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    584 results match your criteria Annals of Thoracic Medicine [Journal]

    1 OF 12

    Rituximab treatment in patients with systemic sclerosis and interstitial lung disease.
    Ann Thorac Med 2017 Oct-Dec;12(4):294-297
    Department of Medical Specialties, Rheumatology Section, King Fahad Medical City, Riyadh, KSA.
    There is increasing interest in rituximab (RTX) as an alternative to cyclophosphamide for the treatment of interstitial lung diseases (ILDs) associated with systemic sclerosis (SSc). However, no report has addressed its efficacy in Saudi patients with SSc-ILD. To assess the efficacy of RTX treatment in Saudi patients with SSc-ILD, hospital records were reviewed between 2013 and 2016. Read More

    A novel cystic fibrosis gene mutation c.2490insT in a Palestinian patient: A case report and review of the literature.
    Ann Thorac Med 2017 Oct-Dec;12(4):290-293
    Department of Pathology and Laboratory Medicine, Medical Genetics Unit, American University of Beirut Medical Center, Beirut, Lebanon.
    We report the case of a 19-year-old male patient of Palestinian descent, who presented with a 1-year history of recurrent Pseudomonas aeruginosa respiratory infections, weight loss, chronic diarrhea, and a normal chloride sweat test. A panel for common cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations test was also negative. Cystic fibrosis (CF) was still clinically suspected thus, full CFTR gene sequencing was performed, which revealed a homozygous unreported mutation c. Read More

    Thromboprophylaxis and mortality among patients who developed venous thromboembolism in seven major hospitals in Saudi Arabia.
    Ann Thorac Med 2017 Oct-Dec;12(4):282-289
    Department of Surgery, Um Al-Qura University, Makkah, Saudi Arabia.
    Introduction: Venous thromboembolism (VTE) during hospitalization is a serious and potentially fatal condition. Despite its effectiveness, evidence-based thromboprophylaxis is still underutilized in many countries including Saudi Arabia.

    Objective Of The Study: Our objectives were to determine how often hospital-acquired VTE patients received appropriate thromboprophylaxis, VTE-associated mortality, and the percentage of patients given anticoagulant therapy and adherence to it after discharged. Read More

    Lung granuloma: A clinicopathologic study of 158 cases.
    Ann Thorac Med 2017 Oct-Dec;12(4):278-281
    Department of Medicine, Pulmonary Division, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
    Background And Aims: A granuloma is a common pathological diagnosis in lung biopsies and is caused by a variety of etiologies. The aim of this study was to assess the etiology and frequency of different cases of lung granulomas.

    Methods: The medical records of all patients who had lung granulomas between 2005 and 2013 were retrospectively reviewed. Read More

    Coronary flow reserve is impaired in patients with obstructive sleep apnea.
    Ann Thorac Med 2017 Oct-Dec;12(4):272-277
    Department of Pulmonary Medicine, Faculty of Medicine, Baskent University, Ankara, Turkey.
    Study Objectives: Obstructive sleep apnea (OSA) is common in adult populations. Accumulating data indicate that it is independently associated with a variety of cardiovascular diseases and has prognostic importance in affected cases. In this study, we aimed to evaluate coronary flow reserve (CFR) in patients with OSA and controls. Read More

    Pleuropulmonary manifestation in patients with rheumatoid arthritis in Saudi Arabia.
    Ann Thorac Med 2017 Oct-Dec;12(4):266-271
    Department of Internal Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    Background And Objectives: Pleuropulmonary (PP) involvement in rheumatoid arthritis (RA) is associated with high morbidity and mortality. Nevertheless, limited data are available regarding lung complications in the Middle East, especially in Saudi Arabia. The objectives of the current study were to determine the prevalence of PP manifestations and to identify the associated risk factors. Read More

    Characteristics and predictors of mortality of patients with hematologic malignancies requiring invasive mechanical ventilation.
    Ann Thorac Med 2017 Oct-Dec;12(4):259-265
    Department of Intensive Care, King Abdulaziz Medical City, College of Medicine, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh 11426, Saudi Arabia.
    Rationale: Acute respiratory failure (ARF) may complicate the course of hematologic malignancies (HMs). Our objective was to study the characteristics, outcomes and predictors of mortality of patients with HMs who required intubation for ARF.

    Methods: This retrospective cohort study evaluated all patients with HMs who were admitted to the Intensive Care Unit (ICU) of King Abdul-Aziz Medical City-Riyadh between 2008 and 2013 and required invasive mechanical ventilation. Read More

    Analysis of predictive parameters for the development of radiation-induced pneumonitis.
    Ann Thorac Med 2017 Oct-Dec;12(4):252-258
    Department of Internal Medicine, Division of Respiratory Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
    Introduction: Prevention and effective treatment of radiation-induced pneumonitis (RP) could facilitate greater use of radiation therapy (RT) for lung cancer. The purpose of this study was to determine clinical parameters useful for early prediction of RP.

    Methods: Blood sampling, pulmonary function testing, chest computed tomography, and bronchoalveolar lavage (BAL) were performed in patients with pathologically confirmed lung cancer who had completed ≥60 Gy of RT, at baseline, shortly after RT, and at 1 month posttreatment. Read More

    Sleep disturbances and memory impairment among pregnant women consuming khat: An under-recognized problem.
    Ann Thorac Med 2017 Oct-Dec;12(4):247-251
    University Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Khat (Catha edulis) is a evergreen flowering shrub that is cultivated at high altitudes, especially in East Africa and the southwest of the Arabian Peninsula. The plant contains alkaloids, of which cathinone and cathine have structural similarity and pharmacological action similar to amphetamines. The leaves are, therefore, consumed in some regions as a psychoactive stimulant due to cultural beliefs and misperceptions on the health benefits of khat consumption. Read More

    Saudi lung cancer management guidelines 2017.
    Ann Thorac Med 2017 Oct-Dec;12(4):221-246
    Department of Oncology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
    Background: Lung cancer management is getting more complex due to the rapid advances in all aspects of diagnostic and therapeutic options. Developing guidelines is critical to help practitioners provide standard of care.

    Methods: The Saudi Lung Cancer Guidelines Committee (SLCGC) multidisciplinary members from different specialties and from various regions and healthcare sectors of the country reviewed and updated all lung cancer guidelines with appropriate labeling of level of evidence. Read More

    Prevalence of antibodies against the Middle East Respiratory Syndrome coronavirus, influenza A and B viruses among blood donors, Saudi Arabia.
    Ann Thorac Med 2017 Jul-Sep;12(3):217-218
    Department of Intensive Care, College of Medicine, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia E-mail:

    The most frequent ABCA3 nonsense mutation -p.Tyr1515* (Y1515X) causing lethal neonatal respiratory failure in a term neonate.
    Ann Thorac Med 2017 Jul-Sep;12(3):213-215
    Genetic Department, Henri Mondor Hospital, France.
    Defects in the surfactant biosynthesis are associated with respiratory distress syndrome, commonly occurring in premature infants due to lung immaturity. However, interstitial lung diseases have also been observed in full-term infants with mutations in the SFTPC, SFTPB, NKX2-1, or ABCA3 genes, involved in the surfactant metabolism. Herein, we report a newborn baby with neonatal respiratory distress and diffuse lung disease caused by ABCA3 mutation. Read More

    Severe fibrosing mediastinitis with atypical presentation: Effective control with novel therapeutic approach.
    Ann Thorac Med 2017 Jul-Sep;12(3):209-212
    Department of Cardiac Sciences, King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Fibrosing mediastinitis (FM), also known as sclerosing mediastinitis, is an uncommon but serious disease involving the mediastinal structures. A high index of suspicion is essential to establish the diagnosis of FM and starting the appropriate therapy for patients. Here, we report a case of a young female who presented with chest symptoms and subsequently underwent different laboratory and radiologic investigations and an excisional biopsy. Read More

    Pulmonary consequences of hypothyroidism.
    Ann Thorac Med 2017 Jul-Sep;12(3):204-208
    Department of Chest, Faculty of Medicine, Assiut University Hospital, Assuit, Egypt.
    Background: Although hypothyroidism has an insidious onset and relatively asymptomatic, exertional dyspnea and fatigue can be the presenting complaints.

    Objectives: The aim is to assess functional lung impairment in hypothyroid patients both at rest and during exercise.

    Methods: A case-control study was carried out on 42 patients with newly diagnosed hypothyroidism and 12 control subjects. Read More

    Assessment of anti-factor Xa activity of enoxaparin for venous thromboembolism prophylaxis in morbidly obese surgical patients.
    Ann Thorac Med 2017 Jul-Sep;12(3):199-203
    Department of Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
    Background: Venous thromboembolism (VTE) can be encountered by 60% of hospitalized patients. Anticoagulants have been recommended to reduce the risk of VTE in patients with risk factors. However, no specific dosing recommendations for obese patients are provided in the current practice guidelines. Read More

    Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: An autopsy study.
    Ann Thorac Med 2017 Jul-Sep;12(3):191-198
    Institute of Pathology, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
    Introduction: Lung cancer is among leading causes of death worldwide. Different histological types of the lung carcinoma show significant differences in behavior.

    Objectives: The aim of this study is to determine the distribution patterns of metastases of different lung cancer histological types in autopsied individuals. Read More

    The influence of intermittent fasting on the circadian pattern of melatonin while controlling for caloric intake, energy expenditure, light exposure, and sleep schedules: A preliminary report.
    Ann Thorac Med 2017 Jul-Sep;12(3):183-190
    Department of Physiology, King Saud University, Riyadh, Saudi Arabia.
    Aims: We hypothesized that if we control for food composition, caloric intake, light exposure, sleep schedule, and exercise, intermittent fasting would not influence the circadian pattern of melatonin. Therefore, we designed this study to assess the effect of intermittent fasting on the circadian pattern of melatonin.

    Methods: Eight healthy volunteers with a mean age of 26. Read More

    What should be the appropriate minimal duration for patient examination and evaluation in pulmonary outpatient clinics?
    Ann Thorac Med 2017 Jul-Sep;12(3):177-182
    Celal Bayar University Medical Faculty, Department of Chest Diseases, Manisa, Turkey.
    Introduction: Patient examinations performed in a limited time period may lead to impairment in patient and physician relationship, defective and erroneous diagnosis, inappropriate prescriptions, less common use of preventive medicine practices, poor patient satisfaction, and increased violent acts against health-care staff.

    Objective: This study aimed to determine the appropriate minimal duration of patient examination in the pulmonary practice.

    Methods: A total of 49 researchers from ten different study groups of the Turkish Thoracic Society participated in the study. Read More

    Predictive factors for a successful diagnostic bronchoscopy of ground-glass nodules.
    Ann Thorac Med 2017 Jul-Sep;12(3):171-176
    Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center Hospital, Tukiji Chou-ku, Japan.
    Introduction: Since the National Lung Screening Trial demonstrated the utility of low-dose computed tomography screening for lung cancer, the detection rate of ground-glass nodules (GGNs) has increased. Endobronchial ultrasound with a guide sheath (EBUS-GS) is widely performed to diagnose peripheral pulmonary lesions, but there are not enough reports on the predictive ability of EBUS-GS in diagnosing GGNs. The aim of this study is to investigate the predictive factors for a successful diagnostic bronchoscopy for GGNs. Read More

    Gaining access to the periphery of the lung: Bronchoscopic and transthoracic approaches.
    Ann Thorac Med 2017 Jul-Sep;12(3):162-170
    1st Department of Respiratory Medicine, National and Kapodistrian University of Athens, Athens, Greece.
    Globally, lung cancer remains the leading cause of cancer-related death. Annual low-dose computed tomography has been recommended as a screening test for early detection of lung cancers. Implementing this screening strategy is expected to challenge pulmonologist to confirm the nature of the increasing number of detected pulmonary nodules. Read More

    The Saudi Thoracic Society guidelines for diagnosis and management of noncystic fibrosis bronchiectasis.
    Ann Thorac Med 2017 Jul-Sep;12(3):135-161
    International Reviewer, Department of Pathophysiology and Transplantation, University of MilanInternal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Via Francesco Sforza 35, 20122, Milan, Italy.
    This is the first guideline developed by the Saudi Thoracic Society for the diagnosis and management of noncystic fibrosis bronchiectasis. Local experts including pulmonologists, infectious disease specialists, thoracic surgeons, respiratory therapists, and others from adult and pediatric departments provided the best practice evidence recommendations based on the available international and local literature. The main objective of this guideline is to utilize the current published evidence to develop recommendations about management of bronchiectasis suitable to our local health-care system and available resources. Read More

    Asthma-like attacks terminated by slow pathway ablation.
    Ann Thorac Med 2017 Apr-Jun;12(2):127-128
    Department of Cardiology, Private Yenisehir Hospital, Mersin, Turkey.
    Asthma is a chronic airway disease in which the pathological mechanisms are reversible airway obstruction, bronchial hyper reactivity, and constriction of the lower airways. Supraventricular tachycardia (SVT) is a common arrhythmia which originates above the bundle of His and causing heart rates exceeding 150 beats/min. SVT patients present with palpitation, chest pain, chest discomfort, dyspnea, hyperventilation, and lightheadedness, occasionally. Read More

    Simultaneous presentation of two noninflammatory lung diseases in an HIV-infected patient.
    Ann Thorac Med 2017 Apr-Jun;12(2):125-126
    Department of Family and Community Medicine, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid 28046, Spain.
    The simultaneous presentation of two noninflammatory pulmonary diseases, pulmonary alveolar proteinosis and Kaposi's sarcoma (Ks), in an HIV-infected patient, is described. A 29-year-old black race patient was admitted to the hospital because of general malaise, weight loss, dyspnea, chest pain, and cough with hemoptoic expectoration. Chest X-rays revealed a patchy bilateral alveolar pattern with a tendency toward the formation of condensations. Read More

    Pulmonary actinomycosis mimicking lung cancer on positron emission tomography.
    Ann Thorac Med 2017 Apr-Jun;12(2):121-124
    Department of Medicine, Samsung Medical Center, Division of Pulmonary and Critical Care Medicine, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Pulmonary actinomycosis frequently mimics lung malignancy on radiologic imaging studies. Positron emission tomography-computed tomography (PET-CT) is a useful diagnostic modality for differentiating lung malignancy from benign diseases. However, few studies evaluated PET-CT findings of pulmonary actinomycosis. Read More

    Endobronchial ultrasound plus fluoroscopy-guided biopsy compared to fluoroscopy-guided transbronchial biopsy for obtaining samples of peripheral pulmonary lesions: A systematic review and meta-analysis.
    Ann Thorac Med 2017 Apr-Jun;12(2):114-120
    Department of Pulmonary Medicine, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, China.
    Background: We report a meta-analysis of recent studies comparing the diagnostic yields of endobronchial ultrasonography plus fluoroscopically-guided transbronchial biopsy (EBUS + TBB) with that of conventional fluoroscopically-guided TBB for peripheral pulmonary lesions (PPLs).

    Methods: We searched Medline, the Cochrane Library, PubMed, and Google Scholar through 31 March 2013 using the keywords: lung neoplasm, pulmonary lesions, diagnosis, endobronchial ultrasound, fluoroscopy, and fluoroscopic.

    Results: Four studies were included in the study with a total of 461 patients, 222 in the EBUS + TBB group and 239 in the TBB only group. Read More

    Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea-hypopnea syndrome.
    Ann Thorac Med 2017 Apr-Jun;12(2):107-113
    Department of Basic Sciences, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
    Purpose: We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea-hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17).

    Methods: Ninety-two patients with severe OSAHS were consecutively enrolled between September 2014 and February 2016 and compared to age-, sex-, and body mass index (BMI)-matched controls. Anthropometric parameters and medical history were collected. Read More

    A study of chronic obstructive pulmonary disease-specific causes of osteoporosis with emphasis on the emphysema phenotype.
    Ann Thorac Med 2017 Apr-Jun;12(2):101-106
    Department of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Background: Osteoporosis, the most common extra-pulmonary complication of chronic obstructive pulmonary disease (COPD), may be related to general causes or COPD-specific causes such as low forced expiratory volume in 1 s (FEV1) and hypoxia. A few studies reported that emphysema is an independent risk factor for osteoporosis. However, other workers considered the association to be confounded by low FEV1 and low body mass index (BMI) which cluster with emphysema. Read More

    Systematic analysis of measurement variability in lung cancer with multidetector computed tomography.
    Ann Thorac Med 2017 Apr-Jun;12(2):95-100
    Department of Radiology, BenQ Medical Center, Nanjing Medical University, Nanjing, China.
    Objective: To systematically analyze the nature of measurement variability in lung cancer with multidetector computed tomography (CT) scans.

    Methods: Multidetector CT scans of 67 lung cancer patients were analyzed. Unidimensional (Response Evaluation Criteria in Solid Tumor criteria), bidimensional (World Health Organization criteria), and volumetric measurements were performed independently by ten radiologists and were repeated after at least 5 months. Read More

    Prevalence and risk factors of obstructive sleep apnea syndrome in a Saudi Arabian population.
    Ann Thorac Med 2017 Apr-Jun;12(2):88-94
    Sleep Disorders Center, King Abdulaziz Medical City, Ministry of National Guard, Jeddah, Saudi Arabia.
    Background: Obstructive sleep apnea (OSA) is a common disorder worldwide; however, epidemiological studies on its prevalence lack in Saudi Arabia. This study aimed to determine the prevalence and risk factors of OSA in Saudi Arabia.

    Methods: The study was performed from 2013 to 2015 in two stages. Read More

    Clinical and quality of life outcomes following anatomical lung resection for lung cancer in high-risk patients.
    Ann Thorac Med 2017 Apr-Jun;12(2):83-87
    Department of Thoracic Surgery, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.
    Background: Surgery remains the gold standard for patients with resectable nonsmall cell lung cancer. Current guidance identifies patients with poor pulmonary reserve to fall within a high-risk cohort. The aim of this study was to determine the clinical and quality of life outcomes of anatomical lung resection in patients deemed high risk based on pulmonary function measurements. Read More

    Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.
    Ann Thorac Med 2017 Apr-Jun;12(2):74-82
    Department of Clinical Pediatrics, Weill Cornell Medical College-Qtar, Doha, Qatar.
    Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that often occurs in patients with asthma or cystic fibrosis (CF) and is characterized by a hypersensitivity response to the allergens of the fungus Aspergillus fumigatus. In patients with CF, growth of A. fumigatus hyphae within the bronchial lumen triggers an immunoglobulin E (IgE)-mediated hypersensitivity response that results in airway inflammation, bronchospasm, and bronchiectasis. Read More

    A review of imaging modalities in pulmonary hypertension.
    Ann Thorac Med 2017 Apr-Jun;12(2):61-73
    Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
    Pulmonary hypertension (PH) is defined as resting mean pulmonary artery pressure ≥25 mmHg measured by right heart catheterization. PH is a progressive, life-threatening disease with a variety of etiologies. Swift and accurate diagnosis of PH and appropriate classification in etiologic group will allow for earlier treatment and improved outcomes. Read More

    Herceptin responsive lung adenocarcinoma in the setting of bilateral synchronous lung primaries and breast carcinoma.
    Ann Thorac Med 2017 Jan-Mar;12(1):57-58
    Department of Cardiothoracic Surgery, St. James's Hospital, Dublin, Ireland.
    The incidence of human epidermal growth factor receptor 2 (Her-2) mutations in lung adenocarcinoma is approximately 3%; however, its significance in the management of these lung cancers remains under investigation. We describe an incidental but unique opportunity to evaluate the response to treatment with herceptin in a patient with bilateral synchronous lung primaries in conjunction with breast carcinoma. Interval imaging following surgical resection of the squamous cell carcinoma while on herceptin treatment delineated the radiological regression of the Her-2 positive lung adenocarcinoma. Read More

    A foreign body reaction to Surgicel® in a lymph node diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration.
    Ann Thorac Med 2017 Jan-Mar;12(1):55-56
    Department of Pulmonology, Hospital del Mar-Parc de Salut Mar, UAB, CIBERES, ISCIII, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
    Surgicel® (Ethicon, North Ryde, NSW, Australia) is an absorbable sheet of oxidized cellulose polyanhydroglucuronic acid polymer used as an hemostatic in cardiovascular and thoracic surgery. In some cases, the retained material may cause foreign body granulomatous reactions and simulate tumor recurrence, an abscess, an hematoma, or an infection. We report the case of a 55-year-old patient who was operated of a lung adenocarcinoma. Read More

    A multifaceted approach to decrease inappropriate antibiotic use in a pediatric outpatient clinic.
    Ann Thorac Med 2017 Jan-Mar;12(1):51-54
    Department of Pediatric, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
    Background: Inappropriate use of antimicrobial agents is the major cause for the development of resistance. Thus, it is important to include outpatient clinics in the development of antibiotic stewardship program.

    Methods: We report a multifaceted approach to decrease inappropriate antibiotic use in upper respiratory tract infections (URTIs) in an outpatient pediatric clinic. Read More

    Anomalous systemic arterial supply of pulmonary sequestration in adult patients.
    Ann Thorac Med 2017 Jan-Mar;12(1):46-50
    Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
    Objectives: This study described the characteristics of the systemic arterial supply of pulmonary sequestration (PS) in an attempt to better distinguish PS from other acquired lesions.

    Methods: We identified 25 patients hospitalized at the Peking Union Medical College Hospital during January 2013 to December 2015 with the assistance of medical catalogers. Twenty-three patients with a definite diagnosis of "pulmonary sequestration" clinically or pathologically were included in the study. Read More

    Factors leading to refractory asthma in patients from Saudi Arabia.
    Ann Thorac Med 2017 Jan-Mar;12(1):42-45
    Department of Medicine, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
    Aim: The aim of this study was to study the clinical characteristic of patient with refractory asthma (RA) from Saudi Arabia.

    Methods: This paper prospectively studied in a university hospital factors leading to RA in a cohort of patients who have inadequately controlled asthma or with frequent exacerbations despite optimum controller therapy. It also studied patients with asthma that requires extended periods of oral steroids to control. Read More

    Association between thyroid cancer and epidermal growth factor receptor mutation in female with nonsmall cell lung cancer.
    Ann Thorac Med 2017 Jan-Mar;12(1):36-41
    Department of Internal Medicine, Division of Hematology/Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
    Background: The aim of this study was to investigate the association between epidermal growth factor receptor (EGFR) mutation and thyroid cancer in female patients with nonsmall-cell lung cancer (NSCLC).

    Methods: In a retrospective study, we examined 835 female patients who were diagnosed with NSCLC and underwent an EGFR mutation test between June 2003 and August 2013. The associations of EGFR mutation with thyroid cancer and a family history of thyroid cancer were evaluated using logistic regression models. Read More

    Factors determining altered perfusion after acute pulmonary embolism assessed by quantified single-photon emission computed tomography-perfusion scan.
    Ann Thorac Med 2017 Jan-Mar;12(1):30-35
    Department of Medicine, Respiratory Division, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
    Aim Of The Study: The aim of the study was to analyze the evolution of perfusion (Q)-defects in patients treated for acute pulmonary embolism (PE), correlation with baseline parameters and evaluation of recurrence risk.

    Methods: This is a single-center prospective observational cohort study in symptomatic normotensive PE. Comparison of the ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT) acquired at baseline with a quantified SPECT (Q-SPECT) repeated at 1 week and 6 months. Read More

    Polysomnographic findings in infants with Pierre Robin sequence.
    Ann Thorac Med 2017 Jan-Mar;12(1):25-29
    Department of Pediatrics, University of Toronto, Ontario, Canada; Department of Pediatrics, Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
    Introduction: Pierre Robin sequence (PRS) is characterized by the triad of micrognathia, glossoptosis, and upper airway obstruction. It is commonly associated with the secondary cleft palate. Infants with PRS commonly have sleep-disordered breathing (SDB); including obstructive sleep apnea (OSA) as well as central sleep breathing abnormalities that are present from infancy. Read More

    The effect of demographics and patient location on the outcome of patients with acute respiratory distress syndrome.
    Ann Thorac Med 2017 Jan-Mar;12(1):17-24
    Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
    Objective: Outcome of acute respiratory distress syndrome (ARDS) in relation to age, gender, race, pre-Intensive Care Unit (ICU) location, and type of ICU.

    Methods: Retrospective cohort study of patients enrolled in the ARDS network randomized controlled trials.

    Results: A total of 2914 patients were included in these trials. Read More

    Introducing the Comprehensive Unit-based Safety Program for mechanically ventilated patients in Saudi Arabian Intensive Care Units.
    Ann Thorac Med 2017 Jan-Mar;12(1):11-16
    Department of Intensive Care, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
    Over the past decade, there have been major improvements to the care of mechanically ventilated patients (MVPs). Earlier initiatives used the concept of ventilator care bundles (sets of interventions), with a primary focus on reducing ventilator-associated pneumonia. However, recent evidence has led to a more comprehensive approach: The ABCDE bundle (Awakening and Breathing trial Coordination, Delirium management and Early mobilization). Read More

    Pleural procedures in the management of malignant effusions.
    Ann Thorac Med 2017 Jan-Mar;12(1):3-10
    Department of Pulmonology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain; Interdisciplinary Research Group in Pulmonology, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
    Malignant pleural effusion (MPE) is common in clinical practice, and despite the existence of studies to guide clinical decisions, it often poses diagnostic and therapeutic dilemmas. Once it is diagnosed, median survival does not usually exceed 6 months. The management of these patients focuses on symptom relief since no treatments have been shown to increase survival to date. Read More

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