Ann Plast Surg 2017 Sep 19. Epub 2017 Sep 19.
From the *Department of Dermatology, University of California Davis, Sacramento, CA; †Craniofacial Research Laboratory, Section of Plastic Surgery, University of Michigan, Ann Arbor, MI; ‡Division of Plastic and Reconstructive Surgery, St Louis University School of Medicine, St Louis, MO; §Division of Plastic & Reconstructive Surgery, Baylor College of Medicine, Houston, TX; ∥Podiatry Section, Department of Surgery, VA Northern California Health Care Systems, Mather, CA; ¶Orthopedic Research Laboratory, Department of Orthopedic Surgery, University of Michigan; and #Pediatric Plastic Surgery Section, University of Michigan Medical School, Ann Arbor, MI.
: Using distraction osteogenesis (DO) to regenerate robust endogenous bone could greatly enhance postoncologic reconstruction of head and neck cancer. However, radiation (XRT) corrosive effects still preclude DO's immense potential. We posit that adjunctive pretreatment with the radioprotectant amifostine (AMF) can optimize wound healing and allow for successful DO with quantifiable enhancements in bony union and strength despite previous surgical bed irradiation. Read More