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    1 OF 48

    A prospective, multi-centre US clinical trial to determine accuracy of FebriDx point-of-care testing for acute upper respiratory infections with and without a confirmed fever.
    Ann Med 2018 May 18:1-10. Epub 2018 May 18.
    i Administrative , RPS Diagnostics , Sarasota , FL , USA.
    Background: FebriDx is a 10-minute disposable point-of-care test designed to identify clinically significant systemic host immune responses and aid in the differentiation of bacterial and viral respiratory infection by simultaneously detecting C-reactive protein (CRP) and myxovirus resistance protein A (MxA) from a fingerstick blood sample. FebriDx diagnostic accuracy was evaluated in the emergency room and urgent care setting.

    Methods: A prospective, multicentre, observational cohort study of acute upper respiratory tract infections (URIs), with and without a confirmed fever at the time of enrolment, was performed to evaluate the diagnostic accuracy of FebriDx to identify clinically significant bacterial infection with host response and acute pathogenic viral infection. Read More

    Effects of perioperative statins on patient outcomes after noncardiac surgery: a meta-analysis.
    Ann Med 2018 May 15:1-8. Epub 2018 May 15.
    b Department of Oncology , The Affiliated Hospital of Binzhou Medical University , Binzhou , Shandong , China.
    Background: Cardiovascular complications are strongly correlated with a higher risk of mortality during follow-up after noncardiac surgery. However, controversy remains regarding whether perioperative administration of hydroxymethylglutaryl-CoA reductase inhibitors (statins) has a beneficial effect on patient outcomes.

    Objective: We performed a meta-analysis to validate the hypothesis that perioperative statins improve patient outcomes after noncardiac surgery. Read More

    Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK biobank.
    Ann Med 2018 May 18:1-10. Epub 2018 May 18.
    d Institute of Health and Wellbeing , University of Glasgow , Glasgow , UK.
    Introduction: The risk of mortality from cardiovascular disease (CVD) is higher in wintertime throughout the world, but it is not known if this reflects annual changes in diet or lifestyle, or an endogenous photoperiodic mechanism that is sensitive to changes in day length.

    Methods: Phenotypic data on cardiometabolic and lifestyle factors were collected throughout a 4 year time period from 502,642 middle-aged participants in UK Biobank. To assess the impact of seasonal environmental changes on cardiovascular risk factors, we linked these data to the outdoor temperature and day length at the time of assessment. Read More

    Current evidence of peripheral vestibular symptoms secondary to otitis media.
    Ann Med 2018 May 6:1-11. Epub 2018 May 6.
    a Department of Otorhinolaryngology, Head and Neck Surgery , Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM) , São Paulo , Brazil.
    Background: The association between otitis media and vestibular symptoms has been hypothesized in the past. Thus, in this study, we aimed to critically analyze (based in a systematic review of the literature) whether patients who have otitis media are at greater risk of developing vestibular impairment or not.

    Methods: We performed a systematic review of the literature and identified potentially relevant articles reporting vestibular symptoms and results of vestibular function tests in patients with otitis media through searches of the PubMED, Web of Science, Scopus, and Google Scholar databases. Read More

    Metabolic syndrome is associated with hearing loss among a middle-aged and older Chinese population: a cross-sectional study.
    Ann Med 2018 May 9:1-9. Epub 2018 May 9.
    a Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health , School of Public Health, Huazhong University of Science and Technology , Wuhan , China.
    Background: Although the association of metabolic syndrome (MetS) and hearing loss has been evaluated, findings are controversial. This study investigated this association in a Chinese population.

    Methods: A cross-sectional study including a total of 18,824 middle-aged and older participants from the Dongfeng-Tongji Cohort study was conducted. Read More

    Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status.
    Ann Med 2018 Jun 30;50(4):333-344. Epub 2018 Apr 30.
    a Department of Oral and Maxillofacial Diseases , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.
    Objective: To study prospectively the association of salivary and serum matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1 and interleukin (IL)-6 with periodontal and systemic inflammation in rheumatoid arthritis (RA). We hypothesized that biomarker concentrations reflect inflammation.

    Methods: Fifty three early untreated RA (ERA) and 28 chronic RA (CRA) patients, underwent rheumatological and dental examinations at baseline and one year later after starting first conventional or biological disease modifying antirheumatic drug. Read More

    AFM as a tool to evaluate the risk for cardiovascular diseases in patients.
    Ann Med 2018 ;50(sup1):S1-S9
    a Instituto de Medicina Molecular, Faculdade de Medicina , Universidade de Lisboa , Portugal.
    Erythrocyte aggregation is an indicator of cardiovascular risk, which is influenced by plasma fibrinogen concentration. Fibrinogen levels are elevated during cardiovascular diseases. Our main goals were to understand how fibrinogen-erythrocyte binding influences erythrocyte aggregation and how it constitutes a cardiovascular risk factor in essential arterial hypertension (EAH) and chronic heart failure (CHF). Read More

    Prevalence of metabolic syndrome among middle-aged and elderly adults in China: current status and temporal trends.
    Ann Med 2018 Jun 21;50(4):345-353. Epub 2018 Apr 21.
    a Department of Social Medicine and Health Management, School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , P. R. China.
    Background: Metabolic syndrome (MetS) is a cluster of major risk factors for cardiovascular diseases. We aimed to estimate prevalence and distribution of MetS among middle-aged and elderly adults in China.

    Methods: The present analysis used data from a national study in 2014-2015. Read More

    Adult hospital admissions associated with multiple sclerosis in Finland in 2004-2014.
    Ann Med 2018 Jun 17;50(4):354-360. Epub 2018 Apr 17.
    e Heart Center , Turku University Hospital , Turku , Finland.
    Introduction: Treatment of multiple sclerosis (MS) has developed significantly and several new immunotherapeutic drugs have become available in Finland since 2004. We studied whether this is associated with changes in hospital admission frequencies and healthcare costs and whether admission rates due to infection have increased.

    Methods: The national Care Register for Health Care was searched for all discharges from neurological, medical, surgical, neurosurgical and intensive care units with MS as a primary diagnosis or an auxiliary diagnosis for primary infection diagnosis in 2004-2014. Read More

    Why all randomised controlled trials produce biased results.
    Ann Med 2018 Jun 4;50(4):312-322. Epub 2018 Apr 4.
    a London School of Economics ; University College London , London , UK.
    Background: Randomised controlled trials (RCTs) are commonly viewed as the best research method to inform public health and social policy. Usually they are thought of as providing the most rigorous evidence of a treatment's effectiveness without strong assumptions, biases and limitations.

    Objective: This is the first study to examine that hypothesis by assessing the 10 most cited RCT studies worldwide. Read More

    Fitting the right non-vitamin K antagonist oral anticoagulant to the right patient with non-valvular atrial fibrillation: an evidence-based choice.
    Ann Med 2018 Jun 15;50(4):288-302. Epub 2018 Apr 15.
    a Institute of Cardiovascular Sciences , University of Birmingham , Birmingham , UK.
    Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with an increased risk of ischemic stroke (IS) and systemic embolism (SE). Stroke prevention is a key element for the overall management of AF patients. The non-vitamin K antagonist oral anticoagulants (NOACs), such as dabigatran, rivaroxaban, apixaban and edoxaban, are at least as effective as warfarin in reducing IS/SE with a lower rate of major bleeding. Read More

    Molecular aspects of hypercholesterolemia treatment: current perspectives and hopes.
    Ann Med 2018 Jun 10;50(4):303-311. Epub 2018 Apr 10.
    e Medical Genetics Research Centre, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.
    Hypercholesterolemia is a pathological condition which has been reported in 39% of the worlds' adult population. We aimed to review molecular aspects of current and novel therapeutic approaches based on low-density lipoprotein cholesterol lowering strategies. Pathogenic mutations in the LDLR, ApoB, PCSK9 and LDLRAP genes cause deficient clearance of circulating low-density lipoprotein cholesterol particles via hepatic LDL receptor. Read More

    Pancreatic cancer subtypes: a roadmap for precision medicine.
    Ann Med 2018 Jun 22;50(4):277-287. Epub 2018 Mar 22.
    a Department of Medicine , University of Illinois at Chicago , Chicago , IL , USA.
    Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cause of cancer-related deaths by 2020. Although it has traditionally been approached as a disease, accumulated evidences point to the clinical heterogeneity of this disease, which translate into disparity in outcomes among the patients. Much emphasis has been put into patient classification introducing a platform for more tailored therapies. Read More

    Deciphering metabonomics biomarkers-targets interactions for psoriasis vulgaris by network pharmacology.
    Ann Med 2018 Jun 23;50(4):323-332. Epub 2018 Mar 23.
    a The Second Institute of Clinical Medicine , Guangzhou University of Chinese Medicine , Guangzhou , China.
    Objectives: Psoriasis vulgaris is a chronic inflammatory and immune-mediated skin disease. 44 metabonomics biomarkers were identified by high-throughput liquid chromatography coupled to mass spectrometry in our previous work, but the roles of metabonomics biomarkers in the pathogenesis of psoriasis is unclear.

    Methods: The metabonomics biomarker-enzyme network was constructed. Read More

    Hereditary angioedema due to C1-inhibitor deficiency in Macedonia: clinical characteristics, novel SERPING1 mutations and genetic factors modifying the clinical phenotype.
    Ann Med 2018 May 15;50(3):269-276. Epub 2018 Mar 15.
    b University Clinic of Respiratory and Allergic Diseases Golnik , Golnik , Slovenia.
    Objective: Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease, characterized by swellings. We aimed to characterize on a clinical and molecular basis C1-INH-HAE patients in the Republic of Macedonia.

    Results: All 15 patients from six unrelated families were diagnosed with C1-INH-HAE type I, with a mean age of symptom onset of 11 years and an average delay of diagnosis of seven years. Read More

    Contribution of non-traditional lipid profiles to reduced glomerular filtration rate in H-type hypertension population of rural China.
    Ann Med 2018 May 28;50(3):249-259. Epub 2018 Feb 28.
    a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , People's Republic of China.
    Background: Despite current interest in the unfavourable impact of non-traditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated.

    Methods: Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric and blood pressure values. Reduced GFR was considered if meeting estimated GFR <60 ml/min/1. Read More

    Glucocorticoid sensitivity and inflammatory status of peripheral blood mononuclear cells in patients with coronary artery disease.
    Ann Med 2018 May 28;50(3):260-268. Epub 2018 Feb 28.
    a Department of Medical and Health Sciences, Division of Cardiovascular Medicine , Linköping University , Linköping , Sweden.
    Objective: Mechanisms behind sustained inflammation in patients with coronary artery disease (CAD) are not clarified but hypothalamus-pituitary-adrenal (HPA) axis dysfunction may have a role. Here, we investigated whether inflammatory status of peripheral blood mononuclear cells (PBMCs) was associated with altered glucocorticoid sensitivity in CAD patients.

    Methods: In 55 CAD patients and 30 controls, mRNA levels of GR-α, GR-β, NF-κB, IκBα, MMP-9 and TIMP-1 were measured in PBMCs. Read More

    Relapse of bullous pemphigoid: an update on this stubborn clinical problem.
    Ann Med 2018 May 26;50(3):234-239. Epub 2018 Feb 26.
    a Department of Dermatology , Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China.
    Bullous pemphigoid (BP) is a chronic autoimmune blistering disorder that has a predilection for the elderly. It is characterized by a poor prognosis due to its high mortality rate and the tendency to relapse. The relapse rate of BP ranges from 27. Read More

    Inverse association between serum albumin and future risk of venous thromboembolism: interrelationship with high sensitivity C-reactive protein.
    Ann Med 2018 May 20;50(3):240-248. Epub 2018 Feb 20.
    e Institute of Public Health and Clinical Nutrition , University of Eastern Finland , Kuopio , Finland.
    Purpose: We aimed to assess the prospective association of serum albumin with venous thromboembolism (VTE) risk and evaluate if the association is independent of or modified by inflammation, as measured by high sensitivity C-reactive protein (hsCRP).

    Design: We analysed data of 2176 men aged 42-61 years free from VTE in the Kuopio Ischemic Heart Disease study, with serum albumin concentrations measured at baseline using Coulter's bromocresol purple colorimetric assays. Hazard ratios (HRs) (95% confidence intervals [CI]) were calculated for VTE. Read More

    Pulmonary hypertension and exercise training: a synopsis on the more recent evidences.
    Ann Med 2018 May 30;50(3):226-233. Epub 2018 Jan 30.
    f Cardiology Division , Santa Maria della Stella Hospital , Orvieto , Italy.
    The benefits of exercise training in virtually all humans, including those with a clinically stable chronic disease are numerous. The potential value lies in the fact that functional capacity is oftentimes significantly compromised. Exercise training not only play a role in reversing some of the pathophysiologic processes associated with chronic diseases but also improves clinical trajectory. Read More

    Challenges in adult vaccination.
    Ann Med 2018 May 16;50(3):181-192. Epub 2018 Jan 16.
    c Department of Medical Affairs , GlaxoSmithKline , Wavre , Belgium.
    Life-long primary prevention interventions beginning and continuing throughout an individual's lifetime are increasingly seen as key to meeting the global healthcare challenges that accompany demographic changes - a concept referred to as "Healthy aging". In this perspective, vaccination is seen as part of a triad, together with healthy diet and exercise. Current adult vaccine coverage is lower than target vaccination rates in most developed countries, and so vaccine preventable diseases continue to present a substantial burden on health and healthcare resources, especially in older individuals. Read More

    On surmounting the barriers to HPV vaccination: we can do better.
    Ann Med 2018 May 22;50(3):209-225. Epub 2018 Jan 22.
    a Department of Medicine , Drexel University College of Medicine , Philadelphia , PA , USA.
    The major impediment to increased human papillomavirus (HPV) vaccination coverage in young males and females is lack of health care provider recommendation. Despite its efficacy in preventing cervical cancer, HPV vaccination in females (49.5%) and males (37. Read More

    Maternal immunization: where are we now and how to move forward?
    Ann Med 2018 May 17;50(3):193-208. Epub 2018 Jan 17.
    a R&D Department , GSK , Wavre , Belgium.
    Pregnancy and the postpartum period are associated with elevated risks to both mother and infant from infectious disease. Vaccination of pregnant women, also called maternal immunization, has the potential to protect pregnant women, foetuses and infants from several vaccine-preventable diseases. Maternal immunoglobulin G antibodies are actively transferred through the placenta to provide passive immunity to new-borns during the first months of life, until the time for infant vaccinations or until the period of greatest susceptibility has passed. Read More

    Longer time spent in bed attempting to sleep is associated with rapid renal function decline: the Dongfeng-Tongji cohort study.
    Ann Med 2018 Mar 4;50(2):172-179. Epub 2018 Jan 4.
    a Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , China.
    Introduction: Prospective evidence on the relation between time in bed and renal dysfunction remains limited. We aimed to investigate the association of time spent in bed attempting to sleep (TSBS) with renal function decline in a middle-aged and elderly Chinese population.

    Methods: About 16,733 eligible participants with a mean age of 62. Read More

    The role of mitochondrial dysfunction in cardiovascular disease: a brief review.
    Ann Med 2018 Mar 18;50(2):121-127. Epub 2017 Dec 18.
    e Laboratory of Angiopathology , Institute of General Pathology and Pathophysiology, Russian Academy of Sciences , Moscow , Russia.
    Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Proper mitochondrial function is necessary in tissues and organs that are of high energy demand, including the heart. Mitochondria are very sensitive to nutrient and oxygen supply and undergo metabolic adaptation to the changing environment. Read More

    Autoimmune rheumatic diseases and the risk of Parkinson disease: a nationwide population-based cohort study in Taiwan.
    Ann Med 2018 Feb 20;50(1):83-90. Epub 2017 Dec 20.
    h Biostatistics Center and School of Health Care Administration, College of Management , Taipei Medical University , Taipei , Taiwan.
    Backgrounds: In autoimmune rheumatic diseases (ARDs), the levels of inflammatory mediators are increased and microglia may be activated, resulting in an inflammatory state and the degeneration of dopaminergic neurons. We investigated the association between ARDs and Parkinson disease (PD).

    Methods: We identified ARD patients through the Taiwan National Health Insurance Research Database from 2001 to 2012. Read More

    Mortality in patients with atrial fibrillation and common co-morbidities - a cohort study in primary care.
    Ann Med 2018 Mar 27;50(2):156-163. Epub 2017 Nov 27.
    f Center for Primary Health Care Research, Lund University , Malmö , Sweden.
    Objective: To study the association between cardiovascular co-morbidities and mortality risk in primary care patients with atrial fibrillation.

    Methods: The study population included all adults (n = 12,283) ≥ 45 years diagnosed with AF at 75 primary care centres in Sweden between 2001 and 2007. The outcome was mortality (until 2010) and data were explored for co-morbidities using Cox regression with hazard ratios (HRs). Read More

    Understanding modern-day vaccines: what you need to know.
    Ann Med 2018 Mar 27;50(2):110-120. Epub 2017 Nov 27.
    d Department of Family and Community Medicine , University of Toronto , Toronto , Canada.
    Vaccines are considered to be one of the greatest public health achievements of the last century. Depending on the biology of the infection, the disease to be prevented, and the targeted population, a vaccine may require the induction of different adaptive immune mechanisms to be effective. Understanding the basic concepts of different vaccines is therefore crucial to understand their mode of action, benefits, risks, and their potential real-life impact on protection. Read More

    Pharmacological interventions for preventing acute mountain sickness: a network meta-analysis and trial sequential analysis of randomized clinical trials.
    Ann Med 2018 Mar 23;50(2):147-155. Epub 2017 Nov 23.
    b School of Oral Health, College of Medicine, Nursing and Health Sciences , Fiji National University , Suva , Fiji.
    Background: Individuals ascending to high altitude are at a risk of getting acute mountain sickness (AMS). The present study is a network meta-analysis comparing all the interventions available to prevent AMS.

    Methods: Electronic databases were searched for randomized clinical trials evaluating the use of drugs to prevent AMS. Read More

    Clinical manifestations and outcomes of severe warfarin overanticoagulation: from the EWA study.
    Ann Med 2018 Mar 23;50(2):164-171. Epub 2017 Nov 23.
    a Heart Center , Turku University Hospital and University of Turku , Turku , Finland.
    Introduction: Severe warfarin overanticoagulation is a risk factor for bleeding, but there is little information on its manifestations, prognosis and factors affecting the outcome. We describe the manifestations and clinical outcomes of severe warfarin overanticoagulation in a large group of patients with atrial fibrillation (AF).

    Material And Methods: All international normalized ratio (INR) samples (n = 961,431) in the Turku University Hospital region between 2003 and 2015 were screened. Read More

    Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study.
    Ann Med 2018 Feb 7;50(1):74-82. Epub 2017 Nov 7.
    b Research Centre of Applied and Preventive Cardiovascular Medicine , University of Turku , Turku , Finland.
    Objectives: To determine whether vitamin D status in childhood and adolescence (herein collectively referred to as youth) and the long-term status from youth to adulthood is associated with risk of developing type 2 diabetes mellitus (T2DM) and impaired fasting glucose (IFG) in adulthood.

    Materials And Methods: This was a 31-year follow-up study of 2300 participants aged 3-18 years. Multinomial logistic regression was used to assess the association of both (a) baseline 25-hydroxyvitamin D (25OHD) levels and (b) the mean of baseline and the latest follow-up 25OHD levels (continuous variable and quartiles) with incident T2DM and IFG (cut-off = 5. Read More

    Next generation sequencing applications for cardiovascular disease.
    Ann Med 2018 Mar 26;50(2):91-109. Epub 2017 Oct 26.
    a Cardiogenetic Research Laboratory , Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences , Tehran , Iran.
    The Human Genome Project (HGP), as the primary sequencing of the human genome, lasted more than one decade to be completed using the traditional Sanger's method. At present, next-generation sequencing (NGS) technology could provide the genome sequence data in hours. NGS has also decreased the expense of sequencing; therefore, nowadays it is possible to carry out both whole-genome (WGS) and whole-exome sequencing (WES) for the variations detection in patients with rare genetic diseases as well as complex disorders such as common cardiovascular diseases (CVDs). Read More

    Effect of age, period and birth-cohort on the frequency of glucose-6-phosphate dehydrogenase deficiency in Sardinian adults.
    Ann Med 2018 Feb 16;50(1):68-73. Epub 2017 Oct 16.
    a Dipartimento di Medicina Clinica e Sperimentale , University of Sassari , Sassari , Italy.
    Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder common in Sardinia. In this study, the frequency variation of G6PD-deficiency across age groups and birth cohorts was investigated using Age-Period-Cohort analysis.

    Methods: Data were collected from the clinical records of 11,252 patients (6975 women, age range 17-94 years) who underwent endoscopy between 2000 and 2016 at a teaching hospital (University of Sassari), Italy. Read More

    Mechanical dispersion is associated with poor outcome in heart failure with a severely depressed left ventricular function and bundle branch blocks.
    Ann Med 2018 Mar 13;50(2):128-138. Epub 2017 Oct 13.
    a Department of Cardiology, Clinical Hospital Center Zemun, Faculty of Medicine , University of Belgrade , Belgrade , Serbia.
    Objectives: Bundle branch blocks (BBB)-related mechanical dyssynchrony and dispersion may improve patient selection for device therapy, but their effect on the natural history of this patient population is unknown.

    Methods: A total of 155 patients with LVEF ≤ 35% and BBB, not treated with device therapy, were included. Mechanical dyssynchrony was defined as the presence of either septal flash or apical rocking. Read More

    Joint associations of sauna bathing and cardiorespiratory fitness on cardiovascular and all-cause mortality risk: a long-term prospective cohort study.
    Ann Med 2018 Mar 16;50(2):139-146. Epub 2017 Oct 16.
    c Institute of Public Health and Clinical Nutrition , University of Eastern Finland , Kuopio , Finland.
    Purpose: We aimed to evaluate the joint impact of cardiorespiratory fitness (CRF) and frequency of sauna bathing (FSB) on the risk of cardiovascular and all-cause mortality.

    Design: CRF measured by respiratory gas analyses and sauna exposure were assessed at baseline in a prospective study of 2277 men. CRF was categorized as low and high (median cut-offs) and FSB as low and high (≤2 and 3-7 sessions/week, respectively). Read More

    The role of levothyroxine in obstetric practice.
    Ann Med 2018 Feb 11;50(1):57-67. Epub 2017 Oct 11.
    b Thyroid Research Group , Systems Immunity Research Institute, Cardiff University School of Medicine , Cardiff , UK.
    Thyroid hormones play a pivotal role in somatic growth, metabolic regulation and neurodevelopment. There is growing evidence regarding adverse obstetric and perinatal consequences of maternal thyroid hypofunction during early stages of pregnancy. These include: early pregnancy loss, preterm delivery and lower intelligence quotient (IQ) in children. Read More

    Genetic and ethnic modulation of cardiovascular toxicity of vascular endothelial growth factor inhibitors.
    Ann Med 2018 Feb 27;50(1):46-56. Epub 2017 Sep 27.
    a Division of Cardiovascular Medicine, Department of Internal Medicine , Wan Fang Hospital, Taipei Medical University , Taipei , Taiwan.
    Vascular endothelial growth factor (VEGF) inhibitors, including monoclonal antibodies and tyrosine kinase inhibitors (TKIs), are important as anticancer treatments through curbing tumour angiogenesis and growth. VEGF inhibitors have significant cardiovascular effects. By blocking VEGF receptors, ligands, or signal pathways, VEGF inhibitors disturb the balance between vasodilation and vasoconstriction, undermine endothelial cell integrity, and activate cardiomyocyte apoptosis. Read More

    Case fatality of acute coronary events is improving even among elderly patients; the FINAMI study 1995-2012.
    Ann Med 2018 Feb 3;50(1):35-45. Epub 2017 Oct 3.
    c Department of Health , National Institute for Health and Welfare (THL) , Helsinki , Finland.
    Aim: To examine trends in incidence and 28-day case fatality of myocardial infarction (MI) in persons aged 75-99 years in four areas of Finland.

    Methods And Results: The Finnish Acute Myocardial Infarction (FINAMI) register is a population-based MI register study, which during 1995-2012 recorded 30561 suspected acute coronary syndromes in persons aged ≥75 years. Of them, 16229 fulfilled the American Heart Association criteria for a definite, probable or possible MI or coronary death. Read More

    Enhancing the 'real world' prediction of cardiovascular events and major bleeding with the CHADS-VASc and HAS-BLED scores using multiple biomarkers.
    Ann Med 2018 Feb 18;50(1):26-34. Epub 2017 Sep 18.
    b Institute of Cardiovascular Sciences , University of Birmingham , Birmingham , UK.
    Background: Atrial fibrillation (AF)-European guidelines suggest the use of biomarkers to stratify patients for stroke and bleeding risks. We investigated if a multibiomarker strategy improved the predictive performance of CHADS-VASc and HAS-BLED in anticoagulated AF patients.

    Methods: We included consecutive patients stabilized for six months on vitamin K antagonists (INRs 2. Read More

    Direct, indirect and total bilirubin and risk of incident coronary heart disease in the Dongfeng-Tongji cohort.
    Ann Med 2018 Feb 18;50(1):16-25. Epub 2017 Sep 18.
    a Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection and State Key Laboratory of Environmental Health (Incubating), School of Public Health , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
    Background: Total bilirubin (TBIL) is known to be inversely associated with coronary heart disease (CHD) risk, however, whether this association is dose-response remains inconsistent and it is unclear which subtype of bilirubin is responsible for the potential protective effect.

    Methods: We included 12,097 participants who were free of CHD, stroke, cancer and potential liver, biliary and renal diseases at baseline from September 2008 to June 2010 and were followed-up until October 2013. Cox proportional hazards models were used to assess the hazard ratios (HR) and 95% confidence interval (95% CI) of bilirubin with incident CHD risk. Read More

    Baseline fatty acids, food groups, a diet score and 50-year all-cause mortality rates. An ecological analysis of the Seven Countries Study.
    Ann Med 2017 Dec 6;49(8):718-727. Epub 2017 Sep 6.
    d Division of Epidemiology and Community Health, School of Public Health , University of Minnesota , Minneapolis , MN , USA.
    Objectives: This analysis deals with the ecologic relationships of dietary fatty acids, food groups and the Mediterranean Adequacy Index (MAI, derived from 15 food groups) with 50-year all-cause mortality rates in 16 cohorts of the Seven Countries Study.

    Material And Methods: A dietary survey was conducted at baseline in cohorts subsamples including chemical analysis of food samples representing average consumptions. Ecologic correlations of dietary variables were computed across cohorts with 50-year all-cause mortality rates, where 97% of men had died. Read More

    A clinical decision-making algorithm for penicillin allergy.
    Ann Med 2017 Dec 26;49(8):710-717. Epub 2017 Aug 26.
    a Department of Dermatology and Allergology , Tenon Hospital, APHP , Paris , France.
    Background: About 10% of subjects report suspected penicillin allergy, but 85-90% of these patients are not truly allergic and could safely receive beta-lactam antibiotics Objective: To design and validate a clinical decision-making algorithm, based on anamnesis (chronology, severity, and duration of the suspected allergic reactions) and reaching a 100% sensitivity and negative predictive value, to assess allergy risk related to a penicillin prescription in general practise.

    Study Design And Methods: All patients were included prospectively and explorated based on ENDA/EAACI recommendations. Results of penicillin allergy work-up (gold standard) were compared with results of the algorithm. Read More

    Oxygen uptake at aerobic threshold is inversely associated with fatal cardiovascular and all-cause mortality events.
    Ann Med 2017 Dec 22;49(8):698-709. Epub 2017 Aug 22.
    b Institute of Public Health and Clinical Nutrition , University of Eastern Finland , Kuopio , Finland.
    Purpose: We aimed to assess the associations of oxygen uptake at aerobic threshold (VO at AT) with cardiovascular and all-cause mortality.

    Design: VO at AT was assessed in 1663 middle-aged men in a cohort study. Hazard ratios (HRs) were calculated for sudden cardiac death (SCD), fatal coronary heart disease (CHD) and cardiovascular disease (CVD) and all-cause mortality. Read More

    Role of lipids and intraplaque hypoxia in the formation of neovascularization in atherosclerosis.
    Ann Med 2017 Dec 22;49(8):661-677. Epub 2017 Aug 22.
    b Laboratory of Angiopathology , Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences , Moscow , Russia.
    According to the current paradigm, chronic vascular inflammation plays a central role in the pathogenesis of atherosclerosis. The plaque progression is typically completed with rupture and subsequent acute cardiovascular complications. Previously, the role of adventitial vasa vasorum in atherogenesis was underestimated. Read More

    Nutraceutical approaches to metabolic syndrome.
    Ann Med 2017 Dec 22;49(8):678-697. Epub 2017 Aug 22.
    c Dipartimento di Scienze Farmacologiche e Biomolecolari , Università degli Studi di Milano , Milan , Italy.
    Metabolic Syndrome (MetS), affecting at least 30% of adults in the Western World, is characterized by three out of five variables, from high triglycerides, to elevated waist circumference and blood pressure. MetS is not characterized by elevated cholesterolemia, but is rather the consequence of a complex interaction of factors generally leading to increased insulin resistance. Drug treatments are of difficult handling, whereas well-characterized nutraceuticals may offer an effective alternative. Read More

    PDTCM: a systems pharmacology platform of traditional Chinese medicine for psoriasis.
    Ann Med 2017 Dec 24;49(8):652-660. Epub 2017 Aug 24.
    a The Second Institute of Clinical Medicine , Guangzhou University of Chinese Medicine , Guangzhou , China.
    Introduction: Psoriasis is a refractory skin disorder, and usually requires a lifetime control. Traditional Chinese medicine (TCM) is effective and safe for this disease. However, the cellular and molecular mechanisms of TCM remedies for psoriasis are still not fully understood. Read More

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