5,190 results match your criteria Annals of biomedical engineering[Journal]


Explicit Modeling of White Matter Axonal Fiber Tracts in a Finite Element Brain Model.

Ann Biomed Eng 2019 Mar 14. Epub 2019 Mar 14.

Center for Applied Biomechanics, University of Virginia, 4040 Lewis and Clark Dr, Charlottesville, VA, 22911, USA.

Many human brain finite element (FE) models lack mesoscopic (~ 1 mm) white matter structures, which may limit their capability in predicting TBI and assessing tissue-based injury metrics such as axonal strain. This study investigated an embedded method to explicitly incorporate white matter axonal fibers into an existing 50th percentile male brain model. The white matter was decomposed into myelinated axon tracts and an isotropic ground substance that had similar material properties to gray matter. Read More

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http://dx.doi.org/10.1007/s10439-019-02239-8DOI Listing

A Compliant Transoral Surgical Robotic System Based on a Parallel Flexible Mechanism.

Ann Biomed Eng 2019 Mar 12. Epub 2019 Mar 12.

Department of Biomedical Engineering, National University of Singapore, EA-05-30, 9 Engineering Drive 1, Singapore, 117575, Singapore.

Transoral robotic surgery (TORS) allows for access to oropharyngeal regions in an effective and minimally invasive manner. However, safe TORS access to deep pharyngeal (such as hypopharynx) sites remains a great challenge for current surgical robotic systems. In this work, we introduce a novel continuum robot with an optimized flexible parallel mechanism, to meet stringent requirements imposed by TORS on size, workspace, flexibility, and compliance. Read More

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http://link.springer.com/10.1007/s10439-019-02241-0
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http://dx.doi.org/10.1007/s10439-019-02241-0DOI Listing
March 2019
2 Reads

A Three-Dimensional Model of Human Lung Airway Tree to Study Therapeutics Delivery in the Lungs.

Ann Biomed Eng 2019 Mar 11. Epub 2019 Mar 11.

Department of Biomedical Engineering, The University of Akron, 260 S. Forge St., Akron, OH, 44325, USA.

Surfactant instillation into the lungs is used to treat several respiratory disorders such as neonatal respiratory distress syndrome (NRDS). The success of the treatments significantly depends on the uniformity of distribution of the instilled surfactant in airways. This is challenging to directly evaluate due to the inaccessibility of lung airways and great difficulty with imaging them. Read More

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http://link.springer.com/10.1007/s10439-019-02242-z
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http://dx.doi.org/10.1007/s10439-019-02242-zDOI Listing
March 2019
1 Read

Development of a Computational Method for Simulating Tricuspid Valve Dynamics.

Ann Biomed Eng 2019 Mar 11. Epub 2019 Mar 11.

The Wallace H. Coulter School of Biomedical Engineering, Georgia Institute of Technology & Emory University, Technology Enterprise Park, 387 Technology Circle, Atlanta, GA, 30313-2412, USA.

Computational modeling can be used to improve understanding of tricuspid valve (TV) biomechanics and supplement knowledge gained from benchtop and large animal experiments. The aim of this study was to develop a computational model of the TV using high resolution micro-computed tomography (μCT) imaging and fluid-structure interaction simulations. A three-dimensional TV model, incorporating detailed leaflet and chordal geometries, was reconstructed from μCT images of an excised porcine TV obtained under diastolic conditions. Read More

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http://link.springer.com/10.1007/s10439-019-02243-y
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http://dx.doi.org/10.1007/s10439-019-02243-yDOI Listing
March 2019
1 Read

Loads on Transhumeral Amputees Using Osseointegrated Prostheses.

Ann Biomed Eng 2019 Mar 11. Epub 2019 Mar 11.

Department of Orthopaedics, Gothenburg University, Gothenburg, Sweden.

The treatment of the upper extremities is not as prevalent as that of the lower limbs, but it is nonetheless equally important. Today, there are no load data relating to upper extremity bone-anchored prosthesis users in the literature, but they are important in order to improve the rehabilitation protocol, design aspects and confidence of the user when it comes to loading the prosthesis in daily life. The aim of the present study was to investigate, in a population of eleven transhumeral amputees with osseointegrated implants, the load levels reached during specific prosthetic movements at maximum voluntary effort and during daily activities. Read More

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http://dx.doi.org/10.1007/s10439-019-02244-xDOI Listing

The Effects of 4%Fe on the Performance of Pure Zinc as Biodegradable Implant Material.

Ann Biomed Eng 2019 Mar 8. Epub 2019 Mar 8.

Department of Materials Engineering, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel.

The efforts to develop structural materials for biodegradable metal implants have lately shifted their focus from Magnesium and Iron base alloys towards Zinc. This was mainly due to the accelerated corrosion rate of Mg that is accompanied by hydrogen gas evolution, formation of voluminous iron oxide products with reduced degradation rate in the case of Iron implants and the crucial role of Zn in many physiological processes. However the mechanical properties and degradation capabilities of pure zinc in physiological environment are limited and do not comply with the requirements of biodegradable implants. Read More

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http://dx.doi.org/10.1007/s10439-019-02245-wDOI Listing

Influence of Collaterals on True FFR Prediction for a Left Main Stenosis with Concomitant Lesions: An In Vitro Study.

Ann Biomed Eng 2019 Mar 6. Epub 2019 Mar 6.

Laboratory TIMC-IMAG, University Grenoble-Alpes, CNRS, UMR 5525, Grenoble, France.

With the aim of assisting interventional cardiologists during decision making for revascularization, reduced-order (0D) approaches have been developed to predict the true fractional flow reserve (FFR) of individual stenoses in multiple-lesion arrangements. In this study, a general equation was derived to predict the FFR of a left main (LM) coronary stenosis with downstream lesions, one in the left anterior descending (LAD) and the other in the left circumflex (LCx) artery, and distinct collateral circulations supplying each daughter artery. An in vitro model mimicking the fractal nature of LM bifurcation trees with collateral branches was developed to validate the FFR values obtained with the prediction model (FFR ). Read More

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http://dx.doi.org/10.1007/s10439-019-02235-yDOI Listing

Prediction of Individual Finger Forces Based on Decoded Motoneuron Activities.

Ann Biomed Eng 2019 Mar 4. Epub 2019 Mar 4.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, 27599, USA.

Accurate prediction of motor output based on neural signals is critical in human-machine interactions. The objective was to evaluate the performance of predicting individual finger forces through an estimation of the descending neural drive to the spinal motoneuron pool. High-density surface electromyogram (EMG) signals of the extensor digitorum communis muscle were obtained, and were then decomposed into individual motor unit discharge events. Read More

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http://dx.doi.org/10.1007/s10439-019-02240-1DOI Listing

A Battery-Powered Ankle Exoskeleton Improves Gait Mechanics in a Feasibility Study of Individuals with Cerebral Palsy.

Ann Biomed Eng 2019 Mar 1. Epub 2019 Mar 1.

Department of Mechanical Engineering, Northern Arizona University, 15600 S McConnell Drive, NAU EGR Bldg 69, Flagstaff, AZ, 86011, USA.

Neuromuscular impairment associated with cerebral palsy (CP) often leads to life-long walking deficits. Our goal was to evaluate the ability of a novel untethered wearable ankle exoskeleton to reduce the severity of gait pathology from CP. In this clinical feasibility study of five individuals with CP, we used instrumented gait analysis to quantify how powered plantar-flexor assistance affected gait mechanics following multi-visit acclimation. Read More

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http://dx.doi.org/10.1007/s10439-019-02237-wDOI Listing

Using Gait Variability to Predict Inter-individual Differences in Learning Rate of a Novel Obstacle Course.

Ann Biomed Eng 2019 Mar 1. Epub 2019 Mar 1.

Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, USA.

This study aimed to determine whether inter-individual differences in learning rate of a novel motor task could be predicted by movement variability exhibited in a related baseline task, and determine which variability measures best discriminate individual differences in learning rate. Thirty-two participants were asked to repeatedly complete an obstacle course until achieving success in a dual-task paradigm. Their baseline gait kinematics during self-paced level walking were used to calculate stride-to-stride variability in stride characteristics, joint angle trajectories, and inter-joint coordination. Read More

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http://dx.doi.org/10.1007/s10439-019-02236-xDOI Listing
March 2019
1 Read

Complete Myogenic Differentiation of Adipogenic Stem Cells Requires Both Biochemical and Mechanical Stimulation.

Ann Biomed Eng 2019 Feb 27. Epub 2019 Feb 27.

Lower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), Hannover Medical School, Stadtfelddamm 34, 30625, Hannover, Germany.

Vascular tissue engineering of the middle layer of natural arteries requires contractile smooth muscle cells (SMC) which can be differentiated from adipose-derived mesenchymal stem cells (ASC) by treatment with transforming growth factor-β, sphingosylphosphorylcholine and bone morphogenetic protein-4 (TSB). Since mechanical stimulation may support or replace TSB-driven differentiation, we investigated its effect plus TSB-treatment on SMC orientation and contractile protein expression. Tubular fibrin scaffolds with incorporated ASC or pre-differentiated SMC were exposed to pulsatile perfusion for 10 days with or without TSB. Read More

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http://dx.doi.org/10.1007/s10439-019-02234-zDOI Listing
February 2019
1 Read

2018 Athanasiou ABME Student Awards.

Authors:
Bethany Rowson

Ann Biomed Eng 2019 Feb 25. Epub 2019 Feb 25.

Department of Biomedical Engineering and Mechanics, Virginia Tech, 440 Kelly Hall, 325 Stanger St, Blacksburg, VA, 24061, USA.

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http://dx.doi.org/10.1007/s10439-019-02232-1DOI Listing
February 2019
1 Read

Electrode Placement Accuracy in Robot-Assisted Asleep Deep Brain Stimulation.

Ann Biomed Eng 2019 Feb 22. Epub 2019 Feb 22.

Mechanical and Biomedical Engineering, Boise State University, 1910 University Drive, MS-2085, Boise, ID, 83725-2085, USA.

Deep brain stimulation (DBS) involves the implantation of electrodes into specific central brain structures for the treatment of Parkinson's disease. Image guidance and robot-assisted techniques have been developed to assist in the accuracy of electrode placement. Traditional DBS is performed with the patient awake and utilizes microelectrode recording for feedback, which yields lengthy operating room times. Read More

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http://dx.doi.org/10.1007/s10439-019-02230-3DOI Listing
February 2019
1 Read

Transport Analysis of Engineered Liver Tissue Fabricated Using a Capsule-Based, Modular Approach.

Ann Biomed Eng 2019 Feb 22. Epub 2019 Feb 22.

Department of Biomedical Engineering, Wayne State University, Detroit, MI, 48202, USA.

The bioinspired, microscale tissue engineering approach has emerged in recent years as a promising alternative to preformed scaffolds. Using this approach, complex tissues and organs can be efficiently engineered from microscale modules to replicate the intricate architecture and physiology of vascularized organs and tissues. Previously, we demonstrated assembly of a prototype, engineered liver tissue, formed by the fusion of hepatocyte-containing capsules. Read More

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http://dx.doi.org/10.1007/s10439-018-02192-yDOI Listing
February 2019
1 Read

High-Resolution Body Surface Potential Mapping in Exercise Assessment of Ischemic Heart Disease.

Ann Biomed Eng 2019 Feb 21. Epub 2019 Feb 21.

I Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.

Standard 12-lead ECG exercise testing is commonly used for screening of ischemic heart disease (IHD). We studied if high-resolution body surface potential mapping (HR-BSPM) during exercise offers advantages over current standards in noninvasive evaluation of IHD. This study was carried out on 90 IHD patients and 33 healthy controls. Read More

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http://dx.doi.org/10.1007/s10439-019-02231-2DOI Listing
February 2019

Non-Destructive Reflectance Mapping of Collagen Fiber Alignment in Heart Valve Leaflets.

Ann Biomed Eng 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

Collagen fibers are the primary structural elements that define many soft-tissue structure and mechanical function relationships, so that quantification of collagen organization is essential to many disciplines. Current tissue-level collagen fiber imaging techniques remain limited in their ability to quantify fiber organization at macroscopic spatial scales and multiple time points, especially in a non-contacting manner, requiring no modifications to the tissue, and in near real-time. Our group has previously developed polarized spatial frequency domain imaging (pSFDI), a reflectance imaging technique that rapidly and non-destructively quantifies planar collagen fiber orientation in superficial layers of soft tissues over large fields-of-view. Read More

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http://dx.doi.org/10.1007/s10439-019-02233-0DOI Listing
February 2019
2 Reads

Computational Models for the Mechanical Investigation of Stomach Tissues and Structure.

Ann Biomed Eng 2019 Feb 19. Epub 2019 Feb 19.

Centre for Mechanics of Biological Materials, University of Padova, Via F. Marzolo 9, 35131, Padua, Italy.

Bariatric surgery is performed on obese people aiming at reducing the capacity of the stomach and/or the absorbing capability of the gastrointestinal tract. A more reliable and effective approach to bariatric surgery may integrate different expertise, in the areas of surgery, physiology and biomechanics, availing of a strong cooperation between clinicians and engineers. This work aimed at developing a computational model of the stomach, as a computational tool for the physio-mechanical investigation of stomach functionality and the planning of bariatric procedures. Read More

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http://dx.doi.org/10.1007/s10439-019-02229-wDOI Listing
February 2019
1 Read

Design and Implementation of a Novel Subject-Specific Neurofeedback Evaluation and Treatment System.

Ann Biomed Eng 2019 Feb 15. Epub 2019 Feb 15.

Occupational Therapy Department, School of Health Professions, Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, 6997801, Tel Aviv, Israel.

Electroencephalography (EEG)-based neurofeedback (NF) is a safe, non-invasive, non-painful method for treating various conditions. Current NF systems enable the selection of only one NF parameter, so that two parameters cannot be feedback simultaneously. Consequently, the ability to individually-tailor the treatment to a patient is limited, and treatment efficiency may therefore be compromised. Read More

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http://link.springer.com/10.1007/s10439-019-02228-x
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http://dx.doi.org/10.1007/s10439-019-02228-xDOI Listing
February 2019
8 Reads

Bone Density and Texture from Minimally Post-Processed Knee Radiographs in Subjects with Knee Osteoarthritis.

Ann Biomed Eng 2019 Feb 14. Epub 2019 Feb 14.

Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland.

Plain radiography is the most common modality to assess the stage of osteoarthritis. Our aims were to assess the relationship of radiography-based bone density and texture between radiographs with minimal and clinical post-processing, and to compare the differences in bone characteristics between controls and subjects with knee osteoarthritis or medial tibial bone marrow lesions (BMLs). Tibial bone density and texture was evaluated from radiographs with both minimal and clinical post-processing in 109 subjects with and without osteoarthritis. Read More

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http://link.springer.com/10.1007/s10439-019-02227-y
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http://dx.doi.org/10.1007/s10439-019-02227-yDOI Listing
February 2019
4 Reads

Authorship Trends Over the Past 30-Years in the Annals of Biomedical Engineering.

Ann Biomed Eng 2019 Feb 14. Epub 2019 Feb 14.

Department of Orthopaedic Surgery, Indiana University School of Medicine, 1130 West Michigan Street, FH 115, Indianapolis, IN, 46202, USA.

In academia, manuscripts serve as an important component of career development. The past several years have seen heightened evaluation of the role of the gender gap in career advancement, as well as other bibliometric changes in publications. We therefore analyzed authorship and publication trends in the Annals of Biomedical Engineering over the past three decades (one complete year of manuscripts for each decade; 1986, 1996, 2006, and 2016). Read More

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http://dx.doi.org/10.1007/s10439-019-02222-3DOI Listing
February 2019

A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium.

Ann Biomed Eng 2019 Feb 14. Epub 2019 Feb 14.

Hopkins Extreme Materials Institute, Johns Hopkins University, Baltimore, MD, USA.

We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. Read More

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http://dx.doi.org/10.1007/s10439-019-02226-zDOI Listing
February 2019
1 Read

Pulse Arrival Time and Pulse Interval as Accurate Markers to Detect Mechanical Alternans.

Ann Biomed Eng 2019 Feb 12. Epub 2019 Feb 12.

Department of Mechanical Engineering, University College London, London, UK.

Mechanical alternans (MA) is a powerful predictor of adverse prognosis in patients with heart failure and cardiomyopathy, but its use remains limited due to the need of invasive continuous arterial pressure recordings. This study aims to assess novel cardiovascular correlates of MA in the intact human heart to facilitate affordable and non-invasive detection of MA and advance our understanding of the underlying pathophysiology. Arterial pressure, respiration, and ECG were recorded in 12 subjects with healthy ventricles during voluntarily controlled breathing at different respiratory rate, before and after administration of beta-blockers. Read More

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http://dx.doi.org/10.1007/s10439-019-02221-4DOI Listing
February 2019
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A How-To Guide for Promoting Diversity and Inclusion in Biomedical Engineering.

Authors:
Naomi C Chesler

Ann Biomed Eng 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedical Engineering, University of Wisconsin-Madison College of Engineering, 2146 Engineering Centers Building, 1550 Engineering Drive, Madison, WI, 53706, USA.

To accelerate the development of an inclusive culture in biomedical engineering (BME), we must accept complexity, seek to understand our own privilege, speak out about diversity, learn the difference between intent and impact, accept our mistakes, and learn how to engage in difficult conversations. In turn, we will be rewarded by the ideas, designs, devices and discoveries of a new generation of problem solvers and thought leaders who bring diverse experiences and perspectives. Read More

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http://dx.doi.org/10.1007/s10439-019-02223-2DOI Listing
February 2019
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Probing the Depth of the Myocardium: Vasculature, Transit Time, and Perfusion Within the Left Ventricular Wall.

Ann Biomed Eng 2019 Feb 7. Epub 2019 Feb 7.

Departments of Applied Mathematics and of Medical Biophysics, The University of Western Ontario, London, ON, Canada.

The branching architecture of arterial trees traversing the thickness of the left ventricular wall is studied to determine the way in which adequate blood supply is provided to myocardial tissue at different depths within the wall thickness from arterial trees originating at the epicardial surface. The study is based on micro-CT images of tissue biopsies, coupled with a dedicated vascular tree analysis program. The results show that this combination of methodologies allows a more detailed and much more accurate exploration of the vasculature within the sampled tissue than is possible by histological means. Read More

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http://dx.doi.org/10.1007/s10439-019-02208-1DOI Listing
February 2019
1 Read

IGBT-Based Pulsed Electric Fields Generator for Disinfection: Design and In Vitro Studies on Pseudomonas aeruginosa.

Ann Biomed Eng 2019 Feb 6. Epub 2019 Feb 6.

Porter School of Environmental and Earth Sciences, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel.

Irreversible electroporation of cell membrane with pulsed electric fields is an emerging physical method for disinfection that aims to reduce the doses and volumes of used antibiotics for wound healing. Here we report on the design of the IGBT-based pulsed electric field generator that enabled eradication of multidrug resistant Pseudomonas aeruginosa PAO1 on the gel. Using a concentric electric configuration we determined that the lower threshold of the electric field required to kill P. Read More

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http://dx.doi.org/10.1007/s10439-019-02225-0DOI Listing
February 2019

Mitral Valve Prosthesis Design Affects Hemodynamic Stasis and Shear In The Dilated Left Ventricle.

Ann Biomed Eng 2019 Feb 6. Epub 2019 Feb 6.

Bioengineering Program, San Diego State University, 5500 Campanile Dr, San Diego, CA, 92182-1323, USA.

Dilated cardiomyopathy produces abnormal left ventricular (LV) blood flow patterns that are linked with thromboembolism (TE). We hypothesized that implantation of mechanical heart valves non-trivially influences TE risk in these patients, exacerbating abnormal LV flow dynamics. The goal of this study was to assess how mitral valve design impacts flow and hemodynamic factors associated with TE. Read More

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http://dx.doi.org/10.1007/s10439-019-02218-zDOI Listing
February 2019
1 Read

Spatiotemporal Complexity of the Aortic Sinus Vortex as a Function of Leaflet Calcification.

Ann Biomed Eng 2019 Apr 1;47(4):1116-1128. Epub 2019 Feb 1.

Department of Biomedical Engineering, The Ohio State University, 473 W 12th Ave, Columbus, OH, 43210, USA.

Several studies have shown the variation of aortic sinus structures' hemodynamics with different flow and geometric characteristics. They have also correlated aortic sinus hemodynamics with the progression and evolution of calcific aortic valve disease (CAVD). This study aims at visualizing aortic sinus fluid structure variations as functions of different leaflet calcification degrees and assessing their potential relationship with CAVD. Read More

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http://dx.doi.org/10.1007/s10439-019-02224-1DOI Listing

Regeneration of Diabetic Foot Ulcers Based on Therapy with Red LED Light and a Natural Latex Biomembrane.

Ann Biomed Eng 2019 Apr 1;47(4):1153-1164. Epub 2019 Feb 1.

Electronics and Automation Systems Engineering Program, Department of Electrical Engineering, Brasília, DF, 70.910-900, Brazil.

This study analyzes the effects of the Rapha system, which employs red light therapy (RLT) and a natural latex biomembrane in the healing of neuropathic ulcers associated with the diabetic foot. We conducted a randomized, controlled, blinded clinical trial with 15 participants that were divided into three groups (GI, GII and GIII): (i) Rapha system application by the participant and a health professional at home, with clinical status evaluation every 2 weeks at the hospital (GI); (ii) standard protocol used in Brazil, performed by a health professional at the hospital (GII; control); and (iii) the Rapha system applied by the participant at home and clinical status evaluation every 2 weeks at the hospital (GIII). We used image processing techniques on photographic recordings of the lesions, and several statistical tests were used to analyze the data, allowing for the comparison of the average results for all groups. Read More

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http://dx.doi.org/10.1007/s10439-019-02220-5DOI Listing
April 2019
2 Reads

Predictive Numerical Simulations of Double Branch Stent-Graft Deployment in an Aortic Arch Aneurysm.

Ann Biomed Eng 2019 Apr 31;47(4):1051-1062. Epub 2019 Jan 31.

Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, 158, cours Fauriel, 42023, Saint-Étienne, France.

Total endovascular repair of the aortic arch represents a promising option for patients ineligible to open surgery. Custom-made design of stent-grafts (SG), such as the Terumo Aortic RelayBranch device (DB), requires complex preoperative measures. Accurate SG deployment is required to avoid intraoperative or postoperative complications, which is extremely challenging in the aortic arch. Read More

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http://link.springer.com/10.1007/s10439-019-02215-2
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http://dx.doi.org/10.1007/s10439-019-02215-2DOI Listing
April 2019
4 Reads

Repeated In Vitro Impact Conditioning of Astrocytes Decreases the Expression and Accumulation of Extracellular Matrix.

Ann Biomed Eng 2019 Apr 31;47(4):967-979. Epub 2019 Jan 31.

Department of Biomedical Engineering, University of Arkansas, 125 Engineering Hall, Fayetteville, AR, 72701, USA.

Pathological changes to the physical and chemical properties of brain extracellular matrix (ECM) occur following injury. It is generally assumed that astrocytes play an important role in these changes. What remain unclear are the triggers that lead to changes in the regulation of ECM by astrocytes following injury. Read More

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http://dx.doi.org/10.1007/s10439-019-02219-yDOI Listing

A Bag of Wavelet Features for Snore Sound Classification.

Ann Biomed Eng 2019 Apr 30;47(4):1000-1011. Epub 2019 Jan 30.

ZD.B Chair of Embedded Intelligence for Health Care & Wellbeing, Universität Augsburg, Eichleitnerstr. 30, 86159, Augsburg, Germany.

Snore sound (SnS) classification can support a targeted surgical approach to sleep related breathing disorders. Using machine listening methods, we aim to find the location of obstruction and vibration within a subject's upper airway. Wavelet features have been demonstrated to be efficient in the recognition of SnSs in previous studies. Read More

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http://dx.doi.org/10.1007/s10439-019-02217-0DOI Listing
April 2019
2 Reads

Selection Procedures for the Largest Lyapunov Exponent in Gait Biomechanics.

Ann Biomed Eng 2019 Apr 30;47(4):913-923. Epub 2019 Jan 30.

Department of Biomechanics and Center for Research in Human Movement Variability, University of Nebraska at Omaha, 6160 University Drive, Omaha, NE, 68182-0860, USA.

The present study was aimed at investigating the effectiveness of the Wolf et al. (LyE_W) and Rosenstein et al. largest Lyapunov Exponent (LyE_R) algorithms to differentiate data sets with distinctly different temporal structures. Read More

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http://link.springer.com/10.1007/s10439-019-02216-1
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http://dx.doi.org/10.1007/s10439-019-02216-1DOI Listing
April 2019
3 Reads

Electrocardiogram Acquisition During Remote Magnetic Catheter Navigation.

Ann Biomed Eng 2019 Apr 30;47(4):1141-1152. Epub 2019 Jan 30.

IADI, INSERM, U1254 and Université de Lorraine, Nancy, France.

Electrocardiogram (ECG) acquisition is required during catheter treatment of cardiac arrhythmias. The remote magnetic navigation technology allows the catheter to be moved automatically inside the heart chambers using large external magnets. Each change of position of the catheter requires fast motion of the magnets, therefore magnetic fluxes are created through the ECG cables, causing large distortions of the ECG signals. Read More

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http://dx.doi.org/10.1007/s10439-019-02214-3DOI Listing
April 2019
1 Read

Finite Element Methods in Human Head Impact Simulations: A Review.

Ann Biomed Eng 2019 Jan 28. Epub 2019 Jan 28.

Department of Mechanical Science & Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Head impacts leading to traumatic brain injury (TBI) present a major health risk today, projected to become the third leading cause of death by 2020. While finite element (FE) models of the human brain are important tools to understand and mitigate TBI, many unresolved issues remain that need to be addressed to improve these models. This work aims to provide readers with background information regarding the current state of research in this field as well as to present recent advancements made possible by improvements to computational resources. Read More

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http://dx.doi.org/10.1007/s10439-019-02205-4DOI Listing
January 2019
1 Read

EIT Imaging of Upper Airway to Estimate Its Size and Shape Changes During Obstructive Sleep Apnea.

Ann Biomed Eng 2019 Apr 28;47(4):990-999. Epub 2019 Jan 28.

Department of Medical Engineering, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.

Noninvasive continuous imaging of the upper airway during natural sleep was conducted for patients with obstructive sleep apnea (OSA) using the electrical impedance tomography (EIT) technique. A safe amount of alternating current (AC) was injected into the lower head through multiple surface electrodes. Since the air is an electrical insulator, upper airway narrowing during OSA altered internal current pathways and changed the induced voltage distribution. Read More

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http://link.springer.com/10.1007/s10439-019-02210-7
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http://dx.doi.org/10.1007/s10439-019-02210-7DOI Listing
April 2019
6 Reads

Elastic, Viscoelastic and Fibril-Reinforced Poroelastic Material Properties of Healthy and Osteoarthritic Human Tibial Cartilage.

Ann Biomed Eng 2019 Apr 28;47(4):953-966. Epub 2019 Jan 28.

Department of Applied Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.

Articular cartilage constituents (collagen, proteoglycans, fluid) are significantly altered during osteoarthritis (OA). A fibril-reinforced poroelastic (FRPE) material model can separate the contribution of each constituent on the mechanical response of cartilage. Yet, these properties and their OA related alterations are not known for human tibial cartilage. Read More

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http://dx.doi.org/10.1007/s10439-019-02213-4DOI Listing

Efficacy of Sonothrombolysis Using Microbubbles Produced by a Catheter-Based Microfluidic Device in a Rat Model of Ischemic Stroke.

Ann Biomed Eng 2019 Apr 28;47(4):1012-1022. Epub 2019 Jan 28.

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.

Limitations of existing thrombolytic therapies for acute ischemic stroke have motivated the development of catheter-based approaches that utilize no or low doses of thrombolytic drugs combined with a mechanical action to either dissolve or extract the thrombus. Sonothrombolysis accelerates thrombus dissolution via the application of ultrasound combined with microbubble contrast agents and low doses of thrombolytics to mechanically disrupt the fibrin mesh. In this work, we studied the efficacy of catheter-directed sonothrombolysis in a rat model of ischemic stroke. Read More

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http://dx.doi.org/10.1007/s10439-019-02209-0DOI Listing
April 2019
2 Reads
3.195 Impact Factor

Fibroblast Growth Factor-2 Binding to Heparan Sulfate Proteoglycans Varies with Shear Stress in Flow-Adapted Cells.

Ann Biomed Eng 2019 Apr 28;47(4):1078-1093. Epub 2019 Jan 28.

Mechanical Engineering and Mechanics Department, Drexel University, 3141 Chestnut St, Philadelphia, PA, USA.

Fibroblast growth factor 2 (FGF2), an important regulator of angiogenesis, binds to endothelial cell (EC) surface FGF receptors (FGFRs) and heparan sulfate proteoglycans (HSPGs). FGF2 binding kinetics have been predominantly studied in static culture; however, the endothelium is constantly exposed to flow which may affect FGF2 binding. We therefore used experimental and computational techniques to study how EC FGF2 binding changes in flow. Read More

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http://link.springer.com/10.1007/s10439-019-02202-7
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http://dx.doi.org/10.1007/s10439-019-02202-7DOI Listing
April 2019
6 Reads

Fabrication of a Novel Absorbable Vascular Anastomosis Device and Testing in a Pig Liver Transplantation Model.

Ann Biomed Eng 2019 Apr 24;47(4):1063-1077. Epub 2019 Jan 24.

Department of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, Korea.

An absorbable vascular anastomosis device (AVAD) was fabricated and tested in pig liver transplantation experiments. We prepared biodegradable copolymers with various ratios of L-lactide: glycolide and tested their properties including inherent viscosity, in vitro biodegradation, and tensile strength. The mechanical and physical properties of the finally selected copolymers were analyzed according to decomposition time. Read More

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http://dx.doi.org/10.1007/s10439-019-02212-5DOI Listing

Anthropometric Scaling of Anatomical Datasets for Subject-Specific Musculoskeletal Modelling of the Shoulder.

Ann Biomed Eng 2019 Apr 24;47(4):924-936. Epub 2019 Jan 24.

Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.

Linear scaling of generic shoulder models leads to substantial errors in model predictions. Customisation of shoulder modelling through magnetic resonance imaging (MRI) improves modelling outcomes, but model development is time and technology intensive. This study aims to validate 10 MRI-based shoulder models, identify the best combinations of anthropometric parameters for model scaling, and quantify the improvement in model predictions of glenohumeral loading through anthropometric scaling from this anatomical atlas. Read More

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http://dx.doi.org/10.1007/s10439-019-02207-2DOI Listing

Elevated Microdamage Spatially Correlates with Stress in Metastatic Vertebrae.

Ann Biomed Eng 2019 Apr 23;47(4):980-989. Epub 2019 Jan 23.

Orthopaedics Biomechanics Laboratory, Sunnybrook Research Institute, Toronto, ON, Canada.

Metastasis of cancer to the spine impacts bone quality. This study aims to characterize vertebral microdamage secondary to metastatic disease considering the pattern of damage and its relationship to stress and strain under load. Osteolytic and mixed osteolytic/osteoblastic vertebral metastases were produced in athymic rats via HeLa cervical or canine Ace-1 prostate cancer cell inoculation, respectively. Read More

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http://dx.doi.org/10.1007/s10439-018-02188-8DOI Listing
April 2019
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An In-Vitro Flow Study Using an Artificial Circle of Willis Model for Validation of an Existing One-Dimensional Numerical Model.

Ann Biomed Eng 2019 Apr 23;47(4):1023-1037. Epub 2019 Jan 23.

Department of Mechanical and Materials Engineering, Wright State University, Dayton, OH, 45435, USA.

A one-dimensional (1D) numerical model has been previously developed to investigate the hemodynamics of blood flow in the entire human vascular network. In the current work, an experimental study of water-glycerin mixture flow in a 3D-printed silicone model of an anatomically accurate, complete circle of Willis (CoW) was conducted to investigate the flow characteristics in comparison with the simulated results by the 1D numerical model. In the experiment, the transient flow and pressure waveforms were measured at 13 selected segments within the flow network for comparisons. Read More

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http://dx.doi.org/10.1007/s10439-019-02211-6DOI Listing

Brain Injury and Impact Characteristics.

Ann Biomed Eng 2019 Jan 23. Epub 2019 Jan 23.

Department of Mechanical Engineering, Manhattan College, Bronx, NY, USA.

Almost all studies of traumatic brain injuries have only focused on the maximum acceleration associated with the impact. However, it has been noted that other impact characteristics should also be considered. This study has examined the effect on brain deformation [maximum principal strain (MPS)] associated with changing three characteristics of an isosceles trapezoid acceleration profile: initial slope (jerk), maximum acceleration, and impact energy (maximum velocity squared). Read More

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http://dx.doi.org/10.1007/s10439-019-02199-zDOI Listing
January 2019
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Identifying Local Arterial Stiffness to Assess the Risk of Rupture of Ascending Thoracic Aortic Aneurysms.

Ann Biomed Eng 2019 Apr 22;47(4):1038-1050. Epub 2019 Jan 22.

Mines Saint-Étienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, 42023, Saint-Étienne, France.

It was recently submitted that the rupture risk of an ascending thoracic aortic aneurysm (ATAA) is strongly correlated with the aortic stiffness. To validate this assumption, we propose a non-invasive inverse method to identify the patient-specific local extensional stiffness of aortic walls based on gated CT scans. Using these images, the local strain distribution is reconstructed throughout the cardiac cycle. Read More

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http://link.springer.com/10.1007/s10439-019-02204-5
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http://dx.doi.org/10.1007/s10439-019-02204-5DOI Listing
April 2019
5 Reads

The Effect of Formalin Preservation Time and Temperature on the Material Properties of Bovine Femoral Cortical Bone Tissue.

Ann Biomed Eng 2019 Apr 22;47(4):937-952. Epub 2019 Jan 22.

Department of Mechanical and Materials Engineering, Faculty of Engineering, School of Biomedical Engineering, Western University, London, ON, N6A 5B9, Canada.

Literature has reported controversial findings on whether formalin affected bone properties, or not, especially when different preservation time durations and temperatures were involved. Hence, accurately and systematically quantifying the effect of formalin on the mechanical properties of bone using a large dataset is crucial for assessing biomechanical responses based on fixed specimens. A total of 154 longitudinal and 149 transverse cuboid-shaped (12 mm × 2 mm × 0. Read More

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http://dx.doi.org/10.1007/s10439-019-02197-1DOI Listing

miR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification.

Ann Biomed Eng 2019 Apr 22;47(4):1106-1115. Epub 2019 Jan 22.

School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 387 Technology Circle NW, Technology Enterprise Park, Suite 200, Atlanta, GA, 30313, USA.

miR-214 has been recently found to be significantly downregulated in calcified human aortic valves (AVs). ER stress, especially the ATF4-mediated pathway, has also been shown to be significantly upregulated in calcific AV disease. Since elevated cyclic stretch is one of the major mechanical stimuli for AV calcification and ATF4 is a validated target of miR-214, we investigated the effect of cyclic stretch on miR-214 expression as well as those of ATF4 and two downstream genes (CHOP and BCL2L1). Read More

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http://dx.doi.org/10.1007/s10439-019-02206-3DOI Listing
April 2019
3.195 Impact Factor

Multi-Scale Modeling of Head Kinematics and Brain Tissue Response to Blast Exposure.

Ann Biomed Eng 2019 Jan 22. Epub 2019 Jan 22.

Department of MME, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.

Injuries resulting from blast exposure have been increasingly prevalent in recent conflicts, with a particular focus on the risk of head injury. In the current study, a multibody model (GEBOD) was used to investigate the gross kinematics resulting from blast exposure, including longer duration events such as the fall and ground impact. Additionally, detailed planar head models, in the sagittal and transverse planes, were used to model the primary blast wave interaction with the head, and resulting tissue response. Read More

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http://link.springer.com/10.1007/s10439-018-02193-x
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http://dx.doi.org/10.1007/s10439-018-02193-xDOI Listing
January 2019
7 Reads

A Mechanistic Analysis of Possible Blood Transfusion Failure to Increase Circulatory Oxygen Delivery in Anemic Patients.

Ann Biomed Eng 2019 Apr 18;47(4):1094-1105. Epub 2019 Jan 18.

Department of Energy Resources Engineering, Stanford University, 367 Panama Street, Stanford, CA, 94305, USA.

The effects of changing hematocrit (Hct) on the rate of circulatory oxygen ([Formula: see text]) delivery were modeled analytically to describe transfusion of 0.5-3.0 units of packed red blood cells (pRBC, 300 mL/unit, 60% Hct) to anemic patients. Read More

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http://dx.doi.org/10.1007/s10439-019-02200-9DOI Listing
April 2019
4 Reads

Prediction of Long Term Restenosis Risk After Surgery in the Carotid Bifurcation by Hemodynamic and Geometric Analysis.

Ann Biomed Eng 2019 Apr 18;47(4):1129-1140. Epub 2019 Jan 18.

PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

This study explored the potential of hemodynamic disturbances and geometric features to predict long-term carotid restenosis after carotid endarterectomy (CEA). Thirteen CEA for carotid diameter stenosis > 70% were performed with patch graft (PG) angioplasty in nine cases, and primary closure (PC) in four cases. MRI acquisitions within one month after CEA were used for hemodynamic and geometric characterization. Read More

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http://dx.doi.org/10.1007/s10439-019-02201-8DOI Listing
April 2019
1 Read

Alterations in Joint Angular Velocity Following Traumatic Knee Injury in Ovine Models.

Ann Biomed Eng 2019 Mar 17;47(3):790-801. Epub 2019 Jan 17.

McCaig Institute for Bone & Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Little effort has been directed towards the consequence of an injury on joint angular velocity. We hypothesized that the magnitude of knee joint angular velocity would be decreased after injury. Four injury groups were investigated in an ovine model: (1) anterior cruciate ligament (ACL) and medial collateral ligament (MCL) transection (ACL/MCL Tx) (n = 5), (2) lateral meniscectomy (Mx) (n = 5), (3) partial ACL transection (p-ACL Tx) (n = 5), and (4) partial-ACL and MCL transection (p-ACL/MCL Tx) (n = 5). Read More

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http://dx.doi.org/10.1007/s10439-019-02203-6DOI Listing
March 2019
7 Reads