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    4583 results match your criteria Annals of clinical biochemistry[Journal]

    1 OF 92

    ANNALS EXPRESS: Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations.
    Ann Clin Biochem 2017 Jan 1:4563217734883. Epub 2017 Jan 1.
    McMaster University.
    Background: Analytical comparisons between different high-sensitivity cardiac troponin (hs-cTn) assays are important for reassurance of results performed with different methodologies and to identify potential interferences or confounders to result interpretation. Our objective in the present study was to compare Beckman Coulter's latest hs-cTnI assay to Abbott's hs-cTnI assay and to assess agreement between results.

    Methods: Two hundred EDTA plasma samples that had clinically reported hs-cTnI results from the Abbott ARCHITECTi2000 that spanned the analytical range were stored (median=4h), re-centrifuged and retested for hs-cTnI on the Abbott ARCHITECTi1000 and Beckman Coulter Access2 analyzers. Read More

    ANNALS EXPRESS: Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population.
    Ann Clin Biochem 2017 Jan 1:4563217735124. Epub 2017 Jan 1.
    Fujita Health University School of Health Sciences.
    Purpose It has been demonstrated that circulating microRNA (miRNA) profiles are affected by physiological conditions. Several studies have demonstrated that miRNAs play important roles in the regulation of adiposity. However, few have investigated the relationship between circulating miRNAs and obesity, which has become a major public health problem worldwide. Read More

    ANNALS EXPRESS: Evaluation of common paediatric creatinine based glomerular filtration rate (GFR) estimating equations in Black African children in KwaZulu-Natal, South Africa.
    Ann Clin Biochem 2017 Jan 1:4563217734573. Epub 2017 Jan 1.
    University of KwaZulu-Natal College of Health Sciences.
    Background The use of serum creatinine (S-Cr) equations for estimating glomerular filtration rate (GFR) is well known in adults and children. We evaluated the revised Schwartz creatinine based estimated GFR (eGFR) prediction equation in Black African children in KwaZulu-Natal, South Africa. Methods Review of medical records of all Black African patients aged 2-18 years old who have had GFR determined by intravenous Technetium-99m-diethylene-triamine-pentaacetate((9)(9)(m)Tc DTPA), for the period 1 January 2010 to 31 December 2014 at the Inkosi Albert Luthuli Central Hospital (IALCH), Durban, South Africa was performed. Read More

    ANNALS EXPRESS: Serum high sensitive C reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study.
    Ann Clin Biochem 2017 Jan 1:4563217733286. Epub 2017 Jan 1.
    Brighton and Sussex Medical School.
    Background: Serum high sensitive C-reactive protein (hs-CRP) concentrations independently predict the development of diabetes, metabolic syndrome and cardiovascular disease. However, the impact of dietary factors on serum hs-CRP concentrations in diabetic patients has received limited attention. We aimed to investigate the association between dietary factors and hs-CRP, among diabetic patients with and without hypertension and healthy subjects. Read More

    ANNALS EXPRESS: Development of a Novel Fluorescent Activity Assay for Lecithin:cholesterol Acyltransferase.
    Ann Clin Biochem 2017 Jan 1:4563217733285. Epub 2017 Jan 1.
    Lipoprotein Metabolism Section, Cardio-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.

    ANNALS EXPRESS: Increased serum concentrations of Nξ-carboxymethyllysine are related to presence and severity of rheumatoid arthritis.
    Ann Clin Biochem 2017 Jan 1:4563217733500. Epub 2017 Jan 1.
    Institut Superieur de Biotechnologie de Monastir.
    Background: there are limited data regarding the contribution of advanced glycation end products (AGEs) in the presence of rheumatoid arthritis (RA). We investigated whether serum N-carboxymethyllysine (CML) and pentosidine were related to the presence and the severity of RA.

    Methods: Eighty patients with RA and 30 control subjects were included in a cross-sectional study. Read More

    Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays.
    Ann Clin Biochem 2017 Jan 1:4563217701777. Epub 2017 Jan 1.
    1 Melbourne Pathology, Collingwood, Australia.
    Background Biotin interference is a significant problem to which at-risk laboratories must now be attuned. We sought to systematically characterize the nature of this interference in Roche immunoassays. Methods Known concentrations of biotin were titrated into serum samples and the effects on competitive and sandwich immunoassays were analysed. Read More

    ANNALS EXPRESS: The development of an artificial stool usable for the surveillance of fecal hemoglobin testing.
    Ann Clin Biochem 2017 Jan 1:4563217732587. Epub 2017 Jan 1.
    Saitama Medical Center, Jichi Medical School.
    Backgrounds; Fecal occult blood testing (FOBT) is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods; We developed a ready-to-use artificial stool made from rice flour. Read More

    ANNALS EXPRESS: Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients.
    Ann Clin Biochem 2017 Jan 1:4563217731432. Epub 2017 Jan 1.
    Hamamatsu University School of Medicine.
    Background: Oral prochlorperazine, a dopamine D2 receptor antagonist, is largely metabolized to sulfoxide, 7-hydroxylate, and N-desmethylate by cytochrome P450s (CYPs). This study evaluated the influence of CYP genotype on the plasma dispositions of prochlorperazine and its metabolites and their relationships with antiemetic efficacy and prolactin elevation in cancer patients.

    Methods: Forty-eight cancer patients treated with oral prochlorperazine were enrolled. Read More

    ANNALS EXPRESS: Sub-optimal rise in awakening induced cortisol is an accurate marker of cortisol insufficiency in patients with normal renal function (eGFR > 60 ml/min).
    Ann Clin Biochem 2017 Jan 1:4563217732361. Epub 2017 Jan 1.
    St Thomas Hospital.
    Background: The insulin tolerance test (ITT) is the gold standard for diagnosis of cortisol insufficiency. However, it is cumbersome, invasive, requires supervised hospital facilities and has unpleasant side-effects. A non-invasive out-patient based test will be useful. Read More

    ANNALS EXPRESS: Associations between glycaemic control and activation of the Renin Angiotensin Aldosterone System in participants with Type 2 Diabetes Mellitus and Hypertension.
    Ann Clin Biochem 2017 Jan 1:4563217728964. Epub 2017 Jan 1.
    Galway University Hospitals.
    Introduction: Hyperglycaemia increases succinate levels and succinate receptor (GPR91) activation in the kidney resulting in renin release. The aim of our study was to determine if there is an association between glycaemic control as evidenced by glycated haemoglobin (HbA1c) values and activation of the renin-angiotensin-aldosterone-system in patients with type 2 diabetes mellitus (T2DM) and hypertension.

    Methods: A cross-sectional study was conducted at Galway University Hospitals between December 2014 and March 2015. Read More

    Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity.
    Ann Clin Biochem 2017 Jan 1:4563217727015. Epub 2017 Jan 1.
    Department of Clinical Laboratory, the First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
    Background Henoch-Schonlein purpura is a systemic small-vessel vasculitis that occurs mainly in children. A review of the literature has suggested a correlation between mean platelet volume and several inflammatory disorders. However, to the best of our knowledge, any potential correlation between mean platelet volume and Henoch-Schonlein purpura has not been reported in the literature. Read More

    Prediction of haematocrit in dried blood spots from the measurement of haemoglobin using commercially available sodium lauryl sulphate.
    Ann Clin Biochem 2017 Jan 1:4563217726809. Epub 2017 Jan 1.
    Department of Clinical Biochemistry, University Hospital of South Manchester, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
    Background When preparing dried blood spots (DBSs), haematocrit (Hct) can affect the ability of the blood to spread through the filter paper, thus resulting in varying quantities of sample being measured when fixed subpunches of the DBSs are taken. It may be important to predict the sample Hct to correct volume differences. Methods Blood (10  µL) was applied to Perkin Elmer 226® paper. Read More

    Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis.
    Ann Clin Biochem 2017 Jan 1:4563217726808. Epub 2017 Jan 1.
    3 School of Medicine, University of Zagreb, Zagreb, Croatia.
    Introduction Despite some new treatment possibilities, the improvement in survival rate for hepatocellular carcinoma (HCC) patients is still poor due to late diagnosis. The aim of this study was to investigate the diagnostic sensitivity and specificity of protein induced by vitamin K absence or antagonist-II (PIVKAII), Glypican-3 (GP3), Cystatin B (CSTB), squamous cell carcinoma antigen 1 (SCCA1) and hepatocyte growth factor (HGF) as potential tumour markers for HCC in patients with alcoholic liver cirrhosis (ALC) using imaging techniques (MSCT and MRI) as reference standards. Patients and methods Eighty-three participants were included: 20 healthy volunteers, 31 patients with ALC and 32 patients with HCC. Read More

    False-negative results in the immunoassay analysis of drugs of abuse: can adulterants be detected by sample check test?
    Ann Clin Biochem 2017 Jan 1:4563217725089. Epub 2017 Jan 1.
    2 Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany.
    Background The dilution or adulteration of urine is a serious problem in drugs of abuse testing. Tests to identify adulteration are currently available. This study investigated the ability of the CEDIA® sample check to detect adulteration. Read More

    20α- and 20β-dihydrocortisone may interfere in LC-MS/MS determination of cortisol in saliva and urine.
    Ann Clin Biochem 2017 Jan 1:4563217724178. Epub 2017 Jan 1.
    1 Clinical Chemistry, Institution for Medical Biosciences, Umeå University, Umeå, Sweden.
    Background LC-MS/MS methods offer high selectivity in cortisol determinations. However, endogenous steroid metabolites may still interfere and compromise the results, for example in the diagnosis of Cushing's syndrome. Erroneously elevated cortisol may, in particular, be misleading at the low concentrations found in salivary samples obtained at late night and after dexamethasone suppression. Read More

    ANNALS EXPRESS: Experience with newer central nervous system autoantibodies.
    Ann Clin Biochem 2017 Jan 1:4563217724818. Epub 2017 Jan 1.
    University Hospital Birmingham NHS Foundation Trust.
    In the last decade, a large number of neuronal cell-surface antibodies have been described which are responsible for a range of neuroimmunological central nervous system disorders. Unlike the paraneoplastic antibodies which target intracellular antigens, these antibodies appear to be pathogenic and hence identification and prompt treatment can make a substantial impact on clinical outcomes of these patients. We review the common antibodies against the ionotropic Glutamate receptors (NMDAR, AMPAR), metabotropic Glutamate receptors (mGluR1 and mGluR5), voltage gated potassium channel-complex proteins (LGI1, CASPR2), and other antibodies targeted against Glycine receptor, Glutamic acid decarboxylase (GAD), Gamma Amino Butyric Acid B (GABAB), Dopamine-2-receptor (D2R) and Dipeptidyl-peptidase-like protein 6 (DPPX). Read More

    Application of NICE guideline NG12 to the initial assessment of patients with lower gastrointestinal symptoms: not FIT for purpose?
    Ann Clin Biochem 2017 Jan 1:4563217707981. Epub 2017 Jan 1.
    1 Centre for Research into Cancer Prevention and Screening, University of Dundee, Dundee, UK.
    Background The National Institute for Health and Care Excellence (NICE) published NG12 in 2015. The referral criteria for suspected colorectal cancer (CRC) caused controversy, because tests for occult blood in faeces were recommended. Faecal immunochemical tests for haemoglobin (FIT), which estimate faecal haemoglobin concentrations (f-Hb), might more than fulfil the intentions. Read More

    Demand management by electronic gatekeeping of test requests does not influence requesting behaviour or save costs dramatically.
    Ann Clin Biochem 2017 Jan 1:4563217707980. Epub 2017 Jan 1.
    1 Department of Chemical Pathology, Faculty of Health Sciences, University of Pretoria and National Health Laboratory Service, Tshwane Academic Division, Pretoria, South Africa.
    Background Healthcare budgets face constraints, and laboratories have developed strategies to adapt to the concomitant increase in workload. Some of the tests (7.4%) may be attributed to unnecessary repeat testing. Read More

    Diagnostic accuracy of the Coopscore(©) to predict liver fibrosis in human immunodeficiency virus/hepatitis B virus co-infection.
    Ann Clin Biochem 2017 Jan 1:4563217707979. Epub 2017 Jan 1.
    1 Pôle de Biologie Médicale et Pathologie, Hôpitaux Universitaire de l'Est Parisien, site Saint-Antoine, Paris, France.
    Background Non-invasive methods for assessing liver fibrosis are increasingly used as an alternative to liver biopsy. Recently, a score-based biochemical blood test (Coopscore(©)) was developed in a cohort of patients chronically infected with hepatitis C virus, showing higher diagnostic performances than Fibrometer®, Fibrotest®, Hepascore® and Fibroscan™. Here, we assess its performance in patients co-infected with the human immunodeficiency virus and hepatitis B virus. Read More

    Decreased serum glicentin concentration in patients with severe and morbid obesity.
    Ann Clin Biochem 2017 Jan 1:4563217700172. Epub 2017 Jan 1.
    1 Clinical Chemistry Laboratory, University Hospital of Nice, Nice, France.
    Background Proglucagon-derived hormones represent a family of peptides mainly produced in the pancreas and the intestine. While several proglucagon-derived peptides play key roles in metabolic diseases, little is known about glicentin. The aim of the present study was to investigate serum glicentin concentrations in individuals with adult obesity and to study its potential link with various metabolic parameters. Read More

    Urinary albumin: a risk marker under-requested in primary care in Spain.
    Ann Clin Biochem 2017 Jan 1:4563217716475. Epub 2017 Jan 1.
    4 Department of Radiology, University of Virginia, Charlottesville, VA, USA.
    Background To study the inter-practice regional variation in the request of urinary albumin by general practitioners and compare to guideline recommendations. Methods A cross-sectional study enrolled laboratories from different Spanish autonomous communities. Laboratories were invited to report the number of urinary albumin requested by general practitioners during 2012 and 2014. Read More

    Foetal haemoglobin concentration at postmenstrual age is unaffected by gestational age at birth.
    Ann Clin Biochem 2017 Jan 1:4563217721253. Epub 2017 Jan 1.
    2 Infection Control and Prevention, Kobe University Hospital, Kobe, Japan.
    Background Our aim was to determine whether the postnatal age or postmenstrual age is a more appropriate criterion for evaluating foetal haemoglobin concentrations. Methods Blood samples ( n = 1095) were obtained from 394 infants and were divided into two groups based on gestational age at birth: <37 weeks ( n = 491) and ≥37 weeks ( n = 604). (1) Foetal haemoglobin concentrations divided by one month at age after birth were compared between the groups. Read More

    ANNALS EXPRESS: High Sensitivity Troponin T and I reflect Left Atrial Function being assessed by Cardiac Magnetic Resonance Imaging (cMRI).
    Ann Clin Biochem 2017 Jan 1:4563217714004. Epub 2017 Jan 1.
    Clinic Nuremberg.
    Background: Left atrial function (LAF) plays an interactive role between pulmonary and systemic circulation. Cardiac biomarkers, such as amino-terminal pro-brain natriuretic peptide (NT-proBNP) and troponins, might reflect cardiac function. This study aims to evaluate the association between high sensitivity troponins (hsTn) and LAF in patients undergoing cMRI. Read More

    Quantitative measurement of a candidate serum biomarker peptide derived from α2-HS-glycoprotein, and a preliminary trial of multidimensional peptide analysis in females with pregnancy-induced hypertension.
    Ann Clin Biochem 2017 Jan 1:4563217717748. Epub 2017 Jan 1.
    1 Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan.
    Purpose We previously attempted to develop quantitative enzyme-linked immunosorbent assay (ELISA) systems for the PDA039/044/071 peptides, potential serum disease biomarkers (DBMs) of pregnancy-induced hypertension (PIH), primarily identified by a peptidomic approach (BLOTCHIP®-mass spectrometry (MS)). However, our methodology did not extend to PDA071 (cysteinyl α2-HS-glycoprotein341-367), due to difficulty to produce a specific antibody against the peptide. The aim of the present study was to establish an alternative PDA071 quantitation system using liquid chromatography-multiple reaction monitoring (LC-MRM)/MS, to explore the potential utility of PDA071 as a DBM for PIH. Read More

    Newborn screening for sickle cell disorders using tandem mass spectrometry: three years' experience of using a protocol to detect only the disease states.
    Ann Clin Biochem 2017 Sep 17;54(5):601-611. Epub 2017 Jul 17.
    5 Screening Division, Public Health Wales, Cardiff, UK.
    Background Tandem mass spectrometry (MS/MS) has recently become an alternative method for the newborn screening of sickle cell disorders (SCD), as it is able to detect haemoglobin (Hb) peptides following digestion of bloodspots with trypsin. Using the SpOtOn Diagnostics Reagent Kit, we previously developed a screening protocol to detect only the disease states of SCD, using action values based on the ratio between the variant Hb peptide to wild-type peptide abundances for the HbS, C, D(Punjab), O(Arab), E and Lepore peptides. Methods Action values using the ratios between the wild type HbA (ßT1-3) peptides and the foetal Hb (γT2) peptide were developed to identify bloodspot samples from premature and transfused infants. Read More

    Effects of bilirubin photoisomers on the measurement of direct bilirubin by the bilirubin oxidase method.
    Ann Clin Biochem 2017 Jan 1:4563217716474. Epub 2017 Jan 1.
    1 Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
    Background We occasionally encounter increases in direct bilirubin value on reanalysis of the surplus serum collected in the past from a neonate with indirect hyperbilirubinemia. But the details of this phenomenon are unclear. We evaluated the change of direct bilirubin and the relation of bilirubin photoisomer of the serum exposed to room light. Read More

    Changes in the albumin glycation site, plasma pentosidine and esRAGE concentrations before and after intensive diabetic treatment in patients with abnormally high glycated albumin levels.
    Ann Clin Biochem 2017 Jan 1:4563216687787. Epub 2017 Jan 1.
    1 Division of Central Laboratory, Daisan Hospital, Jikei University School of Medicine, Tokyo, Japan.
    Background We have reported that the blood glucose normalization treatment reduced the albumin glycation sites and the intensity of albumin AGE fluorescence in patients with abnormally high glycated albumin levels. To clarify the relationship between glycaemic control status and levels of glycated proteins and related markers, we studied the change of the markers of the DM patients with and without fatty liver, liver cirrhosis and dialysis before and after the intensive diabetic treatment. Methods Eight diabetic patients with abnormally high glycated albumin levels (no complications: 2, fatty liver: 3, liver cirrhosis: 2, dialysis: 1) were recruited. Read More

    Mind the gap: Shortcomings of the osmotic gap and a possible solution.
    Ann Clin Biochem 2017 Jan 1:4563217694052. Epub 2017 Jan 1.
    1 Department of Chemical Pathology, The Royal Brisbane Women's and Children's Hospital, Pathology Queensland, Queensland, Australia.
    Background Measured (MO) and calculated osmotic concentrations (CO) and the osmotic gap (OG) are commonly used in the investigation of electrolyte and volume disturbances as well as in cases of suspected volatile ingestion. Methods We compared 38 published formulae for CO with MO on a large data-set ( n = 9466) and adjusted the CO with the result of a Passing-Bablok regression procedure. Validation of this adjustment was performed with a separate data-set ( n = 2082). Read More

    Age and sex differences in serum adiponectin and its association with lipoprotein fractions.
    Ann Clin Biochem 2017 Jan 1:4563217699233. Epub 2017 Jan 1.
    1 Internal Medicine of Metabolism and Nutrition, The Jikei University Graduate School of Medicine, Chiba, Japan.
    Objective The correlation of adiponectin with cholesterol concentration of fractionated lipoproteins has not been well investigated. Methods This study included 174 subjects (79 men and 95 women) without diabetes. The medical record data were investigated retrospectively. Read More

    ANNALS EXPRESS: Electrophoretic patterns post Daratumumab.
    Ann Clin Biochem 2017 Jan 1:4563217710489. Epub 2017 Jan 1.
    Parkside Cancer Centre.
    Background: Daratumumab (Darzalex) is a human IgG1 kappa monoclonal antibody targeting CD38 that has been recently approved for treatment of refractory multiple myeloma. As it is a monoclonal protein, it can be detected on routine serum protein electrophoresis and by immunofixation.

    Methods: Sera from four patients were analysed by serum protein electrophoresis immediately pre- and post-treatment with Daratumumab. Read More

    Multiple myeloma and acquired von Willebrand disease: a combined cause of preanalytical interference causing gel formation?
    Ann Clin Biochem 2017 Jan 1:4563217710488. Epub 2017 Jan 1.
    1 Department of Clinical Biochemistry, Barts Health NHS Trust, London, UK.
    We report a patient with acquired von Willebrand disease, associated with multiple myeloma. At one stage in his illness, we were unable to analyse a sample sent in a serum separator tube, due to the presence of a gel within the separated serum layer. We suggest this was due to anomalous position of the gel because of the density of the sample caused by its high total protein concentration, exacerbated by fibrin strand formation because of inhibition of appropriate fibrin clot formation secondary to clotting disorder. Read More

    Designing and evaluating autoverification rules for thyroid function profiles and sex hormone tests.
    Ann Clin Biochem 2017 Jan 1:4563217712291. Epub 2017 Jan 1.
    2 Department of Clinical Laboratory, The First Affiliated Hospital of Shantou University Medical College, Guangdong, People's Republic of China.
    Purpose Following the analytical phase, the current practice of many hospital laboratories involves the manual verification of all test results followed by the production of the report. However, manual verification is a time-consuming and tedious process. In this paper, we provide a detailed description of how to design autoverification rules for thyroid function test profiles and sex hormones. Read More

    Reactivity of bilirubin photoisomers on the measurement of direct bilirubin using vanadic acid method.
    Ann Clin Biochem 2017 Jan 1:4563217709844. Epub 2017 Jan 1.
    1 Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa, Japan.
    Objective Investigation of the reactivity of fractions of bilirubin photoisomers with the vanadic acid oxidation method. Methods Bilirubin photoisomers were prepared by irradiating a bilirubin/human serum albumin solution with blue light emitting diode. Direct bilirubin and bilirubin fractions were measured using the vanadic acid oxidation method and high-performance liquid chromatography in the sample before and after irradiation. Read More

    Depletion of biotin using streptavidin-coated microparticles: a validated solution to the problem of biotin interference in streptavidin-biotin immunoassays.
    Ann Clin Biochem 2017 Jan 1:4563217707783. Epub 2017 Jan 1.
    1 Melbourne Pathology, Collingwood, Australia.
    Background Biotin interference in streptavidin-based immunoassays causes widespread analytical distortions that may lead to clinical confusion, inappropriate patient management and, ultimately, adverse events. Its prevalence has increased recently due to the increased use of high-dose biotin therapy in specific patient groups (notably multiple sclerosis) and possibly the general community. Methods We have developed a method to deplete biotin from samples using the streptavidin-coated magnetic microparticles that are a component of most susceptible assays. Read More

    High-dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow-up study.
    Ann Clin Biochem 2017 Jan 1:4563217707784. Epub 2017 Jan 1.
    1 Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Background Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here, we explored the effects of high-dose vitamin D supplementation on cardio-metabolic risk factors. Read More

    ANNALS EXPRESS: Stimulating TSH receptor autoantibodies immunoassay: analytical evaluation and clinical performance in Graves' Disease.
    Ann Clin Biochem 2017 Jan 1:4563217700655. Epub 2017 Jan 1.
    Catholic University School of Medicine.
    Background: Thyroid stimulating hormone (TSH) receptor (TSHR) autoantibodies (TRAbs) are a heterogeneous group of antibodies (Abs) with different functionality. Among all TRAbs only the stimulating one (S-TRAbs) are considered the pathogenetic marker of Graves' Disease (GD). To date, the methods available for TRAbs testing are based on immunoassays (IMAs) which detect total serum TRAbs or bioassays which are not suitable in clinical practice, even though they discern Abs functionality. Read More

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