813 results match your criteria Annals of Clinical Microbiology and Antimicrobials[Journal]


Detection of carbapenemases bla-bla-bla-bla and extended-spectrum-β-lactamase bla-bla-bla genes in Gram-negative bacterial isolates from ICU burns patients.

Ann Clin Microbiol Antimicrob 2022 May 19;21(1):18. Epub 2022 May 19.

Institute of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan.

Background And Objectives: Burn patients are highly susceptible to invasion by multidrug-resistant Gram-negative bacteria (MDR-GNB) through post-burn damage. The prevalence of MDR-GNB isolated from burns patients has increased dramatically in the last decade, representing a serious risk to patients admitted to burns units worldwide. The challenges of managing infected burns patients are exacerbated in poor resource settings. Read More

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A fatal case of disseminated nocardiosis due to Nocardia otitidiscaviarum resistant to trimethoprim-sulfamethoxazole: case report and literature review.

Ann Clin Microbiol Antimicrob 2022 May 16;21(1):17. Epub 2022 May 16.

King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.

Background: Disseminated nocardiosis still causes significant morbidity and mortality and is often caused by Nocardia asteroides, N. basiliensis, and N. farcinica and are often treated with trimethoprim-sulfamethoxazole (TMP-SMX). Read More

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Successful use of dalbavancin in the treatment of gram positive blood stream infections: a case series.

Ann Clin Microbiol Antimicrob 2022 Apr 26;21(1):16. Epub 2022 Apr 26.

Prisma Health Upstate, 890 W Faris Road, Suite 520, Greenville, SC, 29605, USA.

Background: Dalbavancin is a semisynthetic antibiotic used as an alternative to vancomycin for skin infections and osteomyelitis. Its long half-life decreases length of hospitalizations. This study analyzes the effectiveness of Dalbavancin for bacteremia and infective endocarditis. Read More

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An unexpected case of Borrelia garinii liver infection.

Ann Clin Microbiol Antimicrob 2022 Mar 27;21(1):15. Epub 2022 Mar 27.

Centre Hospitalier Universitaire de Bordeaux, Laboratoire de Bactériologie, 33000, Bordeaux, France.

Background: Lyme borreliosis is the most prevalent arthropod-borne infection in the Northern Hemisphere. In Europe, Borrelia afzelii is predominantly involved in cutaneous manifestations, Borrelia garinii and Borrelia bavariensis in neurological manifestations, and Borrelia burgdorferi sensu stricto in articular ones. Liver impairement is not classical in Lyme borreliosis. Read More

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Vaccination of children against COVID-19: the experience in Latin America.

Ann Clin Microbiol Antimicrob 2022 03 25;21(1):14. Epub 2022 Mar 25.

Department of Infectious Diseases, VM Medicalpark Samsun Hospital, Samsun, Turkey.

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Antimicrobial activity of ceftazidime-avibactam and comparators against levofloxacin-resistant Escherichia coli collected from four geographic regions, 2012-2018.

Ann Clin Microbiol Antimicrob 2022 Mar 21;21(1):13. Epub 2022 Mar 21.

IHMA, Schaumburg, IL, USA.

Background: Increases in resistance to fluoroquinolones have been correlated with the use of levofloxacin in the treatment of infections caused by Escherichia coli. The analysis presents the in vitro activity of ceftazidime-avibactam and comparator agents against 10,840 levofloxacin-resistant E. coli isolates collected from four geographic regions (Africa/Middle East, Europe, Asia/South Pacific, Latin America) between 2012 and 2018. Read More

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Detection performance of PCR for Legionella pneumophila in environmental samples: a systematic review and meta-analysis.

Ann Clin Microbiol Antimicrob 2022 Mar 18;21(1):12. Epub 2022 Mar 18.

Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.

Background: Legionellosis remains a public health problem. The most common diagnostic method to detect Legionella pneumophila (L. pneumophila) is culture. Read More

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Diagnostic performance of RT-PCR-based sample pooling strategy for the detection of SARS-CoV-2.

Ann Clin Microbiol Antimicrob 2022 Mar 14;21(1):11. Epub 2022 Mar 14.

Facultad de Ciencias de la Salud, Universidad Científica del Sur, Lima, 15024, Peru.

Background: The rapid spread of SARS-CoV-2 has created a shortage of supplies of reagents for its detection throughout the world, especially in Latin America. The pooling of samples consists of combining individual patient samples in a block and analyzing the group as a particular sample. This strategy has been shown to reduce the burden of laboratory material and logistical resources by up to 80%. Read More

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VIM-encoding Inc plasmids and chromosome-borne integrative and mobilizable elements (IMEs) and integrative and conjugative elements (ICEs) in Pseudomonas.

Ann Clin Microbiol Antimicrob 2022 Mar 9;21(1):10. Epub 2022 Mar 9.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.

Background: The carbapenem-resistance genes bla are widely disseminated in Pseudomonas, and frequently harbored within class 1 integrons that reside within various mobile genetic elements (MGEs). However, there are few reports on detailed genetic dissection of bla-carrying MGEs in Pseudomonas.

Methods: This study presented the complete sequences of five bla-carrying MGEs, including two plasmids, two chromosomal integrative and mobilizable elements (IMEs), and one chromosomal integrative and conjugative element (ICE) from five different Pseudomonas isolates. Read More

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Olsenella uli-induced pneumonia: a case report.

Ann Clin Microbiol Antimicrob 2022 Mar 2;21(1). Epub 2022 Mar 2.

Department of Clinical Laboratory, the Affiliated Hospital of Qingdao University, 16 Jiangsu Road, 266000, Qingdao, China.

Background: Olsenella uli is anaerobic or microaerophilic bacteria, commonly found in oral cavity or gastrointestinal tract, which has not been reported to be associated with lower respiratory tract infection. Herein, we report the first case of Olsenella uli infection in the lung.

Case Presentation: A 70-year-old male farmer with no history of other respiratory tract diseases developed a cough with bloody sputum three times a day without obvious causes or other concomitant symptoms. Read More

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Effective anti-mycobacterial treatment for BCG disease in patients with Mendelian Susceptibility to Mycobacterial Disease (MSMD): a case series.

Ann Clin Microbiol Antimicrob 2022 Mar 1;21(1). Epub 2022 Mar 1.

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Post-vaccination BCG disease typically attests to underlying inborn errors of immunity (IEIs), with the highest rates of complications in patients with Mendelian susceptibility to mycobacterial disease (MSMD). However, therapeutic protocols for the management of BCG-osis (disseminated) and persistent BCG-itis (localized) are still controversial.

Methods: Twenty-four Iranian patients with MSMD (BCG-osis or BCG-itis), followed from 2009 to 2020 in Tehran, were included in the study. Read More

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Correlation of clinical sepsis definitions with microbiological characteristics in patients admitted through a sepsis alert system; a prospective cohort study.

Ann Clin Microbiol Antimicrob 2022 Feb 22;21(1). Epub 2022 Feb 22.

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.

Background: Sepsis was recently redefined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. With this redefinition (Sepsis-3), clinical and microbiological characteristics of patients with sepsis may differ from the patients fulfilling the previous definition (Sepsis-2).

Purpose: To describe differences in clinical and microbiological characteristics of sepsis episodes between Sepsis-3 and Sepsis-2. Read More

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February 2022

Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern.

Ann Clin Microbiol Antimicrob 2022 Feb 16;21(1). Epub 2022 Feb 16.

Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nosocomial infections (NIs) could lead to considerably higher mortality rates, length of the hospital stays and costs, and represent a serious public health concern worldwide. Besides, the unreasonable use of antibiotics could lead to get resistant to different antibiotics and create limited therapeutic options, increased risks of treatment failure and poor patient management. The current study aimed to evaluate the prevalence and antimicrobial susceptibility of NIs in an Iranian referral pediatrics hospital during 3 years. Read More

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February 2022

Protothecosis in the mucosa of the pharynx mimicking pharyngeal cancer in an immunocompetent individual: a case report.

Ann Clin Microbiol Antimicrob 2022 Feb 14;21(1). Epub 2022 Feb 14.

Department of Infectious Diseases, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Protothecosis is a rare infection in humans and animals caused by the achlorophyllic algae Prototheca species. More than half of the protothecosis cases are cutaneous infections, and most cases are observed in immunocompromised individuals.

Case Presentation: We report a case of Prototheca wickerhamii infection in the mucosa of the pharynx in a 53-year-old immunocompetent woman with an incidentally found mass lesion at the left tongue base. Read More

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February 2022

Facklamia hominis pyelonephritis in a pediatric patient: first case report and review of the literature.

Ann Clin Microbiol Antimicrob 2022 Feb 12;21(1). Epub 2022 Feb 12.

Department of Pediatrics / Infectious Diseases Service, Hospital Universitario "Dr. José Eleuterio González" Universidad Autónoma de Nuevo León, Francisco I. Madero Avenue, Mitras Centro, ZC, 64460, Monterrey, Mexico.

Background: Pyelonephritis is one of the most serious bacterial illnesses during childhood. Gram-negative organisms account for up to 90% of the cases. Gram-positive bacteria are uncommon causes of urinary tract infections, and only a few cases caused by Facklamia hominis have been reported in the literature. Read More

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February 2022

Population snapshot of the extended-spectrum β-lactamase-producing Escherichia coli invasive strains isolated from a Hungarian hospital.

Ann Clin Microbiol Antimicrob 2022 Feb 10;21(1). Epub 2022 Feb 10.

Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.

Background: This study was carried out to determine the prevalence and the genetic background of extended-spectrum β-lactamase-producing Escherichia coli invasive isolates obtained from a tertiary-care hospital in Budapest, Hungary.

Methods: Between October-November 2018, all invasive ESBL-producing E. coli isolates were collected from Central Hospital of Southern Pest. Read More

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February 2022

Genomic insights into virulence factors affecting tissue-invasive Klebsiella pneumoniae infection.

Ann Clin Microbiol Antimicrob 2022 Feb 5;21(1). Epub 2022 Feb 5.

Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.

Background: The key virulence factors responsible for hypervirulent Klebsiella pneumoniae (hvKp) infection remains elusive.

Methods: We analyzed K. pneumoniae isolates collected between 2017 and 2019 and defined hvKp as a pyogenic infection. Read More

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February 2022

The characteristic and potential therapeutic effect of isolated multidrug-resistant Acinetobacter baumannii lytic phage.

Ann Clin Microbiol Antimicrob 2022 Jan 7;21(1). Epub 2022 Jan 7.

Department of Bacteriology and Virology, Faculty of Medicine, Isfahan University of Medical Sciences, 81744-176, Isfahan, Iran.

Background: Widespread misuse of antibiotics caused bacterial resistance increasingly become a serious threat. Bacteriophage therapy promises alternative treatment strategies for combatting drug-resistant bacterial infections. In this study, we isolated and characterized a novel, potent lytic bacteriophage against multi-drug resistant (MDR) Acinetobacter baumannii and described the lytic capability and endolysin activity of the phage to evaluate the potential in phage therapy. Read More

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January 2022

Severe polymicrobial and fungal periprosthetic osteomyelitis persisting after hip disarticulations treated with caspofungin in risk patients: a case series.

Ann Clin Microbiol Antimicrob 2021 Dec 31;20(1):86. Epub 2021 Dec 31.

Orthopedic Clinic and Policlinic, University Medical Center Rostock, Doberaner Str. 142, 18057, Rostock, Germany.

Background: Periprosthetic fungal infections are considered rare and opportunistic infections. Treatment is difficult, and established standards do not yet exist. The choice of the appropriate antifungal drug might affect the patient outcome. Read More

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December 2021

Persistent SARS-CoV-2 infection in patients with secondary antibody deficiency: successful clearance following combination casirivimab and imdevimab (REGN-COV2) monoclonal antibody therapy.

Ann Clin Microbiol Antimicrob 2021 Dec 30;20(1):85. Epub 2021 Dec 30.

Department of Infectious Diseases and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Background: There is growing evidence that antibody responses play a role in the resolution of SARS-CoV-2 infection. Patients with primary or secondary antibody deficiency are at increased risk of persistent infection. This challenging clinical scenario is associated with adverse patient outcome and potentially creates an ecological niche for the evolution of novel SARS-CoV-2 variants with immune evasion capacity. Read More

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December 2021

Epidemiological profile of multidrug-resistant and extensively drug-resistant Mycobacterium Tubrculosis among Congolese patients.

Ann Clin Microbiol Antimicrob 2021 Dec 17;20(1):84. Epub 2021 Dec 17.

Fondation Congolaise pour la Recherche Médicale, Villa D6, Campus OMS, Djoué, Brazzaville, Republic of Congo.

Background: There is paucity of data on the prevalence and distribution of multidrug- Resistant-Tuberculosis (MDR-TB) in the Republic of Congo. Among the challenges resides the implementation of a robust TB resistance diagnostic program using molecular tools. In resource limited settings there is a need to gather data to enable prioritization of actions. Read More

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December 2021

Successful treatment of a kidney transplant patient with COVID-19 and late-onset Pneumocystis jirovecii pneumonia.

Ann Clin Microbiol Antimicrob 2021 Dec 15;20(1):83. Epub 2021 Dec 15.

Department of Pediatrics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.

Background: Solid transplant patients are susceptible to Pneumocystis jirovecii pneumonia (PJP). While the vast majority of PJP cases occur within the first 6 months after transplantation, very few PJP cases are seen beyond 1 year post-transplantation (late-onset PJP). PJP and coronavirus disease 2019 (COVID-19, caused by infection with SARS-CoV-2) share quite a few common clinical manifestations and imaging findings, making the diagnosis of PJP often underappreciated during the current COVID-19 pandemic. Read More

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December 2021

Correction to: Molecular characterization of NDM-1-producing Pseudomonas aeruginosa isolates from hospitalized patients in Iran.

Ann Clin Microbiol Antimicrob 2021 Dec 11;20(1):82. Epub 2021 Dec 11.

Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

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December 2021

Rapid detection of a novel B1-β-lactamase gene, blaAFM-1 using a loop-mediated isothermal amplification (LAMP) assay.

Ann Clin Microbiol Antimicrob 2021 Dec 7;20(1):80. Epub 2021 Dec 7.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Background: BlaAFM-1 (GenBank Accession No. 143105.1) is a new B1 subclass metallo-β-lactamase gene discovered by our group, and isolated from an Alcaligenes faecalis plasmid that renders carbapenem antibiotics ineffective. Read More

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December 2021

The molecular mechanisms of fluoroquinolone resistance found in rectal swab isolates of Enterobacterales from men undergoing a transrectal prostate biopsy: the rationale for targeted prophylaxis.

Ann Clin Microbiol Antimicrob 2021 Dec 7;20(1):81. Epub 2021 Dec 7.

Department of Bacteriology, National Institute of Public Health NIH - National Research Institute, Chocimska 24, 00-791, Warsaw, Poland.

Background: Transrectal ultrasound-guided prostate biopsy (TRUS-Bx) is considered an essential urological procedure for the histological diagnosis of prostate cancer. It is, however, considered a "contaminated" procedure which may lead to infectious complications. Recent studies suggest a significant share of fluoroquinolone-resistant rectal flora in post-biopsy infections. Read More

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December 2021

Antibiotic resistance modifying ability of phytoextracts in anthrax biological agent Bacillus anthracis and emerging superbugs: a review of synergistic mechanisms.

Ann Clin Microbiol Antimicrob 2021 Dec 2;20(1):79. Epub 2021 Dec 2.

Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.

Background And Objectives: The chemotherapeutic management of infections has become challenging due to the global emergence of antibiotic resistant pathogenic bacteria. The recent expansion of studies on plant-derived natural products has lead to the discovery of a plethora of phytochemicals with the potential to combat bacterial drug resistance via various mechanisms of action. This review paper summarizes the primary antibiotic resistance mechanisms of bacteria and also discusses the antibiotic-potentiating ability of phytoextracts and various classes of isolated phytochemicals in reversing antibiotic resistance in anthrax agent Bacillus anthracis and emerging superbug bacteria. Read More

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December 2021

Epidemiology, mortality and effectiveness of prophylaxis for Pneumocystis jiroveci pneumonia among rheumatic patients: a territory-wide study.

Ann Clin Microbiol Antimicrob 2021 Nov 11;20(1):78. Epub 2021 Nov 11.

Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

Background: Pneumocystis jiroveci pneumonia (PJP) is an opportunistic infection affecting immunocompromised individuals. However, evidence regarding the burden and effectiveness of prophylaxis among rheumatic patients remains limited. Delineating the epidemiology and efficacy of prophylaxis among rheumatic patients is urgently needed. Read More

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November 2021

Differences of virulence factors, and antimicrobial susceptibility according to phylogenetic group in uropathogenic Escherichia coli strains isolated from Korean patients.

Ann Clin Microbiol Antimicrob 2021 Nov 10;20(1):77. Epub 2021 Nov 10.

Department of Infectious Diseases, Keimyung University School of Medicine, 1095 Dalgubeol-daero, Dalseo-gu, Daegu, 42601, Republic of Korea.

Background: Escherichia coli is among the most common uropathogens. Increased antibiotic resistance in Gram negative bacilli is global concern. Alternative therapeutic options including vaccines against uropathogenic E. Read More

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November 2021

Molecular characterization of NDM-1-producing Pseudomonas aeruginosa isolates from hospitalized patients in Iran.

Ann Clin Microbiol Antimicrob 2021 Nov 3;20(1):76. Epub 2021 Nov 3.

Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: The emergence of carbapenem-resistant Pseudomonas aeruginosa is one of the most important challenges in a healthcare setting. The aim of this study is double-locus sequence typing (DLST) typing of bla positive P. aeruginosa isolates. Read More

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November 2021

Prevalence of β-lactamase-encoding genes and molecular typing of Acinetobacter baumannii isolates carrying carbapenemase OXA-24 in children.

Ann Clin Microbiol Antimicrob 2021 Oct 26;20(1):75. Epub 2021 Oct 26.

Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Background: β-Lactam antibiotics have been broadly used for the treatment of Acinetobacter baumannii infections, resulting in development of β-lactam inactivating β-lactamases. Here, we described antibiotic resistance rate, prevalence of β-lactamase-encoding genes, and clonal relationships of A. baumannii strains isolated from children referred to Children's Medical Center in Tehran, Iran, during 2019-2020. Read More

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October 2021