1,765 results match your criteria Annals of Diagnostic Pathology [Journal]


Mucosal Schwann cell hamartoma of the gastroesophageal junction: A series of 6 cases and comparison with colorectal counterpart.

Ann Diagn Pathol 2020 Apr 28;47:151531. Epub 2020 Apr 28.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States. Electronic address:

Mucosal Schwann cell hamartoma (MSCH) is an uncommon neural lesion characterized by an ill-defined proliferation of S100-positive Schwann cells in the lamina propria, with reported cases exclusively occurring in the colorectum. Here we describe the first series of MSCHs arising in the gastroesophageal junction (GEJ) and discuss their clinicopathologic features in comparison with their colorectal counterparts. We searched the UCLA pathology database from 01/2014 to 12/2018 to identify cases carrying the diagnosis of MSCH. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151531DOI Listing

Oral manifestations of Langerhans cell histiocytosis with unusual histomorphologic features.

Ann Diagn Pathol 2020 May 21;47:151536. Epub 2020 May 21.

Oral and Dental Surgery Unit, Rashid Hospital, Dubai, United Arab Emirates.

Langerhans cell histiocytosis (LCH) is a bone marrow-derived immature myeloid dendritic cell proliferative disorder with diverse clinical manifestations commonly involves bone, skin, lymph node and lung. Oral involvement is uncommon. Intraoral lesions can be the first sign of either a localized LCH or clinically undiagnosed systemic LCH, predates systemic manifestations of LCH, or an early indicator of recurrence in known cases. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151536DOI Listing

Abundant CD8+ tumor infiltrating lymphocytes and beta-2-microglobulin are associated with better outcome and response to interleukin-2 therapy in advanced stage clear cell renal cell carcinoma.

Ann Diagn Pathol 2020 May 19;47:151537. Epub 2020 May 19.

Oregon Health & Science University, Department of Pathology, Portland, OR 97239, United States of America. Electronic address:

Studies assessing tumor-infiltrating lymphocytes (TILs) in clear cell renal cell carcinoma (ccRCC) and clinical outcomes have mixed results. Given fundamental interaction of MHC class I with CD8+ T-cells, we hypothesized that expression of MHC class I associated protein, beta-2-microglobulin (B2M), may be an important immunologic marker in RCC. We sought to understand potential implications of CD8 + TILs and tumor B2M expression on overall survival and response to high-dose interleukin-2 (IL-2) therapy, in a cohort of patients with high-stage (clinical stage III and IV) ccRCC. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151537DOI Listing

Non-small cell lung carcinomas with CTNNB1 (beta-catenin) mutations: A clinicopathological study of 26 cases.

Ann Diagn Pathol 2020 Apr 20;46:151522. Epub 2020 Apr 20.

Department of Pathology, Marie Lannelongue Hospital, 133 avenue de la Résistance, 92350 Le Plessis Robinson, France.

Beta-catenin, encoded by the CTNNB1 gene, plays an important role in cell proliferation. Mutations of CTNNB1 are oncogenic in several tumor types and are often associated with a nuclear abnormal expression. However, such mutations have only rarely been reported in non-small cell lung carcinomas and their clinical signification is not well described. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151522DOI Listing

Detection of cryptic CCND1 rearrangements in mantle cell lymphoma by next generation sequencing.

Ann Diagn Pathol 2020 May 6;46:151533. Epub 2020 May 6.

Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

The accurate detection of recurrent genetic abnormalities for most hematologic neoplasms is critical for diagnosis, prognosis and/or treatment. Rearrangements involving CCND1 are observed in a subset of mature B-cell neoplasms and can be reliably detected by fluorescence in situ hybridization (FISH) in most cases. However, cryptic and complex chromosomal rearrangements may pose a technical challenge for accurate diagnosis. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151533DOI Listing

Morphological features useful in the differential diagnosis between undifferentiated carcinoma and gastrointestinal stromal tumor.

Ann Diagn Pathol 2020 May 3;46:151527. Epub 2020 May 3.

Sikl's Institute of Pathology, Faculty of Medicine and Teaching Hospital in Plzen, Charles University, Plzen, Czech Republic; Bioptical Laboratory, Ltd., Plzen, Czech Republic. Electronic address:

Undifferentiated (sarcomatoid) carcinomas may closely mimic gastrointestinal stromal tumors (GISTs) due to possible histological and immunohistochemical overlap between these two entities. To avoid unnecessary employment of a wide spectrum of immunohistochemical stainings and molecular genetics and thus decrease costs, finding simple morphological features to target further investigation of such neoplasms of the gastrointestinal tract would be helpful. Five cases classified as undifferentiated (sarcomatoid) carcinomas with a definite proof of the diagnosis, i. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151527DOI Listing

Are polyploid giant cancer cells in high grade serous carcinoma of the ovary blastomere-like cancer stem cells?

Ann Diagn Pathol 2020 Mar 18;46:151505. Epub 2020 Mar 18.

Baylor University Medical Center, Department of Pathology, 3600 Gaston Avenue, Dallas, TX 75246, United States of America; University of Texas MD Anderson Cancer Center, Department of Pathology, 1515 Holcombe Blvd. Unit 0072, Houston, TX 77030, United States of America. Electronic address:

Polyploid giant cancer cells, either multinucleated or mononucleated, in high grade serous carcinoma of the ovary have been previously recognized. Different theories including degenerative changes or an important step in the development of high grade serous carcinoma have been proposed. Here we investigate possible explanations for the presence of polyploid giant cancer cells in high grade serous carcinoma. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151505DOI Listing

Analysis of complement deposition and viral RNA in placentas of COVID-19 patients.

Ann Diagn Pathol 2020 Apr 25;46:151530. Epub 2020 Apr 25.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, United States of America. Electronic address:

COVID-19, the disease caused by the novel Coronavirus, SARS-CoV-2, is increasingly being recognized as a systemic thrombotic and microvascular injury syndrome that may have its roots in complement activation. We had the opportunity to study the placental pathology of five full-term births to COVID-19 patients. All five exhibited histology indicative of fetal vascular malperfusion characterized by focal avascular villi and thrombi in larger fetal vessels. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182529PMC

A mechanistic analysis placental intravascular thrombus formation in COVID-19 patients.

Ann Diagn Pathol 2020 Apr 25;46:151529. Epub 2020 Apr 25.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, United States of America. Electronic address:

COVID-19, the disease caused by the novel Coronavirus, SARS-CoV-2, is increasingly being recognized as a systemic thrombotic and microvascular injury syndrome that may have its roots in complement activation. We had the opportunity to study the placental pathology of five full-term births to COVID-19 patients. All five exhibited histology indicative of fetal vascular malperfusion characterized by focal avascular villi and thrombi in larger fetal vessels. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195270PMC

Prognosis in pathology: Are we "prognosticating" or only establishing correlations between independent variables and survival? A study with various analytics cautions about the overinterpretation of statistical results.

Ann Diagn Pathol 2020 Apr 21;46:151525. Epub 2020 Apr 21.

Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

Survival data from 225 patients with resected pulmonary typical carcinoids were analyzed with Kaplan-Meier statistics (K-M) and "deep learning" methods to illustrate the difference between establishing "correlations" and "prognostications". Cases were stratified into G1 and G2 classes using a ≤5% Ki-67% cut-point. Overall survival, number of patients at risk and 95% confidence intervals (CI) were estimated for the two classes. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151525DOI Listing

Central giant cell granuloma: A clinicopathological and immunohistochemical study of macrophages, blood vessels, lymphatic vessels and regulatory proteins.

Ann Diagn Pathol 2020 Apr 20;46:151526. Epub 2020 Apr 20.

Dentistry and Health Postgraduate Program, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil; Laboratory of Oral and Maxillofacial Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address:

Objective: This study seeks to investigate immunohistochemical parameters that could distinguish non-aggressive Central giant cell granuloma (CGCG) from aggressive CGCG, two groups of lesions which differ in their clinical and radiographic features and prognosis.

Material And Methods: 12 cases of non-aggressive CGCG and 11 cases of aggressive CGCG were investigated and associated the immunohistochemical expression of macrophages (CD68 and CD163), blood vessels (CD34 and CD105), lymphatic vessels (D2-40) and regulator proteins (p63 and Ki-67). Clinical and radiographic features were also studied. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151526DOI Listing

From the archives of MD Anderson Cancer Center: BCR-ABL1-like B acute lymphoblastic leukemia with IGH/EPOR fusion.

Ann Diagn Pathol 2020 Apr 15;46:151514. Epub 2020 Apr 15.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151514DOI Listing
April 2020
1.112 Impact Factor

A broad-based approach to differentiate CIN from its mimics: The utility of in situ hybridization and immunohistochemistry.

Authors:
Gerard Nuovo

Ann Diagn Pathol 2020 Apr 13;46:151515. Epub 2020 Apr 13.

The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States of America; Discovery Life Sciences, Powell, OH, United States of America. Electronic address:

The hematoxylin and eosin slides of 100 consecutive cases diagnosed as CIN 1-2 were combined with 25 CIN 1 and 25 negative for CIN as documented by in situ HPV testing. The 150 cases were then reviewed blinded and scored as "CIN" or "negative for CIN". Each of the 50 controls was correctly scored. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151515DOI Listing

mTOR pathway activation in focal cortical dysplasia.

Ann Diagn Pathol 2020 Apr 10;46:151523. Epub 2020 Apr 10.

Institute of Genomics and Integrative Biology - Council of Scientific and Industrial Research, New Delhi, India.

Background: Focal cortical dysplasia (FCD) is a localized cortical malformation and considerable morphological overlap exists between FCD IIB and neurological lesions associated with Tuberous sclerosis complex (TSC). Abnormal mTOR pathway secondary to somatic mTOR mutation and TSC gene mutation linked to PI3K/AKT/mTOR pathway have supported the hypothesis of common pathogenesis involved. Role of converging pathway, viz. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151523DOI Listing

B-cell lymphomas associated with breast implants: Report of three cases and review of the literature.

Ann Diagn Pathol 2020 Mar 28;46:151512. Epub 2020 Mar 28.

Department of Medicine, Hematology/Oncology Division, University of California Irvine (UCI) Medical Center, Orange, CA, United States of America. Electronic address:

Since the first reported case in 1997, over 600 women with breast implant-associated anaplastic large cell lymphoma (BI ALCL) have been reported. BI ALCL is a CD30-positive T-cell lymphoma that carries clonal T-cell receptor gene rearrangements, and a subset of cases harbors mutations in the JAK-STAT signaling pathway. Rarely, other histologic types of lymphoma have been reported in association with breast implants, including fewer than 10 cases of B-cell origin. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151512DOI Listing

Pediatric clear cell meningioma involving the middle cranial fossa in the context of NF2 and SMARCE1 mutations.

Ann Diagn Pathol 2020 Apr 13;46:151516. Epub 2020 Apr 13.

Cleveland Clinic Lerner College of Medicine and Cleveland Clinic Department of Anatomic Pathology, Cleveland, OH, United States of America. Electronic address:

Meningiomas are an uncommon entity in children and adolescents. <30 cases of pediatric clear cell meningioma (CCM), a World Health Organization (WHO) Grade II tumor, have been reported in the literature. These tumors are more likely to recur than the more common WHO Grade I meningiomas, especially with incomplete surgical resection. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151516DOI Listing

1p/19q co-deleted fibrillary astrocytomas: Not everything that is co-deleted is an oligodendroglioma.

Ann Diagn Pathol 2020 Apr 8;46:151519. Epub 2020 Apr 8.

University School and Cleveland Clinic Department of Anatomic Pathology, USA. Electronic address:

The presence of chromosome 1p/19q co-deletion is one of the hallmark required criteria for the diagnosis of oligodendroglioma, using the 2016 World Health Organization (WHO) Classification of Tumours of the Central Nervous System. Descriptions in the literature of astrocytomas, primarily glioblastomas, demonstrating partial losses on one or the other chromosome have been described. The significance of these small deletions is uncertain. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151519DOI Listing

Metastatic atypical meningioma to the parotid gland - A cytopathological correlation.

Ann Diagn Pathol 2020 Apr 6;46:151521. Epub 2020 Apr 6.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

The tumors involving the parotid gland are mainly primary, with metastatic lesions comprising only 5% of malignant salivary gland neoplasms. We are presenting a rare case of metastatic meningioma to the parotid in a 51-year-old male with a past medical history of recurrent atypical meningioma involving the frontal lobe. For the past 1. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151521DOI Listing

Evaluation of deeper levels in initially negative temporal artery biopsies and likelihood of a positive result.

Ann Diagn Pathol 2020 Apr 8;46:151517. Epub 2020 Apr 8.

Department of Pathology, Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, OH 44195, USA. Electronic address:

Giant cell arteritis is a vasculitis that affects large- and medium-sized vessels in patients over the age of 50 years. The demonstration of granulomatous arteritis is the criterion standard to establish a definitive diagnosis. However, temporal arteritis is known to discontinuously involve the artery, and there is no standardization of the number of sections which should be examined in a length of sampled artery. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151517DOI Listing

The expression and prognostic role of IMPDH2 in ovarian cancer.

Ann Diagn Pathol 2020 Mar 23;46:151511. Epub 2020 Mar 23.

Cangzhou Medical College, Cangzhou City, Hebei Province 061001, China. Electronic address:

Object: Inosine 5'-monophosphate dehydrogenase type II (IMPDH2), as an oncogene, is reported to be involved in tumor formation and progression. However, the role of IMPDH2 in ovarian cancer remains unclear. Present study is aimed to investigate the expression and clinical significance of IMPDH2 in ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151511DOI Listing

Should we perform cytokeratin immunostaining in cases of Russell body gastritis?

Ann Diagn Pathol 2020 Apr 6;46:151524. Epub 2020 Apr 6.

Department of General and Clinical pathology, Medical University, Plovdiv, Bulgaria; Service d'Anatomie et Cytologie Pathologiques, Grand Hôpital de l'Est Francilien, Jossigny, France.

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151524DOI Listing

Mapping of parathyroid neoplasms based on grey scale ultrasound images and histopathological whole slide images.

Ann Diagn Pathol 2020 Mar 3;46:151492. Epub 2020 Mar 3.

Department of Endocrinology and Metabolism, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Purpose: In this study, echogenicity and histopathological projections of parathyroid neoplasia in grey mode ultrasonography were compared with whole side imaging (WSI). The utility of the data obtained for clinical assessment was evaluated.

Methods: In 57 patients operated for hyperparathyroidism, the parathyroid gland was sampled in the sagittal plane. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151492DOI Listing

An investigation of European pathologists' approach to diagnose microscopic colitis.

Ann Diagn Pathol 2020 Apr 5;46:151520. Epub 2020 Apr 5.

Department of Pathology, Zealand University Hospital Roskilde, Sygehusvej 9, 4000 Roskilde, Denmark.

Microscopic colitis (MC) comprising lymphocytic colitis (LC), collagenous colitis (CC) and the incomplete forms of microscopic colitis (MCi) are frequent causes of chronic watery diarrhea. The diagnosis is based on specific histological features in colonic biopsies. Especially regarding MCi, the histological features may be subtle. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151520DOI Listing

SATB2 is frequently expressed in ossifying and non-ossifying peripheral oral fibroma of the gingival region but not in reactive fibromatous lesions from other intraoral sites.

Ann Diagn Pathol 2020 Apr 2;46:151510. Epub 2020 Apr 2.

Institute of Pathology, University Hospital, Erlangen, Germany.. Electronic address:

Ossifying and non-ossifying peripheral oral fibromas (POF) of the gingival and alveolar mucosa are localized, cellular, small fibrous nodular lesions likely resulting from diverse external/ internal physical and chemical irritation or injuries. A central nidus of metaplastic woven bone characterizes and defines the ossifying variant. The inherent tendency of these lesions to ossify remains elusive. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151510DOI Listing

Sinonasal papillomas: A single centre experience on 137 cases with emphasis on malignant transformation and EGFR/KRAS status in "carcinoma ex papilloma".

Ann Diagn Pathol 2020 Mar 13;46:151504. Epub 2020 Mar 13.

Institute of Pathology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), University Hospital, Erlangen, Germany. Electronic address:

Among the three major histological subtypes of sinonasal papillomas, inverted (ISP) and oncocytic (OSP) sinonasal papillomas tend to undergo malignant transformation to carcinoma. However, criteria determining risk of recurrence and malignant progression have not been established. Recently, EGFR and KRAS mutations were detected to be characteristic for ISP and OSP, respectively. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151504DOI Listing
March 2020
1.112 Impact Factor

Benign vascular anomalies: A transition from morphological to etiological classification.

Ann Diagn Pathol 2020 Mar 13;46:151506. Epub 2020 Mar 13.

Department of Radiodiagnosis, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi 110031, India.

The International Society for the Study of Vascular Anomalies (ISSVA) devised a multidisciplinary etiopathogenesis based approach to classify benign vascular anomalies into tumors and malformations. This classification scheme has major therapeutic and prognostic implications as treatment modalities differ for both the categories. Inappropriate usage of the term "hemangioma" for etiopathogenetically distinct entities is commonly seen in clinical practice leading to delivery of incorrect treatment to the patients. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151506DOI Listing

Prolactin receptor expression as a novel prognostic biomarker for triple negative breast cancer patients.

Ann Diagn Pathol 2020 Mar 13;46:151507. Epub 2020 Mar 13.

Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.

Prolactin receptor (PRLR) is a novel emerging prognostic biomarker in different cancers, especially in breast cancer. However, there is limited information about the association of PRLR expression and triple-negative breast cancers (TNBC) prognosis. In this study, 80 TNBC patients were evaluated for PRLR expression by immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151507DOI Listing

Presence of tumor cells in the vagina during surgical treatment could be the source of vaginal recurrence in patients with endometrial carcinoma - A pilot prospective study.

Ann Diagn Pathol 2020 Mar 13;46:151503. Epub 2020 Mar 13.

Department of Pathology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

Background: The commonest site of recurrence in endometrial cancer (EC) is the vagina, with a rate of 16%. The aim of this study was to determine if vaginal recurrences in EC patients could develop due to contamination of the vagina with glandular tumor cells dropping off on polypoid, large size EC or tumors involving the endocervix, through manipulation of the uterus during surgery.

Methods: This pilot prospective study included 10 consecutive patients with EC, surgically treated with hysterectomy and additional lymphadenectomy according to stage. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151503DOI Listing

Clinical and histopathologic characteristics of patients undergoing surgical excision with Essure coils: Longitudinal experience at a women's specialty hospital.

Authors:
Natalie Banet

Ann Diagn Pathol 2020 Mar 13;46:151508. Epub 2020 Mar 13.

Department of Pathology and Laboratory Medicine, Women & Infants Hospital and the Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA.. Electronic address:

The introduction of the Essure (Bayer AG, Leverkusen, Germany) device made possible a less invasive approach for patients desiring sterilization. Following FDA approval in 2002, problems were reported in some patients with these devices including most commonly pain. Labeling changes were mandated in 2016, and as of late 2018, the devices are no longer being sold in the United States. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151508DOI Listing

Histological subtypes in triple negative breast cancer are associated with specific information on survival.

Ann Diagn Pathol 2020 Mar 3;46:151490. Epub 2020 Mar 3.

Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands.

Much research has focused on finding novel prognostic biomarkers for triple negative breast cancer (TNBC), whereas only scattered information about the relation between histopathological features and survival in TNBC is available. This study aims to explore the prognostic value of histological subtypes in TNBC. A multicenter retrospective TNBC cohort was established from five Dutch hospitals. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151490DOI Listing

Immunohistochemical staining of podoplanin is helpful in determining the microinvasion of cervical squamous cell carcinoma.

Ann Diagn Pathol 2020 Mar 3;46:151493. Epub 2020 Mar 3.

Department of Pathology, School of Medicine, Shandong University, Jinan, Shandong, China; Department of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address:

Cervical squamous cell carcinoma develops through a series of stages, including low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), microinvasive squamous cell carcinoma (MISCC), and invasive squamous cell carcinoma (ISCC). The difference between HSIL and MISCC is the appearance of microinvasion, which determines the treatment for patients. However, sometimes it is difficult to differentiate HSIL from MISCC in morphology, and no effective markers are available to help determine microinvasion. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151493DOI Listing

Gross tumor size using the AJCC 8th ed. T staging criteria does not provide prognostic stratification for neoadjuvant treated pancreatic ductal adenocarcinoma.

Ann Diagn Pathol 2020 Mar 6;46:151485. Epub 2020 Mar 6.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

The 8th edition AJCC T stage criteria for pancreatic ductal adenocarcinoma (PDAC) are now size based. These criteria provide better prognostic stratification in patients without neoadjuvant therapy. Our aim was to determine if gross tumor size is prognostically significant using the 8th ed. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151485DOI Listing

Downregulation of serum miR-194 predicts poor prognosis in osteosarcoma patients.

Ann Diagn Pathol 2020 Mar 3;46:151488. Epub 2020 Mar 3.

Department of Orthopedics, Daping Hospital, Army Medical University, Chongqing 400010, China. Electronic address:

Background: Circulating microRNAs (miRNAs) have promising potential as diagnostic and prognostic biomarkers for osteosarcoma. This study aimed to explore the expression pattern of serum miR-194 and its potential clinical value in patients with osteosarcoma.

Methods: Messenger RNA was isolated from serum sample from 124 osteosarcoma patients, 60 periostitis patients and 60 healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151488DOI Listing

Lymphomatoid papulosis in children and adolescents: A clinical and histopathologic retrospective cohort.

Ann Diagn Pathol 2020 Mar 3;46:151486. Epub 2020 Mar 3.

Weill Cornell Medical College, Department of Pathology & Laboratory Medicine, New York, NY, United States of America.

Background, Aims And Objectives: Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder that is rare and not well described within the pediatric subpopulation. We sought to review the literature and characterize clinical and pathologic features among pediatric and adolescent patients diagnosed with LyP at a tertiary care center.

Materials And Methods: A retrospective cohort of 27 pediatric and adolescent patients (defined as <20 years old) diagnosed with LyP at the Weill Cornell Medicine Dermatopathology division from 2006 to 2016 was identified. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151486DOI Listing

Current state of Grand Rounds in U.S. pathology training programs.

Ann Diagn Pathol 2020 Mar 3;46:151484. Epub 2020 Mar 3.

Department of Pathology, Loyola University Medical Center, Maywood, IL, United States of America. Electronic address:

Grand Rounds are held with variable frequency in many academic pathology departments, but their exact goal is uncertain, and the type of subjects covered, and presenters have not been studied. We aimed to gather information about the current state of pathology grand rounds (PGR). We identified all US pathology residency programs accredited by the Accreditation Council for Graduate Medical Education (ACGME) and searched their websites for information regarding PGR, extracting data on their existence, frequency and timing. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151484DOI Listing

Histology of the normal ovary in premenopausal patients.

Ann Diagn Pathol 2020 Feb 4;46:151475. Epub 2020 Feb 4.

Baylor Hospital, Dallas, TX, USA.

Detailed descriptions of ovarian histology are rare. We reviewed in detail 57 cases of normal ovaries in premenopausal patients, when the ovaries are active and primordial follicles are found. We also proposed updated definitions to more clearly distinguish inclusion cysts, which do not have a known relationship with any disease process, from endosalpingiosis, a lesion closely associated with low grade serous neoplasia of the ovary. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151475DOI Listing
February 2020

Validation of the T category for distal cholangiocarcinoma: Measuring the depth of invasion is complex but correlates with survival.

Ann Diagn Pathol 2020 Mar 3;46:151489. Epub 2020 Mar 3.

Department of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20 Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do 50612, Republic of Korea. Electronic address:

According to the current 8th edition of the American Joint Committee of Cancer (AJCC), the T category of distal cholangiocarcinomas is classified based on the depth of invasion (DOI) (T1, < 5 mm; T2, between 5 and 12 mm; T3, > 12 mm). In consideration of the discrepancies between previous studies about the prognostic significance, we aimed to validate the current AJCC T staging system of distal cholangiocarcinomas. DOI was measured using three different methods: DOI1, DOI2, and DOI3. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151489DOI Listing

Correlation of Clinicopathological Features and LGR5 Expression in Triple-Negative Breast Cancer.

Ann Diagn Pathol 2020 Mar 3;46:151491. Epub 2020 Mar 3.

Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery (II), , Shinshu University School of Medicine, Matsumoto, Japan.

LGR5 is the most robust known stem cell marker for gastrointestinal tumors, but there are few reports in breast cancer. Triple negative breast cancer (TNBC) is the most malignant subtype of breast cancer, and thus identification of new cancer stem cell populations in TNBC may help to identify targeted therapies. LGR5 expression was evaluated by RNAscope, a newly developed RNA in situ hybridization technique, using a tissue microarray consisting of 43 patient samples of TNBC selected from the medical archives at our hospital. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151491DOI Listing

TFE3 rearranged epithelioid hemangioendothelioma of bone: A clinicopathological, immunohistochemical and molecular study of two cases.

Ann Diagn Pathol 2020 Mar 3;46:151487. Epub 2020 Mar 3.

Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address:

Epithelioid hemangioendothelioma (EHE) is a rare malignant angiocentric vascular neoplasm. Around 90% of classic EHE has a t(1;3)(p36;q25) that results in a WWTR1-CAMTA1 fusion gene, a histologically distinctive subset of EHE has been recently shown to have a t(10;14)(p13;q42)that results in a different fusion gene, YAP1-TFE3. Twenty-one cases of TFE3 Rearranged Epithelioid Hemangioendothelioma have been reported in the literature, and only two cases occurred in bone. Read More

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MAPK7 variants related to prognosis and chemotherapy response in osteosarcoma.

Ann Diagn Pathol 2020 Feb 19;46:151482. Epub 2020 Feb 19.

Pediatric Oncology Institute (GRAACC), Federal University of São Paulo, Department of Pediatrics, São Paulo, SP, Brazil; Federal University of São Paulo, Department of Morphology and Genetics, São Paulo, SP, Brazil; Federal University of São Paulo, Department of Clinical and Experimental Oncology, São Paulo, SP, Brazil. Electronic address:

Osteosarcoma (OS) is a class of cancer originating from the bone, affecting mainly children and young adults. Our previous study showed that MAPK7 gene overexpression was significantly associated with tumor progression, poor treatment response, and worse overall survival, suggesting that MAPK7 could play an important role in OS tumorigenesis. We have investigated if MAPK7 overexpression was a result of any genomic changes in OS tumor specimens. Read More

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February 2020

Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma.

Ann Diagn Pathol 2020 Feb 25;46:151483. Epub 2020 Feb 25.

Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

B7-H3 and EpCAM are overexpressed in cancer and play a role in tumorigenesis and metastasis. In this study, the membranous, cytoplasmic and nuclear expression levels of B7-H3 and EpCAM biomarkers were mapped in three major subtypes of renal cell carcinoma (RCC). Expression of B7-H3 and EpCAM were evaluated using immunohistochemistry in RCC samples on tissue microarrays (TMAs), including clear cell RCCs (ccRCCs), type I and II papillary RCCs (pRCCs), and chromophobe RCCs (chRCCs). Read More

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February 2020
1.112 Impact Factor

Isolated tumor cells in the regional lymph nodes in patients with squamous cell carcinoma of the esophagus are rarely observed but often represent part of a true metastasis.

Ann Diagn Pathol 2020 Apr 14;45:151478. Epub 2020 Feb 14.

Department of Pathology, University Hospital of Copenhagen, Rigshospitalet, Frederik V's Vej 11, 2100 Copenhagen, Denmark. Electronic address:

The most common malignancy of the esophagus is squamous cell carcinoma (SCC) and regional lymph node metastases are an important prognostic factor. Isolated tumor cells (ITCs) are defined as single tumor cells or small clusters of tumor cells not exceeding 0.2 mm. Read More

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American Registry of Pathology Expert Opinions: The Spectrum of Lobular Carcinoma in Situ: Diagnostic Features and Clinical Implications.

Ann Diagn Pathol 2020 Apr 15;45:151481. Epub 2020 Feb 15.

University of Queensland and Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, Australia.

This review reflects a collaboration between the American Registry of Pathology (the publisher of the Armed Forces Institute of Pathology Fascicles) and Annals of Diagnostic Pathology. It is part of a series of expert recommendations on topics encountered in daily practice. The authors, 4 pathologists with expertise in breast pathology and a breast surgeon with a clinical and research interest in lobular carcinoma in situ (LCIS), met by conference call in September 2019 to develop recommendations for evaluating and reporting LCIS. Read More

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Association between focal adhesion kinase and matrix metalloproteinase-9 expression in prostate adenocarcinoma and their influence on the progression of prostatic adenocarcinoma.

Ann Diagn Pathol 2020 Apr 14;45:151480. Epub 2020 Feb 14.

Department of Urology, Baskent University, Faculty of Medicine, Bahcelievler, Ankara, Turkey.

Focal adhesion kinase (FAK), a member of the non-receptor cytoplasmic tyrosine kinase family, is associated with the development and progression of cancer. Matrix metalloproteinase-9 (MMP-9) is directly involved in the degradation of the extracellular matrix, and basement membrane components promote cancer cell migration and invasion. There is a functional interaction among FAK, MMP-9 and vascular endothelial growth factor (VEGF), which leads to enhanced cancer angiogenesis, cancer cell invasion and progression of malignancy. Read More

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Spectrum of histological features of Denosumab treated Giant Cell Tumor of Bone; potential pitfalls and diagnostic challenges for pathologists.

Ann Diagn Pathol 2020 Apr 14;45:151479. Epub 2020 Feb 14.

Section of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan. Electronic address:

Objectives: Denosumab is Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) inhibitor which is being used in the treatment of locally advanced, recurrent and metastatic Giant Cell Tumor of Bone (GCTB). It causes reduction in monocyte recruitment and Osteoclast-Like Giant Cell (OLGC) formation which limits bone destruction. After Denosumab treatment, GCTB exhibit diverse morphological features which can pose diagnostic challenge. Read More

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April 2020
1.112 Impact Factor

Clinicopathologic and immunohistochemical characteristics of upper gastrointestinal leiomyomas harboring interstitial cells of Cajal: A potential mimicker of gastrointestinal stromal tumor.

Ann Diagn Pathol 2020 Apr 5;45:151476. Epub 2020 Feb 5.

Koç University Hospital, Department of Pathology, Turkey.

Objective: To analyze clinicopathologic characteristics of upper gastrointestinal leiomyomas and to determine the distribution and immunohistochemical features of interstitial cells of Cajal, in order to designate whether they can cause diagnostic challenges.

Materials And Methods: Twenty-four upper gastrointestinal leiomyomas (14 esophagus, 10 stomach) were retrieved. CD117, DOG-1 and muscle markers were performed. Read More

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Cardiac paragangliomas: A case series with clinicopathologic features and succinate dehydrogenase B immunostaining.

Ann Diagn Pathol 2020 Apr 5;45:151477. Epub 2020 Feb 5.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address:

Cardiac paragangliomas (PGs) are very rare tumors that comprise less than 1% of all cardiac tumors. PGs can occur sporadically, but inherited syndromes may also play a role in the development of PGs. Approximately one-third of PGs are associated with mutations in the succinate dehydrogenase (SDH) complex, specifically SDHB, as part of syndrome-associated PGs or sporadic PGs. Read More

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Reconsideration of the first recognition of breast implant-associated anaplastic large cell lymphoma: A critical review of the literature.

Ann Diagn Pathol 2020 Apr 29;45:151474. Epub 2020 Jan 29.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

The current literature credits Keech and Creech with the first report of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in 1997. Here we discuss what we consider is the first ever description of BIA-ALCL, a recently recognized entity by the WHO. We unearthed the description of a patient that was diagnosed with primary effusion lymphoma (PEL), surrounding a breast implant in 1996. Read More

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