120 results match your criteria Annals of gastroenterological surgery[Journal]


Long-term outcomes after biliary diversion operation for pancreaticobiliary maljunction in adult patients.

Ann Gastroenterol Surg 2019 Mar 19;3(2):217-223. Epub 2019 Feb 19.

Department of Pediatric Surgery Osaka City University Graduate School of Medicine Osaka Japan.

Aim: Pancreaticobiliary maljunction (PBM) with or without congenital biliary dilatation (CBD) is a risk factor for biliary tract cancer. We investigated long-term outcomes after biliary diversion operation with special reference to types of CBD.

Methods: Subjects comprised 40 adult patients who underwent biliary diversion operation for PBM without biliary tract cancer. Read More

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http://dx.doi.org/10.1002/ags3.12239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422791PMC
March 2019
1 Read

Comparison of the long-term outcomes of the self-expandable metallic stent and transanal decompression tube for obstructive colorectal cancer.

Ann Gastroenterol Surg 2019 Mar 29;3(2):209-216. Epub 2019 Jan 29.

Department of Gastroenterological Surgery Sendai City Medical Center Sendai Open Hospital Sendai Japan.

Aim: Endoscopic decompression using the self-expandable metallic colonic stent (SEMS) or transanal decompression tube (TDT) can convert emergency surgery into elective one-stage surgery for obstructive colorectal cancer (OCRC). The aim of the present study was to clarify the effect of SEMS and TDT on long-term oncological outcomes.

Methods: We retrospectively analyzed 76 consecutive pathological stage II and III OCRC patients who were inserted with SEMS or TDT as a bridge to curative surgery between 2009 and 2018. Read More

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http://dx.doi.org/10.1002/ags3.12235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422834PMC

Risk factors for incisional surgical site infection after elective laparoscopic colorectal surgery.

Ann Gastroenterol Surg 2019 Mar 11;3(2):202-208. Epub 2019 Jan 11.

Department of Gastroenterological Surgery Graduate School of Medicine Yokohama City University Yokohama Japan.

Background: Surgical site infection (SSI) is a common morbidity in patients undergoing colorectal surgery, and the focus of previous studies has primarily been on incisional SSI. Most reports thus far have focused on open surgery rather than on laparoscopic colorectal surgery (Lap CR). Therefore, the aim of the present study was to identify the risk factors for incisional SSI in patients undergoing elective Lap CR. Read More

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http://dx.doi.org/10.1002/ags3.12229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422835PMC
March 2019
1 Read

Diagnostic impact of high serum midkine level in patients with gastric cancer.

Ann Gastroenterol Surg 2019 Mar 8;3(2):195-201. Epub 2019 Jan 8.

Department of Surgery School of Medicine Toho University Tokyo Japan.

Aim: We evaluated the diagnostic impact of serum midkine (s-MK) levels in patients with gastric cancer using a monoclonal antibody enzyme-linked immunosorbent assay system (ELISA) to detect s-MK levels.

Methods: Serum samples were obtained from 131 patients with gastric cancer including stage I (n = 71), stage II (n = 28), stage III (n = 16), and stage IV (n = 16) before surgery. Serum samples were analyzed using ELISA to detect soluble midkine. Read More

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http://dx.doi.org/10.1002/ags3.12226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422803PMC

Gastrografin reduces the need for additional surgery in postoperative small bowel obstruction patients without long tube insertion: A meta-analysis.

Ann Gastroenterol Surg 2019 Mar 17;3(2):187-194. Epub 2018 Dec 17.

Department of Gastroenterological Surgery Dokkyo Medical University Tochigi Japan.

Background: Small bowel obstruction (SBO) is a well-known major postoperative complication requiring immediate diagnosis and treatment to avoid additional invasive surgical procedures. Water-soluble contrast medium is often given not only for diagnosis but also for treatment. Although numerous studies have investigated the significance of this treatment, no consensus has yet been established regarding its indications and efficacy. Read More

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http://dx.doi.org/10.1002/ags3.12223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422814PMC

Short-term clinical outcomes of laparoscopic gastrectomy for remnant gastric cancer: A single-institution experience and systematic review of the literature.

Ann Gastroenterol Surg 2019 Mar 3;3(2):181-186. Epub 2018 Nov 3.

Department of Frontier Surgery Graduate School of Medicine Chiba University Chiba Japan.

Aim: Application of laparoscopic approaches for the treatment of remnant gastric cancers (RGC) is still controversial. Therefore, in the present study, the safety and effectiveness of laparoscopic gastrectomy (LG) for RGC was investigated.

Methods: A total of 27 patients who underwent gastrectomy for RGC from June 2008 to September 2017 were enrolled in this study. Read More

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http://dx.doi.org/10.1002/ags3.12221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422809PMC

Treatment and clinical outcome of clinical T4 esophageal cancer: A systematic review.

Ann Gastroenterol Surg 2019 Mar 13;3(2):169-180. Epub 2018 Dec 13.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Osaka Japan.

Background: Survival of patients with cT4 esophageal cancer is dismal. Although the optimal treatment strategy remains to be established, two treatment options are available for cT4 esophageal cancers: definitive chemoradiation (dCRT) and induction treatment followed by conversion surgery (CS). However, little is known concerning the differences in clinical outcome between patients with T4 esophageal tumors treated with dCRT and those eventually treated with CS. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ags3.12222
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http://dx.doi.org/10.1002/ags3.12222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422802PMC
March 2019
3 Reads

Role of nutrition in gastroenterological surgery.

Authors:
Kazuhiko Fukatsu

Ann Gastroenterol Surg 2019 Mar 25;3(2):160-168. Epub 2019 Feb 25.

Surgical Center The University of Tokyo Hospital Tokyo Japan.

Nutrition plays important roles in recovery after gastroenterological surgery. Severe surgical stress increases muscle breakdown and lipolysis, thereby accelerating wound healing and enhancing host defense against microbes. Malnourished patients have insufficient amounts of muscle and body fat. Read More

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http://dx.doi.org/10.1002/ags3.12237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422822PMC
March 2019
1 Read

Current topics in liver surgery.

Ann Gastroenterol Surg 2019 Mar 15;3(2):146-159. Epub 2019 Feb 15.

Department of Digestive Surgery Nihon University School of Medicine Tokyo Japan.

Liver resection is one of the main treatment strategies for liver malignancies. Mortality and morbidity of liver surgery has improved significantly with progress in selection criteria, development of operative procedures and improvements in perioperative management. Safe liver resection has thus become more available worldwide. Read More

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http://dx.doi.org/10.1002/ags3.12233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422805PMC

Current status of minimally invasive esophagectomy for esophageal cancer: Is it truly less invasive?

Ann Gastroenterol Surg 2019 Mar 26;3(2):138-145. Epub 2018 Dec 26.

Division of Gastrointestinal Surgery Department of Surgery Graduate School of Medicine Kobe University Kobe Japan.

Esophagectomy with extended lymphadenectomy remains the mainstay of treatment for localized esophageal cancer. However, it is one of the most invasive procedures with high morbidity. To reduce invasiveness, minimally invasive esophagectomy (MIE), which includes thoracoscopic, laparoscopic, mediastinoscopic, and robotic surgery, is becoming popular worldwide. Read More

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http://dx.doi.org/10.1002/ags3.12224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422792PMC
March 2019
1 Read

Role of the tumor microenvironment in pancreatic cancer.

Ann Gastroenterol Surg 2019 Mar 4;3(2):130-137. Epub 2019 Jan 4.

Department of Gastroenterological Surgery Yokohama City University Graduate School of Medicine Yokohama Japan.

Pancreatic cancer remains a highly recalcitrant disease despite the development of systemic chemotherapies. New treatment options are thus urgently required. Dense stromal formation, so-called "desmoplastic stroma," plays controversial roles in terms of pancreatic cancer growth, invasion, and metastasis. Read More

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http://dx.doi.org/10.1002/ags3.12225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422798PMC

Re-emerging role of macroscopic appearance in treatment strategy for gastric cancer.

Ann Gastroenterol Surg 2019 Mar 19;3(2):122-129. Epub 2018 Oct 19.

Department of Surgery Kitasato University School of Medicine Sagamihara Japan.

Pathological outcomes are definitely the most important prognostic factors in gastric cancer, but they can be obtained only after surgical resection. Use of preoperative adjuvant chemotherapy is becoming widespread for aggressive human cancer, so clinical factors such as macroscopic features are important as they are highly predictive for patient prognosis. In gastric cancer, the macroscopic type represents a distinct prognosis; Type 0 represents early gastric cancer with excellent prognosis, but, among advanced tumors, giant Type III and Type IV tumors have a dismal prognosis. Read More

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http://dx.doi.org/10.1002/ags3.12218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422795PMC
March 2019
10 Reads

Cancer stroma-targeting therapy: A new tool for fighting pancreatic cancer?

Authors:
Kenichi Hakamada

Ann Gastroenterol Surg 2019 Mar 1;3(2):120-121. Epub 2019 Mar 1.

Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Hirosaki Japan.

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http://dx.doi.org/10.1002/ags3.12244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422821PMC

Comparison of the modified Collard and hand-sewn anastomosis for cervical esophagogastric anastomosis after esophagectomy in esophageal cancer patients: A propensity score-matched analysis.

Ann Gastroenterol Surg 2019 Jan 8;3(1):104-113. Epub 2018 Nov 8.

Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan.

Background: Several studies have reported that modified Collard anastomosis is useful for cervical anastomosis after esophagectomy for thoracic esophageal cancer. However, no large-scale study has confirmed the efficacy of the modified Collard anastomosis.

Methods: Between 2008 and 2016, 398 consecutive esophageal cancer patients who underwent esophagectomy and cervical anastomosis were enrolled in this study. Read More

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http://dx.doi.org/10.1002/ags3.12220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345657PMC
January 2019
3 Reads

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study).

Ann Gastroenterol Surg 2019 Jan 11;3(1):96-103. Epub 2018 Oct 11.

Department of Gastroenterological Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Aim: As a result of the difficulty in effective prevention of gastroesophageal reflux, no standard reconstruction procedure after proximal gastrectomy (PG) has yet been established. The double-flap technique (DFT), or Kamikawa procedure, is an antireflux reconstruction procedure in esophagogastrostomy. The efficacy of DFT has recently been reported in several studies. Read More

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http://dx.doi.org/10.1002/ags3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345660PMC
January 2019
4 Reads

"Real-time" risk models of postoperative morbidity and mortality for liver transplants.

Ann Gastroenterol Surg 2019 Jan 2;3(1):75-95. Epub 2018 Nov 2.

Japanese Society of Gastroenterological Surgery Tokyo Japan.

Aim: A comprehensive description of morbidity and mortality risk factors for post liver transplant has not been available to date. In this study, we established real-time risk models of postoperative morbidities and mortality in liver transplant recipients using two Japanese nationwide databases.

Methods: Data from two Japanese nationwide databases were combined and used for this study. Read More

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http://dx.doi.org/10.1002/ags3.12217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345648PMC
January 2019

Perioperative and prognostic implication of albumin-bilirubin-TNM score in Child-Pugh class A hepatocellular carcinoma.

Ann Gastroenterol Surg 2019 Jan 27;3(1):65-74. Epub 2018 Sep 27.

Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine Nagoya Japan.

Background And Aim: A reliable classification for predicting postoperative prognosis and perioperative risk of hepatocellular carcinoma (HCC) patients is required to make a precise decision for HCC treatment. In the present study, we assessed the perioperative and prognostic importance of indocyanine green (ICG) testing, tumor-node-metastasis (TNM) stage, albumin-bilirubin (ALBI) grade, and ALBI-TNM (ALBI-T) score using consecutive resected HCC cases.

Methods: Between 1998 and 2011, 273 consecutive patients who underwent primary and curative hepatectomy for HCC were identified. Read More

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http://doi.wiley.com/10.1002/ags3.12212
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http://dx.doi.org/10.1002/ags3.12212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345730PMC
January 2019
9 Reads

Clinical usefulness of a perioperative bacteriological culture to treat patients with postoperative pneumonia after esophagectomy.

Ann Gastroenterol Surg 2019 Jan 21;3(1):57-64. Epub 2018 Sep 21.

Department of Digestive Surgery Osaka International Cancer Institute Osaka Japan.

Aim: The aim of the present study was to examine the usefulness of a perioperative bacteriological culture in predicting the pathogenic bacteria responsible for postoperative pneumonia after esophagectomy.

Methods: This study included 293 consecutive esophageal cancer patients who underwent esophagectomy with gastric conduit reconstruction. We compared the pathological bacteria that were detected in bacteriological cultures of sputum, mouthwash and gastric fluid on the second postoperative day with the pathogenic bacteria responsible for postoperative pneumonia. Read More

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http://dx.doi.org/10.1002/ags3.12210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345656PMC
January 2019
1 Read

Multidisciplinary approach of liver metastases from colorectal cancer.

Ann Gastroenterol Surg 2019 Jan 14;3(1):50-56. Epub 2019 Jan 14.

AP-HP Paul Brousse Hospital, Hepato-Biliary Center Paris Sud University Inserm U 935 Villejuif France.

Colorectal cancer liver metastases (CRLM) represent most of the causes of death in patients with colorectal cancer. Surgical resection is the only treatment that can provide the possibility of prolonged survival, or even cure, for patients with CRLM. Over the last few decades, survival of these patients has improved dramatically thanks to more effective chemotherapy, extension of surgical indications, and development of new surgical procedures. Read More

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http://dx.doi.org/10.1002/ags3.12227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345652PMC
January 2019

Neoadjuvant and adjuvant therapy for gastrointestinal stromal tumors.

Ann Gastroenterol Surg 2019 Jan 27;3(1):43-49. Epub 2018 Sep 27.

Department of Gastroenterological Surgery Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.

Gastrointestinal stromal tumors (GIST) are rare and mesenchymal in origin with a yearly incidence of 10-15 cases per million people. If it is technically resectable, surgical resection is the mainstay of therapy regardless of tumor location,. Although complete (R0) resection can be achieved in up to 85% of patients with primary disease, approximately 50% of patients experience recurrence or metastases within 5 years of primary resection. Read More

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http://dx.doi.org/10.1002/ags3.12211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345649PMC
January 2019
1 Read

Current state and future evolution of pancreatic islet transplantation.

Ann Gastroenterol Surg 2019 Jan 8;3(1):34-42. Epub 2018 Oct 8.

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation Department of Surgery Graduate School of Medicine University of Kyoto Kyoto Japan.

Pancreatic islet transplantation provides an effective treatment option for patients with type 1 diabetes (T1D) with intractable impaired awareness of hypoglycemia and severe hypoglycemic events. Currently, the primary goal of islet transplantation should be excellent glycemic control without severe hypoglycemia, rather than insulin independence. Islet transplant recipients were less likely to achieve insulin independence, whereas solid pancreas transplant recipients substantially had greater procedure-related morbidity. Read More

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http://dx.doi.org/10.1002/ags3.12214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345654PMC
January 2019
6 Reads

Recent advances of neoadjuvant chemoradiotherapy in rectal cancer: Future treatment perspectives.

Ann Gastroenterol Surg 2019 Jan 24;3(1):24-33. Epub 2018 Oct 24.

Division of Gastrointestinal Surgery Department of Surgery Kobe University Graduate School of Medicine Kobe Japan.

Neoadjuvant chemoradiotherapy (nCRT) has been widely used as a multidisciplinary approach for stage II/III rectal cancer. However, its safety and efficacy are controversial because previous studies have shown conflicting outcomes. The present review aimed to elucidate the benefits and limitations of nCRT for patients with rectal cancer. Read More

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http://dx.doi.org/10.1002/ags3.12213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345659PMC
January 2019

Current status of laparoscopic total gastrectomy.

Ann Gastroenterol Surg 2019 Jan 17;3(1):14-23. Epub 2018 Sep 17.

First Department of Surgery Faculty of Medicine University of Yamanashi Chuo Yamanashi Japan.

In this article, the current state of laparoscopic total gastrectomy (LTG) was reviewed, focusing on lymph node dissection and reconstruction. Lymph node dissection in LTG is technically similar to that in laparoscopic distal gastrectomy for early gastric cancer; however, LTG for advanced gastric cancer requires extended lymph node dissections including splenic hilar lymph nodes. Although a recent randomized controlled trial clearly indicated no survival benefit in prophylactic splenectomy for lymph node dissection at the splenic hilum, some patients may receive prognostic benefit from adequate splenic hilar lymph node dissection. Read More

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http://dx.doi.org/10.1002/ags3.12208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345655PMC
January 2019

Sentinel node navigation surgery in esophageal cancer.

Ann Gastroenterol Surg 2019 Jan 5;3(1):7-13. Epub 2018 Sep 5.

Department of Surgery Keio University School of Medicine Tokyo Japan.

Over the last 20 years, the sentinel node (SN) concept has been widely applied to the surgical staging of both breast cancer and melanoma. However, the validity of this concept has been controversial for esophageal cancer, because SN mapping for esophageal cancer is not considered to be technically easy because of the complicated multidirectional lymphatic networks of the esophagus and mediastinum. Nevertheless, studies including meta-analyses indicated that SN mapping may be feasible in early esophageal cancer. Read More

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http://dx.doi.org/10.1002/ags3.12206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345658PMC
January 2019
2 Reads

Is sentinel node mapping useful for esophageal cancer surgery?

Authors:
Soji Ozawa

Ann Gastroenterol Surg 2019 Jan 15;3(1):5-6. Epub 2019 Jan 15.

Department of Gastroenterological Surgery Tokai University School of Medicine Kanagawa Japan.

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http://dx.doi.org/10.1002/ags3.12231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345653PMC
January 2019

A new window in gastroenterological surgery.

Authors:
Masaki Mori

Ann Gastroenterol Surg 2019 Jan 18;3(1). Epub 2019 Jan 18.

Department of Surgery and Sciences Kyusyu University Fukuoka Japan.

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http://dx.doi.org/10.1002/ags3.12228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345650PMC
January 2019

Cancer-associated thrombosis: Role of direct oral anticoagulants.

Ann Gastroenterol Surg 2018 Nov 5;2(6):463-464. Epub 2018 Sep 5.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Suita Japan.

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http://dx.doi.org/10.1002/ags3.12204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236109PMC
November 2018

Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice.

Ann Gastroenterol Surg 2018 Nov 10;2(6):451-462. Epub 2018 Sep 10.

Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan.

Aim: Immunotherapies blocking the CD47-SIRPα pathway by targeting CD47 enhance macrophage phagocytosis of neoplastic cells in mouse models. As SIRPα exhibits relatively restricted tissue expression, SIRPα antagonists may be better tolerated than agents targeting CD47, which is ubiquitously expressed in many tissues. Here, we investigated the therapeutic impact of monoclonal antibodies (mAbs) against CD47 and/or SIRPα on gastroenterological tumors in syngeneic immunocompetent mouse models. Read More

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http://dx.doi.org/10.1002/ags3.12205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236110PMC
November 2018
10 Reads

Dual-center randomized clinical trial exploring the optimal duration of antimicrobial prophylaxis in patients undergoing pancreaticoduodenectomy following biliary drainage.

Ann Gastroenterol Surg 2018 Nov 17;2(6):442-450. Epub 2018 Sep 17.

Department of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine Nagoya Japan.

Objectives: The aim of this dual-center randomized controlled trial was to determine the optimal duration of antimicrobial prophylaxis in patients treated with pancreaticoduodenectomy (PD) who underwent preoperative biliary drainage (PBD) but were without cholangitis.

Background: Some reports showed that PBD in patients undergoing pancreatectomy increased the rate of perioperative complications. However, no clinical trial has evaluated the optimal duration of antimicrobial prophylaxis with a focus on patients who underwent PD following PBD. Read More

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http://dx.doi.org/10.1002/ags3.12209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236101PMC
November 2018
14 Reads

Clinical significance of the globulin-to-albumin ratio for prediction of postoperative survival in patients with colorectal cancer.

Ann Gastroenterol Surg 2018 Nov 29;2(6):434-441. Epub 2018 Aug 29.

Second Department of Surgery Dokkyo Medical University Tochigi Japan.

Aim: A previous study has revealed that the albumin/globulin ratio (GAR) before treatment is a predictor of cancer-specific survival in patients with colorectal cancer (CRC). The aim of the present study was to investigate the clinical significance of GAR for prediction of postoperative survival in patients with CRC.

Methods: Nine hundred and forty-one patients who had undergone elective CRC surgery were enrolled. Read More

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http://dx.doi.org/10.1002/ags3.12201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236099PMC
November 2018

Long-term outcomes following restorative proctocolectomy ileal pouch-anal anastomosis in pediatric ulcerative colitis patients: Multicenter national study in Japan.

Ann Gastroenterol Surg 2018 Nov 27;2(6):428-433. Epub 2018 Jul 27.

Department of Internal Medicine Toho University Sakura Medical Center Sakura Chiba Japan.

Background: Few studies have investigated surgical outcomes following a colectomy in pediatric patients with ulcerative colitis (UC).

Purpose: This study aimed to determine long-term outcomes in a large cohort of pediatric patients who underwent proctocolectomy with ileal pouch-anal anastomosis (IPAA) for UC.

Methods: Pediatric patients (<17 years old) who underwent surgery at 12 different hospitals in Japan between May 1979 and March 2015 were included in this study. Read More

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http://dx.doi.org/10.1002/ags3.12198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236100PMC
November 2018
21 Reads

High-risk group of upper and middle mediastinal lymph node metastasis in patients with esophagogastric junction carcinoma.

Ann Gastroenterol Surg 2018 Nov 13;2(6):419-427. Epub 2018 Oct 13.

Department of Surgery Keio University School of Medicine Tokyo Japan.

Aim: The aim of the present study was to clarify esophagogastric junction (EGJ) carcinoma patients who are at high risk of upper and middle mediastinal lymph node (MLN) metastasis.

Methods: This was a retrospective study and included 110 consecutive patients with EGJ carcinoma who underwent R0/R1 resection at Keio University Hospital between January 2000 and December 2013.

Results: Of the 110 patients, 18 (16. Read More

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http://dx.doi.org/10.1002/ags3.12215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236104PMC
November 2018
1 Read

Surgery for Pancreatic Cancer after neoadjuvant treatment.

Authors:
Thilo Hackert

Ann Gastroenterol Surg 2018 Nov 10;2(6):413-418. Epub 2018 Sep 10.

Department of General, Visceral and Transplantation Surgery University of Heidelberg Heidelberg Germany.

Pancreatic ductal adenocarcinoma (PDAC) remains to be a therapeutic challenge as only 15%-20% of all patients present with resectable tumor stages by the time of diagnosis. In the remaining patients, either local tumor extension or systemic spread are obstacles for a surgical therapy as the only chance for long-term survival. With regard to local tumor extension, PDAC has been classified as resectable, borderline-resectable (BR) or locally advanced (LA). Read More

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http://dx.doi.org/10.1002/ags3.12203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236102PMC
November 2018
14 Reads

Robotic-assisted surgery for rectal cancer: Current state and future perspective.

Ann Gastroenterol Surg 2018 Nov 5;2(6):406-412. Epub 2018 Sep 5.

Division of Minimally Invasive Treatment Tokyo Medical and Dental University Graduate School of Medicine Tokyo Japan.

Interest in minimally invasive surgery has increased in recent decades. Robotic-assisted laparoscopic surgery (RALS) was introduced as the latest advance in minimally invasive surgery. RALS has the potential to provide better clinical outcomes in rectal cancer surgery, allowing for precise dissection in the narrow pelvic space. Read More

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http://dx.doi.org/10.1002/ags3.12202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236106PMC
November 2018
14 Reads

Recent updates in perioperative chemotherapy and recurrence pattern of gastric cancer.

Ann Gastroenterol Surg 2018 Nov 29;2(6):400-405. Epub 2018 Aug 29.

Division of Minimally Invasive Surgery Department of Surgery Kobe University Graduate School of Medicine Kobe Japan.

Gastrectomy with D2 lymph node dissection has become the global standard procedure for locally advanced gastric cancer to maximally reduce locoregional recurrence. In East Asia, based on the evidence of the ACTS-GC and the CLASSIC trials, postadjuvant chemotherapy with S-1 monotherapy or capecitabine and oxaliplatin after curative D2 gastrectomy is the current standard strategy. However, approximately 20% to 30% of patients still develop distant recurrence even after these postadjuvant chemotherapies, especially in those with pathological stage III disease. Read More

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http://dx.doi.org/10.1002/ags3.12199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236108PMC
November 2018
26 Reads

Surgery: To what extent can we operate?

Authors:
Yoshihiro Kakeji

Ann Gastroenterol Surg 2018 Nov 25;2(6):398-399. Epub 2018 Oct 25.

Division of Gastrointestinal Surgery Department of Surgery Kobe University Graduate School of Medicine Kobe Japan.

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http://dx.doi.org/10.1002/ags3.12219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236103PMC
November 2018

Is surgical treatment necessary for uncomplicated acute appendicitis?

Ann Gastroenterol Surg 2018 Sep 13;2(5):394. Epub 2018 Jul 13.

Department of Gastroenterological Surgery Higashiosaka City Medical Center Higashiosaka Japan.

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http://dx.doi.org/10.1002/ags3.12192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139711PMC
September 2018

Effect of bevacizumab plus XELOX (CapeOX) chemotherapy on liver natural killer cell activity in colorectal cancer with resectable liver metastasis.

Ann Gastroenterol Surg 2018 Sep 18;2(5):383-393. Epub 2018 Jul 18.

Department of Gastroenterological and Transplant Surgery Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan.

Aim: We investigated the chemotherapy effect of resectable colorectal cancer with liver metastasis (CRLM) on the function of intrahepatic immune cells.

Methods: We classified patients into adjuvant chemotherapy (bevacizumab+CapeOX) after hepatectomy group (group A) and neoadjuvant chemotherapy followed by hepatectomy group (group B), and collected peripheral blood mononuclear cells (PBMC) and liver mononuclear cells (LMNC) to ascertain phenotypic and functional differences.

Results: There were no significant differences in lymphocyte fractions of either PBMC or LMNC between groups, except for the significantly lower percentage of natural killer (NK) cells in LMNC in group B than in group A. Read More

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http://dx.doi.org/10.1002/ags3.12195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139723PMC
September 2018
4 Reads

Laparoscopic left hemihepatectomy is suitable as a first step in pure laparoscopic major hepatectomy.

Ann Gastroenterol Surg 2018 Sep 13;2(5):376-382. Epub 2018 Jul 13.

Department of Surgery Iwate Medical University School of Medicine Morioka City Iwate Japan.

Aim: As a procedure, major laparoscopic liver resection (LLR) remains in the exploration phase. Previous studies have assessed major LLR en bloc, including hepatectomies of varying complexities; however, the number of segments alone does not convey the complexity of a resection. This study aimed to assess operative outcomes of LLR procedures with more than one sectionectomy, and to identify the best procedure as a first step when learning to carry out major LLR in order to make LLR a safer, more widely used procedure. Read More

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http://dx.doi.org/10.1002/ags3.12193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139718PMC
September 2018

Preoperative globulin-to-albumin ratio predicts outcome after curative resection in patients with gastric cancer.

Ann Gastroenterol Surg 2018 Sep 31;2(5):367-375. Epub 2018 Aug 31.

Second Department of Surgery Dokkyo Medical University Tochigi Japan.

Aim: The globulin-to-albumin ratio (GAR) is useful for prognostication of patients with various cancers. However, the significance of GAR in gastric cancer (GC) remains unclear. Our purpose was to investigate the relationship between the GAR and outcome after curative resection in GC patients. Read More

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http://dx.doi.org/10.1002/ags3.12200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139717PMC
September 2018

Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma.

Ann Gastroenterol Surg 2018 Sep 26;2(5):359-366. Epub 2018 Jul 26.

Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan.

Recent advances in dimensional imaging, surgical technique, and perioperative patient care have resulted in increased rates of complete resection with histopathologically negative margins and improved surgical outcomes in patients with extrahepatic cholangiocarcinoma. However, achieving cancer-free resection margins at ductal stumps in surgery for this disease remains challenging because of longitudinal extension, which is one of the hallmarks of extrahepatic cholangiocarcinoma. When the ductal resection margins are shown to be positive on examination of frozen sections, discrimination between carcinoma in situ and invasive carcinoma is clinically important because residual carcinoma in situ may lead to late local recurrence whereas residual invasive carcinoma is associated with early local recurrence. Read More

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http://dx.doi.org/10.1002/ags3.12196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139714PMC
September 2018
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Mechanisms of sepsis-induced immunosuppression and immunological modification therapies for sepsis.

Ann Gastroenterol Surg 2018 Sep 24;2(5):351-358. Epub 2018 Jul 24.

Department of Surgery National Defense Medical College Saitama Japan.

Surgical injury can be a life-threatening complication, not only due to the injury itself, but also due to immune responses to the injury and subsequent development of infections, which readily result in sepsis. Sepsis remains the leading cause of death in most intensive care units. Unfavorable outcomes of several high-profile trials in the treatment of sepsis have led researchers to state that sepsis studies need a new direction. Read More

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http://dx.doi.org/10.1002/ags3.12194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139715PMC
September 2018
2 Reads

Lateral pelvic lymph node dissection and radiation treatment for rectal cancer: Mutually exclusive or mutually beneficial?

Ann Gastroenterol Surg 2018 Sep 16;2(5):348-350. Epub 2018 Aug 16.

Department of Surgical Oncology The University of Texas MD Anderson Cancer Center Houston Texas.

Lateral pelvic lymph nodes (LPLN) in mid-/low rectal cancer pose a theoretical and practical challenge for the clinician and the patient, with geographical differences in management based on historical competing priorities. Although there has been a tendency to think of neoadjuvant radiation versus intraoperative LPLN dissection as a binary choice, they should be more constructively seen as complementary options in the personalized management of patients with rectal cancer. Herein we propose one potential algorithm for using these treatment options in this way based on local preoperative staging and the current evidence available. Read More

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http://dx.doi.org/10.1002/ags3.12197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139719PMC
September 2018
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Surgery with curative intent for stage IV gastric cancer: Is it a reality of illusion?

Authors:
Yasuhiro Kodera

Ann Gastroenterol Surg 2018 Sep 10;2(5):339-347. Epub 2018 Jul 10.

Department of Gastroenterological Surgery Nagoya University Graduate School of Medicine Nagoya Aichi Japan.

Gastric cancer with metastases outside of the regional lymph nodes is deemed oncologically unresectable. Nevertheless, some metastatic lesions are technically resectable by applying established surgical techniques such as para-aortic lymphadenectomy and hepatectomy. At the time of compilation of the Japanese gastric cancer treatment guidelines version 4, systematic reviews were conducted to see whether it is feasible to make any recommendation to dissect both the primary and metastatic lesions with intent to cure, possibly as part of multimodality treatment. Read More

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http://dx.doi.org/10.1002/ags3.12191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139716PMC
September 2018
1 Read

Cancer evolution and heterogeneity.

Ann Gastroenterol Surg 2018 Sep 4;2(5):332-338. Epub 2018 Jul 4.

Laboratory of Sequence Analysis Human Genome Center Institute of Medical Science University of Tokyo Tokyo Japan.

Undoubtedly, intratumor heterogeneity (ITH) is one of the causes of the intractability of cancers. Recently, technological innovation in genomics has promoted studies on ITH in solid tumors and on the pattern and level of diversity, which varies among malignancies. We profiled the genome in multiple regions of nine colorectal cancer (CRC) cases. Read More

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http://dx.doi.org/10.1002/ags3.12182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139712PMC
September 2018

Management of lateral pelvic lymph node in the East: Time to learn from the Western viewpoints.

Authors:
Tsuyoshi Konishi

Ann Gastroenterol Surg 2018 Sep 17;2(5):330-331. Epub 2018 Sep 17.

Department of Gastroenterological Surgery Cancer Institute Hospital of the Japanese Foundation for Cancer Research Tokyo Japan.

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http://dx.doi.org/10.1002/ags3.12207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139705PMC
September 2018

Obesity and recurrence-free survival in patients with hepatocellular carcinoma after achieving sustained virological response to interferon therapy for chronic hepatitis C.

Ann Gastroenterol Surg 2018 Jul 22;2(4):319-326. Epub 2018 Jun 22.

Department of Hepato-Biliary-Pancreatic Surgery Osaka City University Graduate School of Medicine Osaka Japan.

Aim: Some patients who achieve a sustained virological response (SVR) to interferon (IFN) treatment for chronic hepatitis C prior to hepatic resection for hepatocellular carcinoma (HCC) experience postoperative recurrence. This study investigated the relationship between obesity and postoperative HCC recurrence in SVR patients.

Methods: Fifty-nine patients who had achieved SVR before hepatic resection were evaluated. Read More

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http://dx.doi.org/10.1002/ags3.12183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036378PMC
July 2018
6 Reads

Is high serum programmed death ligand 1 level a risk factor for poor survival in patients with gastric cancer?

Ann Gastroenterol Surg 2018 Jul 5;2(4):313-318. Epub 2018 Jun 5.

Department of Surgery Toho University School of Medicine Tokyo Japan.

Background And Aim: Although the clinicopathological significance of the expression of programmed death ligand 1(PD-L1) in various cancer tissues has been reported, serum PD-L1 level has not been evaluated in patients with surgically treated gastric cancer. Therefore, we evaluated the clinicopathological characteristics and prognostic significance of preoperative serum PD-L1 levels in patients with gastric cancer.

Patients And Methods: Serum samples were obtained before surgery from 152 patients with gastric cancer, including 75 patients with stage I, 31 with stage II, 23 with stage III, and 23 with stage IV gastric cancer. Read More

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http://dx.doi.org/10.1002/ags3.12175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036390PMC
July 2018
5 Reads

Surgical management of hilar cholangiocarcinoma at Memorial Sloan Kettering Cancer Center.

Ann Gastroenterol Surg 2018 Jul 29;2(4):304-312. Epub 2018 Jun 29.

Department of Surgery Memorial Sloan Kettering Cancer Center New York NY USA.

Hilar cholangiocarcinoma, which represents approximately 60% of biliary tract malignancies, is increasing in incidence and presents an ongoing challenge for patients and hepatobiliary surgeons. Although the majority of patients present with advanced disease, the remaining minority of patients are best treated with surgical resection or transplant. Transplant is typically reserved for locally unresectable tumors often in the setting of underlying hepatic dysfunction and will not be discussed herein. Read More

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http://doi.wiley.com/10.1002/ags3.12181
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http://dx.doi.org/10.1002/ags3.12181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036362PMC
July 2018
1 Read

Current status of immunotherapy against gastrointestinal cancers and its biomarkers: Perspective for precision immunotherapy.

Ann Gastroenterol Surg 2018 Jul 22;2(4):289-303. Epub 2018 Jun 22.

Department of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Ube Japan.

Immunotherapy has shown encouraging results for some types of tumor. Although enormous efforts have been made toward the development of specific immunotherapeutic strategies against gastrointestinal cancers, such as adoptive T-cell transfer, peptide vaccines, or dendritic cell vaccines, the efficacy of immunotherapies prior to the introduction of immune checkpoint inhibitors was not substantial. This article reviews immunotherapy for gastrointestinal malignancies, including cell therapy, peptide vaccine, and immune checkpoint inhibitors, and attempts to resolve the immunosuppressive conditions surrounding the tumor microenvironment, and to construct novel combination immunotherapies beyond immune checkpoint inhibitors. Read More

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http://dx.doi.org/10.1002/ags3.12180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036392PMC
July 2018
6 Reads