highly active antiretroviral therapy initiation for HIV that led to a flare of HBV activity despite antiviral therapy directed towards both. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7918DOI Listing
December 2018
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Clinical Presentation and Anatopathologic Finding of a Hepatic Vascular Hamartoma: a Case Report.

Ann Hepatol 2018 Dec;18(1):225-229

Division of General Surgery, Sanchinarro Hospital, San Pablo University, Madrid, Spain.

HVH (hepatic vascular hamartoma) is a tumor like malformation arising from the vascular tissue of the liver. HVH has been previously reported in animals and presents distintive features from the most frequent benign tumor like malformation of the liver, the hepatic mesenchymal hamartoma (HMH). Herein we report a case of HVH localized in hepatic segment 4b, involving the gastro hepatic ligament, successfully treated with total excision. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7919DOI Listing
December 2018
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Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity.

Ann Hepatol 2018 Dec;18(1):215-219

Liver Unit, Internal Medicine Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

IgG4-related disease is a recently-described fibro-inflammatory condition with characteristic histopathological findings in the organs involved. The most commonly affected organs are pancreas, lymph nodes, and retroperitoneum. Liver disease usually involves bile structures and therefore IgG4-related disease is considered a cause of secondary sclerosing cholangitis. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7916DOI Listing
December 2018
1 Read