5,488 results match your criteria Annals of biomedical engineering[Journal]


A Distributed Lumped Parameter Model of Blood Flow.

Ann Biomed Eng 2020 Jul 1. Epub 2020 Jul 1.

Mechanical Engineering, University of California, Berkeley, CA, 94720, USA.

We propose a distributed lumped parameter (DLP) modeling framework to efficiently compute blood flow and pressure in vascular domains. This is achieved by developing analytical expressions describing expected energy losses along vascular segments, including from viscous dissipation, unsteadiness, flow separation, vessel curvature and vessel bifurcations. We apply this methodology to solve for unsteady blood flow and pressure in a variety of complex 3D image-based vascular geometries, which are typically approached using computational fluid dynamics (CFD) simulations. Read More

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http://dx.doi.org/10.1007/s10439-020-02545-6DOI Listing

Enhanced In-Silico Polyethylene Wear Simulation of Total Knee Replacements During Daily Activities.

Ann Biomed Eng 2020 Jun 30. Epub 2020 Jun 30.

Department of Mechanical Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

A computational wear simulator is an efficient tool for evaluating the wear of artificial knee joints. The classical Archard's wear law-based simulator has questionable accuracy and is focused on walking. In this study, an in silico polyethylene wear simulation of total knee replacements was developed considering the various highly demanding daily activities. Read More

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http://dx.doi.org/10.1007/s10439-020-02555-4DOI Listing

A Review on Advances in Intra-operative Imaging for Surgery and Therapy: Imagining the Operating Room of the Future.

Ann Biomed Eng 2020 Jun 29. Epub 2020 Jun 29.

Department of Experimental and Clinical Medicine, Universitá della Magna Graecia, Catanzaro, Italy.

With the advent of Minimally Invasive Surgery (MIS), intra-operative imaging has become crucial for surgery and therapy guidance, allowing to partially compensate for the lack of information typical of MIS. This paper reviews the advancements in both classical (i.e. Read More

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http://dx.doi.org/10.1007/s10439-020-02553-6DOI Listing

Questioning the Value of the Graduate Record Examinations (GRE) in PhD Admissions in Biomedical Engineering.

Ann Biomed Eng 2020 Jun 22. Epub 2020 Jun 22.

Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA.

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http://dx.doi.org/10.1007/s10439-020-02552-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307944PMC

The Application of Digital Volume Correlation (DVC) to Evaluate Strain Predictions Generated by Finite Element Models of the Osteoarthritic Humeral Head.

Ann Biomed Eng 2020 Jun 22. Epub 2020 Jun 22.

Department of Mechanical and Materials Engineering, Western University, London, ON, Canada.

Continuum-level finite element models (FEMs) of the humerus offer the ability to evaluate joint replacement designs preclinically; however, experimental validation of these models is critical to ensure accuracy. The objective of the current study was to quantify experimental full-field strain magnitudes within osteoarthritic (OA) humeral heads by combining mechanical loading with volumetric microCT imaging and digital volume correlation (DVC). The experimental data was used to evaluate the accuracy of corresponding FEMs. Read More

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http://dx.doi.org/10.1007/s10439-020-02549-2DOI Listing

Head Impact Burden Differs Between Seasons in Youth and High School US Football Players.

Ann Biomed Eng 2020 Jun 18. Epub 2020 Jun 18.

Pediatric Neurology, Nationwide Children's Hospital and The Ohio State University, 700 Children's Drive, Columbus, OH, 43205, USA.

Retrospective estimates of head impact burden in contact sports are often used in studies assessing for correlation of head impact exposure with neurocognitive outcomes later in life. These estimations assume a consistent impact burden from year to year. We monitored head impacts in youth tackle football players in the 6th-8th grades and high school varsity players using helmet-based sensors during two consecutive seasons. Read More

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http://dx.doi.org/10.1007/s10439-020-02548-3DOI Listing

Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells.

Ann Biomed Eng 2020 Jun 15. Epub 2020 Jun 15.

Faculty of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa, 3200003, Israel.

We provide an innovative, bioengineering, mechanobiology-based approach to rapidly (2-h) establish the in vivo metastatic likelihood of patient tumor-samples, where results are in direct agreement with clinical histopathology and patient outcomes. Cancer-related mortality is mostly due to local recurrence or to metastatic disease, thus early prediction of tumor-cell-fate may critically affect treatment protocols and survival rates. Metastasis and recurrence risks are currently predicted by lymph-node status, tumor size, histopathology and genetic testing, however, these are not infallible and results may require days/weeks. Read More

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http://dx.doi.org/10.1007/s10439-020-02547-4DOI Listing

Development and Evaluation of CT-to-3D Ultrasound Image Registration Algorithm in Vertebral Phantoms for Spine Surgery.

Ann Biomed Eng 2020 Jun 12. Epub 2020 Jun 12.

Department of Biomedical Engineering, University of Alberta, 1098 Research Transition Facility, 8308-114 Street, Edmonton, AB, T6G 2V2, Canada.

Posterior spinal fusion surgery requires careful insertion of screws into the spine to avoid neurologic injury. While current systems use CT-scans, three-dimensional ultrasound (3DUS) could provide guidance by reconstructing the vertebral surface, and then registering a pre-operative vertebral model to that surface for localization. The aim of this study was to evaluate the accuracy and processing time of a custom CT-3DUS registration algorithm. Read More

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http://dx.doi.org/10.1007/s10439-020-02546-5DOI Listing

In Vitro Assessment of Flow Variability in an Intracranial Aneurysm Model Using 4D Flow MRI and Tomographic PIV.

Ann Biomed Eng 2020 Jun 10. Epub 2020 Jun 10.

Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, USA.

Aneurysm rupture has been suggested to be related to aneurysm geometry, morphology, and complex flow activity; therefore, understanding aneurysm-specific hemodynamics is crucial. 4D Flow MRI has been shown to be a feasible tool for assessing hemodynamics in intracranial aneurysms with high spatial resolution. However, it requires averaging over multiple heartbeats and cannot account for cycle-to-cycle hemodynamics variations. Read More

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http://dx.doi.org/10.1007/s10439-020-02543-8DOI Listing

A Chemo-poroelastic Analysis of Mechanically Induced Fluid and Solute Transport in an Osteonal Cortical Bone.

Ann Biomed Eng 2020 Jun 8. Epub 2020 Jun 8.

Department of Biosystems and Agricultural Engineering, University of Kentucky, Lexington, KY, 40546, USA.

It is well known that transport of nutrients and wastes as solute in bone fluid plays an important role in bone remodeling and damage healing. This work presents a chemo-poroelastic model for fluid and solute transport in the lacunar-canalicular network of an osteonal cortical bone under cyclic axial mechanical loading or vascular pressure. Analytical solutions are obtained for the pore fluid pressure, and fluid and solute velocities. Read More

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http://dx.doi.org/10.1007/s10439-020-02544-7DOI Listing

Effectiveness of low-intensity pulsed ultrasound on osteoarthritis of the temporomandibular joint: A review.

Ann Biomed Eng 2020 Jun 8. Epub 2020 Jun 8.

Department of Oral Histology and Tissue Engineering, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

Loading is indispensable for the growth, development, and maintenance of joint tissues, including mandibular condylar cartilage, but excessive loading or reduced host adaptive capacity can considerably damage the temporomandibular joint (TMJ), leading to temporomandibular joint osteoarthritis (TMJ-OA). TMJ-OA, associated with other pathological conditions and aging processes, is a highly degenerative disease affecting the articular cartilage. Many treatment modalities for TMJ-OA have been developed. Read More

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http://dx.doi.org/10.1007/s10439-020-02540-xDOI Listing

A Wearable Augmented Reality Navigation System for Surgical Telementoring Based on Microsoft HoloLens.

Ann Biomed Eng 2020 Jun 5. Epub 2020 Jun 5.

Department of Precision Machinery and Instrumentation, University of Science and Technology of China, Hefei, Anhui, China.

This paper reports a new type of augmented reality (AR) system that integrates a Microsoft HoloLens device with a three-dimensional (3D) point tracking module for medical training and telementored surgery. In this system, a stereo camera is used to track the 3D position of a scalpel and transfer its coordinates wirelessly to a HoloLens device. In the scenario of surgical training, a virtual surgical scene with pre-recorded surgical annotations is superimposed with the actual surgical scene so that the surgical trainee is able to operate following virtual instructions. Read More

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http://dx.doi.org/10.1007/s10439-020-02538-5DOI Listing

Stereolithography 3D Bioprinting Method for Fabrication of Human Corneal Stroma Equivalent.

Ann Biomed Eng 2020 Jul 5;48(7):1955-1970. Epub 2020 Jun 5.

School of Engineering, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.

3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print the anatomically similar dome-shaped structure of the human corneal stroma. Read More

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http://dx.doi.org/10.1007/s10439-020-02537-6DOI Listing

Tension Strain-Softening and Compression Strain-Stiffening Behavior of Brain White Matter.

Ann Biomed Eng 2020 Jun 3. Epub 2020 Jun 3.

Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.

Brain, the most important component of the central nervous system (CNS), is a soft tissue with a complex structure. Understanding the role of brain tissue microstructure in mechanical properties is essential to have a more profound knowledge of how brain development, disease, and injury occur. While many studies have investigated the mechanical behavior of brain tissue under various loading conditions, there has not been a clear explanation for variation reported for material properties of brain tissue. Read More

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http://dx.doi.org/10.1007/s10439-020-02541-wDOI Listing

Ultra-High-Frame-Rate Ultrasound Monitoring of Muscle Contractility Changes Due to Neuromuscular Electrical Stimulation.

Ann Biomed Eng 2020 Jun 1. Epub 2020 Jun 1.

Department of Mechanical Engineering and Materials Science, University of Pittsburgh School of Engineering, Pittsburgh, PA, 15261, USA.

The quick onset of muscle fatigue is a critical issue when applying neuromuscular electrical stimulation (NMES) to generate muscle contractions for functional limb movements, which were lost/impaired due to a neurological disorder or an injury. For in situ assessment of the effect of NMES-induced muscle fatigue, a novel noninvasive sensor modality that can quantify the degraded contractility of a targeted muscle is required. In this study, instantaneous strain maps of a contracting muscle were derived from ultra-high-frame-rate (2 kHz) ultrasound images to quantify the contractility. Read More

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http://dx.doi.org/10.1007/s10439-020-02536-7DOI Listing

Computational Tools for the Reliability Assessment and the Engineering Design of Procedures and Devices in Bariatric Surgery.

Ann Biomed Eng 2020 May 29. Epub 2020 May 29.

Centre for Mechanics of Biological Materials, University of Padova, Padua, Italy.

Obesity is one of the main health concerns worldwide. Bariatric Surgery (BS) is the gold standard treatment for severe obesity. Nevertheless, unsatisfactory weight loss and complications can occur. Read More

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http://dx.doi.org/10.1007/s10439-020-02542-9DOI Listing

A Novel Multiplex Based Platform for Osteoarthritis Drug Candidate Evaluation.

Ann Biomed Eng 2020 May 29. Epub 2020 May 29.

Department of Mechanical Engineering, National Technical University of Athens, Heroon Polytechniou 9, 15780, Zografou, Greece.

Osteoarthritis (OA) is characterized by irreversible cartilage degradation with very limited therapeutic interventions. Drug candidates targeted at prototypic players had limited success until now and systems based approaches might be necessary. Consequently, drug evaluation platforms should consider the biological complexity looking beyond well-known contributors of OA. Read More

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http://dx.doi.org/10.1007/s10439-020-02539-4DOI Listing

Eyes in Ears: A Miniature Steerable Digital Endoscope for Trans-Nasal Diagnosis of Middle Ear Disease.

Ann Biomed Eng 2020 May 26. Epub 2020 May 26.

Vanderbilt University Engineering Department, Nashville, TN, USA.

The aim of this work is to design, fabricate and experimentally validate a miniature steerable digital endoscope that can provide comprehensive, high-resolution imaging of the middle ear using a trans-nasal approach. The motivation for this work comes from the high incidence of middle ear diseases, and the current reliance on invasive surgery to diagnose and survey these diseases which typically consists of the eardrum being lifted surgically to directly visualize the middle ear using a trans-canal approach. To enable less-invasive diagnosis and surveillance of middle ear disease, we propose an endoscope that is small enough to pass into the middle ear through the Eustachian tube, with a steerable tip that carries a 1 Megapixel image sensor and fiber-optic illumination to provide high-resolution visualization of critical middle ear structures. Read More

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http://dx.doi.org/10.1007/s10439-020-02518-9DOI Listing

Constructing a Human Atrial Fibre Atlas.

Ann Biomed Eng 2020 May 26. Epub 2020 May 26.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy measurements are not currently available, and consequently assigning fibre fields to atrial models is challenging. We aimed to construct an atrial fibre atlas from a high-resolution DTMRI dataset that optimally reproduces electrophysiology simulation predictions corresponding to patient-specific fibre fields, and to develop a methodology for automatically assigning fibres to patient-specific anatomies. Read More

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http://dx.doi.org/10.1007/s10439-020-02525-wDOI Listing

Thermal Effects on Fluid Mixing in the Eye.

Ann Biomed Eng 2020 May 26. Epub 2020 May 26.

Department of Medical Engineering, California Institute of Technology, 1200 E California Blvd, MC 105-50, Pasadena, CA, 91125, USA.

Age-related macular degeneration (AMD) is the leading cause of central vision loss in the developed world. Wet AMD can be managed through serial intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents. However, sometimes the treatment is ineffective. Read More

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http://dx.doi.org/10.1007/s10439-020-02534-9DOI Listing

Improving Freezing Protocols and Organotypic Culture: A Histological Study on Rat Prepubertal Testicular Tissue.

Ann Biomed Eng 2020 May 21. Epub 2020 May 21.

Department of Reproductive Biology-CECOS, Rouen University Hospital, EA 4308 "Gametogenesis and Gamete Quality", UNIROUEN, Normandie Univ, 22 Boulevard Gambetta, 76000, Rouen, France.

Testicular tissue freezing before gonadotoxic treatments allows the preservation of fertility for children suffering from cancer. Recently, the testis organ culture method was presented as a relevant method to restore the fertility of these patients. However, the yield of spermatozoa production is low in the mouse model and no gamete has been obtained in vitro in the rat model. Read More

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http://dx.doi.org/10.1007/s10439-020-02535-8DOI Listing

Influence of Patient-Specific Characteristics on Transcatheter Heart Valve Neo-Sinus Flow: An In Silico Study.

Ann Biomed Eng 2020 May 15. Epub 2020 May 15.

The Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

Thrombosis in post-transcatheter aortic valve replacement (TAVR) patients has been correlated with flow stasis in the neo-sinus. This study investigated the effect of the post-TAVR geometry on flow stasis. Computed tomography angiography of 155 patients who underwent TAVR using a SAPIEN 3 were used to identify patients with and without thrombosis, and quantify thrombus volumes. Read More

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http://dx.doi.org/10.1007/s10439-020-02532-xDOI Listing

Electro-Thermal Therapy Algorithms and Active Internal Electrode Cooling Reduce Thermal Injury in High Frequency Pulsed Electric Field Cancer Therapies.

Ann Biomed Eng 2020 May 15. Epub 2020 May 15.

UNC - NCSU Joint Department of Biomedical Engineering, Raleigh, NC, USA.

Thermal tissue injury is an unintended consequence in current irreversible electroporation treatments due to the induction of Joule heating during the delivery of high voltage pulsed electric fields. In this study active temperature control measures including internal electrode cooling and dynamic energy delivery were investigated as a process for mitigating thermal injury during treatment. Ex vivo liver was used to examine the extent of thermal injury induced by 5000 V treatments with delivery rates up to five times faster than current clinical practice. Read More

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http://dx.doi.org/10.1007/s10439-020-02524-xDOI Listing

Temperature Dependence of High Frequency Irreversible Electroporation Evaluated in a 3D Tumor Model.

Ann Biomed Eng 2020 May 14. Epub 2020 May 14.

UNC/NCSU Joint Department of Biomedical Engineering, 911 Oval Drive, Raleigh, NC, 27606, USA.

Electroporation is a bioelectric phenomenon used to deliver target molecules into cells in vitro and irreversible electroporation (IRE) is an emerging cancer therapy used to treat inoperable tumors in situ. These phenomena are generally considered to be non-thermal in nature. In this study, a 3D tumor model was used to investigate the correlation between temperature and the effectiveness of standard clinical IRE and high frequency (H-FIRE) protocols. Read More

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http://dx.doi.org/10.1007/s10439-019-02423-wDOI Listing

Equestrian Helmet Standards: Do They Represent Real-World Accident Conditions?

Ann Biomed Eng 2020 May 12. Epub 2020 May 12.

School of Mechanical & Materials Engineering, University College Dublin, Belfield, Dublin 4, Ireland.

The use of helmets in equestrian sports has reduced the occurrence of traumatic brain injuries although, despite improvements to helmets, concussion remains a common injury. Currently, equestrian helmets are designed to pass certification standards involving a linear drop test to a rigid surface, while most concussions in equestrian sports result from oblique impacts to a compliant surface. The purpose of this study was to: (1) Compare the head kinematics and brain tissue response of the current equestrian helmet standard (EN1) and proposed standard EN13087-11 (EN2) to those associated with reconstructions of real-world equestrian concussion accidents. Read More

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http://dx.doi.org/10.1007/s10439-020-02531-yDOI Listing

ABME Special Issue Editorial: Engineering Cell Behavior.

Authors:
Debra Auguste

Ann Biomed Eng 2020 Jul;48(7):1863

Chemical Engineering, Northeastern University, 360 Huntington Avenue, Interdisciplinary Science and Engineering Center 327, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s10439-020-02530-zDOI Listing

Efficiently Simulating an Endograft Deployment: A Methodology for Detailed CFD Analyses.

Ann Biomed Eng 2020 May 11. Epub 2020 May 11.

Department of Mechanical and Aerospace Engineering, University of Strathclyde, 75 Montrose Street, Glasgow, G1 1XJ, UK.

Numerical models of endografts for the simulation of endovascular aneurysm repair are increasingly important in the improvement of device designs and patient outcomes. Nevertheless, current finite element analysis (FEA) models of complete endograft devices come at a high computational cost, requiring days of runtime, therefore restricting their applicability. In the current study, an efficient FEA model of the Anaconda™ endograft (Terumo Aortic, UK) was developed, able to yield results in just over 4 h, an order of magnitude less than similar models found in the literature. Read More

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http://dx.doi.org/10.1007/s10439-020-02519-8DOI Listing

Elastic Modulus of Woven Bone: Correlation with Evolution of Porosity and X-ray Greyscale.

Ann Biomed Eng 2020 May 9. Epub 2020 May 9.

Department of Mechanical and Manufacturing Engineering, University of Seville, Seville, Spain.

The woven bone created during the healing of bone regeneration processes is characterized as being extremely inhomogeneous and having a variable stiffness that increases with time. Therefore, it is important to study how the mechanical properties of woven bone are dependent on its microarchitecture and especially on its porosity and mineral content. The porosity and the x-ray greyscale of specimens taken from bone transport studies in sheep were assessed by means of ex vivo imaging. Read More

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http://dx.doi.org/10.1007/s10439-020-02529-6DOI Listing

Prediction of Knee Kinematics at the Time of Noncontact Anterior Cruciate Ligament Injuries Based on the Bone Bruises.

Ann Biomed Eng 2020 May 7. Epub 2020 May 7.

Institute of Sports Medicine, Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries, Beijing, 100191, China.

Biomechanical risk factors associated with the alignment and position of the knee for anterior cruciate ligament (ACL) injury are still not conclusive. As bone bruises identified on magnetic resonance imaging (MRI) following acute ACL injury could represent the impact footprint at the time of injury. To improve understanding of the ACL injury mechanism, we aimed to determine the knee kinematics during ACL injury based on the bone bruises. Read More

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http://dx.doi.org/10.1007/s10439-020-02523-yDOI Listing

The Role of Feedback Control Design in Developing Anemia Management Protocols.

Ann Biomed Eng 2020 May 7. Epub 2020 May 7.

Mathematics and Statistics Department, University of Massachusetts, Amherst, MA, 01003, USA.

The optimal use of erythropoiesis stimulating agents to treat anemia of end-stage renal disease remains difficult due to reported associations with adverse events. A patient's hemoglobin response to these agents cannot be accurately described using population-level models due to many individual factors including chronic inflammation, red blood cell lifespan, and acute blood loss. As a consequence, it is generally understood that current one-size-fits-all anemia management protocols result in suboptimal outcomes. Read More

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http://dx.doi.org/10.1007/s10439-020-02520-1DOI Listing

Computational Modelling of the Bioheat Transfer Process in Human Skin Subjected to Direct Heating and/or Cooling Sources: A Systematic Review.

Ann Biomed Eng 2020 Jun 6;48(6):1616-1639. Epub 2020 May 6.

Center for MicroElectroMechanical Systems (CMEMS-UMINHO), University of Minho, Azurém Campus, 4800-058, Guimarães, Portugal.

The purpose of this systematic review is to analyze characteristics and methodologies utilized in bioheat transfer models of human skin to provide state-of-the-art knowledge on the topic. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. PubMed, EMBASE and Web of Science databases were searched up to May 30th, 2019 for bioheat transfer models focusing on direct contact between skin and temperature (heat and/or cold) source. Read More

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http://dx.doi.org/10.1007/s10439-020-02515-yDOI Listing

Nanoparticle-Mediated TGF-β Release from Microribbon-Based Hydrogels Accelerates Stem Cell-Based Cartilage Formation In Vivo.

Ann Biomed Eng 2020 Jul 6;48(7):1971-1981. Epub 2020 May 6.

Departments of Bioengineering and Orthopedic Surgery, Stanford University Schools of Engineering and Medicine, 300 Pasteur Drive, Edwards R105, Stanford, CA, 94305, USA.

Conventional nanoporous hydrogels often lead to slow cartilage deposition by MSCs in 3D due to physical constraints and requirement for degradation. Our group has recently reported macroporous gelatin microribbon (μRB) hydrogels, which substantially accelerate MSC-based cartilage formation in vitro compared to conventional gelatin hydrogels. To facilitate translating the use of μRB-based scaffolds for supporting stem cell-based cartilage regeneration in vivo, there remains a need to develop a customize-designed drug delivery system that can be incorporated into μRB-based scaffolds. Read More

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http://dx.doi.org/10.1007/s10439-020-02522-zDOI Listing

An Instrumented Urethral Catheter with a Distributed Array of Iontronic Force Sensors.

Ann Biomed Eng 2020 May 6. Epub 2020 May 6.

Department of Mechanical Engineering, University of Minnesota, Minneapolis, USA.

This paper develops a novel instrumented urethral catheter with an array of force sensors for measuring the distributed pressure in a human urethra. The catheter and integrated portions of the force sensors are fabricated by the use of 3D printing using a combination of both soft and hard polymer substrates. Other portions of the force sensors consisting of electrodes and electrolytes are fabricated separately and assembled on top of the 3D-printed catheter to create a soft flexible device. Read More

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http://dx.doi.org/10.1007/s10439-020-02528-7DOI Listing

Non-Newtonian Effects on Patient-Specific Modeling of Fontan Hemodynamics.

Ann Biomed Eng 2020 May 5. Epub 2020 May 5.

Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive NW, Atlanta, GA, 30332, USA.

The Fontan procedure is a common palliative surgery for congenital single ventricle patients. In silico and in vitro patient-specific modeling approaches are widely utilized to investigate potential improvements of Fontan hemodynamics that are related to long-term complications. However, there is a lack of consensus regarding the use of non-Newtonian rheology, warranting a systematic investigation. Read More

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http://dx.doi.org/10.1007/s10439-020-02527-8DOI Listing

Plasma Isolation in a Syringe by Conformal Integration of Inertial Microfluidics.

Ann Biomed Eng 2020 May 4. Epub 2020 May 4.

Department of Mechanical Engineering, University of Maryland, College Park, MD, 20742, USA.

A thermoplastic microfluidic substrate is conformally integrated onto the cylindrical barrel of a conventional venipuncture syringe, forming a spiral inertial separation element supporting the isolation of plasma from diluted whole blood. The cylindrical shape of the syringe itself serves to define the flow path required for inertial separation by transforming a linear microchannel to a spiral topology. The hybrid system enables inertial plasma separation by Dean flow focusing within the same syringe used for a patient blood draw, with the seamlessly interconnected microfluidic element operated by automated or manual actuation of the syringe plunger. Read More

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http://dx.doi.org/10.1007/s10439-020-02526-9DOI Listing

Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning.

Ann Biomed Eng 2020 May 4. Epub 2020 May 4.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offer an attractive experimental platform to investigate cardiac diseases and therapeutic outcome. In this study, iPSC-CMs were utilized to study their calcium transient signals and drug effects by means of machine learning, a central part of artificial intelligence. Drug effects were assessed in six iPSC-lines carrying different mutations causing catecholaminergic polymorphic ventricular tachycardia (CPVT), a highly malignant inherited arrhythmogenic disorder. Read More

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http://dx.doi.org/10.1007/s10439-020-02521-0DOI Listing

Stress Measurements on the Articular Cartilage Surface Using Fiber Optic Technology and In-Vivo Gait Kinematics.

Ann Biomed Eng 2020 Apr 27. Epub 2020 Apr 27.

McCaig Institute for Bone & Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada.

It has been hypothesized a change in stress on the cartilage of a joint is a significant factor in the initiation and progression of post-traumatic osteoarthritis. Without a reliable method for measuring stress, this hypothesis has largely gone untested. In this study, a novel, repeatable, and reliable method for measuring stress on the surface of articular cartilage in articular joints is presented. Read More

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http://dx.doi.org/10.1007/s10439-020-02516-xDOI Listing

Optimization of Female Head-Neck Model with Active Reflexive Cervical Muscles in Low Severity Rear Impact Collisions.

Ann Biomed Eng 2020 Apr 24. Epub 2020 Apr 24.

Department of Mechanics and Maritime Sciences, Chalmers University of Technology (Campus Lindholmen), Hörselgången 4, 41296, Gothenburg, Sweden.

ViVA Open Human Body Model (HBM) is an open-source human body model that was developed to fill the gap of currently available models that lacked the average female size. In this study, the head-neck model of ViVA OpenHBM was further developed by adding active muscle controllers for the cervical muscles to represent the human neck muscle reflex system as studies have shown that cervical muscles influence head-neck kinematics during impacts. The muscle controller was calibrated by conducting optimization-based parameter identification of published-volunteer data. Read More

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http://dx.doi.org/10.1007/s10439-020-02512-1DOI Listing

Cerebrovascular Reactivity in Special Operations Forces Combat Soldiers.

Ann Biomed Eng 2020 Jun 23;48(6):1651-1660. Epub 2020 Apr 23.

Matthew Gfeller Sport-Related Traumatic Brain Injury Research Center, Department of Exercise and Sport Science, The University of North Carolina at Chapel Hill, 2207 Stallings-Evans Sports Medicine Center, Campus Box 8700, Chapel Hill, NC, 27599, USA.

The purpose of this study was to investigate how concussion history affects cerebrovascular reactivity (CVR) in Special Operations Forces (SOF) combat soldiers. We studied 104 SOF soldiers [age = 33.5 ± 4. Read More

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http://dx.doi.org/10.1007/s10439-020-02514-zDOI Listing

Altered β-Cell Calcium Dynamics via Electric Field Exposure.

Ann Biomed Eng 2020 Apr 22. Epub 2020 Apr 22.

Department of Bioengineering, University of Texas at Arlington, 500 UTA Blvd., Suite 226, Arlington, TX, 76010, USA.

Electric field stimulation has long been investigated with results supporting its therapeutic potential; however, its effects on insulin secreting cells has yet to be fully elucidated. Herein we explored the effects of physiological direct current (DC) electric field stimulation on the intracellular calcium dynamics of mouse derived βTC-6 insulinoma cells. This electrical stimulation resulted in an elevation in intracellular calcium along with a rise in calcium spiking activity. Read More

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http://dx.doi.org/10.1007/s10439-020-02517-wDOI Listing

Insertion of Small Diameter Radiopaque Tracking Beads into the Anterior Cruciate Ligament Results in Repeatable Strain Measurement Without Affecting the Material Properties.

Ann Biomed Eng 2020 Apr 20. Epub 2020 Apr 20.

Department of Mechanical and Materials Engineering, Lawson Health Sciences Institute, Western University, 1151 Richmond Rd, London, ON, N6A 5B9, Canada.

The characterization of ligamentous soft tissue properties is limited by a lack of measurement methods capable of minimally-invasively quantifying regional strain. Previous implementations of radiographic imaging and tissue-embedded radiopaque markers demonstrated promising regional strain measurements, but found error associated with non-repeatable bead positions within the tissue after load application. No study has investigated the effects of cyclic loading on the strains measured within the tissue. Read More

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http://dx.doi.org/10.1007/s10439-020-02511-2DOI Listing

Enzyme-Mediated Conjugation of Peptides to Silk Fibroin for Facile Hydrogel Functionalization.

Ann Biomed Eng 2020 Jul 20;48(7):1905-1915. Epub 2020 Apr 20.

Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA.

Enzymatic crosslinking of tyrosine is a simple and modular method for adding functional peptides to silk fibroin (SF) hydrogels. Silk fibroin is a naturally derived polymer notable for its robust mechanical properties, biological compatibility, and versatility. Hydrogels fabricated from SF are elastic, optically clear, and have tunable moduli, however, they do not contain native biological epitopes for cell interactions. Read More

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http://dx.doi.org/10.1007/s10439-020-02503-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334058PMC

Perspectives on Bioengineering Clinical Immersion: History, Innovation, and Impact.

Ann Biomed Eng 2020 Apr 20. Epub 2020 Apr 20.

School of Design, University of Illinois at Chicago, Chicago, IL, USA.

Opportunities to provide clinical immersion experiences to bioengineering undergraduate students have expanded over the last several years. These programs allow students to observe the clinical environment in order to better understand workflow processes, the context in which medical equipment is used, and identify unmet needs firsthand. While each program focuses on identifying unmet needs, these experiences vary in content and implementation. Read More

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http://dx.doi.org/10.1007/s10439-020-02508-xDOI Listing

Muscular Thin Films for Label-Free Mapping of Excitation Propagation in Cardiac Tissue.

Ann Biomed Eng 2020 Apr 20. Epub 2020 Apr 20.

Laboratory of Biophysics of Excitable Systems, Moscow Institute of Physics and Technology, 9 Institutskiy Per., Dolgoprudny, Moscow Region, Russian Federation, 141701.

Muscular thin films (MTFs), have already found a variety of applications in cardiac tissue engineering and in building of lab-on-a-chip systems. Here we present a novel approach to label-free mapping of excitation waves in the cardiomyocyte cell cultures with the use of MTFs. Neonatal rat ventricular cardiomyocytes were cultured on polydimethylsiloxane (PDMS) thin films and observed by means of off-axis illumination. Read More

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http://dx.doi.org/10.1007/s10439-020-02513-0DOI Listing

Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues.

Ann Biomed Eng 2020 Apr 17. Epub 2020 Apr 17.

Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, 02912, USA.

Here we demonstrate a technique to generate proteomic signatures of specific cell types within heterogeneous populations. While our method is broadly applicable across biological systems, we have limited the current work to study neural cell types isolated from human, post-mortem Alzheimer's disease (AD) and aged-matched non-symptomatic (NS) brains. Motivating the need for this tool, we conducted an initial meta-analysis of current, human AD proteomics studies. Read More

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http://dx.doi.org/10.1007/s10439-020-02507-yDOI Listing

Quantifying the Multidimensional Impedance of the Shoulder During Volitional Contractions.

Ann Biomed Eng 2020 Apr 16. Epub 2020 Apr 16.

Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

The neuromuscular control of the shoulder requires regulation of 3D joint mechanics, but it is unknown how these mechanics vary during tasks that load the shoulder in different directions. The purpose of this study was to quantify how the 3D mechanics of the shoulder change with voluntary torque production. Eleven participants produced voluntary isometric torques in one of six directions along three measurement axes. Read More

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http://dx.doi.org/10.1007/s10439-020-02509-wDOI Listing

Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries.

Ann Biomed Eng 2020 Apr 16. Epub 2020 Apr 16.

Department of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

This study evaluates the feasibility of near infrared (NIR) spectroscopy to distinguish between different cartilage injury types associated with post-traumatic osteoarthritis and idiopathic osteoarthritis (OA) induced by mechanical and enzymatic damages. Bovine osteochondral samples (n = 72) were subjected to mechanical (n = 24) and enzymatic (n = 36) damage; NIR spectral measurements were acquired from each sample before and after damage, and from a separate control group (n = 12). Biomechanical measurements were then conducted to determine the functional integrity of the samples. Read More

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http://dx.doi.org/10.1007/s10439-020-02506-zDOI Listing

Dynamic Modulation of Device-Arterial Coupling to Determine Cardiac Output and Vascular Resistance.

Ann Biomed Eng 2020 Apr 13. Epub 2020 Apr 13.

Institute for Medical Engineering and Science, Massachusetts Institutes of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

Clinical adoption of mechanical circulatory support for shock is rapidly expanding. Achieving optimal therapeutic benefit requires metrics of state to guide titration and weaning of support. Using the transvalvular positioning of a percutaneous ventricular assist device (pVAD), device:heart interactions are leveraged to determine cardiac output (CO) and systemic vascular resistance (SVR) near-continuously without disrupting therapeutic function. Read More

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http://dx.doi.org/10.1007/s10439-020-02510-3DOI Listing

Perception-to-Image: Reconstructing Natural Images from the Brain Activity of Visual Perception.

Ann Biomed Eng 2020 Apr 13. Epub 2020 Apr 13.

MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.

The reappearance of human visual perception is a challenging topic in the field of brain decoding. Due to the complexity of visual stimuli and the constraints of fMRI data collection, the present decoding methods can only reconstruct the basic outline or provide similar figures/features of the perceived natural stimuli. To achieve a high-quality and high-resolution reconstruction of natural images from brain activity, this paper presents an end-to-end perception reconstruction model called the similarity-conditions generative adversarial network (SC-GAN), where visually perceptible images are reconstructed based on human visual cortex responses. Read More

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http://dx.doi.org/10.1007/s10439-020-02502-3DOI Listing

Comparative Study of Electrospun Scaffolds Containing Native GAGs and a GAG Mimetic for Human Mesenchymal Stem Cell Chondrogenesis.

Ann Biomed Eng 2020 Jul 13;48(7):2040-2052. Epub 2020 Apr 13.

Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights, Newark, NJ, 07102, USA.

Articular cartilage has limited healing and self-repair capability. Damage to articular cartilage becomes irreversible leading to osteoarthritis, which can impact a person's quality of life. Approximately, 5-10% of cartilage tissue is made up of sulfated glycosaminoglycans (GAGs), which sequester growth factors as well as provide structural integrity to the native cartilage tissue. Read More

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http://dx.doi.org/10.1007/s10439-020-02499-9DOI Listing