2,070 results match your criteria Annals of Diagnostic Pathology[Journal]


Histologic diversity in chromophobe renal cell carcinoma does not impact survival outcome: A comparative international multi-institutional study.

Ann Diagn Pathol 2022 May 20;60:151978. Epub 2022 May 20.

Department of Pathology, Charles University, Faculty of Medicine and University Hospital in Plzen, Plzen, Czech Republic. Electronic address:

Predicting the clinical behavior and trajectory of chromophobe renal cell carcinoma (ChRCC) by histologic features has so far proven to be challenging. It is known that ChRCC represents a heterogeneous group of neoplasms demonstrating variable, yet distinctive morphologic and genetic profiles. In this international multi-institutional study, we aimed to assess the impact of histologic diversity in ChRCC (classic/eosinophilic versus rare subtypes) on survival outcome. Read More

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Cyto-histologic correlation of crystal-storing histiocytosis: Rare presentation in breast, predating diagnosis of B-cell lymphoma by two years.

Ann Diagn Pathol 2022 May 18;59:151979. Epub 2022 May 18.

Department of Laboratory Medicine and pathology, Mayo Clinic, Rochester, USA.

Crystal-storing histiocytosis (CSH) is a rare disorder characterized by the accumulation of crystalized immunoglobulins within the cytoplasm of histiocytes. It is often associated with an underlying lymphoproliferative or plasma cell disorder. Most patients with CSH are asymptomatic in regard to the disease and are incidentally discovered. Read More

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Mucinous cystadenoma of the liver with pathological-radiological correlation.

Ann Diagn Pathol 2022 May 18;59:151977. Epub 2022 May 18.

Department of Histology and Embryology, Faculty of Medicine Novi Sad, University of Novi Sad, Serbia. Electronic address:

The paper presents a pathological-radiological correlation of the manifestation of mucosal cystadenoma with ovarian stroma of the liver with examination and correlation with the new stroma nomenclature and differential diagnostic dilemmas of radiologists and pathologists. Read More

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Exploring the pathophysiologic basis of constrictive pericarditis of Kohlmeier Degos disease: A case series and review of the literature.

Ann Diagn Pathol 2022 Mar 28;59:151943. Epub 2022 Mar 28.

Department of Medicine, Albany Medical Center, Albany, NY, United States of America.

Kohlmeier-Degos Disease is a unique thrombotic microvascular and arteriopathic vasculopathy that is highly selective in the organs it targets. It invariably involves the skin and can be a purely cutaneous process. It affects both the microvasculature and the arterial system ranging from a thrombogenic microangiopathy to a fibrointimal obliterative arteriopathy with an accompanying background of extravascular fibrosis. Read More

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Useful histopathologic features for diagnosing focal liver lesions with spindle cell morphology: A clinicopathologic study.

Ann Diagn Pathol 2022 May 10;59:151975. Epub 2022 May 10.

Department of Pathology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: Focal liver lesions with spindle cell morphology are rare in the daily practice of pathology. The differential diagnosis is broad, including both tumors and tumor-like lesions. Initial radiologic assessment is sometimes inaccurate. Read More

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Extrauterine endometrial stromal sarcoma: A systematic review and outcome analysis.

Ann Diagn Pathol 2022 May 10;59:151966. Epub 2022 May 10.

Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address:

Endometrial stromal sarcoma (ESS) is the second most common uterine mesenchymal neoplasm. ESS can arise from extrauterine locations without any uterine involvement and is called extrauterine ESS (EESS). The epidemiological features of EESS are not well-known. Read More

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Evaluation of Lipocalin-2 and Twist expression in thyroid cancers and its relationship with epithelial mesenchymal transition.

Ann Diagn Pathol 2022 May 10;59:151973. Epub 2022 May 10.

Department of Pathology, Ankara Training and Research Hospital, Ankara, Turkey.

Objective: To evaluate the expressions of lipocalin-2 (LCN-2) and Twist in thyroid cancers and examine its relationship with epithelial-to-mesenchymal transition (EMT) and clinicopathological factors.

Materials And Methods: The expression of LCN-2 and Twist was immunohistochemically evaluated in a total of 249 cases, including 120 patients with papillary thyroid carcinomas (PTC), 34 with follicular thyroid carcinoma (FTC), 15 with medullary thyroid carcinomas (MTC), 20 with non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 47 with follicular adenomas (FA), and 13 with nodular hyperplasia (NH). In addition, the relationship between the expression of EMT markers E-cadherin and vimentin was investigated in malignant cases. Read More

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PCR-based analysis of PD-L1 RNA expression in lung cancer: comparison with commonly used immunohistochemical assays.

Ann Diagn Pathol 2022 May 6;59:151968. Epub 2022 May 6.

N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia; St.-Petersburg Pediatric Medical University, St.-Petersburg 194100, Russia; I.I. Mechnikov North-Western Medical University, St.-Petersburg 191015, Russia.

Background: PD-L1 testing is currently performed by immunohistochemistry (IHC). We questioned whether the results of PCR-based measurement of PD-L1 RNA expression correlate with IHC scores obtained by different commercial assays.

Materials And Methods: 167 consecutive non-squamous non-small cell lung carcinomas (NSCLCs) were analyzed for PD-L1 RNA expression and 22C3, SP263, and SP142 IHC scoring using recommended cut-offs. Read More

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Loss of dimethylated H3K27 (H3K27me2) expression is not a specific marker of malignant peripheral nerve sheath tumor (MPNST): An immunohistochemical study of 137 cases, with emphasis on MPNST and melanocytic tumors.

Ann Diagn Pathol 2022 May 6;59:151967. Epub 2022 May 6.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 59005, United States of America. Electronic address:

Introduction: Loss-of-function mutations in EED and SUZ12, core components of the polycomb repressive complex 2 (PRC2), occur in >90% of sporadic and radiation-associated malignant peripheral nerve sheath tumors (MPNST) and in roughly 70% of NF1-related tumors. PRC2 inactivation results in loss of H3K27me3 expression and aberrant downstream transcription. H3K27me3 expression is lost in 40-90% of spindle cell MPNST but is not specific. Read More

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Association of ZEB1 and Vimentin with poor prognosis in metaplastic breast cancer.

Ann Diagn Pathol 2022 Apr 22;59:151954. Epub 2022 Apr 22.

Department of Biology, Laboratory of Mycology, Pathologies and Biomarkers (LR16ES05), Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia.

Zinc finger E-box binding homeobox factor 1 (ZEB1) is a transcription factor involved in the epithelial to mesenchymal transition (EMT) process of metaplastic breast cancer (MBC). This study aimed to assess the expression of ZEB1 in MBC and explore its association with clinicopathological factors and prognosis. We analyzed the immunohistochemical expression of ZEB1 in 50 MBC tissue samples. Read More

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Inverse co-expression of EZH2 and acetylated H3K27 in prostatic tissue.

Ann Diagn Pathol 2022 Apr 27;59:151956. Epub 2022 Apr 27.

Departments of Pathology, Milwaukee, WI, United States of America. Electronic address:

Context: Enhancer of Zeste 2 (EZH2), a methyltransferase and an upregulated gene is an adverse prognosticator in prostate cancer. It catalyzes histone H3 lysine 27 trimethylation (H3K27me3) leading to repressive chromatin status (heterochromatin). Following demethylation and acetylation of H3 protein (H3K27ac) the result is transcriptionally activated status (euchromatin), a key metastasis facilitator being targeted by ongoing clinical trials, as with palbociclib. Read More

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EWSR1 rearrangement is not specific for hyalinizing clear cell carcinoma of salivary glands.

Ann Diagn Pathol 2022 Mar 31;59:151946. Epub 2022 Mar 31.

Department of Pathology, College of Medicine, King Saud University, Saudi Arabia. Electronic address:

Objective: In this study, we investigate the molecular rearrangement of EWSR1 in hyalinizing clear cell carcinoma (HCCC) (with and without eosinophilia) and clear cell variant of mucoepidermoid carcinoma (MEC) of salivary glands.

Method: We performed a molecular detection of HCCC (Group 1) and clear cell variant of MEC (Group 2). Group 1 consisted of 5 cases of typical HCCC and 5 cases of HCCC with eosinophilia. Read More

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Primary mediastinal germ cell tumor and clonally related and unique hematologic neoplasms with i(12p) and TP53 mutation: A report of two cases.

Ann Diagn Pathol 2022 Apr 20;59:151951. Epub 2022 Apr 20.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America. Electronic address:

The development of clonally related hematologic neoplasms in the setting of primary mediastinal germ cell tumors (PMGCTs) has been recognized previously and is associated with a dismal prognosis. However, the presentation of hematologic neoplasms as chronic myelomonocytic leukemia (CMML) and hemophagocytic lymphohistiocytosis (HLH) has been rarely reported. Here we report two patients with PMGCTs and hematologic neoplasms. Read More

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HER2 testing in metastatic breast cancer - Is reflex ISH testing necessary on HER2 IHC-equivocal (2+) cases?

Ann Diagn Pathol 2022 Apr 21;59:151953. Epub 2022 Apr 21.

Department of Pathology and Laboratory Medicine, Dalhousie University, Halifax, NS, Canada; Nova Scotia Health Authority, Halifax, NS, Canada. Electronic address:

Current guidelines recommend HER2 testing on all primary invasive breast cancers and re-biopsy at disease relapse. The discordance rate between HER2-negative primaries and HER2 IHC2+ metastases that are ISH-amplified is unknown. We hypothesize that the majority of such cases are non-amplified. Read More

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Comparison of bone marrow trephine sample quality between a drill-powered system and a manual needle system.

Ann Diagn Pathol 2022 Apr 20;59:151952. Epub 2022 Apr 20.

Department of Clinical Haematology, Centre Henri Becquerel, Rouen 76038, France. Electronic address:

Context: Bone marrow biopsy (BMB) is a common procedure in haematology used for the diagnosis and evaluation of response treatment. Because the procedure is difficult for haematologists to perform, patients often experience pain and stress. On Control, a system device, was introduced in the 2000s and uses a drill-powered needle to perform BMB. Read More

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Sclerosing polycystic adenoma - A review.

Ann Diagn Pathol 2022 Apr 9;59:151949. Epub 2022 Apr 9.

Department of Pathology, National University Health System, Singapore. Electronic address:

This review summarizes the current state of knowledge on sclerosing polycystic adenoma, including epidemiological/clinical, histopathological/cytopathological, ultrastructural, immunohistochemical and etiopathogenetic/molecular genetic aspects. Differential diagnostic issues are briefly discussed. Read More

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Revisiting the necessity for routine appendectomies in mucinous neoplasms of the ovary: An evaluation of 460 mucinous ovarian tumors.

Ann Diagn Pathol 2022 Apr 9;59:151950. Epub 2022 Apr 9.

Department of Pathology, University of California San Diego, La Jolla, CA, United States of America. Electronic address:

Appendectomies are not uncommonly performed following an intraoperative diagnosis of a mucinous ovarian neoplasm, although the evidentiary basis for the practice is relatively limited. The current study is a contemporary re-examination of the issue, based on an analysis of a large single institutional cohort. We assessed whether there are any composite of factors that may be associated with the finding of significant disease in the appendix in this setting following intraoperative consultation (IOC) diagnosis of a mucinous neoplasm on an ovary-based mass. Read More

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Small cell carcinoma of the urinary bladder: Distinctive cytological characteristics and Cyto-histologic correlation.

Ann Diagn Pathol 2022 Apr 9;59:151947. Epub 2022 Apr 9.

Medical College of Wisconsin, Pathology Department, Milwaukee, WI, USA. Electronic address:

Preoperative diagnosis in liquid-based cytology preparation in voided urine specimen and cyto-histologic correlation of small cell carcinoma of the urinary bladder has not been described in detail in the literature. A 79-year old male presented at our institution with gross hematuria. He was accurately diagnosed with small cell carcinoma of the bladder on liquid-based cytology in urine. Read More

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Diagnostic accuracy of fine needle aspiration cytology and core needle biopsy in bone and soft tissue tumor: A comparative study of the image-guided and blindly performed procedure.

Ann Diagn Pathol 2022 Mar 18;59:151936. Epub 2022 Mar 18.

Department of Orthopedic Surgery, Uonuma Kikan Hospital, Japan.

Introduction: Fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) can provide tissue samples for the diagnoses of bone and soft tissue tumors. We evaluated the diagnostic accuracy of FNAC and CNB, the usefulness of the image-guided needle procedures, and assessed whether a discordance can influence the prognosis.

Patients And Methods: We retrospectively examined the accuracy rates of FNAC and CNB procedures by analyzing results of 405 specimens of 389 patients. Read More

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The value of 'raspberry bodies' in intraoperative cytologic evaluation of adnexal masses for the diagnosis of clear cell carcinoma of the ovary: A cytological-pathological correlation.

Ann Diagn Pathol 2022 Apr 4;59:151948. Epub 2022 Apr 4.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

We report a case of a 48-year-old female who presented to the emergency department with pelvic/abdominal pain and a recent history of irregular periods. Pelvic ultrasound and computed tomography (CT) scan of the abdomen/pelvis revealed a 7.3 cm adnexal mass with suspicious features. Read More

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Impact of minimal solid and micropapillary components on invasive lung adenocarcinoma recurrence.

Ann Diagn Pathol 2022 Apr 1;59:151945. Epub 2022 Apr 1.

Department of Cardio-Thoracic Surgery, Zhoushan Hospital, 739 Dingshen Road, Zhoushan, Zhejiang 316000, PR China. Electronic address:

Background: The specific impacts of solid and micropapillary components on prognosis in lung adenocarcinoma remain unclear. Herein, we elucidated their distinct contributions to lung adenocarcinoma recurrence.

Materials And Methods: Lung adenocarcinoma was classified into solid and micropapillary absent (S-M-); solid absent, micropapillary present (S-M+); micropapillary absent, solid present (S + M-); and solid and micropapillary present (S + M+). Read More

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Juvenile and adult xanthogranuloma: A 30-year single-center experience and review of the disorder and its relationship to other histiocytoses.

Ann Diagn Pathol 2022 Jun 30;58:151940. Epub 2022 Mar 30.

Lauren V. Ackerman Laboratory of Surgical Pathology, Barnes Jewish/St. Louis Children's Hospitals, Washington University Medical Center, St. Louis, MO, USA. Electronic address:

Background: Juvenile xanthogranuloma (JXG) is the most common type of non-Langerhans cell histiocytosis whose cell of origin, etiology and pathogenesis are not fully understood. We aimed to provide an update on histopathologic and immunophenotypic profile of this well-characterized entity whose relationship to the other histiocytoses has received renewed attention in light of recent molecular genetic studies.

Materials And Methods: A retrospective review of all the cases with the pathologic diagnosis of "xanthogranuloma" was performed on our archives from 1989 to 2019. Read More

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Primary follicular dendritic cell sarcoma of the pleura: A clinicopathological and immunohistochemical study of two cases.

Ann Diagn Pathol 2022 Jun 28;58:151944. Epub 2022 Mar 28.

Department of Laboratory Medicine, University of Texas, M D Anderson Cancer Center, Houston, TX, USA. Electronic address:

Two cases of primary follicular dendritic cell sarcoma (FDCS) of the pleura are presented. The patients are a woman 76-years-old and a man 64-years-old who presented with nonspecific symptoms including chest pain, dyspnea, and cough. Clinical history did not disclose any pertinent history of previous malignancy. Read More

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The relationship of tumor budding with GOLPH3 expression and histopathological prognostic parameters in colorectal adenocarcinoma.

Ann Diagn Pathol 2022 Jun 3;58:151933. Epub 2022 Mar 3.

Department of General Surgery, University of Health Sciences Turkey, Gaziosmanpaşa Training and Research Hospital, İstanbul, Turkey.

Objective: Tumor budding is an independent poor prognostic parameter in colorectal carcinoma (CRC). Golgi phosphoprotein 3 (GOLPH3) has been investigated in many solid organ tumors and has been associated with poor prognosis. In this study, the relationship of tumor budding and GOLPH3 and histopathological prognostic markers was investigated. Read More

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Identification of EWSR1 rearrangements in patients with immature hematopoietic neoplasms: A case series and review of literature.

Ann Diagn Pathol 2022 Jun 23;58:151942. Epub 2022 Mar 23.

Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

Rearrangement of the EWSR1 gene (22q12.2) is a well-recognized genetic lesion in bone and soft tissue tumors. However, few reports have suggested that EWSR1 rearrangements may also occur in the setting of hematopoietic tumors. Read More

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Superficial CD34-positive fibroblastic tumor (SCPFT): A review of pathological and clinical features.

Ann Diagn Pathol 2022 Jun 24;58:151937. Epub 2022 Mar 24.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, United States of America. Electronic address:

Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described rare mesenchymal tumor of borderline malignancy. It generally involves superficial soft tissue, with a predilection to the lower extremities. Microscopically this tumor is characterized by a fascicular and storiform growth pattern, spindled to epithelioid cells, nuclear atypia with pleomorphism, and eosinophilic granular, and fibrillar to glassy cytoplasm. Read More

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Reply to Editor.

Ann Diagn Pathol 2022 Jun 21;58:151939. Epub 2022 Mar 21.

Department of Pathology, British Columbia Cancer Vancouver Centre, Vancouver, BC, Canada; University of British Columbia, Vancouver, BC, Canada. Electronic address:

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Impact of the updated 2018 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines on Human Epidermal Growth Factor Receptor 2 (HER2) gene testing in invasive breast cancers: A single center study.

Ann Diagn Pathol 2022 Jun 18;58:151935. Epub 2022 Mar 18.

Division of Pathology, Singapore General Hospital, Singapore.

The study aimed to evaluate the impact of the updated 2018 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines on Human Epidermal Growth Factor Receptor 2 (HER2) testing in invasive breast cancer compared with previous 2013 guidelines. Between Jan 2014 and May 2020, 3364 consecutive invasive breast carcinomas with concurrent HER2 immunohistochemistry (IHC) and fluorescence in-situ hybridization (FISH) results were retrospectively reviewed for HER2 status. Both 2013 and 2018 testing criteria were applied to establish the HER2 status. Read More

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From the archives of MD Anderson Cancer Center: Intravascular large B-cell lymphoma with numerous circulating lymphoma cells.

Ann Diagn Pathol 2022 Jun 10;58:151934. Epub 2022 Mar 10.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America. Electronic address:

Intravascular large B-cell lymphoma (IVLBCL) is a rare, clinically aggressive form of large B-cell lymphoma that is preferentially located within blood vessel lumina. Despite its intravascular location, a leukemic phase of disease seems to be uncommon. After encountering a patient with IVLBCL with numerous circulating lymphoma cells, we reviewed the literature and identified 6 patients with IVLBCL who had numerous circulating lymphoma cells (defined by ≥10% lymphoma cells in peripheral blood). Read More

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