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    4873 results match your criteria Annals of biomedical engineering[Journal]

    1 OF 98

    Investigation of Shape with Patients Suffering from Unilateral Lymphoedema.
    Ann Biomed Eng 2017 Sep 20. Epub 2017 Sep 20.
    Zienkiewicz Centre for Computational Engineering, College of Engineering, Swansea University Bay Campus, Fabian Way, Swansea, SA1 8EN, UK.
    This study investigates the use of a 3D depth sensing camera for analysing the shape of lymphoedematous arms, and seeks to identify suitable metrics for monitoring lymphoedema clinically. A fast, simple protocol was developed for scanning upper limb lymphoedema, after which a robust data pre- and post-processing framework was built that consistently and quickly identifies arm shape and volume. The framework was then tested on 24 patients with mild unilateral lymphoedema, who were also assessed using tape measurements. Read More

    Random Electromyostimulation Promotes Osteogenesis and the Mechanical Properties of Rat Bones.
    Ann Biomed Eng 2017 Sep 19. Epub 2017 Sep 19.
    Graduate School of Natural Science and Technology, Division of Mechanical Science and Engineering, Kanazawa University, Kanazawa, Ishikawa, Japan.
    Exercise is often recommended as a promising non-pharmacologic countermeasure to prevent osteoporosis. However, elderly osteoporotic patients generally have physical fitness difficulties preventing them from performing effective and sustainable exercise. Electromyostimulation should be one effective modality for non-pharmacological prevention of osteoporosis without any voluntary physical movements. Read More

    Increasing Distribution of Drugs Released from In Situ Forming PLGA Implants Using Therapeutic Ultrasound.
    Ann Biomed Eng 2017 Sep 19. Epub 2017 Sep 19.
    Department of Radiology, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106, USA.
    One of the challenges in developing sustained-release local drug delivery systems is the limited treatment volume that can be achieved. In this work, we examine the effectiveness of using low frequency, high intensity ultrasound to promote the spatial penetration of drug molecules away from the implant/injection site boundary upon release from injectable, phase inverting poly(lactic acid-co-glycolic acid) (PLGA) implants. Fluorescein-loaded PLGA solutions were injected into poly(acrylamide) phantoms, and the constructs were treated daily for 14 days with ultrasound at 2. Read More

    A Nociceptive Role for Integrin Signaling in Pain After Mechanical Injury to the Spinal Facet Capsular Ligament.
    Ann Biomed Eng 2017 Sep 18. Epub 2017 Sep 18.
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 S. 33rd St, Philadelphia, PA, 19104-6321, USA.
    Integrins modulate chemically-induced nociception in a variety of inflammatory and neuropathic pain models. Yet, the role of integrins in mechanically-induced pain remains undefined, despite its well-known involvement in cell adhesion and mechanotransduction. Excessive spinal facet capsular ligament stretch is a common injury that induces morphological and functional changes in its innervating afferent neurons and can lead to pain. Read More

    Dual Contrast CT Method Enables Diagnostics of Cartilage Injuries and Degeneration Using a Single CT Image.
    Ann Biomed Eng 2017 Sep 18. Epub 2017 Sep 18.
    Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.
    Cartilage injuries may be detected using contrast-enhanced computed tomography (CECT) by observing variations in distribution of anionic contrast agent within cartilage. Currently, clinical CECT enables detection of injuries and related post-traumatic degeneration based on two subsequent CT scans. The first scan allows segmentation of articular surfaces and lesions while the latter scan allows evaluation of tissue properties. Read More

    Development of a High-Throughput Magnetic Separation Device for Malaria-Infected Erythrocytes.
    Ann Biomed Eng 2017 Sep 18. Epub 2017 Sep 18.
    Department of Biomedical Engineering, Carnegie Mellon University, Scott Hall 4N201, 5000 Forbes Avenue, Pittsburgh, PA, 15213, USA.
    This study describes a non-dilutive high-gradient magnetic separation (HGMS) device intended to continuously remove malaria-infected red blood cells (iRBCs) from the circulation. A mesoscale prototype device with disposable photo-etched ferromagnetic grid and reusable permanent magnet was designed with a computationally-optimized magnetic force. The prototype device was evaluated in vitro using a non-pathogenic analog for malaria-infected blood, comprised of 24% healthy RBCs, 6% human methemoglobin RBCs (metRBCs), and 70% phosphate buffer solution (PBS). Read More

    Spine Posture Influences Tactile Perceptual Sensitivity of the Trunk Dorsum.
    Ann Biomed Eng 2017 Sep 18. Epub 2017 Sep 18.
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
    The purpose of the current work was to quantify the influence of posture-mediated skin deformation on trunk dorsum tactile perceptual sensitivity. Twelve young and healthy individuals were assessed while adopting three different spine postures (extension, neutral and flexion). Tactile sensitivity threshold tests (T10 and L4 vertebral levels) included measures of touch sensitivity, spatial acuity and stretch sensitivity. Read More

    Intestinal Mechanomorphological Remodeling Induced by Long-Term Low-Fiber Diet in Rabbits.
    Ann Biomed Eng 2017 Sep 14. Epub 2017 Sep 14.
    Department of Surgery, GIOME, Chinese University of Hong Kong, Hong Kong SAR, China.
    Short-term feeding with low-fiber diet remodels the mechanomorphological properties in the rabbit small intestine. The aims were to study the effect of feeding low-fiber diet for 5 months on mechanomorphological properties including the collagen fraction in the rabbit intestines. Fifteen rabbits were divided into an Intervention group (IG, n = 10) fed a low-fiber diet and a Control group (CG, n = 5) fed a normal diet for 5 months. Read More

    Ranges of Injury Risk Associated with Impact from Unmanned Aircraft Systems.
    Ann Biomed Eng 2017 Sep 14. Epub 2017 Sep 14.
    Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
    Regulations have allowed for increased unmanned aircraft systems (UAS) operations over the last decade, yet operations over people are still not permitted. The objective of this study was to estimate the range of injury risks to humans due to UAS impact. Three commercially-available UAS models that varied in mass (1. Read More

    Fluid- and Biomechanical Analysis of Ascending Thoracic Aorta Aneurysm with Concomitant Aortic Insufficiency.
    Ann Biomed Eng 2017 Sep 13. Epub 2017 Sep 13.
    Ecole Nationale Supérieure des Mines de Saint-Etienne, CIS-EMSE, SAINBIOSE, 42023, Saint-Etienne, France.
    We present a comprehensive and original framework for the biomechanical analysis of patients affected by ascending thoracic aorta aneurysm and aortic insufficiency. Our aim is to obtain crucial indications about the role played by deranged hemodynamics on the ATAAs risk of rupture. Computational fluid dynamics analysis was performed using patient-specific geometries and boundary conditions derived from 4D MRI. Read More

    Poly-N-Acetyl Glucosamine (sNAG) Enhances Early Rotator Cuff Tendon Healing in a Rat Model.
    Ann Biomed Eng 2017 Sep 13. Epub 2017 Sep 13.
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, 110 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104-6081, USA.
    Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. Read More

    Why are Antagonist Muscles Co-activated in My Simulation? A Musculoskeletal Model for Analysing Human Locomotor Tasks.
    Ann Biomed Eng 2017 Sep 12. Epub 2017 Sep 12.
    Department of Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
    Existing "off-the-shelf" musculoskeletal models are problematic when simulating movements that involve substantial hip and knee flexion, such as the upstroke of pedalling, because they tend to generate excessive passive fibre force. The goal of this study was to develop a refined musculoskeletal model capable of simulating pedalling and fast running, in addition to walking, which predicts the activation patterns of muscles better than existing models. Specifically, we tested whether the anomalous co-activation of antagonist muscles, commonly observed in simulations, could be resolved if the passive forces generated by the underlying model were diminished. Read More

    A Novel Multi-objective Physiological Control System for Rotary Left Ventricular Assist Devices.
    Ann Biomed Eng 2017 Sep 12. Epub 2017 Sep 12.
    Department of Mechanical and Process Engineering, Product Development Group Zurich, ETH Zurich, CLA G 21.1, Tannenstrasse 3, 8092, Zurich, Switzerland.
    Various control and monitoring algorithms have been proposed to improve the left-ventricular assist device (LVAD) therapy by reducing the still-occurring adverse events. We developed a novel multi-objective physiological control system that relies on the pump inlet pressure (PIP). Signal-processing algorithms have been implemented to extract the required features from the PIP. Read More

    Nano-Composite Foam Sensor System in Football Helmets.
    Ann Biomed Eng 2017 Sep 7. Epub 2017 Sep 7.
    Department of Mechanical Engineering, Brigham Young University, Provo, USA.
    American football has both the highest rate of concussion incidences as well as the highest number of concussions of all contact sports due to both the number of athletes and nature of the sport. Recent research has linked concussions with long term health complications such as chronic traumatic encephalopathy and early onset Alzheimer's. Understanding the mechanical characteristics of concussive impacts is critical to help protect athletes from these debilitating diseases and is now possible using helmet-based sensor systems. Read More

    In Vivo Strain Analysis of Dilated Ascending Thoracic Aorta by ECG-Gated CT Angiographic Imaging.
    Ann Biomed Eng 2017 Sep 7. Epub 2017 Sep 7.
    Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT, Palermo, Italy.
    Accurate assessment of aortic extensibility is a requisite first step for elucidating the pathophysiology of an ascending thoracic aortic aneurysm (ATAA). This study aimed to develop a framework for the in vivo evaluation of the full-field distribution of the aortic wall strain by imaging analysis of electrocardiographic- (ECG) gated thoracic data of 34 patients with ATAA. Seven healthy controls (i. Read More

    Kinematic Outcome Measures using Target-Reaching Arm Movement in Stroke.
    Ann Biomed Eng 2017 Sep 7. Epub 2017 Sep 7.
    Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
    This study aimed to quantitatively investigate upper extremity motor performance and disclose the abnormality of motor control induced by stroke. Ten patients and ten healthy subjects were instructed to perform target-reaching tasks at nine difficulty levels, and coordinates of the shoulder, elbow and tip of the index finger were recorded. Age-matched control performed significantly better than patients, as indicated by lower movement time (MT) and normalized jerk score (NJS) and higher peak velocity (V peak), percentage time to peak velocity (PTPV), fuzzy approximate entropy (fApEn) and relative joint angles correlation (RJAC); also, significant effects of difficulty on all parameters except RJAC and fApEn, were observed in two groups. Read More

    The Automated Assessment of Postural Stability: Balance Detection Algorithm.
    Ann Biomed Eng 2017 Aug 30. Epub 2017 Aug 30.
    Department of Electrical & Computer Engineering, Temple University, Philadelphia, PA, 19122, USA.
    Impaired balance is a common indicator of mild traumatic brain injury, concussion and musculoskeletal injury. Given the clinical relevance of such injuries, especially in military settings, it is paramount to develop more accurate and reliable on-field evaluation tools. This work presents the design and implementation of the automated assessment of postural stability (AAPS) system, for on-field evaluations following concussion. Read More

    Objective Assessment of Bradykinesia Estimated from the Wrist Extension in Older Adults and Patients with Parkinson's Disease.
    Ann Biomed Eng 2017 Aug 29. Epub 2017 Aug 29.
    Centre for Innovation and Technology Assessment in Health, Postgraduate Program in Electrical and Biomedical Engineering, Faculty of Electrical Engineering, Federal University of Uberlândia, Uberlândia, Brazil.
    Parkinson's disease (PD) presents several motor signs, including tremor and bradykinesia. However, these signs can also be found in other motor disorders and in neurologically healthy older adults. The incidence of bradykinesia in PD is relatively high in all stages of the disorder, even when compared to tremor. Read More

    Review of Mechanical Testing and Modelling of Thrombus Material for Vascular Implant and Device Design.
    Ann Biomed Eng 2017 Aug 28. Epub 2017 Aug 28.
    Biomechanics Research Centre (BMEC), Biomedical Engineering, College of Engineering and Informatics, National University of Ireland, Galway, Ireland.
    A thrombus or blood clot is a solid mass, made up of a network of fibrin, platelets and other blood components. Blood clots can form through various pathways, for example as a result of exposed tissue factor from vascular injury, as a result of low flow/stasis, or in very high shear flow conditions. Embolization of cardiac or vascular originating blood clots, causing an occlusion of the neurovasculature, is the major cause of stroke and accounts for 85% of all stroke. Read More

    An Enhanced Method of Transcutaneously Stimulating the Tibial Nerve for the Treatment of Overactive Bladder.
    Ann Biomed Eng 2017 Aug 28. Epub 2017 Aug 28.
    Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada.
    Transcutaneous electrical nerve stimulation (TENS) can be used to electrically stimulate the tibial nerve for the purpose of treating overactive bladder. Although clinical benefits can be achieved, the overall therapeutic efficacy of TENS is limited. Inconsistent activation of the intended neural target and co-activation of cutaneous sensory fibers are considered key limiting factors. Read More

    An Approach to Integrating Health Disparities within Undergraduate Biomedical Engineering Education.
    Ann Biomed Eng 2017 Aug 28. Epub 2017 Aug 28.
    Department of Biology, Director of Memorial Sloan Kettering (MSK) Partnership, The City College of New York (CCNY), New York, USA.
    Health disparities are preventable differences in the incidence, prevalence and burden of disease among communities targeted by gender, geographic location, ethnicity and/or socio-economic status. While biomedical research has identified partial origin(s) of divergent burden and impact of disease, the innovation needed to eradicate health disparities in the United States requires unique engagement from biomedical engineers. Increasing awareness of the prevalence and consequences of health disparities is particularly attractive to today's undergraduates, who have undauntedly challenged paradigms believed to foster inequality. Read More

    The Feasibility of Enhancing Susceptibility of Glioblastoma Cells to IRE Using a Calcium Adjuvant.
    Ann Biomed Eng 2017 Aug 28. Epub 2017 Aug 28.
    Department of Mechanical Engineering, Virginia Tech, Goodwin Hall, 635 Prices Fork Road - MC 0238, Blacksburg, VA, 24061, USA.
    Irreversible electroporation (IRE) is a cellular ablation method used to treat a variety of cancers. IRE works by exposing tissues to pulsed electric fields which cause cell membrane disruption. Cells exposed to lower energies become temporarily permeable while greater energy exposure results in cell death. Read More

    Non Invasive Blood Flow Features Estimation in Cerebral Arteries from Uncertain Medical Data.
    Ann Biomed Eng 2017 Aug 22. Epub 2017 Aug 22.
    Institut Montpelliérain Alexander Grothendieck (IMAG), Université de Montpellier, CC051, 34095, Montpellier, France.
    A methodology for non-invasive estimation of the pressure in internal carotid arteries is proposed. It uses data assimilation and Ensemble Kalman filters in order to identify unknown parameters in a mathematical description of the cerebral network. The approach uses patient specific blood flow rates extracted from Magnetic Resonance Angiography and Magnetic Resonance Imaging. Read More

    Label-Free Sensing and Classification of Old Stored Blood.
    Ann Biomed Eng 2017 Aug 18. Epub 2017 Aug 18.
    Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Pohang, 790-784, Republic of Korea.
    Transfusion is crucial in surgical operation and anemia treatment. However, several hemorheological properties of blood are adversely altered during blood storage. After transfusion, these adverse alterations are related with decrease of oxygen and ion transport in blood circulation, which increase the mortality of transfused patients. Read More

    Image-Guided Surgical Robotic System for Percutaneous Reduction of Joint Fractures.
    Ann Biomed Eng 2017 Aug 16. Epub 2017 Aug 16.
    Bristol Robotics Laboratory, University of the West of England, Coldharbour Lane, Bristol, BS161QY, UK.
    Complex joint fractures often require an open surgical procedure, which is associated with extensive soft tissue damages and longer hospitalization and rehabilitation time. Percutaneous techniques can potentially mitigate these risks but their application to joint fractures is limited by the current sub-optimal 2D intra-operative imaging (fluoroscopy) and by the high forces involved in the fragment manipulation (due to the presence of soft tissue, e.g. Read More

    Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.
    Ann Biomed Eng 2017 Aug 15. Epub 2017 Aug 15.
    Division of Cardiology, Cincinnati Children's Hospital Medical Center, 240 Albert Sabin Way, MLC 7020, Cincinnati, OH, 45229, USA.
    Aortic valve (AV) disease involves stiffening of the AV cusp with progression characterized by inflammation, fibrosis, and calcification. Here, we examine the relationship between biomechanical valve function and proteomic changes before and after the development of AV pathology in the Emilin1-/- mouse model of latent AV disease. Biomechanical studies were performed to quantify tissue stiffness at the macro (micropipette) and micro (atomic force microscopy (AFM)) levels. Read More

    A Novel Approach to Utilize Icariin as Icariin-Derived ECM on Small Intestinal Submucosa Scaffold for Bone Repair.
    Ann Biomed Eng 2017 Aug 15. Epub 2017 Aug 15.
    Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, 818 Fenghua Road, Ningbo, 315211, Zhejiang, People's Republic of China.
    Icariin (Ic) has been demonstrated as a potent osteoinductive compound for bone tissue engineering. However, toxic side effects of the drug and poor biocompatibility of drug delivery systems (DDSs) still limit its application for bone repair in the clinic. To overcome these disadvantages and utilize the osteoinductivity of Ic, we developed a novel method to utilize Ic as an Ic-derived osteoinductive extracellular matrix (ECM) on small intestinal submucosa (SIS) (Ic-ECM-SIS). Read More

    A Wireless Pressure Sensor for Continuous Monitoring of Intraocular Pressure in Conscious Animals.
    Ann Biomed Eng 2017 Aug 15. Epub 2017 Aug 15.
    Department of Chemical and Biomedical Engineering, University of South Florida, 4202 E Fowler Ave, Tampa, FL, 33620, USA.
    An important aspect of eye health in humans and animal models of human diseases is intraocular pressure (IOP). IOP is typically measured by hand with a tonometer, so data are sparse and sporadic and round-the-clock variations are not well characterized. Here we present a novel system for continuous wireless IOP and temperature measurement in small animals. Read More


    Detergent-Based Decellularization of Bovine Carotid Arteries for Vascular Tissue Engineering.
    Ann Biomed Eng 2017 Aug 7. Epub 2017 Aug 7.
    Auto Tissue Berlin GmbH, Goerzallee 305D, 14167, Berlin, Germany.
    Vascular diseases are an increasing health issue, and common alloplastic, allogenic or autologous vascular grafts show frequent complications. The aim of this study is to develop an acellular, xenogenic bypass-graft from a bovine carotid artery (BAC) using detergent-based protocols. We compared decellularization with sodium desoxycholate (DOA), 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate (Chaps), sodium dodecyl sulfate (SDS), and Triton X100 and improved suitable methods by variation of concentration, buffer system, incubation time, temperature, rinsing, and flow rate. Read More

    Interpreting Musculoskeletal Models and Dynamic Simulations: Causes and Effects of Differences Between Models.
    Ann Biomed Eng 2017 Aug 4. Epub 2017 Aug 4.
    E305 Scott Laboratory, Department of Mechanical and Aerospace Engineering, The Ohio State University, 201 W 19th Ave, Columbus, OH, 43210-1142, USA.
    With more than 29,000 OpenSim users, several musculoskeletal models with varying levels of complexity are available to study human gait. However, how different model parameters affect estimated joint and muscle function between models is not fully understood. The purpose of this study is to determine the effects of four OpenSim models (Gait2392, Lower Limb Model 2010, Full-Body OpenSim Model, and Full Body Model 2016) on gait mechanics and estimates of muscle forces and activations. Read More

    Effect of Chestbands on the Global and Local Response of the Human Thorax to Frontal Impact.
    Ann Biomed Eng 2017 Aug 2. Epub 2017 Aug 2.
    Injury Biomechanics Research Center, The Ohio State University, 2063 Graves Hall, 333 W. 10th Ave., Columbus, OH, 43210, USA.
    The purpose of this study was to examine the effects of chestbands on both global and local thoracic response. A total of twenty-two frontal impacts were imposed on two post-mortem human surrogates, using a 23 kg pneumatic impactor. Impacts were at speeds of 0. Read More

    Fluorinated Methacrylamide Chitosan Hydrogels Enhance Cellular Wound Healing Processes.
    Ann Biomed Eng 2017 Aug 1. Epub 2017 Aug 1.
    Department of Chemical and Biomolecular Engineering, University of Akron, 200 East Buchtel Common, Akron, OH, 44325-3906, USA.
    Low availability of oxygen can lead to stalled wound healing processes and chronic wounds. To address local hypoxia and to better understand direct cellular benefits, a perfluorocarbon conjugated chitosan (MACF) hydrogel that delivers oxygen was created and applied for the first time to in vitro cultures of human dermal fibroblasts and human epidermal keratinocytes under both normoxic (21% O2) and hypoxic (1% O2) environments. Results revealed that local application of MACF provided 233. Read More

    The Quantitative Structural and Compositional Analyses of Degenerating Intervertebral Discs Using Magnetic Resonance Imaging and Contrast-Enhanced Micro-Computed Tomography.
    Ann Biomed Eng 2017 Jul 25. Epub 2017 Jul 25.
    Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
    The intervertebral disc (IVD) is susceptible to degenerative changes that are associated with low back pain. Murine models are often used to investigate the mechanistic changes in the development, aging, and diseased states of the IVD, yet the detection of early degenerative changes in structure is challenging because of the minute size of the murine IVDs. Histology is the gold standard for examining the IVD structure, but it is susceptible to sectioning artifacts, spatial biases, and requires the destructive preparation of the sample. Read More

    Cell Mechanosensors and the Possibilities of Using Magnetic Nanoparticles to Study Them and to Modify Cell Fate.
    Ann Biomed Eng 2017 Jul 25. Epub 2017 Jul 25.
    The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, 200120, China.
    The use of magnetic nanoparticles (MNPs) is a promising technique for future advances in biomedical applications. This idea is supported by the availability of MNPs that can target specific cell components, the variety of shapes of MNPs and the possibility of finely controlling the applied magnetic forces. To examine this opportunity, here we review the current developments in the use of MNPs to mechanically stimulate cells and, specifically, the cell mechanotransduction systems. Read More

    Organ Dynamics and Fluid Dynamics of the HH25 Chick Embryonic Cardiac Ventricle as Revealed by a Novel 4D High-Frequency Ultrasound Imaging Technique and Computational Flow Simulations.
    Ann Biomed Eng 2017 Jul 25. Epub 2017 Jul 25.
    Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
    Past literature has provided evidence that a normal mechanical force environment of blood flow may guide normal development while an abnormal environment can lead to congenital malformations, thus warranting further studies on embryonic cardiovascular flow dynamics. In the current study, we developed a non-invasive 4D high-frequency ultrasound technique, and use it to analyze cardiovascular organ dynamics and flow dynamics. Three chick embryos at stage HH25 were scanned with high frequency ultrasound in cine-B-mode at multiple planes spaced at 0. Read More

    Methodology to Produce Specimen-Specific Models of Vertebrae: Application to Different Species.
    Ann Biomed Eng 2017 Jul 25. Epub 2017 Jul 25.
    School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds, LS2 9JT, UK.
    Image-based continuum-level finite element models have been used for bones to evaluate fracture risk and the biomechanical effects of diseases and therapies, capturing both the geometry and tissue mechanical properties. Although models of vertebrae of various species have been developed, an inter-species comparison has not yet been investigated. The purpose of this study was to derive species-specific modelling methods and compare the accuracy of image-based finite element models of vertebrae across species. Read More

    Quantification of Hand Motor Symptoms in Parkinson's Disease: A Proof-of-Principle Study Using Inertial and Force Sensors.
    Ann Biomed Eng 2017 Jul 19. Epub 2017 Jul 19.
    Biomedical Signals and Systems Group, MIRA Research Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
    This proof-of-principle study describes the methodology and explores and demonstrates the applicability of a system, existing of miniature inertial sensors on the hand and a separate force sensor, to objectively quantify hand motor symptoms in patients with Parkinson's disease (PD) in a clinical setting (off- and on-medication condition). Four PD patients were measured in off- and on- dopaminergic medication condition. Finger tapping, rapid hand opening/closing, hand pro/supination, tremor during rest, mental task and kinetic task, and wrist rigidity movements were measured with the system (called the PowerGlove). Read More

    A Comprehensive Characterization of Parameters Affecting High-Frequency Irreversible Electroporation Lesions.
    Ann Biomed Eng 2017 Jul 18. Epub 2017 Jul 18.
    Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
    Several focal therapies are being investigated clinically to treat tumors in which surgery is contraindicated. Many of these ablation techniques, such as radiofrequency ablation and microwave ablation, rely on thermal damage mechanisms which can put critical nerves or vasculature at risk. Irreversible electroporation (IRE) is a minimally invasive, non-thermal technique to destroy tumors. Read More

    Modelling of Lesions Associated with Functional Mitral Regurgitation in an Ex Vivo Platform.
    Ann Biomed Eng 2017 Jul 18. Epub 2017 Jul 18.
    Department of Electronics, Information and Bioengineering, Politecnico di Milano, Via Golgi 39, 20133, Milan, Italy.
    Functional mitral regurgitation (FMR) is a complex pathology involving valvular and subvalvular structures reconfiguration, and its treatment is considered challenging. There is a lack of experimental models allowing for reliable preclinical FMR treatments' evaluation in a realistic setting. A novel approach to simulate FMR was developed and incorporated into an ex vivo passive beating heart platform. Read More

    Peristaltic-Like Motion of the Human Fetal Right Ventricle and its Effects on Fluid Dynamics and Energy Dynamics.
    Ann Biomed Eng 2017 Jul 18. Epub 2017 Jul 18.
    Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
    In both adult human and canine, the cardiac right ventricle (RV) is known to exhibit a peristaltic-like motion, where RV sinus (inflow region) contracts first and the infundibulum (outflow region) later, in a wave-like contraction motion. The delay in contraction between the sinus and infundibulum averaged at 15% of the cardiac cycle and was estimated to produce an intra-ventricular pressure difference of 15 mmHg. However, whether such a contractile motion occurs in human fetuses as well, its effects on hemodynamics remains unknown, and are the subject of the current study. Read More

    Erratum to: Development of an Electromechanical Grade to Assess Human Knee Articular Cartilage Quality.
    Ann Biomed Eng 2017 Jul 18. Epub 2017 Jul 18.
    Department of Chemical Engineering and Institute of Biomedical Engineering, Polytechnique Montreal, P.O. Box 6079, Station Centre-Ville, 2900 Boul. Edouard-Montpetit, Montreal, QC, H3C 3A7, Canada.

    Performance Evaluation of a Pre-computed Brain Response Atlas in Dummy Head Impacts.
    Ann Biomed Eng 2017 Jul 14. Epub 2017 Jul 14.
    Department of Biomedical Engineering, Worcester Polytechnic Institute, 60 Prescott Street, Worcester, MA, 01506, USA.
    A pre-computed brain response atlas (pcBRA) may have the potential to accelerate the investigation of the biomechanical mechanisms of traumatic brain injury on a large-scale. In this study, we further enhance the technique and evaluate its performance using six degree-of-freedom angular velocity profiles from dummy head impacts. Using the pcBRA to simplify profiles into acceleration-only shapes, sufficiently accurate strain estimates were obtained for impacts with a major dominating velocity peak. Read More

    Pulse Rate and Transit Time Analysis to Predict Hypotension Events After Spinal Anesthesia During Programmed Cesarean Labor.
    Ann Biomed Eng 2017 Jul 11. Epub 2017 Jul 11.
    BSICoS Group, Aragón Institute of Engineering Research (I3A), IIS Aragón, University of Zaragoza, Mariano Esquillor SN, Edif. I+D+I, Lab 4.0.05, 50018, Saragossa, Spain.
    Prophylactic treatment has been proved to reduce hypotension incidence after spinal anesthesia during cesarean labor. However, the use of pharmacological prophylaxis could carry out undesirable side-effects on mother and fetus. Thus, the prediction of hypotension becomes an important challenge. Read More

    The Identification and Tracking of Uterine Contractions Using Template Based Cross-Correlation.
    Ann Biomed Eng 2017 Jun 28. Epub 2017 Jun 28.
    RPA Women and Babies, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW, 2050, Australia.
    The purpose of this paper is to outline a novel method of using template based cross-correlation to identify and track uterine contractions during labour. A purpose built six-channel Electromyography (EMG) device was used to collect data from consenting women during labour and birth. A range of templates were constructed for the purpose of identifying and tracking uterine activity when cross-correlated with the EMG signal. Read More

    Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation.
    Ann Biomed Eng 2017 Jun 26. Epub 2017 Jun 26.
    Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz Philadelphia VA Medical Center, 3900 University & Woodland Avenue, Philadelphia, PA, 19104, USA.
    While delayed delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with improved tendon healing, early delivery has been associated with impaired healing. Therefore, NSAID use is appropriate only if the dose, timing, and mode of delivery relieves pain but does not impede tissue repair. Because delivery parameters can be controlled using drug-eluting nanofibrous scaffolds, our objective was to develop a scaffold for local controlled release of ibuprofen (IBP), and characterize the release profile and degradation both in vitro and in vivo. Read More

    Development of an Electromechanical Grade to Assess Human Knee Articular Cartilage Quality.
    Ann Biomed Eng 2017 Jun 26. Epub 2017 Jun 26.
    Department of Chemical Engineering and Institute of Biomedical Engineering, Polytechnique Montreal, P.O. Box 6079, Station Centre-Ville, 2900 Boul. Edouard-Montpetit, Montreal, QC, H3C 3A7, Canada.
    Quantitative assessments of articular cartilage function are needed to aid clinical decision making. Our objectives were to develop a new electromechanical grade to assess quantitatively cartilage quality and test its reliability. Electromechanical properties were measured using a hand-held electromechanical probe on 200 human articular surfaces from cadaveric donors and osteoarthritic patients. Read More

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