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    556 results match your criteria Annals of Clinical Microbiology and Antimicrobials[Journal]

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    Molecular characterization of β-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii.
    Ann Clin Microbiol Antimicrob 2017 Nov 16;16(1):75. Epub 2017 Nov 16.
    Center for Surgical Infections & Biofilms, Institute of Molecular Medicine and Infectious diseases, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA.
    Background: Acinetobacter baumannii is a nosocomial pathogen which is establishing as a major cause of morbidity and mortality within the healthcare community. The success of this pathogen is largely due to its ability to rapidly gain resistance to antimicrobial therapies and its capability to persist in an abiotic environment through the production of a biofilm. Our tertiary-care hospital has showed high incidence of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. Read More

    Herpes simplex virus-1 entrapped in Candida albicans biofilm displays decreased sensitivity to antivirals and UVA1 laser treatment.
    Ann Clin Microbiol Antimicrob 2017 Nov 14;16(1):72. Epub 2017 Nov 14.
    Department of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Via del Pozzo 87, 41125, Modena, Italy.
    Background: Recently, we published data suggesting a mutualistic relationship between HSV-1 and Candida. albicans; in particular: (a) HSV-1 infected macrophages are inhibited in their anti-Candida effector function and (b) Candida biofilm protects HSV-1 from inactivation. The present in vitro study is aimed at testing the effects of Candida biofilm on HSV-1 sensitivity to pharmacological and physical stress, such as antiviral drugs (acyclovir and foscarnet) and laser UVA1 irradiation. Read More

    New eight genes identified at the clinical multidrug-resistant Acinetobacter baumannii DMS06669 strain in a Vietnam hospital.
    Ann Clin Microbiol Antimicrob 2017 Nov 14;16(1):74. Epub 2017 Nov 14.
    Department of Biotechnology, Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, HCM National University, Ho Chi Minh City, Vietnam.
    Background: Acinetobacter baumannii is an important nosocomial pathogen that can develop multidrug resistance. In this study, we characterized the genome of the A. baumannii strain DMS06669 (isolated from the sputum of a male patient with hospital-acquired pneumonia) and focused on identification of genes relevant to antibiotic resistance. Read More

    Prevalence of current patterns and predictive trends of multidrug-resistant Salmonella Typhi in Sudan.
    Ann Clin Microbiol Antimicrob 2017 Nov 14;16(1):73. Epub 2017 Nov 14.
    Faculty of Science, University of Khartoum, Khartoum, Sudan.
    Background: Enteric fever has persistence of great impact in Sudanese public health especially during rainy season when the causative agent Salmonella enterica serovar Typhi possesses pan endemic patterns in most regions of Sudan - Khartoum.

    Objectives: The present study aims to assess the recent state of antibiotics susceptibility of Salmonella Typhi with special concern to multidrug resistance strains and predict the emergence of new resistant patterns and outbreaks.

    Methods: Salmonella Typhi strains were isolated and identified according to the guidelines of the International Standardization Organization and the World Health Organization. Read More

    Intensive care antibiotic consumption and resistance patterns: a cross-correlation analysis.
    Ann Clin Microbiol Antimicrob 2017 Nov 13;16(1):71. Epub 2017 Nov 13.
    Microbiology Department, "Victor Babes" University of Medicine and Pharmacy, 16 Victor Babes, Timisoara, Romania.
    Background: Over recent decades, a dramatic increase in infections caused by multidrug-resistant pathogens has been observed worldwide. The aim of the present study was to investigate the relationship between local resistance bacterial patterns and antibiotic consumption in an intensive care unit in a Romanian university hospital.

    Methods: A prospective study was conducted between 1st January 2012 and 31st December 2013. Read More

    Biofilm and metallo beta-lactamase production among the strains of Pseudomonas aeruginosa and Acinetobacter spp. at a Tertiary Care Hospital in Kathmandu, Nepal.
    Ann Clin Microbiol Antimicrob 2017 Nov 2;16(1):70. Epub 2017 Nov 2.
    Department of Microbiology, Nepalese Army Institute of Health Sciences, Syanobharyang, Kathmandu, Nepal.
    Introduction: Pseudomonas aeruginosa and Acinetobacter spp. are found to be associated with biofilm and metallo-β-lactamase production and are the common causes of serious infections mainly in hospitalized patients. So, the main aims of this study were to determine the rates of biofilm production and metallo beta-lactamase production (MBL) among the strains of Pseudomonas aeruginosa and Acinetobacter spp. Read More

    Benzoylphenyl thiocyanates are new, effective inhibitors of the mycobacterial resuscitation promoting factor B protein.
    Ann Clin Microbiol Antimicrob 2017 Nov 2;16(1):69. Epub 2017 Nov 2.
    Laboratory of Biochemistry of Stress in Microorganisms, A.N. Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Leninsky prospect, 33 (2), Moscow, 119071, Russia.
    Background: Resuscitation promoting factors (Rpfs) are the proteins involved in the process of reactivation of the dormant cells of mycobacteria. Recently a new class of nitrophenylthiocyanates (NPTs), capable of inhibiting the biological and enzymatic activities of Rpfs has been discovered. In the current study the inhibitory properties of the compounds containing both nitro and thiocyanate groups alongside with the compounds with the modified number and different spatial location of the substituents are compared. Read More

    Spondylodiskitis and endocarditis due to Streptococcus gordonii.
    Ann Clin Microbiol Antimicrob 2017 Oct 4;16(1):68. Epub 2017 Oct 4.
    Department of Internal Medicine C, Shaare Zedek Medical Medicine, Affiliated with the Hebrew University-Hadassah Medical School, Jerusalem, Israel.
    Background: Streptococcus gordonii is an infrequent cause of infective endocarditis (IE); associated spondylodiskitis has not yet been described in the literature.

    Purpose: We describe 2 patients who presented with new-onset, severe back pain; blood cultures revealed S. gordonii bacteremia, which led to the diagnosis of spondylodiskitis and IE. Read More

    Treating tuberculosis with high doses of anti-TB drugs: mechanisms and outcomes.
    Ann Clin Microbiol Antimicrob 2017 Oct 3;16(1):67. Epub 2017 Oct 3.
    National Tuberculosis Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, 9 Beiguan Street, Tongzhou District, Beijing, 101149, China.
    Tuberculosis (TB) is considered as one of the most serious threats to public health in many parts of the world. The threat is even more severe in the developing countries where there is a lack of advanced medical amenities and contemporary anti-TB drugs. In such situations, dosage optimization of existing medication regimens seems to be the only viable option. Read More

    Evaluation of lytic bacteriophages for control of multidrug-resistant Salmonella Typhimurium.
    Ann Clin Microbiol Antimicrob 2017 Sep 22;16(1):66. Epub 2017 Sep 22.
    Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea.
    Background: The emergence of antibiotic-resistant bacteria can cause serious clinical and public health problems. This study describes the possibility of using bacteriophages as an alternative agent to control multidrug-resistant Salmonella Typhimurium.

    Methods: The potential lytic bacteriophages (P22-B1, P22, PBST10, PBST13, PBST32, and PBST 35) were characterized by morphological property, heat and pH stability, optimum multiplicity of infection (MOI), and lytic activity against S. Read More

    Coagulase gene polymorphism, enterotoxigenecity, biofilm production, and antibiotic resistance in Staphylococcus aureus isolated from bovine raw milk in North West India.
    Ann Clin Microbiol Antimicrob 2017 Sep 20;16(1):65. Epub 2017 Sep 20.
    Sawai Man Singh Medical College, Jaipur, 302004, Rajasthan, India.
    Background: Staphylococcus aureus is the predominant bacterium responsible for various diseases in animals and humans. Preventive strategies could be better implemented by understanding the prevalence, genetic patterns, and the presence of enterotoxin and biofilm-producing genes along with the antibiotic susceptibility of this organism. This study was conducted in Rajasthan, the northwestern state of India, holding the largest population of cattle that makes it the second largest milk producer in India and no such prior information is available on these aspects. Read More

    Extended spectrum beta-lactamase and metallo beta-lactamase production among Escherichia coli and Klebsiella pneumoniae isolated from different clinical samples in a tertiary care hospital in Kathmandu, Nepal.
    Ann Clin Microbiol Antimicrob 2017 Sep 19;16(1):62. Epub 2017 Sep 19.
    Department of Laboratory Medicine, OM Hospital and Research Center, Chabahil, Kathmandu, Nepal.
    Background: Extended spectrum beta-lactamase (ESBL) and metallo beta-lactamase (MBL) production in Klebsiella pneumoniae and Escherichia coli are the commonest modes of drug resistance among these commonly isolated bacteria from clinical specimens. So the main purpose of our study was to determine the burden of ESBL and MBL production in E. coli and K. Read More

    Vancomycin heteroresistance in coagulase negative Staphylococcus blood stream infections from patients of intensive care units in Mansoura University Hospitals, Egypt.
    Ann Clin Microbiol Antimicrob 2017 Sep 19;16(1):63. Epub 2017 Sep 19.
    Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
    Background: Vancomycin heteroresistance in coagulase negative Staphylococci (CoNS) is a recent health concern especially in serious infections like bloodstream infections as it may lead to failure of therapy. Little information is available about the prevalence vancomycin heteroresistance in CoNS causing bloodstream infections in intensive care units (ICUs) patients of Mansoura University Hospitals (MUHs).

    Methods: This prospective study enrolled 743 blood samples collected from ICUs patients presented with clinical manifestations of bloodstream infections over the period extending from January 2014 to March 2016. Read More

    Paramedical staffs knowledge and attitudes towards antimicrobial resistance in Dire Dawa, Ethiopia: a cross sectional study.
    Ann Clin Microbiol Antimicrob 2017 Sep 19;16(1):64. Epub 2017 Sep 19.
    School of Medicine, College of Medicine and Health Sciences, Dire Dawa University, Dire Dawa, Ethiopia.
    Background: The continuing emergence, development and spread of pathogenic organisms that are resistant to antimicrobials are a cause of increasing concern. The control of antimicrobial resistance requires knowledge of factors causing antimicrobial resistance, good attitudes towards the intervention strategies as well as changes in antibiotic prescribing behavior of health workers. Hence, this study was aimed to assess paramedical staffs' knowledge and attitudes towards antimicrobial resistance and their antibiotics prescription practices in Dire Dawa, Ethiopia. Read More

    A childhood-onset intestinal toxemia botulism during chemotherapy for relapsed acute leukemia.
    Ann Clin Microbiol Antimicrob 2017 Sep 18;16(1):61. Epub 2017 Sep 18.
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    Background: Botulism is a potentially fatal infection characterized by progressive muscle weakness, bulbar paralysis, constipation and other autonomic dysfunctions. A recent report suggested that cancer chemotherapy might increase the risk for the intestinal toxemia botulism in both adults and children.

    Case Presentation: We report a 5-year-old boy, who developed general muscle weakness, constipation, ptosis and mydriasis during the third induction therapy for relapsed acute myeloid leukemia. Read More

    Voriconazole and posaconazole therapeutic drug monitoring: a retrospective study.
    Ann Clin Microbiol Antimicrob 2017 Sep 11;16(1):60. Epub 2017 Sep 11.
    Department of Clinical Pharmacy, University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, 12850 E Montview Blvd, Aurora, CO, 80045, USA.
    Background: Therapeutic drug monitoring (TDM) aims to minimize the clinical impact of posaconazole and voriconazole pharmacokinetic variability. However, its benefits on clinical outcomes are still being defined. Additionally, TDM data are limited for posaconazole IV and delayed-release tablet formulations among specific patient populations, including critically ill. Read More

    Diagnostic testing for Legionnaires' disease.
    Ann Clin Microbiol Antimicrob 2017 Aug 29;16(1):59. Epub 2017 Aug 29.
    Special Pathogens Laboratory, 1401 Forbes Avenue, Pittsburgh, PA, 15219, USA.
    Legionnaires' disease is commonly diagnosed clinically using a urinary antigen test. The urinary antigen test is highly accurate for L. pneumophila serogroup 1, however other diagnostic tests should also be utilized in conjunction with the urinary antigen as many other Legionella species and serogroups are pathogenic. Read More

    Transmission and characterization of bla NDM-1 in Enterobacter cloacae at a teaching hospital in Yunnan, China.
    Ann Clin Microbiol Antimicrob 2017 Aug 22;16(1):58. Epub 2017 Aug 22.
    Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Laboratory Diagnosis, Yunnan Key Laboratory of Laboratory Medicine, No. 295, Xichang Road, Wuhua, Kunming, Yunnan, China.
    Background: In recent years, New Delhi metallo-beta-lactamases 1 (bla NDM-1) has been reported with increasing frequency and become prevalent. The present study was undertaken to investigate the epidemiological dissemination of the bla NDM-1 gene in Enterobacter cloacae isolates at a teaching hospital in Yunnan, China.

    Methods: Antimicrobial susceptibility testing was performed using VITEK 2 system and E test gradient strips. Read More

    Extreme diversity and multiple SCCmec elements in coagulase-negative Staphylococcus found in the Clinic and Community in Beijing, China.
    Ann Clin Microbiol Antimicrob 2017 Aug 22;16(1):57. Epub 2017 Aug 22.
    State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
    Background: Coagulase-negative staphylococci (CoNS) are recognized as a large reservoir of staphylococcal cassette chromosome mec (SCCmec) harboured by Staphylococcus aureus. However, data of SCCmec in CoNS are relatively absent particularly in China.

    Methods: Seventy-eight CoNS clinical and 47 community isolates were collected in Beijing. Read More

    PknB remains an essential and a conserved target for drug development in susceptible and MDR strains of M. Tuberculosis.
    Ann Clin Microbiol Antimicrob 2017 Aug 18;16(1):56. Epub 2017 Aug 18.
    Department of Molecular Biology, National AIDS Research Institute, 73 G MIDC, Bhosari, Pune, 411 026, India.
    Background: The Mycobacterium tuberculosis (M.tb) protein kinase B (PknB) which is now proved to be essential for the growth and survival of M.tb, is a transmembrane protein with a potential to be a good drug target. Read More

    Molecular determination of antimicrobial resistance in Escherichia coli isolated from raw meat in Addis Ababa and Bishoftu, Ethiopia.
    Ann Clin Microbiol Antimicrob 2017 Aug 15;16(1):55. Epub 2017 Aug 15.
    Ethiopian Institute of Agricultural Research, National Agricultural Biotechnology Research Center, P.O.Box 31, Holeta, Ethiopia.
    Background: Consumption of meat contaminated by E. coli causes a serious illness and even death to affected individuals. Recently the emerging of antibiotic resistant foodborne E. Read More

    Second-line therapy for Helicobacter pylori eradication causing antibiotic-associated hemorrhagic colitis.
    Ann Clin Microbiol Antimicrob 2017 Aug 14;16(1):54. Epub 2017 Aug 14.
    Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan.
    Objective: Helicobacter pylori (H. pylori) eradication rarely develops into antibiotic-associated hemorrhagic colitis (AAHC), in which the etiology of colitis remains unclear. We herein report a rare case of AAHC caused by second-line therapy for H. Read More

    An assessment on the role of endophytic microbes in the therapeutic potential of Fagonia indica.
    Ann Clin Microbiol Antimicrob 2017 Aug 1;16(1):53. Epub 2017 Aug 1.
    Molecular Systematics and Applied Ethno Botany Lab (MoSEL), Department of Biotechnology, Quaid I Azam University, Islamabad, Pakistan.
    Background: Natural products of animals, plants and microbes are potential source of important chemical compounds, with diverse applications including therapeutics. Endophytic bacteria that are especially associated with medicinal plants presents a reservoir of therapeutic compounds. Fagonia indica has been recently investigated by numerous researchers because of its striking therapeutic potential especially in cancer. Read More

    Influence of borderline cefepime MIC on the outcome of cefepime-susceptible Pseudomonas aeruginosa bacteremia treated with a maximal cefepime dose: a hospital-based retrospective study.
    Ann Clin Microbiol Antimicrob 2017 Jul 24;16(1):52. Epub 2017 Jul 24.
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, 5 Fu-Shin Street, Gueishan 333, Taoyuan, Taiwan.
    Background: We assessed the influence of current cefepime minimal inhibitory concentration (MIC) breakpoints and the maximal cefepime dose on treatment outcomes in patients with bacteremia caused by cefepime-susceptible Pseudomonas aeruginosa.

    Methods: Adult patients hospitalized between July 2010 and June 2014 with a positive blood culture for cefepime-susceptible P. aeruginosa and receipt of cefepime as the primary therapy throughout the course were reviewed. Read More

    Molecular characterization and genetic relatedness of clinically Acinetobacter baumanii isolates conferring increased resistance to the first and second generations of tetracyclines in Iran.
    Ann Clin Microbiol Antimicrob 2017 Jul 19;16(1):51. Epub 2017 Jul 19.
    Antimicrobial Resistance Research Center, Bu Ali Research Institute, Mashhad, Iran.
    Background: The increasing resistance of Acinetobacter baumannii to antibiotics has recently been regarded as a notable therapeutic difficulty. Evaluating resistance rates of some A. baumannii isolates to tetracyclines had an impact on understanding the antibiotic resistance dissemination. Read More

    Antimicrobial susceptibility among Gram-positive and Gram-negative organisms collected from the Latin American region between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial.
    Ann Clin Microbiol Antimicrob 2017 Jul 12;16(1):50. Epub 2017 Jul 12.
    Pfizer Inc, Collegeville, PA, 19426, USA.
    Background: The in vitro activity of tigecycline and comparator agents was evaluated against Gram-positive and Gram-negative isolates collected in Latin American centers between 2004 and 2015 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S. Read More

    Prevalence of multi drug resistant enteropathogenic and enteroinvasive Escherichia coli isolated from children with and without diarrhea in Northeast Indian population.
    Ann Clin Microbiol Antimicrob 2017 Jul 11;16(1):49. Epub 2017 Jul 11.
    Department of MLT, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, India.
    Background: Diarrheagenic Escherichia coli are associated with infantile diarrhea in the developing countries. The present study was conducted to determine the occurrence and antimicrobial resistance pattern of enteropathogenic and enteroinvasive E. coli associated with diarrhoea among the paediatric patients. Read More

    Comparison of in-house and commercial real time-PCR based carbapenemase gene detection methods in Enterobacteriaceae and non-fermenting gram-negative bacterial isolates.
    Ann Clin Microbiol Antimicrob 2017 Jul 10;16(1):48. Epub 2017 Jul 10.
    Center for Clinical and Translational Research, Institute for Medical Laboratory Diagnostics, HELIOS University Clinic Wuppertal; Witten/Herdecke University, Heusnerstr. 40, 42283, Wuppertal, Germany.
    Background: Carbapenemase-producing gram-negative bacteria are increasing globally and have been associated with outbreaks in hospital settings. Thus, the accurate detection of these bacteria in infections is mandatory for administering the adequate therapy and infection control measures. This study aimed to establish and evaluate a multiplex real-time PCR assay for the simultaneous detection of carbapenemase gene variants in gram-negative rods and to compare the performance with a commercial RT-PCR assay (Check-Direct CPE). Read More

    Parasitological and biochemical studies on cutaneous leishmaniasis in Shara'b District, Taiz, Yemen.
    Ann Clin Microbiol Antimicrob 2017 Jul 4;16(1):47. Epub 2017 Jul 4.
    College of Engineering, Sinnar University, Sinnar, Sudan.
    Background: The leishmaniasis is a group of diseases caused by intracellular haemoflagellate protozoan parasites of the genus Leishmania. Leishmaniasis has diverse clinical manifestations; cutaneous leishmaniasis (CL) is the most common form of leishmaniasis which is responsible for 60% of disability-adjusted life years. CL is endemic in Yemen. Read More

    Profiling of antibiotic resistance of bacterial species recovered from routine clinical isolates in Ethiopia.
    Ann Clin Microbiol Antimicrob 2017 Jun 26;16(1):46. Epub 2017 Jun 26.
    International Clinical Laboratories, Addis Ababa, Ethiopia.
    Background: With the alarming rise in antibiotic resistance in African countries, the need for a surveillance system in the region has become pressing. The rapid expansion of data networks makes it possible to set up healthcare applications that can be both cost-efficient and effective. Large data sets are available for assessment of current antibiotic resistance among Ethiopian patients. Read More

    Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Ureaplasma urealyticum infections using a novel isothermal simultaneous RNA amplification testing method in infertile males.
    Ann Clin Microbiol Antimicrob 2017 Jun 24;16(1):45. Epub 2017 Jun 24.
    Departments of Reproductive Medicine, Urology, and Nursing, The First Affiliated Hospital of Wenzhou Medical University, #2-4P07 Nan Bai Xiang, Ouhai, Wenzhou, 325000, Zhejiang, China.
    Background: The purpose of this study was to evaluate the prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Ureaplasma urealyticum infections in infertile men that consulted our outpatient departments using a novel simultaneous amplification testing (SAT) that is RNA-detection based. The possible impact of C. trachomatis, N. Read More

    Molecular characterization of clinical IMP-producing Klebsiella pneumoniae isolates from a Chinese Tertiary Hospital.
    Ann Clin Microbiol Antimicrob 2017 Jun 19;16(1):42. Epub 2017 Jun 19.
    Department of Microbiology, Chinese PLA General Hospital, 301 Hospital, 28# Fuxing Road, Beijing, 100853, China.
    Background: IMP-producing Klebsiella pneumoniae (IMPKpn) exhibits sporadic prevalence in China. The mechanisms related to the spread of IMPKpn remain unclear.

    Methods: Carbapenem non-susceptible K. Read More

    Tuberculosis arthritis of the sternoclavicular joint after uncomplicated falciparum malaria: a case report.
    Ann Clin Microbiol Antimicrob 2017 Jun 5;16(1):44. Epub 2017 Jun 5.
    Service de Médecine Interne, Hôpital Aristide Le Dantec, Université Cheikh Anta Diop de Dakar, Avenue Cheikh Anta Diop, Fann, BP 5005, Dakar, Senegal.
    Background: Malaria and tuberculosis are co-endemic in many developing countries. However their associations are rarely reported. Yet, it has been suggested that a pathological process may link the two diseases. Read More

    Effect of the 2014 Clinical and Laboratory Standards Institute urine-specific breakpoints on cefazolin susceptibility rates at a community teaching hospital.
    Ann Clin Microbiol Antimicrob 2017 May 30;16(1):43. Epub 2017 May 30.
    University of Georgia College of Pharmacy, 1000 Jefferson Street, Albany, GA, 31701, USA.
    Background: Enterobacteriaceae, which include Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, are identified as the infectious etiology in the majority of urinary tract infections (UTIs) in community hospitals across the United States. The minimum inhibitory concentration (MIC) is a useful tool when choosing an appropriate antibacterial agent. Recent changes to the 2014 Clinical and Laboratory Standards Institute (CLSI) guidelines included reporting a urine-specific cefazolin breakpoint for enterobacteriaceae (susceptible ≤16 mcg/mL). Read More

    Patients with community-acquired bacteremia of unknown origin: clinical characteristics and usefulness of microbiological results for therapeutic issues: a single-center cohort study.
    Ann Clin Microbiol Antimicrob 2017 May 19;16(1):40. Epub 2017 May 19.
    Infectious Diseases Department, Hôpital Archet 1, Nice Academic Hospital, Infectiologie 151 Route de St Antoine de Ginestière, 06200, Nice, France.
    Bacteremia of unknown origin (BUO) are associated with increased mortality compared to those with identified sources. Microbiological data of those patients could help to characterize an appropriate empirical antibiotic treatment before bloodcultures results are available during sepsis of unknown origin. Based on the dashboard of our ward that prospectively records several parameters from each hospitalization, we report 101 community-acquired BUO selected among 1989 bacteremic patients from July 2005 to April 2016, BUO being defined by the absence of clinical and paraclinical infectious focus and no other microbiological samples retrieving the bacteria isolated from blood cultures. Read More

    A pre-therapeutic coating for medical devices that prevents the attachment of Candida albicans.
    Ann Clin Microbiol Antimicrob 2017 May 19;16(1):41. Epub 2017 May 19.
    Life Science and Bioengineering Center, Worcester Polytechnic Institute, 60 Prescott Street, Worcester, MA, 01609, USA.
    Background: Hospital acquired fungal infections are defined as "never events"-medical errors that should never have happened. Systemic Candida albicans infections results in 30-50% mortality rates. Typically, adhesion to abiotic medical devices and implants initiates such infections. Read More

    Enzyme-mediated formulation of stable elliptical silver nanoparticles tested against clinical pathogens and MDR bacteria and development of antimicrobial surgical thread.
    Ann Clin Microbiol Antimicrob 2017 May 16;16(1):39. Epub 2017 May 16.
    Department of Biosciences (UGC-SAP-DRS-II), Veer Narmad South Gujarat University, Surat, Gujarat, 395007, India.
    Background: Silver nanoparticles (AgNPs) are believed to be emerging tool against various infectious diseases including multi-drug resistant (MDR) bacteria. In the present study, in vitro synthesis of AgNPs was optimized using 1:50 ratio of macerozyme (25 μg/μl) and 1 mM AgNO3 incubated at 80 °C for 8 h. AgNPs were characterized by UV-Visible spectroscopy, dynamic light scattering (DLS), scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy (TEM) and X-ray diffraction (XRD). Read More

    Determinants of felt demand for dengue vaccines in the North Caribbean region of Colombia.
    Ann Clin Microbiol Antimicrob 2017 May 15;16(1):38. Epub 2017 May 15.
    Department of Epidemiology, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715, São Paulo, SP, CEP-01246-904, Brazil.
    Background: The increasing burden associated with dengue in Latin America makes it essential to understand the community's interest in acquiring vaccines, as an input to plan its introduction in endemic regions. The objective of this study is to learn the felt demand for dengue vaccines by estimating the willingness to pay and its associated factors in endemic communities of the North Caribbean region of Colombia.

    Methods: A population survey was administered from October to December 2015, including 1037 families in 11 municipalities in Colombia. Read More

    Genome sequence of Shigella flexneri strain SP1, a diarrheal isolate that encodes an extended-spectrum β-lactamase (ESBL).
    Ann Clin Microbiol Antimicrob 2017 May 12;16(1):37. Epub 2017 May 12.
    Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
    Background: Shigellosis is the most common cause of gastrointestinal infections in developing countries. In China, the species most frequently responsible for shigellosis is Shigella flexneri. S. Read More

    Vitamin D deficiency among smear positive pulmonary tuberculosis patients and their tuberculosis negative household contacts in Northwest Ethiopia: a case-control study.
    Ann Clin Microbiol Antimicrob 2017 May 11;16(1):36. Epub 2017 May 11.
    Management Sciences for Health, Health Programs Group, Arlington, VA, USA.
    Background: Vitamin D is a fat-soluble vitamin that increases the immunity against tuberculosis (TB), decreases the re-activation of latent TB and reduces the severity of active TB disease. Epidemiological studies on the prevalence of vitamin D deficiency, and its association with TB showed inconsistent results in different countries. This study was aimed to determine the prevalence of vitamin D deficiency and its association with TB in Northwest Ethiopia. Read More

    Antimicrobial resistance and virulence characterization of Staphylococcus aureus and coagulase-negative staphylococci from imported beef meat.
    Ann Clin Microbiol Antimicrob 2017 May 10;16(1):35. Epub 2017 May 10.
    Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
    Background: The objectives of this study were to characterize the diversity and magnitude of antimicrobial resistance among Staphylococcus species recovered from imported beef meat sold in the Egyptian market and the potential mechanisms underlying the antimicrobial resistance phenotypes including harboring of resistance genes (mecA, cfr, gyrA, gyrB, and grlA) and biofilm formation.

    Results: The resistance gene mecA was detected in 50% of methicillin-resistant non-Staphylococcus aureus isolates (4/8). Interestingly, our results showed that: (i) resistance genes mecA, gyrA, gyrB, grlA, and cfr were absent in Staphylococcus hominis and Staphylococcus hemolyticus isolates, although S. Read More

    The emergence of a novel sequence type of MDR Acinetobacter baumannii from the intensive care unit of an Egyptian tertiary care hospital.
    Ann Clin Microbiol Antimicrob 2017 May 10;16(1):34. Epub 2017 May 10.
    Department of Microbiology, Faculty of Science, Zagazig University, Zagazig, Egypt.
    Background And Aim Of Work: Acinetobacter baumannii is known for nosocomial outbreaks worldwide. In this study, we aimed to investigate the antibiotic susceptibility patterns and the clonal relationship of A. baumannii isolates from the intensive care unit (ICU) of an Egyptian hospital. Read More

    Detection of a CTX-M group 2 beta-lactamase gene in a Klebsiella pneumoniae isolate from a tertiary care hospital, Trinidad and Tobago.
    Ann Clin Microbiol Antimicrob 2017 May 8;16(1):33. Epub 2017 May 8.
    Department of Para-Clinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
    Background: Identification of the prevalence and spread of ESBL-mediated antibiotic resistance is essential especially in the hospital setting. It is for this reason, more and more studies are highlighting the importance of complementing phenotypic ESBL-detection techniques with molecular techniques in order to understand the basis and extent of this form of resistance among clinically evolved bacterial populations, especially those belonging to the Enterobacteriaceae family. However, in Trinidad and Tobago and other Caribbean countries, very little is known regarding ESBL detection rates and/or the prevalence of genes conferring ESBL resistance. Read More

    Molecular characteristic of mcr-1 producing Escherichia coli in a Chinese university hospital.
    Ann Clin Microbiol Antimicrob 2017 Apr 19;16(1):32. Epub 2017 Apr 19.
    Department of Clinical Laboratory, Fujian Medical University Union Hospital, 29# Xinquan Road, Fuzhou, 350001, Fujian, China.
    Background: Colistin has been considered as a last-line treatment option in severe infections caused by multidrug-resistant (MDR) gram-negative pathogens. However, the emergence of the mobile colistin resistance gene (mcr-1) has challenged this viewpoint. The aim of this study is to explore the prevalence of mcr-1 in Escherichia coli (E. Read More

    Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature.
    Ann Clin Microbiol Antimicrob 2017 Apr 14;16(1):31. Epub 2017 Apr 14.
    MTA-SZTE "Lendület" Fungal Pathogenicity Mechanisms Research Group, Hungarian Academy of Sciences, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary.
    Background: Scedosporium apiospermum is an emerging opportunistic filamentous fungus, which is notorious for its high levels of antifungal-resistance. It is able to cause localized cutaneous or subcutaneous infections in both immunocompromised and immunocompetent persons, pulmonary infections in patients with predisposing pulmonary diseases and invasive mycoses in immunocompromised patients. Subcutaneous infections caused by this fungus frequently show chronic mycetomatous manifestation. Read More

    Antibiotic resistant airborne bacteria and their multidrug resistance pattern at University teaching referral Hospital in South Ethiopia.
    Ann Clin Microbiol Antimicrob 2017 Apr 12;16(1):29. Epub 2017 Apr 12.
    School of Medicine, College of Health Sciences, Wolaita Sodo University, PO Box: 138, Wolaita Sodo, Ethiopia.
    Background: Hospitals provide a reservoir of microorganisms, many of which are multi-resistant to antibiotics. Emergence of multi-drug resistant strains in a hospital environment, particularly in developing countries is an increasing problem to infection treatment. This study aims at assessing antibiotic resistant airborne bacterial isolates. Read More

    Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study.
    Ann Clin Microbiol Antimicrob 2017 Apr 11;16(1):27. Epub 2017 Apr 11.
    Department of Infectious Diseases, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
    Background: Daptomycin has been reported to cause artificial prolongation of prothrombin time (PT) by interacting with some test reagents of PT. This prolongation was particularly prominent with high concentrations of daptomycin in vitro. However, whether this prolongation is important in clinical settings and the optimal timing to assess PT remain unclear. Read More

    Factors associated with Staphylococcus aureus nasal carriage and molecular characteristics among the general population at a Medical College Campus in Guangzhou, South China.
    Ann Clin Microbiol Antimicrob 2017 Apr 11;16(1):28. Epub 2017 Apr 11.
    Department of Laboratory, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
    Background: The nasal cavity is the main colonization site of Staphylococcus aureus (S. aureus) in human body. Nasal carriage may be a strong risk factor for some serious infection. Read More

    Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone.
    Ann Clin Microbiol Antimicrob 2017 Apr 11;16(1):26. Epub 2017 Apr 11.
    Department of Medicine, Division of Infectious Diseases, Stony Brook University, Stony Brook, USA.
    Background: Babesiosis is a potentially life-threatening, tick-borne infection endemic in New York. The purpose of this study was to review recent trends in babesiosis management and outcomes focusing on patients, who were treated with combination of azithromycin and atovaquone.

    Methods: A retrospective chart review of patients seen at Stony Brook University Hospital between 2008 and 2014 with peripheral blood smears positive for Babesia was performed. Read More

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