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    4607 results match your criteria Annals of clinical biochemistry[Journal]

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    ANNALS EXPRESS: Validation of an automated UPLC IgG N-glycan analytical method applicable to Classical Galactosaemia.
    Ann Clin Biochem 2018 Jan 1:4563218762957. Epub 2018 Jan 1.
    Salford Royal NHS Foundation Trust.
    Background: Classical galactosaemia (OMIM 230400) is a rare disorder of carbohydrate metabolism caused by deficiency of the galactose-1-phosphate uridyltransferase enzyme. The pathophysiology of the long-term complications, mainly cognitive, neurological and female fertility problems, remains poorly understood. Current clinical methods of biochemical monitoring lack precision and individualisation with an identified need for improved biomarkers for this condition. Read More

    Improved technical success and radiation safety of adrenal vein sampling using rapid, semi-quantitative point-of-care cortisol measurement.
    Ann Clin Biochem 2018 Jan 1:4563218760352. Epub 2018 Jan 1.
    1 Department of Clinical Biochemistry, PathWest 418838 Fiona Stanley Hospital Network, Murdoch, Western Australia, Australia.
    Objective Primary aldosteronism is a curable cause of hypertension which can be treated surgically or medically depending on the findings of adrenal vein sampling studies. Adrenal vein sampling studies are technically demanding with a high failure rate in many centres. The use of intraprocedural cortisol measurement could improve the success rates of adrenal vein sampling but may be impracticable due to cost and effects on procedural duration. Read More

    Post hoc analysis of plasma amino acid profiles: towards a specific pattern in autism spectrum disorder and intellectual disability.
    Ann Clin Biochem 2018 Jan 1:4563218760351. Epub 2018 Jan 1.
    1 26928 CHRU de Tours , Laboratoire de Biochimie et Biologie Moléculaire, Tours, France.
    Objectives Autism spectrum disorders and intellectual disability present a challenge for therapeutic and dietary management. We performed a re-analysis of plasma amino acid chromatography of children with autism spectrum disorders ( n = 22) or intellectual disability ( n = 29) to search for a metabolic signature that can distinguish individuals with these disorders from controls ( n = 30). Methods We performed univariate and multivariate analyses using different machine learning strategies, from the raw data of the amino acid chromatography. Read More

    ANNALS EXPRESS: The bone remodelling cycle.
    Ann Clin Biochem 2018 Jan 1:4563218759371. Epub 2018 Jan 1.
    Imperial College London.
    The bone remodelling cycle replaces old and damaged bone and is a highly regulated, lifelong process essential for preserving bone integrity and maintaining mineral homeostasis. During the bone remodelling cycle osteoclastic resorption is tightly coupled to osteoblastic bone formation. The remodelling cycle occurs within the Basic Multicellular Unit and comprises five co-ordinated steps; activation, resorption, reversal, formation and termination. Read More

    Falsely elevated plasma metanephrine in patients taking midodrine.
    Ann Clin Biochem 2018 Jan 1:4563218755817. Epub 2018 Jan 1.
    1 Department of Endocrinology, 47692 Oxford Centre for Diabetes, Endocrinology and Metabolism , University of Oxford, Oxford, UK.
    Plasma metanephrines have become the biochemical test of choice for suspected phaeochromocytomas and paragangliomas in many institutions. We encountered two separate cases of significantly elevated plasma metanephrines in patients taking midodrine, a sympathomimetic drug used in the treatment of severe postural hypotension, in the absence of a diagnosis of phaeochromocytomas and paragangliomas. Upon stopping midodrine treatment, plasma metanephrine concentrations returned to normal in both patients. Read More

    Diagnostic and prognostic potential of serum miR-132/212 cluster in patients with hepatocellular carcinoma.
    Ann Clin Biochem 2018 Jan 1:4563218755815. Epub 2018 Jan 1.
    2 Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
    Background It has been reported that both of the miR-132/212 (micro-RNA) cluster members, miR-132 and miR-212, are downregulated in hepatocellular carcinoma. Nevertheless, the expression pattern and clinical utility of serum miR-132/212 in hepatocellular carcinoma are still unknown. Methods In this study, serum concentrations of miR-132 and miR-212 were measured in 80 hepatocellular carcinoma patients, 51 controls with chronic liver diseases and 42 healthy volunteers by using quantitative real-time polymerase chain reaction. Read More

    Difference of seasonal variation between glycated albumin and glycated haemoglobin.
    Ann Clin Biochem 2018 Jan 1:4563218755816. Epub 2018 Jan 1.
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
    Background Glycated albumin reflects 2-3-week glycaemic controls, and in addition to glycated haemoglobin, it has been used as a glycaemic control indicator. We presumed that glycated albumin also has seasonal variations and is related to temperature, similar to glycated haemoglobin. Methods The subjects were diabetic outpatients from April 2007 to March 2013. Read More

    Valid analytical performance specifications for combined analytical bias and imprecision for the use of common reference intervals.
    Ann Clin Biochem 2018 Jan 1:4563217752963. Epub 2018 Jan 1.
    6 Department of Research, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark.
    Background Many clinical decisions are based on comparison of patient results with reference intervals. Therefore, an estimation of the analytical performance specifications for the quality that would be required to allow sharing common reference intervals is needed. The International Federation of Clinical Chemistry (IFCC) recommended a minimum of 120 reference individuals to establish reference intervals. Read More

    Predictive role of tear protein expression in the early diagnosis of Sjögren's syndrome.
    Ann Clin Biochem 2018 Jan 1:4563217750679. Epub 2018 Jan 1.
    1 Ophthalmology Unit, DIMES, University of Bologna, Bologna, Italy.
    Background The contribution of tear protein expression in patients with presumed diagnosis of Sjögren syndrome is underestimated. We aimed to evaluate the role of tear proteins in the Sjögren syndrome early diagnosis. Methods Charts from 110 patients suspected of Sjögren syndrome were analysed and the subsequent diagnosis retrieved. Read More

    Unwanted road to anaemia in transthyretin familial amyloid polyneuropathy may continue irrespective of tafamidis treatment.
    Ann Clin Biochem 2018 Jan 1:4563218754587. Epub 2018 Jan 1.
    2 Department of Neurology, Kumamoto University, Graduate School of Medical Sciences, Kumamoto, Japan.
    Background This retrospective longitudinal study was performed to determine whether tafamidis treatment leads to improvements in commonly used blood data for transthyretin familial amyloid polyneuropathy (TTR-FAP). Methods Commonly used blood data (complete blood count [including a haemogram], total protein, albumin, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transpeptidase, total bilirubin [T-Bil], creatine kinase, choline esterase, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, estimated glomerular filtration rate [eGFR], serum amyloid A protein, TTR, haemoglobin A1c, free triiodothyronine [FT3] and free thyroxine [FT4]) were investigated in 33 TTR-FAP patients. These values included longitudinal data at three time points: six months before or after tafamidis treatment and one year after tafamidis treatment. Read More

    Evaluation of cellulose pads as a method to detect cytomegalovirus DNA in neonatal urine.
    Ann Clin Biochem 2018 Jan 1:4563217750183. Epub 2018 Jan 1.
    1 Department of Neonatology and Pediatric Critical Care Medicine, University Children's Hospital Bonn, Bonn, Germany.
    Background Several approaches exist to screen neonates for congenital cytomegalovirus infection. We here describe a new method using cellulose pads for urine collection and its evaluation in an experimental and a clinical setting. Methods We systematically tested the effect of storage duration of the pads after exposure to cytomegalovirus-positive urine, meconium contamination and specimen handling on the cytomegalovirus load and the detection rate. Read More

    Assessing the cost-effectiveness of a routine versus an extensive laboratory work-up in the diagnosis of anaemia in Dutch general practice.
    Ann Clin Biochem 2018 Jan 1:4563217748984. Epub 2018 Jan 1.
    1 Department of Health Technology and Services Research, MIRA Institute for Biomedical Technology and Technical Medicine, 3230 University of Twente , Enschede, the Netherlands.
    Background Establishing the underlying cause of anaemia in general practice is a diagnostic challenge. Currently, general practitioners individually determine which laboratory tests to request (routine work-up) in order to diagnose the underlying cause. However, an extensive work-up (consisting of 14 tests) increases the proportion of patients correctly diagnosed. Read More

    The effectiveness of a routine versus an extensive laboratory analysis in the diagnosis of anaemia in general practice.
    Ann Clin Biochem 2018 Jan 1:4563217748680. Epub 2018 Jan 1.
    1 Department of Internal Medicine, 2998 Albert Schweitzer Hospital , Dordrecht, the Netherlands.
    Background We investigated the percentage of patients diagnosed with the correct underlying cause of anaemia by general practitioners when using an extensive versus a routine laboratory work-up. Methods An online survey was distributed among 836 general practitioners. The survey consisted of six cases, selected from an existing cohort of anaemia patients ( n = 3325). Read More

    A study of high-, middle- and low-molecular weight adiponectin in urine as a surrogate marker for early diabetic nephropathy using ultrasensitive immune complex transfer enzyme immunoassay.
    Ann Clin Biochem 2018 Jan 1:4563217748681. Epub 2018 Jan 1.
    2 Life Style Diseases, Institute for Health Sciences, Tokushima Bunri University, Tokushima, Japan.
    Background For the early identification of patients at risk of developing diabetic nephropathy, we have developed an ultrasensitive immune complex transfer enzyme immunoassay to measure adiponectin in urine. Methods We developed immune complex transfer enzyme immunoassay for adiponectin and measured urinary adiponectin from 70 healthy subjects, 35 obese non-diabetic subjects and 20 patients with diabetes. Results The urinary adiponectin concentrations in patients with diabetes (3. Read More

    High-sensitivity cardiac troponin concentrations at emergency department presentation in females and males with an acute cardiac outcome.
    Ann Clin Biochem 2017 Jan 1:4563217743997. Epub 2017 Jan 1.
    5 Division of Cardiology, and Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
    Background There is interest in utilizing different cut-offs per sex for high-sensitivity cardiac troponin I (hs-cTnI) but less so for high-sensitivity cardiac troponin T (hs-cTnT) for patient management in the acute setting. Our objective was to assess if differences in hs-cTn concentrations exist between males and females for an acute cardiac outcome following the presentation measurement in the emergency department. Methods An observational emergency department population with hs-cTn measurements (Roche Diagnostics and Abbott Diagnostics) at presentation with seven-day outcomes for a composite acute cardiac outcome (i. Read More

    Development of a simple indocyanine green measurement method using an automated biochemical analyser.
    Ann Clin Biochem 2017 Jan 1:4563217745895. Epub 2017 Jan 1.
    1 92154 Division of Laboratory Medicine , Chiba University Hospital, Chiba, Japan.
    Background The indocyanine green retention rate is important for assessing the severity of liver disorders. In the conventional method, blood needs to be collected twice. In the present study, we developed an automated indocyanine green method that does not require blood sampling before intravenous indocyanine green injections and is applicable to an automated biochemical analyser. Read More

    Large abnormal peak on capillary zone electrophoresis due to contrast agent.
    Ann Clin Biochem 2017 Jan 1:4563217745896. Epub 2017 Jan 1.
    1 Protein Reference Unit, South West London Pathology, St George's University Hospitals NHS Foundation Trust, London, UK.
    Background Some iodinated radio-contrast media absorb ultraviolet light and can therefore be detected by capillary zone electrophoresis. If seen, these peaks are typically small with 'quantifications' of below 5 g/L. Here, we describe the detection of a large peak on capillary zone electrophoresis that was due to the radio-contrast agent, Omnipaque™. Read More

    An inductively coupled plasma mass spectrometry method for relative free copper determination and generation of a paediatric reference interval.
    Ann Clin Biochem 2017 Jan 1:4563217744809. Epub 2017 Jan 1.
    Department of Clinical Biochemistry, 105634 University Hospital Southampton , Southampton, UK.
    Background Diagnosis of Wilson's disease is currently performed using caeruloplasmin as a first-line screening test; however, this test has well-described limitations. Monitoring of known Wilson's disease patients often uses 24-h urine collection; however, this is inaccurate in children. Methods for directly measuring plasma free copper have been described, but no reference interval data exist for a paediatric population. Read More

    Gestational age-specific reference intervals for 15 biochemical measurands during normal pregnancy in China.
    Ann Clin Biochem 2017 Jan 1:4563217738801. Epub 2017 Jan 1.
    2 Henan Human Sperm Bank, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
    Aims Physiological changes that occur during pregnancy can influence biochemical parameters. Therefore, using reference intervals based on specimens from non-pregnant women to interpret laboratory results during pregnancy may be inappropriate. This study aimed to establish the essential reference intervals for a range of analytes during pregnancy. Read More

    Performance of autotaxin as a serum marker for liver fibrosis.
    Ann Clin Biochem 2017 Jan 1:4563217741509. Epub 2017 Jan 1.
    1 Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
    Background Because autotaxin reportedly has a better performance than hyaluronic acid as a marker for liver fibrosis for the prediction of cirrhosis caused by hepatitis C, we aimed to further evaluate the role of autotaxin in liver fibrosis of other aetiologies. Methods Autotaxin antigen was measured in serum samples from 108 patients with chronic hepatitis B and 128 patients with non-alcoholic fatty liver disease who had undergone a liver biopsy as well as healthy subjects and patients with chronic kidney disease, diabetes mellitus, rheumatoid arthritis and cardiac dysfunction. Results When evaluated using receiver operator characteristics curves, the performance of autotaxin for the prediction of significant fibrosis (F2-F4) in chronic hepatitis B patients was better than that of hyaluronic acid or type IV collagen 7S. Read More

    Dysregulation of serum microRNA-574-3p and its clinical significance in hepatocellular carcinoma.
    Ann Clin Biochem 2017 Jan 1:4563217741908. Epub 2017 Jan 1.
    1 Laboratory Medicine Center, Affiliated Hospital of Nantong University, Nantong, JS, P. R. China.
    Objectives To explore microRNA-574-3p expression in serum of patients with hepatocellular carcinoma and investigate correlations between serum microRNA-574-3p expression and the development and prognosis of hepatocellular carcinoma. Design and methods Serum samples were collected from 70 patients with primary hepatocellular carcinoma, 40 patients with cirrhosis and 45 healthy controls. Serum microRNA-574-3p expression levels were detected by real-time quantitative polymerase chain reaction. Read More

    Effects of birth weight on profiles of dried blood amino-acids and acylcarnitines.
    Ann Clin Biochem 2018 Jan 9;55(1):92-99. Epub 2017 Mar 9.
    Department of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
    Background Birth weight influences profiles of dried blood amino-acids and acylcarnitines in newborn screening. This study aimed to define a more appropriate cut-off value to reduce the false positive rate and the number of recalled patients in newborn screening. Methods All babies who underwent newborn screening in our center were included; they were divided into groups by birth weight: 2500-3999 g (comparator group), <1000 g (group 1), 1000-1499 g (group 2), 1500-2499 g (group 3), and >4000 g (group 4). Read More

    Biomarkers in mesothelioma.
    Ann Clin Biochem 2018 Jan 13;55(1):49-58. Epub 2017 Nov 13.
    Academic Respiratory Unit, School of Clinical Sciences, University of Bristol, Bristol, UK.
    Mesothelioma is an aggressive cancer of pleural and peritoneal cells that is difficult to diagnose and monitor. Numerous studies have attempted to identify a blood- or pleural fluid-based biomarker that could be used in the diagnostic pathway. More recently, there has been interest in the ability of serum/plasma biomarkers to monitor mesothelioma, given the development of newer treatments and limitations of radiological assessment. Read More

    Biochemistry of the menopause.
    Ann Clin Biochem 2018 Jan 2;55(1):18-33. Epub 2017 Nov 2.
    Institute of Women's Health, University College London, London, UK.
    The life of a human female is characterized from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the perimenopause. Read More

    Clinical evaluation and treatment of phaeochromocytoma.
    Ann Clin Biochem 2018 Jan 8;55(1):34-48. Epub 2017 Nov 8.
    4 Department of Endocrine Surgery, Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, UK.
    Phaeochromocytoma and extra adrenal paraganglioma are rare neuroendocrine tumours and have the potential to secrete adrenaline, noradrenaline and dopamine causing a myriad of clinical symptoms. Prompt diagnosis is essential for clinicians and requires a multidisciplinary specialist approach for the clinical and laboratory investigation, diagnosis, treatment and follow-up of patients. This paper is an integrated review of the clinical and laboratory evaluation and treatment of patients suspected to have phaeochromocytoma or paraganglioma, highlighting recent developments and best practices from recent published clinical guidelines. Read More

    Serum α-melanocyte-stimulating hormone may act as a protective biomarker for non-traumatic osteonecrosis of the femoral head.
    Ann Clin Biochem 2017 Jan 1:4563217738802. Epub 2017 Jan 1.
    4 Department of Orthopedics, Linyi People's Hospital, Linyi, Shandong Province, China.
    Background The α-melanocyte-stimulating hormone (α-MSH), an endogenous neuropeptide derived from proopiomelanocortin (POMC), has been identified to suppress inflammation and prevent osteoblast damage. Objective The present study was aimed to investigate the role of serum α-MSH in non-traumatic osteonecrosis of the femoral head (ONFH). Methods Seventy-nine patients diagnosed with non-traumatic ONFH and 79 sex- and age-matched healthy controls were enrolled in the study. Read More

    A combined liquid chromatography tandem mass spectrometry assay for the quantification of urinary oxalate and citrate in patients with nephrolithiasis.
    Ann Clin Biochem 2017 Jan 1:4563217739035. Epub 2017 Jan 1.
    Department of Clinical Biochemistry, 5295 Manchester University NHS Foundation Trust , Manchester, UK.
    Background Analysis of citrate and oxalate in a 24-h urine sample is important in the screening and monitoring of patients with nephrolithiasis. To streamline the analytical process, it was decided to combine oxalate and citrate and analyse them simultaneously in the same assay. Objective A highly sensitive and specific assay for analysis of urine citrate and oxalate was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with a simple weak anion exchange solid phase extraction (WAX SPE) clean-up procedure. Read More

    Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations.
    Ann Clin Biochem 2017 Jan 1:4563217734883. Epub 2017 Jan 1.
    4 Coronary Care Unit, Hamilton General Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.
    Background Analytical comparisons between different high-sensitivity cardiac troponin (hs-cTn) assays are important for reassurance of results performed with different methodologies and to identify potential interferences or confounders to result interpretation. Our objective in the present study was to compare Beckman Coulter's latest hs-cTnI assay to Abbott's hs-cTnI assay and to assess agreement between results. Methods Two hundred ethylenediaminetetraacetic acid plasma samples that had clinically reported hs-cTnI results from the Abbott ARCHITECTi2000 that spanned the analytical range were stored (median = 4 h), re-centrifuged and retested for hs-cTnI on the Abbott ARCHITECTi1000 and Beckman Coulter Access2 analysers. Read More

    Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population.
    Ann Clin Biochem 2017 Jan 1:4563217735124. Epub 2017 Jan 1.
    5 Department of Public Health, Fujita Health University School of Health Sciences, Toyoake, Japan.
    Purpose It has been demonstrated that circulating microRNA profiles are affected by physiological conditions. Several studies have demonstrated that microRNAs play important roles in the regulation of adiposity. However, few have investigated the relationship between circulating microRNAs and obesity, which has become a major public health problem worldwide. Read More

    Evaluation of the revised Schwartz creatinine-based glomerular filtration rate estimating equation in Black African children in KwaZulu-Natal, South Africa.
    Ann Clin Biochem 2017 Jan 1:4563217734573. Epub 2017 Jan 1.
    1 Department of Chemical Pathology, Nelson R Mandela Medical School, 72753 University of KwaZulu-Natal , Durban, South Africa.
    Background The use of serum creatinine equations for estimating glomerular filtration rate is well known in adults and children. We evaluated the revised Schwartz creatinine-based estimated glomerular filtration rate prediction equation in Black African children in KwaZulu-Natal, South Africa. Methods Review of medical records of all Black African patients aged 2-18 years old who have had glomerular filtration rate determined by intravenous Technetium-99 m-diethylene-triamine-pentaacetate, for the period 1 January 2010 to 31 December 2014 at the Inkosi Albert Luthuli Central Hospital, Durban, South Africa was performed. Read More

    Serum high-sensitive C-reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study.
    Ann Clin Biochem 2017 Jan 1:4563217733286. Epub 2017 Jan 1.
    4 Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Background Serum high-sensitive C-reactive protein (hs-CRP) concentrations independently predict the development of diabetes, metabolic syndrome and cardiovascular disease. However, the impact of dietary factors on serum high-sensitive C-reactive protein concentrations in diabetic patients has received limited attention. We aimed to investigate the association between dietary factors and high-sensitive C-reactive protein , among diabetic patients with and without hypertension and healthy subjects. Read More

    Development of a novel fluorescent activity assay for lecithin:cholesterol acyltransferase.
    Ann Clin Biochem 2017 Jan 1:4563217733285. Epub 2017 Jan 1.
    1 Lipoprotein Metabolism Section, Cardio-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
    Background Lecithin:cholesterol acyltransferase (LCAT) is a plasma enzyme that esterifies cholesterol. Recombinant human LCAT (rhLCAT) is now being developed as an enzyme replacement therapy for familial LCAT deficiency and as a possible treatment for acute coronary syndrome. The current 'gold standard' assay for LCAT activity involves the use of radioisotopes, thus making it difficult for routine clinical use. Read More

    Increased serum concentrations of N-carboxymethyllysine are related to the presence and the severity of rheumatoid arthritis.
    Ann Clin Biochem 2017 Jan 1:4563217733500. Epub 2017 Jan 1.
    1 Laboratory of Biochemistry, LR12ES05, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
    Background There are limited data regarding the contribution of advanced glycation end products in the presence of rheumatoid arthritis. We investigated whether serum N-carboxymethyllysine and pentosidine were related to the presence and the severity of rheumatoid arthritis. Methods Eighty patients with rheumatoid arthritis and 30 control subjects were included in a cross-sectional study. Read More

    Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays.
    Ann Clin Biochem 2017 Jan 1:4563217701777. Epub 2017 Jan 1.
    1 Melbourne Pathology, Collingwood, Australia.
    Background Biotin interference is a significant problem to which at-risk laboratories must now be attuned. We sought to systematically characterize the nature of this interference in Roche immunoassays. Methods Known concentrations of biotin were titrated into serum samples and the effects on competitive and sandwich immunoassays were analysed. Read More

    The development of an artificial stool usable for the surveillance of faecal haemoglobin testing.
    Ann Clin Biochem 2017 Jan 1:4563217732587. Epub 2017 Jan 1.
    3 1st Department of Integrated Medicine ,Saitama Medical Center, Jichi University, Saitama, Japan.
    Background Faecal occult blood testing is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods We developed a ready-to-use artificial stool made from rice flour. Read More

    Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients.
    Ann Clin Biochem 2017 Jan 1:4563217731432. Epub 2017 Jan 1.
    1 Department of Hospital Pharmacy, 12793 Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
    Background Oral prochlorperazine, a dopamine D2 receptor antagonist, is largely metabolized to sulphoxide, 7-hydroxylate and N-desmethylate by cytochrome P450s (CYPs). This study evaluated the influence of CYP genotype on the plasma dispositions of prochlorperazine and its metabolites and their relationships with antiemetic efficacy and prolactin elevation in cancer patients. Methods Forty-eight cancer patients treated with oral prochlorperazine were enrolled. Read More

    Suboptimal rise in awakening-induced cortisol is an accurate marker of cortisol insufficiency in patients with normal renal function (eGFR >60 mL/min).
    Ann Clin Biochem 2017 Jan 1:4563217732361. Epub 2017 Jan 1.
    1 4616 King's College London , London, UK.
    Background The insulin tolerance test is the gold standard for diagnosis of cortisol insufficiency. However, it is cumbersome, invasive, requires supervised hospital facilities and has unpleasant side-effects. A non-invasive outpatient-based test will be useful. Read More

    Associations between glycaemic control and activation of the renin-angiotensin-aldosterone system in participants with type 2 diabetes mellitus and hypertension.
    Ann Clin Biochem 2017 Jan 1:4563217728964. Epub 2017 Jan 1.
    4 Department of Clinical Biochemistry, Galway University Hospitals, Galway, Ireland.
    Introduction Hyperglycaemia increases succinate concentrations and succinate receptor activation in the kidney resulting in renin release. The aim of our study was to determine if there is an association between glycaemic control as evidenced by glycated haemoglobin values and activation of the renin-angiotensin-aldosterone system in patients with type 2 diabetes mellitus and hypertension. Methods A cross-sectional study was conducted at Galway University Hospitals between December 2014 and March 2015. Read More

    Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity.
    Ann Clin Biochem 2017 Jan 1:4563217727015. Epub 2017 Jan 1.
    Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
    Background Henoch-Schonlein purpura is a systemic small-vessel vasculitis that occurs mainly in children. A review of the literature has suggested a correlation between mean platelet volume and several inflammatory disorders. However, to the best of our knowledge, any potential correlation between mean platelet volume and Henoch-Schonlein purpura has not been reported in the literature. Read More

    Prediction of haematocrit in dried blood spots from the measurement of haemoglobin using commercially available sodium lauryl sulphate.
    Ann Clin Biochem 2017 Jan 1:4563217726809. Epub 2017 Jan 1.
    Department of Clinical Biochemistry, University Hospital of South Manchester, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
    Background When preparing dried blood spots (DBSs), haematocrit (Hct) can affect the ability of the blood to spread through the filter paper, thus resulting in varying quantities of sample being measured when fixed subpunches of the DBSs are taken. It may be important to predict the sample Hct to correct volume differences. Methods Blood (10  µL) was applied to Perkin Elmer 226® paper. Read More

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