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    1458 results match your criteria Annals of Diagnostic Pathology [Journal]

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    Three cases of adrenocortical tumors mistaken for hepatocellular carcinomas/diagnostic pitfalls and differential diagnosis.
    Ann Diagn Pathol 2017 Dec 29;31:9-13. Epub 2017 May 29.
    Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Republic of Korea; BioMedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. Electronic address:
    Adrenocortical adenomas and carcinomas in other parenchyma are extremely rare, with few cases reported and because of the rarity of these tumors, they occasionally cause problems during diagnosis. Adrenal cortical neoplasms in liver parenchyma can be present in 3 forms, including direct invasion or adhesion to liver parenchyma, tumors arising in adrenohepatic fusion tissue or in ectopic adrenal gland tissue. We report 3 cases of adrenal cortical tumors that were misdiagnosed as hepatocellular carcinoma in the preoperative state. Read More

    Sarcoid-like granulomas in renal cell carcinoma: The Houston Methodist Hospital experience.
    Ann Diagn Pathol 2017 Dec 29;31:62-65. Epub 2017 Jul 29.
    Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, United States. Electronic address:
    Sarcoid-like (SL) granulomas have been previously described in association with malignant tumors. These granulomas appear to be tumor-related but are not indicative of systemic sarcoidosis, and hence are referred to as SL reactions. These SL reactions can be seen within the primary tumor, its vicinity, or in uninvolved sites such as the spleen, bone marrow, skin, and/or regional lymph nodes draining the tumor. Read More

    Clinicopathologic correlation of programmed death ligand-1 expression in non-small cell lung carcinomas: A report from India.
    Ann Diagn Pathol 2017 Dec 14;31:56-61. Epub 2017 Jul 14.
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:
    Introduction: Increased expression of Programmed death ligand-1 (PD-L1) on cancer cells and immune cells predict response to PD-1/PDL1 inhibitors. Data regarding frequency and pattern of PD-L1 expression in NSCLC from India is not available.

    Objectives: To analyse PD-L1 expression on tumour cells (TC) and immune cells (IC) and to correlate PD-L1 expression with baseline clinico-pathological characteristics, oncogenic drivers and outcome data. Read More

    Oral Lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma.
    Ann Diagn Pathol 2017 Dec 16;31:50-55. Epub 2017 Jun 16.
    Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:
    Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. Read More

    Methylation-associated silencing of SFRP1 gene in high-grade serous ovarian carcinomas.
    Ann Diagn Pathol 2017 Dec 15;31:45-49. Epub 2017 Jul 15.
    Department of Biology, School of Medicine, University of Zagreb, Zagreb, Croatia.
    Wnt is a highly conserved signaling pathway responsible for tissue regeneration, maintenance and differentiation of stem cells in adults. Its aberrant activation through reduced expression of Wnt signaling pathway inhibitors, such as proteins from the SFRP family, is commonly seen in many tumors. In the present study we explored SFRP1 protein expression using immunohistochemistry in 11 low-grade serous ovarian carcinomas (LGSC), 42 high-grade serous ovarian carcinomas (HGSC), and 5 normal ovarian tissues (controls). Read More

    Comparison of HER2 status determination methods in HER2 (2+) patients: Manual fluorescent in situ hybridization (FISH) vs. dual silver enhanced in situ hybridization (SISH).
    Ann Diagn Pathol 2017 Dec 24;31:36-40. Epub 2017 Jun 24.
    Ege University, Faculty of Medicine, Department of Pathology, Izmir, Turkey.
    HER2 amplification has been demonstrated in 15-25% of invasive breast carcinomas and can be assessed using immunohistochemical and in situ hybridization methods. Here, we compared the accuracy of dual SISH to manual FISH in HER2 (2+) breast carcinoma and evaluated the feasibility of dual SISH method in routine practice. Sixty HER2 (2+) consecutive tumor samples diagnosed between January 2009 and February 2013 were selected. Read More

    IMP3 contributes to poor prognosis of patients with metaplastic breast carcinoma: A clinicopathological study.
    Ann Diagn Pathol 2017 Dec 26;31:30-35. Epub 2017 May 26.
    Department of Diagnostic Pathology, Nippon Medical School Hospital, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan; Department of Integrated Diagnostic Pathology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
    Metaplastic breast carcinoma (MBC) is a rare type of tumor with heterogenous histological patterns. We investigated the immunohistochemical expression of IMP3, an oncofetal protein, in 31 MBC patients in association with histological subtypes and clinical outcomes. The cohort consisted of spindle cell carcinoma (SPC) (n=11), squamous cell carcinoma (SCC) (n=14), matrix-producing carcinoma (MPC) (n=4), carcinoma with osteocartilaginous elements (COC) (n=1), and low grade adenosquamous cell carcinoma (ASC) (n=1). Read More

    Lymphocytic thrombophilic arteritis: A distinct inflammatory type I interferon and C5b-9 mediated subcutaneous endovasculitis.
    Ann Diagn Pathol 2017 Dec 15;31:23-29. Epub 2017 Jun 15.
    Department of Pathology, Weill Cornell Medicine, NY, New York, United States.
    Background: Lymphocytic thrombophilic arteritis is a recently recognized subcuticular larger vessel vasculitis characterized by striking vascular luminal thrombosis.

    Methods: The clinical features, histopathology and phenotypic profile of ten patients with lymphocytic thrombophilic arteritis were explored in an attempt to better define the entity from a clinical and pathophysiologic perspective.

    Results: The patients were all female (mean age of 43) presenting with generally asymptomatic lower and upper extremity hyperpigmented macules. Read More

    Phenotypic alterations in breast cancer associated with neoadjuvant chemotherapy: A comparison with baseline rates of change.
    Ann Diagn Pathol 2017 Dec 16;31:14-19. Epub 2017 Jun 16.
    Department of Pathology, University of California San Diego, San Diego, CA, United States. Electronic address:
    Several studies have documented phenotypic alterations in breast cancer associated with neoadjuvant chemotherapy [NACT], but many of these studies are limited by the fact that they did not account for the baseline rate of expected phenotypic change between biopsies and resections in the absence of NACT. Herein, we assess whether the NACT-associated rate of phenotypic change is significantly different than would be expected in a control population of patients that did not receive NACT. From a pathologic database, we documented the estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2/neu) phenotypes of consecutive invasive breast carcinomas (n=826), as well as the subset in which at least one of these tests was assessed in both the biopsy and resection (n=340). Read More

    Beta-catenin and p53 expression in topographic compartments of colorectal cancer and its prognostic value following surgery.
    Ann Diagn Pathol 2017 Dec 27;31:1-8. Epub 2017 May 27.
    UGC Provincial de Anatomía Patológica, Hospital Universitario "Virgen de la Victoria", Campus de Teatinos, S/N, 29010 Málaga, Spain.
    Colorectal cancer (CRC) is the third most prevalent neoplasm worldwide and the fourth cause of cancer-related death. From Vogelstein's initial model, new molecular knowledge has been incorporated which includes an elevated number of genetic mutations, many of them located in the Wnt pathway, which affect its principle effector: β-catenin. Additionally, it is necessary to keep the heterogeneity of CRCs in mind, both in terms of morphology and biology. Read More

    Expression of dog1 in low-grade fibromyxoid sarcoma: A study of 19 cases and review of the literature.
    Ann Diagn Pathol 2017 Oct 11;30:8-11. Epub 2017 May 11.
    UGC Pathology, Hu Virgen Macarena, Seville, Spain. Electronic address:
    DOG1 is a highly-sensitive marker often included in the immunohistochemical panel for the diagnosis of gastrointestinal stromal tumors (GISTs). Recent research has shown that DOG1 may also be expressed by low-grade fibromyxoid sarcomas (LGFMSs); this may give rise to diagnostic error when the sarcoma is located in the abdominal cavity. This paper reports on immnohistochemical expression of DOG1 in 19 LGFMSs using two different monoclonal antibodies: K9 (Leica, Novocastra Laboratories, Newcastle upon Tyne, UK) and SP31 (Thermo Scientific, Freemont, USA). Read More

    CD30+ T cell enriched primary cutaneous CD4+ small/medium sized pleomorphic T cell lymphoma: A distinct variant of indolent CD4+ T cell lymphoproliferative disease.
    Ann Diagn Pathol 2017 Oct 27;30:52-58. Epub 2017 Apr 27.
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.
    Primary cutaneous CD4+ small/medium sized pleomorphic T-cell lymphoma (SMPTCL) is unique among the peripheral T-cell lymphomas because of its indolent nature, typically presenting as a solitary nodule or plaque in the head and neck area of middle-aged and older adults. Recent studies have suggested a follicular helper cell origin for these lesions.

    Materials And Methods: A retrospective review was conducted on all cases of SMPTCL diagnosed between 2008 and 2017. Read More

    Cyclin D1 is significantly associated with stage of tumor and predicts poor survival in endometrial carcinoma patients.
    Ann Diagn Pathol 2017 Oct 20;30:47-51. Epub 2017 Apr 20.
    Departments of Pathology, Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:
    Cyclin D1 overexpression has been described to have oncogenic role and association with diagnosis, prognosis and survival in various tumors. This study will describe the immunohistochemical phenotype of cyclin D1, and investigate the correlation between these patterns of expression and clinicopathological parameters of endometrial carcinomas, to conclude the clinical relevance of cyclin D1 expression in the evolution of endometrial neoplasms. This study employed 101 endometrial tissue samples which include 71 endometrial carcinomas and thirty normal and benign endometrium cases. Read More

    Dedifferentiated chondrosarcoma of the larynx: Radiological, gross, microscopic and clinical features.
    Ann Diagn Pathol 2017 Oct 16;30:42-46. Epub 2017 May 16.
    Department of Otolaryngology, Emory University Hospital, Atlanta, GA 30308, USA.
    Laryngeal chondrosarcoma is an uncommon malignancy with a predilection for the cricoid cartilage of adult male patients. Although rare, identification of aggressive chondrosarcoma variants, such as dedifferentiated chondrosarcoma (DDCS) may influence preoperative patient counseling, definitive surgical management, potential implementation of post-operative adjuvant therapy and prognosis. Herein we describe clinical and imaging features of laryngeal DDCS, the unique perspective of fresh and formalin fixed macroscopic examination, a spectrum of histopathologic findings, and detail the full course of the patient's disease. Read More

    Establishing Fascin over-expression as a strategic regulator of neoplastic aggression and lymph node metastasis in oral squamous cell carcinoma tumor microenvironment.
    Ann Diagn Pathol 2017 Oct 26;30:36-41. Epub 2017 May 26.
    Scientist-D, Institute of Life Sciences, Bhubaneswar 751023, India.
    Introduction: Oral squamous cell carcinoma (OSCC) has an aggressive behaviour with high incidence of nodal metastasis, even in the early stages, leading to poor prognosis. For progression and metastasis of cancers, the dominant element considered is cell motility. Fascin, an actin-binding protein has emerged as a protein of general importance for a diverse set of cell protrusions with functions in cell adhesion, cell interactions, and cell migration. Read More

    Utility of different immunostains for diagnosis of metastatic breast carcinomas in both surgical and cytological specimens.
    Ann Diagn Pathol 2017 Oct 17;30:21-27. Epub 2017 May 17.
    Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH, United States. Electronic address:
    Objective: A panel of immunostains is usually performed to confirm a metastatic carcinoma origin. GATA3 is a transcription factor and has been proven to be a useful marker for breast carcinoma. Other immunostains including mammaglobin (MGB), gross cystic disease fluid protein 15 (GCDFP-15), estrogen receptor (ER) and progesterone receptor (PR) are also used in diagnosing metastatic breast cancer. Read More

    Chronic inflammation in refractory hippocampal sclerosis-related temporal lobe epilepsy.
    Ann Diagn Pathol 2017 Oct 16;30:12-16. Epub 2017 May 16.
    Cleveland Clinic Department of Anatomic Pathology, Cleveland Clinic Lerner College of Medicine, USA. Electronic address:
    Emerging evidence suggests chronic inflammation may play a role in hippocampal sclerosis-associated temporal lobe epilepsy. We sought to systematically evaluate for its presence in a group of 315 patients who underwent surgery for medically-refractory epilepsy and who had hippocampal sclerosis. Upon histologic review of hematoxylin and eosin stained tissue sections, 95 (41%) cases demonstrated the presence of lymphocytes within the perivascular region and diffusely within the brain parenchyma. Read More

    Expression of pRb, Ki67 and HER 2/neu in gastric carcinomas: Relation to different histopathological grades and stages.
    Ann Diagn Pathol 2017 Oct 12;30:1-7. Epub 2017 May 12.
    Pathology Department, Faculty of Medicine, Mansoura University, Egypt.
    Gastric carcinoma is one of the aggressive malignancies with poor prognosis. The expression of pRb, Ki67, Her-2 in relation to tumor grade and stage in gastric carcinoma still needs more exploration. This study was performed aiming to study the immunohistochemical expression of altered retinoblastoma encoding protein (pRb), Ki67 and Her-2 in gastric carcinoma and to investigate their clinical and pathological significance. Read More

    Hamartia in hippocampal sclerosis-associated mesial temporal lobe epilepsy.
    Ann Diagn Pathol 2017 Sep 6. Epub 2017 Sep 6.
    Cleveland Clinic Department of Anatomic Pathology, Cleveland, OH, USA. Electronic address:
    Hamartia are small collections of rounded glioneuronal cells that are thought to be due to aberrant cell migration. Their presence has been recognized in association with mesial temporal lobe epilepsy; their prevalence among cases of hippocampal sclerosis (HS) and any potential association with patient demographics and outcomes is unknown. This study examines hamartia in a series of 292 patients with pathologically confirmed HS. Read More

    Application of a time-resolved fluoroimmunoassay for detection of p16INK4a in cervix.
    Ann Diagn Pathol 2017 Aug 12;29:7-10. Epub 2017 Apr 12.
    The First People's Hospital of Jingmen, Jingmen, 448000, People's Republic of China. Electronic address:
    Objective: To establish a time-resolved fluoroimmunoassay (TRFIA) method to detect p16INK4a.

    Methods: 119 cases of exfoliative cells following Thinprep cytologic test (TCT) test were selected for TRFIA and biopsy tissues of these patients according to TCT results were collected for immunohistochemical (IHC) staining.

    Results: There were 40 cases with cervicitis, 16 cases of cervical intraepithelial neoplasia grade 1 (CIN1), 15 cases of CIN2, 26 cases of CIN3, and 22 cases of squamous cell carcinoma (SCC). Read More

    AMPK expression patterns are significantly associated with poor prognosis in breast cancer patients.
    Ann Diagn Pathol 2017 Aug 16;29:62-67. Epub 2017 May 16.
    Department of Pathology, Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:
    Many investigators have examined the functions of AMP-activated protein kinase (AMPK) in cancer biology and its anti-neoplastic features in cancer models. The goal of this research is to assess the association of the immunohistochemical expression of AMPK in human mammary tumours with the clinical data of breast cancer patients. 449 cases of previously diagnosed breast cancer, and 27 tissue samples of fibroadenomas and normal breast were utilized for detection of AMPK expression using tissue microarrays and immunohistochemistry. Read More

    Pituicytoma: Review of commonalities and distinguishing features among TTF-1 positive tumors of the central nervous system.
    Ann Diagn Pathol 2017 Aug 11;29:57-61. Epub 2017 May 11.
    Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Suite 2400, Alton Road 4300, Miami Beach, 33140, FL,USA.
    Pituicytoma is a rare low-grade glial neoplasm that originates in the distribution of the neurohypophysis, including the posterior pituitary lobe and infundibular stalk. The tumor cells resemble pituicytes, which are specialized glial cells of the neurohypophysis. Pituicytoma can be misdiagnosed pre-operatively as a pituitary adenoma due to overlapping clinical and neuroimaging features between these two entities. Read More

    Anisometric cell lipoma: Insight from a case series and review of the literature on adipocytic neoplasms in survivors of retinoblastoma suggest a role for RB1 loss and possible relationship to fat-predominant ("fat-only") spindle cell lipoma.
    Ann Diagn Pathol 2017 Aug 29;29:52-56. Epub 2017 Apr 29.
    Institute of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, University Hospital of Erlangen, Erlangen, Germany. Electronic address:
    The term "anisometric cell lipoma" (ACL) has been proposed recently by Evans for a lipoma variant characterized by striking variation in size and shape of adipocytes but little or no cytological atypia. One patient with multiple ACL had a history of retinoblastoma. The current study analyzed six patients with ACL (4 males and two females aged 34 to 87years; median, 58); all seen in consultation. Read More

    Accuracy and interobserver agreement of retroareolar frozen sections in nipple-sparing mastectomies.
    Ann Diagn Pathol 2017 Aug 3;29:46-51. Epub 2017 May 3.
    Department of Pathology and Laboratories, Fundación Santa Fe de Bogotá, Bogotá D.C., Colombia; School of Medicine, Universidad de los Andes, Bogotá D.C., Colombia. Electronic address:
    In the last decades, surgical treatment of breast cancer has enormously changed. As a result, nipple-sparing mastectomy (NSM) has evolved as an oncologically safe and cosmetic approach. NSM includes a subareolar frozen section to evaluate malignancy. Read More

    Ultrastructural examination of skin biopsies may assist in diagnosing mitochondrial cytopathy when muscle biopsies yield negative results.
    Ann Diagn Pathol 2017 Aug 28;29:41-45. Epub 2017 Apr 28.
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA. Electronic address:
    Ultrastructural evaluation of skin biopsies has been utilized for diagnosis of mitochondrial disease. This study investigates how frequently skin biopsies reveal mitochondrial abnormalities, correlates skin and muscle biopsy findings, and describes clinical diagnoses rendered following the evaluation. A retrospective review of surgical pathology reports from 1990 to 2015 identified skin biopsies examined by electron microscopy for suspected metabolic disease. Read More

    Unusual locations of hydatid disease: A 10-year experience from a tertiary reference center in Western Turkey.
    Ann Diagn Pathol 2017 Aug 29;29:37-40. Epub 2017 Apr 29.
    Department of Pathology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Basin Sitesi, 35360 Karabaglar, Izmir, Turkey.
    Introduction: Hydatid disease is an endemic parasitic infection caused by Echinococcus granulosus mostly seen in the Mediterranean countries. The most affected organ is the liver, however hydatidosis can be found anywhere in the human body.

    Methods: The records of patients who were diagnosed with hydatid disease in our hospital from December 2005 to February 2016 were analyzed retrospectively. Read More

    Primary collision tumors of the kidney composed of oncocytoma and papillary renal cell carcinoma: A review.
    Ann Diagn Pathol 2017 Aug 2;29:32-36. Epub 2017 May 2.
    Departments of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, United States. Electronic address:
    Background: There are well known cases of hybrid tumors of chromophobe renal cell carcinoma (RCC) and oncocytoma in kidney, where both tumors have the same cell of origin - intercalated cell of the collecting duct. However, collision tumors composed of neoplasms originating from different cell lineages such as oncocytoma and papillary RCC are extremely rare. Herein, we made a collective literature review of reported cases of collision tumors composed of oncocytoma and papillary RCC, adding a case that we recently experienced. Read More

    Molecular pathology diagnosis of diffuse large B cell lymphoma using BIOMED-2 clonal gene rearrangements.
    Ann Diagn Pathol 2017 Aug 27;29:28-31. Epub 2017 Apr 27.
    Department of Molecular Biology, Ahar Branch, Islamic Azad University, Ahar, Iran. Electronic address:
    Background: Clonality testing for immunoglobulin gene rearrangement analysis could be implemented effectively as a useful technique for conventional diagnosis of lymphoma. The European Biomedicine and Health Concerted Action Project BMH4-CT98-3936 (BIOMED-2) have been suggested a gold standard method to clonality detection.

    Objectives: We tested empirically clonality rearrangements of IGH and incomplete IGH D-J, on formalin-fixed, paraffin embedded (FFPE) tissue of patients with diffuse large B cell lymphoma (DLBCL). Read More

    Evaluation of CD43 expression in non-hematopoietic malignancies.
    Ann Diagn Pathol 2017 Aug 26;29:23-27. Epub 2017 Apr 26.
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address:
    Objectives: CD43 is normally expressed only on the surface of leukocytes, and is considered a sensitive and specific marker for hematologic malignancies. As such, it may have diagnostic utility in confirming hematolymphoid lineage in cases that are negative for CD45. Aberrant CD43 expression has been described in non-hematopoietic tumors, although literature data on this topic is variable and sometimes contradictory. Read More

    Programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) expression in fumarate hydratase-deficient renal cell carcinoma.
    Ann Diagn Pathol 2017 Aug 24;29:17-22. Epub 2017 Apr 24.
    Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic. Electronic address:
    Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare and aggressive tumor affecting mostly younger patients. This is the first study to assess the expression of programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) in FH-RCC. Formalin-fixed paraffin-embedded samples from 13 FH-RCCs collected in an international multi-institutional study, were evaluated by immunohistochemistry (IHC) for PD-1/PD-L1 reactivity in tumor cells and tumor infiltrating lymphocytes (TILs). Read More

    Recent updates on grading and classification of neuroendocrine tumors.
    Ann Diagn Pathol 2017 Aug 13;29:11-16. Epub 2017 Apr 13.
    Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, United States. Electronic address:
    Neuroendocrine tumors (NETs) are originating from neuroendocrine cells in diffuse endocrine systems. NETs are diagnosed by characteristic histologic features and immunoprofiles. Recent 2010 WHO classification for gastroenteropancreatic NETs introduced grading system based on mitotic count and Ki-67 proliferation index. Read More

    A semi-quantitative World Health Organization grading scheme evaluating worst tumor differentiation predicts disease-free survival in oral squamous carcinoma patients.
    Ann Diagn Pathol 2017 Aug 8;29:1-6. Epub 2017 Apr 8.
    Department of Radiotherapy, Delhi State Cancer Institute, Delhi 110095, India.
    We investigated World Health Organization (WHO) grading and pattern of invasion based histological schemes as independent predictors of disease-free survival, in oral squamous carcinoma patients. Tumor resection slides of eighty-seven oral squamous carcinoma patients [pTNM: I&II/III&IV-32/55] were evaluated. Besides examining various patterns of invasion, invasive front grade, predominant and worst (highest) WHO grade were recorded. Read More

    Dedifferentiated chondrosarcoma of bone with prominent rhabdoid component.
    Ann Diagn Pathol 2017 Jun 24;28:7-11. Epub 2016 Nov 24.
    Department of Pathology, Hospital for Special Surgery, New York, NY, United States. Electronic address:
    Dedifferentiated chondrosarcomas (DDCS) are rare lesions, defined as tumors having a low-grade chondrosarcomatous component with an abrupt transition to a high-grade sarcoma. Although "malignant fibrous histiocytoma" (undifferentiated pleomorphic sarcoma) is the most common high grade saromatous component, many different types of sarcoma have been described. We present a case of dedifferentiated chondrosarcoma with rhabdomyosarcomatous differentiation harboring a prominent rhabdoid tumor component. Read More

    Low-grade fibromyxoid sarcoma: Clinical, morphologic and genetic features.
    Ann Diagn Pathol 2017 Jun 5;28:60-67. Epub 2017 Apr 5.
    Sarcoma Unit, Royal Marsden Hospital, London, UK. Electronic address:
    Low-grade fibromyxoid sarcoma (LGFMS) is a bland spindle cell neoplasm that typically arises in the deep soft tissues of the proximal extremities or trunk of young adults. The majority of LGFMS are characterized by a recurrent (7;16)(q34;p11) translocation, resulting in the FUS-CREB3L2 fusion gene, which generates a chimeric protein with transcriptional regulatory activity. Small numbers harbor a FUS-CREB3L1 fusion resulting from t(11;16)(p11;p11), whilst rare cases harbor the EWSR1-CREB3L1 fusion. Read More

    Upregulation of inhibitory signaling receptor programmed death marker-1 (PD-1) in disease evolution from cutaneous lymphoid dyscrasias to mycosis fungoides and Sezary's syndrome.
    Ann Diagn Pathol 2017 Jun 10;28:54-59. Epub 2017 Feb 10.
    Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:
    Background: Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. Read More

    Prognostic impact of EGFR and cytokeratin 5/6 immunohistochemical expression in triple-negative breast cancer.
    Ann Diagn Pathol 2017 Jun 4;28:43-53. Epub 2017 Feb 4.
    General Surgery Department, Faculty of Medicine, Zagazig University, Egypt.
    Triple-negative breast cancer (TNBC) has an aggressive behavior and limited therapeutic options due to lack of targeted therapy. We aimed in this study to assess the immunohistochemical expression of EGFR and cytokeratin 5/6 and their ability to predict survival and response to neoadjuvant chemotherapy (NAC) among triple-negative breast cancer patients. Thirty-five cases with TNBC were studied by immunohistochemistry for EGFR and CK5/6 expression. Read More

    Lymphoid malignancy-associated hemophagocytic lymphohistiocytosis: Search for the hidden source.
    Ann Diagn Pathol 2017 Jun 20;28:37-42. Epub 2017 Feb 20.
    Department of Hematology and Oncology, Temple University Hospital, 3401 N Broad Street, Philadelphia, PA 19140, USA. Electronic address:
    Secondary hemophagocytic lymphohistiocytosis (HLH) is an uncommon, but life-threatening syndrome of highly stimulated and ineffective immune dysregulation. It is not a disease entity by itself and the current diagnosis of secondary (acquired) HLH is based on constellation of nonspecific clinical and laboratory parameters indicative of overactive immune response. The presenting symptoms are often nonspecific and could potentially be missed, leading to a fatal outcome. Read More

    The correlation of the standard 5 probe FISH assay with melanocytic tumors of uncertain malignant potential.
    Ann Diagn Pathol 2017 Jun 10;28:30-36. Epub 2016 Nov 10.
    Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address:
    Background: FISH has recently emerged as a technique to better assess the malignant potential of histologically ambiguous melanocytic lesions. However, the usefulness of FISH has not been conclusively established. The purpose of this study was to further explore the diagnostic value of FISH in distinguishing the borderline melanocytic tumor (BMT) from melanoma. Read More

    Diagnostic pathology of Alzheimer's disease from routine microscopy to immunohistochemistry and experimental correlations.
    Ann Diagn Pathol 2017 Jun 13;28:24-29. Epub 2017 Feb 13.
    GNOME Diagnostics, Powell, OH, United States.
    The absence of any histologic correlate for Alzheimer's disease despite its commonness and severe clinical sequelae may offers clues to its etiology. Recent evidence strongly suggests that the central event of this disease is the hyperphosphorylation of neuronal tau protein and not the beta amyloid precipitates. In each case, essential and soluble neuronal proteins derivatives form insoluble aggregates that can readily be detected by immunohistochemistry using antibodies specific for the misfolded proteins. Read More

    EWSR1 rearrangement is present in a subset of myoepithelial tumors of salivary glands with variable morphology and does not correlate with clinical behavior.
    Ann Diagn Pathol 2017 Jun 13;28:19-23. Epub 2017 Feb 13.
    Department of Pathology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China; Department of Pathology, Jinling Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address:
    To investigate that whether myoepithelial tumors of salivary glands (MTs) with EWSR1 rearrangement display distinctive morphological characteristics and whether EWSR1 detection aids to distinguish malignant myoepithelial tumors (MMTs) from benign myoepithelial tumors (BMTs) of salivary glands. We examined 37 cases of MTs, including 24 BMTs, 13 MMTs, by histological, immunohistochemical, and molecular analysis. All of 37 cases were immunoreactive for CKpan, and at least one myoepithelial marker. Read More

    Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor.
    Ann Diagn Pathol 2017 Jun 9;28:12-18. Epub 2017 Feb 9.
    Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; Bioptical Laboratory, Pilsen, Czech Republic. Electronic address:
    Lesions affecting anogenital mammary-like glands (AGMLG) are histopathologically very similar to those seen in the breast but whether this morphological similarity is also reflected at the genetic level is unknown. To compare the underlying molecular mechanisms in lesions of AGMLG and their mammary counterparts, we analyzed the mutational profile of 16 anogenital neoplasms including 5 hidradenomas papilliferum (HP), 1 lesion with features of HP and fibroadenoma (FA), 7 FA, 3 phyllodes tumors (PhT)) and 18 analogous breast lesions (6 intraductal papillomas (IDP), 9 FA, and 3 PhT) by high-coverage next generation sequencing (NGS) using a panel comprising 50 cancer-related genes. Additionally, all cases were analyzed for the presence of a mutation in the MED12 gene. Read More

    Effectiveness and safety of two 18-gauge needle types on native and allograft renal biopsies.
    Ann Diagn Pathol 2017 Jun 5;28:1-6. Epub 2017 Feb 5.
    Department of Pathology, Laboratory Medicine, University of Toronto, Canada. Electronic address:
    Percutaneous biopsy is a key diagnostic tool for both native and allograft kidney diseases. Adequacy criteria vary, but at a minimum, a biopsy should allow the pathologist to reach a diagnosis and provide prognostic information such as the degree of interstitial fibrosis and tubular atrophy (IF/TA) and percentage of glomerulosclerosis. Whereas most studies use glomerular counts as a surrogate for biopsy adequacy, the amount and preservation of tubulointerstitium is equally important, considering IF/TA is a major prognostic parameter for most medical renal diseases. Read More

    Contribution of MAML1 in esophageal squamous cell carcinoma tumorigenesis.
    Ann Diagn Pathol 2017 Apr 1;27:79-82. Epub 2017 Feb 1.
    Department of Biology, Damghan branch, Islamic Azad University, Damghan, Iran.. Electronic address:
    Background: Notch signaling pathway is involved in different cellular and developmental processes including cell proliferation, differentiation and apoptosis. Mastermind like1 (MAML1) is a critical key transcription coactivator of this pathway. In this study, we aimed to examine MAML1 protein expression in esophageal squamous cell carcinoma (ESCC) and reveal its association with clinicopathological variables of the patients. Read More

    Whorling cellular perineurioma: A previously undescribed variant closely mimicking monophasic fibrous synovial sarcoma.
    Ann Diagn Pathol 2017 Apr 2;27:74-78. Epub 2017 Feb 2.
    Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 80, 304 60 Pilsen, Czech Republic.
    The authors present a distinctive perineurioma (PN) variant which morphologically strongly resembles monophasic fibrous synovial sarcoma (MSS). The patients were 3 males and 1 female. The age ranged from 15 to 61years (mean: 44years). Read More

    Macrocystic ductal adenocarcinoma of prostate: A rare gross appearance of prostate cancer.
    Ann Diagn Pathol 2017 Apr 29;27:7-13. Epub 2016 Dec 29.
    Department of Human Pathology, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8509, Japan. Electronic address:
    Macroscopic cyst-formation by prostatic adenocarcinoma, herein referred to as macrocystic prostatic adenocarcinoma (MPA), is extremely rare. To date, no studies of prostate cancer performed based on gross cystic appearance have been reported. MPA can include various diseases, one of which is cystadenocarcinoma. Read More

    Retroperitoneal lymphangioleiomyoma with lymph node involvement: A pathologic-radiologic correlation of a rare form of myomelanocytic tumor.
    Ann Diagn Pathol 2017 Apr 1;27:69-73. Epub 2017 Feb 1.
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:
    Lymphangioleiomyomatosis (LAM) is a rare and slowly progressive disorder that usually arises in the lung, affects exclusively women in their childbearing years, and typically presents with progressive dyspnea on exertion and pneumothorax. Infrequently, extra-pulmonary LAM can occur in the retroperitoneum, uterine wall, mediastinum and intraperitoneal lymph nodes. Histologically, LAM is characterized by a proliferation of perivascular epithelioid cells (PEC) that express markers for both melanocytes and smooth muscle cells. Read More

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