2,485 results match your criteria Annals of Medicine[Journal]


Differential biomarker profiles between unprovoked venous thromboembolism and cancer.

Ann Med 2020 Jul 7:1-26. Epub 2020 Jul 7.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Seville, Spain.

Background: The relationship between cancer and venous thromboembolic disease (VTD) are complex because the activated coagulation factors are not only involved in thrombosis, but also in malignant processes, such as angiogenesis and metastasis.

Objective: To compare phenotypes of extracellular vesicles (EVs), and levels of D-dimer, soluble P-selectin (sP-selectin) and antigenic tissue factor (TF) between unprovoked VTD patients, who did not develop cancer during one year follow-up, and those with advanced stage of cancer but not associated with VTD.

Methods: A prospective study in which we included 138 unprovoked VTD patients and 67 advanced cancer patients, who did not develop thrombosis. Read More

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http://dx.doi.org/10.1080/07853890.2020.1779956DOI Listing

Demographics, Comorbidities, and Outcomes in Hospitalized Covid-19 Patients in Rural Southwest Georgia.

Ann Med 2020 Jul 3:1-17. Epub 2020 Jul 3.

Department of Internal Medicine, University of Nevada Reno School of Medicine, Reno, NV, USA.

There is limited data on outcomes in patients with coronavirus disease 2019 (Covid-19) in rural United States (US). This study aimed to describe the demographics, and outcomes of hospitalized Covid-19 patients in rural Southwest Georgia. Using electronic medical records, we analyzed data from all hospitalized Covid-19 patients who either diedor survived to discharge between March 2, 2020 and May 6, 2020. Read More

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http://dx.doi.org/10.1080/07853890.2020.1791356DOI Listing

COVID-19 and venous thromboembolism: current insights and prophylactic strategies.

Ann Med 2020 Jul 3:1-13. Epub 2020 Jul 3.

Department of Translational Medical Sciences, Federico II University, Naples, Italy.

The rapidly increasing number of studies on the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicate that this viral agent can cause the coronavirus disease 2019 (COVID-19), a syndrome with a wide spectrum of clinical presentations, ranging from a mild disease with flu-like symptoms to a life-threatening condition that requires specialized management at Intensive Care Units (ICU). Critical patients with COVID-19 have a high risk of thromboembolic complications, as expressed by a Padua prediction score always ≥4. Moreover, a number of clinical factors may increase the risk of major bleedings in these patients during ICU stay. Read More

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http://dx.doi.org/10.1080/07853890.2020.1791355DOI Listing

24-h urinary sodium excretion and the risk of adverse outcomes.

Ann Med 2020 Jun 30:1-9. Epub 2020 Jun 30.

Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland.

: The objective was to evaluate whether sodium intake, assessed with the gold standard 24-h urinary collections, was related to long-term incidence of death, cardiovascular disease (CVD) and diabetes mellitus (DM). A cohort of 4630 individuals aged 25-64 years collected 24-h urine samples in 1979-2002 and were followed up to 14 years for the incidence of any CVD, coronary heart disease (CHD), stroke, heart failure (HF) and DM event, and death. Cox proportional hazards models were used to estimate the association between the baseline salt intake and incident events and adjusted for baseline age, body mass index, serum cholesterol, prevalent DM, and stratified by sex and cohort baseline year. Read More

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http://dx.doi.org/10.1080/07853890.2020.1780469DOI Listing

Effect of vaccination on the use of antimicrobial agents: a systematic literature review.

Ann Med 2020 Jun 29:1-17. Epub 2020 Jun 29.

Department of Clinical Microbiology, Landspitali University Hospital, Reykjavík, Iceland.

Antimicrobial resistance is a growing global health threat. To preserve the effectiveness of antimicrobials, it is important to reduce demand for antimicrobials. The objective of the study was to screen the existing peer-reviewed literature to identify articles that addressed the potential impact of influenza or vaccination on antibiotic usage. Read More

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http://dx.doi.org/10.1080/07853890.2020.1782460DOI Listing

Vasculitides and glomerulonephritis associated with infective endocarditis: cases reports and mini-review of the literature.

Ann Med 2020 Jun 26:1-10. Epub 2020 Jun 26.

Service de Médecine Interne, Hôpital Robert Debré, Reims, France.

We reported two cases of Infective Endocarditis associated with vasculitides and glomerulonephritis respectively, before conducting an online search of previously published similar cases reports. Twenty five references were selected: 15 cases of glomerulonephritis; 2 cases of vasculitis and 8 cases involving both glomerulonephritis and vasculitis. Vasculitides and glomerulonephritis associated with definite Infective Endocarditis have been reported since 1976. Read More

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http://dx.doi.org/10.1080/07853890.2020.1778778DOI Listing

Inverse time trends of peptic ulcer and reflux esophagitis show significant association with reduced prevalence of infection.

Ann Med 2020 Jun 22:1-9. Epub 2020 Jun 22.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Recent prevalence and trends of gastric/duodenal ulcer (GU/DU) and reflux esophagitis (RE) are inadequate. We reviewed the records of consecutive 211,347 general population subjects from 1991 to 2015. During the 25 years, the prevalence of GU and DU has gradually decreased (from 3. Read More

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http://dx.doi.org/10.1080/07853890.2020.1782461DOI Listing
June 2020
3.886 Impact Factor

NEWS and qSIRS superior to qSOFA in the prediction of 30-day mortality in emergency department patients in Hong Kong.

Ann Med 2020 Jun 25:1-10. Epub 2020 Jun 25.

Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Hong Kong SAR, China.

We aim to compare the prognostic value of Quick Sepsis-Related Organ Failure Assessment (qSOFA) and the previous Systemic Inflammatory Response Syndrome (SIRS) criteria, the National Early Warning Score (NEWS) and along with their combinations in the emergency department (ED). This single-centre prospective study recruited a convenience sample of unselected ED patients triaged as category 2 (Emergency) and 3 (Urgent). Receiver Operating Characteristic analyses were performed to determine the Area Under the Curve (AUC), along with sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios for the various scores. Read More

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http://dx.doi.org/10.1080/07853890.2020.1782462DOI Listing

Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition.

Ann Med 2020 Aug 10;52(5):147-161. Epub 2020 Jun 10.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.

In recent years a revival of interest has emerged in the health benefits of intermittent fasting and long-term fasting, as well as of other related nutritional strategies. In addition to meal size and composition a new focus on time and frequency of meals has gained attention. The present review will investigate the effects of the main forms of fasting, activating the metabolic switch from glucose to fat and ketones (G-to-K), starting 12-16 h after cessation or strong reduction of food intake. Read More

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http://dx.doi.org/10.1080/07853890.2020.1770849DOI Listing

Relationship of adverse events to quality of anticoagulation control in atrial fibrillation patients with diabetes: Real-world data from the FANTASIIA registry.

Ann Med 2020 Jun 5:1-22. Epub 2020 Jun 5.

Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, CIBERCV, Murcia, Spain.

Background: Atrial fibrillation (AF) patients with diabetes (DM) are at increased risk of cardiovascular events and have higher related morbidity and mortality.

Purpose: To compare clinical characteristics, cardiovascular adverse outcomes and quality of anticoagulation in AF patients with and without DM.

Methods: AF patients from the Spanish national, multicentric, prospective FANTASIIA registry were included. Read More

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http://dx.doi.org/10.1080/07853890.2020.1778176DOI Listing

Lipoprotein(a) in atherosclerosis: from pathophysiology to clinical relevance and treatment options.

Ann Med 2020 Aug 8;52(5):162-177. Epub 2020 Jun 8.

Department of Vascular Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Lipoprotein(a) (Lp(a)) was discovered more than 50 years ago, and a decade later, it was recognized as a risk factor for coronary artery disease. However, it has gained importance only in the past 10 years, with emergence of drugs that can effectively decrease its levels. Lp(a) is a low-density lipoprotein (LDL) with an added apolipoprotein(a) attached to the apolipoprotein B component a disulphide bond. Read More

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http://dx.doi.org/10.1080/07853890.2020.1775287DOI Listing

Clinical practice patterns in revascularization of diabetic patients with coronary heart disease: nationwide register study.

Ann Med 2020 Aug 2;52(5):225-232. Epub 2020 Jun 2.

THL - Finnish Institute for Health and Welfare, Helsinki, Finland.

To compare diabetic patients with coronary heart disease (CHD) needing revascularization to corresponding non-diabetic patients in terms of revascularization methods, comorbidities and urgency of procedure. We also examined the impact of patient characteristics and comorbidities on the revascularization method. We identified all diabetic ( = 33,018) and non-diabetic ( = 106,224) patients with first-ever, percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) from electronic health records in Finland between 2000 and 2015. Read More

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http://dx.doi.org/10.1080/07853890.2020.1771757DOI Listing

Role of sodium glucose co-transporter 2 inhibitors in patients with heart failure: an elusive mechanism.

Ann Med 2020 Aug 22;52(5):178-190. Epub 2020 May 22.

Cardiovascular Institute, Warren Alpert Medical School at Brown University, Providence, RI, USA.

Heart failure (HF) is a major cause of morbidity and mortality worldwide, and the burden of HF continues to rise. There has been an interest in sodium-glucose co-transporter-2 (SGLT2) inhibitors for their role in reducing HF hospitalizations in pivotal trials. Since these agents were approved by the Food and Drug Administration for the management of diabetes mellitus, multiple small trials and analyses have tried to explain the underlying beneficial mechanisms in HF . Read More

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http://dx.doi.org/10.1080/07853890.2020.1767298DOI Listing
August 2020
3.886 Impact Factor

Multi-tiered screening and diagnosis strategy for COVID-19: a model for sustainable testing capacity in response to pandemic.

Ann Med 2020 08 14;52(5):207-214. Epub 2020 May 14.

Lumos Diagnostics, Inc., Sarasota, FL, USA.

Coronavirus disease 2019 (COVID-19), caused by novel enveloped single stranded RNA coronavirus (SARS-CoV-2), is responsible for an ongoing global pandemic. While other countries deployed widespread testing as an early mitigation strategy, the U.S. Read More

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http://dx.doi.org/10.1080/07853890.2020.1763449DOI Listing

Prognostic value of myocardial injury-related findings on resting electrocardiography for cardiovascular risk in the asymptomatic general population: the 12-year follow-up report from the Ansan-Ansung cohort.

Ann Med 2020 Aug 28;52(5):215-224. Epub 2020 Apr 28.

Division of Cardiology, Department of Internal Medicine, Hanyang University Guri Hospital, Guri City, Republic of Korea.

We investigated the predictive values of myocardial injury-related findings (MIFs) including ST-T wave abnormalities (STA) and pathologic Q waves (PQ) in electrocardiography for long-term cardiovascular outcomes in an asymptomatic general population. We observed 8444 subjects without cardiovascular diseases and related symptoms biennially over a 12-year period. Major cardiovascular adverse events (MACEs) were defined as a composite of cardiovascular death, myocardial infarction, coronary artery disease and stroke. Read More

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http://dx.doi.org/10.1080/07853890.2020.1755052DOI Listing

Clinical significance of increased PML-RARa transcripts after induction therapy for acute promyelocytic leukaemia.

Ann Med 2020 Aug 23;52(5):233-238. Epub 2020 Apr 23.

Department of Hematology, Tongji Hospital, Tongji Medical College, Hua Zhong University of Science and Technology, Wu Han, Hubei, China.

To analyze the clinical and biological significance of the acute promyelocytic leukemia (APL) whose PML-RARa transcripts increased after induction therapy. We analyzed 9 cases of APL whose PML-RARa transcripts increased after induction treatment and compare them with APL whose PML-RARa transcripts decreased. The only factor affecting increased PML-RARa transcripts was the induction protocol. Read More

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http://dx.doi.org/10.1080/07853890.2020.1753886DOI Listing

Postpericardiotomy syndrome after cardiac surgery.

Ann Med 2020 May 2:1-22. Epub 2020 May 2.

Heart Center, Turku University Hospital, University of Turku, Turku, Finland.

Postpericardiotomy syndrome (PPS) is a well-known complication after cardiac surgery. The syndrome results in prolonged hospital stay, readmissions, and invasive interventions. Previous studies have reported inconsistent results concerning the incidence and risk factors for PPS due to the differences in the applied diagnostic criteria, study designs, patient populations, and procedure types. Read More

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http://dx.doi.org/10.1080/07853890.2020.1758339DOI Listing

Local ocular renin-angiotensin-aldosterone system: any connection with intraocular pressure? A comprehensive review.

Ann Med 2020 Aug 30;52(5):191-206. Epub 2020 Apr 30.

Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.

The renin-angiotensin system (RAS) is one of the oldest and most extensively studied human peptide cascades, well-known for its role in regulating blood pressure. When aldosterone is included, RAAS is involved also in fluid and electrolyte homeostasis. There are two main axes of RAAS: (1) Angiotensin (1-7), angiotensin converting enzyme 2 and Mas receptor (ACE2-Ang(1-7)-MasR), (2) Angiotensin II, angiotensin converting enzyme 1 and angiotensin II type 1 receptor (ACE1-AngII-AT1R). Read More

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http://dx.doi.org/10.1080/07853890.2020.1758341DOI Listing

Prospective cohort study of daily alcoholic beverage intake as a potential trigger of headaches among adults with episodic migraine.

Ann Med 2020 Apr 29:1-7. Epub 2020 Apr 29.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

To determine whether alcohol intake is associated with occurrence of headaches on the following day. In this prospective cohort study, adults with episodic migraine completed electronic diaries every morning and evening for at least six weeks in March 2016-October 2017. Every day, participants reported alcohol intake, lifestyle factors, and details about each headache. Read More

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http://dx.doi.org/10.1080/07853890.2020.1758340DOI Listing

The diagnostic value of magnetic resonance urography for detecting ureteric obstruction: A systematic review and meta-analysis.

Ann Med 2020 Apr 1:1-27. Epub 2020 Apr 1.

Department of Medical Imaging, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China.

To evaluate the diagnostic accuracy of MRU and determine its value for detecting ureteric obstruction. The electronic databases, including PubMed, Embase, and the Cochrane library, were systematically searched for studies published throughout September 2018. The summary of sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and receiver operating characteristic (ROC) curves were assessed to evaluate the diagnostic accuracy of MRU. Read More

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http://dx.doi.org/10.1080/07853890.2020.1741672DOI Listing

Handgrip strength is inversely associated with fatal cardiovascular and all-cause mortality events.

Ann Med 2020 May - Jun;52(3-4):109-119. Epub 2020 Apr 9.

National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK.

We aimed to assess the associations of handgrip strength (HS) with cardiovascular and all-cause mortality and whether adding data on HS to cardiovascular disease (CVD) risk factors is associated with improvement in CVD mortality prediction. Handgrip strength was assessed in a population-based sample of 861 participants aged 61-74 years at baseline. Relative HS was obtained by dividing the absolute value by body weight. Read More

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http://dx.doi.org/10.1080/07853890.2020.1748220DOI Listing
April 2020
3.886 Impact Factor

Associations of serum sclerostin with bone mineral density, markers of bone metabolism and thalassaemia characteristics in adult patients with transfusion-dependent beta-thalassaemia.

Ann Med 2020 May - Jun;52(3-4):94-108. Epub 2020 Mar 26.

Clinic of Clinical Hematology, University Hospital "Sv. Georgi", Plovdiv, Bulgaria.

To assess serum sclerostin in transfusion-dependent beta-thalassaemia patients versus healthy controls and to examine its associations with bone mineral density, bone metabolism markers and beta thalassaemia alterations. Sixty-two transfusion-dependent beta-thalassaemia (TDßT) patients and 30 healthy controls were evaluated for serum sclerostin, osteocalcin, beta-cross laps, osteoprotegerin and serum level of receptor activator of nuclear factor kappa-Β ligand (sRANKL). Bone mineral density was measured at the lumbar spine and femoral neck. Read More

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http://dx.doi.org/10.1080/07853890.2020.1744708DOI Listing

Comparison of inhaled nitric oxide with aerosolized prostacyclin or analogues for the postoperative management of pulmonary hypertension: a systematic review and meta-analysis.

Ann Med 2020 May - Jun;52(3-4):120-130. Epub 2020 Apr 2.

Department of Anesthesiology, National Taiwan University Hospital, Taipei City, Taiwan.

This study aims to compare the effectiveness of inhaled prostacyclin or its analogues nitric oxide (NO) in treating pulmonary hypertension (PH) after cardiac or pulmonary surgery remains unclear. PubMed, Cochrane, and Embase databases were searched for literature published prior to December 2019 using the following keywords: inhaled, nitric oxide, prostacyclin, iloprost, treprostinil, epoprostenol, Tyvaso, flolan, and pulmonary hypertension. Randomized controlled trials and multiple-armed prospective studies that evaluated inhaled NO prostacyclin (or analogues) in patients for perioperative and/or postoperative PH after either cardiac or pulmonary surgery were included. Read More

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http://dx.doi.org/10.1080/07853890.2020.1746826DOI Listing

Response to commentary by Lu and Wang on "Salivary biomarkers for cancer diagnosis: a meta-analysis".

Ann Med 2020 May - Jun;52(3-4):146. Epub 2020 Apr 2.

Liquid Biopsy Analysis Unit, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain.

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http://dx.doi.org/10.1080/07853890.2020.1746391DOI Listing

Commentary on: Salivary biomarkers for cancer diagnosis: a meta-analysis.

Authors:
Yuanxi Lu Qiwu Wang

Ann Med 2020 May - Jun;52(3-4):145. Epub 2020 Mar 22.

Department of Cardiology, Nanning Second Peoples Hospital, the Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

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http://dx.doi.org/10.1080/07853890.2020.1743351DOI Listing

Factors associated with the activity and severity of bullous pemphigoid: a review.

Ann Med 2020 May - Jun;52(3-4):55-62. Epub 2020 Mar 22.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.

Bullous pemphigoid (BP) is the most common subepidermal autoimmune blistering disease. It usually affects people older than 70 years of age. The two main autoantigens are BP180 and BP230, both of which are components of hemidesmosomes. Read More

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http://dx.doi.org/10.1080/07853890.2020.1742367DOI Listing
March 2020
3.886 Impact Factor

Peptide hormones and risk for future cardiovascular events among prediabetics: a 20-year follow-up in the OPERA study.

Ann Med 2020 May - Jun;52(3-4):85-93. Epub 2020 Mar 22.

Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.

Prediabetes has proven to have many unfavourable impacts on the cardiovascular system. The OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study included 1045 middle-aged subjects followed from the years 1990-1993 to 2014. The focus was on peptide hormones. Read More

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http://dx.doi.org/10.1080/07853890.2020.1741673DOI Listing

Poor adherence to beta-blockers is associated with increased long-term mortality even beyond the first year after an acute coronary syndrome event.

Ann Med 2020 May - Jun;52(3-4):74-84. Epub 2020 Mar 17.

Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland.

: Acute coronary syndrome (ACS) patients are widely treated with long-term beta-blocker therapy after cardiac event. Especially for low-risk patients, the benefits of beta-blockers on survival and the optimal therapy duration remain unclear. We investigated the effect of adherence to beta-blockers on long-term survival of ACS patients. Read More

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http://dx.doi.org/10.1080/07853890.2020.1740938DOI Listing

Longitudinal blood pressure patterns and cardiovascular disease risk.

Ann Med 2020 May - Jun;52(3-4):43-54. Epub 2020 Mar 13.

Division of Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Observational and interventional studies have unequivocally demonstrated that "present", i.e. single-occasion, blood pressure is one of the key determinants of cardiovascular disease risk. Read More

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http://dx.doi.org/10.1080/07853890.2020.1733648DOI Listing

The prevalence and prognostic significance of interatrial block in the general population.

Ann Med 2020 May - Jun;52(3-4):63-73. Epub 2020 Mar 14.

Faculty of Medicine and Health Technology, Tampere University and Finnish Cardiovascular Research Center, Tampere, Finland.

Partial and advanced interatrial block (IAB) in the electrocardiographic (ECG) represents inter-atrial conduction delay. IAB is associated with atrial fibrillation (AF) and stroke in the general population. A representative sample of Finnish subjects ( = 6354) aged over 30 years (mean: 52. Read More

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http://dx.doi.org/10.1080/07853890.2020.1731759DOI Listing

Salivary biomarkers for cancer diagnosis: a meta-analysis.

Ann Med 2020 May - Jun;52(3-4):131-144. Epub 2020 Apr 11.

Liquid Biopsy Analysis Unit, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain.

Saliva represents a promising non-invasive source of novel biomarkers for diagnosis and prognosis cancer. This meta-analysis evaluates the diagnostic value of salivary biomarkers for detection of malignant non-oral tumours to better define the value of saliva as an alternative liquid biopsy. We performed a systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1080/07853890.2020.1730431DOI Listing

Association of rheumatoid arthritis disease activity and antibodies to periodontal bacteria with serum lipoprotein profile in drug naive patients.

Ann Med 2020 Feb - Mar;52(1-2):32-42. Epub 2020 Feb 10.

Department of Medicine, Kuopio University Hospital, Kuopio, Finland.

We investigated lipid concentrations, particle sizes and antibodies binding to periodontal bacteria and and to malondialdehyde-acetaldehyde (MAA) modified low-density lipoprotein in immunoglobulin (Ig) class A, G and M among patients with newly diagnosed rheumatoid arthritis (RA) in a population-based cohort. Concentrations and sizes of lipoprotein particles analysed by proton nuclear magnetic resonance spectroscopy and antibody levels to MAA modified low-density lipoprotein were studied at baseline and after one-year of follow-up. Serum Ig A and G class antibodies to periodontal bacteria were determined at baseline. Read More

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http://dx.doi.org/10.1080/07853890.2020.1724321DOI Listing
February 2020

Endothelial function in patients with atrial fibrillation.

Ann Med 2020 Feb - Mar;52(1-2):1-11. Epub 2020 Jan 10.

Faculty of Health and Life Sciences, Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.

Atrial fibrillation (AF) is the most common heart arrhythmia and is associated with poor outcomes. The adverse effects of AF are mediated through multiple pathways, including endothelial dysfunction, as measured by flow-mediated dilatation. Flow-mediated dilatation has demonstrated endothelial dysfunction in several conditions and is associated with poor outcomes including mortality, yet can be improved with medical therapy. Read More

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http://dx.doi.org/10.1080/07853890.2019.1711158DOI Listing
January 2020

Outcomes of anatomical versus non-anatomical resection for hepatocellular carcinoma according to circulating tumour-cell status.

Ann Med 2020 Feb - Mar;52(1-2):21-31. Epub 2020 Jan 20.

Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.

Hepatic resection is the first-line treatment for hepatocellular carcinoma (HCC). Whether to perform anatomical (AR) or non-anatomical resection (NAR) remains controversial. This retrospective study compares the outcomes according to the number and type of circulating tumour cells (CTCs). Read More

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http://dx.doi.org/10.1080/07853890.2019.1709655DOI Listing
January 2020
3.886 Impact Factor

Treatment of infection.

Ann Med 2020 Feb - Mar;52(1-2):12-20. Epub 2019 Dec 13.

Department of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland.

(formerly: ) infection (CDI) is a major cause of diarrhoea for inpatients as well as outpatients. Usually, CDI is healthcare-associated but the number of community-acquired infections is increasing. CDI is generally associated with changes in the normal intestinal microbiota caused by administration of antibiotics. Read More

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http://dx.doi.org/10.1080/07853890.2019.1701703DOI Listing
December 2019

HDL therapy today: from atherosclerosis, to stent compatibility to heart failure.

Ann Med 2019 Nov - Dec;51(7-8):345-359

Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Epidemiologically, high-density lipoprotein (HDL) cholesterol levels have been inversely associated to cardiovascular (CV) events, although a Mendelian Randomisation Study had failed to establish a clear causal role. Numerous atheroprotective mechanisms have been attributed to HDL, the main being the ability to promote cholesterol efflux from arterial walls; anti-inflammatory effects related to HDL ligands such as S1P (sphingosine-1-phosphate), resolvins and others have been recently identified. Experimental studies and early clinical investigations have indicated the potential of HDL to slow progression or induce regression of atherosclerosis. Read More

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http://dx.doi.org/10.1080/07853890.2019.1694695DOI Listing
July 2020
3.886 Impact Factor

Deep learning-based automatic blood pressure measurement: evaluation of the effect of deep breathing, talking and arm movement.

Ann Med 2019 Nov - Dec;51(7-8):397-403

Research Centre of Intelligent Healthcare, Faculty of Health and Life Science, Coventry University, Coventry, UK.

It is clinically important to evaluate the performance of a newly developed blood pressure (BP) measurement method under different measurement conditions. This study aims to evaluate the performance of using deep learning-based method to measure BPs and BP change under non-resting conditions. Forty healthy subjects were studied. Read More

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http://dx.doi.org/10.1080/07853890.2019.1694170DOI Listing

Impaired albumin function: a novel potential indicator for liver function damage?

Ann Med 2019 Nov - Dec;51(7-8):333-344. Epub 2019 Nov 21.

Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC and Chinese Academy of Medical Sciences, Beijing, China.

Albumin is the most abundant plasma protein and albumin infusion is commonly used. Conventionally, the biologic and therapeutic effects of albumin have been thought to be due to its oncotic properties. However, albumin has a variety of biologic functions, including molecular transport, anti-oxidation, anti-inflammation, endothelial stabilisation, anti-thrombotic effects, and the adjustment of capillary permeability. Read More

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http://dx.doi.org/10.1080/07853890.2019.1693056DOI Listing

The effect of comorbid medical and psychiatric diagnoses on chronic fatigue syndrome.

Ann Med 2019 Nov - Dec;51(7-8):371-378. Epub 2019 Nov 7.

Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

To determine if presence of co-existing medically unexplained syndromes or psychiatric diagnoses affect symptom frequency, severity or activity impairment in Chronic Fatigue Syndrome. Sequential Chronic Fatigue Syndrome patients presenting in one clinical practice. Participants underwent a psychiatric diagnostic interview and were evaluated for fibromyalgia, irritable bowel syndrome and/or multiple chemical sensitivity. Read More

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http://dx.doi.org/10.1080/07853890.2019.1683601DOI Listing
July 2020
3 Reads

Combination of low blood pressure response, low exercise capacity and slow heart rate recovery during an exercise test significantly increases mortality risk.

Ann Med 2019 Nov - Dec;51(7-8):390-396. Epub 2019 Nov 7.

Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, Tampere, Finland.

We investigated the combination of low systolic blood pressure (SBP) response, low exercise capacity (EC) and slow heart rate recovery (HRR) during an exercise test in mortality prediction. Our population consisted of 3456 patients from the Finnish Cardiovascular Study. A failure of SBP to increase >42 mmHg was defined as a low response. Read More

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http://dx.doi.org/10.1080/07853890.2019.1684550DOI Listing
July 2020
1 Read

Thoracic endovascular aortic repair versus open chest surgical repair for patients with type B aortic dissection: a systematic review and meta-analysis.

Ann Med 2019 Nov - Dec;51(7-8):360-370. Epub 2019 Oct 25.

Department of Intensive Care Unit, Suining Central Hospital, Suining, Sichuan, China.

This meta-analysis study aimed to compare the efficacy and safety of TEVAR versus OCSR for TBAD patients. We systematically searched PubMed, EmBase, and the Cochrane library to identify studies compared the effectiveness of TEVAR and OCSR in TBAD patients from the inception up to July 2019. The summary results were calculated using a random-effects model. Read More

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http://dx.doi.org/10.1080/07853890.2019.1679874DOI Listing
July 2020
1 Read

Efficacy and safety of fecal microbiota transplantation for decolonization of intestinal multidrug-resistant microorganism carriage: beyond infection.

Ann Med 2019 Nov - Dec;51(7-8):379-389. Epub 2019 Sep 13.

Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Persistent reservoirs of multidrug-resistant microorganisms (MDRO) that are prevalent in hospital settings and communities can lead to the spread of MDRO. Currently, there are no effective decolonization strategies, especially non-pharmacological strategies without antibiotic regimens. Our aim was to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) for the eradication of MDRO. Read More

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http://dx.doi.org/10.1080/07853890.2019.1662477DOI Listing

Insulin resistance takes center stage: a new paradigm in the progression of bipolar disorder.

Authors:
Cynthia V Calkin

Ann Med 2019 Aug - Sep;51(5-6):281-293. Epub 2019 Aug 27.

Department of Psychiatry, Dalhousie University , Halifax , Canada.

Bipolar Disorder (BD) is a major psychiatric illness affecting up to 5% of the population. BD can progress over time to a chronic "neuroprogressive" course with cognitive and functional impairment. Currently, there are no validated predictors indicating which patients will develop a neuroprogressive course and there are no specific treatments. Read More

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http://dx.doi.org/10.1080/07853890.2019.1659511DOI Listing
August 2019
2 Reads

Response to commentary by Pikus and Harbaugh on: a risk-benefit assessment strategy to exclude cervical artery dissection in spinal manual-therapy: a comprehensive review.

Ann Med 2019 Aug - Sep;51(5-6):332. Epub 2019 Aug 1.

Head and Neck Research Group, Research Centre, Akershus University Hospital , Oslo , Norway.

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http://dx.doi.org/10.1080/07853890.2019.1648853DOI Listing
February 2020

Predictors of high hospital care and medication costs and cost trajectories in community-dwellers with Alzheimer's disease.

Ann Med 2019 Aug - Sep;51(5-6):294-305. Epub 2019 Aug 12.

School of Pharmacy, University of Eastern Finland , Kuopio , Finland.

We studied the determinants of high healthcare costs (highest decile of hospital care and medication costs) and cost trajectories among all community-dwellers with clinically verified Alzheimer's disease (AD), diagnosed during 2005-2011 in Finland ( = 70,531). The analyses were done separately for hospital care costs, medication costs and total healthcare costs that were calculated for each 6-month period from 5 years before to 3 years after AD diagnosis. Total healthcare costs were driven mainly by hospital care costs. Read More

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http://dx.doi.org/10.1080/07853890.2019.1642507DOI Listing

Commentary on: A risk-benefit assessment strategy to exclude cervical artery dissection in spinal manual therapy: a comprehensive review.

Ann Med 2019 Aug - Sep;51(5-6):330-331. Epub 2019 Jul 16.

Penn State Department of Neurosurgery , Hershey , PA , USA.

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http://dx.doi.org/10.1080/07853890.2019.1639807DOI Listing
February 2020

The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD.

Ann Med 2019 Aug - Sep;51(5-6):314-329. Epub 2019 Jul 16.

Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University , Chengdu , China.

C-X-C motif chemokine 5 is primarily chemotactic for neutrophils and previously shown to increase in the bronchoalveolar lavage fluid of patients with chronic obstructive pulmonary disease. However, whether C-X-C motif chemokine 5 levels correlate with lung function decline in patients or mouse model of chronic obstructive pulmonary disease was not clear. The mouse model was induced by cigarette smoke exposure. Read More

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http://dx.doi.org/10.1080/07853890.2019.1639809DOI Listing
July 2019
4 Reads

American heart association's cardiovascular health metrics and risk of cardiovascular disease mortality among a middle-aged male Scandinavian population.

Ann Med 2019 Aug - Sep;51(5-6):306-313. Epub 2019 Jul 12.

Faculty of Sport and Health Sciences, University of Jyvaskyla , Jyvaskyla , Finland.

The burden of cardiovascular disease (CVD) prompted the American Heart Association to develop a cardiovascular health (CVH) metric as a measure to assess the cardiovascular status of the population. We aimed to assess the association between CVH scores and the risk of CVD mortality among a middle-aged Finnish population. We employed the prospective population-based Kuopio Ischemic Heart Disease cohort study comprising of middle-aged men (42-60 years). Read More

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http://dx.doi.org/10.1080/07853890.2019.1639808DOI Listing
July 2019
2 Reads
3.886 Impact Factor

A multidisciplinary consensus on dehydration: definitions, diagnostic methods and clinical implications.

Ann Med 2019 May - Jun;51(3-4):232-251. Epub 2019 Jun 17.

k Centre for Human Health and Performance , University College London , London , UK.

Dehydration appears prevalent, costly and associated with adverse outcomes. We sought to generate consensus on such key issues and elucidate need for further scientific enquiry. A modified Delphi process combined expert opinion and evidence appraisal. Read More

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http://dx.doi.org/10.1080/07853890.2019.1628352DOI Listing
June 2020
10 Reads
3.886 Impact Factor