1,426 results match your criteria Annals of hepatology[Journal]

Occult Hepatitis B and Other Unexplored Risk Factors for Hepatocellular Carcinoma in Latin America.

Sonia Roman

Ann Hepatol 2018 Jun;17(4):541-543

Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, and Health Sciences Center, University of Guadalajara, Mexico.

Occult hepatitis B infection (OBI) is the presence of hepatitis B virus (HBV) DNA in the liver and/or serum (< 200 IU/mL) in HBsAgnegative patients with or without serologic markers of previous viral exposure. The clinical significance of OBI is of concern in posttransfusional hepatitis B infection, hepatitis B reactivation, chronic liver disease and hepatocellular carcinoma (HCC). The diagnosis of OBI relays on the use of highly sensitive and specific laboratory techniques. Read More

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SVR 24 Achievement Two Weeks After a Tripled Dose of Daclatasvir in an HCV Genotype 3 Patient.

Ann Hepatol 2018 July - August ,;17(4):661-664

Department of Medical Sciences, Section of Infectious Diseases and Dermatology, University of Ferrara, Ferrara, Italy.

Directly-acting antivirals (DAA) have changed the chronic hepatitis C virus (HCV) infection therapeutic scenario allowing virus eradication in more than 95% of patients, independently from the genotype, with 12 to 24-week treatment regimens. We describe a 51-year-old Pakistani man with a chronic HCV-genotype 3 (GT3a) infection with moderate liver fibrosis, who achieved sustained virological response (SVR) 24 after a tripled dose of Daclatasvir (DCV) taken erroneously associated to Sofosbuvir (SOF). The patient had a concomitant intestinal TB infection whose treatment had been delayed in order to firstly eradicate HCV to reduce the liver toxicity of anti-mycobacterial drugs. Read More

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June 2018
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Rapamycin Combi with TAE on the Growth, Metastasis, and Prognosis of Hepatocellular Carcinoma in Rat Models.

Ann Hepatol 2018 July - August ,;17(4):645-654

Department of Central Sterile Supply, the First People's Hospital of Jingzhou, Jingzhou, Hubei, P.R. China First Hospital affiliated to Yangtze University, Jingzhou, Hubei Province, China.

Introduction And Aim: To investigate the effect of mTOR inhibitor Rapamycin combined with transcatheter arterial embolization (TAE) on the growth, metastasis, and prognosis of hepatocellular carcinoma (HCC) in rat model.

Material And Method: McARH7777 cells were used to construct rat models of HCC, which were randomly divided into Model, Rapamycin, TAE, and Rapamycin + TAE groups. Quantitative reverse transcription-PCR (qRT-PCR) and Western Blot were used to detect the expression of Epithelial-Mesenchymal Transition (EMT)-related molecules, and immunohistochemical staining to determine the expression of EMTrelated proteins, angiogenic factors as well as microvessel density (MVD)-CD34. Read More

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Undue Elevation of Procalcitonin in Pediatric Paracetamol Intoxication is Not Explained by Liver Cell Injury Alone.

Ann Hepatol 2018 July - August ,;17(4):631-637

Department of Pediatrics I, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. Essen, Germany.

Introduction And Aim: Procalcitonin is widely used as a biomarker to distinguish bacterial infections from other etiologies of systemic inflammation. Little is known about its value in acute liver injury resulting from intoxication with paracetamol.

Material And Methods: We performed a single-center retrospective analysis of the procalcitonin level, liver synthesis, liver cell damage and renal function of patients admitted with paracetamol-induced liver injury to a tertiary care children's hospital. Read More

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Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature.

Ann Hepatol 2018 July - August ,;17(4):655-660

Department of Internal Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan.

A 76-year-old woman was referred to our hospital due to massive gingival bleeding following teeth extraction. Laboratory findings suggested disseminated intravascular coagulopathy (DIC). Enhanced computed tomography and magnetic resonance imaging disclosed multiple hypervascular liver masses of 2-6 cm in diameter, the largest of which displaying an irregular enhancement pattern. Read More

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Pattern of Vascular Involvement in Egyptian Patients with Budd-Chiari Syndrome: Relation to Etiology and Impact on Clinical Presentation.

Ann Hepatol 2018 July - August ,;17(4):638-644

Department of Radiodiagnosis and Interventional Radiology, Ain Shams University, Cairo, Abbasia, Egypt.

Introduction And Aim: Budd-Chiari syndrome (BCS) is caused by hepatic venous outflow obstruction. This work aims to analyze the pattern of vascular involvement in Egyptian patients with BCS, demonstrates its relation to etiology and shows its impact on clinical presentation.

Material And Methods: The current retrospective study was conducted at The Tropical Medicine Department, Ain Shams University on one hundred Egyptian patients with confirmed diagnosis of primary BCS who were presented to the Budd-Chiari Study Group (BCSG) from April 2014 to May 2016 by collecting clinical, laboratory and radiological data from their medical records. Read More

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Association between Low Testosterone Levels and Sarcopenia in Cirrhosis: A Cross-sectional Study.

Ann Hepatol 2018 July - August ,;17(4):615-623

Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada.

Introduction And Aim: Sarcopenia is an independent predictor of mortality in cirrhosis. Hypogonadism is common in cirrhosis and has been associated with sarcopenia in non-cirrhotic chronic liver disease populations. The aim of this study is to investigate if sarcopenia is associated with low testosterone levels in patients with cirrhosis. Read More

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Urinary Neutrophil Gelatinase-Associated Lipocalin in Cirrhotic Patients with Acute Kidney Injury.

Ann Hepatol 2018 July - August ,;17(4):624-630

Hepato-Gastroenterology Department, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.

Introduction And Aim: It is well known that development of acute kidney injury (AKI) increases mortality in hospitalized cirrhotic patients; therefore many novel markers have been studied for early detection, differential diagnosis and prognosis in cirrhotic patients with AKI. The aim of the current work is to evaluate urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a diagnostic biomarker for different causes of acute kidney injury in liver cirrhosis and to assess it as a prognostic marker.

Material And Methods: Out of 83 cirrhotic patients with AKI admitted between October 2015 and June 2016; 70 patients were included in this prospective study. Read More

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Racial, Ethnic, and Age Disparities in Incidence and Survival of Intrahepatic Cholangiocarcinoma in the United States; 1995-2014.

Ann Hepatol 2018 July - August ,;17(4):604-614

Department of Transplantation Mayo Clinic, Jacksonville, Florida, United States.

Introduction And Aim: Despite reports of increased incidence of intrahepatic cholangiocarcinoma (iCCA) in the United States, the impact of age or influences of race and ethnicity are not clear. Disparities in iCCA outcomes across various population subgroups also are not readily recognized due to the rarity of this cancer. We examined ethnic, race, age, and gender variations in iCCA incidence and survival using data from the Surveillance, Epidemiology, and End Results Program (1995-2014). Read More

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Frequency and Characteristics of Occult Hepatitis B Infection Among Hepatocellular Carcinoma Patients in Japan.

Ann Hepatol 2018 July - August ,;17(4):596-603

The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan.

Introduction And Aim: Occult hepatitis B virus (HBV) infection (OBI) represents a state without detectable hepatitis B surface antigen, but positive for HBV DNA. The correlation between OBI and hepatocellular carcinoma (HCC) carcinogenesis is controversial. We studied the frequency and characteristics of OBI among HCC patients and metastatic liver cancer patients. Read More

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Correlation of APRI Index with Metavir Index in Children with Neonatal Cholestasis Without Biliary Atresia.

Ann Hepatol 2018 July - August ,;17(4):592-595

Department of Pediatric Gastroenterology and Hepatology, B J Wadia Hospital for Children, Mumbai, India.

Introduction And Aim: Neonatal cholestasis constitutes for 19 to 33% of all chronic liver disease in India. Cholestasis leads to fibrosis of liver and ultimately cirrhosis. There are various methods of diagnosis of fibrosis of liver like fibroscan, APRI index, FIB-4, fibro index, forns index, heap score, magnetic elastography. Read More

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Impact of Diabetes Mellitus and Insulin on Nonalcoholic Fatty Liver Disease in the Morbidly Obese.

Ann Hepatol 2018 July - August ,;17(4):585-591

Department of Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

Introduction And Aim: The prevalence of obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease are increasing. Type 2 diabetes mellitus may aggravate non-alcoholic fatty liver disease, increasing the risk of developing cirrhosis and hepatocellular carcinoma. This study aims to determine the effect of type 2 diabetes mellitus and insulin therapy on non-alcoholic fatty liver disease in the patients with morbid obesity. Read More

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June 2018
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Association Between Serum Hemoglobin Levels and Non Alcoholic Fatty Liver Disease in a Mexican Population.

Ann Hepatol 2018 July - August ,;17(4):577-584

Translational Research Unit, Medica Sur Clinic & Foundation. Mexico City, Mexico.

Introduction And Aim: Nonalcoholic fatty liver disease (NAFLD) is closely associated with overweight and obesity, becoming one of the most prevalent hepatic diseases nowadays. Circulating hemoglobin (Hb) concentration is significantly higher in people with NAFLD, compared to healthy patients. While liver biopsy remains the gold standard for NAFLD diagnosis, it is not the best technique due to adverse events that may occur. Read More

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Extracellular Matrix Proteins Substantiate IL-28B T allele Effect on Histological Outcome of Chronic Hepatitis C.

Ann Hepatol 2018 July - August ,;17(4):569-576

Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Egypt.

Introduction And Aim: The correlation between interleukin-28B (IL-28B) polymorphisms and chronic hepatitis C (CHC) progression is debatable. Here, we aimed to evaluate the relation between IL-28B C/T genotypes and the development of cirrhotic liver. Extracellular matrix (ECM) proteins, FibroScan and model for end-stage liver disease (MELD) were used to substantiate the severity of liver disease. Read More

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New Insights About Albumin and Liver Disease.

Ann Hepatol 2018 July - August ,;17(4):547-560

Department of Gastroenterology and Hepatology, Hospital Santa Maria, Lisbon, Portugal.

Decompensated liver cirrhosis has a dismal prognosis, with an overall survival of 2-4 years, which is worse than for many oncological diseases. Albumin is an important tool in the management of patients with cirrhosis, since it decreases for less than half the risk for post-paracentesis cardiocirculatory dysfunction and mortality associated with spontaneous bacterial infection, as well as, it triplicates the response to terlipressin in patients with hepatorenal syndrome. Recently, research on albumin has been a hot topic, with important new insights such as the characterization of the pleiotropic effects of albumin (which surpass its oncotic properties) and the concept of effective albumin concentration. Read More

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Relationship of Severity of Hepatitis A with Polymorphisms in Hepatitis A Virus Cellular Receptor 1 (HAVCR1) Gene.

Ann Hepatol 2018 July - August ,;17(4):561-568

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India Biomedical Informatics Centre, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India.

Introduction And Aim: HAVCR1 protein is the cellular receptor for hepatitis A virus (HAV). Genetic polymorphism in this gene may alter the outcome of HAV infection. In a previous study, a 6-amino acid insertion (157insMTTTVP) in HAVCR1 gene was associated with more severe disease. Read More

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Hepatitis E Virus: Still an Enigma in Mexico.

Ann Hepatol 2018 July - August ,;17(4):544-546

Immunovirology Unit, Molecular Biology Service, Civil Hospital of Guadalajara Fray Antonio Alcalde, Center University of Health Sciences, University of Guadalajara, Mexico.

Based on high seroprevalence, null surveillance, and lack of diagnostics, Mexico is a high-risk region for hepatitis E Virus (HEV) infection. However, few local news on infection are available. Clinicians and general population are in need of increasing awareness, and preventive measures should be emphasized. Read More

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The Observed Effect of Gastric Bypass Surgery on Direct-acting Antiviral Treatment: a Case Report.

Ann Hepatol 2018 May-June;17(3):525-529. Epub 2018 Apr 9.

Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands.

Chronic hepatitis C virus (HCV) infection can be cured with treatment using direct-acting antivirals (DAAs). Although these drugs have been widely studied, information about certain special populations is missing. In this case report we describe a treatment-experienced patient with chronic HCV infection genotype 1b, treated with 150 mg/day simeprevir, 400 mg/day sofosbuvir, and 1,000 mg/ day ribavirin for 24 weeks, after a Roux-and-Y gastric bypass. Read More

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HCBP6 Is Involved in the Development of Hepatic Steatosis Induced by High-Fat Diet and CCL4 in Rats.

Ann Hepatol 2018 May-June;17(3):511-518. Epub 2018 Apr 9.

Department of Endocrine and Metabolic Diseases, 1st Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong province, China.

Introduction And Aim: Hepatitis C virus core-binding protein 6 (HCBP6) was previously found to be an hepatitis C virus corebinding protein, its biological function remains unclear. Our research aims to investigate the role of HCBP6 in the development of hepatic steatosis induced by high-fat diet and carbon tetrachloride (CCL4) in rats.

Material And Methods: Eighteen Wistar rats were randomly allocated into 3 groups: control group, model group 1, and model group 2. Read More

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Mucinous Cystic Neoplasm of the Liver or Intraductal Papillary Mucinous Neoplasm of the Bile Duct? A Case Report and a Review of Literature.

Ann Hepatol 2018 May-June;17(3):519-524. Epub 2018 Apr 9.

Department of Surgery, University Hospital Brno Bohunice, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Mucinous cystic neoplasm of the liver (MCN-L) and intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) are diagnoses that were classified by the World Health Organization in 2010 as mucin-producing bile duct tumors of the hepatobiliary system. The preoperative differential diagnosis between these two entities is difficult; the presence of a communication with the bile duct is usually considered as a typical sign of IPMN-B. However, the presence of an ovarian-like stroma (OLS) has been established to define the diagnosis of MCN-L. Read More

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Potential Molecular Targets of Statins in the Prevention of Hepatocarcinogenesis.

Ann Hepatol 2018 May-June;17(3):490-500. Epub 2018 Apr 9.

Laboratory of Biological Effects of Environmental Pollutants, Department of Human Biochemistry, School of Medicine. Universidad de Buenos Aires. Ciudad Autónoma de Buenos Aires, Argentina.

Hepatocellular carcinoma (HCC) represents 90% of liver tumors. Statins, may reduce the incidence of various tumors, including HCC. Antitumoral activities may be mediated by changes in transforming growth factor-beta (TGF-β1) and thyroid hormones (TH) regulation. Read More

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Therapeutic Effect of HGF on NASH Mice Through HGF/c-Met and JAK2-STAT3 Signalling Pathway.

Ann Hepatol 2018 May-June;17(3):501-510. Epub 2018 Apr 9.

Department of Gastroenterology, First hospital of Shanxi Medical University, Taiyuan, Shanxi, P.R. China.

Introduction And Aim: Hepatocyte growth factor (HGF) has been shown to ameliorate liver inflammation and fibrosis; however, the mechanism underlying its effects in non-alcoholic steatohepatitis (NASH) is unclear. This study aimed to analyse the relationship between the JAK2-STAT3 signalling pathway and the ameliorating effect of HGF on NASH.

Material And Methods: Mice were fed a high-fat diet (HFD) for 16 weeks, and then plasma and hepatic tissues were collected. Read More

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Thrombosis of the Portal Venous System in Cirrhotic vs. Non-Cirrhotic Patients.

Ann Hepatol 2018 May-June;17(3):476-481. Epub 2018 Apr 9.

Liver Research Unit. Medica Sur Clinic & Foundation, Mexico City, Mexico.

Introduction And Aim: Thrombosis is a vascular disorder of the liver often associated with significant morbidity and mortality. Cirrhosis is a predisposing factor for portal venous system thrombosis. The aim of this study is to determine differences between cirrhotics and non-cirrhotics that develop thrombosis in portal venous system and to evaluate if cirrhosis severity is related to the development of portal venous system thrombosis. Read More

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April 2018
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Modulatory Effect of Dietary Inclusion of Aegle marmelos Fruits against Cisplatin - Induced Hepatotoxicity In Wistar Rats.

Ann Hepatol 2018 May-June;17(3):482-489. Epub 2018 Apr 9.

Department of Pharmaceutical Chemistry, Siddhi Vinayaka Institute of Technology & Sciences, Bilaspur, Chhattisgarh, India.

Introduction And Aim: Aegle marmelos is an important traditional herbal medicine used in India. The dietary inclusion of the plant has never exposed earlier for its hepatoprotective activity. This study aimed to investigate the modulator efficacy of dietary inclusion of Aegle marmelos against Cisplatin - induced hepatotoxicity in Wistar albino rats. Read More

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Non-Alcoholic Fatty Liver Disease in Children and Adolescents: Lifestyle Change - a Systematic Review and Meta-Analysis.

Ann Hepatol 2018 May-June;17(3):345-354. Epub 2018 Apr 9.

Federal University of Health Sciences of Porto Alegre (UFCSPA), Brazil.

Introduction And Aim: This manuscript seeks to analyze the impact of lifestyle changes on body mass index (BMI), aminotransferases and steatosis in children and adolescents with nonalcoholic fatty liver disease (NAFLD).

Materials And Methods: A review of PubMed, BIREME, Scopus, EMBASE, Medline and Web of Science databases 2015 was performed seeking studies addressing the impact of lifestyle interventions on children and/or adolescents with NAFLD. Inclusion were manuscripts written in Portuguese, English and Spanish, as well as age less than 18 years. Read More

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LncRNA-Regulated Autophagy and its Potential Role in Drug-Induced Liver Injury.

Ann Hepatol 2018 May-June;17(3):355-363. Epub 2018 Apr 9.

Liver Diseases Center, Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.

Introduction And Aim: Autophagy and its regulated pathways participate in many important cellular physiology and pathological processes involving protein aggregates, damaged mitochondria, excessive peroxisomes, ribosomes, and invading pathogens. This study aimed to review recently published studies and further describe the long noncoding RNA (lncRNA)-regulated autophagy during drug-induced liver injury (DILI).

Material And Methods: DILI, autophagy, autophagy-related genes (ATGs), and lncRNA were used as key words to search published studies from PubMed, Google Scholar, and Web of Science. Read More

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April 2018
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The Presence and Severity of Nonalcoholic Steatohepatitis Is Associated with Specific Changes in Circulating Bile Acids.

Ann Hepatol 2018 May-June;17(3):340-341. Epub 2018 Apr 9.

Department of Gastroenterology, Hepatology and Infectious diseases, University Hospital Magdeburg, Germany.

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease nowadays with currently no approved therapies for the disease. The liver plays a pivotal role in lipid and glucose metabolism. The interactions of molecular mechanisms on the gut for example influences the development still needs to be understood. Read More

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Viewpoint: "Alcohol Consumption in Late Adolescence is Associated with an Increased Risk of Severe Liver Disease Later in Life".

Ann Hepatol 2018 May-June;17(3):343-344. Epub 2018 Apr 9.

Gastroenterology and Hepatology Service, Clinica Santa Chiara, Locarno, Switzerland.

Drinking alcohol during adolescence predispose to severe liver disease in the adult phase. This is the main message of this prospective study. Each daily gram of alcohol men consumed in their youth was linked with a two percent increase in the risk of severe liver disease. Read More

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A New Stage in Annals of Hepatology.

Ann Hepatol 2018 May-June;17(3):339-340. Epub 2018 Apr 9.

Medica Sur Clinic & Foundation. Mexico City, Mexico.

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Vitamin D Deficiency is not Associated with Fatty Liver in a Mexican Population.

Ann Hepatol 2018 May-June;17(3):419-425. Epub 2018 Apr 9.

Department of Endocrinology. National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.

Introduction And Aim: Association of vitamin D deficiency (VDD) with fatty liver (FL) disease is controversial. The purpose of this study was to analyze the association of VDD with FL.

Material And Methods: Cross-sectional study. Read More

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Comparison of Dynamic Changes Among Various Prognostic Scores in Viral Hepatitis-Related Acute Liver Failure.

Ann Hepatol 2018 May-June;17(3):403-412. Epub 2018 Apr 9.

Department of Gastroenterology and Human nutrition, All India Institute of Medical Sciences, New Delhi, India.

Introduction And Aim: Multiple prognostic scores are available for acute liver failure (ALF). Our objective was to compare the dynamicity of model for end stage liver disease (MELD), MELD-sodium, acute liver failure early dynamic model (ALFED), chronic liver failure (CLIF)-consortium ACLF score and King's College Hospital Criteria (KCH) for predicting outcome in ALF.

Materials And Methods: All consecutive patients with ALF at a tertiary care centre in India were included. Read More

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Direct Acting Antivirals Improve HCV Treatment Initiation and Adherence Among Underserved African Americans.

Ann Hepatol 2018 May-June;17(3):413-418. Epub 2018 Apr 9.

Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Liver Center, University of California San Francisco, San Francisco, CA, USA.

Introduction And Aim: Adherence to hepatitis C (HCV) care was suboptimal in the interferon era among underserved African Americans (AA), but adherence data in the era of direct acting antivirals (DAA) is lacking in this population. We aimed to evaluate the impact of DAA on HCV care in underserved AA.

Material And Methods: Clinical records of AAs undergoing HCV evaluation attending a safety net health system liver clinic were reviewed from 2006 to 2011 (pre-DAA), and January 1, 2014 to December 31, 2016 (post-DAA). Read More

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Association Between Hepatitis C Virus and Chronic Kidney Disease: A Systematic Review and Meta-Analysis.

Ann Hepatol 2018 May-June;17(3):364-391. Epub 2018 Apr 9.

Division of Nephrology, Maggiore Hospital and IRCCS Foundation, Milano, Italy; University School of Medicine, Milano, Italy.

Introduction And Aim: The role of hepatitis C virus infection as a risk factor for the development and progression of chronic kidney disease in the general population remains unclear.

Material And Methods: A systematic review of the published medical literature was performed to assess whether positive anti-HCV serologic status is associated with higher frequency of chronic kidney disease in the adult general population. We used a random-effects model to generate a summary estimate of the relative risk of chronic kidney disease (defined by lowered glomerular filtration rate or detectable proteinuria) with HCV across the published studies. Read More

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A Dynamic Model for Predicting Outcome in Patients with HBV Related Acute-On-Chronic Liver Failure.

Ann Hepatol 2018 May-June;17(3):392-402. Epub 2018 Apr 9.

Beijing Youan Hospital, Capital Medical University, China. Collaborative Innovation Center of Infectious diseases.

Introduction And Aim: Accurately predicting the prognosis of individual patient is crucial in the management of ACLF. We aimed to establish a specific prognostic model for HBV-related ACLF patients treated with nucleoside analog (NA).

Material And Methods: We prospectively collected 205 ACLF cases diagnosed according to the APASL criteria. Read More

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Prognostic Significance of The New Criteria for Acute Kidney Injury in Cirrhosis.

Ann Hepatol 2018 May-June;17(3):461-469. Epub 2018 Apr 9.

Núcleo de Estudos em Gastroenterologia e Hepatologia, Internal Medicine Department, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Background: New criteria for acute kidney injury (AKI) in cirrhosis have been proposed, but its prognostic significance is unclear. This study aims to evaluate the prognostic significance of the AKI criteria in cirrhotic patients hospitalized for acute decompensation.

Material And Methods: This is a prospective cohort study. Read More

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Alcohol Consumption Influences Clinical Outcome in Patients Admitted to a Referral Center for Liver Disease.

Ann Hepatol 2018 May-June;17(3):470-475. Epub 2018 Apr 9.

Postgraduate Program in Medicine: Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.

Introduction And Aim: Excessive alcohol consumption is a public health concern worldwide and has been associated with high mortality rates. This study aimed to determine the prevalence of alcohol consumption and its influence on the prognosis of hospitalized cirrhotic patients in a tertiary care hospital.

Material And Methods: We reviewed the medical records of all patients with hepatic cirrosis admitted between January 2009 and December 2014, in a referral center for liver disease in southern Brazil. Read More

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Sofosbuvir-Based Therapy in the Pre-Liver Transplant Setting: The Canadian National Experience.

Ann Hepatol 2018 May-June;17(3):437-443. Epub 2018 Apr 9.

Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, Canada.

Introduction And Aim: Sofosbuvir (SOF)-based regimen has been shown to have high efficacy even in patients with decompensated cirrhosis. Treated patients may experience various degrees of hepatic recovery ranging from stabilization of liver function, to removal from liver transplant wait lists. The frequency of these occurrences in larger transplant eligible patient populations is unknown. Read More

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April 2018
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Antiproliferative Effects of Epigenetic Modifier Drugs Through E-cadherin Up-regulation in Liver Cancer Cell Lines.

Ann Hepatol 2018 May-June;17(3):444-460. Epub 2018 Apr 9.

Grupo de Investigación e Innovación Biomédica - GI2B, Instituto Tecnológico Metropolitano, ITM. Medellín, Colombia.

Introduction And Aim: Epigenetic alterations play an essential role in cancer onset and progression, thus studies of drugs targeting the epigenetic machinery are a principal concern for cancer treatment. Here, we evaluated the potential of the combination of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5aza-dC) and the pan-deacetylase inhibitor Trichostatin A (TSA), at low cytotoxic concentrations, to modulate the canonical Wnt/β-catenin pathway in liver cancer cells.

Material And Methods: Pyrosequencing was used for DNA methylation analyses of LINE-1 sequences and the Wnt/β-catenin pathway antagonist DKK3, SFRP1, WIF1 and CDH1. Read More

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April 2018
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An Overview of Liver Transplant Pathology: Data from a Tertiary Referral Centre in Western India.

Ann Hepatol 2018 May-June;17(3):426-436. Epub 2018 Apr 9.

Department of Hepatobiliary surgery and Liver Transplant, Kokilaben Dhirubhai Ambani Hospital and Medical Research Centre, Mumbai, Maharashtra, India.

Introduction And Aim: 1. Study of liver explants - Etiologic types of end-stage chronic liver disease (ESCLD) and acute liver failure (ALF) in adults and children. 2. Read More

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Fontan-Associated Liver Disease: A Review.

Ann Hepatol 2018 Mar;17(2):192-204

Hospital Universitario Ramón y Cajal. Universidad de Alcalá. Servicio de Gastroenterología y Hepatología.

Fontan-associated liver disease is a hepatic disorder arising from hemodynamic changes and systemic venous congestion following Fontan surgery. The histological changes produced in the liver are similar but not equivalent to those seen in other forms of cardiac liver disease. While the natural history of this form of liver disease is not well established, over time many Fontan patients develop portal hypertension-related complications such as ascites, variceal hemorrhage or encephalopathy. Read More

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March 2018
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Recent Advances in Hepatotoxicity of Non Steroidal Anti-Inflammatory Drugs.

Ann Hepatol 2018 Mar;17(2):187-191

Montpellier School of Medicine Liver and Transplantation Unit.

Non-steroidal-anti-inflammatory drugs (NSAIDs) make a heterogenous pharmaco-therapeutic class of drugs among the most used drugs worldwide with various indications, modes of administration and increasing automedication. NSAIDs can cause acute liver injury with variable severity. The recent identification of genetic markers might facilitate the diagnosis and the prediction of hepatotoxicity risk. Read More

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March 2018
1 Read

Nonalcoholic Fatty Liver Disease Progresses into Severe NASH when Physiological Mechanisms of Tissue Homeostasis Collapse.

Ann Hepatol 2018 Mar;17(2):182-186

University of Buenos Aires Institute of Medical Research A Lanari, Buenos Aires, Argentina.

Phenotypic modulation of NAFLD-severity by molecules derived from white (adipokines) and brown (batokines) adipose tissue may be important in inducing or protecting against the progression of the disease. Adipose tissue-derived factors can promote the progression of NAFLD towards severe histological stages (NASH-fibrosis and NASHcirrhosis). This effect can be modulated by the release of adipokines or batokines that directly trigger an inflammatory response in the liver tissue or indirectly modulate related phenotypes, such as insulin resistance. Read More

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March 2018
1 Read

Natural Extracts as Modifiers of Intracellular Lipid Handling.

Ann Hepatol 2018 Mar;17(2):180-181

University of Gothenburg, Sweden Department of Molecular and Clinical Medicine.

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March 2018
1 Read

Safety and Efficacy of Laparoscopic Radiofrequency Ablation for Hepatic Hemangiomas: A Multicenter Retrospective Study.

Ann Hepatol 2018 Mar;17(2):268-273

Foshan Hospital affiliated to Southern Medical University, Foshan 528000, China. Department of Hepatobiliary Surgery.

Introduction: Radiofrequency ablation (RFA) is an effective and minimally invasive technique for the management of hepatic hemangiomas (HHs). This study aims to assess the safety and efficacy of laparoscopic RFA for HHs.

Material And Methods: Forty-four patients with 50 hepatic hemangiomas (5-10 cm in diameter) undergoing laparoscopic RFA from January 2012 to May 2015 at three tertiary hospitals in China were retrospectively analyzed. Read More

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March 2018
2 Reads

Results of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Study.

Ann Hepatol 2018 Mar;17(2):256-267

Hospital Universitario Austral. Austral University, Faculty of Medicine. Argentina. On behalf of the Latin American Liver Research, Education and Awareness Network (LALREAN).

Background And Aims: Heterogeneous data has been reported regarding liver transplantation (LT) for hepatocellular carcinoma (HCC) in Latin America. We aimed to describe treatment during waiting list, survival and recurrence of HCC after LT in a multicenter study from Latin America.

Material And Methods: Patients with HCC diagnosed prior to transplant (cHCC) and incidentally found in the explanted liver (iHCC) were included. Read More

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March 2018
6 Reads

Racial, Ethnic, and Age Disparities in Incidence and Survival of Intrahepatic Cholangiocarcinoma in the United States; 1995-2014.

Ann Hepatol 2018 Mar;17(2):274-285

Department of Transplantation Mayo Clinic, Jacksonville, Florida, United States.

Introduction: Despite reports of increased incidence of intrahepatic cholangiocarcinoma (iCCA) in the United States, the impact of age or influences of race and ethnicity are not clear. Disparities in iCCA outcomes across various population subgroups also are not readily recognized due to the rarity of this cancer. We examined ethnic, race, age, and gender variations in iCCA incidence and survival using data from the Surveillance, Epidemiology, and End Results Program (1995-2014). Read More

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March 2018
1 Read

Treatment of Type-1 Hepatorenal Syndrome with Pentoxifylline: A Randomized Placebo Controlled Clinical Trial.

Ann Hepatol 2018 Mar;17(2):300-306

University of Virginia, Charlottesville, VA, United States. Division of Gastroenterology & Hepatology, Department of Medicine.

Introduction: Type-1 hepatorenal syndrome (HRS-1) portends a poor prognosis in patients with cirrhosis. Currently available medical therapies are largely ineffective, save for liver transplantation. We aimed to determine if pentoxifylline (PTX) therapy in addition to the standard of care of volume expansion with albumin and vasoconstriction with midodrine and octreotide (AMO) is safe and efficacious compared to AMO in HRS-1 treatment. Read More

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March 2018
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Clinical Significance of Serum Adiponectin and Resistin Levels in Liver Cirrhosis.

Ann Hepatol 2018 Mar;17(2):286-299

Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil. Division of Gastroenterology.

Introduction: Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated with adiponectin and resistin levels and its clinical significance in patients with cirrhosis.

Materials And Methods: This was a prospective cohort study that included 122 subjects with cirrhosis who attended an outpatient clinic and were initially evaluated in 2012. Read More

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March 2018
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TCR Vβ Usage of Peripheral Blood and Liver Infiltrating Lymphocytes in Patients with Chronic Hepatitis B.

Ann Hepatol 2018 Mar;17(2):214-222

Affiliated Hospital of Jining Medical University, China. Clinical Laboratory.

Introduction: Chronic hepatitis B (CHB) is still a public health problem and its mechanism remains unclear. In this study, we detect the skewness of T cell receptor beta chain variable gene (TCR Vβ) in peripheral blood lymphocytes (PBL) and the liver infiltrating lymphocytes (LIL) of patients with CHB; and hope to provide information for further research on the pathogenic mechanism of CHB.

Material And Methods: Fifteen patients with CHB, ten healthy volunteers and three patients with liver cysts were recruited as the subjects. Read More

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March 2018
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