210 results match your criteria Annals of gastroenterological surgery[Journal]


Perioperative antithrombotic management of patients who receive direct oral anticoagulants during gastroenterological surgery.

Ann Gastroenterol Surg 2020 May 1;4(3):301-309. Epub 2020 Apr 1.

Department of Surgery Kokura Memorial Hospital Kitakyushu Japan.

Aim: We investigated the effect of perioperative management of direct oral anticoagulants (DOACs) on bleeding and thromboembolic complications during gastroenterological (GE) surgery.

Methods: A total of 334 patients receiving anticoagulants and undergoing elective GE surgery between 2012 and 2018 were enrolled. The patients were divided into three groups: patients receiving warfarin (WF, n = 231), patients receiving DOACs with heparin bridging (DOAC-HB, n = 34), and patients receiving DOAC without heparin bridging (DOAC-NHB, n = 69). Read More

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http://dx.doi.org/10.1002/ags3.12328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240147PMC

Long-term survival outcomes following laparoscopic surgery for clinical stage 0/I rectal carcinoma.

Ann Gastroenterol Surg 2020 May 20;4(3):294-300. Epub 2020 May 20.

Department of Surgery Kitasato Institute Hospital Kitasato University Tokyo Japan.

Aim: To clarify and evaluate the long-term outcomes of laparoscopic surgery for clinical stage 0/I rectal carcinoma patients.

Methods: This single-arm phase II trial involved accredited surgeons from 43 Japanese institutions. Patients were registered preoperatively. Read More

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http://dx.doi.org/10.1002/ags3.12333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240150PMC

Impact of adherence to board-certified surgeon systems and clinical practice guidelines on colon cancer surgical outcomes in Japan: A questionnaire survey of the National Clinical Database.

Ann Gastroenterol Surg 2020 May 7;4(3):283-293. Epub 2020 Apr 7.

The Japanese Society of Gastroenterological Surgery Tokyo Japan.

Aim: To investigate the effectiveness of the institutional medical structure and of the implemented clinical practice guidelines for improving colon cancer surgical outcomes.

Methods: We conducted a web-based questionnaire survey among departments registered at the National Clinical Database in Japan from October 2014 to January 2015 to assess the association between quality indicators (QIs), including structure and process indicators (clinical practice guideline adherence), and the risk-adjusted odds ratio for operative mortality (AOR) after right hemicolectomy for colorectal cancer during the study period.

Results: Among the 2064 departments registering at least one colorectal surgery during the study period, we obtained responses from 814 departments (39. Read More

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http://dx.doi.org/10.1002/ags3.12327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240142PMC

Prognostic impact of p53 and/or NY-ESO-1 autoantibody induction in patients with gastroenterological cancers.

Ann Gastroenterol Surg 2020 May 25;4(3):275-282. Epub 2020 Mar 25.

Department of Surgery School of Medicine Toho University Tokyo Japan.

Background And Aim: We evaluated the clinicopathological and prognostic significance of serum p53 (s-p53-Abs) and serum NY-ESO-1 autoantibodies (s-NY-ESO-1-Abs) in esophageal squamous cell carcinoma (ESCC), gastric cancer and hepatocellular carcinoma (HCC).

Patients And Methods: A total of 377 patients, 85 patients with ESCC, 248 patients with gastric cancer, and 44 patients with HCC were enrolled to measure s-p53-Abs and s-NY-ESO-1-Abs titers by the enzyme-linked immunosorbent assay before treatment. The clinicopathological significance and prognostic impact of the presence of autoantibodies were evaluated. Read More

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http://dx.doi.org/10.1002/ags3.12325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240143PMC

Surgical outcomes in gastroenterological surgery in Japan: Report of the National Clinical Database 2011-2018.

Ann Gastroenterol Surg 2020 May 20;4(3):250-274. Epub 2020 Mar 20.

The Japanese Society of Gastroenterological Surgery Tokyo Japan.

The National Clinical Database (NCD) of Japan grew rapidly, harvesting over 11 million cases of data between 2011 and 2018 from more than 5000 facilities. This is the Report of the NCD based upon gastrointestinal surgery information in 4 420 175 cases from 2011 to 2018. More than 70% of all gastrointestinal surgeries were performed at certified institutions, and the percentage of surgeries performed at certified institutions was particularly high for the esophagus (93. Read More

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http://dx.doi.org/10.1002/ags3.12324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240139PMC

Advances in the surgical treatment of esophageal cancer since 1965.

Ann Gastroenterol Surg 2020 May 14;4(3):243-249. Epub 2020 Apr 14.

Department of Frontier Surgery Graduate School of Medicine Chiba University Chiba Japan.

In Japan, the treatment of esophageal cancer has undergone significant development since the Japanese Society for Esophageal Diseases was established in 1965 by Doctors Komei Nakayama, Shigetsugu Katsura, and Ichiro Akakura. When the Society was established, surgery was the first-line treatment for esophageal cancer. Since then, the Society has been led by three successive chairpersons-Doctors Katsura, Nakayama, and Satoh. Read More

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http://dx.doi.org/10.1002/ags3.12332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240144PMC

Minimally invasive complete mesocolic excision for right colon cancer.

Ann Gastroenterol Surg 2020 May 7;4(3):234-242. Epub 2020 Apr 7.

Department of Surgery Korea University Anam Hospital Seoul South Korea.

Complete mesocolic excision (CME) with central vascular ligation (CVL) follows the same principles as the total mesorectal excision (TME) in the rectum of following the embryological planes for right-sided cancers. The number of lymph nodes yielded increased with a resultant improvement in the oncological outcomes and by reducing local recurrence rates. Hohenberger's radical CME and CVL and the East's modified CME with D3 lymphadenectomy, which traditionally followed the embryological plane dissection for most of its intraabdominal cancer resection, have both shown to harvest significantly higher number of lymph nodes leading to a higher overall survival rate than the traditional right hemicolectomies of the West. Read More

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http://dx.doi.org/10.1002/ags3.12331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240146PMC

Characteristics of early-onset pancreatic cancer and its association with familial pancreatic cancer and hereditary pancreatic cancer syndromes.

Ann Gastroenterol Surg 2020 May 27;4(3):229-233. Epub 2020 Mar 27.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Osaka Japan.

The incidence of pancreatic cancer is high among those in their sixties to seventies but low in those in their fifties or younger. Although there is no unified definition regarding the age of early-onset pancreatic cancer, previously published reports suggest that, compared to later-onset pancreatic cancer patients, early-onset pancreatic cancer patients tend to be detected at advanced stages and thus have poor prognoses, but they do not show significantly higher rates of patients with genetic factors. On the other hand, it has been reported that patients with familial pancreatic cancer and hereditary pancreatic cancer syndromes often develop pancreatic cancer at a young age. Read More

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http://dx.doi.org/10.1002/ags3.12326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240141PMC

Advanced laparoscopic HPB surgery: Experience in Seoul National University Bundang Hospital.

Ann Gastroenterol Surg 2020 May 25;4(3):224-228. Epub 2020 Mar 25.

Seoul National University Bundang Hospital Gyeonggi-do Korea.

The worldwide trend in surgery has moved from open surgery to minimally invasive surgery. Likewise, the application of minimally invasive surgery in the hepato-pancreato-biliary (HBP) field is also rapidly expanding. The field of HBP surgery can be divided into liver, pancreas and biliary fields. Read More

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http://dx.doi.org/10.1002/ags3.12323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240149PMC

Application of liquid biopsy for surgical management of pancreatic cancer.

Ann Gastroenterol Surg 2020 May 12;4(3):216-223. Epub 2020 Feb 12.

Department of Surgery Nara Medical University Kashihara Japan.

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer. Although drug development over the past decade has gradually improved the prognosis of PDAC, the prognosis remains extremely poor. The predominant determinant of a poor prognosis is that patients are already at the advanced stage when they are diagnosed. Read More

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http://dx.doi.org/10.1002/ags3.12317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240145PMC

Evolving thresholds for liver transplantation in hepatocellular carcinoma: A Western experience.

Ann Gastroenterol Surg 2020 May 11;4(3):208-215. Epub 2020 Feb 11.

Division of Surgical Oncology Department of Surgery University of Texas Southwestern Medical Center Dallas Texas.

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Once considered an experimental treatment with dismal survival rates, liver transplantation for HCC entered a new era with the establishment of the Milan criteria over 20 years ago. In the modern post-Milan-criteria era, 5-year survival outcomes are now upwards of 70% in select patients. Read More

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http://dx.doi.org/10.1002/ags3.12316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240148PMC

Essential updates 2018/2019: Liver transplantation.

Ann Gastroenterol Surg 2020 May 25;4(3):195-207. Epub 2020 Feb 25.

Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan.

Among the recent topics in the field of liver transplantation (LT), one of the significant therapeutic breakthroughs is the introduction of direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) infection. With cure rates close to 100%, a better proportion of LT candidates and recipients can be cured of HCV infection by DAA therapies that are simple and well-tolerated. Other critical topics include the issue of indication of LT for patients with hepatocellular carcinoma, which has been continuously studied. Read More

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http://dx.doi.org/10.1002/ags3.12321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240140PMC

Essential Updates 2018/2019: Essential Updates for esophageal cancer surgery.

Authors:
Yasuyuki Seto

Ann Gastroenterol Surg 2020 May 18;4(3):190-194. Epub 2020 Feb 18.

Department of Gastrointestinal Surgery Graduate School of Medicine The University of Tokyo Tokyo Japan.

Key papers to treatment of esophageal cancer surgery and reduction of postoperative complications after esophagectomy published between 2018 and 2019 were reviewed. Within this review there was a focus on minimally invasive esophagectomy (MIE), robot-assisted MIE (RAMIE), and centralization to high-volume center. Advantages of MIE, irrespectively of hybrid or total MIE, to prevent postoperative complications, especially pneumonia, were shown in comparison to open procedure. Read More

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http://dx.doi.org/10.1002/ags3.12319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240138PMC

Why minimally invasive surgery for esophageal cancer is minimally invasive?

Authors:
Naoki Hiki

Ann Gastroenterol Surg 2020 May 14;4(3):188-189. Epub 2020 May 14.

Department of Upper Gastrointestinal Surgery Kitasato University School of Medicine Kanagawa Japan.

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http://dx.doi.org/10.1002/ags3.12346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240137PMC

Developing an in vivo porcine model of duct-to-mucosa pancreaticojejunostomy (Yonsei-PJ).

Ann Gastroenterol Surg 2020 Mar 28;4(2):180-184. Epub 2020 Jan 28.

Division of Hepatobiliary and Pancreatic Surgery Yonsei University College of Medicine Seoul Korea.

Laparoscopic pancreaticoduodenectomy (LPD) is technically feasible, but its safety is still controversial. Pancreas texture and the small size of the main pancreatic duct indicate laparoscopic pancreaticoduodenectomy (LPD) as a challenging procedure. Thus, LPD could be a risk factor for postoperative pancreatic fistula (POPF), longer hospital stay, and delayed adjuvant chemotherapy that affects long-term oncologic outcome. Read More

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http://dx.doi.org/10.1002/ags3.12310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105835PMC

Two-in-one method: Novel pancreaticojejunostomy technique for the bifid pancreas.

Ann Gastroenterol Surg 2020 Mar 23;4(2):175-179. Epub 2019 Dec 23.

Division of Hepato-Biliary-Pancreatic Surgery Department of Surgery Kobe University Graduate School of Medicine Kobe Japan.

The bifid pancreas is a rare anatomical variation of the pancreatic duct in which double main pancreatic ducts in the body and tail of the pancreas join at the pancreas head and drain through the major papilla. When pancreaticoduodenectomies are carried out on bifid pancreases, close attention must be paid to the reconstruction because of the possibility that there may be two pancreatic ducts that need to be reconstructed. We present a case of pancreaticoduodenectomy for the bifid pancreas and a novel technique named the 'two-in-one' method for double pancreatic duct to jejunum anastomosis. Read More

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http://dx.doi.org/10.1002/ags3.12302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105849PMC

Segment IV approach for difficult laparoscopic cholecystectomy.

Ann Gastroenterol Surg 2020 Mar 11;4(2):170-174. Epub 2019 Nov 11.

Department of Surgery The Jikei University School of Medicine Tokyo Japan.

Although achieving the critical view of safety (CVS) is useful for avoiding vasculobiliary injury during laparoscopic cholecystectomy (LC), the CVS cannot always be achieved in cases of severe cholecystitis because of technical difficulties. Herein, we focused on segment IV of the liver and its diagonal line (D-line) as a feasible landmark for carrying out difficult LC. The D-line connects the right dorsal and left ventral corners of segment IV and is used as the vectoral landmark, which is where the gallbladder is first dissected to achieve CVS without misidentification. Read More

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http://dx.doi.org/10.1002/ags3.12297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105843PMC

Clinical impact of D3 lymph node dissection with left colic artery (LCA) preservation compared to D3 without LCA preservation: Exploratory subgroup analysis of data from JCOG0404.

Ann Gastroenterol Surg 2020 Mar 26;4(2):163-169. Epub 2020 Feb 26.

Gastroenterological and Pediatric Surgery Oita University of Faculty of Medicine Yufu Japan.

Aim: We investigated the clinical impact of D3 lymph node dissection preserving left colic artery (LCA) compared to D3 without LCA preservation using data from JCOG0404. LCA preservation is expected to maintain adequate blood supply, which is effective in preventing anastomotic leakage, intestinal paralysis, and bowel obstruction. Whether D3 with LCA preservation (Group A) improves clinical outcomes following resection of sigmoid colon cancer compared to D3 without LCA preservation (Group B) is unclear. Read More

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http://dx.doi.org/10.1002/ags3.12318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105844PMC

Laparoscopic transabdominal preperitoneal repair versus open mesh plug repair for bilateral primary inguinal hernia.

Ann Gastroenterol Surg 2020 Mar 11;4(2):156-162. Epub 2020 Feb 11.

Department of Surgery Ogaki Municipal Hospital Ogaki-shi Japan.

Aim: A few studies comparing laparoscopic and open techniques have reported that open repair with mesh is the optimal operation for unilateral primary hernia. The aim of this study is to compare the outcomes of laparoscopic transabdominal preperitoneal repair (TAPP) versus open mesh plug repair (MP) for bilateral primary inguinal hernia.

Methods: This was a retrospective study of 107 patients with bilateral primary inguinal hernia between January 2008 and December 2016. Read More

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http://dx.doi.org/10.1002/ags3.12314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105845PMC

Bevacizumab-associated intestinal perforation and perioperative complications in patients receiving bevacizumab.

Ann Gastroenterol Surg 2020 Mar 12;4(2):151-155. Epub 2020 Feb 12.

Department of Surgery Tokushima University Tokushima Japan.

Aim: The purposes of this study are to present cases of emergency surgery in which gastrointestinal perforation occurred during bevacizumab administration, consider the indications for emergency surgery, and examine the safety of scheduled surgery after a washout period for bevacizumab.

Methods: (a) We retrospectively investigated seven patients who underwent emergency surgery for bevacizumab-associated intestinal perforation. (b) We investigated 104 patients with advanced colorectal cancer treated with neoadjuvant therapy who underwent surgery from 2008 to 2018, retrospectively. Read More

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http://dx.doi.org/10.1002/ags3.12312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105838PMC

Billroth-I vs Roux-en-Y after distal gastrectomy: A comparison of long-term nutritional status and survival rates from a large-scale multicenter cohort study.

Ann Gastroenterol Surg 2020 Mar 4;4(2):142-150. Epub 2020 Feb 4.

Department of Surgery Kitasato University Sagamihara Japan.

Background: The optimal standard reconstruction procedure after distal gastrectomy is controversial. No large-scale persuasive clinical studies from long-term perspectives on this topic have yet been conducted.

Study Design: This retrospective multicenter study analyzed a database of 2510 consecutive patients with clinical stage I gastric cancer who underwent distal gastrectomy followed by Billroth-I (B-I) or Roux-en-Y (R-Y) anastomosis from 2006 to 2012. Read More

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http://dx.doi.org/10.1002/ags3.12309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105836PMC

Caspase recruitment domain family member 9 expression is a promising biomarker in esophageal squamous cell carcinoma.

Ann Gastroenterol Surg 2020 Mar 22;4(2):135-141. Epub 2019 Dec 22.

Department of Frontier Surgery Graduate School of Medicine Chiba University Chiba Japan.

Aim: Esophageal squamous cell carcinoma (ESCC) is a refractory digestive organ cancer that requires better treatment strategies. We have recently reported that the antidiabetic drug metformin exerts antitumor effects on ESCC by inhibition of nuclear factor kappa B (NF-κB) nuclear translocation. In the present study, we focused on caspase recruitment domain family member 9 (CARD9), an essential signal adapter in NF-κB activation to examine whether it can be used as a prognostic factor in ESCC. Read More

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http://dx.doi.org/10.1002/ags3.12305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105841PMC

Postoperative complications of minimally invasive esophagectomy for esophageal cancer.

Ann Gastroenterol Surg 2020 Mar 12;4(2):126-134. Epub 2020 Feb 12.

Department of Gastroenterological Surgery Tokai University School of Medicine Kanagawa Japan.

Minimally invasive esophagectomy (MIE) has been performed increasingly more frequently for the treatment of esophageal cancer, ever since it was first described in 1992. However, the incidence of postoperative complications of MIE has not yet been well-characterized, because (a) there are few reports of studies with a sufficient sample size, (b) a variety of minimally invasive surgical techniques are used, and (c) there are few reports in which an established system for classifying the severity of complications is examined. According to an analysis performed by the Esophageal Complications Consensus Group, the most common complications of MIE are pneumonia, arrhythmia, anastomotic leakage, conduit necrosis, chylothorax, and recurrent laryngeal nerve palsy. Read More

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http://dx.doi.org/10.1002/ags3.12315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105848PMC

History of pancreatic surgery in Japan: Respect to the Japanese pioneers of pancreatic surgery.

Authors:
Hiroki Yamaue

Ann Gastroenterol Surg 2020 Mar 4;4(2):118-125. Epub 2020 Mar 4.

Second Department of Surgery Wakayama Medical University Wakayama Japan.

The first report of pancreatoduodenectomy was the abstract of Japan Surgical Society in 1946 by Kuru, followed by a publication by Yoshioka (Geka, 1950). The first report of total pancreatectomy was done by Honjo in 1950 (Shujutsu). Thus, the history of pancreatic surgery in Japan dawned in the 1950s. Read More

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http://dx.doi.org/10.1002/ags3.12320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105840PMC

The history of liver surgery: Achievements over the past 50 years.

Ann Gastroenterol Surg 2020 Mar 26;4(2):109-117. Epub 2020 Feb 26.

Department of Surgery National Center for Global Health and Medicine Tokyo Japan.

We reviewed the progress made in the field of liver surgery over the past 50 years. The widespread use and improved outcomes of the hepatectomy were, primarily, due to pioneer surgeons who were responsible for technological advances and rapid improvements in the safety of the procedure in the last century. These advances included the hepatic functional evaluation used to determine the safety limit of liver resections, the introduction of intraoperative ultrasonography, and the development of innovative techniques such as portal vein embolization to increase the remnant liver volume. Read More

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http://dx.doi.org/10.1002/ags3.12322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105847PMC

Neoadjuvant treatment for resectable pancreatic adenocarcinoma: What is the best protocol?

Ann Gastroenterol Surg 2020 Mar 18;4(2):100-108. Epub 2020 Feb 18.

Department of Surgery Tohoku University Graduate School of Medicine Aoba-ku Japan.

Although upfront surgery has been the gold standard for pancreatic adenocarcinoma that is planned for resection, it should be compared with the alternative strategy of neoadjuvant therapy. Despite the many reports of the efficacy of neoadjuvant therapy, most of them were not comparative. Recently Prep-02/JSAP05 study clearly demonstrated the significant survival benefit of neoadjuvant chemotherapy over upfront surgery for pancreatic adenocarcinoma that is planned for resection. Read More

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http://dx.doi.org/10.1002/ags3.12311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105839PMC

Recent advances in hepato-biliary-pancreatic surgery.

Ann Gastroenterol Surg 2020 Mar 31;4(2):98-99. Epub 2020 Mar 31.

Department of Gastroenterology Fujita Health University School of Medicine Bantane Hospital Nagoya Japan.

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http://dx.doi.org/10.1002/ags3.12330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105837PMC

Exosomal microRNA in peritoneal fluid as a biomarker of peritoneal metastases from gastric cancer.

Ann Gastroenterol Surg 2020 Jan 6;4(1):84-93. Epub 2019 Nov 6.

Center for Clinical Research Jichi Medical University Hospital Shimotsuke Japan.

Aim: Peritoneal metastases (PM) frequently occur in patients with gastric cancer and result in a poor prognosis. Exosomes play pivotal roles in tumor metastasis through the transfer of microRNAs (miRNAs). We examined the exosomal miRNA profile in peritoneal fluids to identify novel biomarkers to reflect tumor burden in the peritoneum. Read More

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http://dx.doi.org/10.1002/ags3.12296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992685PMC
January 2020

Glucocorticoid use and ischemia-reperfusion injury in laparoscopic liver resection: Randomized controlled trial.

Ann Gastroenterol Surg 2020 Jan 19;4(1):76-83. Epub 2019 Nov 19.

Department of Surgery Iwate Medical University School of Medicine Morioka City Japan.

Aim: Laparoscopic liver resection (LLR) is increasingly carried out worldwide. However, there are concerns regarding ischemia-reperfusion injury caused by pneumoperitoneum and the Pringle maneuver. It is not clear whether perioperative use of glucocorticoids lowers the risk of ischemia-reperfusion hepatic injury in LLR as has been reported for open liver resection. Read More

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http://dx.doi.org/10.1002/ags3.12298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992679PMC
January 2020

Postoperative non-steroidal anti-inflammatory drugs and anastomotic leakage after gastrointestinal anastomoses: Systematic review and meta-analysis.

Ann Gastroenterol Surg 2020 Jan 2;4(1):64-75. Epub 2019 Dec 2.

Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery Nippon Medical School Tokyo Japan.

Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to control postoperative pain; however, their postoperative use has been associated with anastomotic leakage after gastrointestinal surgery. This systematic review and meta-analysis aimed to determine the correlation between the use of NSAIDs and anastomotic leakage.

Methods: We conducted a comprehensive electronic literature search up to August 2018 to identify studies comparing anastomotic leakage in patients with and without postoperative NSAID use following gastrointestinal surgery. Read More

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http://dx.doi.org/10.1002/ags3.12300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992684PMC
January 2020

Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta-analysis.

Ann Gastroenterol Surg 2020 Jan 21;4(1):56-63. Epub 2019 Oct 21.

Department of Surgery National Defense Medical College Tokorozawa Japan.

Aim: Impact of several immune-inflammatory markers on long-term outcome has been reported in various malignancies. The aim of the present study was to evaluate through a meta-analysis the oncological outcome of immune-inflammatory markers, such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and C-reactive protein to albumin ratio (CAR) in esophageal cancer.

Methods: A systematic electronic search for relevant studies was carried out in PubMed, Cochrane library, Embase, and Google scholar. Read More

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http://dx.doi.org/10.1002/ags3.12294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992676PMC
January 2020

Treatment strategy for isolated bile leakage after hepatectomy: Literature review.

Ann Gastroenterol Surg 2020 Jan 5;4(1):47-55. Epub 2019 Dec 5.

Department of Hepatobiliary and Pancreatic Surgery Gunma University Graduate School of Medicine Maebashi Japan.

Isolated bile leakage (IBL) after hepatectomy is intractable, and various treatment methods for it have been reported. This review aimed to clarify the treatment strategy for IBL by summarizing studies on IBL after hepatectomy without extrahepatic bile duct resection. Thirty-three cases of IBL were reported. Read More

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http://dx.doi.org/10.1002/ags3.12303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992677PMC
January 2020

Essential advances in surgical and adjuvant therapies for colorectal cancer 2018-2019.

Ann Gastroenterol Surg 2020 Jan 28;4(1):39-46. Epub 2020 Jan 28.

Department of Gastroenterological and Pediatric Surgery Faculty of Medicine Oita University Yufu-City Japan.

Surgical resection and adjuvant chemotherapy are the only treatment modalities for localized colorectal cancer that can obtain a "cure." The goal in surgically treating primary colorectal cancer is complete tumor removal along with dissection of systematic D3 lymph nodes. Adjuvant treatment controls recurrence and improves the prognosis of patients after they undergo R0 resection. Read More

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http://dx.doi.org/10.1002/ags3.12307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992683PMC
January 2020

Essential updates 2018/2019: Colorectal (benign): Recent updates (2018-2019) in the surgical treatment of benign colorectal diseases.

Ann Gastroenterol Surg 2020 Jan 16;4(1):30-38. Epub 2019 Dec 16.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Osaka Japan.

This review outlines current topics on the surgical treatment of benign colorectal diseases, with a focus on inflammatory bowel disease (IBD) and diverticulitis. Treatment options for IBD and diverticulitis have evolved in the last few years as a result of medical advances in technology and new clinical trials. Therefore, treatment options and strategies need to be updated to provide optimal care for patients. Read More

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http://dx.doi.org/10.1002/ags3.12304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992682PMC
January 2020

Progress in the treatment of gastric cancer in Japan over the last 50 years.

Authors:
Mitsuru Sasako

Ann Gastroenterol Surg 2020 Jan 30;4(1):21-29. Epub 2020 Jan 30.

Yodogawa Christian Hospital Osaka Japan.

There have been remarkable changes in gastric cancer treatments in Japan, resulting in superb improvement of prognosis in patients with this disease. In this paper, the last 50 years have been divided into three eras: before 1990; the 1990s; and the era of evidence, which means after 2000. Changes of treatments and prognosis were analyzed by several factors, such as surgery, chemotherapy, informed consent, clinical trials, and others, as improvement of prognosis is not due to one factor but several ones influencing each other. Read More

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http://dx.doi.org/10.1002/ags3.12306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992673PMC
January 2020

Effects of specific nutrients on immune modulation in patients with gastrectomy.

Ann Gastroenterol Surg 2020 Jan 9;4(1):14-20. Epub 2019 Dec 9.

Department of Surgery National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan.

Gastric cancer (GC) is one of the most prevalent and lethal malignant neoplasms worldwide. The main treatment for GC is gastrectomy, which generally causes considerable metabolic stress to patients. To modulate cell function, maintain homeostasis of the immune response, reduce postoperative complications, and obtain favorable outcomes, physicians prescribe specific nutrients with immunomodulatory properties as supplementation to enteral or parenteral formulas, indicating immunonutrition. Read More

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http://dx.doi.org/10.1002/ags3.12299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992678PMC
January 2020

Surgical indication for and desirable outcomes of conversion surgery in patients with initially unresectable pancreatic ductal adenocarcinoma.

Ann Gastroenterol Surg 2020 Jan 29;4(1):6-13. Epub 2019 Oct 29.

Department of Surgery Kansai Medical University Hirakata-City Japan.

Aim of this review is to propose an acceptable surgical indication for conversion surgery in patients with initially unresectable (UR) pancreatic ductal adenocarcinoma (PDAC) by considering desirable outcomes, including resectability, overall survival (OS), and disease-free survival (DFS). A comprehensive literature search of PubMed was conducted through July 15, 2019. Eligible studies were those reporting on patients with UR-PDAC who underwent surgery. Read More

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http://dx.doi.org/10.1002/ags3.12295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992681PMC
January 2020

The time has come for Japanese surgeons to work in English.

Authors:
Hiroaki Nagano

Ann Gastroenterol Surg 2020 Jan 30;4(1). Epub 2020 Jan 30.

Department of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Yamaguchi Japan.

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http://dx.doi.org/10.1002/ags3.12313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992674PMC
January 2020

Towards further promotion of .

Authors:
Masaki Mori

Ann Gastroenterol Surg 2020 Jan 30;4(1). Epub 2020 Jan 30.

Department of Surgery and Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan.

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http://dx.doi.org/10.1002/ags3.12308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992680PMC
January 2020

Pathological complete response (pCR) with or without the residual intraductal carcinoma component following preoperative treatment for pancreatic cancer: Revisiting the definition of "pCR" from the prognostic standpoint.

Ann Gastroenterol Surg 2019 Nov 20;3(6):676-685. Epub 2019 Sep 20.

Department of Gastroenterological surgery Osaka International Cancer Institute Osaka Japan.

Background And Aim: There are no previous reports describing the prognostic significance of the residual intraductal carcinoma component (carcinoma in situ [CIS]) following preoperative treatment for pancreatic ductal adenocarcinoma (PDAC). The aim of the present study was to investigate the prognostic significance of a minimal residual CIS in cases with complete absence of an invasive component after preoperative treatment for PDAC.

Methods: Eighty-one of 594 PDAC patients with preoperative treatment and subsequent surgery in our institute showed remarkable remission in the invasive component, which included 48 patients with the minimal residual invasive component (Min-inv group) and 33 with absence of an invasive component (No-inv group). Read More

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http://dx.doi.org/10.1002/ags3.12288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875936PMC
November 2019

Verification of inflammation-based prognostic marker as a prognostic indicator in hepatocellular carcinoma.

Ann Gastroenterol Surg 2019 Nov 20;3(6):667-675. Epub 2019 Sep 20.

Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Science Hiroshima University Hiroshima Japan.

Aim: Although inflammation-based markers in cancer have been used for prognostic prediction, the most useful marker for hepatocellular carcinoma (HCC) has not been established. We investigated the usefulness of various inflammation-based markers in HCC patients after hepatectomy.

Methods: A total of 478 patients who underwent initial hepatectomy for HCC from 2009 to 2015 and were diagnosed with pathological HCC were included in this retrospective study. Read More

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http://dx.doi.org/10.1002/ags3.12286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875930PMC
November 2019

Visceral obesity is a preoperative risk factor for postoperative ileus after surgery for colorectal cancer: Single-institution retrospective analysis.

Ann Gastroenterol Surg 2019 Nov 16;3(6):657-666. Epub 2019 Oct 16.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Osaka Japan.

Aim: Visceral obesity (VO) reportedly has a stronger association with complications after colorectal surgery than does body mass index. Here, we retrospectively assessed VO as a risk factor for postoperative ileus (POI) after colorectal resection in patients with colorectal cancer.

Methods: This study included 417 consecutive patients with colorectal cancer who underwent elective surgery at our institute from January 2010 to December 2012. Read More

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http://dx.doi.org/10.1002/ags3.12291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876266PMC
November 2019

Long-term effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients (KSES002).

Ann Gastroenterol Surg 2019 Nov 10;3(6):648-656. Epub 2019 Oct 10.

Department of Surgery Toyonaka Municipal Hospital Toyonaka Japan.

Aim: The present study aimed to evaluate the efficacy of short-term nutritional intervention with an oral elemental diet (ED; Elental; EA Pharma Co., Ltd, Tokyo, Japan) at 300 kcal/day for 6-8 weeks in the early post-gastrectomy period on postoperative long-term body weight loss (BWL).

Methods: We analyzed consecutive patients who were randomly divided to receive the regular diet with or without ED. Read More

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http://dx.doi.org/10.1002/ags3.12290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875942PMC
November 2019

Background characteristics and postoperative outcomes of insufficient weight loss after laparoscopic sleeve gastrectomy in Japanese patients.

Ann Gastroenterol Surg 2019 Nov 26;3(6):638-647. Epub 2019 Aug 26.

Center of Diabetes, Endocrine and Metabolism Toho University Sakura Medical Center Chiba Japan.

Aim: Laparoscopic sleeve gastrectomy (LSG) is becoming popular in Japan, but insufficient weight loss is often observed in patients after LSG. We investigated the effect of LSG on obesity-related comorbidities and identified the background characteristics of Japanese patients with insufficient weight loss after LSG.

Methods: In this multi-institutional retrospective study at 10 certified bariatric institutions, 322 Japanese patients who underwent LSG with a follow-up period of more than 2 years were analyzed. Read More

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http://dx.doi.org/10.1002/ags3.12285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875950PMC
November 2019

Sarcopenia discriminates poor prognosis in elderly patients following emergency surgery for perforation panperitonitis.

Ann Gastroenterol Surg 2019 Nov 16;3(6):630-637. Epub 2019 Aug 16.

Department of Surgery Beppu Medical Center National Hospital Organization Beppu Japan.

Aim: Sarcopenia has been reported as a prognostic predictor in various conditions; however, it has not been examined in patients with perforation panperitonitis.

Methods: A total of 103 consecutive patients with perforation panperitonitis who underwent emergency surgery from 2008 to 2016 were retrospectively evaluated. Skeletal muscle index (SMI) was measured as the cross-sectional area (cm) of skeletal muscle in the L3 region on computed tomography images normalized for height (cm/m). Read More

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http://dx.doi.org/10.1002/ags3.12281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875939PMC
November 2019

Current evidence of nutritional therapy in pancreatoduodenectomy: Systematic review of randomized controlled trials.

Ann Gastroenterol Surg 2019 Nov 10;3(6):620-629. Epub 2019 Oct 10.

Department of Surgery Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.

Aim: Evidence of nutritional therapies in pancreatoduodenectomy (PD) has been shown. However, few studies focus on the association between different nutritional therapies and outcomes. The aim of this review was to summarize the current evidence of nutritional therapies such as enteral nutrition (EN), immunonutrition, and synbiotics on postoperative outcomes after PD. Read More

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http://dx.doi.org/10.1002/ags3.12287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875945PMC
November 2019

Current role of trisectionectomy for hepatopancreatobiliary malignancies.

Ann Gastroenterol Surg 2019 Nov 22;3(6):606-619. Epub 2019 Oct 22.

Department of HPB and Transplant Surgery St. James's University Hospital Leeds UK.

Background: Trisectionectomy is a treatment option in extensive liver malignancy, including colorectal liver metastases (CRLM). However, the reported experience of this procedure is limited. Therefore, we present our experience with right hepatic trisectionectomy (RHT) for CRLM as an example and discuss the changing role of trisectionectomy in the context of modern treatment alternatives based on a literature review. Read More

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http://dx.doi.org/10.1002/ags3.12292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875946PMC
November 2019

Fifty-year history of biliary surgery.

Authors:
Masato Nagino

Ann Gastroenterol Surg 2019 Nov 30;3(6):598-605. Epub 2019 Sep 30.

Division of Surgical Oncology Department of Surgery Nagoya University Graduate School of Medicine Nagoya Japan.

There has been enormous progress in the surgical treatment of biliary tract cancers in the past 50 years. In preoperative management, biliary drainage methods have changed from percutaneous transhepatic biliary drainage to endoscopic nasobiliary drainage, while the advent of multidetector-row computed tomography in imaging diagnostics now enables visualization of three-dimensional anatomy, extent of cancer progression, and hepatic segment volume. Portal vein embolization has also greatly improved the safety of extended hepatectomy, and indication of extended hepatectomy can now be objectively determined with a combination of the indocyanine green test and computed tomography volumetry. Read More

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http://dx.doi.org/10.1002/ags3.12289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875948PMC
November 2019

Controversies in preoperative therapy in esophageal cancer: Current evidence and ongoing research.

Ann Gastroenterol Surg 2019 Nov 25;3(6):592-597. Epub 2019 Nov 25.

Division of Thoracic Surgery Department of Surgical Oncology Tata Memorial Hospital Tata Memorial Centre, Homi Bhabha National Institute Mumbai India.

Esophageal cancer incidence is growing worldwide, especially adenocarcinomas in the western world. Outcomes overall are universally poor, with the best survival seen in earlier stages of the disease, where surgery is the mainstay of treatment. Although squamous cell cancers and adenocarcinomas of the esophagus have different etiology, clinical features, biological behavior and prognosis, earlier research studies have frequently combined the two histologies. Read More

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http://dx.doi.org/10.1002/ags3.12301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875935PMC
November 2019

Essential updates 2017/2018: Recent topics in the treatment and research of gastric cancer in Japan.

Ann Gastroenterol Surg 2019 Nov 27;3(6):581-591. Epub 2019 Aug 27.

Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine Kyoto Japan.

Recent developments in diagnostic technology, accumulated clinical effort and established evidence have boosted early detection and drastically improved early and long-term outcomes of gastric cancer. However, gastric cancer continues to be one of the most aggressive and life-threatening malignancies among all cancers and is a global health problem. Between January 2017 and December 2018, various fascinating reports of managements and research were published, including the new 15th Japanese Classification of Gastric Carcinoma reflecting the 8th American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor, node and metastasis (TNM) classification (October 2017) and the new Gastric Cancer Treatment Guidelines version 5 (January 2018). Read More

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http://dx.doi.org/10.1002/ags3.12284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875932PMC
November 2019