2,469 results match your criteria Annals of Nutrition and Metabolism[Journal]


Fetuin-B Links Nonalcoholic Fatty Liver Disease to Chronic Kidney Disease in Obese Chinese Adults: A Cross-Sectional Study.

Ann Nutr Metab 2019 Apr 9;74(4):287-295. Epub 2019 Apr 9.

Xiamen Diabetes Institute, The First Affiliated Hospital, Xiamen University, Xiamen, China,

Background: There is no evidence available on the association of Fetuin-B with chronic kidney disease (CKD), and mechanisms linking nonalcoholic fatty liver disease (NAFLD) to CKD are not fully understood. We aimed to explore the independent associations and potential mechanisms of Fetuin-B and NAFLD with CKD.

Methods: A cross-sectional study of 1,072 Chinese adults who underwent serum Fetuin-B test and hepatic ultrasonography scanning was conducted in Xiamen, China. Read More

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http://dx.doi.org/10.1159/000499843DOI Listing
April 2019
1 Read

Impact of Micronutrient Status during Pregnancy on Early Nutrition Programming.

Ann Nutr Metab 2019 Apr 2;74(4):269-278. Epub 2019 Apr 2.

LMU, Ludwig-Maximilians-Universität Munich, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.

Background: Nutrition status prior to conception and during pregnancy and infancy seems to have an influence on the disease risk in adulthood (early nutrition/developmental programming). We aimed to review the current knowledge on the role of micronutrients in early nutrition programming and its implications for healthcare.

Summary Of Findings: Globally and even in high-income countries where a balanced diet is generally accessible, an inadequate maternal micronutrient status is common. Read More

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http://dx.doi.org/10.1159/000499698DOI Listing

MicroRNA-496 and Mechanistic Target of Rapamycin Expression are Associated with Type 2 Diabetes Mellitus and Obesity in Elderly People.

Ann Nutr Metab 2019 Apr 2;74(4):279-286. Epub 2019 Apr 2.

Department of General, Visceral, Vascular, and Pediatric Surgery, University of Saarland Medical Center, Homburg, Germany.

Background: Mechanistic target of rapamycin (mTOR) regulates lipid and glucose metabolism thus playing a key role in metabolic diseases like type 2 diabetes mellitus (T2DM). Recently, we demonstrated a functional interaction of microRNA-496 (miR-496) with mTOR and its impact on the regulation of human ageing.

Objectives: As T2DM is most prevalent in older adults, we hypothesized that miR-496 may also have an impact on mTOR regulation in T2DM. Read More

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http://dx.doi.org/10.1159/000499576DOI Listing
April 2019
2 Reads

Correlation between Methylenetetrahydrofolate Reductase Polymorphisms and Hepatocellular Carcinoma: A Meta-Analysis.

Ann Nutr Metab 2019 27;74(3):251-256. Epub 2019 Mar 27.

Gastrointestinal Surgery, Tengzhou Central People's Hospital, Zaozhuang, China,

Background: The correlation between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and hepatocellular carcinoma (HCC) remains controversial.

Objectives: We performed this study to better assess the relationship between MTHFR gene polymorphisms and the likelihood of HCC.

Methods: A systematic research of PubMed, Medline, and Embase was performed to retrieve relevant articles. Read More

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http://dx.doi.org/10.1159/000496428DOI Listing

Decreased Amino Acid Concentrations are Involved in Congenital Heart Disease.

Ann Nutr Metab 2019 27;74(3):257-263. Epub 2019 Mar 27.

Department of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, China,

Objective: Congenital heart disease (CHD) is the most common malformation in China. In this study, we determined whether amino acids (AAs) in the amniotic fluid (AF) of patients with CHD changed and clarified whether AAs would affect the insulin-like growth factor type 1 receptor (IGF1R).

Method: Fifty-seven AF samples from pregnant women carrying CHD-affected (n = 17) or normal (n = 40) fetuses were collected. Read More

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https://www.karger.com/Article/FullText/499405
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http://dx.doi.org/10.1159/000499405DOI Listing
March 2019
4 Reads

Erratum.

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Ann Nutr Metab 2019 27;74(3):264. Epub 2019 Mar 27.

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http://dx.doi.org/10.1159/000499460DOI Listing

Revised Reference Values for the Intake of Protein.

Ann Nutr Metab 2019 22;74(3):242-250. Epub 2019 Mar 22.

Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany.

Background: Following a timely update process, the nutrition societies of Germany, Austria, and Switzerland (D-A-CH) revised the reference values for the intake of protein in 2017. The Working Group conducted a structured literature search in PubMed considering newly published papers (2000- 2017).

Summary: For infants < 4 months, the estimated values were set based on the protein intake via breast milk. Read More

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http://dx.doi.org/10.1159/000499374DOI Listing

Is Waist-to-Height Ratio Superior to Body Mass Index and Waist Circumference in Predicting the Incidence of Hypertension?

Ann Nutr Metab 2019 19;74(3):215-223. Epub 2019 Mar 19.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Background: It is still controversial which anthropometric indicator could be the best predictor of the incident hypertension.

Objectives: To examine the relative power of body mass index (BMI), waist circumference (WC), skinfold thickness, waist-to-hip ratio (WHR), and waist-to-height ratio (WHTR) in predicting the incidence of hypertension in Chinese adults.

Method: Data were obtained from the China Health and Nutrition Survey. Read More

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http://dx.doi.org/10.1159/000499073DOI Listing
March 2019
1 Read

Probiotic Foods and Supplements Interventions for Metabolic Syndromes: A Systematic Review and Meta-Analysis of Recent Clinical Trials.

Ann Nutr Metab 2019 19;74(3):224-241. Epub 2019 Mar 19.

William Preston Turner School of Nursing, Lander University, Greenwood, South Carolina, USA.

Background: Individual clinical trials suggested that when treated with probiotic foods or supplements with Lactobacillus and Bifidobacterium, specific symptoms of metabolic syndrome (MetS) could be alleviated, but the results have been inconclusive.

Aims: The objective of the present meta-analysis was to use anthropometric and biochemical as indicators to evaluate the efficacy of using these probiotic foods or supplements among individuals with MetS.

Methods: PubMed, Cochrane Library, and CINAHL Plus were used to collect randomized controlled trials (RCTs) studies published from January 2000 to January 2018. Read More

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http://dx.doi.org/10.1159/000499028DOI Listing
March 2019
1 Read

Circulating Iron Levels Interaction with Central Obesity on the Risk of Nonalcoholic Fatty Liver Disease: A Case-Control Study in Southeast China.

Ann Nutr Metab 2019 14;74(3):207-214. Epub 2019 Mar 14.

Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China,

Objectives: We aimed to evaluate the associations between body iron stores and the risk of nonalcoholic fatty liver disease (NAFLD) in a Chinese population and explore whether this effect may be modified by other factors.

Methods: A 1: 1 frequency-matched case-control study was conducted, including 482 NAFLD cases and 490 gender- and age-matched controls. Serum levels of ferritin, hepcidin, and C-reactive protein were measured. Read More

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http://dx.doi.org/10.1159/000497228DOI Listing
March 2019
3 Reads

Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population.

Ann Nutr Metab 2019 27;74(3):200-206. Epub 2019 Feb 27.

College of Medicine and Forensic, Health Science Center, Xi'an Jiao Tong University, Xi'an, China,

Some effective antithyroid drugs (ATDs) have been widely used for patients with Graves' disease (GD) but are associated with ATD-induced agranulocytosis. We selected 29 ATD-induced agranulocytosis patients, 44 ATD-induced neutropenia patients, and 140 GD controls among the Chinese Han population who were recruited at the First Affiliated Hospital of Xi'an Jiao Tong University. We assessed their response to ATDs treatment by performing genotyping for a candidate gene association study of samples from patients receiving treatment. Read More

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http://dx.doi.org/10.1159/000497314DOI Listing
February 2019
2 Reads

IUNS News.

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Ann Nutr Metab 2019 25;74(2):177-179. Epub 2019 Feb 25.

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http://dx.doi.org/10.1159/000498879DOI Listing
February 2019

FENS News.

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Ann Nutr Metab 2019 25;74(2):180. Epub 2019 Feb 25.

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http://dx.doi.org/10.1159/000498880DOI Listing
February 2019

Accelerated Weight Gain Subsequent to Postnatal Slow Weight Gain and Overweight Risk in Early Childhood: A Nested Case-Control Study.

Authors:
Izumi Akaboshi

Ann Nutr Metab 2019 21;74(3):181-188. Epub 2019 Feb 21.

Akaboshi Pediatric Clinic, Kumamoto City Medical Association, Kumamoto, Japan,

Background: The effects of accelerated weight gain (AWG) immediately after a postnatal slow weight gain (PSWG) on the risk of later overweight is unknown. The objective of this study was to assess the relationship between AWG after PSWG and overweight risk at 3 years of age.

Methods: This nested case-control study included 255 subjects born at term, appropriate for gestational age, and with normal birth weight but PSWG (< 0. Read More

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https://www.karger.com/Article/FullText/497154
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http://dx.doi.org/10.1159/000497154DOI Listing
February 2019
1 Read

Optimizing Vitamin and Trace Element Profiles in Blood after Gastrointestinal Tract Surgery by a New Parenteral Nutrition Formula.

Ann Nutr Metab 2019 22;74(3):189-199. Epub 2019 Feb 22.

Research and Development Center, Otsuka Pharmaceutical Factory Inc., Tokyo, Japan.

Introduction: Though micronutrient formulations for parenteral nutrition (PN) have been revised, the impacts of these changes on nutritional parameters, blood micronutrient levels, and safety have yet to be clarified. We examined the efficacy and safety of a new PN formulation with a micronutrient composition based on the Food and Drug Administration 2000 recommendation in surgical patients.

Methods: This phase III clinical trial (JapicCTI-No. Read More

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http://dx.doi.org/10.1159/000497227DOI Listing
February 2019

A Tribute to Richard Ehrenkranz.

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Ann Nutr Metab 2019 19;74(2):175-176. Epub 2019 Feb 19.

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http://dx.doi.org/10.1159/000497378DOI Listing
February 2019

Editorial.

Authors:
Frank M Ruemmele

Ann Nutr Metab 2018 19;73 Suppl 4:5-6. Epub 2019 Feb 19.

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http://dx.doi.org/10.1159/000493998DOI Listing
February 2019

Focus/Summary.

Authors:
Frank M Ruemmele

Ann Nutr Metab 2018 19;73 Suppl 4:38. Epub 2019 Feb 19.

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http://dx.doi.org/10.1159/000493996DOI Listing
February 2019

Focus/Summary.

Ann Nutr Metab 2018 19;73 Suppl 4:29. Epub 2019 Feb 19.

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http://dx.doi.org/10.1159/000493995DOI Listing
February 2019
1 Read

Focus/Summary.

Ann Nutr Metab 2018 19;73 Suppl 4. Epub 2019 Feb 19.

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http://dx.doi.org/10.1159/000493992DOI Listing
February 2019

Non-Celiac Gluten Sensitivity: A Challenging Diagnosis in Children with Abdominal Pain.

Authors:
Frank M Ruemmele

Ann Nutr Metab 2018 19;73 Suppl 4:39-46. Epub 2019 Feb 19.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France,

Several disorders related to the ingestion of gluten are well recognized despite overlapping clinical presentations: celiac disease, an autoimmune enteropathy triggered by gluten ingestions in susceptible individuals, allergy to wheat, and more recently non-celiac gluten sensitivity (NCGS). While celiac disease and wheat allergy are well-known disorders with a clear-cut diagnosis based on clinical tests and biological parameters, NCGS is a more difficult diagnosis, especially in children with functional gastrointestinal (GI) complaints. NCGS is considered a syndrome of intestinal but also extraintestinal symptoms occurring within hours, but sometimes even after several days of gluten ingestion. Read More

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http://dx.doi.org/10.1159/000493929DOI Listing
February 2019

Lactose Intolerance: Common Misunderstandings.

Ann Nutr Metab 2018 19;73 Suppl 4:30-37. Epub 2019 Feb 19.

Department of Translational Medical Science - Pediatric Section, University of Naples "Federico II", Naples, Italy,

Lactose intolerance primarily refers to a syndrome having different symptoms upon the consumption of foods containing lactose. It is one of the most common form of food intolerance and occurs when lactase activity is reduced in the brush border of the small bowel mucosa. Individuals may be lactose intolerant to varying degrees, depending on the severity of these symptoms. Read More

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http://dx.doi.org/10.1159/000493669DOI Listing
February 2019
9 Reads

Eosinophilic Gastrointestinal Diseases in Childhood.

Ann Nutr Metab 2018 19;73 Suppl 4:18-28. Epub 2019 Feb 19.

Division on Gastroenterology, Hepatology and Nutrition, First Department of Pediatrics, University of Athens, Children's Hospital "Agia Sofia", Athens, Greece,

Eosinophilic gastrointestinal diseases (EGIDs) comprise a group of chronic, inflammatory diseases of the gastrointestinal (GI) tract, that are characterized, clinically, by symptoms related to the dysfunction of the involved segment(s) of the GI tract, and histologically, by dense eosinophilic inflammation, in the absence of an identifiable secondary cause. The group of EGIDs comprises eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC). EoE is the most common and the best described EGID compared to EG, EGE, and EC. Read More

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http://dx.doi.org/10.1159/000493668DOI Listing
February 2019
2 Reads

Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes.

Ann Nutr Metab 2019 14;74(2):165-174. Epub 2019 Feb 14.

Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA,

Background: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes.

Objective: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes. Read More

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http://dx.doi.org/10.1159/000497226DOI Listing
February 2019
12 Reads

Low Levels of Serum β-Carotene and β-Carotene/Retinol Ratio Are Associated with Histological Severity in Nonalcoholic Fatty Liver Disease Patients.

Ann Nutr Metab 2019 13;74(2):156-164. Epub 2019 Feb 13.

Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China,

β-Carotene has been reported to alleviate hepatic steatosis (SS), inflammation, and fibrosis in vivo and vitro studies. However, the clinical relevance of serum β-carotene and β-carotene-to-retinol (SC/SR) ratio with histological severity in nonalcoholic fatty liver disease (NAFLD) patients is unknown. This case-control study enrolled 24 control subjects and 62 NAFLD patients. Read More

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http://dx.doi.org/10.1159/000496458DOI Listing
February 2019
1 Read

Effects of a Hypocaloric, Nutritionally Complete, Higher Protein Meal Plan on Regional Body Fat and Cardiometabolic Biomarkers in Older Adults with Obesity.

Ann Nutr Metab 2019 12;74(2):149-155. Epub 2019 Feb 12.

Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.

Background: Whether improvements in cardiometabolic health following weight loss (WL) are associated with changes in regional body fat distribution (gluteal vs. -android) is not well documented.

Methods: Older (age: 70 ± 4 years; mean ± SD) adults with obesity were randomized to a 6-month WL program (WL; n = 47), accomplished using a hypocaloric, nutritionally complete, higher protein -(targeting ≥1. Read More

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http://dx.doi.org/10.1159/000497066DOI Listing
February 2019
2 Reads

Decreased Na+/K+-ATPase Activity and Altered Susceptibility to Peroxidation and Lipid Composition in the Erythrocytes of Metabolic Syndrome Patients with Coronary Artery Disease.

Ann Nutr Metab 2019 7;74(2):140-148. Epub 2019 Feb 7.

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The increased generation of reactive oxygen species that occurs in the case of a metabolic syndrome (MetS) may be responsible for the increased oxidative injury to erythrocyte membranes in coronary artery disease (CAD). Therefore, we studied the effects of MetS on both indexes of oxidative damage and biochemical properties of erythrocyte membranes in CAD patients.

Methods: We analyzed the markers of oxidative stress, Na+/K+-ATPase activity, total cholesterol content of erythrocyte membranes (CEM), and fatty acid compositions of the erythrocyte membrane in 82 patients with stable CAD and 39 non-CAD subjects. Read More

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http://dx.doi.org/10.1159/000497065DOI Listing
February 2019
2 Reads

Abstracts of the 10th Workshop on Probiotics and Prebiotics.

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Ann Nutr Metab 2019 5;74 Suppl 1:1-31. Epub 2019 Feb 5.

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https://www.karger.com/Article/FullText/496759
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http://dx.doi.org/10.1159/000496759DOI Listing
February 2019
7 Reads

Effect of Delivery Mode and Nutrition on Gut Microbiota in Neonates.

Ann Nutr Metab 2019 4;74(2):132-139. Epub 2019 Feb 4.

Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan,

Background/aims: The mode of delivery (vaginal or cesarean section) and feeding type (breastfeeding or formula feeding) of neonates are considered the most influential factors in the development of gut microbiota.

Objectives: This study investigated the effect of prebiotic-rich breast milk on overcoming gut microbiota dysbiosis.

Method: Stool samples from 36 healthy Japanese neonates were obtained at 4 days and 1 month of age, and divided into 4 groups based on mode of delivery and feeding type. Read More

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http://dx.doi.org/10.1159/000496427DOI Listing
February 2019
2 Reads

Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations.

Ann Nutr Metab 2019 23;74(2):93-106. Epub 2019 Jan 23.

Medical University of Warsaw, Department of Paediatrics, Warsaw, Poland.

Background: A considerable body of evidence accumulated especially during the last decade, demonstrating that early nutrition and lifestyle have long-term effects on later health and disease ("developmental or metabolic programming").

Methods: Researchers involved in the European Union funded international EarlyNutrition research project consolidated the scientific evidence base and existing recommendations to formulate consensus recommendations on nutrition and lifestyle before and during pregnancy, during infancy and early childhood that take long-term health impact into account. Systematic reviews were performed on published dietary guidelines, standards and recommendations, with special attention to long-term health consequences. Read More

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http://dx.doi.org/10.1159/000496471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397768PMC
January 2019
3 Reads

Beneficial Effects of Probiotic Consumption on the Immune System.

Ann Nutr Metab 2019 23;74(2):115-124. Epub 2019 Jan 23.

Centro de Referencia para Lactobacilos (CERELA-CONICET), San Miguel de Tucumán, Argentina,

Background: The gastrointestinal tract is one of the most microbiologically active ecosystems that plays a crucial role in the working of the mucosal immune system (MIS). In this ecosystem, the consumed probiotics stimulate the immune system and induce a network of signals mediated by the whole bacteria or their cell wall structure. This review is aimed at describing the immunological mechanisms of probiotics and their beneficial effects on the host. Read More

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http://dx.doi.org/10.1159/000496426DOI Listing
January 2019
3 Reads

Low Body Mass Index and Myeloablative Conditioning Regimen Prolong the Duration of Parenteral Nutrition During Hematopoietic Stem Cell Transplantation.

Ann Nutr Metab 2019 23;74(2):107-114. Epub 2019 Jan 23.

Department of Pharmacy, Shiga University of Medical Science Hospital, Otsu, Japan.

Background/aims: Patients undergoing hematopoietic stem cell transplantation (HSCT) often receive total parenteral nutrition (TPN) due to poor oral intake. In clinical practice, it is difficult to predict adequate nutritional management, especially the duration of parenteral nutrition (PN), because of inter-individual variability in the conditions and types of treatment regimens. This study investigated the relationship between patient factors and the duration of TPN and the duration of PN. Read More

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http://dx.doi.org/10.1159/000496457DOI Listing
January 2019
3 Reads

Circulating Spexin Decreased and Negatively Correlated with Systemic Insulin Sensitivity and Pancreatic β Cell Function in Obese Children.

Ann Nutr Metab 2019 23;74(2):125-131. Epub 2019 Jan 23.

Department of Cardiology, Children's Hospital of Soochow University, Suzhou, China,

Objectives: Spexin (SPX) is a novel peptide that has recently emerged as an important regulatory adipokine of obesity and related metabolic disease. Little is known about its role in children. The aim of the current study was to determine the potential role of SPX in obese children and explore its relationships with obesity-related markers, insulin sensitivity and pancreatic β cell function. Read More

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https://www.karger.com/Article/FullText/496459
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http://dx.doi.org/10.1159/000496459DOI Listing
January 2019
5 Reads

International Society for the Study of Fatty Acids and Lipids 2018 Symposium: Arachidonic and Docosahexaenoic Acids in Infant Development.

Ann Nutr Metab 2019 7;74(1):83-91. Epub 2019 Jan 7.

DSM Nutritional Products, Inc, Columbia, Maryland, USA.

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https://www.karger.com/Article/FullText/495906
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http://dx.doi.org/10.1159/000495906DOI Listing
January 2019
3 Reads

Childhood Obesity: The Need to Translate Research into Daily Practice: Announcing the Annals of Nutrition and Metabolism as the Official Journal of the European Childhood Obesity Group.

Ann Nutr Metab 2019 7;74(1):80-82. Epub 2019 Jan 7.

Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont Auvergne University, Clermont-Ferrand, France.

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https://www.karger.com/Article/FullText/495905
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http://dx.doi.org/10.1159/000495905DOI Listing
January 2019
15 Reads

Contents vol. 73, 2018.

Authors:

Ann Nutr Metab 2018 6;73(4):I-VI. Epub 2018 Dec 6.

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https://www.karger.com/Article/FullText/495271
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http://dx.doi.org/10.1159/000495271DOI Listing
December 2018
2 Reads

A Mediterranean Diet with an Enhanced Consumption of Extra Virgin Olive Oil and Pistachios Improves Pregnancy Outcomes in Women Without Gestational Diabetes Mellitus: A Sub-Analysis of the St. Carlos Gestational Diabetes Mellitus Prevention Study.

Ann Nutr Metab 2019 14;74(1):69-79. Epub 2018 Dec 14.

Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain,

Aims: The aim of the study was to evaluate the effect of a Mediterranean diet (MedDiet), enhanced with extra virgin olive oil (EVOO) and nuts, on a composite of adverse maternofoetal outcomes of women with normoglycemia during pregnancy.

Methods: This was a sub-analysis of the St Carlos gestational diabetes mellitus Prevention Study. Only normoglycemic women were analysed (697). Read More

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https://www.karger.com/Article/FullText/495793
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http://dx.doi.org/10.1159/000495793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425818PMC
December 2018
24 Reads

Daily Supplementation with 4000 IU Vitamin D3 for Three Years Does Not Modify Cardiovascular Risk Markers in Patients with Advanced Heart Failure: The Effect of Vitamin D on Mortality in Heart Failure Trial.

Ann Nutr Metab 2019 14;74(1):62-68. Epub 2018 Dec 14.

Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr University Bochum, Bad Oeynhausen, Germany.

Background/aims: We aimed to investigate the effect of a moderately high vitamin D dose on lipid parameters and biochemical markers of vascular calcification (VC) in patients with established cardiovascular disease.

Methods: We included in this pre-specified secondary analysis of a randomized controlled trial 161 patients with advanced heart failure and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L (vitamin D group: n = 80; placebo group: n = 81), who received a daily vitamin D3 supplement of 4,000 IU for 3 years. We assessed between-group differences of the lipid parameters total-cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and triglycerides, and the VC markers fetuin-A and non-phosphorylated undercarboxylated matrix gla protein (MGP) at study termination, with adjustment for baseline values. Read More

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http://dx.doi.org/10.1159/000495662DOI Listing
December 2018
5 Reads
2.618 Impact Factor

Effects of Enteral Immunonutrition in Patients Undergoing Pancreaticoduodenectomy: A Meta-Analysis of Randomized Controlled Trials.

Ann Nutr Metab 2019 12;74(1):53-61. Epub 2018 Dec 12.

Department of General Surgery, Hepatobiliary and Pancreatic Laboratory of Anhui Province, Affiliated Provincial Hospital of Anhui Medical University, Hefei, China,

Background: The effect of enteral immunonutrition (EIN) in patients undergoing pancreaticoduodenectomy (PD) is still doubtful. This meta-analysis aimed to assess the impact of EIN on postoperative clinical outcomes for patients undergoing PD.

Methods: A literature search was carried out to identify all of the randomized controlled trials (RCTs) concerning the use of EIN for PD. Read More

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http://dx.doi.org/10.1159/000495468DOI Listing
December 2018
2 Reads

Influence of Nutritional Management and Rehabilitation on Physical Outcome in Japanese Intensive Care Unit Patients: A Multicenter Observational Study.

Ann Nutr Metab 2019 12;74(1):35-43. Epub 2018 Dec 12.

Emergency and Critical Care Medicine, Tokushima University Graduate School, Tokushima, Japan.

Background: There is lack of evidence regarding nutritional management among intensive care unit (ICU) patients in a population with relatively low body mass index. Therefore, we conducted an observational study to assess the nutritional management in Japanese ICUs. Also, we investigated the impact of nutritional management and rehabilitation on physical outcome. Read More

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https://www.karger.com/Article/FullText/495213
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http://dx.doi.org/10.1159/000495213DOI Listing
December 2018
7 Reads

Association of Circulating Adipsin, Visfatin, and Adiponectin with Nonalcoholic Fatty Liver Disease in Adults: A Case-Control Study.

Ann Nutr Metab 2019 12;74(1):44-52. Epub 2018 Dec 12.

Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China,

Background/aims: Some adipokines, such as adiponectin and leptin, have been reported to be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), while the association of adipsin and visfatin with NAFLD still remains unclear. This study aimed to examine the association of circulating adipsin, visfatin, and adiponectin with NAFLD in Chinese adults.

Methods: We recruited a total of 211 eligible subjects, including 100 NAFLD cases and 111 age and sex frequency-matched controls. Read More

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https://www.karger.com/Article/FullText/495215
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http://dx.doi.org/10.1159/000495215DOI Listing
December 2018
16 Reads

Risk Assessment Paradigm for Glutamate.

Ann Nutr Metab 2018 3;73 Suppl 5:53-64. Epub 2018 Dec 3.

Division of Toxicology, Wageningen University, Wageningen, The Netherlands,

Background: Re-evaluation of the use of glutamic acid and glutamate salts (referred to as glutamate hereafter) by the European Food Safety Authority (EFSA) proposed a group acceptable daily intake (ADI) of 30 mg/kg body weight (bw)/day.

Summary: This ADI is below the normal dietary intake, while even intake of free glutamate by breast-fed babies can be above this ADI. In addition, the pre-natal developmental toxicity study selected by EFSA, has never been used by regulatory authorities worldwide for the safety assessment of glutamate despite it being available for nearly 40 years. Read More

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http://dx.doi.org/10.1159/000494783DOI Listing
December 2018
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Monosodium Glutamate in the Diet Does Not Raise Brain Glutamate Concentrations or Disrupt Brain Functions.

Authors:
John D Fernstrom

Ann Nutr Metab 2018 3;73 Suppl 5:43-52. Epub 2018 Dec 3.

Department of Psychiatry, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA,

The non-essential amino acid glutamate participates in numerous metabolic pathways in the body. It also performs important physiologic functions, which include a sensory role as one of the basic tastes (as monosodium glutamate [MSG]), and a role in neuronal function as the dominant excitatory neurotransmitter in the central nervous system. Its pleasant taste (as MSG) has led to its inclusion as a flavoring agent in foods for centuries. Read More

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http://dx.doi.org/10.1159/000494782DOI Listing
December 2018
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A Test of Dietary Monosodium Glutamate Developmental Neurotoxicity in Rats: A Reappraisal.

Ann Nutr Metab 2018 3;73 Suppl 5:36-42. Epub 2018 Dec 3.

Department of Pediatrics, University of Cincinnati College of Medicine and Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA,

In 1979, we tested dietary monosodium glutamate (MSG) for developmental neurotoxicity in rats. The study was recently cited for establishing a No Observable Adverse Effect Level (NOAEL) for MSG as a food additive resulting in a change in the acceptable daily intake (ADI). Therefore, I re-evaluated the study [Vorhees et al. Read More

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https://www.karger.com/Article/FullText/494781
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http://dx.doi.org/10.1159/000494781DOI Listing
December 2018
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Glutamate Supply and Metabolism in Infants.

Ann Nutr Metab 2018 3;73 Suppl 5:29-35. Epub 2018 Dec 3.

Ludwig-Maximilians-University Munich, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany,

Glutamate (Glu) is the most abundant amino acid (AA) in human milk. Available information on Glu supply and metabolism was reviewed, based on an electronic literature search. In 22 cross-sectional global studies with 4,747 women, free Glu increases with lactation duration and contributes to about 38% of total and 63% of dispensable milk AA. Read More

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https://www.karger.com/Article/FullText/494780
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http://dx.doi.org/10.1159/000494780DOI Listing
December 2018
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Review of Glutamate Intake from Both Food Additive and Non-Additive Sources in the European Union.

Authors:
David R Tennant

Ann Nutr Metab 2018 3;73 Suppl 5:21-28. Epub 2018 Dec 3.

Independent Scientific Adviser, Food Chemical Risk Analysis, East Sussex, East Dean, United Kingdom,

Background: Intakes of glutamate can be derived from its natural occurrence as a constituent of proteins, from the presence of free glutamate in certain fermented foods, and from the addition of glutamic acid and glutamates to foods as flavor-enhancing additives.

Summary: Intakes of glutamate following hydrolysis of dietary proteins can be as high as 440 mg/kg bw/day for toddlers and small children. High-level intakes of glutamate from its natural occurrence  in foods or from the use of food additives, given very conservative assumptions about conditions of use, are -similar at around 80 mg/kg bw/day for toddlers and small children. Read More

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http://dx.doi.org/10.1159/000494778DOI Listing
December 2018
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The Roles of Dietary Glutamate in the Intestine.

Authors:
Daniel Tomé

Ann Nutr Metab 2018 3;73 Suppl 5:15-20. Epub 2018 Dec 3.

UMR PNCA, INRA, AgroParisTech, Université Paris-Saclay, Paris, France,

Glutamate (Glu), either as one of the amino acids of protein or in free form, constitutes up to 8-10% of amino acid content in the human diet, with an intake of about 10-20 g/day in adults. In the intestine, postprandial luminal Glu concentrations can be of the order of mM and result in a high intra-mucosal Glu concentration. Glu absorbed from the intestinal lumen is for a large part metabolized by enterocytes in various pathways, including the production of energy to support intestinal motility and functions. Read More

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http://dx.doi.org/10.1159/000494777DOI Listing
December 2018
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Metabolism of Dietary Glutamate in Adults.

Authors:
Luc Cynober

Ann Nutr Metab 2018 3;73 Suppl 5:5-14. Epub 2018 Dec 3.

Clinical Chemistry Department, Cochin Hospital, AP-HP, Paris, France,

Background: Glutamate is a non-essential amino acid at the crossroads of nitrogen and energy metabolism. Glutamate metabolism is characterized by reactions that may be anabolic or catabolic in nature depending on the tissue (i.e. Read More

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http://dx.doi.org/10.1159/000494776DOI Listing
December 2018
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Introduction and Summary of the 2018 Dietary Glutamate Workshop.

Ann Nutr Metab 2018 3;73 Suppl 5:1-4. Epub 2018 Dec 3.

Department of Pediatrics, University of Cincinnati College of Medicine and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, Ohio, USA.

The 2018 Dietary Glutamate Workshop was organized and sponsored by the International Glutamate Technical Committee to provide a platform for a broad expert discussion on all relevant aspects of glutamate metabolism and safety in human nutrition. The participants reached a consensus with previous safety evaluations conducted by the global expert bodies, but contradicted the 2017 re-evaluation of dietary glutamates by the European Food Safety Authority, which proposed a group acceptable daily intake (ADI) of 30 mg/kg body weight per day. The participants of the Workshop concluded that the present knowledge on metabolism, kinetics, developmental and general toxicity of dietary glutamates did not warrant a change in the previous ADI of "not specified. Read More

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http://dx.doi.org/10.1159/000494775DOI Listing
December 2018
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Computed Tomography-Assessed Sarcopenia Indexes Predict Major Complications following Surgery for Hepatopancreatobiliary Malignancy: A Meta-Analysis.

Ann Nutr Metab 2019 4;74(1):24-34. Epub 2018 Dec 4.

Wuhan University, Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China,

Background: Computed tomography (CT)-assessed sarcopenia indexes have been reported to predict postoperative morbidity and mortality; however conclusions drawn from different indexes and studies remain controversial.

Aim: The purpose of this meta-analysis was to evaluate various CT-assessed sarcopenia indexes as predictors of risk for major complications in patients undergoing hepatopancreatobiliary surgery for malignancy.

Methods: Medline/PubMed, Web of Science, and Embase databases were systematically searched to identify relevant studies published before June 2018. Read More

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http://dx.doi.org/10.1159/000494887DOI Listing
December 2018
2 Reads