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    1195 results match your criteria Annals of Noninvasive Electrocardiology [Journal]

    1 OF 24

    Loperamide cardiotoxicity: "A Brief Review".
    Ann Noninvasive Electrocardiol 2017 Nov 10. Epub 2017 Nov 10.
    Department of Electrophysiology, Staten Island University Hospital, Staten Island, NY, USA.
    Loperamide is a popular antidiarrheal medication that has been used for many years. It is currently gaining more attention among healthcare professionals due to its increasing potential for side effects. At present, it is considered safe enough to be sold over the counter. Read More

    Efficacy and safety of intravenous vernakalant for the rapid conversion of recent-onset atrial fibrillation: A meta-analysis.
    Ann Noninvasive Electrocardiol 2017 Nov 4. Epub 2017 Nov 4.
    Department of Cardiology, Staten Island University Hospital, NY, USA.
    Background: Atrial fibrillation is a common cardiac arrhythmia with increasing prevalence in the aging population. It is a major cause of emergency department visits worldwide. Vernakalant, a relatively new antiarrhythmic drug with selectively preferential effects on the atrial tissue is currently used in many European countries for the termination of recent-onset atrial fibrillation. Read More

    Clinical applications of QT/RR hysteresis assessment: A systematic review.
    Ann Noninvasive Electrocardiol 2017 Oct 30. Epub 2017 Oct 30.
    Department of Kinesiology, University of Montreal, Montreal, QC, Canada.
    Background: QT/RR hysteresis (QT-hys) is an index of the time accommodation of ventricular repolarization to heart rate changes. This report comprehensively reviews studies addressing QT-hys as a biomarker of medical conditions.

    Methods: This is a secondary analysis of data from a recent systematic review pertaining to methods of assessment of QT-hys. Read More

    Catecholaminergic polymorphic ventricular tachycardia, an update.
    Ann Noninvasive Electrocardiol 2017 Oct 19. Epub 2017 Oct 19.
    Design of Studies and Scientific Writing Laboratory in the ABC Medicine Faculty, Santo André, São Paulo, Brazil.
    Catecholaminergic polymorphic ventricular tachycardia is a rare devastating lethal inherited disorder or sporadic cardiac ion channelopathy characterized by unexplained syncopal episodes, and/or sudden cardiac death (SCD), aborted SCD (ASCD), or sudden cardiac arrest (SCA) observed in children, adolescents, and young adults without structural heart disease, consequence of adrenergically mediated arrhythmias: exercise-induced, by acute emotional stress, atrial pacing, or β-stimulant infusion, even when the electrocardiogram is normal. The entity is difficult to diagnose in the emergency department, given the range of presentations; thus, a familiarity with and high index of suspicion for this pathology are crucial. Furthermore, recognition of the characteristic findings and knowledge of the management of symptomatic patients are necessary, given the risk of arrhythmia recurrence and SCA. Read More

    The effect of head-up tilt upon markers of heart rate variability in patients with atrial fibrillation.
    Ann Noninvasive Electrocardiol 2017 Oct 15. Epub 2017 Oct 15.
    National Heart and Lung Institute, Imperial College, London, United Kingdom.
    Background: Heart rate variability (HRV) analysis is uncommonly undertaken in patients with atrial fibrillation (AF) due to an assumption that ventricular response is random. We sought to determine the effects of head-up tilt (HUT), a stimulus known to elicit an autonomic response, on HRV in patients with AF; we contrasted the findings with those of patients in sinus rhythm (SR).

    Methods: Consecutive, clinically indicated tilt tests were examined for 207 patients: 176 in SR, 31 in AF. Read More

    Heart failure study of multipoint pacing effects on ventriculoarterial coupling: Rationale and design of the HUMVEE trial.
    Ann Noninvasive Electrocardiol 2017 Oct 15. Epub 2017 Oct 15.
    First University Department of Cardiology, Hippokration Hospital, Athens, Greece.
    Cardiac resynchronization therapy (CRT) is an established therapy for symptomatic heart failure (HF). Unfortunately, many recipients remain nonresponders. Studies have revealed the potential role of multipoint pacing (MPP) in improving response and outcomes. Read More

    Recurrent extensive anterior myocardial infarction with left and right bundle branch block.
    Ann Noninvasive Electrocardiol 2017 Oct 15. Epub 2017 Oct 15.
    The Cardiovascular Institute of the First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning Province, China.
    The diagnosis of myocardial infarction with left bundle branch block is difficult. We report a case of 56-year-old man with old extensive anterior myocardial infarction and left bundle branch block (masked each other). The recurrent myocardial infarction indicated right bundle branch block and first-degree atrioventricular block, making a clear diagnosis of complicated and interesting ECG. Read More

    Brugada phenocopy caused by a compressive mediastinal tumor.
    Ann Noninvasive Electrocardiol 2017 Oct 15. Epub 2017 Oct 15.
    Design of Studies and Scientific Writing Laboratory of the ABC School of Medicine, Santo André, Brazil.
    Recently, it has been shown that even experts in electrocardiography cannot differentiate the electrocardiographic pattern of genuine Brugada syndrome (BrS) from Brugada phenocopy (BrP). For this reason, this differentiation depends on the presence of established criteria both for BrS and BrP. In this manuscript, we present a patient with type 1 Brugada electrocardiographic pattern caused by expansive anterior mediastinal non-Hodgkin's lymphoma (NHL) with mechanical compression on the right ventricular outflow tract. Read More

    Baseline fragmented QRS increases the risk of major arrhythmic events in Brugada syndrome: Systematic review and meta-analysis.
    Ann Noninvasive Electrocardiol 2017 Oct 14. Epub 2017 Oct 14.
    Department of Internal Medicine, University of Michigan Medical School, Michigan Medicine, Ann Arbor, MI, USA.
    Background: Fragmented QRS reflects disturbances in the myocardium predisposing the heart to ventricular tachyarrhythmias. Recent studies suggest that fragmented QRS (fQRS) is associated with major arrhythmic events in Brugada syndrome. However, a systematic review and meta-analysis of the literature has not been done. Read More

    The prognostic significance of early and late right precordial lead (V4 R) ST-segment elevation in patients with acute anterior myocardial infarction.
    Ann Noninvasive Electrocardiol 2017 Oct 14. Epub 2017 Oct 14.
    Department of Cardiology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
    Background: The predictive significance of ST-segment elevation (STE) in lead V4 R in patients with anterior ST-segment elevation myocardial infarction (STEMI) has not been well-understood. In this study, we evaluated the prognostic value of early and late STE in lead V4 R in patients with anterior STEMI.

    Methods: A total 451 patients with anterior STEMI who treated with primary percutaneous coronary intervention (PPCI) were prospectively enrolled in this study. Read More

    Propensity score matching analysis of the impact of Syntax score and Syntax score II on new onset atrial fibrillation development in patients with ST segment elevation myocardial infarction.
    Ann Noninvasive Electrocardiol 2017 Oct 4. Epub 2017 Oct 4.
    Ataturk Universitesi, Medical School, Department of Cardiology, Erzurum, Turkey.
    Background: New-onset atrial fibrillation (NOAF) is a common complication in the setting of ST segment elevation myocardial infarction (STEMI), and worsened short/long-term prognosis. Several clinical parameters have already been associated with NOAF development. However, relationship between NOAF and coronary artery disease (CAD) severity in STEMI patients is unclear. Read More

    Parathyroid hormone is related to QT interval independent of serum calcium in patients with coronary artery disease.
    Ann Noninvasive Electrocardiol 2017 Sep 26. Epub 2017 Sep 26.
    Columbia University Medical Center, New York, NY, USA.
    Background: Elevated serum parathyroid hormone (PTH) is associated with increased risk of cardiovascular death, including sudden cardiac death, in patients with and without parathyroid disease. In small studies, PTH levels have been associated with changes in cardiac conduction and repolarization. Changes in the corrected QT interval (QTc) in particular are thought to be mediated by the effect of PTH on serum calcium. Read More

    Marked exercise-induced T-wave heterogeneity in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis.
    Ann Noninvasive Electrocardiol 2017 Sep 26. Epub 2017 Sep 26.
    Beth Israel Deaconess Medical Center, Boston, MA, USA.
    Background: T-wave heterogeneity (TWH) independently predicted cardiovascular mortality in Health Survey 2000 based on 12-lead ECGs recorded at rest. We investigated whether TWH is elevated during exercise tolerance testing (ETT) in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis compared to control subjects without diabetes.

    Methods: Cases were all patients (n = 20) with analyzable ECG recordings during both rest and ETT who were enrolled in the Effects of Ranolazine on Coronary Flow Reserve (CFR) in Symptomatic Patients with Diabetes and Suspected or Known Coronary Artery Disease (RAND-CFR) study (NCT01754259); median CFR was 1. Read More

    Main artifacts in electrocardiography.
    Ann Noninvasive Electrocardiol 2017 Sep 20. Epub 2017 Sep 20.
    Design of Studies and Scientific Writing Laboratory at the ABC School of Medicine, Santo André, São Paulo, Brazil.
    Electrocardiographic artifacts are defined as electrocardiographic alterations, not related to cardiac electrical activity. As a result of artifacts, the components of the electrocardiogram (ECG) such as the baseline and waves can be distorted. Motion artifacts are due to shaking with rhythmic movement. Read More

    Postimplantation ventricular ectopic burden and clinical outcomes in cardiac resynchronization therapy-defibrillator patients: a MADIT-CRT substudy.
    Ann Noninvasive Electrocardiol 2017 Sep 20. Epub 2017 Sep 20.
    Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, NY, USA.
    Background: Frequent ventricular ectopy on preimplantation Holter has been associated with attenuated benefit from cardiac resynchronization therapy (CRT). However, it is unclear whether ectopic burden measured post-CRT implantation can be utilized to evaluate long-term prognosis. We aimed to describe the association between post-CRT implantation ectopic burden and subsequent risk of clinical outcomes. Read More

    Myocardial bridging is associated with exercise-induced ventricular arrhythmia and increases in QT dispersion.
    Ann Noninvasive Electrocardiol 2017 Sep 18. Epub 2017 Sep 18.
    The Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
    Background: A myocardial bridge (MB) has been associated with ventricular arrhythmia and sudden death during exercise. QT dispersion (QTd) is a measure of abnormal repolarization and may predict ventricular arrhythmia. We investigated the frequency of ventricular arrhythmias during exercise and the QTd at rest and after exercise, in patients with an MB compared to a normal cohort. Read More

    Sudden cardiac death in isolated right ventricular hypertrabeculation/noncompaction cardiomyopathy.
    Ann Noninvasive Electrocardiol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Cardiovascular Medicine and Electrophysiology, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.
    Hypertrabeculation/noncompaction of the myocardium is a rare disorder that involves most commonly the left ventricle of the heart and it has been recognized as a distinct cardiomyopathy by the World Health Organization. However, it is extremely rare for this condition to involve exclusively the right ventricle. We report the cases of three patients who presented with ventricular tachyarrhythmia and sudden cardiac death. Read More

    Specificity of wide QRS complex tachycardia criteria and algorithms in patients with ventricular preexcitation.
    Ann Noninvasive Electrocardiol 2017 Sep 12. Epub 2017 Sep 12.
    First Department of Cardiology, Interventional Electrocardiology and Hypertension, Medical College, Jagiellonian University, Cracow, Poland.
    Background: Despite substantial progress in the field of differentiation between ventricular tachycardia (VT) and supraventricular tachycardia (SVT) with wide QRS complexes, differentiation between VT and preexcited SVT remains largely unresolved due to significant overlap in QRS morphology. Our aim was to assess the specificities of various single ECG criteria and sets of criteria (Brugada algorithm, aVR algorithm, Steurer algorithm, and the VT score) for diagnosis of VT in a sizable cohort of patients with preexcitation.

    Methods: We performed a retrospective study of consecutive accessory pathway ablation procedures to identify preexcited tachycardias. Read More

    Total cosine R-to-T for predicting ventricular arrhythmic and mortality outcomes: A systematic review and meta-analysis.
    Ann Noninvasive Electrocardiol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
    Background: The total cosine R-to-T (TCRT), a vectorcardiographic marker reflecting the spatial difference between the depolarization and repolarization wavefronts, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) in different clinical settings. However, its prognostic value has been controversial.

    Objective: This systematic review and meta-analysis evaluated the significance of TRCT in predicting arrhythmic and/or mortality endpoints. Read More

    Pregbalin induced recurrent syncopal attacks with prolong QT interval.
    Ann Noninvasive Electrocardiol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Cardiology, Faculty of Medicine, Karabuk University, Karabuk, Turkey.
    Long QT syndrome may lead to fatal dysrhythmia. Prolongation of QT interval due to pregabalin has been shown in rats and no data is available in humans. We report a 80-year-old female patient using pregabalin. Read More

    Premature ventricular contraction-induced concealed retrograde penetration: Electrocardiographic manifestations on anterograde ventricular preexcitation.
    Ann Noninvasive Electrocardiol 2017 Aug 24. Epub 2017 Aug 24.
    Division of Cardiology, Queen's University, Kingston, ON, Canada.
    In patients with manifest anterograde ventricular preexcitation, the electrocardiographic manifestation of the anomalous conduction through the simultaneous conduction over the atrioventricular (AV) node and the accessory pathway ("delta wave"); depends on several factors, the most representative being the conduction velocity over one or another connection. Occasionally, ventricular ectopic beats may present with retrograde penetration over one or both conduction pathways (AV node and/or accessory pathway), impacting on the morphology of the next immediate anterogradely conducted QRS. We present a case of a young patient with WPW syndrome and ectopic ventricular beats with different manifestations on the postectopic QRS due to concealed penetration of different conduction pathways. Read More

    Role of surface electrocardiogram precordial leads in localizing different anatomic sites of ectopic atrial tachycardia arising from lower right atrium in pediatric population.
    Ann Noninvasive Electrocardiol 2017 Aug 19. Epub 2017 Aug 19.
    Cardiology Department, Ain Shams University, Cairo, Egypt.
    Background: The study was designed to examine P wave morphology (PWM) in precordial leads (V1 -V6 ) during ectopic atrial tachycardia (EAT) originating from low right atrium (RA) to identify the anatomic sites of these foci in children.

    Methods: Twenty-three consecutive pediatric patients (56% females, mean age 8.5 ± 2. Read More

    Supraventricular tachycardia, pregnancy, and water: A new insight in lifesaving treatment of rhythm disorders.
    Ann Noninvasive Electrocardiol 2017 Aug 19. Epub 2017 Aug 19.
    Cardiology Section, "S. Paolo" Hospital ASL BA, Bari, Italy.
    Pregnancy may predispose to paroxysmal supraventricular tachycardia (SVT), in subjects with or without identifiable heart disease. Many physiological conditions such as autonomic nervous system changes, altered systemic hemodynamics, etc. can contribute to the onset of arrhythmias during pregnancy. Read More

    Impact of functional training on geometric indices and fractal correlation property of heart rate variability in postmenopausal women.
    Ann Noninvasive Electrocardiol 2017 Jul 25. Epub 2017 Jul 25.
    ABC Medical School (FMABC), Santo André, São Paulo, Brazil.
    Background: To evaluate the influence of functional training on the geometric indices of heart rate variability (HRV) and fractal correlation properties of the dynamics of heart rate in menopausal women.

    Methods: Of 39 women who were in the period of menopause for more than a year and who did not practice any regular physical activity were divided into: Functional training group (FTG = 50 ± 4.5 years; 67. Read More

    The sensitivity of 38 heart rate variability measures to the addition of artifact in human and artificial 24-hr cardiac recordings.
    Ann Noninvasive Electrocardiol 2017 Jul 2. Epub 2017 Jul 2.
    School of Medicine Flinders University, Adelaide, SA, Australia.
    Background: Artifact is common in cardiac RR interval data derived from 24-hr recordings and has a significant impact on heart rate variability (HRV) measures. However, the relative impact of progressively added artifact on a large group of commonly used HRV measures has not been assessed. This study compared the relative sensitivity of 38 commonly used HRV measures to artifact to determine which measures show the most change with increasing increments of artifact. Read More

    Congenital Long QT syndrome and torsade de pointes.
    Ann Noninvasive Electrocardiol 2017 Nov 2;22(6). Epub 2017 Jul 2.
    Downstate Medical Center, State University of New York, Brooklyn, NY, USA.
    Since its initial description by Jervell and Lange-Nielsen in 1957, the congenital long QT syndrome (LQTS) has been the most investigated cardiac ion channelopathy. A prolonged QT interval in the surface electrocardiogram is the sine qua non of the LQTS and is a surrogate measure of the ventricular action potential duration (APD). Congenital as well as acquired alterations in certain cardiac ion channels can affect their currents in such a way as to increase the APD and hence the QT interval. Read More

    The association of QT interval components with atrial fibrillation.
    Ann Noninvasive Electrocardiol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
    Background: Although abnormalities of the QT interval are associated with atrial fibrillation (AF), it is unclear whether ventricular depolarization (QRS duration) or repolarization (JT interval) is a more important marker of AF risk.

    Methods: This analysis included 4,181 (95% white; 59% women) participants from the Cardiovascular Health Study (CHS) who were free of baseline AF and major intraventricular delay. A linear scale was used to compute heart rate adjusted QT (QTa), QRS (QRSa ), and JT (JTa ) intervals. Read More

    A rare form of extremely wide QRS complex due to reversed homologous electrical ventricular separation of acute heart failure.
    Ann Noninvasive Electrocardiol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Electrical ventricular separation, as a special complete intraventricular block, denotes that ventricles be electrically separated into two or more parts caused by severe and wide damage of myocardium and conduction. Electrical ventricular separation can be divided into homologous and heterologous, homologous electrical ventricular separation is a rare phenomenon, literally the excitement of whole ventricle originate from supraventricle, on ECG, there are two different QRS waves which connect with an isoelectric line, one ST segment and T wave. We report a valve heart disease presented with complicated electrophysiological characteristics, which has reversed complex homologous electrical ventricular separation with second degree intraventricular block. Read More

    Ranolazine reduces repolarization heterogeneity in symptomatic patients with diabetes and non-flow-limiting coronary artery stenosis.
    Ann Noninvasive Electrocardiol 2017 Jun 27. Epub 2017 Jun 27.
    Beth Israel Deaconess Medical Center, Boston, MA, USA.
    Background: Experimental evidence suggests that ranolazine decreases susceptibility to ischemia-induced arrhythmias independent of effects on coronary artery blood flow.

    Objective: In symptomatic diabetic patients with non-flow-limiting coronary artery stenosis with diffuse atherosclerosis and/or microvascular dysfunction, we explored whether ranolazine reduces T-wave heterogeneity (TWH), an electrocardiographic (ECG) marker of arrhythmogenic repolarization abnormalities shown to predict sudden cardiac death.

    Methods: We studied all 16 patients with analyzable ECG recordings during rest and exercise tolerance testing before and after 4 weeks of ranolazine in the double-blind, crossover, placebo-controlled RAND-CFR trial (NCT01754259). Read More

    Bigeminal sandwiches galore.
    Ann Noninvasive Electrocardiol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Clinical Sciences Lund, Clinical Physiology, Skane University Hospital, Lund University, Lund, Sweden.
    A long run of PVCs "sandwiched" in between the sinus beats resulting in an almost doubling of the heart rate-interpolated PVCs in bigeminy-is described. This case illustrates three interesting aspects of interpolated PVCs. Although they are not uncommon, long runs of interpolated PVCs in bigeminy are rare findings. Read More

    Asystole caused by Hydroxycut Hardcore: A case report and literature review.
    Ann Noninvasive Electrocardiol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Cardiovascular & Electrophysiology Medicine, Staten Island University Hospital, Staten Island, NY, USA.
    Obesity is a rising epidemic worldwide driving people to search for remedy through nonconventional therapies. Hydroxycut products are popular supplements used as weight loss aids. Many reports revealed serious adverse effects related to their ingestion. Read More

    ECG-derived Cheyne-Stokes respiration and periodic breathing in healthy and hospitalized populations.
    Ann Noninvasive Electrocardiol 2017 Nov 15;22(6). Epub 2017 Jun 15.
    University of California, San Francisco, San Francisco, CA, USA.
    Background: Cheyne-Stokes respiration (CSR) has been investigated primarily in outpatients with heart failure. In this study we compare CSR and periodic breathing (PB) between healthy and cardiac groups.

    Methods: We compared CSR and PB, measured during 24 hr of continuous 12-lead electrocardiographic (ECG) Holter recording, in a group of 90 hospitalized patients presenting to the emergency department with symptoms suggestive of acute coronary syndrome (ACS) to a group of 100 healthy ambulatory participants. Read More

    Electrical storm in a patient with Duchenne muscular dystrophy cardiomyopathy triggered by abrupt β-blocker interruption.
    Ann Noninvasive Electrocardiol 2017 Nov 15;22(6). Epub 2017 Jun 15.
    Third Department of Cardiology, Hippokration Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    We present a case of a young man with Duchenne muscular dystrophy cardiomyopathy (DMDC) having an implantable cardioverter defibrillator for secondary prevention, who presented with electrical storm shortly after β-blocker interruption. The patient was stabilized and remained free of ventricular arrhythmias soon after reinitiating b-adrenoreceptor antagonists. The present case highlights the importance of sympathetic blockage in patients with DMDC due to existing pathophysiology of excess diastolic Ca(2+) leak from sarcoplasmic reticulum as a result of ryanodine receptor dysfunction. Read More

    New insights into the clinical signs of supraventricular tachycardia: The "sign of lace-tying".
    Ann Noninvasive Electrocardiol 2017 Jun 8. Epub 2017 Jun 8.
    Catholic University of Louvain, CHU UCL Namur, Cardiology Service, Yvoir, Belgium.
    Background: Supraventricular tachycardias (SVT) are a common arrhythmia therefore an accurate diagnosis is of clinical importance. Although an ECG performed during tachycardia greatly aids diagnosis, patient history and predisposing factors also improve diagnostic accuracy.

    Methods: This prospective study included 100 consecutive patients undergoing electrophysiological study for SVT with the aim to reassess their clinical characteristics and describe frequent predisposing factors, such as the "sign of lace-tying" that to our knowledge has not previously been reported. Read More

    Inhibition of left ventricular stimulation due to left ventricular lead failure and the left ventricular T-wave protection algorithm in patient with cardiac resynchronization therapy and pacemaker dependency.
    Ann Noninvasive Electrocardiol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Electrocardiology, The John Paul II Hospital, Kraków, Poland.
    The electrocardiogram (ECG) interpretation in patients with cardiac resynchronization therapy (CRT) is often a perplexing problem. The difficulty in the device evaluation increases in the presence of unfamiliar timing cycles and a lead dysfunction. Authors describe a special function of a Biotronik CRT devices called the left ventricle T-wave protection (LVTP), and demonstrate its behavior in a patient with left ventricular (LV) lead failure. Read More

    Effects of intranasal kinetic oscillation stimulation on heart rate variability.
    Ann Noninvasive Electrocardiol 2017 Jun 7. Epub 2017 Jun 7.
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA.
    Background: Kinetic oscillation stimulation in the nasal cavity (KOS) has been shown to have positive symptomatic effects in subjects with non-allergic rhinitis and in patients with migraine.

    Methods: To evaluate the effect of KOS on autonomic function, we assessed heart rate variability (HRV) in this small exploratory study in 12 healthy subjects. KOS treatment was performed using a minimally invasive system with a single-use catheter inserted into the nasal cavity. Read More

    Changes in arrhythmogenic properties and five-year prognosis after carbon-ion radiotherapy in patients with mediastinum cancer.
    Ann Noninvasive Electrocardiol 2017 Jun 7. Epub 2017 Jun 7.
    National Institute of Radiological Sciences, Inage, Japan.
    Introduction: Carbon-ion irradiation of rabbit hearts has improved left ventricular conduction abnormalities through upregulation of gap junctions. However, to date, there has been no investigation on the effect of carbon-ion irradiation on electrophysiological properties in human. We investigated this effect in patients with mediastinum extra-cardiac cancer treated with carbon-ion radiotherapy that included irradiating the heart. Read More

    Progression of early repolarization patterns at a four year follow-up in a female flight crew population: Implications for aviation medicine.
    Ann Noninvasive Electrocardiol 2017 Nov 30;22(6). Epub 2017 May 30.
    Department of Cardiology, Clermont Tonnerre Army Training Hospital, Brest, France.
    Background: To assess the prevalence, the appearance, and the distribution, as well as the fluctuation over time of early repolarization patterns after four years in a female population derived from the French aviation sector.

    Methods: This was a retrospective longitudinal study from 1998 to 2010 of a population of female employees who received a full clinical examination and an electrocardiogram (ECG) upon their recruitment and after a period of four years.

    Results: A total of 306 women were included (average of 25. Read More

    Coronary sinus lead delay index for optimization of coronary sinus lead placement.
    Ann Noninvasive Electrocardiol 2017 May 30. Epub 2017 May 30.
    Department of Cardiology, Adana Health Practices and Research Center, Health Sciences University, Adana, Turkey.
    Aim: Optimization of coronary sinus (CS) lead position to the latest activated left ventricular (LV) area is important to increase cardiac resynchronization therapy (CRT) response. We aimed to detect the relationship between coronary sinus lead delay index (CSDI) and echocardiographic, electrocardiographic response to CRT treatment.

    Methods: We prospectively included 137 consecutive patients with heart failure (HF) diagnosis, QRS ≥ 120 ms, left bundle branch block (LBBB), New York Heart Association score (NYHA) II-IV, LV ejection fraction (LVEF) <35% and scheduled for CRT (84 male, 53 female; mean age 65. Read More

    Repetitive ventricular tachycardia in a syncopal child: Cause or incidental finding ?
    Ann Noninvasive Electrocardiol 2017 May 30. Epub 2017 May 30.
    Division of Pediatric Cardiology, Queen Fabiola Children's University Hospital Free University of Brussels ULB, Brussels, Belgium.
    A 15-year-old girl suffered recurrent syncopal episodes during 7 years. Events were precipitated by exercise or emotional stress, leading to the diagnosis of reflex syncope. Exercise testing induced recurrent salvos of nonsustained right ventricular outflow tract tachycardia. Read More

    Rationale and design of a randomized trial to assess the safety and efficacy of MultiPoint Pacing (MPP) in cardiac resynchronization therapy: The MPP Trial.
    Ann Noninvasive Electrocardiol 2017 Nov 18;22(6). Epub 2017 May 18.
    Aurora Cardiovascular Services, Milwaukee, WI, USA.
    Background: Although the majority of Class III congestive heart failure (HF) patients treated with cardiac resynchronization therapy (CRT) show a clinical benefit, up to 40% of patients do not respond to CRT. This paper reports the design of the MultiPoint Pacing (MPP) trial, a prospective, randomized, double-blind, controlled study to evaluate the safety and efficacy of CRT using MPP compared to standard biventricular (Bi-V) pacing.

    Methods: A maximum of 506 patients with a standard CRT-D indication will be enrolled at up to 50 US centers. Read More

    Categorization and theoretical comparison of quantitative methods for assessing QT/RR hysteresis.
    Ann Noninvasive Electrocardiol 2017 Jul 16;22(4). Epub 2017 May 16.
    Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montréal, QC, Canada.
    Background: In the human electrocardiogram, there is a lag of adaptation of the QT interval to heart rate changes, usually termed QT/RR hysteresis (QT-hys). Subject-specific quantifiers of QT-hys have been proposed as potential biomarkers, but there is no consensus on the choice of the quantifier.

    Methods: A comprehensive literature search was conducted to identify original articles reporting quantifiers of repolarization hysteresis from the surface ECG in humans. Read More

    Conventional and right-sided screening for subcutaneous ICD in a population with congenital heart disease at high risk of sudden cardiac death.
    Ann Noninvasive Electrocardiol 2017 Nov 15;22(6). Epub 2017 May 15.
    Department of Cardiology, La Fe University Hospital, Valencia, Spain.
    Background: Information regarding suitability for subcutaneous defibrillator (sICD) implantation in tetralogy of Fallot (ToF) and systemic right ventricle is scarce and needs to be further explored. The main objective of our study was to determine the proportion of patients with ToF and systemic right ventricle eligible for sICD with both, standard and right-sided screening methods. Secondary objectives were: (i) to study sICD eligibility specifically in patients at high risk of sudden cardiac death, (ii) to identify independent predictors for sICD eligibility, and (iii) to compare the proportion of eligible patients in a nonselected ICD population. Read More

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