1,614 results match your criteria Annals of diagnostic pathology[Journal]


PD-L1 expression by immunohistochemistry in salivary duct carcinoma.

Ann Diagn Pathol 2019 Apr 3;40:49-52. Epub 2019 Apr 3.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Immune checkpoint inhibitors play an increasing role in oncologic care. PD-L1 expression is associated with survival and predicts response to PD-1 or PD-L1 inhibitors in a variety of tumors. Our aim is to evaluate the frequency and prognostic significance of PD-L1 expression in salivary duct carcinoma. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.04.001DOI Listing

Ring sideroblasts in chronic phase of polycythemia vera identifies a subset of patients with an increased risk of progression to blast phase.

Ann Diagn Pathol 2019 Mar 19;40:45-48. Epub 2019 Mar 19.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Blast phase of PV is often associated with a complex karyotype (CK) and bilineage dysplasia. We hypothesized that BM morphologic abnormalities detected in the Chronic phase (CP) can identify patients with an increased risk of developing blast phase (BP). We also compared cases of BP PV to a group of acute myeloid leukemia cases with JAK2 mutation (AML-JAK2mut). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.03.001DOI Listing
March 2019
3 Reads

Clinicopathological features of duodenal bulb biopsies and their relationship with upper gastrointestinal diseases.

Ann Diagn Pathol 2019 Feb 10;40:40-44. Epub 2019 Feb 10.

Department of Gastroenterology, Peking University Third Hospital, 49 Rd. Garden, Haidian District, Beijing, PR China.

Aim: To assess the prevalence of the lesions in duodenal bulb mucosa and the relationship between duodenal lesions and upper gastrointestinal diseases, including helicobacter pylori infection.

Methods: Clinical, endoscopic and pathological data of the cases with duodenal bulb and gastric mucosal biopsy from January 2005 to May 2017 were analyzed retrospectively.

Results: A total of 3540 patients were enrolled. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.006DOI Listing
February 2019
2 Reads

High-grade ovarian serous carcinomas: Significant correlation of histologic patterns with IMP3 and E-Cadherin predicting disease recurrence and survival.

Ann Diagn Pathol 2019 Feb 28;40:30-39. Epub 2019 Feb 28.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address:

Most high-grade serous carcinomas (HGSC) of the ovary are advanced stage tumors with early recurrences. However, some tumors do not recur and have a better survival. We identified such cases of HGSC and compared those with the cases that recurred and assessed the relationship between patterns of invasion (intracystic, IC; micropapillary, MP; nonpapillary, NP) with IMP3 and E-Cadherin expression, and evaluated their predictive role in recurrence and survival. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.013DOI Listing
February 2019
1 Read

Clear cell carcinoma of testis: A review.

Ann Diagn Pathol 2019 Mar 20;40:26-29. Epub 2019 Mar 20.

Department of Pathology and Genomic Medicine, Weill Medical College of Cornell University, Houston, TX, United States of America. Electronic address:

Clear cell Mullerian-type adenocarcinoma of the testis is an exceedingly rare entity, and its histogenesis and clinical behavior are still poorly understood. We discuss three cases of clear cell carcinoma of the testis, compiled from a review of the literature and our personal experience. Microscopically, the tumors closely resembled clear cell carcinoma of the ovary, displaying papillae lined by clear cells with areas of hobnailing. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.03.002DOI Listing

Characterization of applicants for residency training in pathology: Does diversity exist?

Ann Diagn Pathol 2019 Feb 10;40:23-25. Epub 2019 Feb 10.

Harvard Medical School, Boston, MA, USA; Pathology Service, Massachusetts General Hospital, Boston, MA, USA.

Context: A diverse workforce has been shown to improve productivity and innovation. The level of diversity among pathology residency applicants has not previously been reported.

Objective: This study aims to characterize the applicants at an academic pathology department to gain a better understanding of diversity among them. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.010DOI Listing
February 2019

DOG1 immunohistochemical staining of testicular biopsies is a reliable tool for objective assessment of infertility.

Ann Diagn Pathol 2019 Feb 20;40:18-22. Epub 2019 Feb 20.

Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Testicular biopsy may be a component of the work-up of male infertility. However, no reliable diagnostic tools are available for objective quantitative assessment of spermatogenic cells. It is well known that MAGE-A4 is selectively expressed in spermatogonia and our group has previously demonstrated that DOG1 differentially stains germ cells. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.015DOI Listing
February 2019

Hematolymphoid neoplasms are common in bone marrow biopsies performed for non-specific, diffuse marrow signal alterations on magnetic resonance imaging.

Ann Diagn Pathol 2019 Feb 15;40:7-12. Epub 2019 Feb 15.

Division of Hematopathology, University of Pittsburgh Medical Center, Hill Building, 3rd Floor, 3477 Euler Way, Pittsburgh, PA 15213, USA.

Aims: MRI is an imaging modality used for a wide range of clinical indications. Occasionally, non-specific, diffuse T1 marrow signal alterations are identified, which may prompt a bone marrow biopsy (BM). However, there is little data on the clinicopathologic significance of this signal alteration. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.002DOI Listing
February 2019
1 Read

Crystal storing histiocytosis: Unusual clinical presentations in two patients.

Ann Diagn Pathol 2019 Jan 17;40:13-17. Epub 2019 Jan 17.

Houston Methodist Hospital, 6565 Fannin St, M227, Houston, TX 77030, United States of America; Weill Medical College of Cornell University, New York, NY 10065, United States of America.

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http://dx.doi.org/10.1016/j.anndiagpath.2019.01.003DOI Listing
January 2019

Amyloid and hyaline globules in undifferentiated nasopharyngeal carcinoma.

Ann Diagn Pathol 2019 Feb 19;40:1-6. Epub 2019 Feb 19.

Department of Pathology, National University Health System, Singapore. Electronic address:

We characterize the clinicopathological features of two patients (one 38 year old woman and one 42 year old man, both of Chinese ethnicity) with Epstein Barr Virus positive non-keratinizing nasopharyngeal carcinoma from an endemic region with prominent presence of amyloid and one case with both amyloid and abundant intracytoplasmic hyaline globules. The amyloid material was positive for Congo red and showed apple green birefringence when examined under polarized light. The amyloid was immunoreactive for cytokeratins and was located both intra- and extracellularly. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.016DOI Listing
February 2019

Evaluation and reporting of biopsies from the columnar-lined esophagus and gastro-esophageal junction (GEJ).

Ann Diagn Pathol 2019 Feb 15;39:111-117. Epub 2019 Feb 15.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America.

This review is part of a collaboration between the American Registry of Pathology (the publisher of the Armed Forces Institute of Pathology Fascicles) and Annals of Diagnostic Pathology. It is in a series of expert recommendations on topics encountered in daily practice. The authors, two pathologists and a gastroenterologist, met on 19 January 2019 tasked with developing expert recommendations on reporting biopsies from the columnar lined esophagus and gastroesophageal junction. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.012DOI Listing
February 2019

American Registry of Pathology Expert Opinions: Immunohistochemical evaluation of classic Hodgkin lymphoma.

Ann Diagn Pathol 2019 Feb 6;39:105-110. Epub 2019 Feb 6.

Mayo Clinic, Rochester, MN, United States of America.

The diagnosis of classic Hodgkin lymphoma requires immunohistochemical confirmation in most cases and one can argue for these studies as standard-of-care in the diagnostic workup. The authors propose a panel of studies for primary identification of CHL to include: CD3, CD20, CD15, CD30 and PAX5. When pattern discordances are identified, additional assessment is recommended. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.001DOI Listing
February 2019
1 Read

A potpourri of pathogenetic pathways in endometrial carcinoma with a focus on Lynch Syndrome.

Ann Diagn Pathol 2019 Feb 16;39:92-104. Epub 2019 Feb 16.

University of the Witwatersrand, Ampath National Laboratories, South Africa. Electronic address:

Endometrial carcinoma is the most frequently occurring female genital tract malignancy in developed nations, with a rising annual incidence. Endometrioid endometrial carcinoma (EEC), the most common histological variant, differs in morphologic and molecular characteristics from serous carcinomas but morphological distinction of high-grade EECs from serous carcinomas may prove difficult. Thus, molecular categorization of tumors may allow for better tumor classification with greater insight into the underlying biology of endometrial carcinomas with new therapeutic options. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.003DOI Listing
February 2019
1 Read

Utilization of spectrins βI and βIII in diagnosis of hepatocellular carcinoma.

Ann Diagn Pathol 2019 Feb 15;39:86-91. Epub 2019 Feb 15.

Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, United States of America. Electronic address:

Spectrins are a group of cytoskeletal proteins which participate in many important cellular functions. It has been suggested that loss of spectrin isoforms may be associated with tumorigenesis of lymphoma, leukemia, gastric cancer and hepatocellular carcinoma (HCC). We recently reported that βI spectrin expression was present in normal hepatocytes but lost in HCC cells, which suggested that spectrins may be helpful markers in diagnosis of HCC. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.009DOI Listing
February 2019
3 Reads

Cystic and pseudocystic pulmonary malformations in children: Clinico-pathological correlation.

Ann Diagn Pathol 2019 Feb 16;39:78-85. Epub 2019 Feb 16.

Unidad de Investigación Médica en Enfermedades Respiratorias, Unidad Médica de Alta Especialidad, Hospital de Pediatría Silvestre Frenk Freund, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.

Pulmonary malformations are rare disorders, with cystic and pseudocystic pulmonary malformations (CPPM) the most frequent, and constitute the first cause of lobectomy in children <1 year of age. Morphological overlap of congenital cystic pulmonary lesions might correspond to a spectrum of lesions in which bronchial atresia is a common etiopathogenetic mechanism. We aimed to report the frequency of CPPM resected in a tertiary-level hospital and to evaluate the degree of agreement between presurgical and anatomopathological diagnoses. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.005DOI Listing
February 2019
2 Reads

Revisiting localized malignant mesothelioma.

Ann Diagn Pathol 2019 Feb 19;39:74-77. Epub 2019 Feb 19.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Malignant Mesothelioma is an uncommon tumor that usually presents with diffuse pleural involvement and carries a dismal prognosis. Rarely, however, it can present as a localized, circumscribed mass or focal pleural lesion without evidence of diffuse spread. We found four such cases in our database. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.014DOI Listing
February 2019
1 Read

Sensitivity and specificity of fine needle aspiration for the diagnosis of mediastinal lesions.

Ann Diagn Pathol 2019 Feb 10;39:69-73. Epub 2019 Feb 10.

Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. Electronic address:

Fine needle aspiration cytology (FNAC) of mediastinal masses allows for rapid on-site evaluation and the triaging of material for ancillary studies. However, surgical pathology is often considered to be the gold standard for diagnosis. This study examines the sensitivity and specificity of FNAC compared to a concurrent or subsequent surgical pathology specimen in 77 mediastinal lesions. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.011DOI Listing
February 2019
2 Reads

Fumarate hydratase deficient renal cell carcinoma: Chromosomal numerical aberration analysis of 12 cases.

Ann Diagn Pathol 2019 Feb 10;39:63-68. Epub 2019 Feb 10.

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzeň, University Hospital Plzen, Pilsen, Czech Republic. Electronic address:

Hereditary leiomyomatosis and renal cell carcinoma-associated renal cell carcinoma (HLRCC)/fumarate hydratase deficient renal cell carcinoma (FHRCC) is defined by molecular genetic changes (mutation/LOH in fumarate hydratase (FH) gene). We investigated chromosomal numerical aberration pattern (CNV) in FHRCC/HLRCC using array comparative genomic hybridization analysis and low pass whole genome sequencing. Genetic analysis was successfully completed in 12 tumors. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.008DOI Listing
February 2019
3 Reads
1.112 Impact Factor

Prostatic ductal adenocarcinoma with cribriform architecture has worse prognostic features than non-cribriform-type.

Ann Diagn Pathol 2019 Feb 10;39:59-62. Epub 2019 Feb 10.

Department of Pathology and Laboratory Medicine, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

Prostatic ductal adenocarcinoma (PDA) is a rare histologic subtype of prostate cancer characterized by large glands lined with tall columnar pseudostratified epithelium. PDA has several architectural patterns, with papillary and cribriform being the most common. The cribriform pattern of acinar carcinoma has shown to be associated with a worse prognosis in terms of disease progression and disease-specific mortality. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.007DOI Listing
February 2019

The frequency of NOTCH1 variants in T-acute lymphoblastic leukemia/lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma among Jordanian patients.

Ann Diagn Pathol 2019 Jan 24;39:53-58. Epub 2019 Jan 24.

Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, Amman, Jordan. Electronic address:

The transmembrane receptor NOTCH1 is thought to be associated with the development and progression of T-acute lymphoblastic leukemia (T-ALL)/T-lymphoblastic lymphoma (T-LBL) and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The current study aimed to characterize NOTCH1 expression and elucidate the variants in the functional PEST domain of the receptor in T-ALL/LBL and CLL/SLL. The nuclear expression of NOTCH1 protein was detected in 25% and 5% of cases of T-ALL/LBL and CLL/SLL, respectively, whereas cytoplasmic expression was detected in 33. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.01.004DOI Listing
January 2019
1 Read
1.112 Impact Factor

Fatty acid synthase, Her2/neu, and E2F1 as prognostic markers of progression in non-muscle invasive bladder cancer.

Ann Diagn Pathol 2019 Jan 17;39:42-52. Epub 2019 Jan 17.

Surgical Oncology Department, Al-Ahrar Zagazig Teaching Hospital, Egypt.

Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease which has an unpredictable risk of progression to muscle-invasive bladder cancer (MIBC). The selection of patients who may benefit from early radical intervention is a challenge. To define the useful prognostic markers for progression, we analyzed the immunohistochemical expression of fatty acid synthase (FASN), Her2/neu, and E2F1 in 60 cases of NMIBC who underwent TURBT and adjuvant intravesical bacillus-Calmette-Guérin (BCG). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.01.002DOI Listing
January 2019
2 Reads
1.112 Impact Factor

Dedifferentiated gastrointestinal stromal tumor: Recent advances.

Ann Diagn Pathol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital and Weill Medical College of Cornell University, Houston, TX 77030, USA. Electronic address:

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal lesions of the gastrointestinal tract. A small minority of GISTs exhibit morphologic and phenotypic changes and differentiate into an unusual phenotype through the process of dedifferentiation. Dedifferentiation can occur either de novo or after prolonged treatment with imatinib, a selective tyrosine kinase inhibitor. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.005DOI Listing
December 2018
5 Reads

Undifferentiated endometrial carcinoma: A selected immunohistochemical panel including PAX-8 and E-cadherin for aiding distinction from other endometrial carcinomas.

Ann Diagn Pathol 2019 Jan 10;39:36-41. Epub 2019 Jan 10.

Department of Surgical Pathology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, PR China.

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http://dx.doi.org/10.1016/j.anndiagpath.2019.01.001DOI Listing
January 2019
1 Read

Mutation profiling in the PIK3CA, TP53, and CDKN2A genes in circulating free DNA and impalpable breast lesions.

Ann Diagn Pathol 2019 Jan 3;39:30-35. Epub 2019 Jan 3.

Circulating Biomarkers Laboratory, Faculty of Medical Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-170, Brazil; Graduate Program in Medical Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-170, Brazil. Electronic address:

Breast impalpable lesions have become a clinical dilemma because they are small, presenting a heterogeneous cellular phenotype. The aim of this study was to evaluate the mutational profile of the PIK3CA, TP53, and CDKN2A genes, comparing the mammary tissue with the respective circulating free DNA (cfDNA). The PIK3CA, TP53, and CDKN2A genes were sequenced (PCR-Sanger) in 58 women with impalpable lesions (49 malignant and 9 benign) with the respective cfDNA. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.008DOI Listing
January 2019
18 Reads

Retroperitoneal low grade endometrial stromal sarcoma with florid endometrioid glandular differentiation: Cytologic-histologic correlation and differential diagnosis.

Ann Diagn Pathol 2018 Dec 28;39:25-29. Epub 2018 Dec 28.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

Low grade endometrial stromal sarcoma (LGESS) is a rare neoplasm that typically arises in the uterine corpus and accounts for less than 1% of uterine sarcomas. Infrequently, extra-uterine LGESS can occur. Histologically, LGESS is characterized by a monotonous population of cells that resemble the proliferative phase of endometrial stroma and in their classic form they exhibit tongue-like growth pattern of infiltration and/or lymphovascular invasion. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.006DOI Listing
December 2018
1 Read

Processing the entire capsule in thyroid follicular lesions improves diagnostic accuracy.

Ann Diagn Pathol 2018 Dec 23;39:21-24. Epub 2018 Dec 23.

St. John Hospital and Medical Center, Detroit, MI, USA.

Background: There is contradictory evidence in literature with respect to diagnosis and management of follicular lesions of the thyroid gland. From surgical pathology stand point, pathologists require submission and processing of entire capsule for microscopic evaluation. This can be extremely challenging especially in larger lesions. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.007DOI Listing
December 2018
3 Reads

Fine needle aspiration of non-thyroidal head and neck masses: Correlation of the cyto-histopathological diagnoses, causes of inconsistency and traps.

Ann Diagn Pathol 2018 Dec 18;39:15-20. Epub 2018 Dec 18.

Department of Pathology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.004DOI Listing
December 2018
3 Reads

Diagnostic and reporting issues of preneoplastic polyps of the large intestine with early carcinoma.

Authors:
Dale C Snover

Ann Diagn Pathol 2018 Dec 22;39:1-14. Epub 2018 Dec 22.

The University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 240 Delaware St SE, Minneapolis, MN 55455, USA. Electronic address:

Premalignant polyps of the large intestine are common specimens in surgical pathology. They consist of several different subtypes identifiable by histological criteria that are associated with different molecular characteristics and with the development of different types of colorectal carcinoma. The most common of these is the conventional adenoma, which most commonly leads to carcinomas with a low degree of methylation (CIMP-L) that are microsatellite stable. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.001DOI Listing
December 2018
2 Reads

Aberration of Nrf2‑Bach1 pathway in colorectal carcinoma; role in carcinogenesis and tumor progression.

Ann Diagn Pathol 2019 Feb 22;38:138-144. Epub 2018 Nov 22.

Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Nrf2 and Bach1 are important transcriptional factors that protect against reactive oxygen species (ROS). Although aberration of these molecules was associated with malignant transformation and progression, their aberration pattern in colorectal carcinoma (CRC) is not yet fully studied. In this study, Nrf2 and Bach1 were immunohistochemically examined in 93 formalin-fixed paraffin-embedded blocks of colonic tumors (65 carcinoma with their corresponding surgical margins and 28 adenomas). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.003DOI Listing
February 2019
3 Reads

Update on the pathology of liver neoplasms.

Ann Diagn Pathol 2019 Feb 12;38:126-137. Epub 2018 Oct 12.

Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, United States of America; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America. Electronic address:

Many advances have developed in the pathology of liver tumors in the recent decade. Examples of these advances include the use of glutamine synthetase in the diagnosis of focal nodular hyperplasia, subtyping of hepatocellular adenomas using molecular and immunohistochemical methods, the unraveling of the fusion transcript between the DNAJB1 gene and the PRKACA gene in fibrolamellar carcinoma, and the more unified classification and terminology in intrahepatic bile duct tumors and their precursor lesions. Nevertheless, challenges still remain, e. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.005DOI Listing
February 2019
6 Reads

Sclerosing Kaposi's sarcoma of the adrenal gland in an HIV-infected patient under antiretroviral therapy.

Ann Diagn Pathol 2019 Feb 14;38:123-125. Epub 2018 Dec 14.

Department of Pathology, Hospital Clínic de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.003DOI Listing
February 2019
1 Read

The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of the uterine cervix.

Ann Diagn Pathol 2019 Feb 14;38:115-122. Epub 2018 Dec 14.

The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; Phylogeny Inc, Powell, OH, USA. Electronic address:

Importin-β, exportin-5, p16, Ki-67, Mcl1, PDL1, and cFLIP are each over-expressed in the majority of CIN 1 lesions. These biomarkers, plus HPV E6/E7 RNA, were analyzed in carcinoma-in-situ (CIS), microinvasive, and squamous cell carcinoma (SCC) of the uterine cervix and cervical carcinoma cell lines. Only p16 and Ki-67 continued to be over-expressed in CIS, with a concomitant marked increase in E6/E7 RNA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183038
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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.001DOI Listing
February 2019
12 Reads

Hit or a miss: Concordance between histopathologic-endoscopic findings in gastric mucosal biopsies.

Ann Diagn Pathol 2019 Feb 14;38:106-114. Epub 2018 Dec 14.

Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, United States of America. Electronic address:

Background: Current literature shows a variable degree of concordance between endoscopic and histopathologic findings in gastric mucosal biopsies. Most prior studies have focused on specific gastric entities such as gastritis in patients with high prevalence of Helicobacter pylori (H. pylori). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183032
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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.002DOI Listing
February 2019
19 Reads

Post-thymic CD4 positive cytotoxic T cell infiltrates of the skin: A clinical and histomorphologic spectrum of the unique CD4 positive T cell of immunosenescence.

Ann Diagn Pathol 2019 Feb 27;38:99-105. Epub 2018 Oct 27.

Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

T cell lymphoproliferative disorders that arise in the skin are mainly derived from post thymic T cells most commonly of CD4 subset. Human CD4 positive T cells are dynamic exhibiting phenotypic and functional malleability. For example, with repetitive antigen exposure most commonly associated with age, CD4 positive T cells acquire a cytotoxic phenotype. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183031
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.010DOI Listing
February 2019
7 Reads

Measured residual tumor cellularity correlates with survival in neoadjuvant treated pancreatic ductal adenocarcinomas.

Ann Diagn Pathol 2019 Feb 5;38:93-98. Epub 2018 Nov 5.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.013DOI Listing
February 2019
12 Reads

Clinicopathological study of role of CD34 expressions in the stroma of premalignant and malignant lesions of uterine cervix.

Ann Diagn Pathol 2019 Feb 29;38:87-92. Epub 2018 Nov 29.

Department of Pathology, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh, India.

CD34 is a transmembrane glycoprotein that is thought to be involved in the modulation of cell adhesion and signal transduction. The connective tissue stroma of virtually all human organs contain large amounts of resident CD34+ fibrocytes, which are involved in multiple functions such as wound healing, secretion of cytokines and also participate in stromal remodeling. It has been seen in various studies that absence of CD34+ fibrocytes within the stroma is associated with invasive carcinomas. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.007DOI Listing
February 2019
16 Reads

Papillary pattern in clear cell renal cell carcinoma: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 23 cases.

Ann Diagn Pathol 2019 Feb 22;38:80-86. Epub 2018 Nov 22.

Department of Pathology, Charles University, Faculty of Medicine in Plzeň, Pilsen, Czech Republic. Electronic address:

Clear cell renal cell carcinoma (ccRCC), the most common histologic subtype of RCCs, demonstrates a wide spectrum of morphologic features (i.e., low-grade spindle cell, syncytial giant cells, and mucin-producing cells). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.004DOI Listing
February 2019
9 Reads
1.112 Impact Factor

Carcinoid tumors of the thymus and Cushing's syndrome: Clinicopathologic features and current best evidence regarding the cell of origin of these unusual neoplasms.

Ann Diagn Pathol 2019 Feb 22;38:71-79. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.006DOI Listing
February 2019
4 Reads

FOXP3 and CD25 double staining antibody cocktails identify regulatory T cells in different types of tumor tissues using tissue microarrays.

Ann Diagn Pathol 2019 Feb 22;38:67-70. Epub 2018 Nov 22.

Department of Pathology, University of Texas McGovern Medical School, Houston, TX, 77030, United States of America. Electronic address:

Regulatory T cells (Tregs) are CD4+ T cells that express CD25 and transcription factor Forkhead box P3 (FOXP3), and Tregs play a central role in regulation of tumor immunity. FOXP3 immunohistochemistry has been widely used to study Tregs in paraffin embedded tissue, and flow cytometry using fresh tissue has been used to identify FOXP3+/CD25+ double positive Tregs. In our study, we validated the FOXP3/CD25 double staining antibody cocktails for detecting Tregs in paraffin-embedded tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183034
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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.005DOI Listing
February 2019
13 Reads

Levels of CD8+ tumor infiltrating lymphocytes correlate with disease burden in bone marrow of therapy Naïve multiple myeloma patients.

Ann Diagn Pathol 2018 Nov 28. Epub 2018 Nov 28.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.008DOI Listing
November 2018
13 Reads

Somatostatin receptor SSTR2A and SSTR5 expression in neuroendocrine breast cancer.

Ann Diagn Pathol 2019 Feb 20;38:62-66. Epub 2018 Nov 20.

"Ljudevit Jurak" Department of Pathology and Cytology, Clinical Hospital Center "Sestre milosrdnice", Vinogradska cesta 29, 10000 Zagreb, Croatia. Electronic address:

Neuroendocrine breast cancer (NEBC) is a group of rare tumors, which could benefit from therapy targeting the somatostatin receptors (SSTRs). In particular, SSTR2A and SSTR5 are potential targets given their consistent expression in gastrointestinal and pancreatic primary and metastatic neuroendocrine cancers. Currently, there are no studies describing the expression of SSTRs in NEBC. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.002DOI Listing
February 2019
19 Reads
1.112 Impact Factor

Gene and protein expression of E-cadherin and NCAM markers in non-functioning pituitary adenomas.

Ann Diagn Pathol 2019 Feb 9;38:59-61. Epub 2018 Oct 9.

Postgraduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), R. Sarmento Leite, 245 - Centro Histórico, 90050-170 Porto Alegre, RS, Brazil; Neuroendocrinology Center, Complexo Hospitalar Santa Casa, Av. Independência, 75 - Independência, Porto Alegre - RS, 90035-072 Porto Alegre, RS, Brazil.

Non-functioning pituitary adenomas (NFPA) are classified as benign tumors of slow growth, but 40% of them present local invasion, a characteristic of behavior still unpredictable with the use of current tumor markers. This work aims to evaluate the tissue markers E-cadherin and NCAM, which act on cell adhesion, in tumor tissue samples of NFPA and its relationship with the degree of local invasiveness. Gene expression of E-cadherin (CDH1) and NCAM (NCAM1) was assessed by real-time PCR and tissue expression by immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.003DOI Listing
February 2019
4 Reads

Thyroid tumors with follicular architecture.

Ann Diagn Pathol 2019 Feb 18;38:51-58. Epub 2018 Oct 18.

Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL, United States of America. Electronic address:

Thyroid tumors with follicular architecture encompass a considerable array of distinct entities. These lesions share significant morphologic overlap, but portend different prognostic and therapeutic implications. Due to their similar growth patterns, distinction between these tumors can be difficult; remarkable interobserver variability exists, even between expert endocrine pathologists. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.007DOI Listing
February 2019
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Well-differentiated papillary mesothelioma: A 17-year single institution experience with a series of 75 cases.

Ann Diagn Pathol 2019 Feb 28;38:43-50. Epub 2018 Oct 28.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

We present our experience with 75 cases of well-differentiated papillary mesothelioma (WDPM) that were diagnosed at our institution between 2000 and 2017. The patients included 58 females and 17 males with age ranging from 18 to 69 years (mean, 42 years). Clinically, the vast majority of WDPMs were incidental findings during laparotomy or laparoscopic surgery for a variety of benign or malignant disease. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.012DOI Listing
February 2019
19 Reads

Virus-associated carcinomas of the head & neck: Update from the 2017 WHO classification.

Ann Diagn Pathol 2019 Feb 22;38:29-42. Epub 2018 Oct 22.

Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.

Virus-associated carcinomas of the head and neck represent an unusual confluence of infections spread by viral transmission and cellular dysregulation resulting in carcinogenesis. While much remains to be elucidated about the exact progression from infection to cancer, a basic framework of viral biology can complement the pathologist's understanding of morphology. This context informs the pathologist's everyday practice, including selecting ancillary studies, communicating prognostically relevant findings, and participating in treatment planning. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.008DOI Listing
February 2019
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The impact of reporting tumor size in breast core needle biopsies on tumor stage: A retrospective review of five years of experience at a single institution.

Ann Diagn Pathol 2019 Feb 13;38:26-28. Epub 2018 Oct 13.

A.M. Rywlin, MD Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL, United States of America; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.

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February 2019
6 Reads

Localization of TNF alpha in ileocolonic biopsies of patients with inflammatory bowel disease.

Ann Diagn Pathol 2019 Feb 27;38:20-25. Epub 2018 Oct 27.

Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia School of Medicine, Perugia, Italy.

Background: Although antitumor necrosis factor alfa (TNFα) agents are widely used to treat patients with inflammatory bowel diseases (IBD) - both Crohn's disease (CD) and ulcerative colitis (UC) - there is still some uncertainty in the cell type expressing TNFα in human ileo-colonic segments.

Aims: We investigated the immunohistochemical (IHC) expression of TNFα in the ileo-colonic segments of patients with both active CD and UC, to establish its anatomic and cellular localization in the inflamed sites. Our aim was to identify patients potentially resistant to anti TNFα agents. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.011DOI Listing
February 2019
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Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues.

Ann Diagn Pathol 2019 Feb 2;38:6-10. Epub 2018 Oct 2.

Neogenomics, Aliso Viejo, CA, United States of America; M.D. Anderson Cancer Center, University of Texas, Department of Hematopathology, Houston, TX, United States of America. Electronic address:

The recent 2017 update of the World Health Organization classification of lymphomas has significant changes from the previous edition. Subtypes of large B cell lymphoma and related aggressive B cell lymphomas are addressed. Clinicopathological features of entities as related to morphology, immunophenotype, cell of origin, and molecular/genetic findings are reviewed with emphasis on changes or updates in findings. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.014DOI Listing
February 2019
16 Reads

Mimickers of urothelial neoplasia.

Ann Diagn Pathol 2019 Feb 26;38:11-19. Epub 2018 Sep 26.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address:

Management of malignant urothelial tumors is often associated with extended costly treatments, some with significant morbidity. Advanced tumors are treated with radical cystectomy with neoadjuvant or adjuvant radiation or chemotherapy. Over and under interpretation of histological findings from biopsies and transurethral resections of urothelial lesions may either incur treatments with significant side effects or miss a possible window of cure, respectively. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.012DOI Listing
February 2019
7 Reads

FTO mRNA expression in the lower quartile is associated with bad prognosis in clear cell renal cell carcinoma based on TCGA data mining.

Ann Diagn Pathol 2019 Feb 25;38:1-5. Epub 2018 Oct 25.

Department of Urology, The Second Hospital of Dalian Medical University, Dalian, China. Electronic address:

Fat mass and obesity associated (FTO) is a protein-coding gene, also known as the obesity gene. It has been reported previously to be associated with a variety of malignant cancers, such as breast, thyroid and acute myeloid leukemia. The aim of the present study was to investigate the FTO mRNA expression in human clear cell renal cell carcinoma and its clinical value. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.009DOI Listing
February 2019
2 Reads