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    2463 results match your criteria Annals of Human Biology [Journal]

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    Dental age estimation in a group of Kenyan children using Willems' method: a radiographic study.
    Ann Hum Biol 2017 Sep 11:1-8. Epub 2017 Sep 11.
    a Department of Human Anatomy, School of Medicine , University of Nairobi , Nairobi , Kenya.
    Background: Radiographic study of developing teeth provides a reliable indication of chronological age. In Kenya, dentists are often required to estimate age. However, there is a paucity of publications on the performance of dental age estimation methods. Read More

    SULT1A1 copy number variation: ethnic distribution analysis in Indian population.
    Ann Hum Biol 2017 Sep 6:1-13. Epub 2017 Sep 6.
    b Sardar Patel University , Vallabh Vidyanagar , Gujarat , India.
    Cytosolic sulfotransferases (SULTs) are phase II detoxification enzymes involved in metabolism of numerous xenobiotics, drugs, and endogenous compounds. Interindividual variation in sulfonation capacity is important for determining an individual's response to xenobiotics. SNPs in SULTs, mainly SULT1A1 have been associated with cancer risk and also with response to therapeutic agents. Read More

    Blood pressure effects of adiposity in non-overweight children aged 6-17 years.
    Ann Hum Biol 2017 Sep 3:1-13. Epub 2017 Sep 3.
    b Suzhou Centers for Disease Control and Prevention , Suzhou , Jiangsu , PR China.
    Obesity is a well-established risk factor of elevated blood pressure; however, the relationships between normal weight status and the risk of hypertension and pre-hypertension are not clear. The aim of this study is to describe the blood pressure effects of adiposity in non-overweight children. 588,097 non-overweight children aged 6-17 years were included from National Surveys on Students' Constitution and Health. Read More

    Biological and environmental determinants of 12-minute run performance in youth.
    Ann Hum Biol 2017 Aug 23:1-7. Epub 2017 Aug 23.
    g Department of Kinesiology and Health Education , University of Texas , Austin , TX , USA.
    Background: The 12-minute run is a commonly used indicator of cardiorespiratory fitness in youth. Variation in growth and maturity status as potential correlates of test performance has not been systematically addressed.

    Aim: To evaluate biological and environmental determinants of 12-minute run performance in Portuguese youth aged 7-17 years. Read More

    Mutation rates for 20 STR loci in a population from São Paulo state, Southeast, Brazil.
    Ann Hum Biol 2017 Sep 11:1-4. Epub 2017 Sep 11.
    a Laboratory of Paternity Investigation , São Paulo State University (UNESP), School of Pharmaceutical Sciences , São Paulo , Brazil.
    Short tandem repeats (STRs) are genetic markers largely employed in forensic analysis and paternity investigation cases. When an inconsistency between the parent and child is considered as a possible mutation, the mutation rate should be incorporated into paternity index calculations to give a robust result and to reduce the chance of misinterpretation. The aim of this study was to estimate the mutation rates of 20 autosomal STRs loci used for paternity tests. Read More

    Prevalence of overweight and obesity in Chinese children and adolescents from 2015.
    Ann Hum Biol 2017 Sep 11:1-2. Epub 2017 Sep 11.
    b Department of Public Health , Zibo Maternal and Child Care Hospital , Zibo , Shandong Province , PR China.
    Background: To update the prevalence of overweight and obesity in children and adolescents from 2015.

    Methods: Data for this study were obtained from children and adolescents aged 7-17 years with measured weight and height from the National Surveys on Chinese Students' Constitution and Health in 2015.

    Results: Measurements from 29 418 children and adolescents (14 480 boys and 14 938 girls) were analysed. Read More

    Testing ecological and universal models of body shape and child health using a global sample of infants and young children.
    Ann Hum Biol 2017 Aug 22:1-7. Epub 2017 Aug 22.
    b School of Human Evolution and Social Change , Arizona State University , Tempe , AZ , USA.
    Aim: To test whether a risk of child illness is best predicted by deviations from a population-specific growth distribution or a universal growth distribution.

    Subjects And Methods: Child weight for height and child illness data from 433 776 children (1-59 months) from 47 different low and lower income countries are used in regression models to estimate for each country the child basal weight for height. This study assesses the extent to which individuals within populations deviate from their basal slenderness. Read More

    Allometric scaling of power-force-velocity ergometry profiles in men.
    Ann Hum Biol 2017 Jul 31:1-4. Epub 2017 Jul 31.
    a Institut du savoir Montfort - Recherche , Ottawa , Ontario , Canada.
    Aim: To examine the appropriate magnitude of allometric scaling of the force-velocity relationship according to body dimensions and to establish normative data for the power-force-velocity relationship for active men.

    Subjects And Methods: Ninety-seven participants completed a force-velocity test on a Monark cycle ergometer. Allometric exponents and percentile ranks were established for maximal power (Pmax), maximal force (F0) and maximal velocity (V0). Read More

    Characterization of complete mitochondrial genomes of indigenous Mayans in Mexico.
    Ann Hum Biol 2017 Aug 22:1-7. Epub 2017 Aug 22.
    b Department of Biological Sciences, Graduate School of Science , The University of Tokyo , Bunkyo-ku , Tokyo , Japan.
    Background: The authors have previously published the complete mitochondrial genome (mitogenome) sequences of two indigenous Mesoamerican populations, Mazahua (n = 25) and Zapotec (n = 88).

    Methods: This study determined the complete mitogenome sequences of nine unrelated individuals from the indigenous Maya population living in Mexico.

    Results: Their mitogenome sequences could be classified into either of the haplogroups A2 and C1. Read More

    Self-reported discomfort associated with Daylight Saving Time in Brazilian tropical and subtropical zones.
    Ann Hum Biol 2017 Aug 23:1-8. Epub 2017 Aug 23.
    f Escola de Artes, Ciências e Humanidades, Universidade de Sao Paulo , Sao Paulo , Brazil.
    Background: Daylight Saving Time (DST) annually moves clocks 1 hour forward, when daytime is longer than night. Previous studies from medium and high latitude locations have pointed to a disruptive effect of DST on human circadian rhythms. Since Brazil is an equatorial country implementing DST, a different relationship between photic and social synchronisers may interfere with DST effects. Read More

    Leprosy in a Lombard-Avar cemetery in central Italy (Campochiaro, Molise, 6th-8th century AD): ancient DNA evidence and demography.
    Ann Hum Biol 2017 Sep 17;44(6):510-521. Epub 2017 Jul 17.
    e Centre for Clinical Microbiology , Division of Infection and Immunity , UCL , London , UK.
    Background: The study of past infectious diseases increases knowledge of the presence, impact and spread of pathogens within ancient populations.

    Aim: Polymerase chain reaction (PCR) was used to examine bones for the presence of Mycobacterium leprae ancient DNA (aDNA) as, even when leprosy is present, bony changes are not always pathognomonic of the disease. This study also examined the demographic profile of this population and compared it with two other populations to investigate any changes in mortality trends between different infectious diseases and between the pre-antibiotic and antibiotic eras. Read More

    Body parameters of Czech breastfed children compared to the Czech references and WHO growth standards.
    Ann Hum Biol 2017 Aug 22:1-7. Epub 2017 Aug 22.
    f Department of Hygiene, Third Faculty of Medicine , Charles University , Prague , Czech Republic.
    Background: The study concerns the comparison of percentile curves of Czech breastfed children with Czech national references from 1991 and 2001 and WHO growth standards. Growth charts of breastfed children demonstrate different curve shapes, especially in the first months of life. Incorrect interpretation of the growth curve could lead to premature introduction of complementary foods or infant formula. Read More

    Bosnian study of APOE distribution (BOSAD): a comparison with other European populations.
    Ann Hum Biol 2017 Sep 13;44(6):568-573. Epub 2017 Jul 13.
    e Department of Human Physiology, Faculty of Medicine , University of Sarajevo , Sarajevo , Bosnia and Herzegovina.
    Background: The ε2, ε3 and ε4 alleles of APOE gene have been associated with several diseases in different populations. Data on the frequency of alleles are used in both a clinical and evolutionary context. Although the data on frequency of these alleles are numerous, there are no reports for the population of Bosnia and Herzegovina. Read More

    The ex-pat effect: presence of recent Western immigrants is associated with changes in age at first birth and birth rate in a Maya population from rural Guatemala.
    Ann Hum Biol 2017 Aug 11;44(5):441-453. Epub 2017 Jul 11.
    d Faculty of Health Sciences , Simon Fraser University , Burnaby , BC , Canada.
    Background: Economic transitions expose indigenous populations to a variety of ecological and cultural challenges, especially regarding diet and stress. These kinds of challenges are predicted by evolutionary ecological theory to have fitness consequences (differential reproduction) and, indeed, are often associated with changes in fertility dynamics. It is currently unclear whether international immigration might impact the nature of such an economic transition or its consequences for fertility. Read More

    Systematic health screening of refugees after resettlement in recipient countries: a scoping review.
    Ann Hum Biol 2017 Aug 31;44(5):475-483. Epub 2017 May 31.
    a Department of Infectious Diseases , Aarhus University Hospital , Aarhus , Denmark.
    Context: Health screening of refugees after settlement in a recipient country is an important tool to find and treat diseases. Currently, there are no available reviews on refugee health screening after resettlement.

    Methods: A systematic literature search was conducted using the online Medical Literature Analysis and Retrieval System ('MEDLINE') database. Read More

    Functional capacities of Polish adults of 60-87 years and risk of losing functional independence.
    Ann Hum Biol 2017 Sep 24;44(6):502-509. Epub 2017 May 24.
    d Department of Kinesiology and Health Education , University of Texas , Austin , TX , USA.
    Aim: To characterise the functional capacities of Polish men and women aged 60-87 years and evaluate their status relative to criteria for functional independence.

    Subjects And Methods: Four hundred and thirty-one women and 125 men, aged 60-87 years, who were residents of Wrocław, southwestern Poland, were recruited. Height and weight were measured and BMI was calculated. Read More

    The influence of migration on dietary practices of Ghanaians living in the United Kingdom: a qualitative study.
    Ann Hum Biol 2017 Aug 13;44(5):454-463. Epub 2017 Jun 13.
    a Public Health Section, School of Health and Related Research-ScHARR , University of Sheffield , Sheffield , UK.
    Background: Previous studies have identified a process of dietary acculturation when migrant groups adopt the food patterns of the host country.

    Aim: The aim of this study was to explore the influence of migration on dietary practices and the process of dietary acculturation amongst Ghanaians living in the UK.

    Subject And Methods: A qualitative study of adults aged ≥25 years (n = 31) of Ghanaian ancestry living in Greater Manchester using face-to-face interviews. Read More

    Quantitative genetics of circulating Hyaluronic Acid (HA) and its correlation with hand osteoarthritis and obesity-related phenotypes in a community-based sample.
    Ann Hum Biol 2017 Sep 9;44(6):522-530. Epub 2017 Jul 9.
    a Human Population Biology Research Unit, Department of Anatomy and Anthropology , Tel Aviv University , Tel Aviv , Israel.
    Background: One of the potential molecular biomarkers of osteoarthritis (OA) is hyaluronic acid (HA). HA levels may be related to the severity and progression of OA. However, little is known about the contribution of major risk factors for osteoarthritis, e. Read More

    Nutritional status and height, weight and BMI centiles of school-aged children and adolescents of 6-18-years from Kinshasa (DRC).
    Ann Hum Biol 2017 Sep 14;44(6):554-561. Epub 2017 Jun 14.
    a Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Laboratory of Kinanthropometry and Exercise Physiology , University of Kinshasa , Kinshasa , Democratic Republic of the Congo.
    Background: The last study to establish centiles of main anthropometric measurements in Kinshasa was conducted over 60 years ago, which questions its current adequacy to describe or monitor growth in this population.

    Aim: To assess the nutritional status of school-aged children and adolescents and to estimate centile curves of height, weight and body mass index (BMI).

    Subjects And Methods: A representative sample of 7541 school-aged children and adolescents (48% boys) aged 6-18 years was measured between 2010-2013. Read More

    Migrating microbes: what pathogens can tell us about population movements and human evolution.
    Ann Hum Biol 2017 Aug 16;44(5):397-407. Epub 2017 May 16.
    d Department of Anthropology & Geography, Human Origins and Palaeoenvironmental Research Group (HOPE) , Oxford Brookes University , Oxford , UK.
    Background: The biology of human migration can be observed from the co-evolutionary relationship with infectious diseases. While many pathogens are brief, unpleasant visitors to human bodies, others have the ability to become life-long human passengers. The story of a pathogen's genetic code may, therefore, provide insight into the history of its human host. Read More

    Alu insertion polymorphisms in the African Sahel and the origin of Fulani pastoralists.
    Ann Hum Biol 2017 Sep 31;44(6):537-545. Epub 2017 May 31.
    f Department of the Archaeology of Landscape and Archaeobiology, Archaeogenetics Laboratory , Institute of Archaeology of the Academy of Sciences of the Czech Republic , Prague , Czech Republic.
    Background: The origin of Western African pastoralism, represented today by the Fulani nomads, has been a highly debated issue for the past decades, and has not yet been conclusively resolved.

    Aim: This study focused on Alu polymorphisms in sedentary and nomadic populations across the African Sahel to investigate patterns of diversity that can complement the existing results and contribute to resolving issues concerning the origin of West African pastoralism.

    Subjects And Methods: A new dataset of 21 Alu biallelic markers covering a substantial part of the African Sahel has been analysed jointly with several published North African populations. Read More

    Relation of socioeconomic status to overweight and obesity: a large population-based study of Chinese adults.
    Ann Hum Biol 2017 Sep 23;44(6):495-501. Epub 2017 May 23.
    a Department of Epidemiology and Biostatistics, School of Public Health , Tianjin Medical University , Tianjin , PR China.
    Background: China has been going through significant changes in social and economical aspects and with great socioeconomic disparity in different regions. However, data on the association between socioeconomic status (SES) and obesity are not available in Tianjin, China.

    Aim: This study aimed to investigate the association between SES and high adiposity among the adult population in Tianjin. Read More

    Comparison between body mass index and a body shape index with adiponectin/leptin ratio and markers of glucose metabolism among adolescents.
    Ann Hum Biol 2017 Sep 25;44(6):489-494. Epub 2017 May 25.
    a Nutrition Department , University of Sao Paulo, School of Public Health , Sao Paulo , Brazil.
    Background: Besides body mass index (BMI), new parameters have been developed to classify individual body shape.

    Aim: To investigate the relationship between BMI, waist circumference (WC), a body shape index (ABSI) and ABSI-adolescents among adolescents and verify which would better predict lower adiponectin/leptin (A/L) ratio and disturbances on glucose metabolism.

    Subjects And Methods: A cross-sectional study with 197 Brazilian adolescents of 14-18 years. Read More

    Chinese Xibe population genetic composition according to linkage groups of X-chromosomal STRs: population genetic variability and interpopulation comparisons.
    Ann Hum Biol 2017 Sep 5;44(6):546-553. Epub 2017 May 5.
    a Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology , Xi'an Jiaotong University , Xi'an , PR China.
    Background: The Xibe population is one of China's officially recognised populations and is now distributed separately from west to east in the northern part of China. X-chromosomal short tandem repeats have a special inheritance pattern, and could be used as complements in forensic application, especially for complex or deficiency cases.

    Subjects And Methods: This study obtained the allelic and haplotypic frequencies of 19 X-STR loci in the Xibe population from Xinjiang Uygur Autonomous Region, China, and studied the genetic differentiations between the Xibe and other populations. Read More

    Prevalence of pre-high blood pressure and high blood pressure among non-overweight children and adolescents using international blood pressure references in developed regions in China.
    Ann Hum Biol 2017 Sep 9;44(6):574-577. Epub 2017 May 9.
    b Suzhou Centers for Disease Control and Prevention , Suzhou , Jiangsu , PR China.
    Background: There is a lack of data on the prevalence of pre-high blood pressure (PreHBP) and high blood pressure (HBP), based on recent international blood pressure references, in non-overweight children and adolescents.

    Aim: To describe the prevalence of PreHBP and HBP in non-overweight children and adolescents in developed regions of China.

    Subjects And Methods: In total, 588 097 non-overweight children and adolescents aged 6-17 years from the National Surveys on Chinese Students' Constitution and Health in 2015 were included. Read More

    Biological aspects of human migration and mobility.
    Ann Hum Biol 2017 Aug;44(5):427-440
    b Department of Human Biology , University of Wroclaw , Wroclaw , Poland.
    This paper reviews how migration, both geographical and social, impacts on variation in some human biological traits. Migration and mobility are considered in relation to anthropometric traits and indices, psychometric traits, health, disease and nutrition, temperature regulation and metabolism, mental health and gene flow. It is well known that migration is important in disease transmission but, as this paper demonstrates, migration can have both positive and negative impacts on both donor and recipient populations for a wide range of human traits. Read More

    Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population.
    Ann Hum Biol 2017 Sep 18;44(6):531-536. Epub 2017 Apr 18.
    a Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene , Alger ; Algérie.
    Background: The arylamine N-acetyltransferase 2 (NAT2) is a key enzyme in the biotransformation of xenobiotics. NAT2 gene polymorphisms have been associated with the risk of isoniazid hepatotoxicity and these polymorphisms change among different populations.

    Aim: The objective of this study is to investigate NAT2 polymorphisms in order to predict the prevalence of NAT2 phenotype in an Algerian population. Read More

    Deep genealogical analysis of a large cohort of participants in the CARTaGENE project (Quebec, Canada).
    Ann Hum Biol 2017 Jun 21;44(4):357-365. Epub 2017 Mar 21.
    a Département des Sciences Humaines et Sociales , Université du Québec à Chicoutimi , Chicoutimi , Québec , Canada.
    Background: Genealogical analysis helps to better understand the genetic structure of populations. The population of Quebec (Canada) often serves as a model for this type of analysis, having one of the world's most complete genealogical databases.

    Aim: The main objective of this study was to reconstruct, analyse and compare the ascending genealogies of participants to CARTaGENE, a project that aims at building a database on various aspects of public health. Read More

    Cardiorespiratory fitness, but not physical activity, is associated with academic achievement in children and adolescents.
    Ann Hum Biol 2017 Jun 3;44(4):309-315. Epub 2017 Apr 3.
    a Research Centre in Physical Activity, Health and Leisure, Faculty of Sport , University of Porto, Portugal , Porto , Portugal.
    Background: Cardiorespiratory fitness (CRF) and physical activity (PA) seem to have positive effects on academic achievement (AA), although in most studies, objective methods of assessment have not been used.

    Aim: To examine the associations of CRF and PA with AA.

    Subjects And Methods: A sample of 640 youngsters (10-18 years) participated in this cross-sectional study. Read More

    Genetic variation of MHC Class I polymorphic Alu insertions (POALINs) in three sub-populations of the East Midlands, UK.
    Ann Hum Biol 2017 Sep 24;44(6):562-567. Epub 2017 Mar 24.
    a Human Genomics Lab , School of Sport, Exercise and Health Sciences, Loughborough University , Loughborough , UK.
    Background: Alu elements are highly researched due to their useful nature as markers in the study of human population genetics. Recently discovered Major Histocompatibility Complex (MHC) polymorphic Alu insertions (POALINs) have not been examined extensively for genetic variation and their HLA associations.

    Aims: The aim of this study is to assess the genetic variation between three populations using five recently discovered POALINs. Read More

    Mitochondrial super-haplogroup U diversity in Serbians.
    Ann Hum Biol 2017 Aug 19;44(5):408-418. Epub 2017 Feb 19.
    a Institute of Molecular Genetics and Genetic Engineering , University of Belgrade , Belgrade , Serbia.
    Background: Available mitochondrial (mtDNA) data demonstrate genetic differentiation among South Slavs inhabiting the Balkan Peninsula. However, their resolution is insufficient to elucidate the female-specific aspects of the genetic history of South Slavs, including the genetic impact of various migrations which were rather common within the Balkans, a region having a turbulent demographic history.

    Aim: The aim was to thoroughly study complete mitogenomes of Serbians, a population linking westward and eastward South Slavs. Read More

    Polymorphism in LRP5 (rs556442) is associated with higher TG levels in Iranian children.
    Ann Hum Biol 2017 Jun 4;44(4):373-378. Epub 2017 Apr 4.
    b Health Policy Research Center, Shiraz University of Medical Sciences , Shiraz , Iran.
    Background: Wnt signalling/LRP5 is involved in adipogenesis by down-regulating adipogenic transcription factors. Therefore polymorphisms in components of this pathway may lead to metabolic disorders.

    Aim: This study tested the impact of LRP5 polymorphism on lipid profile in Iranian children. Read More

    Mitochondrial DNA control region sequences may differentiate Yanbian Koreans in China from other Asian populations.
    Ann Hum Biol 2017 Aug 19;44(5):464-466. Epub 2017 Feb 19.
    a School of Forensic Medicine , China Medical University , Shenyang , PR China.
    Background: Sequence polymorphisms of mitochondrial DNA (mtDNA) are valuable in forensic medicine and anthropological genetics.

    Aim: This study investigated the mtDNA control region sequences in 295 unrelated individuals living in the Yanbian Korean Autonomous Prefecture in the People's Republic of China.

    Subjects And Methods: DNA was extracted from blood stained filter papers. Read More

    Alcohol use disorder and GABAB receptor gene polymorphisms in an Italian sample: haplotype frequencies, linkage disequilibrium and association studies.
    Ann Hum Biol 2017 Jun 14;44(4):384-388. Epub 2017 Feb 14.
    c Department of Biology , University of Rome Tor Vergata , Rome , Italy.
    Background: Alcohol use disorder (AUD) is a complex trait with genetic and environmental influences. Several gene variants have been associated with the risk for AUD, including genes encoding the sub-units of the γ-aminobutyric acid (GABA) receptors.

    Aim: This study evaluated whether specific single nucleotide polymorphisms (SNPs) in genes encoding GABAB receptor sub-units can be considered as candidates for the risk of AUD. Read More

    Urban and rural mortality and survival in Medieval England.
    Ann Hum Biol 2017 Jun 17;44(4):338-348. Epub 2017 Jan 17.
    a Department of Anthropology , University of South Carolina , Columbia , SC , USA.
    Background: Late medieval England underwent intensive urbanisation, particularly in its largest city: London. Urban dwellers were exposed to factors such as high population density, elevated risk of infection, unsanitary living conditions and precarious food supplies.

    Aim: To assess whether the urban environment was more detrimental to health than the rural environment, this study compares risks of mortality and survival, as proxies for health, in medieval urban vs rural England. Read More

    Distribution of xenobiotic metabolising enzyme genotypes in different Tunisian populations.
    Ann Hum Biol 2017 Jun 17;44(4):366-372. Epub 2017 Jan 17.
    b Laboratoire de génétique , immunologie et pathologies Humaine, Faculté des sciences de Tunis, Université de Tunis el Manar , Tunisia.
    Background: The N-acetyltransferase 2 (NAT2) and glutathione transferase enzymes play a crucial role in the metabolism of xenobiotics. Genetic polymorphisms affecting these enzymes can modify their activities with an effect on individual susceptibility for different pathologies. These metabolic phenotypes occur with varying prevalence in different populations. Read More

    Morphology and age-related changes in calcospherites of human teeth: an ultrastructural study.
    Ann Hum Biol 2017 Jun 23;44(4):349-356. Epub 2017 Jan 23.
    c Department of Oral Health Sciences , PGIMER , Chandigarh , India.
    Background: Dentine has been examined extensively for age-related physiological changes, but there are limited data on age-related changes at ultrastructural level of dentine.

    Aim: The present study aimed to examine age-related ultrastructural changes in calcospherites of human dentine under the scanning electron microscope.

    Materials And Methods: Thirty single rooted teeth of North Western adult Indians (18-75 years) were collected from the Department of Oral Health Sciences, PGIMER, Chandigarh. Read More

    Microbiome, growth retardation and metabolism: are they related?
    Ann Hum Biol 2017 May 5;44(3):201-207. Epub 2017 Jan 5.
    b Department of Health Sciences , VU University , Amsterdam , The Netherlands.
    Context: Despite an improvement in food security and the delivery of nutritional supplements to children living in impoverished parts of the world, poor growth is still highly prevalent. Given that the microbiome is related to both nutrient absorption, as well as overweight/obesity, it may play a central role in limiting or modifying normal growth processes while contributing to chronic disease risks.

    Objective: The objective of this paper is to describe normal growth processes, the role of the microbiome in supporting or disrupting normal growth processes, and its potential impact on long-term health. Read More

    Genetics of consanguinity and inbreeding in health and disease.
    Ann Hum Biol 2017 Mar 14;44(2):99-107. Epub 2016 Dec 14.
    a Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences , Aligarh Muslim University , Aligarh , Uttar Pradesh , India.
    Context: Inbreeding increases the level of homozygotes for autosomal recessive disorders and is the major objective in clinical studies. The prevalence of consanguinity and the degree of inbreeding vary from one population to another depending on ethnicity, religion, culture and geography. Global epidemiological studies have revealed that consanguineous unions have been significantly associated with increased susceptibility to various forms of inherited diseases. Read More

    Gene polymorphism profiles of drug-metabolising enzymes GSTM1, GSTT1 and GSTP1 in an Argentinian population.
    Ann Hum Biol 2017 Jun 28;44(4):379-383. Epub 2016 Nov 28.
    a Hematological Genetics Laboratory , Instituto de Medicina Experimental, CONICET-Academia Nacional de Medicina , Ciudad de Buenos Aires , Argentina.
    Background: Glutathione S-transferases (GSTs) are drug-metabolising enzymes involved in biotransformation of carcinogens, drugs, xenobiotics and oxygen free radicals. Polymorphisms of GST genes contribute to inter-individual and population variability in the susceptibility to environmental risk factors, cancer predisposition and pharmacotherapy responses. However, data about GST variability in Argentina are lacking. Read More

    Molecular diversity of 23 Y-chromosome short tandem repeat loci in the population of Tuzla Canton, Bosnia and Herzegovina.
    Ann Hum Biol 2017 Aug 30;44(5):419-426. Epub 2016 Nov 30.
    a Department of Biology, Faculty of Natural Sciences and Mathematics , University of Tuzla , Tuzla , Bosnia and Herzegovina.
    Background: Tuzla Canton is the most populated region in the ethnically mixed territory of Bosnia and Herzegovina, whose genetic analysis could provide an insight into past demographic events.

    Aim: Analysis of 23 Y-chromosome STR markers in the population of Tuzla Canton and investigation of the genetic relationship of the male population of the Tuzla Canton and that of the larger Bosnian and Herzegovinian population as well as neighbouring and other European populations.

    Subjects And Methods: The study was conducted among 100 unrelated healthy adult males from Tuzla Canton that have been genotyped using 23 Y-STR loci included in the PowerPlex Y23 kit. Read More

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