2,427 results match your criteria Annals of Medicine[Journal]


Microparticles and cardiovascular diseases.

Ann Med 2019 Apr 22:1-71. Epub 2019 Apr 22.

b Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital , Liverpool , United Kingdom.

Microparticles are a distinctive group of small vesicles, without nucleus, which are involved as significant modulators in several physiological and pathophysiological mechanisms. Plasma microparticles from various cellular lines have been subject of research. Data suggest that they are key players in development and manifestation of cardiovascular diseases and their presence, in high levels, is associated with chronic inflammation, endothelial damage and thrombosis. Read More

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http://dx.doi.org/10.1080/07853890.2019.1609076DOI Listing

Identification of novel variants in ten patients with Hermansky-Pudlak syndrome by high-throughput sequencing.

Ann Med 2019 Apr 16:1-8. Epub 2019 Apr 16.

c Department of Hematology and Oncology, University Hospital of Morales Meseguer, Centro Regional de Hemodonación, University of Murcia , Murcia , Spain.

Background: Hermansky-Pudlak syndrome (HPS) is a rare inherited platelet disorder characterized by bleeding diathesis, oculocutaneous albinism (OCA) and a myriad of often-serious clinical complications.

Methods: We established the clinical and laboratory phenotype and genotype of six unrelated pedigrees comprising ten patients with clinical suspicion of HPS; including platelet aggregation, flow cytometry, platelet dense granule content, electron microscopy and high-throughput sequencing (HTS).

Results: The clinical presentation showed significant heterogeneity and no clear phenotype-genotype correlations. Read More

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http://dx.doi.org/10.1080/07853890.2019.1587498DOI Listing
April 2019
1 Read
3.886 Impact Factor

A 30-year follow-up study of patients with Melkersson-Rosenthal syndrome shows an association to inflammatory bowel disease.

Ann Med 2019 Apr 13:1-7. Epub 2019 Apr 13.

a Department of Otorhinolaryngology, Head and Neck Surgery , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.

Background: Melkersson-Rosenthal syndrome (MRS) is often classified under the term orofacial granulomatosis (OFG). A part of OFG patients eventually develop Crohn's disease (CD), but the relationship between MRS and CD is unknown.

Goals: To evaluate the long-term outcomes of MRS patients, with specific interest in bowel-related symptoms. Read More

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http://dx.doi.org/10.1080/07853890.2019.1591634DOI Listing
April 2019
1 Read

The role of exosome in autoimmune connective tissue disease.

Ann Med 2019 Apr 9:1-8. Epub 2019 Apr 9.

a Department of Dermatology , Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , China.

Exosomes have generated significant interest in the last few decades owing to their important roles in a diverse range of biological pathways. They are nano-sized lipid bilayer membrane vesicles of endosomal origin, and are produced by a vast number of cell types. They are released into the extracellular environment and are found in most biological fluids. Read More

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http://dx.doi.org/10.1080/07853890.2019.1592215DOI Listing
April 2019
1 Read
3.886 Impact Factor

Response to commentary by Rhew and colleagues on: Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence.

Ann Med 2019 Feb 1;51(1):99-100. Epub 2019 Apr 1.

c Leicester Diabetes Centre , Leicester General Hospital , Leicester , UK.

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http://dx.doi.org/10.1080/07853890.2019.1581942DOI Listing
February 2019
1 Read
3.886 Impact Factor

A risk-benefit assessment strategy to exclude cervical artery dissection in spinal manual-therapy: a comprehensive review.

Ann Med 2019 Mar 19:1-10. Epub 2019 Mar 19.

a Head and Neck Research Group, Research Centre, Akershus University Hospital , Oslo , Norway.

Cervical artery dissection refers to a tear in the internal carotid or the vertebral artery that results in an intramural haematoma and/or an aneurysmal dilatation. Although cervical artery dissection is thought to occur spontaneously, physical trauma to the neck, especially hyperextension and rotation, has been reported as a trigger. Headache and/or neck pain is the most common initial symptom of cervical artery dissection. Read More

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http://dx.doi.org/10.1080/07853890.2019.1590627DOI Listing
March 2019
2 Reads

Commentary on: Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence.

Ann Med 2019 Feb 1;51(1):97-98. Epub 2019 Apr 1.

a Department of Pharmaceutical Outcomes and Policy, College of Pharmacy , University of Florida , Gainesville , FL , USA.

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http://dx.doi.org/10.1080/07853890.2019.1581941DOI Listing
February 2019

Coeliac disease: beyond genetic susceptibility and gluten. A narrative review.

Ann Med 2019 Feb 11;51(1):1-16. Epub 2019 Mar 11.

a Department of Medical , Surgical and Experimental Sciences, University of Sassari , Sassari , Italy.

Coeliac disease (CD) is an immune-mediated disorder triggered by the ingestion of gluten in genetically susceptible individuals. However, only a small proportion of subjects harbouring CD-related genetic risk develop the disease. Among the environmental factors that may influence CD risk, pre- and perinatal factors, delivery methods, parental lifestyle, infant feeding practices, seasonality, dietary factors, drug use, childhood infections and variability in gut microbiota are those most widely studied regarding the risk to develop CD. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2019.1
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http://dx.doi.org/10.1080/07853890.2019.1569254DOI Listing
February 2019
6 Reads

Cardiovascular health in urban Chinese children and adolescents.

Ann Med 2019 Feb 12;51(1):88-96. Epub 2019 Mar 12.

a Beijing Children's Hospital, Capital Medical University, National Center for Children's Health , Beijing , China.

Introduction: Cardiovascular diseases remain the leading cause of death and disease burden in China and worldwide. We aimed to evaluate the status of cardiovascular health among urban Chinese children and adolescents.

Methods: We conducted a cross-sectional study comprising 12,618 children and adolescents aged 6-18 years, who were recruited from Chinese urban areas during 2013-2015. Read More

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http://dx.doi.org/10.1080/07853890.2019.1580383DOI Listing
February 2019

Dietary interventions in Fibromyalgia: a systematic review.

Ann Med 2019 Feb 8:1-29. Epub 2019 Feb 8.

a Faculdade de Ciências da Nutrição e Alimentação , Universidade do Porto , Rua Dr. Roberto Frias , 4200-465 Porto , Portugal.

Fibromyalgia (FM) is a chronic non-degenerative disease, whose nutritional therapy seems controversial. This systematic review aimed to synthesize the knowledge about the effect of dietary interventions on patient reported outcomes (PRO) and inflammation in patients with FM. Six electronic databases - PubMed, BioMed Central, Cochrane library, EMBASE, LILACS and ISI - were searched for clinical trials, in which a dietary intervention in patients with FM diagnosed was conducted. Read More

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http://dx.doi.org/10.1080/07853890.2018.1564360DOI Listing
February 2019
18 Reads

Effects of occlusal splints on shoulder strength and activation.

Ann Med 2019 Jan 10:1-22. Epub 2019 Jan 10.

a Laboratory of Motor Behavior , CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa , Portugal.

Introduction: The use of oral appliances to enhance sports performance has been advocated by some authors, however, studies addressing the effectiveness of these strategies are inconclusive.

Methods: Here we investigate the effects of dental occlusions on shoulder strength. Fourteen healthy male subjects (age =21. Read More

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http://dx.doi.org/10.1080/07853890.2019.1566766DOI Listing
January 2019
1 Read

Chronic diseases and objectively monitored physical activity profile among aged individuals - a cross-sectional twin cohort study.

Ann Med 2019 Feb 5;51(1):78-87. Epub 2019 Mar 5.

b The UKK Institute for Health Promotion Research , Tampere , Finland.

Introduction: High physical activity (PA) at old age indicates good functional capacity enabling independent living. We investigated how different disease conditions are associated with measured PA indicators in old women and men, and whether they recognize this association.

Materials And Methods: This cross-sectional twin cohort study in Finland comprised 779 individuals (276 complete twin pairs, including 117 monozygotic pairs), who participated in hip-worn accelerometer monitoring of PA and responded to questions on diseases and mobility limitations at mean age of 73 (range 71-75). Read More

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http://dx.doi.org/10.1080/07853890.2019.1566765DOI Listing
February 2019
1 Read

Use of antihypertensive medication after ischemic stroke in young adults and its association with long-term outcome.

Ann Med 2019 Feb 14;51(1):68-77. Epub 2019 Feb 14.

b Department of Neurology, Clinical Neurosciences , University of Helsinki , Helsinki , Finland.

Background: Knowledge on the use of secondary preventive medication in young adults is limited.

Methods: We included 936 first-ever ischemic stroke 30-day survivors aged 15-49, enrolled in the Helsinki Young Stroke Registry, 1994-2007. Follow-up data until 2012 came from Finnish Care Register, Statistics Finland, and Social Insurance Institution of Finland. Read More

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http://dx.doi.org/10.1080/07853890.2018.1564358DOI Listing
February 2019
4 Reads

Prognostic significance of CDKN2A/B deletions in acute lymphoblastic leukaemia: a meta-analysis.

Ann Med 2019 Feb 14;51(1):28-40. Epub 2019 Feb 14.

a Department of Haematology , West China Hospital, Sichuan University , Chengdu , P.R. China.

Background: Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) genes are frequently altered in acute lymphoblastic leukaemia (ALL) patients. The aim of this meta-analysis was to comprehensively assess the prognostic value of CDKN2A/B deletions in ALL patients.

Methods: Systematic literature review was conducted in PubMed, Embase and Cochrane databases up to July 2018. Read More

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http://dx.doi.org/10.1080/07853890.2018.1564359DOI Listing
February 2019
1 Read

The associations of daylight and melatonin receptor 1B gene rs10830963 variant with glycemic traits: the prospective PPP-Botnia study.

Ann Med 2019 Feb 14;51(1):58-67. Epub 2019 Feb 14.

a Department of Psychology and Logopedics , University of Helsinki , Helsinki , Finland.

Background: Seasonal variation in glucose metabolism might be driven by changes in daylight. Melatonin entrains circadian regulation and is directly associated with daylight. The relationship between melatonin receptor 1B gene variants with glycemic traits and type 2 diabetes is well established. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1564357DOI Listing
February 2019
6 Reads

Editorial.

Ann Med 2018 Dec 24. Epub 2018 Dec 24.

a Egas Moniz - Cooperativa de Ensino Superior CRL, Centro de Investigação Interdisciplinar Egas Moniz , Monte de Caparica , Portugal.

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http://dx.doi.org/10.1080/07853890.2018.1563378DOI Listing
December 2018
1 Read

Correction.

Authors:

Ann Med 2018 Nov 21;50(7):634-635. Epub 2018 Nov 21.

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http://dx.doi.org/10.1080/07853890.2018.1519954DOI Listing
November 2018
2 Reads

Dietary sodium intake is associated with long-term risk of new-onset atrial fibrillation.

Ann Med 2018 Dec 23;50(8):694-703. Epub 2018 Nov 23.

a Medical Research Center Oulu , Oulu University Hospital and University of Oulu , Oulu , Finland.

Background: The association between dietary salt intake and hypertension has been well documented. We evaluated the association between dietary sodium intake and the incidence of new-onset atrial fibrillation (AF) during a mean follow-up of 19 years among 716 subjects from the Oulu Project Elucidating Risk of Atherosclerosis (OPERA) cohort.

Material And Methods: Dietary sodium intake was evaluated from a seven-day food record. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1546054DOI Listing
December 2018
14 Reads

Efficacy and safety of intravenous esmolol for cardiac protection in non-cardiac surgery. A systematic review and meta-analysis.

Ann Med 2019 Feb 26;51(1):17-27. Epub 2018 Nov 26.

a Department of Perioperative, Intensive Care and Pain Medicine , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Haemodynamic instability predisposes patients to cardiac complications in non-cardiac surgery. Esmolol, a short-acting cardioselective beta-adrenergic blocker might be efficient in perioperative cardiac protection, but could affect other vital organs, such as the kidneys, and post-discharge survival. We performed a systematic review on the use of esmolol for perioperative cardiac protection. Read More

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http://dx.doi.org/10.1080/07853890.2018.1538565DOI Listing
February 2019
10 Reads

Update on extended treatment for venous thromboembolism.

Ann Med 2018 Dec 29;50(8):666-674. Epub 2018 Dec 29.

a Venous Thromboembolism Unit, Internal Medicine Department , Hospital General Universitario Gregorio Marañón , Madrid , Spain.

The importance of assessing the probability of venous thromboembolism recurrence, a condition that includes deep vein thrombosis and pulmonary embolism, lies in the fact that it is the most important factor in deciding the duration of anticoagulant treatment. Risk of recurrence depends mostly on the presence of a risk factor for developing venous thromboembolism, with patients with unprovoked events being at the higher risk of recurrence. The risk of recurrence needs to be balanced with the risk of bleeding and the potential severity of these thrombotic and hemorrhagic events. Read More

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http://dx.doi.org/10.1080/07853890.2018.1538564DOI Listing
December 2018
20 Reads

The association between exposure to second-hand smoke and major depressive disorder in perimenopausal women: results from apopulation-based study.

Ann Med 2018 Nov 19;50(7):596-604. Epub 2018 Nov 19.

b School of Medicine , Chang Gung University , Taoyuan , Taiwan.

Purpose: The aim of this study was to test the hypothesis that exposure to second-hand smoke (SHS) would be positively associated with major depressive disorder (MDD) in perimenopausal women from a population-based perspective, after adjustment for all potential confounders.

Methods: This study used the National Health and Nutrition Examination Survey (NHANES) database, 2005-2012, to report on MDD in perimenopausal women.

Results: The odds ratio (OR) for MDD increased when there was a smoker was in the home, as compared to not having a smoker in the home (aOR = 2. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1534264DOI Listing
November 2018
3 Reads

Risk of preterm birth in primiparous women with exposure to antidepressant medication before pregnancy and/or during pregnancy - impact of body mass index.

Ann Med 2019 Feb 19;51(1):51-57. Epub 2018 Nov 19.

a Department of General Practice and Primary Health Care , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Introduction: Preterm birth is a major cause of infant mortality. It is unknown whether body mass index (BMI) influences the risk of preterm birth in women, who prenatally use antidepressants.

Materials And Methods: The study cohort (N = 6920) consists of all primiparous European born women without previously diagnosed diabetes from the city of Vantaa, Finland, who delivered a singleton child between 2009 and 2015. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1534265DOI Listing
February 2019
5 Reads
3.890 Impact Factor

Corrigendum.

Authors:

Ann Med 2018 Nov 29;50(7):636. Epub 2018 Sep 29.

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1492693DOI Listing
November 2018
3 Reads

The validation of smartphone applications for heart rate measurement.

Ann Med 2018 Dec 17;50(8):721-727. Epub 2018 Nov 17.

a Department of Medicine , Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok , Thailand.

Background: The smartphone apps provide a user-friendly option for measurement of heart rate (HR) by detecting pulsatile photoplethysmographic signals with built-in cameras from the fingertips, however, the validation study is limited.

Methods: We compared HR detected by the smartphone apps (App1 = Instant HR, App2 = Cardiio: HR Monitor and App3 = Runtastic HR Monitor) with simultaneous standard ECG monitoring in the adult patients at the critical care unit.

Results: HR measurements were obtained from 140 patients with mean age 67. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1531144DOI Listing
December 2018
6 Reads

Prospects for circadian treatment of mood disorders.

Ann Med 2018 Dec 10;50(8):637-654. Epub 2018 Nov 10.

a Circadian Biology Group, Department of Psychiatry , Ludwig Maximilian University , Munich , Germany.

Disruption of circadian clocks is strongly associated with mood disorders. Chronotherapies targeting circadian rhythms have been shown to be very effective treatments of mood disorders, but still are not widely used in clinical practice. The mechanisms by which circadian disruption leads to mood disorders are poorly characterized and, therefore, may not convince clinicians to apply chronotherapies. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1530449DOI Listing
December 2018
27 Reads

Cardiac Troponin - diagnostic problems and impact on cardiovascular disease.

Ann Med 2018 Dec 21;50(8):655-665. Epub 2018 Nov 21.

a King's College London BHF Centre , The Rayne Institute, St Thomas' Hospital , London , UK.

The definition of a high-sensitivity cardiac Troponin (cTn) assay describes the ability to quantify a cardiac biomarker level in at least 50% of healthy individuals. This advance in analytic sensitivity has come with a perceived loss of specificity in the most classic application - chest pain triage and the diagnosis of acute myocardial infarction (AMI). As cardiac Troponin can no longer be used as a dichotomous test, the medical field is increasingly moving towards a more granular interpretation. Read More

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http://dx.doi.org/10.1080/07853890.2018.1530450DOI Listing
December 2018
23 Reads

Prevalence, incidence and mortality of inflammatory bowel disease in Catalonia. A population-based analysis.

Ann Med 2018 Nov 19;50(7):613-619. Epub 2018 Nov 19.

a Servei Aparell Digestiu, Hospital Universitari Parc Taulí , Sabadell , Spain.

Introduction: Few recent data on the epidemiology of inflammatory bowel disease (IBD) are available, especially in Southern Europe.

Aim: To evaluate the prevalence, incidence and mortality of IBD in Catalonia during the period 2011-2016.

Material And Methods: Data on the prevalence, incidence and mortality of IBD were obtained from the Catalan Health Surveillance System (CHSS). Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1523550DOI Listing
November 2018
20 Reads

Invasive pulmonary aspergillosis in patients with solid tumours: risk factors and predictors of clinical outcomes.

Ann Med 2018 Dec 29;50(8):713-720. Epub 2018 Sep 29.

b Department of Infectious Diseases, Infection Control & Employee Health , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.

Background: The characteristics and management of invasive pulmonary aspergillosis (IPA) in patients with hematologic malignancies are well known, but IPA in patients with solid tumours is not well described.

Methods: We retrospectively reviewed all Aspergillus-positive cultures at a tertiary cancer center during 2004-2017. We identified 101 patients with IPA and solid tumours. Read More

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http://dx.doi.org/10.1080/07853890.2018.1518581DOI Listing
December 2018
15 Reads

Age at death in cohorts of middle-aged men followed-up until nearly extinction: the European areas of the Seven Countries Study.

Ann Med 2018 Nov 25;50(7):620-633. Epub 2018 Oct 25.

e Department of Social Medicine, Preventive Medicine and Nutrition Clinic , University of Crete , Heraklion , Greece.

Objectives: To describe age at death (AD) in ten cohorts of middle-aged men followed-up until nearly extinction as a function of personal characteristics measured at baseline.

Material And Methods: Cohorts of men aged 40-59 years in five European countries (Finland, the Netherlands, Italy, Serbia, Greece) were examined and then followed-up for mortality during 45 (3 cohorts) or 50 years (7 cohorts). Multiple linear regression (MLR) models were computed with AD as dependent variable and 35 personal characteristics as independent variables. Read More

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http://dx.doi.org/10.1080/07853890.2018.1523551DOI Listing
November 2018
6 Reads

Cardioversion for atrial fibrillation - how to prevent thromboembolic complications?

Ann Med 2018 Nov 15;50(7):549-555. Epub 2018 Oct 15.

a Heart Center , Turku University Hospital and University of Turku , Turku , Finland.

Cardioversion is an essential component of rhythm control strategy for atrial fibrillation. The thromboembolic risk of cardioversion is well established and the mechanisms behind the phenomenon have been comprehensively described. There are several clinical aspects that are important to take into consideration when assessing the safety of cardioversion. Read More

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http://dx.doi.org/10.1080/07853890.2018.1523552DOI Listing
November 2018
3 Reads

Triglyceride glucose and haemoglobin glycation index for predicting outcomes in diabetes patients with new-onset, stable coronary artery disease: a nested case-control study.

Ann Med 2018 Nov 25;50(7):576-586. Epub 2018 Oct 25.

a Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease , Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , China.

Aim: Previous studies have shown that both triglyceride glucose (TyG) and haemoglobin glycation indexes (HGI) are predictors of cardiovascular risk. However, the prognostic value of TyG index and HGI in patients with type 2 diabetes mellitus (T2DM) and stable coronary artery disease (CAD) is not determined.

Methods: We conducted a nested case-control study among 1282 T2DM patients with stable CAD. Read More

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http://dx.doi.org/10.1080/07853890.2018.1523549DOI Listing
November 2018
4 Reads

Hospitalization rate of paroxysmal supraventricular tachycardia in Sweden.

Ann Med 2018 Nov 15;50(7):556-564. Epub 2018 Oct 15.

a Center for Primary Health Care Research, Lund University/Region Skåne , Malmö , Sweden.

Introduction: The hospitalization rate of paroxysmal supraventricular tachycardia (PSVT) in a nationwide study is not established. We determined age- and sex-specific hospitalization rates and time trends for hospitalized PSVT in the Swedish population between 1987 and 2010.

Methods: This nationwide study is based on the Swedish Hospital Discharge Register. Read More

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http://dx.doi.org/10.1080/07853890.2018.1521525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441476PMC
November 2018
7 Reads

Implications of low muscle mass across the continuum of care: a narrative review.

Ann Med 2018 Dec 12;50(8):675-693. Epub 2018 Sep 12.

g Pennington Biomedical Research Center , Baton Rouge , LA , USA.

Abnormalities in body composition can occur at any body weight. Low muscle mass is a predictor of poor morbidity and mortality and occurs in several populations. This narrative review provides an overview of the importance of low muscle mass on health outcomes for patients in inpatient, outpatient and long-term care clinical settings. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1511918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370503PMC
December 2018
29 Reads

A new prediction model for assessing the clinical outcomes of ICU patients with community-acquired pneumonia: a decision tree analysis.

Ann Med 2019 Feb 23;51(1):41-50. Epub 2019 Mar 23.

b Department of Critical Care Medicine, Second Affiliated Hospital , Zhejiang University School of Medicine , Hangzhou , Zhejiang , PR China.

Purpose: We aimed to develop a new scoring index based on decision-tree analysis to predict clinical outcomes of patients with community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU).

Methods: Data of 3519 ICU patients with CAP were obtained from the Medical Information Mart for Intensive Care III (MIMIC III) 2001-2012 database and analysed between 30-d survivors and non-survivors. Accuracy, sensitivity, and specificity of the new decision tree model were compared with those of CURB-65 and SOAR. Read More

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http://dx.doi.org/10.1080/07853890.2018.1518580DOI Listing
February 2019
4 Reads

Response to "Why all randomized controlled trials produce biased results".

Ann Med 2018 Nov 12;50(7):545-548. Epub 2018 Sep 12.

d Department of Biostatistics , Vanderbilt University , Nashville , TN , USA.

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http://dx.doi.org/10.1080/07853890.2018.1514529DOI Listing
November 2018
2 Reads

Approaches to rapid acting insulin intensification in patients with type 2 diabetes mellitus not achieving glycemic targets.

Ann Med 2018 Sep 25;50(6):453-460. Epub 2018 Aug 25.

d Lilly Corporate Center , Eli Lilly & Company , Indianapolis , IN , USA.

Type 2 diabetes mellitus (T2DM) is a growing problem in the USA, affecting 30.3 million Americans, or 9.4% of the US population. Read More

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http://dx.doi.org/10.1080/07853890.2018.1493216DOI Listing
September 2018
21 Reads

Effect of omega-3 supplements on plasma apolipoprotein C-III concentrations: a systematic review and meta-analysis of randomized controlled trials.

Ann Med 2018 Nov 29;50(7):565-575. Epub 2018 Sep 29.

h Department of Internal medicine, School of Medicine , University Hospital Center Zagreb, University of Zagreb , Zagreb , Croatia.

Background: Apolipoprotein C-III (apo C-III) is a key regulator of triglycerides metabolism. The aim of this meta-analysis was to assess the effect of fish omega-3 polyunsaturated fatty acids (PUFAs) on apo C-III levels.

Methods: Randomized placebo-controlled trials investigating the impact of omega-3 on apo C-III levels were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar. Read More

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http://dx.doi.org/10.1080/07853890.2018.1511919DOI Listing
November 2018
12 Reads

Increased risk for major depressive disorder in severely obese patients after bariatric surgery - a 12-year nationwide cohort study.

Ann Med 2018 Nov 7;50(7):605-612. Epub 2018 Sep 7.

a Department of Family Medicine , National Taiwan University Hospital , Taipei , Taiwan.

Background: Bariatric surgery is associated with a significant improvement in depressive mood in the initial postoperative years, but the maintenance of the improvement is under debate.

Aim: To explore the association between bariatric surgery and major depressive disorder (MDD) in a 12-year nationwide cohort study.

Method: Using the National Health Insurance Research Database of Taiwan, we identified 2302 patients who underwent bariatric surgery in 2001-2009. Read More

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http://dx.doi.org/10.1080/07853890.2018.1511917DOI Listing
November 2018
3 Reads

Melatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits.

Ann Med 2018 Dec 12;50(8):704-712. Epub 2018 Sep 12.

a Department of Psychology and Logopedics , University of Helsinki , Helsinki , Finland.

Background: The association between depression and type 2 diabetes is bidirectional. Underlying biological determinants remain elusive. We examined whether a common melatonin receptor 1B gene diabetes risk variant rs10830963 influenced the associations between depressive symptoms and glycaemic traits. Read More

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http://dx.doi.org/10.1080/07853890.2018.1509118DOI Listing
December 2018
33 Reads

Relationship between the FRAX index and physical and cognitive functioning in older people.

Ann Med 2018 Sep 7;50(6):538-543. Epub 2018 Sep 7.

b Internal Medicine Department , Hospital Universitario Río Hortega , Valladolid , Spain.

Objective: To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people.

Patients And Methods: Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1505052DOI Listing
September 2018
10 Reads

Morphology and histology of silent and symptom-causing atherosclerotic carotid plaques - Rationale and design of the Helsinki Carotid Endarterectomy Study 2 (the HeCES2).

Ann Med 2018 Sep 1;50(6):501-510. Epub 2018 Oct 1.

a Molecular Neurology, Research Programs Unit, Biomedicum Helsinki , University of Helsinki , Helsinki , Finland.

Introduction: Every fifth ischemic stroke is caused by thromboembolism originating from an atherosclerotic carotid artery plaque. While prevention is the most cost-effective stroke therapy, antiplatelet and cholesterol-lowering drugs have a ceiling effect in their efficacy. Therefore, discovery of novel pathophysiologic targets are needed to improve the primary and secondary prevention of stroke. Read More

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http://dx.doi.org/10.1080/07853890.2018.1494851DOI Listing
September 2018
7 Reads

Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence.

Ann Med 2018 Sep 25;50(6):529-537. Epub 2018 Aug 25.

c Leicester Diabetes Centre, Leicester General Hospital , Leicester , UK.

Purpose: Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk.

Design: Eligible studies were identified in a literature search of MEDLINE, Embase, Web of Science and reference list of relevant studies up to April 2018. Read More

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http://dx.doi.org/10.1080/07853890.2018.1500703DOI Listing
September 2018
7 Reads
3.890 Impact Factor

Estimate of ischemic stroke prevalence according to a novel 4-tiered classification of left ventricular hypertrophy: insights from the general Chinese population.

Ann Med 2018 Sep 1;50(6):519-528. Epub 2018 Dec 1.

a Department of Cardiology , The First Hospital of China Medical University , Shenyang , Liaoning , China.

Background: Recently, a novel 4-tiered classification of left ventricular hypertrophy (LVH) based on ventricular dilatation (indexed LV end-diastolic volume [EDV]) and concentricity (mass/EDV) has improved all-cause and cardiovascular mortality risk stratification. However, their possible association with ischemic stroke has not been extensively evaluated in the general population.

Methods: We evaluated a cross-sectional study of 11,037 subjects from the general population of China in whom echocardiographic and ischemic stroke data were available to subdivide patients with LVH into four geometric patterns: indeterminate, dilated, thick and both thick and dilated hypertrophy. Read More

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http://dx.doi.org/10.1080/07853890.2018.1500702DOI Listing
September 2018
10 Reads

Lipid lowering drugs and inflammatory changes: an impact on cardiovascular outcomes?

Ann Med 2018 Sep 15;50(6):461-484. Epub 2018 Oct 15.

c Centro Dislipidemie , A.S.S.T. Grande Ospedale Metropolitano Niguarda , Milan , Italy.

Inflammatory changes are responsible for maintenance of the atherosclerotic process and may underlie some of the most feared vascular complications. Among the multiple mechanisms of inflammation, the arterial deposition of lipids and particularly of cholesterol crystals is the one responsible for the activation of inflammasome NLRP3, followed by the rise of circulating markers, mainly C-reactive protein (CRP). Elevation of lipoproteins, LDL but also VLDL and remnants, associates with increased inflammatory changes and coronary risk. Read More

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http://dx.doi.org/10.1080/07853890.2018.1498118DOI Listing
September 2018
5 Reads

Impact of fibrates on circulating cystatin C levels: a systematic review and meta-analysis of clinical trials.

Ann Med 2018 Sep 7;50(6):485-493. Epub 2018 Sep 7.

m Anti-Doping Laboratory Qatar , Life Sciences & Research Division , Doha , Qatar.

Aims: To assess the effect of fibrates on circulating cystatin C levels.

Material And Methods: Clinical studies evaluating the effect of a fibrate on circulating cystatin C levels were searched in PubMed-Medline, SCOPUS, Web of Science, and Google Scholar databases. A random-effect model and generic inverse variance method were used for quantitative data synthesis, sensitivity analysis conducted using the leave-one-out method, and weighted random-effects meta-regression performed to evaluate potential confounders on cystatin C levels. Read More

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http://dx.doi.org/10.1080/07853890.2018.1495338DOI Listing
September 2018
55 Reads

Left atrial thrombus resolution in non-valvular atrial fibrillation or flutter: biomarker substudy results from a prospective study with rivaroxaban (X-TRA).

Ann Med 2018 Sep;50(6):511-518

i Department of Cardiology , Hospital Clínico Universitario Virgen de la Arrixaca, IMIB-Arrixaca, CIBER-CV , Murcia , Spain.

Background: Non-vitamin K antagonist oral anticoagulants including rivaroxaban are widely used for stroke prevention in patients with atrial fibrillation (AF). We investigated the relationship between plasma biomarkers (indicative of thrombogenesis, fibrinolysis and inflammation) and left atrial thrombus resolution after rivaroxaban treatment.

Methods: This was an ancillary analysis of the X-TRA study, which was a prospective interventional study evaluating the use of rivaroxaban for left atrial/left atrial appendage (LA/LAA) thrombus resolution in AF patients. Read More

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http://dx.doi.org/10.1080/07853890.2018.1495337DOI Listing
September 2018
22 Reads

A practical approach to infarction of the spleen as a rare manifestation of multiple common diseases.

Ann Med 2018 Sep 31;50(6):494-500. Epub 2018 Jul 31.

a Department of Internal Medicine B , Meir Medical Center , Kfar Saba , Israel.

Introduction: There are insufficient data on the aetiologic factors underlying splenic infarction (SI). Therefore, there is no consensus regarding the appropriate diagnostic approach.

Methods: We conducted a retrospective analysis of all patients admitted with SI from January 2004 to December 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/07853890.2018.1
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http://dx.doi.org/10.1080/07853890.2018.1492148DOI Listing
September 2018
17 Reads

The association of non-alcoholic fatty liver disease and atrial fibrillation: a review.

Ann Med 2018 Aug 24;50(5):371-380. Epub 2018 Jul 24.

b Research Unit of Internal Medicine, Medical Research Center Oulu , Oulu University Hospital, and University of Oulu , Oulu , Finland.

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes an enormous burden to human health and health-care systems all over the world. A great proportion of this burden results from increased risk of cardiovascular diseases. Atrial fibrillation (AF) is the most common chronic heart arrhythmia globally and it increases the risk of embolic stroke and heart failure. Read More

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http://dx.doi.org/10.1080/07853890.2018.1492147DOI Listing
August 2018
4 Reads

Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study.

Ann Med 2018 Aug 21;50(5):443-452. Epub 2018 Jul 21.

b Research Institute for Human Health Information , Ewha Womans University Mokdong Hospital , Seoul , Korea.

Background: The effects of each blood pressure index [systolic and diastolic blood pressure (SBP, DBP), pulse pressure (PP), mean arterial pressure (MAP)] on the occurrence of mortality and cardiovascular (CV) events have not yet been investigated in prehypertensive populations.

Methods: A total of 30,258 prehypertensive Korean participants underwent periodic health examination between 2003 and 2004 were enrolled, and the associations of BP components with mortality and CV events were investigated. Moreover, based on the DBP [80 ≤ DBP <90 mmHg (N = 21,323) and DBP <80 mmHg (N = 8,935)], the effects of BP components were also evaluated. Read More

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http://dx.doi.org/10.1080/07853890.2018.1492146DOI Listing
August 2018
4 Reads

Inflammatory bowel disease: new therapies from antisense oligonucleotides.

Ann Med 2018 Aug 21;50(5):361-370. Epub 2018 Jul 21.

a Department of Systems Medicine , University of Rome Tor Vergata , Rome, Italy.

Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal manifestations. The cause of IBD remains unknown but accumulating evidence indicates that both CD and UC arise in genetically predisposed individuals as a result of the action of multiple environmental factors, which ultimately trigger excessive and poorly controlled immune response against antigens of the luminal flora. Read More

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http://dx.doi.org/10.1080/07853890.2018.1490025DOI Listing
August 2018
5 Reads