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    442 results match your criteria Annals of General Psychiatry [Journal]

    1 OF 9

    A survey of caregiver burden in those providing informal care for patients with schizophrenia or bipolar disorder with agitation: results from a European study.
    Ann Gen Psychiatry 2018 10;17. Epub 2018 Feb 10.
    3Scientific Department, Ferrer, Barcelona, Spain.
    Background: Agitation is a common feature of bipolar disorder and schizophrenia. Previous research indicates that specific symptoms impact caregiver burden in these conditions, but the impact of agitation on caregiver experience is poorly understood. The aim of this study was to characterise caregiver burden in providers of informal care for patients with bipolar disorder and schizophrenia who experience agitation. Read More

    Off-label prescription of psychiatric drugs by non-psychiatrist physicians in three general hospitals in Germany.
    Ann Gen Psychiatry 2018 8;17. Epub 2018 Feb 8.
    Medical Campus University of Oldenburg, School of Medicine and Health Sciences, Psychiatry and Psychotherapy-University Hospital, Karl-Jaspers-Klinik, Hermann-Ehlers-Straße 7, 26160 Bad Zwischenahn, Germany.
    Background: Off-label prescribing of psychoactive drugs is a common practice in psychiatry. Here, we sought to investigate the frequency of off-label prescribing in a population of hospitalized patients with a somatic illness who were also suffering from a psychiatric pathology.

    Methods: Using a prospective, observational design, we collected data from 982 hospitalized patients with a somatic illness for whom a psychiatric consultation was requested because of the presence of additional psychiatric symptoms. Read More

    Correction to: Psychological and somatic distress in Chinese outpatients at general hospitals: a cross-sectional study.
    Ann Gen Psychiatry 2018 5;17. Epub 2018 Feb 5.
    8Department of Psychosomatics, Medical Division, University Hospital Basel, Basel, Switzerland.
    [This corrects the article DOI: 10.1186/s12991-017-0158-y.]. Read More

    Strength-based assessment for future violence risk: a retrospective validation study of the Structured Assessment of PROtective Factors for violence risk (SAPROF) Japanese version in forensic psychiatric inpatients.
    Ann Gen Psychiatry 2018 30;17. Epub 2018 Jan 30.
    Department of Forensic Psychiatry, National Center Hospital of Neurology and Psychiatry, 4-1-1, Ogawahigashicho, Kodaira, Tokyo 187-8553 Japan.
    Background: The Structured Assessment of PROtective Factors for violence risk (SAPROF) was recently developed as a strength-based addition to the risk assessment of future violent behavior. We examined the interrater reliability and predictive accuracy of the SAPROF for violence in forensic mental health inpatient units in Japan.

    Methods: This retrospective record study provides an initial validation of the SAPROF in a Japanese sample of 95 forensic psychiatric inpatients from a complete 2008-2013 cohort. Read More

    The efficacy, acceptability, and safety of five atypical antipsychotics in patients with first-episode drug-naïve schizophrenia: a randomized comparative trial.
    Ann Gen Psychiatry 2017 22;16:47. Epub 2017 Dec 22.
    Department of Psychiatry, Huaian No. 3 People's Hospital, and Teaching Hospital of Xuzhou Medical University, No. 272 West Huaihai Road, Huai'an, Zip code: 223001 Jiangsu China.
    Background: Differences in effectiveness and tolerability between different atypical antipsychotics may affect schizophrenic patients' treatment adherence or prognosis. However, which kind of antipsychotic was more effective and safe in the treatment of schizophrenia is still being debated. This study attempted to understand whether there are any differences in efficacy, acceptability, and safety between the five atypical antipsychotics in patients with first-episode schizophrenia. Read More

    Continuation with clozapine after eosinophilia: a case report.
    Ann Gen Psychiatry 2017 14;16:46. Epub 2017 Dec 14.
    Department of Psychiatry, Chang-Gung Memorial Hospital at Linkuo, Taoyuan City, Taiwan.
    Background: Clozapine-induced eosinophilia had been reported in several studies about blood dyscrasias in clozapine-treated patient. The largest study with 2404 patients in Italy found the incidence of 2.2% by criteria of more than 0. Read More

    An association study ofandand - polymorphisms in adults with internet gaming disorder: a pilot study.
    Ann Gen Psychiatry 2017 8;16:45. Epub 2017 Dec 8.
    Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, 222, Banpo-daero, Seocho-gu, Seoul, 06591 South Korea.
    Background: Though Internet gaming disorder (IGD) is considered to share similar genetic vulnerability with substance addictions, little has been explored about the role of the genetic variants on IGD. This pilot study was designed to investigate the association of thepolymorphism of the ankyrin repeat and kinase domain containing 1 () gene andand - of the dopamine D2 receptor () with IGD and their role on the personality and temperament traits in IGD among adult population.

    Methods: Sixty-three subjects with IGD and 87 control subjects who regularly played Internet games were recruited. Read More

    Serum prolactin levels and sexual dysfunction in patients with schizophrenia treated with antipsychotics: comparison between aripiprazole and other atypical antipsychotics.
    Ann Gen Psychiatry 2017 28;16:43. Epub 2017 Nov 28.
    Department of Psychiatry, Juntendo University Shizuoka Hospital, 1129 Nagaoka, Izunokunishi, Shizuoka 4102211 Japan.
    Objectives: Antipsychotics, even atypical ones, can induce hyperprolactinemia. Aripiprazole (APZ), a dopamine D2 partial agonist, has a unique pharmacological profile and few side effects. We investigated the incidence of hyperprolactinemia in patients with schizophrenia treated with APZ and other antipsychotics. Read More

    A multilevel longitudinal study of obsessive compulsive symptoms in adolescence: male gender and emotional stability as protective factors.
    Ann Gen Psychiatry 2017 22;16:42. Epub 2017 Nov 22.
    Federation University Australia, Mount Helen, Ballarat, VIC Australia.
    The severity of obsessive compulsive symptoms (OCS) is suggested to be normally distributed in the general population, and they appear to have an impact on a range of aspects of adolescent development. Importantly, there are individual differences regarding susceptibility to OCS. In the present repeated measures study, OCS were studied in relation to gender and emotional stability (as a personality trait) using a normative sample of 515 adolescents at ages 16 and 18 years. Read More

    Association between an angiotensin-converting enzyme gene polymorphism and Alzheimer's disease in a Tunisian population.
    Ann Gen Psychiatry 2017 17;16:41. Epub 2017 Nov 17.
    Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunisia, Mont Fleury, 1008 Tunis, Tunisia.
    Background: The angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D or indel) polymorphism has long been linked to Alzheimer's disease (AD), but the interpretation of established data remains controversial. The aim of this study was to determine whether the angiotensin-converting enzyme is associated with the risk of Alzheimer's disease in Tunisian patients.

    Methods: We analyzed the genotype and allele frequency distribution of the ACE I/D gene polymorphism in 60 Tunisian AD patients and 120 healthy controls. Read More

    Mental, neurologic, and substance use (MNS) disorders among street homeless people in Ethiopia.
    Ann Gen Psychiatry 2017 16;16:40. Epub 2017 Nov 16.
    Research and Training Department, Amanuel Mental Specialized Hospital, PO box: 1971, Addis Ababa, Ethiopia.
    Background: About 25-60% of the homeless population is reported to have some form of mental disorder. To our knowledge, there are no studies aimed at the screening, diagnosis, treatment, care, rehabilitation, and support of homeless people with mental, neurologic, and substance use (MNS) disorders in general in Ethiopia. This is the first study of its kind in Africa which was aimed at screening, diagnosis, care, treatment, rehabilitation, and support of homeless individuals with possible MNS disorder. Read More

    Depression is related to dietary diversity score in women: a cross-sectional study from a developing country.
    Ann Gen Psychiatry 2017 16;16:39. Epub 2017 Nov 16.
    Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Hojatdost Street, Naderi Street, Keshavarz Blv., Tehran, Iran.
    Background: Substantial evidence provides support for the role of diet in the prevention and control of mental disorders. However, since there is no study regarding the relationship between dietary diversity and stress or depression, we aimed to determine the relationship between the dietary diversity score (DDS) and stress and depression in women.

    Methods: This descriptive-analytical cross-sectional study was performed on 360 women aged 20-49 years attending health centers in the south of Tehran. Read More

    Insulin-like growth factor-1: a possible marker for emotional and cognitive disturbances, and treatment effectiveness in major depressive disorder.
    Ann Gen Psychiatry 2017 26;16:38. Epub 2017 Oct 26.
    State Institution "Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine", 20 Winter boulevard, Zaporizhzhia, 69096 Ukraine.
    Depression and cognitive dysfunction share a common neuropathological platform. Abnormal neural plasticity in the frontolimbic circuits has been linked to changes in the expression of neurotrophic factors, including IGF-1. These changes may result in clinical abnormalities observed over the course of major depressive disorder (MDD), including cognitive dysfunction. Read More

    Relationship between the experience of being a bully/victim and mental health in preadolescence and adolescence: a cross-sectional study.
    Ann Gen Psychiatry 2017 18;16:37. Epub 2017 Oct 18.
    Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa Japan.
    Background: Several studies have proven that the experiences of being bullied or bullying others are associated with poor mental health among adolescent youths. Our study aims to investigate the relationship between the experience of the bully/victim and mental health among preadolescents and adolescents.

    Methods: Subjects were the Japanese fifth and sixth grade elementary school students (preadolescents: mean age = 11. Read More

    Weight changes before and after lurasidone treatment: a real-world analysis using electronic health records.
    Ann Gen Psychiatry 2017 17;16:36. Epub 2017 Oct 17.
    Sunovion Pharmaceuticals Inc., Fort Lee, NJ USA.
    Background: Severe and persistent mental illnesses, such as schizophrenia and bipolar disorder, are associated with increased risk of obesity compared to the general population. While the association of lurasidone and lower risk of weight gain has been established in short and longer-term clinical trial settings, information about lurasidone's association with weight gain in usual clinical care is limited. This analysis of usual clinical care evaluated weight changes associated with lurasidone treatment in patients with schizophrenia or bipolar disorder. Read More

    Psychological and somatic distress in Chinese outpatients at general hospitals: a cross-sectional study.
    Ann Gen Psychiatry 2017 16;16:35. Epub 2017 Oct 16.
    Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany.
    Background: Our study aimed (1) to describe the proportion of psychological distress among Chinese outpatients at general hospitals, (2) to compare cognitive and behavioral characteristics of patients with different distress patterns, and (3) to investigate the discriminant function of the analyzed variables in indicating the affinity towards the different distress patterns.

    Methods: This multicenter cross-sectional study was conducted at ten outpatient departments at Chinese general hospitals. The somatic symptom severity scale (PHQ-15), the nine-item depression scale (PHQ-9), and the seven-item anxiety scale (GAD-7) were employed to classify patients in terms of four distress patterns. Read More

    Analysis of EEG entropy during visual evocation of emotion in schizophrenia.
    Ann Gen Psychiatry 2017 25;16:34. Epub 2017 Sep 25.
    Department of Biomedical Engineering, National Cheng Kung University, Tainan, 701 Taiwan.
    Background: In this study, the international affective picture system was used to evoke emotion, and then the corresponding signals were collected. The features from different points of brainwaves, frequency, and entropy were used to identify normal, moderately, and markedly ill schizophrenic patients.

    Methods: The signals were collected and preprocessed. Read More

    Hospital nurses' attitudes, negative perceptions, and negative acts regarding workplace bullying.
    Ann Gen Psychiatry 2017 15;16:33. Epub 2017 Sep 15.
    Research Department, Chi-Mei Medical Center, 901 Chung Hwa Road, Yung Kung Dist., Tainan, 710 Taiwan.
    Background: Workplace bullying is a prevalent problem in today's work places that has adverse effects on both bullying victims and organizations. To investigate the predictors of workplace bullying is an important task to prevent bullying victims of nurses in hospitals.

    Objective: This study aims to explore the relationships among nurses' attitudes, negative perceptions, and negative acts regarding workplace bullying under the framework of the theory of planned behavior (TPB). Read More

    An arabic translation, reliability, and validation of Patient Health Questionnaire in a Saudi sample.
    Ann Gen Psychiatry 2017 6;16:32. Epub 2017 Sep 6.
    SABIC Psychological Health Research & Applications Chair (SPHRAC), College of Medicine, King Saud University, PO Box 242069, Riyadh, 11322 Saudi Arabia.
    Background: Psychological disorders including depression and anxiety are not rare in primary care clinics. The Patient Health Questionnaire (PHQ) is a clinical diagnostic tool that is widely utilized by primary health care physicians worldwide because it provides a practical in-clinic tool to screen for psychological disorders. This study evaluated the validity of the Arabic version of the PHQ in all six modules including depression, anxiety, somatic, panic, eating, and alcohol abuse disorders. Read More

    Effect of lamotrigine in the treatment of bipolar depression with psychotic features: a case report.
    Ann Gen Psychiatry 2017 9;16:31. Epub 2017 Aug 9.
    Department of Neuropsychiatry, Faculty of Life Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto-Shi, Kumamoto 860-8556 Japan.
    Background: Major depressive episodes with psychotic features are more common in bipolar disorder than in major depressive disorder; however, there is little information on the optimal treatment for bipolar depression with psychotic features.

    Case Presentation: The patient was a 69-year-old man. At the age of 66, he was admitted to the hospital for the treatment of bipolar depression with psychotic features. Read More

    Neurological soft signs in Tunisian patients with first-episode psychosis and relation with cannabis use.
    Ann Gen Psychiatry 2017 12;16:30. Epub 2017 Jul 12.
    Psychiatry Department, Fattouma Bourguiba Hospital, 5000 Monastir, Tunisia.
    Background: Neurological soft signs (NSS) are minor non-localizing neurological abnormalities that are conceptualized as neurodevelopmental markers that mediate the biological risk for psychosis. We aimed to explore the relationship between NSS and cannabis use, an environmental risk factor of psychosis.

    Methods: This was a cross-sectional study in consecutively admitted patients hospitalized for first-episode psychosis. Read More

    Leveling and abuse among patients with bipolar disorder at psychiatric outpatient departments in Ethiopia.
    Ann Gen Psychiatry 2017 11;16:29. Epub 2017 Jul 11.
    Psychiatry Department, College of Medicine and Health Science, Bahir Dar University, P.O. Box: 79, Bahir Dar, Ethiopia.
    Introduction: The World Health Organization (WHO) clearly states the importance of psychological well-being in the definition of health as "a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity". However, in the community, the lives of people with bipolar disorders are often harsh and abusive. Till now, the rate and related information concerning verbal or physical abuse among patients with bipolar disorder at psychiatric outpatient clinics have not been well addressed in Ethiopian settings. Read More

    Islam, mental health and law: a general overview.
    Ann Gen Psychiatry 2017 6;16:28. Epub 2017 Jul 6.
    2nd Psychiatry Department, Attikon University Hospital, National and Kapodistrian University of Athens - Medical School, 1 Rimini Street, 12462 Athens, Greece.
    Islam is the dominant religion in about 56 countries around the globe, and has more than 1.2 billion followers. Islam represents a holistic way of life, and according to a large proportion of its followers, the Islamic law or Shari'ah should prevail over secular law and should be implemented as state law. Read More

    A new technique to measure online bullying: online computerized adaptive testing.
    Ann Gen Psychiatry 2017 3;16:26. Epub 2017 Jul 3.
    Research Department, Chi-Mei Medical Center, 901 Chung Hwa Road, Yung Kung Dist., Tainan, 710 Taiwan.
    Background: Workplace bullying has been measured in many studies to investigate mental health issues. None uses online computerized adaptive testing (CAT) with cutting points to report bully prevalence at workplace.

    Objective: To develop an online CAT to examine person being bullied and verify whether item response theory-based CAT can be applied online for nurses to measure exposure to workplace bullying. Read More

    Amisulpride withdrawal dyskinesia: a case report.
    Ann Gen Psychiatry 2017 14;16:25. Epub 2017 Jun 14.
    Bali Psychiatric Center, No. 33, Huafushan, Bali Dist., New Taipei City, 24936 Taiwan.
    Background: The effects of antipsychotic drug withdrawal have been inadequately studied. Case reports have described dyskinesia occurring in patients with several antipsychotics withdrawn, but studies on amisulpride withdrawal dyskinesia are lacking.

    Case Presentation: A 63-year-old man, who was diagnosed with schizophrenia at age 49, received amisulpride treatment since age 62. Read More

    A case report of Lhermitte-Duclos disease revealed by psychiatric disturbances.
    Ann Gen Psychiatry 2017 30;16:24. Epub 2017 May 30.
    Psychiatry Department, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
    Background: Lhermitte-Duclos disease (LDD) is a rare cerebellar lesion characterized by a hamartomatous lesion in the posterior fossa. Mainly diagnosed by MRI, the clinical presentation is usually made of neurological symptoms.

    Case Presentation: We present here a rare case of a woman who developed depressive symptoms that inaugurated the clinical presentation of LDD. Read More

    Treatment modalities for patients with gambling disorder.
    Ann Gen Psychiatry 2017 28;16:23. Epub 2017 Apr 28.
    Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul, 08308 South Korea.
    Background: Gambling disorder (GD) is defined as persistent and recurrent problematic gambling behavior leading to clinically significant impairment or distress. The prevalence of GD has been shown to be 1.2-7. Read More

    Screening of Wilson's disease in a psychiatric population: difficulties and pitfalls. A preliminary study.
    Ann Gen Psychiatry 2017 4;16:19. Epub 2017 Apr 4.
    Laboratory of Inherited Metabolic Diseases, Centre de Biologie Est, Hospices Civils de Lyon, Bron, France.
    Background: Wilson's disease (WD) is a rare autosomal-recessive, inherited disorder caused by a mutation in the copper-transporting geneaffecting the liver and nervous system. About 30% of patients with WD may initially present with psychiatric symptoms, and diagnosis can be difficult to establish. The objectives of the present preliminary study were [1] to evaluate the relevance of serum copper (Cu) and ceruloplasmin (Cp) measures in hospitalized patients with psychiatric disorders; and [2] to identify possible mutations in thegene in patients with abnormal biological copper profile. Read More

    Lifestyle factors and the metabolic syndrome in Schizophrenia: a cross-sectional study.
    Ann Gen Psychiatry 2017 15;16:12. Epub 2017 Feb 15.
    Department of Blood Sciences, Walsall Manor Hospital, Walsall, WS2 9PS UK.
    Background: Cardiometabolic disease is more common in patients with schizophrenia than the general population.

    Aim: The purpose of the study was to assess lifestyle factors, including diet and exercise, in patients with schizophrenia and estimate the prevalence of metabolic syndrome.

    Methods: This is a cross-sectional study of a representative group of outpatients with schizophrenia in Salford, UK. Read More

    Erratum to: Agonist Opioid Treatment as historical comprehensive treatment ('Dole & Nyswander' methodology) is associated with better toxicology outcome than Harm Reduction Treatment.
    Ann Gen Psychiatry 2017 13;16:10. Epub 2017 Feb 13.
    Vincent P. Dole Dual Diagnosis Unit, Department of Neurosciences, Santa Chiara University Hospital, University of Pisa, Via Roma, 67 56100 Pisa, Italy.
    [This corrects the article DOI: 10.1186/s12991-016-0109-z.]. Read More

    Smoking and antidepressants pharmacokinetics: a systematic review.
    Ann Gen Psychiatry 2017 6;16:17. Epub 2017 Mar 6.
    Psychiatry Department, Coimbra Hospital University Centre, Praceta Mota Pinto, 3000-075 Coimbra, Portugal.
    Background: Despite an increasingly recognized relationship between depression and smoking, little is known about how smoking influences antidepressant response and treatment outcomes. The aim of this study was to systematically review the evidence of the impact of smoking on new-generation antidepressants with an emphasis on the pharmacokinetic perspective.

    Methods: We present a systematic review of clinical trials comparing the serum levels of new-generation antidepressants in smokers and nonsmokers. Read More

    Knowledge of and attitudes towards electroconvulsive therapy (ECT) among psychiatrists and family physicians in Saudi Arabia.
    Ann Gen Psychiatry 2017 28;16:16. Epub 2017 Feb 28.
    Department of Internal Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.
    Objectives: To assess the knowledge of and attitudes towards ECT among psychiatrists and family physicians in Saudi Arabia.

    Methods: The study is quantitative observational cross-sectional with a convenient sample that included psychiatrists and family physicians (including residents) in Saudi Arabia.

    Results: Of the 434 questionnaires emailed, a total of 126 returned completed questionnaires (29% response rate). Read More

    Insomnia severity and its relationship with demographics, pain features, anxiety, and depression in older adults with and without pain: cross-sectional population-based results from the PainS65+ cohort.
    Ann Gen Psychiatry 2017 23;16:15. Epub 2017 Feb 23.
    Pain and Rehabilitation Centre, Department of Medical and Health Sciences (IMH), Linköping University, 581 85 Linköping, Sweden.
    Background: Insomnia is a major cause of concern in the elderly with and without pain. This study set out to examine the insomnia and its correlates in a large sample of community adults aged ≥65 years.

    Methods: A cross-sectional postal survey was completed by 6205 older individuals (53. Read More

    The effects of probiotics on depressive symptoms in humans: a systematic review.
    Ann Gen Psychiatry 2017 20;16:14. Epub 2017 Feb 20.
    Department of Psychiatry, Queen's University, 752 King Street West, Kingston, ON K7L 4X3 Canada.
    Background: Patients suffering from depression experience significant mood, anxiety, and cognitive symptoms. Currently, most antidepressants work by altering neurotransmitter activity in the brain to improve these symptoms. However, in the last decade, research has revealed an extensive bidirectional communication network between the gastrointestinal tract and the central nervous system, referred to as the "gut-brain axis. Read More

    Prevalence and effect of attention-deficit/hyperactivity disorder on school performance among primary school pupils in the Hohoe Municipality, Ghana.
    Ann Gen Psychiatry 2017 14;16:11. Epub 2017 Feb 14.
    Department of Population and Behavioural Sciences, School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana.
    Background: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common disorders in early childhood. However, not many studies have been conducted on the prevalence and effect of ADHD on school performance in Ghana. This study sought to ascertain the prevalence of ADHD and its effect on school performance among primary school pupils in the Hohoe municipality of Ghana. Read More

    Cardiometabolic comorbidities, readmission, and costs in schizophrenia and bipolar disorder: a real-world analysis.
    Ann Gen Psychiatry 2017 10;16. Epub 2017 Feb 10.
    Sunovion Pharmaceuticals Inc., Fort Lee, NJ USA.
    Background: Serious mental illnesses are associated with increased risk of cardiometabolic comorbidities. The objective of this study was to evaluate the prevalence of cardiometabolic comorbidity and its association with hospitalization outcomes and costs among inpatients with schizophrenia or bipolar disorder.

    Methods: This retrospective database analysis reviewed patients with an inpatient diagnosis of schizophrenia or bipolar disorder from the Premier Perspective® Database (4/1/2010-6/30/2012). Read More

    A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients.
    Ann Gen Psychiatry 2017 17;16. Epub 2017 Jan 17.
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, Japan.
    Background: Clinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuroanatomical abnormalities in OCD patients. In the etiopathogenesis of OCD, few studies have performed concurrent assessment of genetic and neuroanatomical variables.

    Methods: We carried out a two-way ANOVA between a variable number of tandem repeat polymorphisms (5-HTTLPR) in the serotonin transporter gene and gray matter (GM) volumes in 40 OCD patients and 40 healthy controls (HCs). Read More

    HLA DRB1*03 as a possible common etiology of schizophrenia, Graves' disease, and type 2 diabetes.
    Ann Gen Psychiatry 2017 2;16. Epub 2017 Feb 2.
    Laboratoire de Biologie Moléculaire, Service d'Hématologie., Hôpital Militaire de Tunis, Montfleury, 1008 Tunis, Tunisia.
    Background: Autoimmune diseases and schizophrenia share many common features. Association studies confirm a shared genetic association in the human leukocyte antigen (HLA) region between schizophrenia and most autoimmune diseases. To our knowledge, the simultaneous syndromes of Graves' disease (GD) and type 2 diabetes (T2D) in schizophrenia are rare in Tunisia. Read More

    Preventing involuntary admissions: special needs for distinct patient groups.
    Ann Gen Psychiatry 2017 25;16. Epub 2017 Jan 25.
    Dept. of Psychiatry, LWL Institute of Mental Health, LWL University Hospital, Ruhr-University Bochum, Alexandrinenstr.1, 44791 Bochum, Germany.
    Background: Coercive measures in psychiatry are a controversial topic and raise ethical, legal and clinical issues. Involuntary admission of patients is a long-lasting problem and indicates a problematic pathway to care situations within the community, largely because personal freedom is fundamentally covered by the UN declaration of human rights and the German constitution.

    Methods: In this study, a survey on a large and comprehensive population of psychiatric in-patients in the eastern part of North Rhine-Westphalia, Germany, was carried out for the years 2004-2009, including 230. Read More

    Antidepressive response of inpatients with major depression to adjuvant occupational therapy: a case-control study.
    Ann Gen Psychiatry 2017 3;16. Epub 2017 Jan 3.
    Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinenstr. 1-3, 44791 Bochum, Germany.
    Background: Despite marked costs and limited evidence regarding effectiveness, occupational therapy (OT) is widely applied in psychiatric settings and financed by health insurance companies in European countries. This pilot study investigated the antidepressive effects of adjuvant OT for patients with major depression in a 6-week inpatient setting, stratified for females and males.

    Methods: A total of 114 inpatients with major depression were assigned to either a standard OT group (using basic handcraft) or an active control group that played board games (2 h daily, 5 days a week). Read More

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