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Ann Lab Med 2022 09;42(5):612-615

Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Ann Lab Med 2022 09;42(5):609-611

Department of Laboratories Medicine, West China Hospital, Sichuan University, Chengdu, China.

Ann Lab Med 2022 09;42(5):606-608

UOC Medicina di Laboratorio Azienda Usl Nord Ovest, Pontedera, Italy.

Ann Lab Med 2022 09;42(5):602-605

Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea.

Ann Lab Med 2022 Sep;42(5):597-601

Flinders University International Centre for Point-of-Care Testing, Flinders Health and Medical Research Institute, Flinders University, Adelaide, Australia.

This study describes an objective approach to deriving the clinical performance of autoverification rules to inform laboratory practice when implementing them. Anonymized historical laboratory data for 12 biochemistry measurands were collected and Box-Cox-transformed to approximate a Gaussian distribution. The historical laboratory data were assumed to be error-free. Read More

Ann Lab Med 2022 09;42(5):590-596

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

The translocation (3;21)(q26.2;q22.1) is a unique cytogenetic aberration that characterizes acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) in patients with AML and myelodysplastic syndrome (MDS) or a therapy-related myeloid neoplasm. Read More

Ann Lab Med 2022 Sep;42(5):585-589

BioMedical Sciences Graduate Program (BMSGP), Chonnam National University and Chonnam National University Hwasun Hospital, Hwasun, Korea.

Cytogenetically normal acute myeloid leukemia (CN-AML) accounts for 40%-50% of all AML cases. Despite advances in understanding the molecular pathophysiology of CN-AML, its clinical outcome remains unsatisfactory and unpredictable. To investigate its clinical implication in CN-AML, we measured the expression of prohibitin 2 (PHB2) using immunohistochemical staining (IHCS) of paraffin-embedded bone marrow sections from 134 CN-AML patients. Read More

Ann Lab Med 2022 Sep;42(5):575-584

National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Background: To identify candidate external quality assessment (EQA) materials for normetanephrine and metanephrine measurements, we assessed the commutability of eight processed human plasma samples. The agreement between routine assays and the candidate reference measurement procedure (cRMP) was also evaluated.

Methods: Fifty-three clinical samples and eight processed plasma samples were prepared. Read More

Ann Lab Med 2022 Sep;42(5):566-574

Department of Laboratory Medicine, AZ Groeninge Hospital, Kortrijk, Belgium.

Background: Chloride measurement is crucial for calculating the anion gap. Bicarbonate can interfere with chloride measurements; however, there is no information on the specific types of electrodes affected or the changes in bicarbonate non-selectivity over time. We evaluated the interference of bicarbonate on chloride measurements using different electrodes and the stability of this interference over time. Read More

Ann Lab Med 2022 Sep;42(5):558-565

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Minimal residual disease (MRD) is an important prognostic factor for evaluating a deeper treatment response in patients with multiple myeloma (MM). We evaluated the clinical utility of next-generation flow (NGF)-based MRD assessment in a heterogeneous MM patient population.

Methods: Patients with suspected morphological remission after or during MM treatment were prospectively enrolled. Read More

Ann Lab Med 2022 Sep;42(5):531-557

Laboratory Corporation of America Holdings, Research Triangle Park, NC, USA.

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is increasingly utilized in clinical laboratories because it has advantages in terms of specificity and sensitivity over other analytical technologies. These advantages come with additional responsibilities and challenges given that many assays and platforms are not provided to laboratories as a single kit or device. The skills, staff, and assays used in LC-MS/MS are internally developed by the laboratory, with relatively few exceptions. Read More

Ann Lab Med 2022 Sep;42(5):515-530

Division of Hematopathology, Department of Pathology, Anatomy, and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Automated hematology analyzers generate accurate complete blood counts (CBC) results on nearly all specimens. However, every laboratory encounters, at times, some specimens that yield no or inaccurate result(s) for one or more CBC parameters even when the analyzer is functioning properly and the manufacturer's instructions are followed to the letter. Inaccurate results, which may adversely affect patient care, are clinically unreliable and require the attention of laboratory professionals. Read More

Ann Lab Med 2022 Sep;42(5):507-514

Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

With the rapid spread of the coronavirus disease (COVID-19), the need for rapid testing and diagnosis and consequently, the demand for mobile laboratories have increased. Despite this need, there are no clear guidelines for the operation, maintenance, or quality control of mobile laboratories. We provide guidelines for the operation, management, and quality control of mobile laboratories, and specifically for the implementation and execution of COVID-19 molecular diagnostic testing. Read More

Ann Lab Med 2022 09;42(5):505-506

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

Ann Lab Med 2022 Jul;42(4):500-503

Department of Pediatrics, Jeonbuk National University Medical School, Jeonju, Korea.

Ann Lab Med 2022 Jul;42(4):497-499

Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu, Korea.

Ann Lab Med 2022 Jul;42(4):494-496

Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.

Ann Lab Med 2022 Jul;42(4):491-493

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Ann Lab Med 2022 Jul;42(4):488-490

Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, Korea.

Ann Lab Med 2022 Jul;42(4):485-487

Department of Laboratory Medicine, Kyung Hee University Hospital, Seoul, Korea.

Ann Lab Med 2022 Jul;42(4):482-484

Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea.

Ann Lab Med 2022 Jul;42(4):478-481

Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea.

Group B streptococcus (GBS) is an important pathogen causing neonatal early-onset disease. We evaluated the diagnostic performance of BD Max GBS assay (Becton Dickinson, Franklin Lakes, NJ, USA) without enrichment (direct BDM) for detecting GBS using vaginal and rectal specimens in comparison with culture. In total, 716 specimens collected from 358 pregnant women between June 2018 and May 2020 were included in this study. Read More

Ann Lab Med 2022 Jul;42(4):473-477

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza viruses may pose enormous challenges to our healthcare system. We evaluated the performance of the PowerChek SARS-CoV-2, Influenza A & B Multiplex Real-time PCR Kit (PowerChek; Kogene Biotech, Seoul, Korea) in comparison with the BioFire Respiratory Panels 2 and 2.1 (RP2 and RP2. Read More

Ann Lab Med 2022 Jul;42(4):467-472

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Blood gas, electrolyte, glucose, and lactate level measurement have an immediate and critical impact on patient care. We evaluated the performance of i-SmartCare 10 (i-SENS Inc., Seoul, Korea) and conducted a method comparison study of five point-of-care (POC) analyzers with i-SmartCare 10 as the comparator, according to the CLSI guidelines. Read More

Ann Lab Med 2022 Jul;42(4):457-466

Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

Background: Reagent red blood cells (RBCs) are prepared from donated whole blood, resulting in various combinations of blood group antigens. This inconsistency can be resolved by producing RBCs with uniform antigen expression. Induced pluripotent stem cells (iPSCs) generated directly from mature cells constitute an unlimited source for RBC production. Read More

Ann Lab Med 2022 Jul;42(4):447-456

Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Accurate and consistent viral load (VL) quantitation of HIV type 1 (HIV-1), hepatitis B virus (HBV), and hepatitis C virus (HCV) is important for diagnosis and clinical monitoring. Assay results have to be concordant and compatible across laboratories. We evaluated the performance of three Aptima assays (Hologic, San Diego, CA, USA) and compared their VL values with corresponding cobas 6800 assay (Roche Diagnostics, Mannheim, Germany) results, using 840 clinical samples. Read More

Ann Lab Med 2022 Jul;42(4):438-446

Department of Laboratory Medicine, Gyeongsang National University Changwon Hospital, Changwon, Korea.

Background: Few studies have investigated the invasiveness of based on whole-genome sequencing (WGS). Using WGS, we determined the genomic features associated with invasiveness of strains in Korea.

Methods: Forty-five strains from 1997, 2006, and 2017, including common emm types, were selected from the repository at Gyeongsang National University Hospital in Korea. Read More

Ann Lab Med 2022 Jul;42(4):428-437

National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P. R. China.

Background: Accurate measurements of serum insulin and C-peptide are needed for the therapy and classification of diabetes. This study investigated the status of serum insulin and C-peptide measurements in China by analyzing the results of five pooled serum samples measured in 94 laboratories.

Methods: Patient serum samples were pooled into five groups according to insulin and C-peptide concentrations and measured in 94 laboratories using different measurement systems. Read More

Ann Lab Med 2022 Jul;42(4):415-427

Department of Preventive Medicine, College of Medicine, Dong-A University, Busan, Korea.

Background: High-density lipoprotein cholesterol (HDL-C) is a well-known predictor of atherosclerotic cardiovascular diseases (ASCVD). We explored the relationships between HDL-C levels and 10-year major adverse cardiovascular events (MACE) and provided sex-specific upper reference limits for HDL-C levels.

Methods: Based on the Korean National Health Insurance Sharing Service, we identified 5,703,897 subjects (women, 48%) with age ≥40 years, eligible HDL-C results, and no prior ASCVD in 2009. Read More

Ann Lab Med 2022 Jul;42(4):406-414

Department of Laboratory Medicine, Korea University Anam Hospital, Seoul, Korea.

Background: Biomarkers and clinical indices have been investigated for predicting mortality in patients with coronavirus disease (COVID-19). We explored the prognostic utility of procalcitonin (PCT), presepsin, and the Veterans Health Administration COVID-19 (VACO) index for predicting 30-day-mortality in COVID-19 patients.

Methods: In total, 54 hospitalized COVID-19 patients were enrolled. Read More