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    573 results match your criteria Annals of Thoracic Medicine [Journal]

    1 OF 12

    Prevalence of antibodies against the Middle East Respiratory Syndrome coronavirus, influenza A and B viruses among blood donors, Saudi Arabia.
    Ann Thorac Med 2017 Jul-Sep;12(3):217-218
    Department of Intensive Care, College of Medicine, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia E-mail:

    The most frequent ABCA3 nonsense mutation -p.Tyr1515* (Y1515X) causing lethal neonatal respiratory failure in a term neonate.
    Ann Thorac Med 2017 Jul-Sep;12(3):213-215
    Genetic Department, Henri Mondor Hospital, France.
    Defects in the surfactant biosynthesis are associated with respiratory distress syndrome, commonly occurring in premature infants due to lung immaturity. However, interstitial lung diseases have also been observed in full-term infants with mutations in the SFTPC, SFTPB, NKX2-1, or ABCA3 genes, involved in the surfactant metabolism. Herein, we report a newborn baby with neonatal respiratory distress and diffuse lung disease caused by ABCA3 mutation. Read More

    Severe fibrosing mediastinitis with atypical presentation: Effective control with novel therapeutic approach.
    Ann Thorac Med 2017 Jul-Sep;12(3):209-212
    Department of Cardiac Sciences, King Khalid University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Fibrosing mediastinitis (FM), also known as sclerosing mediastinitis, is an uncommon but serious disease involving the mediastinal structures. A high index of suspicion is essential to establish the diagnosis of FM and starting the appropriate therapy for patients. Here, we report a case of a young female who presented with chest symptoms and subsequently underwent different laboratory and radiologic investigations and an excisional biopsy. Read More

    Pulmonary consequences of hypothyroidism.
    Ann Thorac Med 2017 Jul-Sep;12(3):204-208
    Department of Chest, Faculty of Medicine, Assiut University Hospital, Assuit, Egypt.
    Background: Although hypothyroidism has an insidious onset and relatively asymptomatic, exertional dyspnea and fatigue can be the presenting complaints.

    Objectives: The aim is to assess functional lung impairment in hypothyroid patients both at rest and during exercise.

    Methods: A case-control study was carried out on 42 patients with newly diagnosed hypothyroidism and 12 control subjects. Read More

    Assessment of anti-factor Xa activity of enoxaparin for venous thromboembolism prophylaxis in morbidly obese surgical patients.
    Ann Thorac Med 2017 Jul-Sep;12(3):199-203
    Department of Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
    Background: Venous thromboembolism (VTE) can be encountered by 60% of hospitalized patients. Anticoagulants have been recommended to reduce the risk of VTE in patients with risk factors. However, no specific dosing recommendations for obese patients are provided in the current practice guidelines. Read More

    Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: An autopsy study.
    Ann Thorac Med 2017 Jul-Sep;12(3):191-198
    Institute of Pathology, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
    Introduction: Lung cancer is among leading causes of death worldwide. Different histological types of the lung carcinoma show significant differences in behavior.

    Objectives: The aim of this study is to determine the distribution patterns of metastases of different lung cancer histological types in autopsied individuals. Read More

    The influence of intermittent fasting on the circadian pattern of melatonin while controlling for caloric intake, energy expenditure, light exposure, and sleep schedules: A preliminary report.
    Ann Thorac Med 2017 Jul-Sep;12(3):183-190
    Department of Physiology, King Saud University, Riyadh, Saudi Arabia.
    Aims: We hypothesized that if we control for food composition, caloric intake, light exposure, sleep schedule, and exercise, intermittent fasting would not influence the circadian pattern of melatonin. Therefore, we designed this study to assess the effect of intermittent fasting on the circadian pattern of melatonin.

    Methods: Eight healthy volunteers with a mean age of 26. Read More

    What should be the appropriate minimal duration for patient examination and evaluation in pulmonary outpatient clinics?
    Ann Thorac Med 2017 Jul-Sep;12(3):177-182
    Celal Bayar University Medical Faculty, Department of Chest Diseases, Manisa, Turkey.
    Introduction: Patient examinations performed in a limited time period may lead to impairment in patient and physician relationship, defective and erroneous diagnosis, inappropriate prescriptions, less common use of preventive medicine practices, poor patient satisfaction, and increased violent acts against health-care staff.

    Objective: This study aimed to determine the appropriate minimal duration of patient examination in the pulmonary practice.

    Methods: A total of 49 researchers from ten different study groups of the Turkish Thoracic Society participated in the study. Read More

    Predictive factors for a successful diagnostic bronchoscopy of ground-glass nodules.
    Ann Thorac Med 2017 Jul-Sep;12(3):171-176
    Department of Endoscopy, Respiratory Endoscopy Division, National Cancer Center Hospital, Tukiji Chou-ku, Japan.
    Introduction: Since the National Lung Screening Trial demonstrated the utility of low-dose computed tomography screening for lung cancer, the detection rate of ground-glass nodules (GGNs) has increased. Endobronchial ultrasound with a guide sheath (EBUS-GS) is widely performed to diagnose peripheral pulmonary lesions, but there are not enough reports on the predictive ability of EBUS-GS in diagnosing GGNs. The aim of this study is to investigate the predictive factors for a successful diagnostic bronchoscopy for GGNs. Read More

    Gaining access to the periphery of the lung: Bronchoscopic and transthoracic approaches.
    Ann Thorac Med 2017 Jul-Sep;12(3):162-170
    1st Department of Respiratory Medicine, National and Kapodistrian University of Athens, Athens, Greece.
    Globally, lung cancer remains the leading cause of cancer-related death. Annual low-dose computed tomography has been recommended as a screening test for early detection of lung cancers. Implementing this screening strategy is expected to challenge pulmonologist to confirm the nature of the increasing number of detected pulmonary nodules. Read More

    The Saudi Thoracic Society guidelines for diagnosis and management of noncystic fibrosis bronchiectasis.
    Ann Thorac Med 2017 Jul-Sep;12(3):135-161
    International Reviewer, Department of Pathophysiology and Transplantation, University of MilanInternal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Via Francesco Sforza 35, 20122, Milan, Italy.
    This is the first guideline developed by the Saudi Thoracic Society for the diagnosis and management of noncystic fibrosis bronchiectasis. Local experts including pulmonologists, infectious disease specialists, thoracic surgeons, respiratory therapists, and others from adult and pediatric departments provided the best practice evidence recommendations based on the available international and local literature. The main objective of this guideline is to utilize the current published evidence to develop recommendations about management of bronchiectasis suitable to our local health-care system and available resources. Read More

    Asthma-like attacks terminated by slow pathway ablation.
    Ann Thorac Med 2017 Apr-Jun;12(2):127-128
    Department of Cardiology, Private Yenisehir Hospital, Mersin, Turkey.
    Asthma is a chronic airway disease in which the pathological mechanisms are reversible airway obstruction, bronchial hyper reactivity, and constriction of the lower airways. Supraventricular tachycardia (SVT) is a common arrhythmia which originates above the bundle of His and causing heart rates exceeding 150 beats/min. SVT patients present with palpitation, chest pain, chest discomfort, dyspnea, hyperventilation, and lightheadedness, occasionally. Read More

    Simultaneous presentation of two noninflammatory lung diseases in an HIV-infected patient.
    Ann Thorac Med 2017 Apr-Jun;12(2):125-126
    Department of Family and Community Medicine, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid 28046, Spain.
    The simultaneous presentation of two noninflammatory pulmonary diseases, pulmonary alveolar proteinosis and Kaposi's sarcoma (Ks), in an HIV-infected patient, is described. A 29-year-old black race patient was admitted to the hospital because of general malaise, weight loss, dyspnea, chest pain, and cough with hemoptoic expectoration. Chest X-rays revealed a patchy bilateral alveolar pattern with a tendency toward the formation of condensations. Read More

    Pulmonary actinomycosis mimicking lung cancer on positron emission tomography.
    Ann Thorac Med 2017 Apr-Jun;12(2):121-124
    Department of Medicine, Samsung Medical Center, Division of Pulmonary and Critical Care Medicine, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Pulmonary actinomycosis frequently mimics lung malignancy on radiologic imaging studies. Positron emission tomography-computed tomography (PET-CT) is a useful diagnostic modality for differentiating lung malignancy from benign diseases. However, few studies evaluated PET-CT findings of pulmonary actinomycosis. Read More

    Endobronchial ultrasound plus fluoroscopy-guided biopsy compared to fluoroscopy-guided transbronchial biopsy for obtaining samples of peripheral pulmonary lesions: A systematic review and meta-analysis.
    Ann Thorac Med 2017 Apr-Jun;12(2):114-120
    Department of Pulmonary Medicine, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, China.
    Background: We report a meta-analysis of recent studies comparing the diagnostic yields of endobronchial ultrasonography plus fluoroscopically-guided transbronchial biopsy (EBUS + TBB) with that of conventional fluoroscopically-guided TBB for peripheral pulmonary lesions (PPLs).

    Methods: We searched Medline, the Cochrane Library, PubMed, and Google Scholar through 31 March 2013 using the keywords: lung neoplasm, pulmonary lesions, diagnosis, endobronchial ultrasound, fluoroscopy, and fluoroscopic.

    Results: Four studies were included in the study with a total of 461 patients, 222 in the EBUS + TBB group and 239 in the TBB only group. Read More

    Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea-hypopnea syndrome.
    Ann Thorac Med 2017 Apr-Jun;12(2):107-113
    Department of Basic Sciences, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
    Purpose: We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea-hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17).

    Methods: Ninety-two patients with severe OSAHS were consecutively enrolled between September 2014 and February 2016 and compared to age-, sex-, and body mass index (BMI)-matched controls. Anthropometric parameters and medical history were collected. Read More

    A study of chronic obstructive pulmonary disease-specific causes of osteoporosis with emphasis on the emphysema phenotype.
    Ann Thorac Med 2017 Apr-Jun;12(2):101-106
    Department of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Background: Osteoporosis, the most common extra-pulmonary complication of chronic obstructive pulmonary disease (COPD), may be related to general causes or COPD-specific causes such as low forced expiratory volume in 1 s (FEV1) and hypoxia. A few studies reported that emphysema is an independent risk factor for osteoporosis. However, other workers considered the association to be confounded by low FEV1 and low body mass index (BMI) which cluster with emphysema. Read More

    Systematic analysis of measurement variability in lung cancer with multidetector computed tomography.
    Ann Thorac Med 2017 Apr-Jun;12(2):95-100
    Department of Radiology, BenQ Medical Center, Nanjing Medical University, Nanjing, China.
    Objective: To systematically analyze the nature of measurement variability in lung cancer with multidetector computed tomography (CT) scans.

    Methods: Multidetector CT scans of 67 lung cancer patients were analyzed. Unidimensional (Response Evaluation Criteria in Solid Tumor criteria), bidimensional (World Health Organization criteria), and volumetric measurements were performed independently by ten radiologists and were repeated after at least 5 months. Read More

    Prevalence and risk factors of obstructive sleep apnea syndrome in a Saudi Arabian population.
    Ann Thorac Med 2017 Apr-Jun;12(2):88-94
    Sleep Disorders Center, King Abdulaziz Medical City, Ministry of National Guard, Jeddah, Saudi Arabia.
    Background: Obstructive sleep apnea (OSA) is a common disorder worldwide; however, epidemiological studies on its prevalence lack in Saudi Arabia. This study aimed to determine the prevalence and risk factors of OSA in Saudi Arabia.

    Methods: The study was performed from 2013 to 2015 in two stages. Read More

    Clinical and quality of life outcomes following anatomical lung resection for lung cancer in high-risk patients.
    Ann Thorac Med 2017 Apr-Jun;12(2):83-87
    Department of Thoracic Surgery, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.
    Background: Surgery remains the gold standard for patients with resectable nonsmall cell lung cancer. Current guidance identifies patients with poor pulmonary reserve to fall within a high-risk cohort. The aim of this study was to determine the clinical and quality of life outcomes of anatomical lung resection in patients deemed high risk based on pulmonary function measurements. Read More

    Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.
    Ann Thorac Med 2017 Apr-Jun;12(2):74-82
    Department of Clinical Pediatrics, Weill Cornell Medical College-Qtar, Doha, Qatar.
    Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that often occurs in patients with asthma or cystic fibrosis (CF) and is characterized by a hypersensitivity response to the allergens of the fungus Aspergillus fumigatus. In patients with CF, growth of A. fumigatus hyphae within the bronchial lumen triggers an immunoglobulin E (IgE)-mediated hypersensitivity response that results in airway inflammation, bronchospasm, and bronchiectasis. Read More

    A review of imaging modalities in pulmonary hypertension.
    Ann Thorac Med 2017 Apr-Jun;12(2):61-73
    Department of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH, USA.
    Pulmonary hypertension (PH) is defined as resting mean pulmonary artery pressure ≥25 mmHg measured by right heart catheterization. PH is a progressive, life-threatening disease with a variety of etiologies. Swift and accurate diagnosis of PH and appropriate classification in etiologic group will allow for earlier treatment and improved outcomes. Read More

    Herceptin responsive lung adenocarcinoma in the setting of bilateral synchronous lung primaries and breast carcinoma.
    Ann Thorac Med 2017 Jan-Mar;12(1):57-58
    Department of Cardiothoracic Surgery, St. James's Hospital, Dublin, Ireland.
    The incidence of human epidermal growth factor receptor 2 (Her-2) mutations in lung adenocarcinoma is approximately 3%; however, its significance in the management of these lung cancers remains under investigation. We describe an incidental but unique opportunity to evaluate the response to treatment with herceptin in a patient with bilateral synchronous lung primaries in conjunction with breast carcinoma. Interval imaging following surgical resection of the squamous cell carcinoma while on herceptin treatment delineated the radiological regression of the Her-2 positive lung adenocarcinoma. Read More

    A foreign body reaction to Surgicel(®) in a lymph node diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration.
    Ann Thorac Med 2017 Jan-Mar;12(1):55-56
    Department of Pulmonology, Hospital del Mar-Parc de Salut Mar, UAB, CIBERES, ISCIII, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
    Surgicel(®) (Ethicon, North Ryde, NSW, Australia) is an absorbable sheet of oxidized cellulose polyanhydroglucuronic acid polymer used as an hemostatic in cardiovascular and thoracic surgery. In some cases, the retained material may cause foreign body granulomatous reactions and simulate tumor recurrence, an abscess, an hematoma, or an infection. We report the case of a 55-year-old patient who was operated of a lung adenocarcinoma. Read More

    A multifaceted approach to decrease inappropriate antibiotic use in a pediatric outpatient clinic.
    Ann Thorac Med 2017 Jan-Mar;12(1):51-54
    Department of Pediatric, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
    Background: Inappropriate use of antimicrobial agents is the major cause for the development of resistance. Thus, it is important to include outpatient clinics in the development of antibiotic stewardship program.

    Methods: We report a multifaceted approach to decrease inappropriate antibiotic use in upper respiratory tract infections (URTIs) in an outpatient pediatric clinic. Read More

    Anomalous systemic arterial supply of pulmonary sequestration in adult patients.
    Ann Thorac Med 2017 Jan-Mar;12(1):46-50
    Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
    Objectives: This study described the characteristics of the systemic arterial supply of pulmonary sequestration (PS) in an attempt to better distinguish PS from other acquired lesions.

    Methods: We identified 25 patients hospitalized at the Peking Union Medical College Hospital during January 2013 to December 2015 with the assistance of medical catalogers. Twenty-three patients with a definite diagnosis of "pulmonary sequestration" clinically or pathologically were included in the study. Read More

    Factors leading to refractory asthma in patients from Saudi Arabia.
    Ann Thorac Med 2017 Jan-Mar;12(1):42-45
    Department of Medicine, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
    Aim: The aim of this study was to study the clinical characteristic of patient with refractory asthma (RA) from Saudi Arabia.

    Methods: This paper prospectively studied in a university hospital factors leading to RA in a cohort of patients who have inadequately controlled asthma or with frequent exacerbations despite optimum controller therapy. It also studied patients with asthma that requires extended periods of oral steroids to control. Read More

    Association between thyroid cancer and epidermal growth factor receptor mutation in female with nonsmall cell lung cancer.
    Ann Thorac Med 2017 Jan-Mar;12(1):36-41
    Department of Internal Medicine, Division of Hematology/Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
    Background: The aim of this study was to investigate the association between epidermal growth factor receptor (EGFR) mutation and thyroid cancer in female patients with nonsmall-cell lung cancer (NSCLC).

    Methods: In a retrospective study, we examined 835 female patients who were diagnosed with NSCLC and underwent an EGFR mutation test between June 2003 and August 2013. The associations of EGFR mutation with thyroid cancer and a family history of thyroid cancer were evaluated using logistic regression models. Read More

    Factors determining altered perfusion after acute pulmonary embolism assessed by quantified single-photon emission computed tomography-perfusion scan.
    Ann Thorac Med 2017 Jan-Mar;12(1):30-35
    Department of Medicine, Respiratory Division, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
    Aim Of The Study: The aim of the study was to analyze the evolution of perfusion (Q)-defects in patients treated for acute pulmonary embolism (PE), correlation with baseline parameters and evaluation of recurrence risk.

    Methods: This is a single-center prospective observational cohort study in symptomatic normotensive PE. Comparison of the ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT) acquired at baseline with a quantified SPECT (Q-SPECT) repeated at 1 week and 6 months. Read More

    Polysomnographic findings in infants with Pierre Robin sequence.
    Ann Thorac Med 2017 Jan-Mar;12(1):25-29
    Department of Pediatrics, University of Toronto, Ontario, Canada; Department of Pediatrics, Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
    Introduction: Pierre Robin sequence (PRS) is characterized by the triad of micrognathia, glossoptosis, and upper airway obstruction. It is commonly associated with the secondary cleft palate. Infants with PRS commonly have sleep-disordered breathing (SDB); including obstructive sleep apnea (OSA) as well as central sleep breathing abnormalities that are present from infancy. Read More

    The effect of demographics and patient location on the outcome of patients with acute respiratory distress syndrome.
    Ann Thorac Med 2017 Jan-Mar;12(1):17-24
    Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
    Objective: Outcome of acute respiratory distress syndrome (ARDS) in relation to age, gender, race, pre-Intensive Care Unit (ICU) location, and type of ICU.

    Methods: Retrospective cohort study of patients enrolled in the ARDS network randomized controlled trials.

    Results: A total of 2914 patients were included in these trials. Read More

    Introducing the Comprehensive Unit-based Safety Program for mechanically ventilated patients in Saudi Arabian Intensive Care Units.
    Ann Thorac Med 2017 Jan-Mar;12(1):11-16
    Department of Intensive Care, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
    Over the past decade, there have been major improvements to the care of mechanically ventilated patients (MVPs). Earlier initiatives used the concept of ventilator care bundles (sets of interventions), with a primary focus on reducing ventilator-associated pneumonia. However, recent evidence has led to a more comprehensive approach: The ABCDE bundle (Awakening and Breathing trial Coordination, Delirium management and Early mobilization). Read More

    Pleural procedures in the management of malignant effusions.
    Ann Thorac Med 2017 Jan-Mar;12(1):3-10
    Department of Pulmonology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain; Interdisciplinary Research Group in Pulmonology, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
    Malignant pleural effusion (MPE) is common in clinical practice, and despite the existence of studies to guide clinical decisions, it often poses diagnostic and therapeutic dilemmas. Once it is diagnosed, median survival does not usually exceed 6 months. The management of these patients focuses on symptom relief since no treatments have been shown to increase survival to date. Read More

    Aspiration-related organizing pneumonia complicating laparoscopic adjustable gastric banding: A lung cancer mimicker.
    Ann Thorac Med 2016 Oct-Dec;11(4):294-296
    Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    There are several described pulmonary complications due to laparoscopic adjustable gastric banding. We report a rare case of a 32-year-old male who presented with pulmonary symptoms and a solitary lung mass 12 years after laparoscopic adjustable gastric banding. A bronchoscopic lung biopsy showed organizing pneumonia that was induced by aspiration pneumonia. Read More

    Dasatinib-induced pleural effusion: Chylothorax, an option to consider.
    Ann Thorac Med 2016 Oct-Dec;11(4):289-293
    Department of Pulmonology, University Clinical Hospital of Santiago de Compostela, A Coruña, Spain; Department of Interdisciplinary Research Group in Pulmonology, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, A Coruña, Spain.
    Dasatinib is a drug for treatment of oncogene fusion protein BCR-ABL-positive chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant/intolerant to imatinib. Pleural effusion (PE) is a common adverse effect, and in this context, we present four cases seen due to this cause. One of them is a chylothorax. Read More

    Ketamine versus aminophylline for acute asthma in children: A randomized, controlled trial.
    Ann Thorac Med 2016 Oct-Dec;11(4):283-288
    Department of Pediatrics, Government Medical College Hospital, Chandigarh, India; Department of Pediatrics, All Institute of Medical Sciences, New Delhi, India.
    Background: There is a lack of consensus regarding second-line therapy in children with acute asthma who fail to the standard therapy. Ketamine had bronchodilator property and may be useful in the treatment of acute asthma.

    Objective: The objective of this study was to evaluate the efficacy and safety of ketamine as compared to aminophylline in children with acute asthma who respond poorly to the standard therapy. Read More

    The diagnostic significance of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 levels in pulmonary embolism.
    Ann Thorac Med 2016 Oct-Dec;11(4):277-282
    Department of Chest Diseases, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
    Background: Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Patients with PE often have nonspecific symptoms, and the diagnosis is often delayed.

    Aim: The aim of our study was to investigate the role of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) used in the diagnosis of PE. Read More

    Diagnostic implications of computed tomography pulmonary angiography in patients with pulmonary embolism.
    Ann Thorac Med 2016 Oct-Dec;11(4):269-276
    Department of Surgery, Vascular Surgery, Hamad General Hospital, Doha, Qatar.
    Introduction: Pulmonary embolism (PE) is a serious cardiovascular and pulmonary complication worldwide. We aimed to assess the implications of different computed tomography pulmonary angiography (CTPA) parameters in patients with acute PE.

    Methods: A retrospective observational study to include patients presented with clinical suspicious of PE who underwent CTPA was conducted. Read More

    Body mass index, airflow obstruction and dyspnea and body mass index, airflow obstruction, dyspnea scores, age and pack years-predictive properties of new multidimensional prognostic indices of chronic obstructive pulmonary disease in primary care.
    Ann Thorac Med 2016 Oct-Dec;11(4):261-268
    Department of Respiratory Care, College of Applied Medical Sciences, University of Dammam, Dammam, Kingdom of Saudi Arabia.
    Background: The assessment of the severity of chronic obstructive pulmonary disease (COPD) should involve a multidimensional approach that is now clearly shown to be better than using spirometric impairment alone. The aim of this study is to validate and compare novel tools without an exercise test and to extend prognostic value to patients with less severe impairment of Forced expiratory volume 1 s.

    Methods: A prospective, observational, primary care cohort study identified 458 eligible patients recruited from the primary care clinics in the northeast of England in 1999-2002. Read More

    Suboptimal implementation of diagnostic algorithms and overuse of computed tomography-pulmonary angiography in patients with suspected pulmonary embolism.
    Ann Thorac Med 2016 Oct-Dec;11(4):254-260
    Division of Pulmonary and Critical Care Medicine, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.
    Background: Majority of our computed tomography-pulmonary angiography (CTPA) scans report negative findings. We hypothesized that suboptimal reliance on diagnostic algorithms contributes to apparent overuse of this test.

    Methods: A retrospective review was performed on 2031 CTPA cases in a large hospital system. Read More

    Alterations of pulmonary function in patients with inflammatory bowel diseases.
    Ann Thorac Med 2016 Oct-Dec;11(4):249-253
    Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Jinan 250014, Shandong Province, China.
    Aim: The aim of this study was to investigate the alterations of pulmonary function tests (PFTs) and their relationship with disease activity in inflammatory bowel diseases (IBDs).

    Methods: Sixty-four IBD patients (31 Crohn's disease [CD] and 33 ulcerative colitis [UC]) and thirty healthy individuals (controls) were studied with regard to the following parameters of PFTs: Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), their ratio, mid-forced expiratory flow of 25-75% (FEF 25-75), residual volume, total lung capacity, and diffusing capacity of the lung for carbon monoxide (DLCO). The disease activity was calculated using the Crohn's Disease Activity Index for CD and Mayo Clinic Score for UC. Read More

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