1,526 results match your criteria Annals of Diagnostic Pathology [Journal]


Reproducible evaluation of tumor-infiltrating lymphocytes (TILs) using the recommendations of International TILs Working Group 2014.

Ann Diagn Pathol 2018 May 31;35:77-79. Epub 2018 May 31.

Department of Pathology, University of Texas Health Science Center at Houston, 6431 Fannin St, Houston, TX 77030, United States. Electronic address:

Tumor infiltrating lymphocytes (TILs) in breast cancer play an important role in predicting the outcome of breast cancer. The goal of our current study is to investigate the consistency and reproducibility of the recommendations published by the International TILs Working Group 2014 among pathology trainees and pathologists. Hematoxylin & Eosin (H&E) slides from 129 breast cancer cases (one slide each) from 2009 to 2014 were evaluated. Read More

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WITHDRAWN: Fine needle aspiration cytology: A diagnostic tool in evaluation of lymphadenopathy in pediatric age.

Ann Diagn Pathol 2017 Dec 19. Epub 2017 Dec 19.

Department of Pathology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune 411018, India.

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December 2017

Evaluation of cMET aberration by immunohistochemistry and fluorescence in situ hybridization (FISH) in triple negative breast cancers.

Ann Diagn Pathol 2018 May 3;35:69-76. Epub 2018 May 3.

Department of Pathology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA; Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA. Electronic address:

Purpose: To evaluate the incidence of cMET proto-oncogene aberration in a cohort of triple negative breast cancers using immunohistochemistry and fluorescence in situ hybridization (FISH) methods and correlated with patient outcome.

Patients And Methods: One hundred and six female patients with diagnosis of triple negative invasive breast carcinoma at The University of Texas-M D Anderson Cancer Center from 1983 to 2009 were included in the study. Expression of cMET was assessed by IHC using rabbit monoclonal anti-total cMET antibody (SP44 from Ventana). Read More

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May 2018
3 Reads

Should we excise? Are there any clinical or histologic features that predict upgrade in papillomas, incidental or non-incidental?

Ann Diagn Pathol 2018 May 11;35:62-68. Epub 2018 May 11.

Department of Pathology, Division of Anatomic Pathology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, United States. Electronic address:

The clinical decision to excise intraductal papilloma (IDP) without atypia diagnosed on biopsy remains controversial. We sought to establish clinical and histologic predictors (if any) which may predict upgrade in IDP. 296 biopsies (in 278 women) with histologic diagnosis of IDP without atypia were retrospectively identified and placed into Incidental (no corresponding imaging correlate), or Non-incidental (positive imaging correlate) groups. Read More

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Prognostic impact of tumor-stroma ratio in oral squamous cell carcinoma - A pilot study.

Ann Diagn Pathol 2018 May 17;35:56-61. Epub 2018 May 17.

Department of Oral and Maxillofacial Pathology, SDM College of Dental Sciences and Hospital, Dharwad 580 009, Karnataka, India.

Background: Several prognostic indicators have been used for many decades in an attempt to predict clinical behaviour of Oral Squamous Cell Carcinoma (OSCC). The prognostic value of TSR is yet to be explored in OSCC. Hence, the aim of the present study was to evaluate the prognostic value of TSR in OSCC patients. Read More

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Fibro-osseous pseudotumor of digits - Expanding the spectrum of clonal transient neoplasms harboring USP6 rearrangement.

Ann Diagn Pathol 2018 May 12;35:53-55. Epub 2018 May 12.

Department of Pathology (Pathologie-DNA), Diakonessenhuis Utrecht, Utrecht, The Netherlands.

Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH). Read More

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May 2018
1 Read

Analytical and clinical performance of progesterone receptor antibodies in breast cancer.

Ann Diagn Pathol 2018 Feb 27;35:21-26. Epub 2018 Feb 27.

Ventana Medical Systems, Inc., Tucson, AZ, USA. Electronic address:

Objective: Comparison of analytical and immunohistochemical performance of progesterone receptor (PR) antibodies with correlation to recurrence of invasive breast cancer treated with endocrine therapy.

Methods: The binding-affinity kinetics of PR clones 1E2, 1A6, 16 and 636 were compared using synthetic peptides derived from identified epitopes on a Biacore T200. A cohort of 351 cases (Hormone Receptor (HR)+/HER2-) were stained for PR expression with immunohistochemistry (IHC) and scored according to ASCO/CAP criteria. Read More

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February 2018
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Immunohistochemical expression of glypican-3 in adrenocortical carcinoma: A potential cause of diagnostic pitfalls.

Ann Diagn Pathol 2018 May 3. Epub 2018 May 3.

Department of Human Pathology, University of Messina, Italy. Electronic address:

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Serrated epithelial colorectal polyps (hyperplastic polyps, sessile serrated adenomas) with perineurial stroma: Clinicopathological and molecular analysis of a new series.

Ann Diagn Pathol 2018 May 4;35:48-52. Epub 2018 May 4.

Institute of Pathology, University Hospital, Erlangen, Germany. Electronic address:

Serrated colorectal fibroblastic polyps (FPs) are rare benign mucosal lesions composed of serrated epithelial crypts separated and distorted by intimately associated bland spindle cell proliferations with perineurial-like phenotype. We herein describe 21 new FPs affecting 10 females and 9 males aged 45 to 80 yrs. (mean, 62 yrs). Read More

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Expression of p27 and c-Myc by immunohistochemistry in breast ductal cancers in African American women.

Ann Diagn Pathol 2018 Jun 5;34:170-174. Epub 2018 Apr 5.

Department of Pathology, Howard University College of Medicine, Washington, DC, United States.

Objectives: Proteins p27 and c-Myc are both key players in the cell cycle. While p27, a tumor suppressor, inhibits progression from G1 to S phase, c-Myc, a proto-oncogene, plays a key role in cell cycle regulation and apoptosis. The objective of our study was to determine the association between expression of c-Myc and the loss of p27 by immunohistochemistry (IHC) in the four major subtypes of breast cancer (BC) (Luminal A, Luminal B, HER2, and Triple Negative) and with other clinicopathological factors in a population of 202 African-American (AA) women. Read More

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Solid pseudopapillary neoplasm (SPN) of the testis: Comprehensive mutational analysis of 6 testicular and 8 pancreatic SPNs.

Ann Diagn Pathol 2018 Apr 20;35:42-47. Epub 2018 Apr 20.

Department of Pathology, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic.

Background: Recently, we came with the theory of a possible relationship between a group of testicular and pancreatic tumors. We used one case of a pancreatic analogue solid pseudopapillary neoplasm of the testis composed partially of areas reminiscent of solid pseudopapillary neoplasm (SPN) of the pancreas and partially of structures identical to primary signet ring stromal tumor of the testis (PSRSTT) as a connecting link between these two entities. After demonstrating that PSRSTT and pancreatic analogue SPN of the testis share the same immunoprofile and genetic features characteristic for pancreatic SPN, we came to the conclusion that pancreatic analogue SPN of the testis and PSRSTT represent a morphological spectrum of a single entity and that both are related to the pancreatic SPN. Read More

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April 2018
5 Reads

Multifocal occurrence of extra-abdominal desmoid type fibromatosis - A rare manifestation. A clinicopathological study of 6 sporadic cases and 1 hereditary case.

Ann Diagn Pathol 2018 Apr 21;35:38-41. Epub 2018 Apr 21.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Desmoid-type fibromatosis, also called desmoid tumor, is a locally aggressive myofibroblastic neoplasm that usually arises in deep soft tissue with significant potential for local recurrence. It displays an unpredictable clinical course. β-Catenin, the genetic key player of desmoid tumors shows nuclear accumulation due to mutations that prevent its degradation leading to activation of Wnt signaling and myofibroblastic cell proliferation. Read More

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Submandibular gland pleomorphic adenoma: Histopathological capsular characteristics and correlation with the surgical outcome.

Ann Diagn Pathol 2018 Jun 18;34:166-169. Epub 2018 Apr 18.

Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Pleomorphic adenoma (PA) of the submandibular gland is known to have a very low recurrence rate. The aim of this study was to investigate the histopathological and capsular characteristics of submandibular gland PA, looking for any differences between submandibular PA and the reported data for PA of the parotid gland as possible explanation for its low recurrence rate. We reviewed 72 submandibular gland PAs resected at our center between 2000 and 2016. Read More

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Overexpression of Lox in triple-negative breast cancer.

Ann Diagn Pathol 2018 Jun 27;34:98-102. Epub 2018 Mar 27.

Department of Pathology and Molecularpathology, University Hospital Zurich, 8010 Zurich, Switzerland. Electronic address:

Background: Triple negative breast cancer (TNBC) accounts for approximately 15% of breast cancers. It is associated with a poor prognosis and typically earlier onset of metastasis in comparison with other breast cancer subtypes. Since TNBC lacks the expression of estrogen and progesterone receptors and Her2 status is also negative, there is currently no target that can be used for systemic therapy. Read More

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June 2018
3 Reads

A rapid triage protocol to optimize cold ischemic time for breast resection specimens.

Ann Diagn Pathol 2018 Jun 6;34:94-97. Epub 2018 Mar 6.

Medical College of Wisconsin, Department of Pathology, 9200 W. Wisconsin Ave., Lab Bldg., Lower Level, L53, Milwaukee, WI 53226, USA. Electronic address:

Prolonged time from specimen excision to adequate formalin exposure, or cold ischemic time (CIT), negatively impacts estrogen receptor (ER), progesterone receptor (PR) and HER-2 biomarker studies routinely performed on breast specimens. Current guidelines recommend CIT of ≤1 h. Since formalin penetrates resections slowly, optimal fixation requires incision. Read More

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June 2018
1 Read

Loss of PD-L1 (SP-142) expression characterizes renal vein tumor thrombus microenvironment in clear cell renal cell carcinoma.

Ann Diagn Pathol 2018 Jun 24;34:89-93. Epub 2018 Mar 24.

Service of Urology, University Hospital of Getafe, Getafe, Madrid, Spain; Clinical Department, European University of Madrid, Laureate Universities, Madrid, Spain.

Immunotherapy is a promising tool in the treatment of patients with advancer renal cancer, in particular the blockage of immune checkpoint inhibitors. Clear cell renal cell carcinoma is an example of heterogeneous neoplasm and this particular characteristic is responsible of many therapeutic failures so far. Since variations in the local microenvironment across a tumor may conditionate the effect of this new therapy, a deeper knowledge of this issue seems advisable for any treatment success. Read More

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June 2018
1 Read

Fine needle aspiration of alveolar soft part sarcoma in a child: Cytomorphological clues for the surgical pathologist.

Ann Diagn Pathol 2018 Jun 23;34:85-88. Epub 2018 Feb 23.

Department of Pathology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, United States; Division of Pediatric Pathology, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue MS#701, Milwaukee, WI 53226, United States. Electronic address:

Alveolar soft part sarcoma (ASPS) is a rare soft tissue neoplasm generally affecting adolescents and young adults. Its unique histologic and ultrastructural features have been well-described; however, the cytopathological features of ASPS are less well-characterized, and recognition of this entity's features on cytologic preparations can ensure that the specimen adequacy and appropriate/rapid tissue allocation for additional testing. Herein we report a FNA case of ASPS with emphasis on cytomorphologic characteristics. Read More

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June 2018
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Pathology resident perspectives about early autopsy experiences.

Ann Diagn Pathol 2018 Jun 14;34:82-84. Epub 2018 Mar 14.

Department of Anatomic Pathology, L25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:

The performance of autopsies remains an integral part of residency training in Anatomic Pathology. A number of medical schools no longer require an autopsy experience; therefore, a subset of pathology residents has never seen an autopsy performed prior to commencement of residency training. Although much as been written regarding student's perspectives on their medical school anatomy experiences, practically nothing has been written about resident perspectives on the autopsy experience. Read More

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June 2018
3 Reads

Analysis of EML4-ALK rearrangement in non-small cell lung cancer in Argentina.

Ann Diagn Pathol 2018 Jun 26;34:77-81. Epub 2018 Feb 26.

Argentine Association of Clinical Oncology (AAOC), Buenos Aires, Argentina.

Introduction: Identification of EML4-ALK rearrangement by FISH test has become standard in advanced NSCLC patients. There is limited information about the prevalence and clinical characteristics of ALK translocation in Latin America. The aim of our study was to evaluate this lung cancer subtype features in Argentinian patients and the factibility of FISH test with different methods used for obtaining tissue samples. Read More

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June 2018
1 Read

MCM-2 expression differentiates potentially malignant verrucous lesions from oral carcinomas.

Ann Diagn Pathol 2018 Jun 13;34:72-76. Epub 2018 Mar 13.

Department of Oral and Maxillofacial Pathology, SDM College of Dental Sciences and Hospital, Dharwad 580 009, Karnataka, India.

Background: Mcm-2 is a biomarker belonging to Mcm family of proteins which has rarely been used in oral potentially malignant and malignant lesions of the verrucous type. The objective of this study is to assess the expression of Mcm-2 in Normal Oral Mucosa (NM), Verrucous Hyperplasia (VH), Verrucous Carcinoma (VC) and Oral Squamous Cell Carcinoma (OSCC) and compare it with the clinicopathological characteristics.

Methodology: A total of 70 formalin fixed paraffin embedded tissue samples (10 cases of Normal Mucosa NM- Group A, 10 cases of Verrucous Hyperplasia- VH without Dysplasia- Group B, 10 cases of Verrucous Hyperplasia- VH with Dysplasia- Group C, 20 cases of Verrucous Carcinoma VC-Group D, 20 cases of Oral Squamous Cell Carcinoma OSCC- Group E) were subjected to immunohistochemistry with Mcm-2 antibody. Read More

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June 2018
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Distribution of lymphoid neoplasms in Northwest China: Analysis of 3244 cases according to WHO classification in a single institution.

Ann Diagn Pathol 2018 Jun 12;34:60-65. Epub 2017 May 12.

Department of Hematology, People's Liberation Army Center of Hematologic Disorders, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:

To explore the distribution of lymphoid neoplasms in Northwest China, the clinical and pathological data of lymphoma patients from 2006 to 2014 were analyzed according to the WHO classification in Xijing Hospital. Of the 3244 cases, mature B-cell neoplasms occupied 60.7%, while mature T/NK-cell neoplasms and Hodgkin's lymphomas (HL) occupied 26. Read More

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June 2018
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Myositis ossificans - Another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst.

Ann Diagn Pathol 2018 Jun 12;34:56-59. Epub 2018 Jan 12.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Myositis ossificans is defined as a self-limiting pseudotumor composed of reactive hypercellular fibrous tissue and bone. USP6 rearrangements have been identified as a consistent genetic driving event in aneurysmal bone cyst and nodular fasciitis. It is therefore an integral part of the diagnostic workup when dealing with (myo)fibroblastic lesions of soft tissue and bone. Read More

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June 2018
1 Read

Overexpression of COX2 indicates poor survival in urothelial bladder cancer.

Ann Diagn Pathol 2018 Jun 31;34:50-55. Epub 2018 Jan 31.

National Institute of Pathology, Indian Council of Medical Research, New Delhi-110029, India. Electronic address:

Background: COX2 is a cyclo-oxygenase enzyme expressed in the tumor cells, inflammatory cells, stromal and non-epithelial cells. The study was conducted to evaluate the expression of COX2 in Urothelial carcinoma and find the association with progression and recurrence.

Methods: The expression of COX2 was evaluated by real-time PCR and immunohistochemistry. Read More

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June 2018
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Investigation of the relationship of Epstein-Barr virus with in situ hybridization in renal-cell carcinomas.

Ann Diagn Pathol 2018 Jun 20;34:45-49. Epub 2018 Feb 20.

Private Tinaztepe Hospital Microbiology Department, Izmir, Turkey.

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June 2018
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Detection of synchronous primary lung adenocarcinomas with genomic sequencing.

Ann Diagn Pathol 2018 Jun 11;34:42-44. Epub 2018 Jan 11.

Department of Pathology, University of Virginia Health System, P.O. Box 800214, 1215 Lee Street, Charlottesville, VA, United States. Electronic address:

In the setting of synchronous pulmonary carcinomas, distinguishing between a monoclonal process with intrapulmonary metastasis and two independent tumors has significant therapeutic and prognostic implications. We describe two cases in which molecular profiling was used to characterize synchronous, primary pulmonary tumors and guide clinical management. In both cases, the patients underwent surgical resection without adjuvant chemotherapy or radiation and remain free of disease. Read More

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June 2018
1 Read

Importin-β and exportin-5 are indicators of acute viral infection: Correlation of their detection with commercially available detection kits.

Ann Diagn Pathol 2018 Jun 10;34:36-41. Epub 2018 Jan 10.

Evandro Chagas National Institute of Infectious Diseases, and Laboratory of Interdisciplinary Medical Research (LIPMED), IOC, Rio de Janeiro, Brazil.

This work focused on immunohistochemistry markers of acute viral infections. Viral infected cells were detected by in situ based methods (reovirus, rabies virus) or cytologic changes (human papillomavirus, molloscum contagiosum virus, herpes simplex virus). Two proteins involved in nuclear trafficking, importin-β and exportin-5, were detected in the infected cells for each virus and not in the control tissues. Read More

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June 2018
8 Reads

Variation in nuclear size and PD-L2 positivity correlate with aggressive chromophobe renal cell carcinoma.

Ann Diagn Pathol 2018 Jun 10;34:31-35. Epub 2018 Jan 10.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address:

Chromophobe renal cell carcinoma (CRCC) is not amenable to International Society for Urologic Pathology-endorsed nucleolar grading. Novel grading approaches were proposed, but the rarity of adverse pathology hampers their discriminatory value. We investigate simple linear micrometer measurements and a proposed immunostain in CRCCs. Read More

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June 2018
4 Reads

High levels of intratumor heterogeneity characterize the expression of epithelial-mesenchymal transition markers in high-grade clear cell renal cell carcinoma.

Ann Diagn Pathol 2018 Jun 10;34:27-30. Epub 2018 Jan 10.

Biomarkers in Cancer Unit, Biocruces Research Institute, Barakaldo, Spain; Department of Pathology, Cruces University Hospital, University of the Basque Country (UPV/EHU), Barakaldo, Spain. Electronic address:

Immunohistochemistry is a basic routine in establishing the diagnosis of many tumors. However, immunomarkers are often irregularly distributed across different regions of the same tumor, alternating positive and negative areas without any apparent cause. Full identification of this type of intratumor heterogeneity is crucial for patients since the expression of many markers is linked to the prognosis and/or treatment of some tumors. Read More

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June 2018
1 Read

The knockdown of the mediator complex subunit MED30 suppresses the proliferation and migration of renal cell carcinoma cells.

Ann Diagn Pathol 2018 Jun 20;34:18-26. Epub 2017 Dec 20.

Clinic for Urology and Paediatric Urology, University Hospital of Bonn, Sigmund-Freud Str. 25, 53127 Bonn, Germany. Electronic address:

Background: The mediator complex consists of 33 subunits and plays a central role in transcription. Studies have already described the involvement of individual subunits, especially in carcinogenesis. With regard to the subunit MED30, this has, so far, only been confirmed in gastric and breast carcinoma. Read More

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June 2018
5 Reads

High expression of PXDN is associated with poor prognosis and promotes proliferation, invasion as well as migration in ovarian cancer.

Ann Diagn Pathol 2018 Jun 14;34:161-165. Epub 2018 Mar 14.

Department of Obstetrics, Daqing People's Hospital, Daqing 163000, China. Electronic address:

Background: Peroxidasin (PXDN) is an extracellular matrix protein with peroxidase activity. PXDN has been reported to participate in the processes of epithelial mesenchymal transition. However, the roles of PXDN in progression of cancers are still rare. Read More

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June 2018
1 Read

PD-L1 immuno-expression assay in thymomas: Study of 84 cases and review of literature.

Ann Diagn Pathol 2018 Jun 4;34:135-141. Epub 2018 Apr 4.

Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address:

Background And Aims: Programmed death ligand 1 (PD-L1), an immune check point inhibitor, is known to be expressed in several malignancies and is being considered as a prognostic factor and a potential immunotherapeutic target. The aim of this study was to characterize PD-L1 expression in thymomas and to determine correlation with clinicopathological features and previously published studies in the literature.

Methods: Tissue microarrays were prepared from selected blocks of thymomas and immunohistochemistry (IHC) for PD-L1 was performed. Read More

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June 2018
6 Reads

Rectal ulcer and pseudomalignant epithelial changes after prostate seed brachytherapy: A rare complication with a diagnostic pitfall.

Ann Diagn Pathol 2018 Jun 4;34:131-134. Epub 2018 Apr 4.

Anatomic Pathology, Albany Medical College, Albany, NY, USA. Electronic address:

Background: Implant brachytherapy (IBT) is a well-recognized treatment modality for early stage prostate cancer. Rectal ulcer and rectourethral fistula complicating IBT may cause an alteration of the normal anatomic landmarks. In this context, pseudomalignant radiation-induced changes within prostatic epithelium may be misinterpreted as a primary rectal malignancy. Read More

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June 2018
1 Read

The Gleason pattern 4 in radical prostatectomy specimens in current practice - Quantification, morphology and concordance with biopsy.

Ann Diagn Pathol 2018 Jun 18;34:13-17. Epub 2017 Dec 18.

Department of Pathology, Faculty of Medicine, Largo do Terreiro de Jesus s/n, Federal University of Bahia, 40025010 Salvador, Brazil; Hospital Universitário Professor Edgard Santos, Rua Augusto Viana, sn, Canela, Salvador 40110060, Brazil.. Electronic address:

Purpose: The upgrading of a prostate acinar adenocarcinoma grade group 1 (GG1) between needle biopsy and prostatectomy is common. The extent of high-grade tumor and cribriform morphology are currently suggested as prognostic factors.

Methods: We reviewed 159 prostatectomy specimens from a private laboratory and an academic/public institution in Salvador, Bahia. Read More

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June 2018
1 Read

Primary breast carcinomas with neuroendocrine features: Clinicopathological features and analysis of tumor growth patterns in 36 cases.

Ann Diagn Pathol 2018 Jun 4;34:122-130. Epub 2018 Apr 4.

Bezmialem University, Faculty of Medicine, Department of Pathology, Turkey.

Primary breast carcinoma with neuroendocrine features (NEBC) is an uncommon tumor. In the classification of WHO 2012, these tumors were categorized as: 1- neuroendocrine tumor, well-differentiated; 2- neuroendocrine carcinoma, poorly differentiated/small cell carcinoma; and 3- invasive breast carcinoma with neuroendocrine differentiation. In this study, we reviewed NEBC except poorly differentiated/small cell carcinoma variant in order to define the morphological growth patterns and cytonuclear details of these tumors. Read More

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June 2018
1 Read

Small cell lymphocytic variant of marginal zone lymphoma: A distinct form of marginal zone lymphoma derived from naïve B cells as a cutaneous counterpart to the naïve marginal zone lymphoma of splenic origin.

Ann Diagn Pathol 2018 Jun 21;34:116-121. Epub 2018 Feb 21.

Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA.

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June 2018
1 Read

Expression and clinical significance of retinoid X receptor α in esophageal carcinoma.

Ann Diagn Pathol 2018 Jun 28;34:110-115. Epub 2018 Mar 28.

Department of Pathology, The Affiliated Southeast Hospital of Xiamen University, Zhangzhou 363000, Fujian Province, China. Electronic address:

Purpose: Esophageal carcinoma (EC) is one of the most aggressive type cancers and dysregulation of retinoid X receptor α (RXRα) involves various tumors. However, the relationship of RXRα with the clinicopathological factors of EC, particularly prognostic characteristics, remains unclear. This present study was to evaluate the effect of RXRα expression in the development of EC. Read More

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June 2018
1 Read

microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.

Ann Diagn Pathol 2018 Jun 26;34:103-109. Epub 2018 Mar 26.

GNOME Diagnostics, Powell, OH 43065, USA; OSU Comprehensive Cancer Center, Columbus, OH 43210, USA. Electronic address:

This study examined the molecular correlates of Down's dementia. qRTPCR for chromosome 21 microRNAs was correlated with in situ hybridization, immunohistochemistry for microRNA targets, mRNAs located on chromosome 21, and neurofibrillary tangles in human and the Ts65 dn mouse Down's model. qRTPCR for the microRNAs on the triplicated chromosome showed miR-155 dominance in brain tissues (14. Read More

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June 2018
1 Read

Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, "undifferentiated small round cell tumors". A clinicopathologic, immunophenotypic and molecular analysis.

Ann Diagn Pathol 2018 Jun 29;34:1-12. Epub 2017 Nov 29.

Pathology Department, University of Valencia, Valencia, Spain.

Background: Despite extensive immunohistochemical (IHC) and molecular studies combined with morphologic findings, a group of round/ovoid cell tumors histologically similar to Ewing sarcomas (ES) but lacking EWSR1-rearrangements may remain unclassifiable.

Design: We retrospectively analyzed 41 Ewing-like tumors (formalin-fixed, paraffin-embedded) previously determined as negative or non-informative for EWSR1-rearrangements by FISH and/or RT-PCR. A new histopathology revision and additional IHC and molecular analyses were carried out in order to investigate whether additional IHC and/or molecular testing in combination with the morphological findings may help in reaching a definitive diagnosis. Read More

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June 2018
3 Reads

Interdigitating dendritic cell sarcoma: Clinicopathologic study of 8 cases with review of the literature.

Ann Diagn Pathol 2018 Jun 30;34:155-160. Epub 2018 Mar 30.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

To investigate the clinicopathologic features and differential diagnoses of interdigitating dendritic cell sarcoma (IDCS), the clinical, morphological and immunohistochemical features of eight cases of IDCS were collected and analyzed. Three patients were males and five were females, the mean age and the median age were 56.5 years and 57 years respectively. Read More

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June 2018
1 Read

Summary of expression of SPARC protein in cutaneous vascular neoplasms and mimickers.

Ann Diagn Pathol 2018 Jun 15;34:151-154. Epub 2018 Mar 15.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Serum protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein, which regulates cell proliferation and facilitates intracellular transport of albumin bound particles including chemotherapeutic agents such as Nab-paclitaxel/ABI-007. Therefore the presence of SPARC may achieve higher intra-tumoral drug concentration with lower dosage and thus reduce systemic side-effects. Several trials of ABI-007, in melanoma, show promising clinical activity. Read More

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June 2018
1 Read

Extrapleural solitary fibrous tumor: A distinct entity from pleural solitary fibrous tumor. An update on clinical, molecular and diagnostic features.

Ann Diagn Pathol 2018 Jun 9;34:142-150. Epub 2018 Apr 9.

Pathology Unit, Department in Support of Oncology Paths, Diagnostic Area, Istituto Nazionale dei Tumori I.R.C.C.S. Fondazione "Pascale", via Mariano Semmola 52, 80131 Naples, Italy.

Solitary fibrous tumor (SFT) is a mesenchymal neoplasm that was originally described to be localized in the pleura, but thereafter, this has been reported in several anatomic sites. Although the etiology of the neoplasm remains largely unknown, the pathogenesis seems to be related to an NAB2-STAT6 fusion gene due to paracentric inversion on chromosome 12q13. The diagnosis of extrapleural SFT is challenging, owing to its rarity, and requires an integrated approach that includes specific clinical, histological, immunohistochemical, and even molecular findings. Read More

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June 2018
1 Read

Composition of the immune microenvironment differs between carcinomas metastatic to the lungs and primary lung carcinomas.

Ann Diagn Pathol 2018 Apr 13;33:62-68. Epub 2017 Dec 13.

Caris Life Sciences, Phoenix, AZ, USA. Electronic address:

Lungs are among the most common sites for development of both primary and metastatic carcinomas. Tumor cells expression (TC) of PD-L1 is an important predictor of the of response to immune check-point inhibition in NSCLC, while the composition of the immune cells (IC) in the tumor microenvironment including PD-L1+ cells is believed to predict responses in tumors of some other primary sites. Total mutational load (TML) and microsatellite instability (MSI) also play a role in response to the immune checkpoint blockade. Read More

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April 2018
8 Reads

Biphenotypic sinonasal sarcoma: A series of six cases with evaluation of role of β-catenin immunohistochemistry in differential diagnosis.

Ann Diagn Pathol 2018 Apr 8;33:6-10. Epub 2017 Nov 8.

Department of Otolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi 110029, India.

Introduction: Biphenotypic sinonasal sarcoma (BSNS) is a recently described mesenchymal tumor exclusive to the sinonasal region. It is a low grade sarcoma, displaying evidence of myogenic and neural differentiation. Role of β-catenin immunohistochemistry in distinguishing it from its morphological mimics is not well-established. Read More

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April 2018
4 Reads

Secretory carcinoma of the parotid with adenoid cystic carcinoma cytological pattern: A cytological-pathological correlation with literature review.

Ann Diagn Pathol 2018 Apr 24;33:58-61. Epub 2017 Dec 24.

Medical College of Wisconsin, Department of Pathology, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, United States. Electronic address:

Secretory carcinoma (SC) is a rare low-grade malignant tumor, defined by ETV6-NTRK3 fusion, identifiable by FISH. We describe a case in a 58-year-old male with a painless slowly growing 16mm palpable mass within left superficial parotid. FNA of the mass showed highly cellular specimen with moderate to large pleomorphic cells with round to ovoid nuclei with vesicular chromatin and distinct nucleoli. Read More

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April 2018
2 Reads

A retrospective analysis of paediatric lymphomas at Chris Hani Baragwanath Academic Hospital in Soweto, South Africa.

Ann Diagn Pathol 2018 Apr 8;33:51-57. Epub 2017 Nov 8.

Department of Anatomical Pathology, National Health Laboratory Service, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

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April 2018
3 Reads

Intraoperative sentinel lymph node evaluation: Optimizing surgical pathology practices in an era of changing clinical management.

Ann Diagn Pathol 2018 Apr 13;33:45-50. Epub 2017 Dec 13.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South CC-3322 Medical Center North, Nashville, TN 37232-2561, United States; Yale University, Department of Pathology, 310 Cedar Street, PO Box 208023, New Haven, CT 06520-8023, United States.

Axillary lymph node status is an independent prognostic indicator in breast cancer. Intraoperative identification of metastatic carcinoma in sentinel lymph nodes may allow for concurrent axillary lymph node dissection at the time of primary tumor excision. A retrospective review of patients undergoing primary breast cancer excision with sentinel lymph node sampling was performed. Read More

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April 2018
3 Reads

High cytoplasmic HuR expression is associated with advanced pT stage, high grade and increased microvessel density in urothelial bladder carcinoma.

Ann Diagn Pathol 2018 Apr 13;33:40-44. Epub 2017 Dec 13.

Department of Pathology, Medical University of Warsaw, Pawińskiego 7, 02-106 Warsaw, Poland.

Purpose: HuR (human antigen R) protein is a RNA binding protein that stabilizes the mRNA and controls the translation of genes involved in cell proliferation, differentiation, and carcinogenesis. Overexpression of HuR was reported in a variety of cancers, however its clinical significance in urothelial bladder cancer (UBC) is still unknown. Our aim is to investigate the association between HuR expression and selected histopathological factors, such as tumor grade, pT stage, regional lymph nodes status and microvessel density (MVD). Read More

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April 2018
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Intra-surgical total and re-constructible pathological prostate examination for safer margins and nerve preservation (Istanbul preserve).

Ann Diagn Pathol 2018 Apr 24;33:35-39. Epub 2017 Nov 24.

Acibadem University, Department of Urology, Istanbul, Turkey.

Purpose: To demonstrate a novel frozen section analysis technique during robot assisted radical prostatectomy with 2 distinct advantages: evaluation of the entire circumference and easier reconstruction for whole mount evaluation.

Material And Methods: Istanbul Preserve was performed on patients who underwent robotic prostatectomy with nerve sparing between 10/2014 and 7/2016. Gland was sectioned at 3-4mm intervals from apex to bladder neck. Read More

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April 2018
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Hodgkin lymphoma with an interfollicular growth pattern: A clinicopathologic study of 8 cases.

Ann Diagn Pathol 2018 Apr 14;33:30-34. Epub 2017 Nov 14.

Pathology Section, Rashid Hospital, Dubai, United Arab Emirates.

Classic Hodgkin lymphoma (CHL) has four subtypes. Different morphologic variations can be seen in lymph nodes involved by CHL. Primary interfollicular (IF) involvement is not considered a separate subtype but an unusual diagnostically challenging morphologic variant. Read More

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April 2018
2 Reads