1,597 results match your criteria Annals of Diagnostic Pathology [Journal]


Fumarate hydratase deficient renal cell carcinoma: Chromosomal numerical aberration analysis of 12 cases.

Ann Diagn Pathol 2019 Feb 10;39:63-68. Epub 2019 Feb 10.

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzeň, University Hospital Plzen, Pilsen, Czech Republic. Electronic address:

Hereditary leiomyomatosis and renal cell carcinoma-associated renal cell carcinoma (HLRCC)/fumarate hydratase deficient renal cell carcinoma (FHRCC) is defined by molecular genetic changes (mutation/LOH in fumarate hydratase (FH) gene). We investigated chromosomal numerical aberration pattern (CNV) in FHRCC/HLRCC using array comparative genomic hybridization analysis and low pass whole genome sequencing. Genetic analysis was successfully completed in 12 tumors. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.008DOI Listing
February 2019

Prostatic ductal adenocarcinoma with cribriform architecture has worse prognostic features than non-cribriform-type.

Ann Diagn Pathol 2019 Feb 10;39:59-62. Epub 2019 Feb 10.

Department of Pathology and Laboratory Medicine, BC Cancer Agency, Vancouver, BC, Canada. Electronic address:

Prostatic ductal adenocarcinoma (PDA) is a rare histologic subtype of prostate cancer characterized by large glands lined with tall columnar pseudostratified epithelium. PDA has several architectural patterns, with papillary and cribriform being the most common. The cribriform pattern of acinar carcinoma has shown to be associated with a worse prognosis in terms of disease progression and disease-specific mortality. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.007DOI Listing
February 2019

The frequency of NOTCH1 variants in T-acute lymphoblastic leukemia/lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma among Jordanian patients.

Ann Diagn Pathol 2019 Jan 24;39:53-58. Epub 2019 Jan 24.

Department of Physiology and Biochemistry, School of Medicine, The University of Jordan, Amman, Jordan. Electronic address:

The transmembrane receptor NOTCH1 is thought to be associated with the development and progression of T-acute lymphoblastic leukemia (T-ALL)/T-lymphoblastic lymphoma (T-LBL) and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The current study aimed to characterize NOTCH1 expression and elucidate the variants in the functional PEST domain of the receptor in T-ALL/LBL and CLL/SLL. The nuclear expression of NOTCH1 protein was detected in 25% and 5% of cases of T-ALL/LBL and CLL/SLL, respectively, whereas cytoplasmic expression was detected in 33. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.01.004DOI Listing
January 2019
1 Read
1.112 Impact Factor

Fatty acid synthase, Her2/neu, and E2F1 as prognostic markers of progression in non-muscle invasive bladder cancer.

Ann Diagn Pathol 2019 Jan 17;39:42-52. Epub 2019 Jan 17.

Surgical Oncology Department, Al-Ahrar Zagazig Teaching Hospital, Egypt.

Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease which has an unpredictable risk of progression to muscle-invasive bladder cancer (MIBC). The selection of patients who may benefit from early radical intervention is a challenge. To define the useful prognostic markers for progression, we analyzed the immunohistochemical expression of fatty acid synthase (FASN), Her2/neu, and E2F1 in 60 cases of NMIBC who underwent TURBT and adjuvant intravesical bacillus-Calmette-Guérin (BCG). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.01.002DOI Listing
January 2019
1 Read
1.112 Impact Factor

Dedifferentiated gastrointestinal stromal tumor: Recent advances.

Ann Diagn Pathol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital and Weill Medical College of Cornell University, Houston, TX 77030, USA. Electronic address:

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal lesions of the gastrointestinal tract. A small minority of GISTs exhibit morphologic and phenotypic changes and differentiate into an unusual phenotype through the process of dedifferentiation. Dedifferentiation can occur either de novo or after prolonged treatment with imatinib, a selective tyrosine kinase inhibitor. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.005DOI Listing
December 2018
5 Reads

Undifferentiated endometrial carcinoma: A selected immunohistochemical panel including PAX-8 and E-cadherin for aiding distinction from other endometrial carcinomas.

Ann Diagn Pathol 2019 Jan 10;39:36-41. Epub 2019 Jan 10.

Department of Surgical Pathology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, PR China.

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http://dx.doi.org/10.1016/j.anndiagpath.2019.01.001DOI Listing
January 2019
1 Read

Mutation profiling in the PIK3CA, TP53, and CDKN2A genes in circulating free DNA and impalpable breast lesions.

Ann Diagn Pathol 2019 Jan 3;39:30-35. Epub 2019 Jan 3.

Circulating Biomarkers Laboratory, Faculty of Medical Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-170, Brazil; Graduate Program in Medical Sciences, Rio de Janeiro State University, Rio de Janeiro 20550-170, Brazil. Electronic address:

Breast impalpable lesions have become a clinical dilemma because they are small, presenting a heterogeneous cellular phenotype. The aim of this study was to evaluate the mutational profile of the PIK3CA, TP53, and CDKN2A genes, comparing the mammary tissue with the respective circulating free DNA (cfDNA). The PIK3CA, TP53, and CDKN2A genes were sequenced (PCR-Sanger) in 58 women with impalpable lesions (49 malignant and 9 benign) with the respective cfDNA. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.008DOI Listing
January 2019
6 Reads

Retroperitoneal low grade endometrial stromal sarcoma with florid endometrioid glandular differentiation: Cytologic-histologic correlation and differential diagnosis.

Ann Diagn Pathol 2018 Dec 28;39:25-29. Epub 2018 Dec 28.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

Low grade endometrial stromal sarcoma (LGESS) is a rare neoplasm that typically arises in the uterine corpus and accounts for less than 1% of uterine sarcomas. Infrequently, extra-uterine LGESS can occur. Histologically, LGESS is characterized by a monotonous population of cells that resemble the proliferative phase of endometrial stroma and in their classic form they exhibit tongue-like growth pattern of infiltration and/or lymphovascular invasion. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.006DOI Listing
December 2018
1 Read

Processing the entire capsule in thyroid follicular lesions improves diagnostic accuracy.

Ann Diagn Pathol 2018 Dec 23;39:21-24. Epub 2018 Dec 23.

St. John Hospital and Medical Center, Detroit, MI, USA.

Background: There is contradictory evidence in literature with respect to diagnosis and management of follicular lesions of the thyroid gland. From surgical pathology stand point, pathologists require submission and processing of entire capsule for microscopic evaluation. This can be extremely challenging especially in larger lesions. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.007DOI Listing
December 2018
3 Reads

Fine needle aspiration of non-thyroidal head and neck masses: Correlation of the cyto-histopathological diagnoses, causes of inconsistency and traps.

Ann Diagn Pathol 2018 Dec 18;39:15-20. Epub 2018 Dec 18.

Department of Pathology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.004DOI Listing
December 2018
2 Reads

Diagnostic and reporting issues of preneoplastic polyps of the large intestine with early carcinoma.

Authors:
Dale C Snover

Ann Diagn Pathol 2018 Dec 22;39:1-14. Epub 2018 Dec 22.

The University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, 240 Delaware St SE, Minneapolis, MN 55455, USA. Electronic address:

Premalignant polyps of the large intestine are common specimens in surgical pathology. They consist of several different subtypes identifiable by histological criteria that are associated with different molecular characteristics and with the development of different types of colorectal carcinoma. The most common of these is the conventional adenoma, which most commonly leads to carcinomas with a low degree of methylation (CIMP-L) that are microsatellite stable. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.001DOI Listing
December 2018
2 Reads

Aberration of Nrf2‑Bach1 pathway in colorectal carcinoma; role in carcinogenesis and tumor progression.

Ann Diagn Pathol 2019 Feb 22;38:138-144. Epub 2018 Nov 22.

Department of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Nrf2 and Bach1 are important transcriptional factors that protect against reactive oxygen species (ROS). Although aberration of these molecules was associated with malignant transformation and progression, their aberration pattern in colorectal carcinoma (CRC) is not yet fully studied. In this study, Nrf2 and Bach1 were immunohistochemically examined in 93 formalin-fixed paraffin-embedded blocks of colonic tumors (65 carcinoma with their corresponding surgical margins and 28 adenomas). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.003DOI Listing
February 2019
1 Read

Update on the pathology of liver neoplasms.

Ann Diagn Pathol 2019 Feb 12;38:126-137. Epub 2018 Oct 12.

Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, United States of America; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America. Electronic address:

Many advances have developed in the pathology of liver tumors in the recent decade. Examples of these advances include the use of glutamine synthetase in the diagnosis of focal nodular hyperplasia, subtyping of hepatocellular adenomas using molecular and immunohistochemical methods, the unraveling of the fusion transcript between the DNAJB1 gene and the PRKACA gene in fibrolamellar carcinoma, and the more unified classification and terminology in intrahepatic bile duct tumors and their precursor lesions. Nevertheless, challenges still remain, e. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.005DOI Listing
February 2019
3 Reads

Sclerosing Kaposi's sarcoma of the adrenal gland in an HIV-infected patient under antiretroviral therapy.

Ann Diagn Pathol 2019 Feb 14;38:123-125. Epub 2018 Dec 14.

Department of Pathology, Hospital Clínic de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.003DOI Listing
February 2019
1 Read

The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of the uterine cervix.

Ann Diagn Pathol 2019 Feb 14;38:115-122. Epub 2018 Dec 14.

The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA; Phylogeny Inc, Powell, OH, USA. Electronic address:

Importin-β, exportin-5, p16, Ki-67, Mcl1, PDL1, and cFLIP are each over-expressed in the majority of CIN 1 lesions. These biomarkers, plus HPV E6/E7 RNA, were analyzed in carcinoma-in-situ (CIS), microinvasive, and squamous cell carcinoma (SCC) of the uterine cervix and cervical carcinoma cell lines. Only p16 and Ki-67 continued to be over-expressed in CIS, with a concomitant marked increase in E6/E7 RNA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183038
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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.001DOI Listing
February 2019
7 Reads

Hit or a miss: Concordance between histopathologic-endoscopic findings in gastric mucosal biopsies.

Ann Diagn Pathol 2019 Feb 14;38:106-114. Epub 2018 Dec 14.

Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, United States of America. Electronic address:

Background: Current literature shows a variable degree of concordance between endoscopic and histopathologic findings in gastric mucosal biopsies. Most prior studies have focused on specific gastric entities such as gastritis in patients with high prevalence of Helicobacter pylori (H. pylori). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183032
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http://dx.doi.org/10.1016/j.anndiagpath.2018.12.002DOI Listing
February 2019
13 Reads

Post-thymic CD4 positive cytotoxic T cell infiltrates of the skin: A clinical and histomorphologic spectrum of the unique CD4 positive T cell of immunosenescence.

Ann Diagn Pathol 2019 Feb 27;38:99-105. Epub 2018 Oct 27.

Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

T cell lymphoproliferative disorders that arise in the skin are mainly derived from post thymic T cells most commonly of CD4 subset. Human CD4 positive T cells are dynamic exhibiting phenotypic and functional malleability. For example, with repetitive antigen exposure most commonly associated with age, CD4 positive T cells acquire a cytotoxic phenotype. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183031
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.010DOI Listing
February 2019
7 Reads

Measured residual tumor cellularity correlates with survival in neoadjuvant treated pancreatic ductal adenocarcinomas.

Ann Diagn Pathol 2019 Feb 5;38:93-98. Epub 2018 Nov 5.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.013DOI Listing
February 2019
2 Reads

Clinicopathological study of role of CD34 expressions in the stroma of premalignant and malignant lesions of uterine cervix.

Ann Diagn Pathol 2019 Feb 29;38:87-92. Epub 2018 Nov 29.

Department of Pathology, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh, India.

CD34 is a transmembrane glycoprotein that is thought to be involved in the modulation of cell adhesion and signal transduction. The connective tissue stroma of virtually all human organs contain large amounts of resident CD34+ fibrocytes, which are involved in multiple functions such as wound healing, secretion of cytokines and also participate in stromal remodeling. It has been seen in various studies that absence of CD34+ fibrocytes within the stroma is associated with invasive carcinomas. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.007DOI Listing
February 2019
10 Reads

Papillary pattern in clear cell renal cell carcinoma: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 23 cases.

Ann Diagn Pathol 2019 Feb 22;38:80-86. Epub 2018 Nov 22.

Department of Pathology, Charles University, Faculty of Medicine in Plzeň, Pilsen, Czech Republic. Electronic address:

Clear cell renal cell carcinoma (ccRCC), the most common histologic subtype of RCCs, demonstrates a wide spectrum of morphologic features (i.e., low-grade spindle cell, syncytial giant cells, and mucin-producing cells). Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.004DOI Listing
February 2019
4 Reads
1.112 Impact Factor

Carcinoid tumors of the thymus and Cushing's syndrome: Clinicopathologic features and current best evidence regarding the cell of origin of these unusual neoplasms.

Ann Diagn Pathol 2019 Feb 22;38:71-79. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.006DOI Listing
February 2019
3 Reads

FOXP3 and CD25 double staining antibody cocktails identify regulatory T cells in different types of tumor tissues using tissue microarrays.

Ann Diagn Pathol 2019 Feb 22;38:67-70. Epub 2018 Nov 22.

Department of Pathology, University of Texas McGovern Medical School, Houston, TX, 77030, United States of America. Electronic address:

Regulatory T cells (Tregs) are CD4+ T cells that express CD25 and transcription factor Forkhead box P3 (FOXP3), and Tregs play a central role in regulation of tumor immunity. FOXP3 immunohistochemistry has been widely used to study Tregs in paraffin embedded tissue, and flow cytometry using fresh tissue has been used to identify FOXP3+/CD25+ double positive Tregs. In our study, we validated the FOXP3/CD25 double staining antibody cocktails for detecting Tregs in paraffin-embedded tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183034
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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.005DOI Listing
February 2019
8 Reads

Levels of CD8+ tumor infiltrating lymphocytes correlate with disease burden in bone marrow of therapy Naïve multiple myeloma patients.

Ann Diagn Pathol 2018 Nov 28. Epub 2018 Nov 28.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183037
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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.008DOI Listing
November 2018
10 Reads

Somatostatin receptor SSTR2A and SSTR5 expression in neuroendocrine breast cancer.

Ann Diagn Pathol 2019 Feb 20;38:62-66. Epub 2018 Nov 20.

"Ljudevit Jurak" Department of Pathology and Cytology, Clinical Hospital Center "Sestre milosrdnice", Vinogradska cesta 29, 10000 Zagreb, Croatia. Electronic address:

Neuroendocrine breast cancer (NEBC) is a group of rare tumors, which could benefit from therapy targeting the somatostatin receptors (SSTRs). In particular, SSTR2A and SSTR5 are potential targets given their consistent expression in gastrointestinal and pancreatic primary and metastatic neuroendocrine cancers. Currently, there are no studies describing the expression of SSTRs in NEBC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183032
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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.002DOI Listing
February 2019
12 Reads
1.112 Impact Factor

Gene and protein expression of E-cadherin and NCAM markers in non-functioning pituitary adenomas.

Ann Diagn Pathol 2019 Feb 9;38:59-61. Epub 2018 Oct 9.

Postgraduate Program in Pathology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), R. Sarmento Leite, 245 - Centro Histórico, 90050-170 Porto Alegre, RS, Brazil; Neuroendocrinology Center, Complexo Hospitalar Santa Casa, Av. Independência, 75 - Independência, Porto Alegre - RS, 90035-072 Porto Alegre, RS, Brazil.

Non-functioning pituitary adenomas (NFPA) are classified as benign tumors of slow growth, but 40% of them present local invasion, a characteristic of behavior still unpredictable with the use of current tumor markers. This work aims to evaluate the tissue markers E-cadherin and NCAM, which act on cell adhesion, in tumor tissue samples of NFPA and its relationship with the degree of local invasiveness. Gene expression of E-cadherin (CDH1) and NCAM (NCAM1) was assessed by real-time PCR and tissue expression by immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.003DOI Listing
February 2019
3 Reads

Thyroid tumors with follicular architecture.

Ann Diagn Pathol 2019 Feb 18;38:51-58. Epub 2018 Oct 18.

Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL, United States of America. Electronic address:

Thyroid tumors with follicular architecture encompass a considerable array of distinct entities. These lesions share significant morphologic overlap, but portend different prognostic and therapeutic implications. Due to their similar growth patterns, distinction between these tumors can be difficult; remarkable interobserver variability exists, even between expert endocrine pathologists. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183032
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.007DOI Listing
February 2019
4 Reads

Well-differentiated papillary mesothelioma: A 17-year single institution experience with a series of 75 cases.

Ann Diagn Pathol 2019 Feb 28;38:43-50. Epub 2018 Oct 28.

Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

We present our experience with 75 cases of well-differentiated papillary mesothelioma (WDPM) that were diagnosed at our institution between 2000 and 2017. The patients included 58 females and 17 males with age ranging from 18 to 69 years (mean, 42 years). Clinically, the vast majority of WDPMs were incidental findings during laparotomy or laparoscopic surgery for a variety of benign or malignant disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183032
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.012DOI Listing
February 2019
10 Reads

Virus-associated carcinomas of the head & neck: Update from the 2017 WHO classification.

Ann Diagn Pathol 2019 Feb 22;38:29-42. Epub 2018 Oct 22.

Department of Anatomic Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.

Virus-associated carcinomas of the head and neck represent an unusual confluence of infections spread by viral transmission and cellular dysregulation resulting in carcinogenesis. While much remains to be elucidated about the exact progression from infection to cancer, a basic framework of viral biology can complement the pathologist's understanding of morphology. This context informs the pathologist's everyday practice, including selecting ancillary studies, communicating prognostically relevant findings, and participating in treatment planning. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183032
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.008DOI Listing
February 2019
15 Reads

The impact of reporting tumor size in breast core needle biopsies on tumor stage: A retrospective review of five years of experience at a single institution.

Ann Diagn Pathol 2019 Feb 13;38:26-28. Epub 2018 Oct 13.

A.M. Rywlin, MD Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL, United States of America; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States of America.

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.002DOI Listing
February 2019
6 Reads

Localization of TNF alpha in ileocolonic biopsies of patients with inflammatory bowel disease.

Ann Diagn Pathol 2019 Feb 27;38:20-25. Epub 2018 Oct 27.

Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia School of Medicine, Perugia, Italy.

Background: Although antitumor necrosis factor alfa (TNFα) agents are widely used to treat patients with inflammatory bowel diseases (IBD) - both Crohn's disease (CD) and ulcerative colitis (UC) - there is still some uncertainty in the cell type expressing TNFα in human ileo-colonic segments.

Aims: We investigated the immunohistochemical (IHC) expression of TNFα in the ileo-colonic segments of patients with both active CD and UC, to establish its anatomic and cellular localization in the inflamed sites. Our aim was to identify patients potentially resistant to anti TNFα agents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183018
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.011DOI Listing
February 2019
5 Reads

Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues.

Ann Diagn Pathol 2019 Feb 2;38:6-10. Epub 2018 Oct 2.

Neogenomics, Aliso Viejo, CA, United States of America; M.D. Anderson Cancer Center, University of Texas, Department of Hematopathology, Houston, TX, United States of America. Electronic address:

The recent 2017 update of the World Health Organization classification of lymphomas has significant changes from the previous edition. Subtypes of large B cell lymphoma and related aggressive B cell lymphomas are addressed. Clinicopathological features of entities as related to morphology, immunophenotype, cell of origin, and molecular/genetic findings are reviewed with emphasis on changes or updates in findings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183028
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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.014DOI Listing
February 2019
15 Reads

Mimickers of urothelial neoplasia.

Ann Diagn Pathol 2019 Feb 26;38:11-19. Epub 2018 Sep 26.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address:

Management of malignant urothelial tumors is often associated with extended costly treatments, some with significant morbidity. Advanced tumors are treated with radical cystectomy with neoadjuvant or adjuvant radiation or chemotherapy. Over and under interpretation of histological findings from biopsies and transurethral resections of urothelial lesions may either incur treatments with significant side effects or miss a possible window of cure, respectively. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.012DOI Listing
February 2019
5 Reads

FTO mRNA expression in the lower quartile is associated with bad prognosis in clear cell renal cell carcinoma based on TCGA data mining.

Ann Diagn Pathol 2019 Feb 25;38:1-5. Epub 2018 Oct 25.

Department of Urology, The Second Hospital of Dalian Medical University, Dalian, China. Electronic address:

Fat mass and obesity associated (FTO) is a protein-coding gene, also known as the obesity gene. It has been reported previously to be associated with a variety of malignant cancers, such as breast, thyroid and acute myeloid leukemia. The aim of the present study was to investigate the FTO mRNA expression in human clear cell renal cell carcinoma and its clinical value. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.009DOI Listing
February 2019
2 Reads

Subclassification of pleomorphic sarcomas: How and why should we care?

Authors:
Jason L Hornick

Ann Diagn Pathol 2018 Dec 11;37:118-124. Epub 2018 Oct 11.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

Pleomorphic sarcomas are a heterogeneous group of mesenchymal neoplasms with widely varied clinical behavior but overlapping histologic appearances. The following guidelines are helpful when approaching the diagnosis of a pleomorphic sarcoma. (1) Be aware of the relative incidence of the various sarcoma types: several pleomorphic sarcomas are relatively common (e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183032
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.006DOI Listing
December 2018
9 Reads

Intestinal T-cell and NK/T-cell lymphomas: A clinicopathological study of 27 Chinese patients.

Ann Diagn Pathol 2018 Dec 9;37:107-117. Epub 2018 Oct 9.

Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Electronic address:

Background: Intestinal T-cell and NK/T- cell lymphomas are rare and aggressive. The diagnosis is quite difficult, especial in biopsy specimens. This study investigates the clinicopathological features of intestinal T-cell and NK/T-cell lymphomas to aid their differential diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183013
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.004DOI Listing
December 2018
11 Reads
1.110 Impact Factor

Primary mediastinal melanotic schwannian tumors: A clinicopathological and immunohistochemical study of 5 cases.

Ann Diagn Pathol 2018 Dec 3;37:103-106. Epub 2018 Oct 3.

Department of Pathology of the University of Texas, MD Anderson Cancer Center, Houston, TX, United States of America.

Mediastinal neurogenic tumors are unusual and more so is the presence of melanotic neurogenic tumors. We present five cases of mediastinal melanotic neurogenic tumors. The patients are five men between the ages of 34 and 43 years (average: 38. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183031
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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.001DOI Listing
December 2018
12 Reads

Melanocytic lesions - Staying out of trouble.

Authors:
Thomas Brenn

Ann Diagn Pathol 2018 Dec 27;37:91-102. Epub 2018 Sep 27.

Department of Pathology & Laboratory Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; Department of Medicine, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary, AB T2L 2K8, Canada; The Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, 9 - 3535 Research Rd NW, Calgary AB T2L 2K8, Canada; Department of Pathology, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, United Kingdom. Electronic address:

The diagnosis of melanocytic tumors is notoriously difficult and represents one of the most challenging areas in surgical pathology associated with significant risk for litigation. One reason is the wide morphologic spectrum of melanocytic tumors and the fact that many histological features are shared by both benign melanocytic nevi and melanoma. Awareness of the many morphologic variations and variants of nevi and melanoma, their clinical setting, immunohistochemical phenotype and genetic profile is necessary for the correct diagnosis. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.010DOI Listing
December 2018
5 Reads

Nonalcoholic fatty liver disease (NAFLD): Diagnosis, pitfalls, and staging.

Ann Diagn Pathol 2018 Dec 27;37:83-90. Epub 2018 Sep 27.

Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, United States of America; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated with obesity, diabetes and the metabolic syndrome, not only in the Western societies, but also in most regions of the world in the 21st century. The spectrum of its histopathology ranges from steatosis to nonalcoholic steatohepatitis (NASH), with risk for progressive fibrosis that may lead to cirrhosis and hepatocellular carcinoma (HCC). Benign and malignant liver tumors have also been more frequently reported with the increasing prevalence of obesity and diabetes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183030
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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.009DOI Listing
December 2018
6 Reads

Some observations on Barrett esophagus and associated dysplasia.

Ann Diagn Pathol 2018 Dec 28;37:75-82. Epub 2018 Sep 28.

Department of Pathology, Cedars Sinai Health System, United States of America.

Biopsy samples from esophageal columnar metaplasia and dysplasia are commonly encountered in Western pathology practice and knowing a few pitfalls can save both pathologists and patients a great deal of anxiety. Herein we discuss criteria for Barrett esophagus, evaluation of dysplasia, and some pitfalls in reviewing endoscopic mucosal resections. Also included is a summary of suggested follow-up for patients with Barrett esophagus. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.013DOI Listing
December 2018
1 Read

Diagnostically relevant updates to the 2017 WHO classification of lymphoid neoplasms.

Ann Diagn Pathol 2018 Dec 27;37:67-74. Epub 2018 Sep 27.

Neogenomics Laboratories, Inc., Aliso Viejo, CA 92656, USA; M.D. Anderson Cancer Center, Houston, TX, USA. Electronic address:

The recent 2017 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues contains a number of updates under the category of lymphoid neoplasms. These changes include introduction of new entities, amended classification or terminology, and addition of newly discovered diagnostic and molecular features. In this review, we perform a focused, concise summary of selected lymphoid neoplasms and discuss changes in their classification. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.011DOI Listing
December 2018
3 Reads

Pediatric oral Epstein-Barr virus associated self-remitting CD30+ lymphoproliferative disorder: A distinct entity.

Ann Diagn Pathol 2018 Dec 12;37:57-61. Epub 2018 Sep 12.

Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:

Epstein-Barr virus (EBV) has a well-known association with lymphoproliferative disorders of B and T cell origin. EBV-related B cell lymphoproliferative disorders include Hodgkin and Burkitt lymphomas, lymphomatoid granulomatosis, EBV positive diffuse large cell B cell lymphoma of the elderly, as well as B cell lymphomas associated with solid organ transplantation and methotrexate use. EBV-related T cell disorders are primarily represented by NK/T- cell lymphoma. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.08.004DOI Listing
December 2018
7 Reads

Expression of the Annexin A1 and its correlation with matrix metalloproteinases and the receptor for formylated peptide-2 in diffuse astrocytic tumors.

Ann Diagn Pathol 2018 Dec 3;37:62-66. Epub 2018 Sep 3.

University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil; São Paulo State University, (UNESP), Institute of Biosciences, Humanities and Exact Sciences (Ibilce), São José do Rio Preto Campus, SP, Department of Biology, Laboratory of Immunomorphology, Brazil. Electronic address:

Astrocytomas represent the majority of cerebral gliomas. Studies show that the anti-inflammatory protein Annexin-A1 (ANXA1) is associated with the tumor invasion process and that its actions can be mediated by the receptor for formylated peptides (FPR). Therefore, we evaluated the expression of ANXA1, the receptor FPR2 and matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) in brain astrocytomas. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.08.002DOI Listing
December 2018
3 Reads

Cystic neutrophilic granulomatous mastitis: A clinicopathologic study of a distinct entity with supporting evidence of a role for Corynebacterium-targeted therapy.

Ann Diagn Pathol 2018 Dec 24;37:51-56. Epub 2018 Aug 24.

Department of Pathology and Laboratory Medicine, Western Connecticut Health Network, Danbury, CT, USA.

Cystic neutrophilic granulomatous mastitis (CNGM) is a distinct histopathologic entity characterized by neutrophilic and granulomatous inflammation surrounding clear cystic spaces. Rare gram-positive bacilli are sometimes identified within these cystic spaces. Studies in the literature have identified these gram-positive bacilli to be Corynebacterium species. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183020
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http://dx.doi.org/10.1016/j.anndiagpath.2018.08.005DOI Listing
December 2018
22 Reads

Analysis of clinical and pathological findings in inflammatory fibroid polyps of the gastrointestinal system: A series of 69 cases.

Ann Diagn Pathol 2018 12 12;37:47-50. Epub 2018 Sep 12.

Izmir Katip Celebi University, Ataturk Training and Research Hospital, Department of Pathology, Izmir, Turkey.

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.006DOI Listing
December 2018
2 Reads

Clinical presentation of ductal carcinoma in situ of breast with intraluminal crystalloids: Radiologic-histologic correlation.

Ann Diagn Pathol 2018 Dec 12;37:42-46. Epub 2018 Sep 12.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College, Cornell University, Houston, TX, United States of America. Electronic address:

Intraluminal crystalloids have rarely been described in the breast, particularly in cases with ductal carcinoma in situ (DCIS). We recently encountered a case of DCIS of the breast associated with numerous intraluminal crystalloids. The patient presented with a mass in the right breast, and microcalcifications were detected on screening and diagnostic mammograms; the patient underwent needle biopsies, lumpectomy, and skin-sparing mastectomy. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.001DOI Listing
December 2018
3 Reads

Laryngeal sarcomas: A case series of 5 cases.

Ann Diagn Pathol 2018 Dec 14;37:35-41. Epub 2018 Sep 14.

Pathology Section, Rashid Hospital, Dubai, United Arab Emirates.

Primary sarcomas of the larynx are rare and miscellaneous. The most common is chondrosarcoma. Other sarcomas are very rare. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.007DOI Listing
December 2018
2 Reads

The expression of TTF1, CDX2 and ISL1 in 74 poorly differentiated neuroendocrine carcinomas.

Ann Diagn Pathol 2018 Dec 13;37:30-34. Epub 2018 Sep 13.

Pathology, Penn State Hershey Medical Center, Hershey, PA, USA. Electronic address:

Background: The expression profile of immunohistochemical markers of origin in poorly differentiated neuroendocrine carcinoma (PDNEC) is not well studied.

Materials And Methods: Seventy-four PDNECs from gastroenteropancreatic (GEP) organs and the lung, including 48 large cell NEC (LCNEC) and 26 small cell carcinomas (SmCC), were subject to immunohistochemical staining for CDX2, TTF1 and ISL1. The staining intensity (1 to 3) and percentage of positive tumor cells [0 (negative), 1 (<50%) and 2 (≥50%)] were assessed. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.005DOI Listing
December 2018
14 Reads

Assessment of transurethral resection of the bladder specimens with pT1 high-grade urothelial carcinoma for the predictor features of muscularis propria invasion on radical cystectomy specimens.

Ann Diagn Pathol 2018 12 10;37:25-29. Epub 2018 Sep 10.

Urology Department, Istanbul Medeniyet University Goztepe Training and Research Hospital, Dr. Erkin Caddesi, Göztepe Egt. Ve Aras. Hastanesi Uroloji Klinigi, 34720 Kadıköy, Istanbul, Turkey.

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.003DOI Listing
December 2018
2 Reads

High-grade myoepithelial carcinoma can show histologically undifferentiated/anaplastic features.

Ann Diagn Pathol 2018 Dec 11;37:20-24. Epub 2018 Sep 11.

Department of Pathology, National University Health System, Singapore. Electronic address:

High grade malignant tumors with a poorly-/un-differentiated morphology pose significant diagnostic challenges. Increasingly, the use of adjunct immunohistochemical and molecular tests to characterize and delineate the histopathologic phenotype of these tumors has become necessary, particularly in head and neck tumors. Recently, several entities with a poorly-/un-differentiated light microscopic morphology have been defined based on specific immunohistochemical and genetic characteristics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183023
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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.004DOI Listing
December 2018
2 Reads