771 results match your criteria Annals of Thoracic Medicine[Journal]


A COVID-19 family cluster with retinitis pigmentosa and hypogammaglobulinemia.

Ann Thorac Med 2022 Jan-Mar;17(1):66-69. Epub 2022 Jan 14.

College of Medicine, AlFaisal University, Riyadh, Kingdom of Saudi Arabia.

Hypogammaglobulinemia is a heterogeneous group of innate and acquired antibody deficiency with variable disease severity, recurrent pneumonia, and bronchiectasis. The outcome of COVID in patients with hypogammaglobulinemia is variable depending on age, comorbidities, type of immunodeficiency, and use of immunoglobulins. We report the favorable outcome of two family members diagnosed with -related retinitis pigmentosa and hypogammaglobulinemia syndrome and infected with SARS-CoV-2 following contact with their mother who had COVID-19. Read More

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January 2022

Characteristics and outcome of tertiary care critically ill COVID-19 patients with multiple comorbidities admitted to the intensive care unit.

Ann Thorac Med 2022 Jan-Mar;17(1):59-65. Epub 2022 Jan 14.

King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

Purpose: We conducted this study to evaluate the characteristics and outcomes exclusively in high-risk coronavirus disease 2019 (COVID-19) tertiary care patients with multiple comorbidities, as very few have reported outcomes in this specific cohort.

Methods: All patients, with two or more risk factors for COVID-19 and Charlson Comorbidity Index (CCI) of >2, who were admitted to intensive care unit (ICU) between March and December 2020 were included. Their characteristics, ICU course, and outcomes as well as differences between nonsurvivors and survivors were evaluated. Read More

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January 2022

Surgical and mediastinal emphysema in critically ill COVID-19 patients: A multicentric experience.

Ann Thorac Med 2022 Jan-Mar;17(1):51-58. Epub 2022 Jan 14.

Department of Surgery, Qatif Central Hospital, Qatif, Saudi Arabia.

Introduction: Coronavirus illness 2019, commonly referred to as COVID-19, is a highly infectious disease brought on by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 was declared a universal pandemic in March 2020 by the World Health Organization and is a severe health issue with unprecedented morbidity and mortality rates. Both surgical and mediastinal emphysema have been seen in cases of critically ill COVID-19 patients in several hospitals in the Eastern Province of Saudi Arabia. Read More

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January 2022

Surgical treatment outcomes of pulmonary inflammatory myofibroblastic tumors.

Ann Thorac Med 2022 Jan-Mar;17(1):44-50. Epub 2022 Jan 14.

Department of Thoracic Surgery, Faculty of Medicine, University of Erciyes, Kayseri, Turkey.

Background: Pulmonary inflammatory myofibroblastic tumor (PIMT) is an extremely rare disease. The aim of this study was to share the surgical outcomes of these tumors.

Methods: Patients who were operated for pulmonary myofibroblastic tumors between January 2005 and January 2021 were determined by retrospectively scanning patient files. Read More

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January 2022

Humidification during mechanical ventilation to prevent endotracheal tube occlusion in critically ill patients: A case control study.

Ann Thorac Med 2022 Jan-Mar;17(1):37-43. Epub 2022 Jan 14.

Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.

Background: Endotracheal tube (ETT) occlusion is a potentially life-threatening event. This study describes a quality improvement project to prevent ETT occlusion in critically ill patients.

Methods: After a cluster of clinically significant ETT occlusion incidents at a tertiary-care intensive care unit (ICU), the root cause analysis suggested that the universal use of heat moisture exchangers (HMEs) was a major cause. Read More

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January 2022

Long-term COVID-19 effects on pulmonary function, exercise capacity, and health status.

Ann Thorac Med 2022 Jan-Mar;17(1):28-36. Epub 2022 Jan 14.

Department of Radiodiagnosis, Faculty of Medicine, Assiut University, Egypt.

Background: The long-term effects of respiratory function and related physiological characteristics of coronavirus disease 2019 (COVID-19) survivors have not yet been studied in depth.

Objective: To examine pulmonary function, exercise capacity, and health-related quality of life among COVID-19 survivors.

Methods: Eighty-five survivors with confirmed COVID-19 were evaluated at the end of 3 and 6 months after disease onset. Read More

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January 2022

Sleep quality and mental health in coronavirus disease 2019 patients and general population during the pandemic.

Ann Thorac Med 2022 Jan-Mar;17(1):21-27. Epub 2022 Jan 14.

Sleep Medicine Research Group, Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Objective: Sleep problems during the coronavirus disease 2019 (COVID-19) pandemic commonly affected general populations. Data on the effect of the COVID-19 pandemic on sleep quality in Saudi Arabia are scarce. Thus, the aim of our study was to evaluate sleep quality and assess the psychological burden of the pandemic in COVID-19 patients and the general population. Read More

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January 2022

Effects of transcutaneous electrical diaphragmatic stimulation on respiratory function in patients with prolonged mechanical ventilation.

Ann Thorac Med 2022 Jan-Mar;17(1):14-20. Epub 2022 Jan 14.

Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taiwan.

Purpose: Muscle atrophy and diaphragm dysfunction are common with prolonged mechanical ventilation (PMV). Electrical stimulation on peripheral muscles has been shown to be beneficial in the improvement of muscle function. This study examined the effects of transcutaneous electrical diaphragmatic stimulation (TEDS) on respiratory muscle strength and weaning outcomes in patients with PMV. Read More

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January 2022

COVID-19 vaccine-induced immune thrombotic thrombocytopenia: A review.

Ann Thorac Med 2022 Jan-Mar;17(1):1-13. Epub 2022 Jan 14.

Department of Pulmonary and Critical Care, Pt B. D. Sharma, Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus responsible for the pandemic coronavirus disease 19 (COVID-19). It has significant impact on human health and public safety along with negative social and economic consequences. Vaccination against SARS-CoV-2 is likely the most effective approach to sustainably control the global COVID-19 pandemic. Read More

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January 2022

Two cases of bronchial anthracofibrosis combined with tuberculosis.

Ann Thorac Med 2021 Oct-Dec;16(4):361-365. Epub 2021 Oct 26.

Department of Respiratory and Critical Care Medicine, Xianyang Central Hospital, Xianyang, Shaanxi, China.

Background: Bronchial anthracofibrosis is a common disease that has been reported in the past. We aim to summarize the clinical characteristics of bronchial anthracofibrosis combined with tuberculosis infection to reduce missed diagnosis.

Methods: The clinical features of two cases of bronchial anthracofibrosis combined with tuberculosis were analyzed retrospectively, and relevant studies were reviewed. Read More

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October 2021

The effects of the COVID-19 lockdown on severe asthma in patients taking biologic therapy and air pollution in Riyadh.

Ann Thorac Med 2021 Oct-Dec;16(4):354-360. Epub 2021 Oct 26.

Department of Medicine, College of Medicine, King Saud University for Health Sciences, Riyadh, Saudi Arabia.

Background: The curfews and lockdowns imposed during the COVID-19 pandemic may decreased the volume of traffic and reduced air pollution. In addition, social distancing measures may contribute to reducing infection and asthma exacerbation.

Objective: The objective of this study was to assess asthma control and asthma medication use among severe asthmatics on biologics before and after the COVID-19 pandemic. Read More

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October 2021

Clinical and physiological characteristics of, medically treated, chronic thromboembolic pulmonary hypertension patients in Saudi Arabia: A single center experience.

Ann Thorac Med 2021 Oct-Dec;16(4):347-353. Epub 2021 Oct 26.

Department of Medicine, Division of Pulmonary Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is uncommon but well-known sequel of venous thromboembolism (VTE). At present, it is the only potential curable subtype of pulmonary hypertension. The aim of this study is to describe the medically treated-CTEPH patients' characteristics in a single specialized PH center in Saudi Arabia. Read More

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October 2021

Efficacy of acetazolamide for the prophylaxis of acute mountain sickness: A systematic review, meta-analysis, and trial sequential analysis of randomized clinical trials.

Ann Thorac Med 2021 Oct-Dec;16(4):337-346. Epub 2021 Oct 26.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Background: Acute mountain sickness (AMS) is a benign and self-limiting syndrome, but can progress to life-threatening conditions if leave untreated. This study aimed to assess the efficacy of acetazolamide for the prophylaxis of AMS, and disclose factors that affect the treatment effect of acetazolamide.

Methods: Randomized controlled trials comparing the use of acetazolamide versus placebo for the prevention of AMS were included. Read More

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October 2021

Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea.

Ann Thorac Med 2021 Oct-Dec;16(4):329-336. Epub 2021 Sep 15.

Department of Child Health, Child Health Research Institute, The University of Missouri School of Medicine, Columbia, MO, USA.

Background: Previous studies have reported increased levels of inflammatory mediators in patients with obstructive sleep apnea (OSA), but their relation with the severity of OSA is controversial.

Objective: To address potential relationships between OSA-related inflammatory markers, namely, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and fibrinogen, with different oxygenation parameters and with BMI.

Methods: All eligible patients with suspected OSA newly referred to the Sleep Medicine Research Center at King Abdulaziz University Hospital, Jeddah, were evaluated demographically and anthropometrically, and underwent overnight polysomnography. Read More

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September 2021

Drug susceptibility profiling of pulmonary and its correlation with treatment outcome.

Ann Thorac Med 2021 Oct-Dec;16(4):323-328. Epub 2021 Oct 26.

Department of Bacteriology, ICMR -National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.

Objectives: With the introduction of newer molecular diagnostic tools to identify , an increasing number of nontuberculous mycobacterium (NTM) is being identified. However, the drug resistance pattern of the NTM species identified is less explored. The objective of this study is to study the drug resistance patterns of species isolated in a tuberculosis-endemic setting at South India. Read More

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October 2021

Bilevel positive airway pressure ventilation for non-COPD acute hypercapnic respiratory failure patients: A systematic review and meta-analysis.

Ann Thorac Med 2021 Oct-Dec;16(4):306-322. Epub 2021 Oct 26.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

The effectiveness of bi-level positive airway pressure (BiPAP) in patients with acute hypercapnic respiratory failure (AHRF) due to etiologies other than chronic obstructive pulmonary disease (COPD) is unclear. To systematically review the evidence regarding the effectiveness of BiPAP in non-COPD patients with AHRF. The Cochrane Library, MEDLINE, EMBASE, and CINAHL Plus were searched according to prespecified criteria (PROSPERO-CRD42018089875). Read More

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October 2021

Pulmonary rehabilitation for COPD: A narrative review and call for further implementation in Saudi Arabia.

Ann Thorac Med 2021 Oct-Dec;16(4):299-305. Epub 2021 Oct 26.

UCL Respiratory, Royal Free Campus, University College London, London, UK.

Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable condition, in which outcomes can be improved with careful management. Pulmonary rehabilitation (PR) comprises exercise and education, delivered by multidisciplinary teams. PR is a cost-effective management strategy in COPD patients which improves exercise performance, reduces dyspnea, reduces the risk of exacerbation, and improves health-related quality of life. Read More

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October 2021

Fatal rapidly progressive interstitial lung disease in a patient with amyopathic dermatomyositis.

Ann Thorac Med 2021 Jul-Sep;16(3):294-298. Epub 2021 Jul 20.

Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Interstitial lung disease (ILD) is a well-established common manifestation of idiopathic inflammatory myopathies. Yet, till now, the pathogenetic mechanisms are still poorly understood, classification is evolving and prognosis is variable. A refractory and rapidly progressive ILD (RPILD) that is associated with dermatomyositis (DM) with minimal muscle weakness and normal creatine kinase (termed clinically amyopathic DM) is increasingly being recognized, with more incidence in Asians. Read More

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Molecular detection of plasmid-derived AmpC β-lactamase among clinical strains of in Bahrain.

Ann Thorac Med 2021 Jul-Sep;16(3):287-293. Epub 2021 Feb 19.

Departments of Microbiology, Immunology and Infectious Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.

Background: with AmpC β-lactamase are multidrug-resistant organisms and represent a significant challenge to patient care. This study aims to determine the prevalence of plasmid-derived AmpC β-lactamase among extended spectrum β-lactamases (ESBL)-producing strains in Bahrain.

Methods: It was a cross-sectional study. Read More

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February 2021

Clinical profiles associated with SARS-CoV-2 infection and complications from coronavirus disease-2019 in children from a national registry in Saudi Arabia.

Ann Thorac Med 2021 Jul-Sep;16(3):280-286. Epub 2021 Jul 20.

Department of Emergency Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Context: Exploring clinical characteristics of coronavirus disease-19 (COVID-19) in children may help in prevention and treatment guidelines.

Aims: The aim of the to describe the spectrum of pediatric COVID-19 in Saudi Arabia.

Settings And Design: A multicenter, retrospective, cross-sectional study involving pediatric COVID-19 patients across all Saudi regions. Read More

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Pulmonary neuroendocrine carcinoid tumors: Is there a predictive role to the Ki 67 index?

Ann Thorac Med 2021 Jul-Sep;16(3):274-279. Epub 2021 Jul 20.

Department of Thoracic Surgery and Pathology, Instituto Médico Especializado, Alexander Fleming, Buenos Aires, Argentina.

Introduction: There are several factors predicting evolution in carcinoid tumors (CT) to date including the Ki67 role.

Aims: The aim of this study is to identify a KI67 cut-off point for a population of CT and determine its prognostic implication in global and disease-free survival.

Methods: Hematoxylin-eosin slides of 102 CT were revised. Read More

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Point-of-care diagnostic lung ultrasound is highly applicable to the practice of medicine in Saudi Arabia but the current skills gap limits its use.

Ann Thorac Med 2021 Jul-Sep;16(3):266-273. Epub 2021 Jul 20.

Division of Internal Medicine, Department of Medicine, King Abdulaziz Medical City, King Abdullah International Medical Research Center, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.

Context: Coronavirus disease 2019 (COVID-19) has put a spotlight on point-of-care diagnostic lung ultrasound (POCDLUS). However, the spectra of respiratory disease and resources available for investigation vary internationally. The applicability of POCDLUS to internal medicine (IM) practice in Saudi Arabia and the current use by Saudi physicians are unknown. Read More

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Post-COVID-19 functional status: Relation to age, smoking, hospitalization, and previous comorbidities.

Ann Thorac Med 2021 Jul-Sep;16(3):260-265. Epub 2021 Jul 20.

Faculty of Medicine, Aswan Faculty of Medicine, Aswan University, Aswan, Egypt.

Rational: Recently, a new "Post-COVID-19 Functional Status (PCFS) scale" is recommended in the current COVID-19 pandemic. It is proposed that it could be used to display direct retrieval and the functional sequelae of COVID-19.

Aim Of The Study: The aim of the study was to assess the PCFS and to evaluate if age, gender, smoking, hospitalization, and comorbidities have any effect on functional limitations in recovered COVID-19 patients. Read More

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Small-airway disease and its reversibility in human immunodeficiency virus-infected children on highly active antiretroviral therapy: A cross-sectional study in an African setting.

Ann Thorac Med 2021 Jul-Sep;16(3):253-259. Epub 2021 Jul 20.

Department of Pediatrics, College of Medicine, University of Nigeria Ituku-Ozalla Enugu Campus, Enugu, Nigeria.

Background: Lung function abnormalities may occur in children with human immunodeficiency virus (HIV) infection. Small-airway disease (SAD) precedes abnormalities in forced expiratory volume in 1 s (FEV ).

Objective: This study aims to assess the presence and reversibility of SAD in HIV-infected children using the Global Lung Function Initiative standards. Read More

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The efficacy of airway pressure release ventilation in acute respiratory distress syndrome adult patients: A meta-analysis of clinical trials.

Ann Thorac Med 2021 Jul-Sep;16(3):245-252. Epub 2021 Jul 20.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

Background: To recruit poorly ventilated lung areas by providing active and adequate oxygenation is a core aspect of treating patients with acute respiratory distress syndrome (ARDS). The airway pressure release ventilation (APRV) mode is increasingly accepted as a means of supporting patients with ARDS. This study aimed to determine whether the APRV mode is effective in improving oxygenation, compared to conventional ventilation, in adult ARDS patients. Read More

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The recommended amount of physical activity, sedentary behavior, and sleep duration for healthy Saudis: A joint consensus statement of the Saudi Public Health Authority.

Ann Thorac Med 2021 Jul-Sep;16(3):239-244. Epub 2021 Jul 20.

Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia.

Background: The goal of the 24-h Movement Practice Guidelines for Saudi Arabia is to provide policymakers, health-care providers, researchers, sports professionals, and members of the public with recommendations on the duration of time they should spend engaged in physical activity, sedentary behavior, and sleep throughout all age groups.

Methods: A modified RAND appropriateness method and the "GRADE-ADOLOPMENT" approach of guideline recommendations were used by a guideline development panel to develop the present recommendations.

Results: The recommendations were based on the integrated needs of the following age groups: children (0-2 years), preschoolers (3-5 years), children and adolescents (6-17 years), adults (18-64 years), and older adults (≥65 years). Read More

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Joint consensus statement of the Saudi Public Health Authority on the recommended amount of physical activity, sedentary behavior, and sleep duration for healthy Saudis: Background, methodology, and discussion.

Ann Thorac Med 2021 Jul-Sep;16(3):225-238. Epub 2021 Jul 20.

Saudi Public Health Authority, Riyadh, Saudi Arabia.

The Saudi Public Health Authority recently prepared a Consensus Statement regarding how much time a person should spend engaged in physical activity, sedentary behavior, and sleep to promote optimal health across all age groups. This paper describes the background literature, methodology, and modified RAND Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-ADOLOPMENT approach that guided the development process. A Leadership Group and Consensus Panels were formed, and credible existing guidelines were identified. Read More

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Gone with the wind! Changes in the practice of bronchoscopy post pandemic: A perspective.

Ann Thorac Med 2021 Jul-Sep;16(3):221-224. Epub 2021 Jul 20.

Respiratory Medicine, Lancashire Teaching Hospitals, Preston, UK.

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E-cigarettes in the COVID-19 era.

Ann Thorac Med 2021 Apr-Jun;16(2):219-220. Epub 2021 Apr 17.

Department of Dermatology, Faculty of Medicine FMUSP, Laboratory of Dermatology and Immunodeficiencies (LIM - 56), University of São Paulo, Sao Paulo, Brazil. E-mail:

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Application of aerosol therapy in respiratory diseases in children: A Saudi expert consensus.

Ann Thorac Med 2021 Apr-Jun;16(2):188-218. Epub 2021 Apr 17.

Department of Pediatrics, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

The Saudi Pediatric Pulmonology Association (SPPA) is a subsidiary of the Saudi Thoracic Society (STS), which consists of a group of Saudi experts with well-respected academic and clinical backgrounds in the fields of asthma and other respiratory diseases. The SPPA Expert Panel realized the need to draw up a clear, simple to understand, and easy to use guidance regarding the application of different aerosol therapies in respiratory diseases in children, due to the high prevalence and high economic burden of these diseases in Saudi Arabia. This statement was developed based on the available literature, new evidence, and experts' practice to come up with such consensuses about the usage of different aerosol therapies for the management of respiratory diseases in children (asthma and nonasthma) in different patient settings, including outpatient, emergency room, intensive care unit, and inpatient settings. Read More

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